N Mukaida

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi Interleukin-8: an expanding universe beyond neutrophil chemotaxis and activation
    N Mukaida
    Division of Molecular Bioregulation, Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Int J Hematol 72:391-8. 2000
  2. ncbi Mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cells
    Hiromitsu Teruya
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    BMC Microbiol 7:102. 2007
  3. ncbi Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells
    Reika Takamatsu
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    BMC Microbiol 10:1. 2010
  4. ncbi Roles of Pim-3, a novel survival kinase, in tumorigenesis
    Naofumi Mukaida
    Division of Molecular Bioregulation, Cancer Microenvironment Research Program, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Sci 102:1437-42. 2011
  5. ncbi Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases
    Naofumi Mukaida
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Japan
    Am J Physiol Lung Cell Mol Physiol 284:L566-77. 2003
  6. ncbi Inhibition of neutrophil-mediated acute inflammation injury by an antibody against interleukin-8 (IL-8)
    N Mukaida
    Department of Molecular Pharmacology, Cancer Research Institute, Kanazawa University, Ishikawa, Japan
    Inflamm Res 47:S151-7. 1998
  7. ncbi Chemokines in tumor development and progression
    Naofumi Mukaida
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Exp Cell Res 318:95-102. 2012
  8. ncbi Enhanced anti-tumor effects of herpes simplex virus thymidine kinase/ganciclovir system by codelivering monocyte chemoattractant protein-1 in hepatocellular carcinoma
    Y Sakai
    First Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
    Cancer Gene Ther 8:695-704. 2001
  9. ncbi MIP-1alpha and MCP-1 contribute to crescents and interstitial lesions in human crescentic glomerulonephritis
    T Wada
    First Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Kidney Int 56:995-1003. 1999
  10. ncbi A new anti-inflammatory compound, FR167653, ameliorates crescentic glomerulonephritis in Wistar-Kyoto rats
    T Wada
    First Department of Internal Medicine and Division of Blood Purification, School of Medicine, Kanazawa University, Japan
    J Am Soc Nephrol 11:1534-41. 2000

Collaborators

Detail Information

Publications95

  1. ncbi Interleukin-8: an expanding universe beyond neutrophil chemotaxis and activation
    N Mukaida
    Division of Molecular Bioregulation, Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Int J Hematol 72:391-8. 2000
    ..Potential involvement of IL-8 in viral infections and tumor progression is also discussed...
  2. ncbi Mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cells
    Hiromitsu Teruya
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    BMC Microbiol 7:102. 2007
    ..We investigated the effect of L. pneumophila on the expression of interleukin-8 (IL-8) in human A549 alveolar and NCI-H292 tracheal epithelial cell lines...
  3. ncbi Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells
    Reika Takamatsu
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    BMC Microbiol 10:1. 2010
    ..pneumophila to infect and stimulate the production of interleukin-8 (IL-8) in T cells. The objective of this study was to assess whether L. pneumophila interferes with the immune system by interacting and infecting T cells...
  4. ncbi Roles of Pim-3, a novel survival kinase, in tumorigenesis
    Naofumi Mukaida
    Division of Molecular Bioregulation, Cancer Microenvironment Research Program, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Sci 102:1437-42. 2011
    ..Thus, Pim-3 kinase may be a candidate molecule for the development of molecular targeting drugs against cancer...
  5. ncbi Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases
    Naofumi Mukaida
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Japan
    Am J Physiol Lung Cell Mol Physiol 284:L566-77. 2003
    ..Here, an overview of its protein structure, mechanisms of production, and receptor system will be discussed as well as the pathophysiological roles of IL-8/CXCL8 in various types of lung pathologies...
  6. ncbi Inhibition of neutrophil-mediated acute inflammation injury by an antibody against interleukin-8 (IL-8)
    N Mukaida
    Department of Molecular Pharmacology, Cancer Research Institute, Kanazawa University, Ishikawa, Japan
    Inflamm Res 47:S151-7. 1998
    ..These results raise the possibility that IL-8 is a novel target for therapeutic intervention in neutrophil-mediated acute inflammation...
  7. ncbi Chemokines in tumor development and progression
    Naofumi Mukaida
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Exp Cell Res 318:95-102. 2012
    ..The wide range of activities of chemokines in tumorigenesis highlights their roles in tumor development and progression...
  8. ncbi Enhanced anti-tumor effects of herpes simplex virus thymidine kinase/ganciclovir system by codelivering monocyte chemoattractant protein-1 in hepatocellular carcinoma
    Y Sakai
    First Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
    Cancer Gene Ther 8:695-704. 2001
    ....
  9. ncbi MIP-1alpha and MCP-1 contribute to crescents and interstitial lesions in human crescentic glomerulonephritis
    T Wada
    First Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Kidney Int 56:995-1003. 1999
    ....
