Michihiro Mieda

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi request reprint Integrative physiology of orexins and orexin receptors
    Michihiro Mieda
    Department of Molecular Neuroscience and Integrative Physiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan
    CNS Neurol Disord Drug Targets 8:281-95. 2009
  2. doi request reprint Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status
    Michihiro Mieda
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa, 920 8640, Japan
    CNS Drugs 27:83-90. 2013
  3. pmc Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep
    Michihiro Mieda
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920 8640, Japan
    J Neurosci 31:6518-26. 2011
  4. doi request reprint Bmal1 in the nervous system is essential for normal adaptation of circadian locomotor activity and food intake to periodic feeding
    Michihiro Mieda
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920 8640, Japan
    J Neurosci 31:15391-6. 2011
  5. pmc Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states
    Naoki Furutani
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
    PLoS ONE 8:e62391. 2013
  6. doi request reprint Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal
    Takeshi Sakurai
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8640, Japan
    Trends Pharmacol Sci 32:451-62. 2011
  7. doi request reprint Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation
    Shingo Soya
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920 8640, Japan
    J Neurosci 33:14549-57. 2013
  8. doi request reprint Overview of orexin/hypocretin system
    Michihiro Mieda
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
    Prog Brain Res 198:5-14. 2012
  9. doi request reprint The orexin system: roles in sleep/wake regulation
    Takeshi Sakurai
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
    Ann N Y Acad Sci 1200:149-61. 2010
  10. pmc Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice
    Koh Sasaki
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Japan
    PLoS ONE 6:e20360. 2011

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Integrative physiology of orexins and orexin receptors
    Michihiro Mieda
    Department of Molecular Neuroscience and Integrative Physiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan
    CNS Neurol Disord Drug Targets 8:281-95. 2009
    ..This review presents and discusses the current understanding of the integrative physiology of the orexin system...
  2. doi request reprint Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status
    Michihiro Mieda
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa, 920 8640, Japan
    CNS Drugs 27:83-90. 2013
    ..Thus, the discovery of a critical role played by the orexin system in the regulation of sleep/wakefulness has opened the door of a new era for sleep medicine...
  3. pmc Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep
    Michihiro Mieda
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920 8640, Japan
    J Neurosci 31:6518-26. 2011
    ..Thus, each orexin receptor subtype plays differential roles in gating NREM and REM sleep through distinct neuronal pathways...
  4. doi request reprint Bmal1 in the nervous system is essential for normal adaptation of circadian locomotor activity and food intake to periodic feeding
    Michihiro Mieda
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920 8640, Japan
    J Neurosci 31:15391-6. 2011
    ..These findings suggest that an SCN-independent FEO in the nervous system requires Bmal1 and plays a critical role in adaptation of circadian locomotor activity and food intake to periodic feeding...
  5. pmc Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states
    Naoki Furutani
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
    PLoS ONE 8:e62391. 2013
    ..These observations suggest the importance of neurotensin in maintaining activity of orexin neurons. The evidence presented here expands our understanding of the regulatory mechanism of orexin neurons...
  6. doi request reprint Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal
    Takeshi Sakurai
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8640, Japan
    Trends Pharmacol Sci 32:451-62. 2011
    ..We will also examine connections between orexin neurons and other brain areas involved in feeding behavior, reward and emotion. Finally, we will consider the therapeutic potential of drugs that target orexin receptors...
  7. doi request reprint Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation
    Shingo Soya
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920 8640, Japan
    J Neurosci 33:14549-57. 2013
    ..Especially, OX1R in LC-NA neurons plays an important role in cue-dependent fear memory formation and/or retrieval. ..
  8. doi request reprint Overview of orexin/hypocretin system
    Michihiro Mieda
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
    Prog Brain Res 198:5-14. 2012
    ..Here, we briefly summarize the progress of orexin/hypocretin studies and future perspectives...
  9. doi request reprint The orexin system: roles in sleep/wake regulation
    Takeshi Sakurai
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
    Ann N Y Acad Sci 1200:149-61. 2010
    ..In this review, we will discuss the current understanding of the physiology of the orexin system especially focusing on its roles in the regulation of sleep/wakefulness states...
  10. pmc Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice
    Koh Sasaki
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Japan
    PLoS ONE 6:e20360. 2011
    ..These findings clearly show that changes in the activity of orexin neurons can alter the behavioral state of animals and also validate this novel approach for manipulating neuronal activity in awake, freely-moving animals...
  11. pmc GABAergic neurons in the preoptic area send direct inhibitory projections to orexin neurons
    Yuki C Saito
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University Kanazawa, Japan
    Front Neural Circuits 7:192. 2013
    ..Optogenetic stimulation of these fibers resulted in rapid inhibition of orexin neurons. These observations suggest direct connectivity between POA GABAergic neurons and orexin neurons. ..
  12. pmc Differential roles of orexin receptors in the regulation of sleep/wakefulness
    Michihiro Mieda
    Department of Molecular Neuroscience and Integrative Physiology, Graduate School of Medical Science, Kanazawa University Kanazawa, Ishikawa, Japan
    Front Endocrinol (Lausanne) 4:57. 2013
    ..This review presents and discusses the current knowledge concerning the physiological roles of each orexin receptor subtype, focusing on the regulation of sleep/wakefulness...
  13. pmc Clock genes influence gene expression in growth plate and endochondral ossification in mice
    Takeshi Takarada
    Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920 1192, Japan
    J Biol Chem 287:36081-95. 2012
    ..These results suggest that endochondral ossification is under the regulation of particular clock gene products expressed in chondrocytes during postnatal skeletogenesis through a mechanism relevant to the rhythmic Ihh expression...
  14. pmc Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory
    Ruby Nagata-Kuroiwa
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Japan
    PLoS ONE 6:e16972. 2011
    ..These findings suggest important roles of NPBWR1 in regulating amygdala function during physical and social stress...