H Mabuchi

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi request reprint Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study
    Hiroshi Mabuchi
    Department of Lipidology, Kanazawa University Graduate School of Medical Science, Takara machi 13 1, Kanazawa 920 8641, Japan
    Atherosclerosis 195:e182-9. 2007
  2. ncbi request reprint An LMNA variant is associated with dyslipidemia and insulin resistance in the Japanese
    Yuko Murase
    Second Department of Internal Medicine, Kanazawa University, Ishikawa, Japan
    Metabolism 51:1017-21. 2002
  3. ncbi request reprint Genetic analysis of aldosterone synthase in patients with idiopathic hyperaldosteronism
    Y Takeda
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    J Clin Endocrinol Metab 84:1633-7. 1999
  4. ncbi request reprint Abetalipoproteinemia caused by maternal isodisomy of chromosome 4q containing an intron 9 splice acceptor mutation in the microsomal triglyceride transfer protein gene
    X P Yang
    Second Department of Internal Medicine, Department of General Medicine School of Medicine, Kanazawa University, Takara machi 13 1 Kanazawa, Ishikawa 920 8641, Japan
    Arterioscler Thromb Vasc Biol 19:1950-5. 1999
  5. ncbi request reprint Kinetic phenotypic diagnosis of N-acetylation polymorphism in patients based on ratio of urinary metabolites of salicylazosulfapyridine
    K Yokogawa
    Department of Hospital Pharmacy, School of Medicine, Kanazawa University, 13 1, Takara machi, 920 8641, Kanazawa, Japan
    Int J Pharm 229:183-91. 2001
  6. pmc A possible new syndrome with double endocrine tumors in association with an unprecedented type of familial heart-hand syndrome: a case report
    Masashi Demura
    Division of Endocrinology and Hypertension, Department of Internal Medicine, Graduate School of Medical Science, Kanazawa Universit, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    J Med Case Reports 4:347. 2010
  7. ncbi request reprint Large scale cohort study of the relationship between serum cholesterol concentration and coronary events with low-dose simvastatin therapy in Japanese patients with hypercholesterolemia and coronary heart disease: secondary prevention cohort study of the
    Hiroshi Mabuchi
    Kanazawa University Graduate School of Medicine, Japan
    Circ J 66:1096-100. 2002
  8. doi request reprint Molecular genetic epidemiology of homozygous familial hypercholesterolemia in the Hokuriku district of Japan
    Hiroshi Mabuchi
    Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Atherosclerosis 214:404-7. 2011
  9. ncbi request reprint Long-term efficacy of low-density lipoprotein apheresis on coronary heart disease in familial hypercholesterolemia. Hokuriku-FH-LDL-Apheresis Study Group
    H Mabuchi
    Second Department of Internal Medicine, Kanazawa University School of Medicine, Japan
    Am J Cardiol 82:1489-95. 1998
  10. ncbi request reprint Cutoff point separating affected and unaffected familial hypercholesterolemic patients validated by LDL-receptor gene mutants
    Hiroshi Mabuchi
    Department of Internal Medicine and Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    J Atheroscler Thromb 12:35-40. 2005

Collaborators

Detail Information

Publications144 found, 100 shown here

  1. ncbi request reprint Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study
    Hiroshi Mabuchi
    Department of Lipidology, Kanazawa University Graduate School of Medical Science, Takara machi 13 1, Kanazawa 920 8641, Japan
    Atherosclerosis 195:e182-9. 2007
    ..These changes in plasma CoQ10 levels showed no relation to the changes in serum AST, ALT and CK levels. Further studies are needed, however, for the evaluation of CoQ10 supplementation in statin therapy...
  2. ncbi request reprint An LMNA variant is associated with dyslipidemia and insulin resistance in the Japanese
    Yuko Murase
    Second Department of Internal Medicine, Kanazawa University, Ishikawa, Japan
    Metabolism 51:1017-21. 2002
    ..These results suggest the LMNA 1908C/T single nucleotide polymorphism (SNP) is not associated with the prevalence of type 2 diabetes, although it may be a factor predisposing to insulin resistance and dyslipidemia in some Japanese...
  3. ncbi request reprint Genetic analysis of aldosterone synthase in patients with idiopathic hyperaldosteronism
    Y Takeda
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    J Clin Endocrinol Metab 84:1633-7. 1999
    ..g. unidentified aldosterone-stimulating substances or abnormalities in the promoter region of the CYP11B2 gene in patients with IHA resulting in oversecretion, may cause overexpression of mRNA of CYP11B2...
  4. ncbi request reprint Abetalipoproteinemia caused by maternal isodisomy of chromosome 4q containing an intron 9 splice acceptor mutation in the microsomal triglyceride transfer protein gene
    X P Yang
    Second Department of Internal Medicine, Department of General Medicine School of Medicine, Kanazawa University, Takara machi 13 1 Kanazawa, Ishikawa 920 8641, Japan
    Arterioscler Thromb Vasc Biol 19:1950-5. 1999
    ..999). Maternal isodisomy (maternal UPD 4q) was the basis for homozygosity of the MTP gene mutation in this patient...
  5. ncbi request reprint Kinetic phenotypic diagnosis of N-acetylation polymorphism in patients based on ratio of urinary metabolites of salicylazosulfapyridine
    K Yokogawa
    Department of Hospital Pharmacy, School of Medicine, Kanazawa University, 13 1, Takara machi, 920 8641, Kanazawa, Japan
    Int J Pharm 229:183-91. 2001
    ..Thus, we were able to predict the N-acetylation polymorphic genotypes of patients by measuring the molar ratio of Ac-SP/SP in urine, after administration of SASP...