  10. ncbi A new anti-inflammatory compound, FR167653, ameliorates crescentic glomerulonephritis in Wistar-Kyoto rats
    T Wada
    First Department of Internal Medicine and Division of Blood Purification, School of Medicine, Kanazawa University, Japan
    J Am Soc Nephrol 11:1534-41. 2000
    ....
  11. ncbi Distinct expression of CCR1 and CCR5 in glomerular and interstitial lesions of human glomerular diseases
    K Furuichi
    First Department of Internal Medicine and Division of Blood Purification, School of Medicine, Kanazawa National Hospital, Kanazawa, Japan
    Am J Nephrol 20:291-9. 2000
    ..CCR1 may be involved in interstitial lesions in resolving phase after glucocorticoid therapy...
  12. ncbi Cloning of a cDNA encoding a mouse homolog of the interleukin-8 receptor
    A Harada
    Department of Pharmacology, Kanazawa University, Japan
    Gene 142:297-300. 1994
    ....
  13. ncbi Alleviation of lipopolysaccharide-induced acute liver injury in Propionibacterium acnes-primed IFN-gamma-deficient mice by a concomitant reduction of TNF-alpha, IL-12, and IL-18 production
    H Tsuji
    First Department of Internal Medicine, School of Medicine, Kanazawa University, Ishikawa, Japan
    J Immunol 162:1049-55. 1999
    ..Thus, endogenously produced IFN-gamma is involved in the pathogenesis of this liver injury model by regulating Mphi infiltration and granuloma formation in the priming phase as well as cytokine production in the eliciting phase...
  14. ncbi Membrane-bound form of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma
    Y Marukawa
    Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Cancer Gene Ther 19:312-9. 2012
    ....
  15. ncbi Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization
    Y Nakamoto
    Cancer Research Institute, Kanazawa University, Japan
    Clin Exp Immunol 163:165-77. 2011
    ..Collectively, this study suggests that a DC-based, active immunotherapeutic strategy in combination with locoregional treatments exerts beneficial anti-tumour effects against liver cancer...
  16. ncbi Attenuated liver fibrosis and depressed serum albumin levels in carbon tetrachloride-treated IL-6-deficient mice
    M Natsume
    Department of Molecular Oncology, Cancer Research Institute, School of Medicine, Kanazawa University, Japan
    J Leukoc Biol 66:601-8. 1999
    ..Thus, IL-6 may be vitally involved in fibrotic changes and maintenance of serum albumin levels, partly by modulating intrahepatic expression of these cytokines...
  17. ncbi Urinary levels of chemokines (MCAF/MCP-1, IL-8) reflect distinct disease activities and phases of human IgA nephropathy
    H Yokoyama
    First Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    J Leukoc Biol 63:493-9. 1998
    ....
  18. ncbi Up-regulation of monocyte chemoattractant protein-1 in tubulointerstitial lesions of human diabetic nephropathy
    T Wada
    First Department of Internal Medicine and Division of Blood Purification, School of Medicine, and Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Kidney Int 58:1492-9. 2000
    ..However, the expression of MCP-1 in diabetic nephropathy remains to be investigated...
  19. ncbi Enhanced airway inflammation and decreased subepithelial fibrosis in interleukin 6-deficient mice following chronic exposure to aerosolized antigen
    Z Qiu
    Respiratory Medicine, Cellular Transplantation Biology, Kanazawa Graduate University School of Medicine, Kanazawa, Japan
    Clin Exp Allergy 34:1321-8. 2004
    ..CONCLUSION: These results suggest that IL-6 has dual roles in the chronic phase of asthma: down-regulation of inflammatory cell infiltration and enhancement of airway remodelling...
  20. ncbi Tumor necrosis factor receptor p55 is essential for intrahepatic granuloma formation and hepatocellular apoptosis in a murine model of bacterium-induced fulminant hepatitis
    H Tsuji
    Department of Pharmacology, Cancer Research Institute, Kanazawa University, Takara machi, Japan
    Infect Immun 65:1892-8. 1997
    ..These results suggest that TNFRp55 but not Fas was involved in P. acnes-induced granuloma formation as well as subsequent LPS-induced liver injury and that TNFRp55 and Fas independently induced apoptosis of hepatocytes in vivo...
  21. ncbi Monocyte chemoattractant protein-1 gene delivery enhances antitumor effects of herpes simplex virus thymidine kinase/ganciclovir system in a model of colon cancer
    T Kagaya
    Department of Gastroenterology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Cancer Gene Ther 13:357-66. 2006
    ..These results suggest an immunomodulatory effect of MCP-1 in the context of suicide gene therapy of colon cancer via orchestration of innate and acquired immune responses...
