Satoru Kyo

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. doi request reprint Experience and efficacy of a bipolar vessel sealing system for radical abdominal hysterectomy
    Satoru Kyo
    Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan
    Int J Gynecol Cancer 19:1658-61. 2009
  2. doi request reprint Massive hemothorax due to diaphragmatic endometriosis after a laparoscopic cystectomy of an ovarian endometrioma in a patient without a history of thoracic endometriosis
    Satoru Kyo
    Department of Obstetrics and Gynecology, Kanazawa University School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Arch Gynecol Obstet 286:411-4. 2012
  3. ncbi request reprint Telomerase activity in human endometrium
    S Kyo
    Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University, Ishikawa, Japan
    Cancer Res 57:610-4. 1997
  4. ncbi request reprint How to inhibit telomerase activity for cancer therapy
    Satoru Kyo
    Department of Obstetrics and Gynecology, Kanazawa University, School of Medicine, 13 1, Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Curr Med Chem Anticancer Agents 2:613-26. 2002
  5. doi request reprint Forkhead transcription factor FOXO1 is a direct target of progestin to inhibit endometrial epithelial cell growth
    Satoru Kyo
    Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Clin Cancer Res 17:525-37. 2011
  6. pmc Significance of immunological detection of human telomerase reverse transcriptase: re-evaluation of expression and localization of human telomerase reverse transcriptase
    Satoru Kyo
    Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 163:859-67. 2003
  7. doi request reprint Stem cells in endometrium and endometrial cancer: accumulating evidence and unresolved questions
    Satoru Kyo
    Department of Obstetrics and Gynecology, Kanazawa University, Graduate School of Medical Science, Japan
    Cancer Lett 308:123-33. 2011
  8. ncbi request reprint High Twist expression is involved in infiltrative endometrial cancer and affects patient survival
    Satoru Kyo
    Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Hum Pathol 37:431-8. 2006
  9. ncbi request reprint Complex regulatory mechanisms of telomerase activity in normal and cancer cells: how can we apply them for cancer therapy?
    Satoru Kyo
    Department of Obstetrics and Gynecology, Kanazawa University, School of Medicine, Japan
    Oncogene 21:688-97. 2002
  10. ncbi request reprint Telomerase activity in cancer as a diagnostic and therapeutic target
    S Kyo
    Department of Obstetrics and Gynecology, Kanazawa University, School of Medicine, Takaramachi, Ishikawa, Japan
    Histol Histopathol 15:813-24. 2000

Collaborators

Detail Information

Publications83

  1. doi request reprint Experience and efficacy of a bipolar vessel sealing system for radical abdominal hysterectomy
    Satoru Kyo
    Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan
    Int J Gynecol Cancer 19:1658-61. 2009
    ..31 +/- 2.22 mg/dL vs 3.22 +/- 1.11 mg/dL; P < 0.05). These findings indicate that the LigaSure vessel sealing system is useful to reduce blood loss and shorten operating time at RAH...
  2. doi request reprint Massive hemothorax due to diaphragmatic endometriosis after a laparoscopic cystectomy of an ovarian endometrioma in a patient without a history of thoracic endometriosis
    Satoru Kyo
    Department of Obstetrics and Gynecology, Kanazawa University School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Arch Gynecol Obstet 286:411-4. 2012
    ..Severe hemothorax is a rare complication after laparoscopic surgery for endometriosis, and the causes and proper management are not well understood...
  3. ncbi request reprint Telomerase activity in human endometrium
    S Kyo
    Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University, Ishikawa, Japan
    Cancer Res 57:610-4. 1997
    ....
  4. ncbi request reprint How to inhibit telomerase activity for cancer therapy
    Satoru Kyo
    Department of Obstetrics and Gynecology, Kanazawa University, School of Medicine, 13 1, Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Curr Med Chem Anticancer Agents 2:613-26. 2002
    ..This review includes a summary of recent attempts to inhibit telomerase activity in cancer cells and a discussion of how these tools can be applied to cancer therapy, especially in combination with established anti-cancer agents...
  5. doi request reprint Forkhead transcription factor FOXO1 is a direct target of progestin to inhibit endometrial epithelial cell growth
    Satoru Kyo
    Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Clin Cancer Res 17:525-37. 2011
    ....