  6. pmc A possible new syndrome with double endocrine tumors in association with an unprecedented type of familial heart-hand syndrome: a case report
    Masashi Demura
    Division of Endocrinology and Hypertension, Department of Internal Medicine, Graduate School of Medical Science, Kanazawa Universit, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    J Med Case Reports 4:347. 2010
    ..The combination of a pituitary prolactinoma and an aldosterone-producing adrenal adenoma is extremely rare. To the best of our knowledge, double endocrine tumors in association with heart-hand syndrome have not previously been reported...
  7. ncbi request reprint Large scale cohort study of the relationship between serum cholesterol concentration and coronary events with low-dose simvastatin therapy in Japanese patients with hypercholesterolemia and coronary heart disease: secondary prevention cohort study of the
    Hiroshi Mabuchi
    Kanazawa University Graduate School of Medicine, Japan
    Circ J 66:1096-100. 2002
    ..A reasonable therapeutic strategy to reduce CHD progression in patients with prior CHD under low-dose statin treatment might be regulating the serum LDL-C concentration to at least <120 mg/dl and HDL-C >40 mg/dl, respectively...
  8. doi request reprint Molecular genetic epidemiology of homozygous familial hypercholesterolemia in the Hokuriku district of Japan
    Hiroshi Mabuchi
    Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Atherosclerosis 214:404-7. 2011
    ..e. LDL-receptor (LDLR), PCSK9 and apolipoprotein B (ApoB) gene. We evaluated the usefulness of DNA analysis for the diagnosis of homozygous FH (homo-FH), and studied the frequency of FH in the Hokuriku district of Japan...
  9. ncbi request reprint Long-term efficacy of low-density lipoprotein apheresis on coronary heart disease in familial hypercholesterolemia. Hokuriku-FH-LDL-Apheresis Study Group
    H Mabuchi
    Second Department of Internal Medicine, Kanazawa University School of Medicine, Japan
    Am J Cardiol 82:1489-95. 1998
    ..0088). It is concluded that LDL-apheresis is effective as treatment of CHD in FH heterozygotes, and may become the therapy of choice in severe types of FH...
  10. ncbi request reprint Cutoff point separating affected and unaffected familial hypercholesterolemic patients validated by LDL-receptor gene mutants
    Hiroshi Mabuchi
    Department of Internal Medicine and Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    J Atheroscler Thromb 12:35-40. 2005
    ..0058 for total cholesterol, and 0.9852 +/- 0.0043 for LDL-cholesterol. In conclusion, we define total cholesterol and LDL-cholesterol levels of 225 and 160 mg/dl, respectively, as cutoff points of normal subjects and FH patients...
  11. ncbi request reprint Clinical efficacy and safety of rosuvastatin in Japanese patients with heterozygous familial hypercholesterolemia
    Hiroshi Mabuchi
    Kanazawa University, Ishikawa, Japan
    J Atheroscler Thromb 11:152-8. 2004
    ..Rosuvastatin produced significant beneficial changes in all lipid parameters in Japanese patients with heterozygous familial hypercholesterolemia and was well tolerated...
  12. ncbi request reprint Clinical applications of long-term LDL-apheresis on and beyond refractory hypercholesterolemia
    Hiroshi Mabuchi
    Department of Internal Medicine, Division of Cardiovascular Genetics, Graduate School of Medical Science, Kanazawa University, Takahara machi 13 1, Kanazawa 920 8641, Japan
    Transfus Apher Sci 30:233-43. 2004
    ..Mechanisms related these clinical improvement remain unclear, and prospective randomized controlled trials should be performed for the new clinical indications of LDL-apheresis...
  13. ncbi request reprint A novel missense mutation in the myosin binding protein-C gene is responsible for hypertrophic cardiomyopathy with left ventricular dysfunction and dilation in elderly patients
    Tetsuo Konno
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    J Am Coll Cardiol 41:781-6. 2003
    ..We studied the clinical features of hypertrophic cardiomyopathy (HCM) caused by a novel mutation in the myosin binding protein-C (MyBP-C) gene in patients and family members of Japanese descent...
  14. ncbi request reprint Clinical features of hypertrophic cardiomyopathy caused by a Lys183 deletion mutation in the cardiac troponin I gene
    H Kokado
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan
    Circulation 102:663-9. 2000
    ..Previous reports have demonstrated that cardiac troponin I (cTnI) gene mutations may account for familial HCM; however, the clinical characteristics and prognosis of patients with HCM caused by cTnI gene mutations are not known...
  15. ncbi request reprint Exercise-induced ST-segment depression and systolic dysfunction in patients with nonobstructive hypertrophic cardiomyopathy
    M Shimizu
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Am Heart J 140:52-60. 2000
    ..However, it is not clear whether exercise-induced ST-segment depression in patients with HCM and patent coronary arteries is associated with changes in left ventricular function...
  16. ncbi request reprint Diagnostic usefulness of the post-exercise systolic blood pressure response for the detection of coronary artery disease in patients with diabetes mellitus
    M Yamaguchi
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Jpn Circ J 64:949-52. 2000
    ..These results suggest that calculating the SBP ratio, in combination with monitoring for ST depression, improves the accuracy of treadmill exercise testing for the detection of CAD in patients with DM...
  17. ncbi request reprint Coronary lesion morphology and prognosis in young males with myocardial infarction with or without familial hypercholesterolemia
    T Yasuda
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Jpn Circ J 65:247-50. 2001
    ..These results suggest that the mechanism of AMI in young male patients with FH differs from that in similar aged patients without FH, and that the overall prognosis of these patients is less favorable...