  22. ncbi Potential involvement of monocyte chemoattractant protein (MCP)-1/CCL2 in IL-4-mediated tumor immunity through inducing dendritic cell migration into the draining lymph nodes
    Hui Wang
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan
    Int Immunopharmacol 3:627-42. 2003
    ..Thus, locally produced MCP-1/CCL2 may be responsible for IL-4-mediated tumor rejection presumably based on the induction of dendritic cell migration into the draining lymph nodes...
  23. ncbi Blockade of CCR2 ameliorates progressive fibrosis in kidney
    Kiyoki Kitagawa
    Department of Gastroenterology and Nephrology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Am J Pathol 165:237-46. 2004
    ..These findings suggest that the therapeutic strategy of blocking CCR2 may prove beneficial for progressive fibrosis via the decrease in infiltration and activation of macrophages in the diseased kidneys...
  24. ncbi Essential involvement of IFN-gamma in Clostridium difficile toxin A-induced enteritis
    Yuko Ishida
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    J Immunol 172:3018-25. 2004
    ..These observations indicate that IFN-gamma is the crucial mediator of toxin A-induced acute enteritis and suggest that IFN-gamma is an important molecular target for the control of C. difficile-associated pseudomembranous colitis...
  25. ncbi The essential involvement of cross-talk between IFN-gamma and TGF-beta in the skin wound-healing process
    Yuko Ishida
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    J Immunol 172:1848-55. 2004
    ..These results demonstrate that there is crosstalk between the IFN-gamma/Stat1 and TGF-beta1/Smad signaling pathways in the wound healing process...
  26. ncbi Interleukin-8 (IL-8) and monocyte chemotactic and activating factor (MCAF/MCP-1), chemokines essentially involved in inflammatory and immune reactions
    N Mukaida
    Department of Molecular Pharmacology, Cancer Research Institute, Kanazawa University, Japan
    Cytokine Growth Factor Rev 9:9-23. 1998
    ..We discuss further potential roles of these chemokines in T-lymphocyte-mediated immune responses...
  27. ncbi Combined therapy of transcatheter hepatic arterial embolization with intratumoral dendritic cell infusion for hepatocellular carcinoma: clinical safety
    Y Nakamoto
    Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa, Japan
    Clin Exp Immunol 147:296-305. 2007
    ..Furthermore, the antigen-non-specific, immature DC infusion may induce immune responses to unprimed tumour antigens, providing a plausible strategy to enhance tumour immunity...
  28. ncbi The pathogenic roles of tumor necrosis factor receptor p55 in acetaminophen-induced liver injury in mice
    Yuko Ishida
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Ishikawa, Japan
    J Leukoc Biol 75:59-67. 2004
    ..Collectively, the TNF-alpha-TNF-Rp55 axis has pathogenic roles in APAP-induced liver failure...
  29. ncbi CCR2 signaling contributes to ischemia-reperfusion injury in kidney
    Kengo Furuichi
    Department of Gastroenterology and Nephrology and Division of Blood Purification, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    J Am Soc Nephrol 14:2503-15. 2003
    ....
  30. ncbi Gene therapy via blockade of monocyte chemoattractant protein-1 for renal fibrosis
    Takashi Wada
    Department of Gastroenterology and Nephrology, Graduate School of Medical Science and Division of Blood Purification, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Am Soc Nephrol 15:940-8. 2004
    ..Moreover, these findings imply that gene therapy against MCP-1/CCR2 signaling via the mutant gene transferred strategy may serve a beneficial therapeutic application for renal fibrosis...
  31. ncbi Administration of FR167653, a new anti-inflammatory compound, prevents renal ischaemia/reperfusion injury in mice
    Kengo Furuichi
    Department of Gastroenterology and Nephrology, and Division of Blood Purification, Cancer Research Institute, Kanazawa University, Tokyo, Japan
    Nephrol Dial Transplant 17:399-407. 2002
    ..We explored the effect of FR167653, a specific inhibitor of p38 MAPK, on renal ischaemia/reperfusion injury in mice...
  32. ncbi Pivotal roles of interleukin-6 in transmural inflammation in murine T cell transfer colitis
    Kazuya Kitamura
    Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Takara machi 13 1, Kanazawa 920 8641, Japan
    J Leukoc Biol 76:1111-7. 2004
    ..Thus, IL-6 might be a promising target for treating transmural inflammation in Crohn's disease, which can lead to severe complications such as strictures, fissures, and fistulas...
  33. ncbi Implication of "Down syndrome cell adhesion molecule" in the hippocampal neurogenesis of ischemic monkeys
    Tetsumori Yamashima
    Department of Restorative Neurosurgery, Kanazawa University, Graduate School of Medical Science, Kanazawa, Japan
    Hippocampus 16:924-35. 2006
    ..Young astrocytes were in intimate contact with newly generated neurons in the subgranular zone. These data suggest implication of DSCAM in the adult neurogenesis of primate hippocampus upregulated after ischemia...