  6. pmc Significance of immunological detection of human telomerase reverse transcriptase: re-evaluation of expression and localization of human telomerase reverse transcriptase
    Satoru Kyo
    Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 163:859-67. 2003
    ..Further analysis is needed to clarify the biological significance of cytoplasmic hTERT...
  7. doi request reprint Stem cells in endometrium and endometrial cancer: accumulating evidence and unresolved questions
    Satoru Kyo
    Department of Obstetrics and Gynecology, Kanazawa University, Graduate School of Medical Science, Japan
    Cancer Lett 308:123-33. 2011
    ..These studies help us to understand the mechanisms of endometrial regeneration as well as endometrial carcinogenesis and will hopefully help in establishing novel molecular-based cancer therapies targeting stem cells...
  8. ncbi request reprint High Twist expression is involved in infiltrative endometrial cancer and affects patient survival
    Satoru Kyo
    Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Hum Pathol 37:431-8. 2006
    ..Thus, our data implies that high Twist expression is a potential novel prognostic factor for disease survival of endometrial cancer. Furthermore, the present study implicates Twist as a potential therapeutic target for this tumor type...
  9. ncbi request reprint Complex regulatory mechanisms of telomerase activity in normal and cancer cells: how can we apply them for cancer therapy?
    Satoru Kyo
    Department of Obstetrics and Gynecology, Kanazawa University, School of Medicine, Japan
    Oncogene 21:688-97. 2002
    ..This review includes a summary of recent works on telomerase regulation and a discussion of how we can overcome this situation...
  10. ncbi request reprint Telomerase activity in cancer as a diagnostic and therapeutic target
    S Kyo
    Department of Obstetrics and Gynecology, Kanazawa University, School of Medicine, Takaramachi, Ishikawa, Japan
    Histol Histopathol 15:813-24. 2000
    ..Understanding of such mechanisms might provide insight into molecular basis of human carcinogenesis and contributes to the development of novel cancer gene therapy targeting telomerase...
  11. pmc Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT)
    S Kyo
    Department of Obstetrics and Gynecology, Kanazawa University, School of Medicine, 13 1 Takaramachi, Kanazawa, Ishikawa 920 0934, Japan
    Nucleic Acids Res 28:669-77. 2000
    ..These findings suggest that c-Myc and Sp1 cooperatively function as the major determinants of hTERT expression, and that the switching functions of Myc/Max and Mad/Max might also play roles in telomerase regulation...
  12. ncbi request reprint Estrogen activates telomerase
    S Kyo
    Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University, Ishikawa, Japan
    Cancer Res 59:5917-21. 1999
    ..These findings may help elucidate the mechanisms of hormonal control of telomerase activity and aid understanding of the roles of sex steroids in cellular senescence and aging as well as estrogen-induced carcinogenesis...
  13. ncbi request reprint Expression of human telomerase subunits in ovarian malignant, borderline and benign tumors
    S Kyo
    Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University, Ishikawa, Japan
    Int J Cancer 80:804-9. 1999
    ..Up-regulation of hTERT may play a critically important role in the development of ovarian cancers...
  14. ncbi request reprint Human telomerase reverse transcriptase as a critical determinant of telomerase activity in normal and malignant endometrial tissues
    S Kyo
    Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University, Ishikawa, Japan
    Int J Cancer 80:60-3. 1999
    ..Since some normal tissues with high regenerative potential can express hTERT, special attention should be paid to the clinical use of hTERT inhibitors as anti-cancer drugs...
  15. ncbi request reprint Quantitative differences in telomerase activity among malignant, premalignant, and benign ovarian lesions
    S Kyo
    Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University, Japan
    Clin Cancer Res 4:399-405. 1998
    ..Significant levels of telomerase activation frequently occurred in cancer but rarely occurred in premalignant and benign lesions, suggesting that telomerase activation is a critical step in cancer development...
  16. ncbi request reprint Telomerase activity in cervical cancer is quantitatively distinct from that in its precursor lesions
    S Kyo
    Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University, Japan
    Int J Cancer 79:66-70. 1998
    ..Our findings also suggest that stretch PCR assay can distinguish telomerase activity in cancer from that in non-cancerous lesions and may be useful for the differential diagnosis of cancer lesions...