  18. ncbi request reprint Cardiac dysfunction and long-term prognosis in patients with nonobstructive hypertrophic cardiomyopathy and abnormal (123)I-15- (p-Iodophenyl)-3(R,S)-methylpentadecanoic acid myocardial scintigraphy
    M Shimizu
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan
    Cardiology 93:43-9. 2000
    ..4% in group A and 14.6% in group B (p < 0.01). These results suggest that patients with HCM and moderate to large defects as assessed by BMIPP myocardial scintigraphy have decreased cardiac function and a poor prognosis...
  19. ncbi request reprint Left ventricular systolic dysfunction during exercise and dobutamine stress in patients with hypertrophic cardiomyopathy
    K Okeie
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    J Am Coll Cardiol 36:856-63. 2000
    ..We sought to characterize stress-induced left ventricular systolic dysfunction in patients with hypertrophic cardiomyopathy (HCM)...
  20. ncbi request reprint Comparison of effects of pitavastatin and atorvastatin on plasma coenzyme Q10 in heterozygous familial hypercholesterolemia: results from a crossover study
    M A Kawashiri
    Division of Cardiovascular Medicine, Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Clin Pharmacol Ther 83:731-9. 2008
    ..39), although no adverse events or abnormalities of liver and muscle enzyme were observed after either statin treatment. It remains to be seen whether the observed changes in CoQ10 levels are related to the long-term safety of this drug...
  21. ncbi request reprint Cardiac aldosterone production in genetically hypertensive rats
    Y Takeda
    Second Department of Internal Medicine, Department of Health Sciences, School of Medicine, Kanazawa University, Kanazawa, Japan
    Hypertension 36:495-500. 2000
    ..These results suggest that the rat heart produces aldosterone and that endogenous cardiac aldosterone may affect cardiac function and hypertrophy in hypertension in rats...
  22. ncbi request reprint Hyperhomocysteinemia, diabetes mellitus, and carotid atherosclerosis independently increase atherosclerotic vascular disease outcome in Japanese patients with end-stage renal disease
    T Haraki
    Department of Internal Medicine, Fukui Prefectural Hospital, Japan
    Clin Nephrol 56:132-9. 2001
    ..Patients with end-stage renal disease (ESRD) have high mortality from atherosclerotic/atherothrombotic vascular disease (AVD). However, the role of an elevated plasma total homocysteine (tHcy) level as a risk factor is uncertain in ESRD...
  23. ncbi request reprint Increased QT dispersion does not reflect the increased regional variation of cardiac sympathetic nervous activity in hypertrophic cardiomyopathy
    M Shimizu
    Second Department of Internal Medicine, Kanazawa University, Takara machi 13 1, Kanazawa 920 8640, Japan
    Am Heart J 142:358-62. 2001
    ..However, the relationship between QTD and the regional variation of cardiac sympathetic nerve activity in hypertrophic cardiomyopathy (HCM) is not yet elucidated...
  24. ncbi request reprint The relationship of serum lipoprotein lipase mass with fasting serum apolipoprotein B-48 and remnant-like particle triglycerides in type 2 diabetic patients
    J Kobayashi
    Department of Lipidology, Kanazawa University Graduate School of Medical Science, and Department of General Medicine, Kanazawa University Hospital, Japan
    Horm Metab Res 39:612-6. 2007
    ..In this study, we have clarified the relationships of LPL mass in pre-heparin with serum apo B-48 measured by enzyme-linked immunosorbent assay, triglycerides (TG), and remnant-like particle triglycerides (RLP-TG)...
  25. ncbi request reprint Mechanisms of FK 506-induced hypertension in the rat
    Y Takeda
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan
    Hypertension 33:130-6. 1999
    ..kg-1. d-1) prevented FK 506-induced hypertension in rats. These results indicate that FK 506 may increase blood pressure not only by increasing ET-1 production but also by decreasing NO synthesis in the vasculature...
  26. ncbi request reprint Systolic dysfunction and blood pressure responses to supine exercise in patients with hypertrophic cardiomyopathy
    M Shimizu
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Jpn Circ J 65:325-9. 2001
    ..005). These results suggest that exercise-induced systolic dysfunction in patients with non-obstructive HCM may contribute to abnormal blood pressure response in those patients...
  27. ncbi request reprint Acute increases in plasma oxidized low-density lipoprotein immediately after percutaneous transluminal coronary angioplasty
    H Fujii
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Am J Cardiol 87:102-3, A8. 2001
    ..Plasma oxidized low-density lipoprotein levels were significantly increased immediately after coronary angioplasty in patients with stable angina pectoris as well as in those with acute coronary syndromes...
  28. ncbi request reprint Phenotypic differences between electrocardiographic and echocardiographic determination of hypertrophic cardiomyopathy in genetically affected subjects
    T Konno
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa, Japan
    J Intern Med 258:216-24. 2005
    ..The goal of this study was to evaluate the diagnostic value of ECG for detecting carriers without LVH, and also to assess normal ECG patterns in carriers with LVH from the genetic standpoint of HCM...
  29. ncbi request reprint Catalytically inactive lecithin: cholesterol acyltransferase (LCAT) caused by a Gly 30 to Ser mutation in a family with LCAT deficiency
    X P Yang
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Ishikawa, Japan
    J Lipid Res 38:585-91. 1997
    ..Thus, the N-terminal domain appears crucial for enzymatic activity, in addition to the catalytically active consensus sequence of Gly179 to Gly183 and a putative sterol binding domain of Glu154 to Lys173...
  30. ncbi request reprint Cardiac troponin T Arg92Trp mutation and progression from hypertrophic to dilated cardiomyopathy
    N Fujino
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Clin Cardiol 24:397-402. 2001
    ..Early identification of individuals with this mutation may provide the opportunity to evaluate the efficacy of early therapeutic interventions...
