D Koya

Summary

Affiliation: Kanazawa Medical University
Country: Japan

Publications

  1. pmc Renal protective effects of resveratrol
    Munehiro Kitada
    Diabetology and Endocrinology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Kahoku, Ishikawa 920 0293, Japan
    Oxid Med Cell Longev 2013:568093. 2013
  2. pmc Sirtuins and renal diseases: relationship with aging and diabetic nephropathy
    Munehiro Kitada
    Diabetology and Endocrinology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Clin Sci (Lond) 124:153-64. 2013
  3. pmc Autophagy as a therapeutic target in diabetic nephropathy
    Yuki Tanaka
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Exp Diabetes Res 2012:628978. 2012
  4. pmc Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty (fa/fa) rats: a model of type 2 diabetes
    Munehiro Kitada
    Division of Diabetes and Endocrinology, Kanazawa Medical University, Kahoku gun, Ishikawa prefecture 920 0293, Japan
    Exp Diabetes Res 2011:908185. 2011
  5. pmc Biology of obesity: lessons from animal models of obesity
    Keizo Kanasaki
    Division of Diabetes and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    J Biomed Biotechnol 2011:197636. 2011
  6. pmc Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway
    Munehiro Kitada
    Division of Diabetes and Endocrinology, Kanazawa Medical University, Kahoku gun, Ishikawa, Japan
    Diabetes 60:634-43. 2011
  7. pmc Low-Frequency Electroacupuncture Improves Insulin Sensitivity in Obese Diabetic Mice through Activation of SIRT1/PGC-1α in Skeletal Muscle
    Fengxia Liang
    Department of Acupuncture and Moxibustion, Hubei University of Chinese Medicine, Wuhan 430061, China
    Evid Based Complement Alternat Med 2011:735297. 2011
  8. pmc Peroxisome proliferator-activated receptors in diabetic nephropathy
    Shinji Kume
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    PPAR Res 2008:879523. 2008
  9. ncbi request reprint Interventions against nutrient-sensing pathways represent an emerging new therapeutic approach for diabetic nephropathy
    Daisuke Koya
    Department of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa, 920 0293, Japan
    Clin Exp Nephrol 18:210-3. 2014
  10. pmc Diabetic angiopathy and angiogenic defects
    Ling Xu
    Division of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa, 920 0293, Japan
    Fibrogenesis Tissue Repair 5:13. 2012