  17. ncbi request reprint Expression of telomerase activity in human chorion
    S Kyo
    Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University, Ishikawa, Japan
    Biochem Biophys Res Commun 241:498-503. 1997
    ..The findings of the present study also appear to support the emerging concept that normal somatic cells with stem cell-like characteristics can express telomerase activity...
  18. doi request reprint Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers
    Satoru Kyo
    Department of Obstetrics and Gynecology, Kanazawa University, Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Cancer Sci 99:1528-38. 2008
    ..This technology can be applied to intraoperative imaging of metastatic lymphnodes. Thus, we found novel tools for cancer diagnostics and therapeutics by utilizing the hTERT promoter...
  19. ncbi request reprint Induction of hTERT expression and phosphorylation by estrogen via Akt cascade in human ovarian cancer cell lines
    Akiko Kimura
    Department of Obstetrics and Gynecology, Osaka University Medical School, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Oncogene 23:4505-15. 2004
    ..Thus, the phosphorylation of Akt is a key event in the induction of telomerase activity by E(2) in human ovarian cancer cells...
  20. ncbi request reprint Diagnostic potential and limitation of imaging cancer cells in cytological samples using telomerase-specific replicative adenovirus
    Yoshiko Maida
    Department of Obstetrics and Gynecology, Kanazawa University, Graduate School of Medical Science, Kanazawa, Ishikawa 920 8641, Japan
    Int J Oncol 34:1549-56. 2009
    ..Thus, OBP-401-based sorting of GFP-positive cells successfully enriched cancer cells, allowing efficient detection of genetic or epigenetic abnormalities in cytological samples...
  21. ncbi request reprint Activation of ERK1/2 occurs independently of KRAS or BRAF status in endometrial cancer and is associated with favorable prognosis
    Yasunari Mizumoto
    Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kanazawa University, 13 1, Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Cancer Sci 98:652-8. 2007
    ..047). These findings suggest that ERK activation occurs in a KRAS- and BRAF-independent manner in endometrial cancer, and is associated with favorable prognosis...
  22. ncbi request reprint Association of mismatch repair deficiency with PTEN frameshift mutations in endometrial cancers and the precursors in a Japanese population
    Taro Kanaya
    Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Japan
    Am J Clin Pathol 124:89-96. 2005
    ..These findings indicate that MLH1 hypermethylation is an early event frequently occurring in hyperplasia without atypia, whereas the PTEN mutation occurs later, mostly in atypical hyperplasia, possibly caused by MLH1 hypermethylation...
  23. doi request reprint Prognostic impact of CD133 expression as a tumor-initiating cell marker in endometrial cancer
    Mitsuhiro Nakamura
    Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920 8641, Japan
    Hum Pathol 41:1516-29. 2010
    ..045). Thus, the present study demonstrates that CD133 is not only a tumor-initiating cell marker but also a critical prognostic marker in endometrial cancer...
  24. ncbi request reprint Tamoxifen regulates human telomerase reverse transcriptase (hTERT) gene expression differently in breast and endometrial cancer cells
    Zhuo Wang
    Department of Obstetrics and Gynecology, Kanazawa University, School of Medicine, 13 1, Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Oncogene 21:3517-24. 2002
    ..Tamoxifen-induced activation of hTERT may be one component of estrogen agonistic function of tamoxifen that is involved in endometrial carcinogenesis induced by this agent...
  25. pmc Successful immortalization of endometrial glandular cells with normal structural and functional characteristics
    Satoru Kyo
    Department of Obstetrics and Gynecology, Kanazawa University, School of Medicine, Kanazawa, Japan
    Am J Pathol 163:2259-69. 2003
    ..Our established cell lines show great promise for investigation of hormone functions, endometrial biology, and endometrial carcinogenesis...
  26. ncbi request reprint 2-5A antisense therapy directed against human telomerase RNA inhibits telomerase activity and induces apoptosis without telomere impairment in cervical cancer cells
    Noriyuki Yatabe
    Department of Obstetrics and Gynecology, Kanazawa University, School of Medicine, 13 1, Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Cancer Gene Ther 9:624-30. 2002
    ....
  27. ncbi request reprint Role of menin in the regulation of telomerase activity in normal and cancer cells
    Manabu Hashimoto
    Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920 8641, Japan
    Int J Oncol 33:333-40. 2008
    ....
  28. ncbi request reprint Human CYP1B1 is regulated by estradiol via estrogen receptor
    Yuki Tsuchiya
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
    Cancer Res 64:3119-25. 2004
    ....
