Kazuhito Naka

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. doi request reprint TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
    Kazuhito Naka
    Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920 0934, Japan
    Nature 463:676-80. 2010
  2. doi request reprint Nucleostemin in injury-induced liver regeneration
    Haruhiko Shugo
    Division of Molecular Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Stem Cells Dev 21:3044-54. 2012
  3. pmc Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin
    Akira Tamase
    Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920 0934, Japan
    Proc Natl Acad Sci U S A 106:17163-8. 2009
  4. doi request reprint NKX2.2 suppresses self-renewal of glioma-initiating cells
    Teruyuki Muraguchi
    Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
    Cancer Res 71:1135-45. 2011
  5. doi request reprint Abundant nucleostemin expression supports the undifferentiated properties of germ cell tumors
    Noriyuki Uema
    Division of Molecular Genetics, Cancer and Stem Cell Program, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Am J Pathol 183:592-603. 2013
  6. pmc mTORC1 is essential for leukemia propagation but not stem cell self-renewal
    Takayuki Hoshii
    Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    J Clin Invest 122:2114-29. 2012
  7. doi request reprint Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity
    Masako Ohmura
    Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
    Stem Cells 26:3237-46. 2008
  8. doi request reprint Molecular pathology of tumor-initiating cells: lessons from Philadelphia chromosome-positive leukemia
    Kazuhito Naka
    Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Pathol Int 61:501-8. 2011
  9. pmc Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells
    Keisuke Oguma
    Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    EMBO J 27:1671-81. 2008
  10. doi request reprint Maintenance of genomic integrity in hematopoietic stem cells
    Kazuhito Naka
    Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kakuma machi, Kanazawa, Ishikawa, 920 1192, Japan
    Int J Hematol 93:434-9. 2011

Collaborators

Detail Information

Publications15

  1. doi request reprint TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
    Kazuhito Naka
    Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920 0934, Japan
    Nature 463:676-80. 2010
    ..Our results demonstrate a critical role for the TGF-beta-FOXO pathway in the maintenance of LICs, and strengthen our understanding of the mechanisms that specifically maintain CML LICs in vivo...
  2. doi request reprint Nucleostemin in injury-induced liver regeneration
    Haruhiko Shugo
    Division of Molecular Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Stem Cells Dev 21:3044-54. 2012
    ..These data strongly suggest that NS plays a critical role in regeneration of both hepatic precursor cells and hepatocytes in response to liver injury...
  3. pmc Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin
    Akira Tamase
    Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920 0934, Japan
    Proc Natl Acad Sci U S A 106:17163-8. 2009
    ..Thus, the NS-GFP system provides a powerful tool to elucidate stem cell biology in normal and malignant tissues...
  4. doi request reprint NKX2.2 suppresses self-renewal of glioma-initiating cells
    Teruyuki Muraguchi
    Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
    Cancer Res 71:1135-45. 2011
    ..Thus, our mouse models offer pathobiologically significant advantages to investigate the nature of brain tumors, with improved opportunities to develop novel mechanism-based therapeutic approaches...
  5. doi request reprint Abundant nucleostemin expression supports the undifferentiated properties of germ cell tumors
    Noriyuki Uema
    Division of Molecular Genetics, Cancer and Stem Cell Program, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Am J Pathol 183:592-603. 2013
    ..These data indicate that abundant expression of NS supports the undifferentiated properties of germ cell tumors. ..
  6. pmc mTORC1 is essential for leukemia propagation but not stem cell self-renewal
    Takayuki Hoshii
    Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    J Clin Invest 122:2114-29. 2012
    ..Thus, AML cells lacking mTORC1 activity can self-renew as AML stem cells. Our findings provide mechanistic insight into how residual tumor cells circumvent anticancer therapies and drive tumor recurrence...
  7. doi request reprint Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity
    Masako Ohmura
    Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
    Stem Cells 26:3237-46. 2008
    ..We conclude that NS is a marker of undifferentiated status in the germ cell lineage during prepubertal spermatogenesis...
  8. doi request reprint Molecular pathology of tumor-initiating cells: lessons from Philadelphia chromosome-positive leukemia
    Kazuhito Naka
    Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Pathol Int 61:501-8. 2011
    ..Our expanding knowledge of the biology of TIC contributes to the progress of cancer research, and may open the door to new concepts in cancer therapy...
  9. pmc Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells
    Keisuke Oguma
    Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    EMBO J 27:1671-81. 2008
    ..These results suggest that macrophage-derived TNF-alpha promotes Wnt/beta-catenin signalling through inhibition of GSK3beta, which may contribute to tumour development in the gastric mucosa...
  10. doi request reprint Maintenance of genomic integrity in hematopoietic stem cells
    Kazuhito Naka
    Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kakuma machi, Kanazawa, Ishikawa, 920 1192, Japan
    Int J Hematol 93:434-9. 2011
    ..Dissection of HSC-specific mechanisms for the maintenance of genomic integrity may provide valuable insights into the biology of both HSCs and leukemia stem cells...
  11. doi request reprint Novel therapeutic approach to eradicate tyrosine kinase inhibitor resistant chronic myeloid leukemia stem cells
    Kazuhito Naka
    Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Sci 101:1577-81. 2010
    ..Thus, development of methods that sensitize CML stem cells to TKI therapy may lead to novel therapies to treat CML patients...
  12. doi request reprint Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells
    Kazuhito Naka
    Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
    Antioxid Redox Signal 10:1883-94. 2008
    ....
  13. pmc MIP-1α/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia
    Tomohisa Baba
    Division of Molecular Bioregulation, 2 Exploratory Project on Cancer Stem Cells, and 3 Division of Molecular Genetics, Cancer Research Institute, Kanazawa University, Kanazawa 920 1192, Ishikawa, Japan
    J Exp Med 210:2661-73. 2013
    ..Finally, normal hematopoietic stem/progenitor cells can directly impede the maintenance of LICs in BM in the absence of CCL3 signal. ..
  14. doi request reprint B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells
    Guihua Jin
    Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    J Allergy Clin Immunol 131:1674-82. 2013
    ..B-cell linker protein (BLNK) is an essential component of the B-cell antigen receptor signaling pathway and is required for optimal B-cell development...
  15. ncbi request reprint Regulation of the self-renewal ability of tissue stem cells by tumor-related genes
    Kazuhito Naka
    Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, 920 0934, Japan
    Cancer Biomark 3:193-201. 2007
    ..Further investigation of stem cell regulation by tumor-related genes may pave the way for successful stem cell-based approaches to regenerative medicine and cancer therapy...