  34. ncbi Gene therapy expressing amino-terminal truncated monocyte chemoattractant protein-1 prevents renal ischemia-reperfusion injury
    Kengo Furuichi
    Department of Gastroenterology and Nephrology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    J Am Soc Nephrol 14:1066-71. 2003
    ..These results provide evidence that gene therapy by 7ND is potentially a powerful therapeutic approach to inhibit MCP-1/CCR2 signaling, resulting in rescue from renal ischemia-reperfusion injury...
  35. ncbi Pathogenic roles of tumor necrosis factor receptor p55-mediated signals in dimethylnitrosamine-induced murine liver fibrosis
    Kazuya Kitamura
    Department of Gastroenterology, Graduate School of Medicinal Sciences, Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Lab Invest 82:571-83. 2002
    ..Collectively, TNFRp55-mediated signals may regulate activation of Kupffer cells and HSCs and eventually enhance fibrotic process...
  36. ncbi Fas ligand induces cell-autonomous NF-kappaB activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha
    Ryu Imamura
    Center for the Development of Molecular Target Drugs, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 0934, Japan
    J Biol Chem 279:46415-23. 2004
    ..In addition, we found that mouse FADD had a dominant-negative effect on the FasL-induced NF-kappaB activation in HEK293 cells, which may indicate a species difference between human and mouse in the FasL-induced NF-kappaB activation...
  37. ncbi Accelerated wound healing in tumor necrosis factor receptor p55-deficient mice with reduced leukocyte infiltration
    Ryoichi Mori
    Division of Environmental Science, Forensic and Social Environmental Medicine, Graduate School of Medical Science, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    FASEB J 16:963-74. 2002
    ..These observations suggest that TNF-Rp55-mediated signals have some role in promoting leukocyte infiltration at the wound site and negatively affect wound healing, probably by reducing angiogenesis and collagen accumulation...
  38. ncbi The frequency of type 2 CD8+ T cells is increased in peripheral blood from patients with psoriasis vulgaris
    Makoto Inaoki
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Clin Immunol 23:269-78. 2003
    ..Our findings suggest an increase in Tc2 cell number in blood from psoriatic patients, and the association of Tc2 cells with inflammation in psoriasis...
  39. ncbi A pivotal involvement of IFN-gamma in the pathogenesis of acetaminophen-induced acute liver injury
    Yuko Ishida
    Division of Environmental Sciences, Forensic and Social Environmental Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan
    FASEB J 16:1227-36. 2002
    ..Moreover, immunoneutralization of IFN-gamma may be therapeutically effective for developing APAP-induced liver injury...
  40. ncbi Expression of both types of human interleukin-8 receptors on mature neutrophils, monocytes, and natural killer cells
    H Morohashi
    Department of Pharmacology, Cancer Research Institute, Kanazawa, Japan
    J Leukoc Biol 57:180-7. 1995
    ..These results suggest that both types of human IL-8 receptors were coordinately and selectively expressed in mature granulocytes, monocytes, and CD16+ NK cells...
  41. ncbi Molecular analysis of the cytokine network involved in cachexia in colon 26 adenocarcinoma-bearing mice
    K Yasumoto
    Department of Pharmacology, Hospital Pharmacy, Kanazawa University, Japan
    Cancer Res 55:921-7. 1995
    ..Collectively, additional factor(s) besides IL-1Ra and IL-1 beta may control IL-6 and some other cachexigenic factor production, thereby causing cachexia in this model...
  42. ncbi Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury
    Yuko Ishida
    Division of Molecular Bioregulation, Kanazawa University Cancer Research Institute, Kanazawa, Japan
    Eur J Immunol 36:1028-38. 2006
    ..Thus, CXCR2 may regulate the infiltration of both iNOS-expressing neutrophils and HO-1-expressing macrophages, and the balance between these two molecules may determine the outcome of APAP-induced liver injury...
  43. ncbi Potential interaction between CCR1 and its ligand, CCL3, induced by endogenously produced interleukin-1 in human hepatomas
    Peirong Lu
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Am J Pathol 162:1249-58. 2003
    ..Thus, IL-1 may enhance the local production of CCL3, which may interact with CCR1 expressed on hepatoma cells, in an autocrine and/or paracrine manner...
  44. ncbi Essential roles of tumor necrosis factor receptor p55 in liver metastasis of intrasplenic administration of colon 26 cells
    Hidekazu Kitakata
    Division of Molecular Bioregulation, Kanazawa University, Kanazawa 920-0934, Japan
    Cancer Res 62:6682-7. 2002
    ..Collectively, these observations suggest that TNF-Rp55-mediated signals can up-regulate both VCAM-1 expression in the liver and subsequent liver metastasis after intrasplenic tumor injection...