  29. ncbi request reprint Efficient inhibition of human telomerase reverse transcriptase expression by RNA interference sensitizes cancer cells to ionizing radiation and chemotherapy
    Mitsuhiro Nakamura
    Department of Obstetrics and Gynecology, Graduate School of Kanazawa University, Kanazawa, Ishikawa 920 8641, Japan
    Hum Gene Ther 16:859-68. 2005
    ..These findings suggest that an siRNA-based strategy can be applied to the development of novel telomerase inhibitors, the antitumor effects of which may be enhanced in combination with ionizing radiation and chemotherapy...
  30. ncbi request reprint Decreased responsiveness of naturally occurring mutants of human estrogen receptor alpha to estrogens and antiestrogens
    Sayaka Komagata
    Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    J Steroid Biochem Mol Biol 100:79-86. 2006
    ..In conclusion, we found that some of the naturally occurring human ERalpha mutants with amino acid changes may have an altered responsiveness to estrogen and antiestrogens...
  31. ncbi request reprint Frequent hypermethylation of MLH1 promoter in normal endometrium of patients with endometrial cancers
    Taro Kanaya
    Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa, Ishikawa 920 8641, Japan
    Oncogene 22:2352-60. 2003
    ....
  32. doi request reprint Activation of NF-kappaB is a novel target of KRAS-induced endometrial carcinogenesis
    Yasunari Mizumoto
    Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Clin Cancer Res 17:1341-50. 2011
    ..Although the KRAS mutation is one of critical genetic alterations in endometrial carcinogenesis, the downstream targets are not known...
  33. pmc Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT)
    Hirotaka Nishi
    Department of Obstetrics and Gynecology, Tokyo Medical University, Japan
    Mol Cell Biol 24:6076-83. 2004
    ....
  34. ncbi request reprint Pharmacokinetics of paclitaxel in ovarian cancer patients and genetic polymorphisms of CYP2C8, CYP3A4, and MDR1
    Miki Nakajima
    Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    J Clin Pharmacol 45:674-82. 2005
    ..Genotyping of the CYP2C8, CYP3A4, and MDR1 genes might not be essential to predict adverse effects of paclitaxel in Japanese patients, although an allelic variant of MDR1 may functionally affect the pharmacokinetics of its metabolite...
  35. ncbi request reprint Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss
    Noriko Mori
    Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Cancer Sci 98:1881-8. 2007
    ....
  36. ncbi request reprint Direct activation of telomerase by EGF through Ets-mediated transactivation of TERT via MAP kinase signaling pathway
    Yoshiko Maida
    Department of Obstetrics and Gynecology, Kanazawa University, School of Medicine, 13 1, Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Oncogene 21:4071-9. 2002
    ..Our data support the notion that growth factors directly regulate telomerase via specific signal transduction pathways...
  37. ncbi request reprint Raloxifene inhibits estrogen-induced up-regulation of telomerase activity in a human breast cancer cell line
    Jun Kawagoe
    Department of Obstetrics and Gynecology, Yamagata University, School of Medicine, Iidanishi, Yamagata, Japan
    J Biol Chem 278:43363-72. 2003
    ....
  38. ncbi request reprint hTERT-promoter-based tumor-specific expression of MCP-1 effectively sensitizes cervical cancer cells to a low dose of cisplatin
    Mitsuhiro Nakamura
    Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University, 13 1, Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Cancer Gene Ther 11:1-7. 2004
    ..This system may be a novel strategy for chemotherapy combined with immunogene therapy against otherwise intractable cervical cancers...
  39. ncbi request reprint Aberrant expression and mutations of TGF-beta receptor type II gene in endometrial cancer
    Junko Sakaguchi
    Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Gynecol Oncol 98:427-33. 2005
    ..In the present study, we examined aberrant expression and mutation of the gene TGF-beta receptor type II (TbetaRII) in endometrial cancers of endometrioid subtype...
  40. doi request reprint The PRB-dependent FOXO1/IGFBP-1 axis is essential for progestin to inhibit endometrial epithelial growth
    Mitsuhiro Nakamura
    Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Cancer Lett 336:68-75. 2013
    ..The FOXO1/IGFBP-1 axis is essential for PRB-dependent growth inhibition of endometrial epithelial cells, offering a potential therapeutic clue to enhance the progestin effect...