  31. ncbi request reprint Cholesteryl ester transfer protein and atherosclerosis
    A Inazu
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Curr Opin Lipidol 11:389-96. 2000
    ..In hypercholesterolaemia or combined hyperlipidaemia, plasma cholesteryl ester transfer protein may be pro-atherogenic and could be a therapeutic target...
  32. ncbi request reprint Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG
    Kenshi Hayashi
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Clin Sci (Lond) 107:175-82. 2004
    ....
  33. ncbi request reprint Effects of NK-104, a new hydroxymethylglutaryl-coenzyme reductase inhibitor, on low-density lipoprotein cholesterol in heterozygous familial hypercholesterolemia. Hokuriku NK-104 Study Group
    K Kajinami
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Am J Cardiol 85:178-83. 2000
    ....
  34. doi request reprint Association of angiopoietin-like protein 3 with hepatic triglyceride lipase and lipoprotein lipase activities in human plasma
    K Nakajima
    Department of Lipidology and Division of Cardiology, Kanazawa University Graduate School of Medical Science, Kanazawa City, Ishikawa, Japan
    Ann Clin Biochem 47:423-31. 2010
    ....
  35. ncbi request reprint Effect of adrenocorticotropin stimulation on the synthesis of 19-noraldosterone in man
    Y Takeda
    Second Department of Internal Medicine, Kanazawa University School of Medicine, Japan
    J Clin Endocrinol Metab 81:1852-5. 1996
    ..These observations suggest that 19-noraldosterone is stimulated by the renin-angiotensin system as well as ACTH...
  36. ncbi request reprint Circulating matrix metalloproteinases and their inhibitors in premature coronary atherosclerosis
    Y Noji
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Clin Chem Lab Med 39:380-4. 2001
    ....
  37. ncbi request reprint Changes in cardiac tissue characterization in carriers with gene mutations associated with hypertrophic cardiomyopathy
    Tomoya Kaneda
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8640, Japan
    Int J Cardiol 104:170-5. 2005
    ..Early detection in patients with hypertrophic cardiomyopathy (HCM) is very important. Integrated backscatter (IB) provides a useful noninvasive measure of the acoustic properties of the myocardium, and may detect early myocardial changes...
  38. ncbi request reprint Effects of angiotensin-converting enzyme inhibitor and aldosterone antagonist on myocardial collagen in cardiomyopathic hamsters
    T Araki
    2nd Department of Internal Medicine, Kanazawa University School of Medicine, Japan
    Jpn Circ J 59:213-8. 1995
    ....
  39. ncbi request reprint Opposite effects on serum cholesteryl ester transfer protein levels between long-term treatments with pravastatin and probucol in patients with primary hypercholesterolemia and xanthoma
    A Inazu
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Takara machi, Japan
    Atherosclerosis 145:405-13. 1999
    ..In addition, higher levels of serum HDL3 triglyceride on lipid-lowering therapy (6 months) appear to be a common predictor of regression of Achilles' tendon xanthoma in the treatment with either pravastatin or probucol...
  40. ncbi request reprint Coronary ectasia in familial hypercholesterolemia: histopathologic study regarding matrix metalloproteinases
    K Kajinami
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Mod Pathol 12:1174-80. 1999
    ..These observations suggest that the MMP-TIMP system appears to play a significant role in the development of coronary ectasia..
  41. ncbi request reprint Effects of high sodium intake on cardiovascular aldosterone synthesis in stroke-prone spontaneously hypertensive rats
    Y Takeda
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    J Hypertens 19:635-9. 2001
    ..The goal of this study was to determine whether high salt intake increases cardiovascular aldosterone synthesis in SHRSP...
  42. ncbi request reprint Arrhythmias in patients with Brugada-type electrocardiographic findings
    H Itoh
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Jpn Circ J 65:483-6. 2001
    ....
  43. ncbi request reprint Coronary calcification and coronary atherosclerosis: site by site comparative morphologic study of electron beam computed tomography and coronary angiography
    K Kajinami
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    J Am Coll Cardiol 29:1549-56. 1997
    ..We compared, on a site by site basis, the morphologic features of coronary calcifications determined by electron beam computed tomography (EBCT) and angiographically defined coronary atherosclerosis...
  44. ncbi request reprint Association of LMNA 1908C/T polymorphism with cerebral vascular disease and diabetic nephropathy in Japanese men with type 2 diabetes
    Hua Liang
    The Second Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Ishikawa, Japan
    Clin Endocrinol (Oxf) 63:317-22. 2005
    ..The aim of this study therefore was to investigate the association between the LMNA 1908C/T polymorphism and the prevalence of vascular disease in Japanese patients with type 2 diabetes...
  45. ncbi request reprint Q-T peak dispersion in congenital long QT syndrome: possible marker of mutation of HERG
    Masaru Inoue
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Japan
    Circ J 67:495-8. 2003
    ..These results suggest that increased lag of the peak of the T wave in each precordial lead (QTpc dispersion) may be a possible index to differentiate LQTS patients with HERG mutation from those with KCNQ1 mutation...
  46. ncbi request reprint Detailed analysis of serum lipids and lipoproteins from Japanese type III hyperlipoproteinemia with apolipoprotein E2/2 phenotype
    Yasuhiro Todo
    Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    Clin Chim Acta 348:35-40. 2004
    ..To clarify a detailed profile of serum lipids, lipoproteins and apolipoproteins (apo) in type III hyperlipoproteinemia (HLP) with apolipoprotein E (apo E) phenotype 2/2...
  47. ncbi request reprint Compound heterozygosity for mutations Asp611-->Tyr in KCNQ1 and Asp609-->Gly in KCNH2 associated with severe long QT syndrome
    Masato Yamaguchi
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    Clin Sci (Lond) 108:143-50. 2005
    ..Our results suggest that the mild phenotype produced by the D611Y mutation in KCNQ1 became more serious by addition of the D609G mutation in KCNH2 in the proband...