  45. ncbi Involvement of p38 mitogen-activated protein kinase followed by chemokine expression in crescentic glomerulonephritis
    T Wada
    Department of Internal Medicine and Division of Blood Purificationd, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Am J Kidney Dis 38:1169-77. 2001
    ..This study provides evidence that regulation of p38 MAPK is a novel appealing therapeutic target for crescentic glomerulonephritis...
  46. ncbi Abnormal expression of intracellular cytokines and chemokine receptors in peripheral blood T lymphocytes from patients with systemic sclerosis
    H Fujii
    Department of Dermatology, Cancer Research Institute, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Clin Exp Immunol 130:548-56. 2002
    ..Tc1 cells may be associated with pulmonary vascular damage in SSc...
  47. ncbi Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells
    Ying Yi Li
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Sci 100:396-404. 2009
    ..These observations would indicate that the transcription factor Ets-1 can induce aberrant Pim-3 expression and subsequently prevent apoptosis in human pancreatic cancer cells...
  48. ncbi Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression
    Xiaoqin Yang
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Int J Cancer 118:1869-76. 2006
    ..These observations suggest the contribution of the CCR1-CCL3 axis to HCC progression...
  49. ncbi Tumor cell apoptosis induces tumor-specific immunity in a CC chemokine receptor 1- and 5-dependent manner in mice
    Noriho Iida
    Cancer Research Institute, Kanazawa University, Kanazawa 920 0934, Japan
    J Leukoc Biol 84:1001-10. 2008
    ....
  50. ncbi Crucial involvement of the CX3CR1-CX3CL1 axis in dextran sulfate sodium-mediated acute colitis in mice
    Feodora I Kostadinova
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    J Leukoc Biol 88:133-43. 2010
    ..These observations would indicate that the CX3CL1-CX3CR1 axis can regulate the expression of iNOS, a crucial mediator of DSS-induced colitis. Thus, targeting the CX3CL1-CX3CR1 axis may be effective for the treatment of IBDs such as UC...
  51. ncbi Spontaneous regression of lung metastasis in the absence of tumor necrosis factor receptor p55
    Yoshiharu Tomita
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Int J Cancer 112:927-33. 2004
    ..Thus, TNF-Rp55-mediated signals can maintain tumor neovascularization at least partly by inducing HGF expression, and eventually support lung metastasis process...
  52. ncbi p38 MAPK phosphorylation and NF-kappa B activation in human crescentic glomerulonephritis
    Norihiko Sakai
    Department of Gastroenterology and Nephrology, and Division of Blood Purification, Graduate School of Medicine, Kanazawa University, Japan
    Nephrol Dial Transplant 17:998-1004. 2002
    ..The pathophysiological roles of p38 MAPK and NF-kappa B in human glomerulonephritis, however, remain to be investigated...
  53. ncbi Tumor necrosis factor (TNF) is a physiologic regulator of hematopoietic progenitor cells: increase of early hematopoietic progenitor cells in TNF receptor p55-deficient mice in vivo and potent inhibition of progenitor cell proliferation by TNF alpha in vi
    Y Zhang
    Department of Pharmacology, School of Medicine, Kanazawa University, Japan
    Blood 86:2930-7. 1995
    ..These data suggest that TNF may be an important physiologic regulator of hematopoiesis and that TNF-R55 may be essentially involved in TNF-mediated inhibition of the growth of both primitive stem and more committed progenitor cells...
  54. ncbi Prolonged, NK cell-mediated antitumor effects of suicide gene therapy combined with monocyte chemoattractant protein-1 against hepatocellular carcinoma
    Tomoya Tsuchiyama
    Department of Gastroenterology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    J Immunol 178:574-83. 2007
    ....
  55. ncbi IFN-inducible protein 10 (CXCL10) regulates tubular cell proliferation in renal ischemia-reperfusion injury
    Kengo Furuichi
    Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Nephron Exp Nephrol 109:c29-38. 2008
    ..These data suggest that CXCL10 plays a role in the regulation of tubular cell proliferation following renal ischemia-reperfusion injury...
  56. ncbi Crucial contribution of thymic Sirp alpha+ conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner
    Tomohisa Baba
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
    J Immunol 183:3053-63. 2009
    ..Given their intrathymic cortical localization, CD11c(+)B220(-)CD8alpha(-)Sirpalpha(+) cDCs can have a unique role in the development of central tolerance against circulating peripheral Ags, at least partially in a CCR2-dependent manner...