  41. ncbi request reprint WT1 peptide vaccine stabilized intractable ovarian cancer patient for one year: a case report
    Satoshi Dohi
    Department of Obstetrics and Gynecology, Kanazawa University, Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa, 920 8640 Japan
    Anticancer Res 31:2441-5. 2011
    ..However, the immunotherapeutic mechanism of WT1 peptide and immunological escape mechanism for carcinoma cells remain to be elucidated...
  42. ncbi request reprint HIF-1-mediated activation of telomerase in cervical cancer cells
    Noriyuki Yatabe
    1Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, 13 1, Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Oncogene 23:3708-15. 2004
    ..They also suggest the existence of novel mechanisms of telomerase activation in cancers, and have implications for the molecular basis of hypoxia-induced tumor progression and HIF-1-based cancer gene therapy...
  43. doi request reprint Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase
    Wei Mai
    Division of Translational and Clinical Oncology, Cancer Research Institute, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Clin Cancer Res 15:6810-9. 2009
    ..We investigated the expression, activity, and putative pathologic role of GSK3beta in gastrointestinal, pancreatic, and liver cancers...
  44. ncbi request reprint Is the telomerase assay useful for screening of endometrial lesions?
    Yoshiko Maida
    Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Int J Cancer 100:714-8. 2002
    ....
  45. pmc Evidence of the monoclonal composition of human endometrial epithelial glands and mosaic pattern of clonal distribution in luminal epithelium
    Masaaki Tanaka
    Department of Obstetrics and Gynecology, Kanazawa University, School of Medicine, Ishikawa, Japan
    Am J Pathol 163:295-301. 2003
    ..The possible association between area-specific X inactivation of the endometrial surface and the endometrial receptivity of embryo implantation remains to be clarified...
  46. ncbi request reprint Analysis of telomeric single-strand overhang length in human endometrial cancers
    Manabu Hashimoto
    Department of Obstetrics and Gynecology, Graduate School of Kanazawa University, Ishikawa, Japan
    FEBS Lett 579:2959-64. 2005
    ..These findings suggest that erosion of 3'-OH length, rather than overall telomere length, play roles in endometrial carcinogenesis. Furthermore, long 3'-OH may serve as a molecular marker for aggressive phenotype of tumors...
  47. ncbi request reprint WT1 expression correlates with angiogenesis in endometrial cancer tissue
    Satoshi Dohi
    Department of Obstetrics and Gynecology, Kanazawa University, Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa, 920 8640 Japan
    Anticancer Res 30:3187-92. 2010
    ..No direct comparison has been made of the relationship between the expression of Wilms' tumor gene WT1 within tumor cells and angiogenesis in vivo...
  48. ncbi request reprint Analysis of telomerase activity and telomere length in bone and soft tissue tumors
    Tadashi Terasaki
    Department of Orthopedic Surgery, Kanazawa University, School of Medicine, Kanazawa, Ishikawa 920 8641, Japan
    Oncol Rep 11:1307-11. 2004
    ..The present results indicate that telomerase activation is not prevalent in mesenchymal tumors and is not a critical determinant of telomere length, but it may be a prognostic indicator of mesenchymal tumors...
  49. ncbi request reprint Human CYP2A6 is induced by estrogen via estrogen receptor
    Eriko Higashi
    Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 1192, Japan
    Drug Metab Dispos 35:1935-41. 2007
    ..Furthermore, this mechanism can also explain clinical aspects of increased nicotine metabolism under estrogen-rich environments...
  50. doi request reprint Plasma membrane proteomics identifies bone marrow stromal antigen 2 as a potential therapeutic target in endometrial cancer
    Takuhei Yokoyama
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Cancer 132:472-84. 2013
    ..The combination of biotinylation-based enrichment of cell-surface proteins and iTRAQ analysis should be a useful screening method for future discovery of potential therapeutic targets...
  51. ncbi request reprint Correlation between WT1 expression and cell proliferation in endometrial cancer
    Satoshi Dohi
    Department of Obstetrics and Gynecology, Kanazawa University, Graduate School of Medical Science, Kanazawa, Ishikawa, 920 8641 Japan
    Anticancer Res 29:4887-91. 2009
    ..The Wilms' tumor gene WT1 is overexpressed in endometrial cancer. Although recent studies have revealed that WT1 is a new prognostic factor, it remains unclear whether WT1 plays a pathophysiological role including cell proliferation...