  48. ncbi request reprint Relationship of lipoprotein lipase and hepatic triacylglycerol lipase activity to serum adiponectin levels in Japanese hyperlipidemic men
    J Kobayashi
    Department of Lifestyle related Disease, Kanazawa University Graduate School of Medical Science, Takara machi 13 1, Japan
    Horm Metab Res 37:505-9. 2005
    ..The aim of this study was to determine how lipoprotein lipase (LPL) and hepatic triacylglycerol lipase (HTGL) activity relate to serum adiponectin levels...
  49. ncbi request reprint Enhanced cholesteryl ester transfer protein activities and abnormalities of high density lipoproteins in familial hypercholesterolemia
    A Inazu
    Second Department of Internal Medicine, School of Medicine, University of Kanazawa, Japan
    Horm Metab Res 24:284-8. 1992
    ..334, p less than 0.05). These results indicate that the enhanced CETP activities may contribute to increase risk for developing atherosclerosis in FH by changing the distribution of cholesteryl ester in serum lipoproteins...
  50. ncbi request reprint Iron accumulation in the liver of male patients with Wilson's disease
    Y Shiono
    Department of Medicine, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan
    Am J Gastroenterol 96:3147-51. 2001
    ..Subsequent iron reduction by phlebotomy ameliorated their biochemical liver damage. CONCLUSION: Iron overload related to hypoceruloplasminemia may be clinically important, particularly in male patients with Wilson's disease...
  51. ncbi request reprint Fatal cardiac beta2-microglobulin amyloidosis in patients on long-term hemodialysis
    M Kawano
    Pathology Section, Kanazawa University Hospital, Kanazawa, and Naruwa Hospital, Kanazawa, Japan
    Am J Kidney Dis 31:E4. 1998
    ..We conclude that cardiac dialysis-related amyloidosis should also be considered in long-term hemodialysis patients with congestive heart failure as a life-threatening complication...
  52. ncbi request reprint Quantitative assessment of diffuse coronary artery disease using a three-dimensional reconstruction method compared with intravascular ultrasound images
    T Tsuchiya
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Coron Artery Dis 12:127-33. 2001
    ..980). CONCLUSIONS: These observations validate a novel approach to quantifying diffuse CAD using clinical arteriograms...
  53. ncbi request reprint Haplotype analyses of cholesteryl ester transfer protein gene promoter: a clue to an unsolved mystery of TaqIB polymorphism
    Hong Lu
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, 920 8641, Kanazawa, Japan
    J Mol Med (Berl) 81:246-55. 2003
    ....
  54. doi request reprint Impacts of visceral adipose tissue and subcutaneous adipose tissue on metabolic risk factors in middle-aged Japanese
    Rie Oka
    Department of Internal Medicine, Hokuriku Central Hospital, Toyama, Japan
    Obesity (Silver Spring) 18:153-60. 2010
    ..VAT showed dominant impacts on triglyceride concentrations in both genders and on HDL-cholesterol in women, while SAT also had an independent association with blood pressure...
  55. ncbi request reprint Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients
    Hiroshi Mabuchi
    Dept of Internal Medicine and Molecular Genetics of Cardiovascular Disorders, Div of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Takara machi 13 1, Kanazawa, Ishikawa 920 8641, Japan
    J Atheroscler Thromb 12:111-9. 2005
    ..627, p = 0.0165). As atorvastatin reduces serum ubiquinol-10 as well as serum cholesterol levels in all patients, it is imperative that physicians are forewarned about the risks associated with ubiquinol-10 depletion...
  56. ncbi request reprint Double deletions and missense mutations in the first nucleotide-binding fold of the ATP-binding cassette transporter A1 ( ABCA1) gene in Japanese patients with Tangier disease
    Zhigang Guo
    Molecular Genetics of Cardiovascular Disorders, Vascular Medicine, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Hum Genet 47:325-9. 2002
    ..The third patient was homozygous for A3199G of exon 19 that leads to Asn935Ser, which is the same mutation found in German and Spanish families. Both Asn mutations involved Walker A motif of the first nucleotide-binding fold...
  57. ncbi request reprint Clinical efficacy of pitavastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in patients with hyperlipidemia. Dose-finding study using the double-blind, three-group parallel comparison
    Yasushi Saito
    Second Department of Internal Medicine, School of Medicine, Chiba University, Chiba, Japan
    Arzneimittelforschung 52:251-5. 2002
    ..It also significantly decreased the serum levels of triglycerides (TG) within this dose range. There was no dose-dependence of the incidence of adverse reactions to pitavastatin...
  58. ncbi request reprint Mutational analysis of ATP7B and genotype-phenotype correlation in Japanese with Wilson's disease
    T Okada
    The 2nd Department of Internal Medicine, Kanazawa University, School of Medicine, Ishikawa, Japan
    Hum Mutat 15:454-62. 2000
    ..6% and 35. 0% of heterozygotes, respectively. When patients and their families are screened for WD, a high rate of abnormal laboratory data in heterozygotes must be taken into account...
  59. ncbi request reprint PRKAR1A gene mutation in patients with cardiac myxoma
    T Mabuchi
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8640, Japan
    Int J Cardiol 102:273-7. 2005
    ..We hypothesized that cardiac myxoma may be associated with PRKAR1A gene mutation and determined whether mutation in the PRKAR1A gene is the cause of familial and sporadic cardiac myxoma...
  60. ncbi request reprint Effect of bilirubin UDP glucuronosyltransferase 1 gene TATA box genotypes on serum bilirubin concentrations in chronic liver injuries
    H Doyama
    Second Department of Internal Medicine, Kanazawa University School of Medicine, Ishikawa, Japan
    Hepatology 32:563-8. 2000
    ..TATA box genotypes should therefore be considered when evaluating hepatic function by serum bilirubin concentrations in cases of hepatitis C-associated chronic liver diseases...
