Junji Koizumi

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi request reprint Effect of pravastatin-induced LDL-cholesterol reduction on coronary heart disease and cerebrovascular disease in Japanese: Hokuriku lipid coronary heart disease study-pravastatin atherosclerosis trial (Holicos-PAT)
    Junji Koizumi
    School of Medicine, Kanazawa University, Kanazawa, Japan
    J Atheroscler Thromb 9:251-9. 2002
  2. ncbi request reprint Risk evaluation of coronary heart disease and cerebrovascular disease by the Japan Atherosclerosis Society Guidelines 2002 using the cohort of the Holicos-PAT study
    Junji Koizumi
    Department of Internal Medicine, School of Medicine, Kanazawa University, Ishikawa, Japan
    J Atheroscler Thromb 12:48-52. 2005
  3. ncbi request reprint Type III hyperlipoproteinemia exaggerated by Sheehan's syndrome with advanced systemic atherosclerosis: a 28-year clinical course
    Masa aki Kawashiri
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Disease, Kanazawa, Japan
    Circ J 69:746-51. 2005
  4. doi request reprint Molecular genetic epidemiology of homozygous familial hypercholesterolemia in the Hokuriku district of Japan
    Hiroshi Mabuchi
    Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Atherosclerosis 214:404-7. 2011
  5. ncbi request reprint Marked aortic valve stenosis progression after receiving long-term aggressive cholesterol-lowering therapy using low-density lipoprotein apheresis in a patient with familial hypercholesterolemia
    Masayuki Tsuchida
    Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Circ J 73:963-6. 2009
  6. ncbi request reprint High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia
    Atsushi Nohara
    Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8641, Japan
    Arterioscler Thromb Vasc Biol 27:923-8. 2007
  7. ncbi request reprint Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients
    Hiroshi Mabuchi
    Dept of Internal Medicine and Molecular Genetics of Cardiovascular Disorders, Div of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Takara machi 13 1, Kanazawa, Ishikawa 920 8641, Japan
    J Atheroscler Thromb 12:111-9. 2005
  8. ncbi request reprint ATP-binding cassette transporter G8 M429V polymorphism as a novel genetic marker of higher cholesterol absorption in hypercholesterolaemic Japanese subjects
    Kenji Miwa
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiology, Graduate School of Medical Science, Kanazawa University, Japan
    Clin Sci (Lond) 109:183-8. 2005
  9. doi request reprint Novel mutations of cholesteryl ester transfer protein (CETP) gene in Japanese hyperalphalipoproteinemic subjects
    Rumiko Ohtani
    Department of Laboratory Sciences, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kodatsuno, Japan
    Clin Chim Acta 413:537-43. 2012
  10. ncbi request reprint Long-term course of lipoprotein lipase (LPL) deficiency due to homozygous LPL(Arita) in a patient with recurrent pancreatitis, retained glucose tolerance, and atherosclerosis
    Masa aki Kawashiri
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Disease, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    J Clin Endocrinol Metab 90:6541-4. 2005

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Effect of pravastatin-induced LDL-cholesterol reduction on coronary heart disease and cerebrovascular disease in Japanese: Hokuriku lipid coronary heart disease study-pravastatin atherosclerosis trial (Holicos-PAT)
    Junji Koizumi
    School of Medicine, Kanazawa University, Kanazawa, Japan
    J Atheroscler Thromb 9:251-9. 2002
    ....
  2. ncbi request reprint Risk evaluation of coronary heart disease and cerebrovascular disease by the Japan Atherosclerosis Society Guidelines 2002 using the cohort of the Holicos-PAT study
    Junji Koizumi
    Department of Internal Medicine, School of Medicine, Kanazawa University, Ishikawa, Japan
    J Atheroscler Thromb 12:48-52. 2005
    ..However, the risk evaluation by the JAS guideline categories may underestimate the risk in men and overestimate it in women...
  3. ncbi request reprint Type III hyperlipoproteinemia exaggerated by Sheehan's syndrome with advanced systemic atherosclerosis: a 28-year clinical course
    Masa aki Kawashiri
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Disease, Kanazawa, Japan
    Circ J 69:746-51. 2005
    ..These findings suggest that the continuous elevation of intermediate-density lipoprotein cholesterol for a long period contributed to the development of the atherosclerotic lesions...
  4. doi request reprint Molecular genetic epidemiology of homozygous familial hypercholesterolemia in the Hokuriku district of Japan
    Hiroshi Mabuchi
    Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Atherosclerosis 214:404-7. 2011
    ..e. LDL-receptor (LDLR), PCSK9 and apolipoprotein B (ApoB) gene. We evaluated the usefulness of DNA analysis for the diagnosis of homozygous FH (homo-FH), and studied the frequency of FH in the Hokuriku district of Japan...