  52. doi request reprint Early growth response-1 mediates downregulation of telomerase in cervical cancer
    Osamu Akutagawa
    Department of Obstetrics and Gynecology, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
    Cancer Sci 99:1401-6. 2008
    ..The present study suggests that Egr-1 plays an important regulatory role in the transcriptional activation of hTERT...
  53. doi request reprint Imatinib sensitizes endometrial cancer cells to cisplatin by targeting CD117-positive growth-competent cells
    Xiuzhi Zhang
    Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Cancer Lett 345:106-14. 2014
    ..Targeting of the SCF/CD117 axis by imatinib sensitized endometrial cancer cells to cisplatin, proposing a novel therapeutic strategy for this tumor type. ..
  54. doi request reprint Molecular characterization of CD133+ cancer stem-like cells in endometrial cancer
    Mitsuhiro Nakamura
    Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920 8641, Japan
    Int J Oncol 44:669-77. 2014
    ..These results will be of assistance in the establishment of molecular target therapy to CSCs in endometrial cancer. ..
  55. doi request reprint Bone marrow-derived cells from male donors can compose endometrial glands in female transplant recipients
    Tomomi Ikoma
    Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
    Am J Obstet Gynecol 201:608.e1-8. 2009
    ..To elucidate the origin of endometrial stem cells, we examined the presence of donor-derived cells in endometria from patients who received bone marrow transplantation from male donors...
  56. pmc Novel functional single nucleotide polymorphisms in the latent transforming growth factor-beta binding protein-1L promoter: effect on latent transforming growth factor-beta binding protein-1L expression level and possible prognostic significance in ovaria
    Tomomi Higashi
    Department of Hygiene, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Ishikawa 920 8640, Japan
    J Mol Diagn 8:342-50. 2006
    ..Further studies using a larger number of samples will definitively determine the correlation between LTBP-1 haplotype and clinical behavior of ovarian cancer...
  57. ncbi request reprint [CA72-4 (TAG-72)]
    Yoshiko Maida
    Department of Obstetrics and Gynecology, Kanazawa University, School of Medicine
    Nihon Rinsho 63:672-4. 2005
  58. ncbi request reprint Immunohistochemical detection of WT1 protein in endometrial cancer
    Satoshi Ohno
    Department of Obstetrics and Gynecology, Kanazawa University, Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8640 Japan
    Anticancer Res 29:1691-5. 2009
    ..The Wilms' tumor gene WT1 is overexpressed in various kinds of solid tumors. However, it remains unclear whether WT1 plays a pathophysiological role in endometrial cancer...
  59. doi request reprint Possible involvement of signal transducer and activator of transcription-3 in cell-cell interactions of peritoneal macrophages and endometrial stromal cells in human endometriosis
    Fumiko Itoh
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Fertil Steril 99:1705-13. 2013
    ..To investigate interactions between peritoneal macrophages and endometrial stromal cells (ESCs) involved in the development of endometriosis...
  60. ncbi request reprint Genetic polymorphisms of CYP2C8 in Japanese population
    Miki Nakajima
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Takara machi 13 1, Kanazawa 920 0934, Japan
    Drug Metab Dispos 31:687-90. 2003
    ..Although several SNPs such as CYP2C8*2, CYP2C8*3, CYP2C8*4, and P404A have been reported to reduce the enzymatic activity, pharmacokinetic abnormalities of drugs metabolized by polymorphic CYP2C8 might be rare in Japanese...
  61. doi request reprint Quality of life improvements among cancer patients in remission following the consumption of Agaricus blazei Murill mushroom extract
    Satoshi Ohno
    Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, Japan Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kanazawa University, Japan Department of Clinical Research Medicine, Teikyo University School of Medicine, Japan Electronic address
    Complement Ther Med 21:460-7. 2013
    ..The aim of this preliminary clinical study was to assess if the daily intake of Agaricus blazei Murill (ABM) granulated powder (SSI Co., Ltd., Tokyo, Japan) for 6 months improved the quality of life (QOL) in cancer patients in remission...