  61. ncbi request reprint Effect of common methylenetetrahydrofolate reductase gene mutation on coronary artery disease in familial hypercholesterolemia
    M Kawashiri
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan
    Am J Cardiol 86:840-5. 2000
    ..Thus, the MTHFR mutation appears to accelerate the onset of CAD through elevation of plasma homocysteine levels in male heterozygous patients with FH...
  62. ncbi request reprint Collagen remodeling and cardiac dysfunction in patients with hypertrophic cardiomyopathy: the significance of type III and VI collagens
    M Kitamura
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Clin Cardiol 24:325-9. 2001
    ..Increases in the percentage of type III and VI collagen correlate with cardiac dysfunction...
  63. ncbi request reprint Effects of hepatic lipase gene promoter nucleotide variations on serum HDL cholesterol concentration in the general Japanese population
    A Inazu
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    J Hum Genet 46:172-7. 2001
    ..These genetic attributes may be among the many factors that contribute to the relatively higher serum HDL-C levels in Japanese subjects...
  64. ncbi request reprint Genetic analysis of the cytochrome P-450c17alpha (CYP17) and aldosterone synthase (CYP11B2) in Japanese patients with 17alpha-hydroxylase deficiency
    Y Takeda
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Third Department of Internal Medicine, Fukui Medical School, Fukui and Koseiren Takaoka Hospital, Takaoka, Japan
    Clin Endocrinol (Oxf) 54:751-8. 2001
    ..Next, to clarify the mechanism of hypoaldosteronism in 17alpha-hydroxylase deficiency, we analysed the expression of aldosterone synthase (CYP11B2) messenger RNA and sequenced CYP11B2 in these patients...
  65. ncbi request reprint The relationship between post-prandial plasma glucose and post-challenge plasma glucose in Japanese population
    Rie Oka
    Department of Internal Medicine, Hokuriku Central Hospital of Japan Mutual Aid Association of Public School Teachers, 123 Nodera, Oyabe, Toyama 932 8503, Japan
    Diabetes Res Clin Pract 78:282-8. 2007
    ..In evaluating PPG2h, if the cutoff point of 140 mg/dl (7.8 mmol/l) for PCG2h is extrapolated, the majority of subjects with dysglycemia could be overlooked...
  66. ncbi request reprint A novel mutation Lys273Glu in the cardiac troponin T gene shows high degree of penetrance and transition from hypertrophic to dilated cardiomyopathy
    Noboru Fujino
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan
    Am J Cardiol 89:29-33. 2002
    ..Because the location of a mutation appears to influence the development of a phenotype, we suggest that the precise definition of the disease-causing mutation can provide important prognostic information about affected members...
  67. ncbi request reprint Cardiac sympathetic nerve activity in patients with hypertrophic cardiomyopathy with malignant ventricular tachyarrhythmias
    Hidenobu Terai
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    J Nucl Cardiol 10:304-10. 2003
    ..4 +/- 5.7%, P <.0001), although other parameters including heterogeneity indices did not differ. The logistic multiple regression analysis also determined that washout rate was the most powerful predictor of VT in patients with HCM...
  68. ncbi request reprint High incidence of sudden cardiac death with conduction disturbances and atrial cardiomyopathy caused by a nonsense mutation in the STA gene
    Kenji Sakata
    Department of Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Takara machi, Ishikawa, Japan
    Circulation 111:3352-8. 2005
    ..Although it has been reported that EDMD caused by the STA gene mutation is associated with X-linked recessive inheritance, the genotype-phenotype correlations, with special reference to cardiac manifestations, are not well defined...
  69. ncbi request reprint CETP (cholesteryl ester transfer protein) promoter -1337 C>T polymorphism protects against coronary atherosclerosis in Japanese patients with heterozygous familial hypercholesterolaemia
    Mutsuko Takata
    Molecular Genetics of Cardiovascular Disorders, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8641, Japan
    Clin Sci (Lond) 111:325-31. 2006
    ..022; P=0.0256). These results indicate that the CETP promoter -1337C>T polymorphism is associated with the progression of coronary atherosclerosis in Japanese patients with FH, independent of HDL-C and triacylglycerol levels...
  70. ncbi request reprint ATP-binding cassette transporter G8 M429V polymorphism as a novel genetic marker of higher cholesterol absorption in hypercholesterolaemic Japanese subjects
    Kenji Miwa
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiology, Graduate School of Medical Science, Kanazawa University, Japan
    Clin Sci (Lond) 109:183-8. 2005
    ..Future studies should investigate whether these findings have implications for the optimal cholesterol-lowering drug treatment in hypercholesterolaemic patients...
  71. ncbi request reprint Cholesteryl ester transfer protein inhibitor (JTT-705) and the development of atherosclerosis in rabbits with severe hypercholesterolaemia
    Zhiping Huang
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8641, Japan
    Clin Sci (Lond) 103:587-94. 2002
    ....
  72. ncbi request reprint New variant of low density lipoprotein receptor gene. FH-Tonami
    K Kajinami
    Second Department of Internal Medicine, Kanazawa University School of Medicine, Ishikawa, Japan
    Arteriosclerosis 8:187-92. 1988
    ..Neonatal diagnosis of FH in two fetuses from one family was possible through analyses of their LDLR genes in cord blood samples at delivery...
  73. ncbi request reprint Therapeutic effects of LDL apheresis in the prevention of atherosclerosis
    K Kajinami
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Curr Opin Lipidol 10:401-6. 1999
    ..Since the mechanisms of clinical improvement caused by LDL apheresis extend beyond simple and drastic reduction of LDL cholesterol, further investigation based on recent vascular biological evidence is needed...