  57. ncbi Optimal amount of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy against hepatocellular carcinoma by M1 macrophage activation
    Tomoya Tsuchiyama
    Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Cancer Sci 99:2075-82. 2008
    ....
  58. ncbi Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis
    Boryana K Popivanova
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    J Clin Invest 118:560-70. 2008
    ..These observations identify TNF-alpha as a crucial mediator of the initiation and progression of colitis-associated colon carcinogenesis and suggest that targeting TNF-alpha may be useful in treating colon cancer in individuals with UC...
  59. ncbi Enhanced antitumor effects of a bicistronic adenovirus vector expressing both herpes simplex virus thymidine kinase and monocyte chemoattractant protein-1 against hepatocellular carcinoma
    Tomoya Tsuchiyama
    Department of Gastroenterology, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan
    Cancer Gene Ther 10:260-9. 2003
    ....
  60. ncbi Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages and neovascularization
    Xiaoqin Yang
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Int J Cancer 118:335-45. 2006
    ....
  61. ncbi Role of C-C chemokine receptors 1 and 5 and CCL3/macrophage inflammatory protein-1alpha in the cutaneous Arthus reaction: possible attenuation of their inhibitory effects by compensatory chemokine production
    Koichi Yanaba
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Eur J Immunol 34:3553-61. 2004
    ..These results indicate that CCR1, CCR5, and CCL3 cooperatively contribute to the cutaneous Arthus reaction, and also suggest that enhanced expression of CCL3 and CCL5 compensates for the loss of CCR1, CCR5, and CCL3 in the reaction...
  62. ncbi CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process
    Yu Wu
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
    J Immunol 181:6384-93. 2008
    ..Collectively, the CCL3-CCR5 axis appears to regulate intratumoral trafficking of leukocytes and fibroblasts, as well as MMP-9 and HGF expression, and as a consequence to accelerate neovascularization and subsequent metastasis formation...
  63. ncbi hTERT-promoter-based tumor-specific expression of MCP-1 effectively sensitizes cervical cancer cells to a low dose of cisplatin
    Mitsuhiro Nakamura
    Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University, 13-1, Takaramachi, Kanazawa, Ishikawa 920-8641, Japan
    Cancer Gene Ther 11:1-7. 2004
    ..This system may be a novel strategy for chemotherapy combined with immunogene therapy against otherwise intractable cervical cancers...
  64. ncbi [Percentage of T cells bearing receptors for IgG or IgM Fc portion]
    Naofumi Mukaida
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University
    Nippon Rinsho 63:778-80. 2005
  65. ncbi Intrahepatic interleukin-8 production during disease progression of chronic hepatitis C
    Yoshiya Tachibana
    Department of Gastroenterology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8641, Ishikawa, Japan
    Cancer Lett 251:36-42. 2007
    ..The results demonstrate that IL-8 production may be augmented upon the malignant transformation of hepatocytes in chronic hepatitis C...
  66. ncbi Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice
    Boryana Konstantinova Popivanova
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Res 69:7884-92. 2009
    ....
  67. ncbi Antitumor effect after radiofrequency ablation of murine hepatoma is augmented by an active variant of CC Chemokine ligand 3/macrophage inflammatory protein-1alpha
    Noriho Iida
    Disease Control and Homeostasis, Graduate School of Medical Science, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Res 70:6556-65. 2010
    ..Thus, we proved that ECI301 further augments RFA-induced antitumor immune responses in a CCR1-dependent manner...
  68. ncbi Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation
    Junzo Hisatsune
    Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    J Immunol 180:5017-27. 2008
    ..Thus, in U937 cells, VacA directly increases IL-8 production by activation of the p38 MAPK via intracellular Ca(2+) release, leading to activation of the transcription factors, ATF-2, CREB, and NF-kappaB...
  69. ncbi Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced antiangiogenic factor expression
    Peirong Lu
    Clinical Immunology Key Laboratory of Jiangsu Province, First Affiliated Hospital of Suzhou University, Suzhou, China
    J Immunol 180:4283-91. 2008
    ....
  70. ncbi Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice
    Zi Qing Lin
    Faculty of Forensic Medicine, China Criminal Police College, Shenyang, China
    J Leukoc Biol 73:713-21. 2003
    ..These observations suggest that IL-6 has crucial roles in wound healing, probably by regulating leukocyte infiltration, angiogenesis, and collagen accumulation...
  71. ncbi Essential involvement of CX3CR1-mediated signals in the bactericidal host defense during septic peritonitis
    Yuko Ishida
    Department of Forensic Medicine and
    J Immunol 181:4208-18. 2008
    ....