  62. ncbi request reprint Combination of caspase transfer using the human telomerase reverse transcriptase promoter and conventional therapies for malignant glioma cells
    Hayato Takeuchi
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 25:57-63. 2004
    ..These results suggest that agents, which induce apoptosis without inhibiting telomerase activity are a promising counterpart to combine with hTERT/rev-caspase-6 therapy for the management of malignant gliomas...
  63. ncbi request reprint Caspase-8 gene therapy using the human telomerase reverse transcriptase promoter for malignant glioma cells
    Tadashi Komata
    The Center for Surgery Research and Department of Neurosurgery, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Hum Gene Ther 13:1015-25. 2002
    ..These results suggest that the telomerase-specific expression of caspase-8 under hTERT-378 promoter is a novel targeting approach for the treatment of telomerase-positive malignant gliomas...
  64. ncbi request reprint Tumor-specific gene therapy for undifferentiated thyroid carcinoma utilizing the telomerase reverse transcriptase promoter
    Teiji Takeda
    Department of Aging Medicine and Geriatrics, Shinshu University, Graduate School, Matsumoto, Nagano 390 8621, Japan
    J Clin Endocrinol Metab 88:3531-8. 2003
    ..These results indicate that the AdhTERTtk/GCV system is a promising therapy for undifferentiated thyroid carcinoma, which is one of the most malignant tumors, without damage to normal tissues...
  65. ncbi request reprint Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma
    Cheng jueng Chen
    Division of General Surgery, Department of Surgery, Tri Service General Hospital, Taipei, Taiwan, China
    World J Gastroenterol 10:638-42. 2004
    ..Few studies have examined the role of hTERT in hepatocarcinogenesis, and the relationship between c-Myc and telomerase in human hepatocellular carcinoma tissue is unknown...
  66. ncbi request reprint Visualization of intrathoracically disseminated solid tumors in mice with optical imaging by telomerase-specific amplification of a transferred green fluorescent protein gene
    Tatsuo Umeoka
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Cancer Res 64:6259-65. 2004
    ..Our results indicate that intratumoral or intrathoracic injection of Ad-GFP in combination with OBP-301 might be a useful diagnostic method that provides a foundation for future clinical application...
  67. ncbi request reprint Bisphenol A from dental polycarbonate crown upregulates the expression of hTERT
    Akiko Takahashi
    Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
    J Biomed Mater Res B Appl Biomater 71:214-21. 2004
    ..In addition, quantitative real-time PCR analysis showed that BPA increased the expression level of hTERT mRNA in MCF7 cells. Herein, it is demonstrated that hTERT is a new target of BPA...
  68. ncbi request reprint [Genetic diagnosis of endometrial cancer]
    Taro Kanaya
    Department of Molecular Reproductive Biology Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science
    Nihon Rinsho 62:295-8. 2004
  69. ncbi request reprint Relief of p53-mediated telomerase suppression by p73
    Wen Hong Toh
    Laboratory of Molecular Carcinogenesis, Division of Cellular and Molecular Research, National Cancer Centre, 11, Hospital Drive, Singapore 169610, Singapore
    J Biol Chem 280:17329-38. 2005
    ..Together, our data indicate a plausible way by which p73, through HDM2, can oppose p53 tumor suppressor function, thereby possibly contributing to tumorigenesis...
  70. ncbi request reprint Enhanced oncolysis by a tropism-modified telomerase-specific replication-selective adenoviral agent OBP-405 ('Telomelysin-RGD')
    Masaki Taki
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Oncogene 24:3130-40. 2005
    ..Our results suggest that fiber-modified replication-competent adenovirus OBP-405 exhibits a broad target range by increasing infection efficiency, an outcome that has important implications for the treatment of human cancers...
  71. pmc Therapeutic efficacy of PUMA for malignant glioma cells regardless of p53 status
    Hideaki Ito
    Department of Neurosurgery, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Gene Ther 16:685-98. 2005
    ..These results indicate that PUMA, which is regulated under a tumor-specific expression system such as the hTERT promoter, may be better than p53 as a therapeutic tool for malignant gliomas...
  72. pmc Function of AP-1 in transcription of the telomerase reverse transcriptase gene (TERT) in human and mouse cells
    Masahiro Takakura
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Mol Cell Biol 25:8037-43. 2005
    ..The species-specific function of AP-1 in TERT expression may in part help explain the difference in telomerase activity between normal human and mouse cells...