  74. ncbi request reprint Right ventricular metastasis from a primary cervical carcinoma
    T Iwaki
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan
    Jpn Circ J 65:761-3. 2001
    ..Despite radiotherapy and chemotherapy, the patient died. At autopsy, the metastatic deposit in the heart was larger than the primary cervical carcinoma...
  75. ncbi request reprint Effects of raloxifene on adipocytokines in Japanese osteoporotic postmenopausal women with and without type 2 diabetes
    Y Murase
    Department of Molecular Genetics of Cardiovascular Disorders, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan
    Horm Metab Res 38:130-3. 2006
  76. ncbi request reprint Efficacy of colestimide coadministered with atorvastatin in japanese patients with heterozygous familial hypercholesterolemia (FH)
    Masa aki Kawashiri
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Disease, Graduate School of Kanazawa University
    Circ J 69:515-20. 2005
    ..Moreover, colestimide has excellent patient compliance because it is available in tablet form...
  77. ncbi request reprint Type III hyperlipoproteinemia exaggerated by Sheehan's syndrome with advanced systemic atherosclerosis: a 28-year clinical course
    Masa aki Kawashiri
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Disease, Kanazawa, Japan
    Circ J 69:746-51. 2005
    ..These findings suggest that the continuous elevation of intermediate-density lipoprotein cholesterol for a long period contributed to the development of the atherosclerotic lesions...
  78. ncbi request reprint Electrocardiographic events and cholesterol reduction with pravastatin in patients with hypercholesterolemia: the Hokuriku Lipid Coronary Heart Disease Study-Pravastatin Atherosclerosis Trial
    Masami Shimizu
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8640, Japan
    Int J Cardiol 99:395-401. 2005
    ..Cholesterol lowering therapy may offset the development of coronary atherosclerosis, and the resulting reduction in coronary ischemia may be observed in the electrocardiogram (ECG)...
  79. ncbi request reprint Scintigraphic evaluation of regression of abnormal Q waves in myocardial infarction
    Tetsuo Konno
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8640, Japan
    Ann Nucl Med 19:407-9. 2005
    ..Scintigraphic findings in the present case here may contribute to an interpretation of regression of abnormal Q waves in myocardial infarction...
  80. ncbi request reprint Abnormal sympathetic innervation of the heart in a patient with Emery-Dreifuss muscular dystrophy
    Takashi Fujiita
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Ann Nucl Med 19:411-4. 2005
    ..Six months later, his LV wall motion on echocardiograms developed diffuse hypokinesis. These results suggest that the abnormality on I-123 MIBG myocardial scintigrams may predict LV dysfunction in Emery-Dreifuss muscular dystrophy...
  81. ncbi request reprint Long-term course of lipoprotein lipase (LPL) deficiency due to homozygous LPL(Arita) in a patient with recurrent pancreatitis, retained glucose tolerance, and atherosclerosis
    Masa aki Kawashiri
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Disease, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    J Clin Endocrinol Metab 90:6541-4. 2005
    ..Patients with LPL deficiency suffer from the frequent recurrence of acute pancreatitis, but the underlying mechanisms are not fully understood...
  82. doi request reprint The E32K variant of PCSK9 exacerbates the phenotype of familial hypercholesterolaemia by increasing PCSK9 function and concentration in the circulation
    Tohru Noguchi
    Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8640, Japan
    Atherosclerosis 210:166-72. 2010
    ..We attempted to find gain-of-function PCSK9 mutations in Japanese subjects and determine the frequency and impacts of these mutations, especially on circulating PCSK9 and LDL-C levels...
  83. ncbi request reprint Retinoid X receptor heterodimer variants and cardiovascular risk factors
    Atsushi Nohara
    Departments of Lipidology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Atheroscler Thromb 16:303-18. 2009
    ....
  84. ncbi request reprint Marked aortic valve stenosis progression after receiving long-term aggressive cholesterol-lowering therapy using low-density lipoprotein apheresis in a patient with familial hypercholesterolemia
    Masayuki Tsuchida
    Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Circ J 73:963-6. 2009
    ..These findings suggest that careful attention to the progression of aortic valve stenosis is needed for extreme hypercholesterolemic patients even under optimal cholesterol-lowering therapy for the secondary prevention of CAD...
  85. ncbi request reprint Reassessment of the cutoff values of waist circumference and visceral fat area for identifying Japanese subjects at risk for the metabolic syndrome
    Rie Oka
    Department of Internal Medicine, Hokuriku Central Hospital of Japan Mutual Aid Association of Public School Teachers, 123 Nodera, Oyabe, Toyama 932 8503, Japan
    Diabetes Res Clin Pract 79:474-81. 2008
    ..In conclusion, setting the cutoff points of WC and VFA lower values in women than in men for the definition of central obesity is needed to identify the subjects with MetS in Japanese, as in other Asian populations...
  86. ncbi request reprint Generation and gender differences in the components contributing to the diagnosis of the metabolic syndrome according to the Japanese criteria
    Junji Kobayashi
    Department of Lipidology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Circ J 71:1734-7. 2007
    ..To clarify whether there are age and gender differences in the components contributing to the diagnosis of metabolic syndrome (MS) in the Japanese population...
  87. ncbi request reprint Septal wall thinning and systolic dysfunction in patients with hypertrophic cardiomyopathy caused by a cardiac troponin I gene mutation
    Masami Shimizu
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Japan
    Am Heart J 143:690-5. 2002
    ..However, the clinical course and determinants of poor prognosis in patients with this mutation have not been well established...