  72. ncbi Essential contribution of CCL3 to alkali-induced corneal neovascularization by regulating vascular endothelial growth factor production by macrophages
    Peirong Lu
    Clinical Immunology Key Laboratory of Jiangsu Province, the First Affilated Hospital of Soochow University, Suzhou, China
    Mol Vis 14:1614-22. 2008
    ..To evaluate the roles of CCL3 and its specific chemokine receptors, CCR1 and CCR5, in alkali-induced corneal neovascularization (CNV)...
  73. ncbi Potential involvement of IL-8 and its receptors in the invasiveness of pancreatic cancer cells
    Yukio Kuwada
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8551, Japan
    Int J Oncol 22:765-71. 2003
    ..These results demonstrate that IL-8 and IL-8 receptors are over-expressed in pancreatic cancer, and suggest that IL-8 regulates MMP-2 activity and plays an important role in the invasiveness of human pancreatic cancer...
  74. ncbi Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells
    Young D Jung
    Chonnam National University Research Institute of Medical Sciences, Hakdong 5, Kwangju, Korea
    Cytokine 18:206-13. 2002
    ..Our data demonstrate that AP-1 and NF-kappaB are essential transcription factors for IL-1beta-induced IL-8 gene expression in hVSMCs. P38 MAPK is involved in inducing IL-8 gene transcription via AP-1 activation in hVSMCs...
  75. ncbi PPARalpha activation abolishes LDL-stimulated IL-8 production via AP-1 deactivation in human aortic smooth muscle cells
    Sungwoo Ryoo
    Genomic Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejeon, Republic of Korea
    Biochem Biophys Res Commun 318:329-34. 2004
    ..These data suggest that AP-1 is likely to be located at the crossroads between LDL signaling and the regulation of IL-8 modulation by PPARalpha...
  76. ncbi Interleukin-1beta stimulates IL-8 expression through MAP kinase and ROS signaling in human gastric carcinoma cells
    Young S Hwang
    Department of Biochemistry, Chonnam University Research Institute of Medical Sciences, Chonnam National University Medical School, 5 Hakdong, Kwangju, 501 190, Korea
    Oncogene 23:6603-11. 2004
    ..The above results suggest that MAPK-AP-1 and ROS-NF-kappaB signaling pathways are involved in the IL-1beta-induced IL-8 expression and that these paracrine signaling pathways induce endothelial cell proliferation...
  77. ncbi IL-1beta induces IL-8 in bronchial cells via NF-kappaB and NF-IL6 transcription factors and can be suppressed by glucocorticoids
    Michael R Edwards
    Department of Respiratory Medicine, St Mary s Hospital, National Heart Lung Institute, Imperial College London, Norfolk Place W2 1PG, London, UK
    Pulm Pharmacol Ther 18:337-45. 2005
    ....
  78. ncbi Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-kappaB activation and a reciprocal suppression of TGF-beta signal pathway
    Yuko Ishida
    Department of Forensic Medicine, Wakayama Medical University, 811 1 Kimidera, Wakayama 641 8509, Japan
    J Immunol 176:5598-606. 2006
    ..Thus, the absence of IL-1ra may suppress TGF-beta-mediated signaling pathway, which is crucial for collagen deposition and vascular endothelial growth factor-mediated neovascularization in wound healing...
  79. ncbi Progressive biliary destruction is independent of a functional tumor necrosis factor-alpha pathway in a rhesus rotavirus-induced murine model of biliary atresia
    Rebecca M Tucker
    Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Viral Immunol 20:34-43. 2007
    ..In summary, although RRV-inoculated BALB/c mice have highly elevated expression of TNF-alpha, this cytokine does not play an obligate role in disease progression...
  80. ncbi Interferon-gamma plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression
    Akihiko Kimura
    Department of Forensic Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Am J Pathol 169:1118-28. 2006
    ..Thus, IFN-gamma can protect against NaAs-induced acute renal injury, probably by maintaining Nrf2-mediated intrarenal MRP1 gene expression...
  81. ncbi MRP-1 expression levels determine strain-specific susceptibility to sodium arsenic-induced renal injury between C57BL/6 and BALB/c mice
    Akihiko Kimura
    Department of Forensic Medicine, Wakayama Medical University, Kimiidera, 641-8509 Wakayama, Japan
    Toxicol Appl Pharmacol 203:53-61. 2005
    ..Thus, MRP-1 is crucially involved in arsenic efflux and eventually prevention of acute renal injury upon acute exposure to NaAs...
  82. ncbi IFN-gamma protects cerulein-induced acute pancreatitis by repressing NF-kappa B activation
    Takahito Hayashi
    Department of Forensic Medicine, Wakayama Medical University, Wakayama, Japan
    J Immunol 178:7385-94. 2007
    ..Thus, IFN-gamma can have anti-inflammatory effects on acute pancreatitis by depressing the proinflammatory consequences of NF-kappaB activation...