  73. ncbi request reprint Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance
    Marta M Alonso
    Department of Neuro Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 97:1589-600. 2005
    ..Several tumor suppressor pathways have been identified as modulators of telomerase function. We examined the functional role of the retinoblastoma-E2F1 pathway in regulating telomerase activity in malignant gliomas...
  74. ncbi request reprint In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus
    Hiroyuki Kishimoto
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Nat Med 12:1213-9. 2006
    ..This technology is adaptable to detect lymph node metastasis in vivo as a preclinical model of surgical navigation...
  75. ncbi request reprint Tumor-specific expression of the RGD-alpha3(IV)NC1 domain suppresses endothelial tube formation and tumor growth in mice
    Toru Miyoshi
    Department of Medicine and Medical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    FASEB J 20:1904-6. 2006
    ..In conclusion, our findings demonstrate that tumor-specific anti-angiogenic gene therapy utilizing RGD-alpha3(IV)NC1 under the hTERT promoter inhibited angiogenesis in tumors, resulting in an antitumor effect...
  76. ncbi request reprint Combination treatment with 1alpha,25-dihydroxyvitamin D3 and 9-cis-retinoic acid directly inhibits human telomerase reverse transcriptase transcription in prostate cancer cells
    Naoya Ikeda
    Department of Urology, Graduate School of Medicine, Yokohama City University, Kanagawa 236 0004, Japan
    Mol Cancer Ther 2:739-46. 2003
    ..The results of the present study provide evidence on the molecular mechanism of the inhibition of cell growth by these agents, and they could be novel therapeutic agents for prostate cancer...
  77. ncbi request reprint Requirement of E7 oncoprotein for viability of HeLa cells
    Akiko Nishimura
    Laboratory of Gene Analysis, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Microbes Infect 8:984-93. 2006
    ..The activation of p53 and consequent accumulation of p21Cip1, which were triggered by the downregulation of E6, appeared not to be essential for the E2-mediated growth arrest...
  78. ncbi request reprint Genistein represses telomerase activity via both transcriptional and posttranslational mechanisms in human prostate cancer cells
    Shankar Jagadeesh
    Department of Cell Biology, Georgetown University Medical Center, Washington, District of Columbia 20057, USA
    Cancer Res 66:2107-15. 2006
    ..These results show for the first time that genistein represses telomerase activity in prostate cancer cells not only by repressing hTERT transcriptional activity via c-Myc but also by posttranslational modification of hTERT via Akt...
  79. ncbi request reprint Enforced expression of a truncated form of Bax-alpha (tBax) driven by human telomerase reverse transcriptase (hTERT) promoter sensitizes tumor cells to chemotherapeutic agents or tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
    Hiroko Toyota
    Department of Immunology and Intractable Immune Disease Research Center, Tokyo Medical University, Shinjuku ku 160 8402, Tokyo, Japan
    Anticancer Res 26:99-105. 2006
    ..In the present study, whether efficient cell death is induced by tBax expression from human telomerase reverse transcriptase (hTERT) promoter, which is highly active in tumor but not normal cells, was examined...
  80. ncbi request reprint Telomerase-specific replication-selective virotherapy for human cancer
    Takeshi Kawashima
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Clin Cancer Res 10:285-92. 2004
    ..We investigated the antitumor effect of the hTERT-specific replication-competent adenovirus on human cancer cells...
  81. ncbi request reprint EWS/ETS fusions activate telomerase in Ewing's tumors
    Akiko Takahashi
    Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
    Cancer Res 63:8338-44. 2003
    ..These findings indicate that EWS/ETS fusion proteins activate human telomerase activity in Ewing's tumors through up-regulation of TERT gene expression, probably as a transcriptional coactivator...
  82. ncbi request reprint Down-regulation of telomerase activity in malignant glioma cells by p27KIP1
    Takao Kanzawa
    Department of Neurosurgery, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Oncol 23:1703-8. 2003
    ..This inhibitory effect was partially induced by interfering with binding sites of the hTERT core promoter for transcription factors Myc and Sp1. These findings identify a novel role for p27KIP1 in down-regulation of telomerase activity...
  83. ncbi request reprint The telomerase reverse transcriptase (hTERT) gene is a direct target of the histone methyltransferase SMYD3
    Cheng Liu
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 67:2626-31. 2007
    ....