  88. ncbi request reprint Decreased post-prandial triglyceride response and diminished remnant lipoprotein formation in cholesteryl ester transfer protein (CETP) deficiency
    Akihiro Inazu
    Department of Laboratory Science, Graduate School of Medical Science, Kanazawa University, Kodatsuno 5 11 80, Kanazawa, Ishikawa 920 0942, Japan
    Atherosclerosis 196:953-7. 2008
    ..Subjects with CETP deficiency appeared to have low levels of TG response and diminished remnant lipoprotein formation after fat-load...
  89. ncbi request reprint Association of genetic variation of the adiponectin gene with body fat distribution and carotid atherosclerosis in Japanese obese subjects
    Yuko Katsuda
    Molecular Genetics of Cardiovascular Disorders, Graduate School of Medical Science, Kanazawa University, Japan
    J Atheroscler Thromb 14:19-26. 2007
    ..The aim of this study was to investigate the effect of SNP45 of the adiponectin gene on body fat distribution and carotid atherosclerosis in Japanese obese subjects...
  90. ncbi request reprint Serum lipoprotein lipase mass: clinical significance of its measurement
    Junji Kobayashi
    Department of Lipidology, Kanazawa University Graduate School of Medical Science Takara machi 13 1, Kanazawa 920 8640, and Department of General Medicine, Kanazawa University Hospital, Japan
    Clin Chim Acta 378:7-12. 2007
    ..Taken together, we suggest that pre-heparin LPL mass in plasma or sera provide us with useful and important information on the development of metabolic disorders leading to atherosclerotic disease...
  91. ncbi request reprint Effect of walking with a pedometer on serum lipid and adiponectin levels in Japanese middle-aged men
    Junji Kobayashi
    Department of Lifestyle related Disease, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Atheroscler Thromb 13:197-201. 2006
    ..To clarify the effects of walking with a pedometer on metabolic parameters, including adiponectin (APN)...
  92. ncbi request reprint High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia
    Atsushi Nohara
    Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8641, Japan
    Arterioscler Thromb Vasc Biol 27:923-8. 2007
    ..Because several nuclear receptors play pivotal roles in lipid metabolism, we tested the hypothesis that genetic variants of nuclear receptors contribute to FCHL...
  93. ncbi request reprint Differences in diagnostic value of four electrocardiographic voltage criteria for hypertrophic cardiomyopathy in a genotyped population
    Tetsuo Konno
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Am J Cardiol 96:1308-12. 2005
    ..Therefore, understanding the diagnostic value of classic ECG voltage criteria may be important in detecting carriers, including those without left ventricular hypertrophy...
  94. ncbi request reprint Risk evaluation of coronary heart disease and cerebrovascular disease by the Japan Atherosclerosis Society Guidelines 2002 using the cohort of the Holicos-PAT study
    Junji Koizumi
    Department of Internal Medicine, School of Medicine, Kanazawa University, Ishikawa, Japan
    J Atheroscler Thromb 12:48-52. 2005
    ..However, the risk evaluation by the JAS guideline categories may underestimate the risk in men and overestimate it in women...
  95. ncbi request reprint Association between CTLA-4 +49 A/G polymorphism and type 1B diabetes in Japanese population
    Hua Liang
    Second Department of Internal Medicine, Kanazawa University, Ishikawa, Japan
    Endocrine 25:105-9. 2004
    ....
  96. ncbi request reprint Characterization of a novel missense mutation E637K in the pore-S6 loop of HERG in a patient with long QT syndrome
    Kenshi Hayashi
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University 13 1, Takara machi, Ishikawa 920 8640, Japan
    Cardiovasc Res 54:67-76. 2002
    ..Therefore, we investigated the role of a glutamic acid at the vicinity of the pore in HERG channels by mutating it to a lysine...
  97. ncbi request reprint Autopsy findings in siblings with hypertrophic cardiomyopathy caused by Arg92Trp mutation in the cardiac troponin T gene showing dilated cardiomyopathy-like features
    Masami Shimizu
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Clin Cardiol 26:536-9. 2003
    ..Although some patients with HCM have shown dilated cardiomyopathy (DCM)-like features, the relationship between genotype and histologic findings is not well known...
  98. ncbi request reprint Long-term effect of low-density lipoprotein apheresis in patients with heterozygous familial hypercholesterolemia
    Toshinori Higashikata
    The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan
    Ther Apher Dial 7:402-7. 2003
    ....
  99. ncbi request reprint T wave peak-to-end interval and QT dispersion in acquired long QT syndrome: a new index for arrhythmogenicity
    Masato Yamaguchi
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8640, Japan
    Clin Sci (Lond) 105:671-6. 2003
    ..28 is a good cut-off point for TdP. Tpe did not correlate with the corrected maximum QT interval, whereas the QTDc did correlate with this parameter. In conclusion, Tpe may be the best predictor for TdP in patients with acquired LQTS...
  100. ncbi request reprint Diagnostic value of abnormal Q waves for identification of preclinical carriers of hypertrophic cardiomyopathy based on a molecular genetic diagnosis
    Tetsuo Konno
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa Japan
    Eur Heart J 25:246-51. 2004
    ..The aim of this study was to determine the most accurate diagnostic definition of abnormal Q waves for HCM based on a molecular genetic diagnosis, and also to apply abnormal Q waves to the identification of preclinical carriers...
  101. ncbi request reprint Chronologic electrocardiographic changes in patients with hypertrophic cardiomyopathy associated with cardiac troponin 1 mutation
    Masami Shimizu
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Am Heart J 143:289-93. 2002
    ..Deletion of lysine 183 (K183del) in the cardiac troponin I (cTnI) gene is one of the mutations that causes hypertrophic cardiomyopathy (HCM). However, the phenotypic expression of this mutation has not been well established...