Kouji Kuno

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. pmc ADAMTS1 alters blood vessel morphology and TSP1 levels in LNCaP and LNCaP-19 prostate tumors
    Heléne Gustavsson
    Department of Urology, Lundberg Laboratory for Cancer Research, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    BMC Cancer 10:288. 2010
  2. ncbi request reprint ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix
    K Kuno
    Department of Molecular Pharmacology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    J Biol Chem 274:18821-6. 1999
  3. ncbi request reprint ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan
    K Kuno
    Department of Molecular Membrane Biology, Cancer Research Institute, Kanazawa University, Ishikawa, Japan
    FEBS Lett 478:241-5. 2000
  4. ncbi request reprint The Caenorhabditis elegans ADAMTS family gene adt-1 is necessary for morphogenesis of the male copulatory organs
    Kouji Kuno
    Department of Basic and Clinical Oncology, Center for the Development of Molecular Target Drugs, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    J Biol Chem 277:12228-36. 2002
  5. ncbi request reprint The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential
    Kouji Kuno
    Center for the Development of Molecular Target Drugs, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    Biochem Biophys Res Commun 319:1327-33. 2004
  6. ncbi request reprint A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 null mutant mice develop renal lesions mimicking obstructive nephropathy
    Hitoshi Yokoyama
    Division of Blood Purification, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan
    Nephrol Dial Transplant 17:39-41. 2002
  7. ncbi request reprint Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced antiangiogenic factor expression
    Peirong Lu
    Clinical Immunology Key Laboratory of Jiangsu Province, First Affiliated Hospital of Suzhou University, Suzhou, China
    J Immunol 180:4283-91. 2008

Collaborators

  • Kouji Matsushima
  • H Ohno
  • Takashi Wada
  • H Nakamura
  • Heléne Gustavsson
  • Peirong Lu
  • Hitoshi Yokoyama
  • Tajana Tesan
  • Jan Erik Damber
  • Karin Welén
  • Karin Jennbacken
  • Naofumi Mukaida
  • Longbiao Li
  • Xueguang Zhang
  • Yu Wu
  • Ying Yi Li
  • Tomohisa Baba
  • Ken ichi Kobayashi
  • Hiroki Kurihara
  • Takayuki Shindo

Detail Information

Publications7

  1. pmc ADAMTS1 alters blood vessel morphology and TSP1 levels in LNCaP and LNCaP-19 prostate tumors
    Heléne Gustavsson
    Department of Urology, Lundberg Laboratory for Cancer Research, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    BMC Cancer 10:288. 2010
    ..The aim of this study was to investigate the function of ADAMTS1 in prostate tumors...
  2. ncbi request reprint ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix
    K Kuno
    Department of Molecular Pharmacology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    J Biol Chem 274:18821-6. 1999
    ..Consequently, ADAMTS-1 is an active metalloprotease that is associated with the extracellular matrix. This study strongly suggests that ADAMTS-1 may play a role in the inflammatory process through its protease activity...
  3. ncbi request reprint ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan
    K Kuno
    Department of Molecular Membrane Biology, Cancer Research Institute, Kanazawa University, Ishikawa, Japan
    FEBS Lett 478:241-5. 2000
    ..In addition, deletional analysis demonstrated that the C-terminal spacer region of ADAMTS-1 is necessary to degrade aggrecan. These results suggest that ADAMTS-1 may be involved in the turnover of aggrecan in vivo...
  4. ncbi request reprint The Caenorhabditis elegans ADAMTS family gene adt-1 is necessary for morphogenesis of the male copulatory organs
    Kouji Kuno
    Department of Basic and Clinical Oncology, Center for the Development of Molecular Target Drugs, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    J Biol Chem 277:12228-36. 2002
    ..We hypothesize that ADT-1 controls the ray extension process via remodeling of the ECM in the cuticle...
  5. ncbi request reprint The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential
    Kouji Kuno
    Center for the Development of Molecular Target Drugs, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    Biochem Biophys Res Commun 319:1327-33. 2004
    ..Our data suggest that the C-terminal half region of ADAMTS-1 has therapeutic potential as an inhibitor of tumor growth and metastasis...
  6. ncbi request reprint A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 null mutant mice develop renal lesions mimicking obstructive nephropathy
    Hitoshi Yokoyama
    Division of Blood Purification, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan
    Nephrol Dial Transplant 17:39-41. 2002
    ..We studied the biological role of ADAMTS-1 in the kidney...
  7. ncbi request reprint Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced antiangiogenic factor expression
    Peirong Lu
    Clinical Immunology Key Laboratory of Jiangsu Province, First Affiliated Hospital of Suzhou University, Suzhou, China
    J Immunol 180:4283-91. 2008
    ....