  83. ncbi Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration
    Yuko Ishida
    Department of Forensic Medicine, Wakayama Medical University, Wakayama, Japan
    Am J Pathol 170:843-54. 2007
    ....
  84. ncbi Alkali-induced corneal neovascularization is independent of CXCR2-mediated neutrophil infiltration
    Peirong Lu
    Department of Ophthalmology, First Affiliated Hospital of Suzhou University, Suzhou, China
    Cornea 26:199-206. 2007
    ..To study the role of infiltrating neutrophils in the development of experimental corneal neovascularization (CNV)...
  85. ncbi Monocyte chemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment
    Tsuyoshi Kuroda
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences and Health Service Center, Hiroshima University, Japan
    Clin Cancer Res 11:7629-36. 2005
    ..The present study was undertaken to obtain direct evidence that MCP-1 participates in recruitment of macrophages and induction of angiogenesis...
  86. ncbi Augmented expression of tumour necrosis factor-alpha induced by lipopolysaccharide in spleen of human monocyte chemoattractant protein-1 transgenic mouse enhances the lipopolysaccharide sensitivity of the marginal zone macrophages
    Manabu Ato
    Division of Immunobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University Sapporo, Japan
    Immunology 106:554-63. 2002
    ....
  87. ncbi Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas
    Masahiro Ohta
    Department of Medicine and Molecular Science, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Int J Cancer 102:220-4. 2002
    ..These results suggest that interactions between cancer cells and macrophages are important for tumor angiogenesis. MCP-1 may play a role in progression of human esophageal carcinoma through its role in angiogenesis...
  88. ncbi Redistributions of macrophages expressing the macrophage galactose-type C-type lectin (MGL) during antigen-induced chronic granulation tissue formation
    Kayoko Sato
    Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
    Int Immunol 17:559-68. 2005
    ..Results suggest that MGL1/2-positive cells represent a distinct sub-population of macrophages, having unique functions in the generation and maintenance of granulation tissue induced by antigenic stimuli...
  89. ncbi Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas
    Masahiro Ohta
    Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan
    Int J Oncol 22:773-8. 2003
    ..These results suggest that MCP-1 produced by human gastric carcinoma cells plays a role in angiogenesis via macrophage recruitment and activation...
  90. ncbi Role of NF-kappaB and AP-1 on Helicobater pylori-induced IL-8 expression in AGS cells
    Sang Hui Chu
    Department of Pharmacology and Institute of Gastroenterology, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Dig Dis Sci 48:257-65. 2003
    ..Antioxidants such as NAC might be useful anti-inflammatory agents by inhibiting activation of transcription factors and decreasing IL-8 production in H. pylori-induced gastric inflammation...
  91. ncbi Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice
    Yasushi Sawanobori
    Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Blood 111:5457-66. 2008
    ..Overall, our data established the identity and dynamics of MDSCs in a tumor-bearing host mediated by chemokines and elucidated unexpected effects of the paucity of macrophages on tumor development...
  92. ncbi Accumulation of microglial cells expressing ELR motif-positive CXC chemokines and their receptor CXCR2 in monkey hippocampus after ischemia-reperfusion
    Boryana K Popivanova
    Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Takara-machi 13-1, Japan
    Brain Res 970:195-204. 2003
    ....
  93. ncbi Protein kinase R, IkappaB kinase-beta and NF-kappaB are required for human rhinovirus induced pro-inflammatory cytokine production in bronchial epithelial cells
    Michael R Edwards
    Department of Respiratory Medicine, National Heart Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London, Norfolk Place, London W2 1PG, UK
    Mol Immunol 44:1587-97. 2007
    ..These molecules regulating rhinovirus induction of inflammation represent therapeutic targets...
  94. ncbi Essential contribution of monocyte chemoattractant protein-1/C-C chemokine ligand-2 to resolution and repair processes in acute bacterial pneumonia
    Hideaki Amano
    Department of Respiratory Medicine, Nijigaoka Hospital, 1 1 Nijigaoka, Nagasaki City, Nagasaki 852 8055, Japan
    J Immunol 172:398-409. 2004
    ..4, in a dose-dependent manner. Collectively, MCP-1/CCL2 has a crucial role in the resolution and repair processes of acute bacterial pneumonia by enhancing the removal of dying neutrophils and HGF production by AMs...
  95. ncbi Exacerbation of granuloma formation in IL-1 receptor antagonist-deficient mice with impaired dendritic cell maturation associated with Th2 cytokine production
    Hisashi Iizasa
    Department of Molecular Preventive Medicine, School of Medicine, University of Tokyo, Japan
    J Immunol 174:3273-80. 2005
    ..Thus, hepatocyte-derived IL-1ra may control optimal activation and migration of inflammatory DCs within the liver and thereby determine the local immune responses in granulomatous liver disease...