Collaborators

Detail Information

Publications26

  1. pmc Renal protective effects of resveratrol
    Munehiro Kitada
    Diabetology and Endocrinology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Kahoku, Ishikawa 920 0293, Japan
    Oxid Med Cell Longev 2013:568093. 2013
    ..Therefore, resveratrol may be a useful supplemental treatment for preventing renal injury. ..
  2. pmc Sirtuins and renal diseases: relationship with aging and diabetic nephropathy
    Munehiro Kitada
    Diabetology and Endocrinology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Clin Sci (Lond) 124:153-64. 2013
    ..In the present review, we discuss the protective functions of sirtuins and the association of sirtuins with the pathophysiology of renal diseases, including diabetic nephropathy...
  3. pmc Autophagy as a therapeutic target in diabetic nephropathy
    Yuki Tanaka
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Exp Diabetes Res 2012:628978. 2012
    ..We provide a systematic review of autophagy and discuss the therapeutic potential of autophagy in diabetic nephropathy to help future investigations in this field...
  4. pmc Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty (fa/fa) rats: a model of type 2 diabetes
    Munehiro Kitada
    Division of Diabetes and Endocrinology, Kanazawa Medical University, Kahoku gun, Ishikawa prefecture 920 0293, Japan
    Exp Diabetes Res 2011:908185. 2011
    ..This study examined the renoprotective effects of DR in Wistar fatty (fa/fa) rats (WFRs)...
  5. pmc Biology of obesity: lessons from animal models of obesity
    Keizo Kanasaki
    Division of Diabetes and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    J Biomed Biotechnol 2011:197636. 2011
    ..In this paper, we will analyze animal models of obesity and their use in the research of obesity-associated human health conditions and diseases such as diabetes, cancer, and obstructive sleep apnea syndrome...
  6. pmc Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway
    Munehiro Kitada
    Division of Diabetes and Endocrinology, Kanazawa Medical University, Kahoku gun, Ishikawa, Japan
    Diabetes 60:634-43. 2011
    ..This study examined the renoprotective effects of RSV in db/db mice, a model of type 2 diabetes...
  7. pmc Low-Frequency Electroacupuncture Improves Insulin Sensitivity in Obese Diabetic Mice through Activation of SIRT1/PGC-1α in Skeletal Muscle
    Fengxia Liang
    Department of Acupuncture and Moxibustion, Hubei University of Chinese Medicine, Wuhan 430061, China
    Evid Based Complement Alternat Med 2011:735297. 2011
    ..These results indicated that EA offers a beneficial effect on insulin resistance in obese and diabetic db/db mice, at least partly, via stimulation of SIRT1/PGC-1α, thus resulting in improved insulin signal...
  8. pmc Peroxisome proliferator-activated receptors in diabetic nephropathy
    Shinji Kume
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    PPAR Res 2008:879523. 2008
    ..This review summarizes data from clinical and experimental studies regarding the relationship between PPARs and diabetic nephropathy. The therapeutic potential of PPAR agonists in the treatment of diabetic nephropathy is also discussed...
  9. ncbi request reprint Interventions against nutrient-sensing pathways represent an emerging new therapeutic approach for diabetic nephropathy
    Daisuke Koya
    Department of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa, 920 0293, Japan
    Clin Exp Nephrol 18:210-3. 2014
    ..However, its role in diabetic nephropathy has not been fully known. Here, we will discuss the role of autophagy and its involvement in the pathogenesis of diabetic nephropathy. ..
  10. pmc Diabetic angiopathy and angiogenic defects
    Ling Xu
    Division of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa, 920 0293, Japan
    Fibrogenesis Tissue Repair 5:13. 2012
    ..Additionally, we discuss glucose metabolism defects that are associated with abnormal angiogenesis in atypical diabetic complications such as cancer...
  11. ncbi request reprint Statin use in patients with diabetes and kidney disease: the Japanese experience
    Daisuke Koya
    Division of Diabetology and Endocrinology, Kanazawa Medical University, Japan
    J Atheroscler Thromb 20:407-24. 2013
    ..This review summarizes evidence from studies in Western and Japanese populations to highlight the CV and renal benefits of lipid-lowering agents in CKD patients, including those with diabetes...
  12. ncbi request reprint Sirtuins as possible drug targets in type 2 diabetes
    Munehiro Kitada
    Division of Diabetology and Endocrinology, Kanazawa Medical University, Kahoku gun, Ishikawa prefecture 920 0293, Japan
    Curr Drug Targets 14:622-36. 2013
    ..In this review, we summarize the current understanding of the biological functions of SIRT1, SIRT3 and SIRT6 in metabolism and discuss their potential role as therapeutic targets in T2DM...
  13. pmc Elevation of the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline: a blood pressure-independent beneficial effect of angiotensin I-converting enzyme inhibitors
    Megumi Kanasaki
    Division of Diabetes and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Fibrogenesis Tissue Repair 4:25. 2011
    ....
  14. pmc Long-term effect of modification of dietary protein intake on the progression of diabetic nephropathy: a randomised controlled trial
    D Koya
    Kanazawa Medical University, Uchinadacho, Kahokugun, Ishikawa, Japan
    Diabetologia 52:2037-45. 2009
    ..There is currently insufficient evidence to recommend a low-protein diet for type 2 diabetic patients with diabetic nephropathy. We assessed whether a low-protein diet could prevent the progression of diabetic nephropathy...
  15. ncbi request reprint Predictive impact of elevated serum level of IL-18 for early renal dysfunction in type 2 diabetes: an observational follow-up study
    S Araki
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, 520 2192, Japan
    Diabetologia 50:867-73. 2007
    ..We investigated whether serum levels of IL-18, a proinflammatory cytokine, were a predictor of early renal dysfunction...
  16. ncbi request reprint Endothelin-1 induces cyclooxygenase-2 expression via nuclear factor of activated T-cell transcription factor in glomerular mesangial cells
    T Sugimoto
    The Third Department of Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga, 520-2192 Japan
    J Am Soc Nephrol 12:1359-68. 2001
    ..These results will contribute to evaluation of the precise roles of NFAT in glomerular functions and the CsA-induced nephrotoxicity...
  17. ncbi request reprint Dinucleotide repeat polymorphism of matrix metalloproteinase-9 gene is associated with diabetic nephropathy
    S Maeda
    Third Department of Medicine, Shiga University of Medical Science, Otsu, Japan
    Kidney Int 60:1428-34. 2001
    ....
  18. ncbi request reprint Enhancement of glomerular heme oxygenase-1 expression in diabetic rats
    K Hayashi
    The Third Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Diabetes Res Clin Pract 52:85-96. 2001
    ..In conclusion, these results provide the first evidence that among antioxidant enzymes HO-1 expression is preferentially increased in diabetic glomeruli...
  19. ncbi request reprint Cellular mechanisms in the development and progression of diabetic nephropathy: activation of the DAG-PKC-ERK pathway
    M Haneda
    Third Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Am J Kidney Dis 38:S178-81. 2001
    ..These results confirmed the importance of the activation of the DAG-PKC-ERK pathway in the development of glomerular dysfunction in diabetes...
  20. ncbi request reprint Glucocorticoid-induced diabetes mellitus: prevalence and risk factors in primary renal diseases
    T Uzu
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Nephron Clin Pract 105:c54-7. 2007
    ..We therefore examined the prevalence and risk factors of glucocorticoid-induced diabetes mellitus (DM) in primary renal diseases...
  21. ncbi request reprint Immunohistochemical characterization of glomerular PDGF B-chain and PDGF beta-receptor expression in diabetic rats
    H Nakagawa
    Third Department of Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga, Japan
    Diabetes Res Clin Pract 48:87-98. 2000
    ..Our results suggest that the activation of the PDGF system in glomerular cells might play an important role in the development of early glomerular lesion in diabetes...
  22. ncbi request reprint Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes
    D Koya
    Third Department of Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
    FASEB J 14:439-47. 2000
    ....
  23. doi request reprint Acupuncture: is it effective for treatment of insulin resistance?
    F Liang
    Department of Endocrinology and Metabolism, Kanazawa Medical University, Ishikawa, Japan
    Diabetes Obes Metab 12:555-69. 2010
    ..In addition, acupuncture has the potential to improve insulin sensitivity. The evidence has revealed the mechanisms responsible for the beneficial effects of acupuncture, though further investigations are warranted...
  24. ncbi request reprint SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications
    Shinji Kume
    Department of Medicine, Shiga University of Medical Science, Otsu, Japan
    Endocr Metab Immune Disord Drug Targets 10:16-24. 2010
    ..This review summarizes current understanding of the biological functions of SIRT1, and discusses its potential as a pharmacological target for fighting metabolic and vascular diseases...