  5. ncbi request reprint Marked aortic valve stenosis progression after receiving long-term aggressive cholesterol-lowering therapy using low-density lipoprotein apheresis in a patient with familial hypercholesterolemia
    Masayuki Tsuchida
    Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Circ J 73:963-6. 2009
    ..These findings suggest that careful attention to the progression of aortic valve stenosis is needed for extreme hypercholesterolemic patients even under optimal cholesterol-lowering therapy for the secondary prevention of CAD...
  6. ncbi request reprint High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia
    Atsushi Nohara
    Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8641, Japan
    Arterioscler Thromb Vasc Biol 27:923-8. 2007
    ..Because several nuclear receptors play pivotal roles in lipid metabolism, we tested the hypothesis that genetic variants of nuclear receptors contribute to FCHL...
  7. ncbi request reprint Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients
    Hiroshi Mabuchi
    Dept of Internal Medicine and Molecular Genetics of Cardiovascular Disorders, Div of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Takara machi 13 1, Kanazawa, Ishikawa 920 8641, Japan
    J Atheroscler Thromb 12:111-9. 2005
    ..627, p = 0.0165). As atorvastatin reduces serum ubiquinol-10 as well as serum cholesterol levels in all patients, it is imperative that physicians are forewarned about the risks associated with ubiquinol-10 depletion...
  8. ncbi request reprint ATP-binding cassette transporter G8 M429V polymorphism as a novel genetic marker of higher cholesterol absorption in hypercholesterolaemic Japanese subjects
    Kenji Miwa
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiology, Graduate School of Medical Science, Kanazawa University, Japan
    Clin Sci (Lond) 109:183-8. 2005
    ..Future studies should investigate whether these findings have implications for the optimal cholesterol-lowering drug treatment in hypercholesterolaemic patients...
  9. doi request reprint Novel mutations of cholesteryl ester transfer protein (CETP) gene in Japanese hyperalphalipoproteinemic subjects
    Rumiko Ohtani
    Department of Laboratory Sciences, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kodatsuno, Japan
    Clin Chim Acta 413:537-43. 2012
    ..The half of hyperalphalipoproteinemia (HALP) in Japan is caused by CETP gene mutations. Other than two prevalent mutations (D442G and Intron 14 splicing donor site +1G>A), some rare CETP mutations are found in Japanese HALP subjects...
  10. ncbi request reprint Long-term course of lipoprotein lipase (LPL) deficiency due to homozygous LPL(Arita) in a patient with recurrent pancreatitis, retained glucose tolerance, and atherosclerosis
    Masa aki Kawashiri
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Disease, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    J Clin Endocrinol Metab 90:6541-4. 2005
    ..Patients with LPL deficiency suffer from the frequent recurrence of acute pancreatitis, but the underlying mechanisms are not fully understood...
  11. ncbi request reprint Cholesterol-years score is associated with development of senile degenerative aortic stenosis in heterozygous familial hypercholesterolemia
    Tsuyoshi Nozue
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Japan
    J Atheroscler Thromb 13:323-8. 2006
    ..These results suggest that physicians should be aware that AS needs attention in older patients with heterozygous FH, especially women who have been diagnosed late in life and those who have been inadequately treated...
  12. ncbi request reprint Association of coronary artery ectasia with plasma insulin levels in Japanese men of heterozygous familial hypercholesterolemia with the low-density lipoprotein receptor gene mutation K790X
    Yuko Murase
    Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa, Ishikawa, 920 8640, Japan
    Clin Chim Acta 355:33-9. 2005
    ..Hyperinsulinemia is widely believed to be an important coronary risk factor. We investigated the effect of plasma insulin levels on the development of coronary ectasia in Japanese men with heterozygous familial hypercholesterolemia (FH)...
  13. doi request reprint Cholesterol efflux from J774 macrophages and Fu5AH hepatoma cells to serum is preserved in CETP-deficient patients
    Kenji Miwa
    Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Clin Chim Acta 402:19-24. 2009
    ..The role of CETP in the development of atherosclerosis is debatable, and few data exist regarding the total impact of CETP inhibition on cholesterol efflux...
  14. ncbi request reprint Identification of a novel missense mutation in the sterol 27-hydroxylase gene in two Japanese patients with cerebrotendinous xanthomatosis
    Tsuyoshi Nozue
    Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, Yokohama, Japan
    Intern Med 49:1127-31. 2010
    ..To our knowledge, this is the first report in which the Arg104Gln mutation is identified in CTX patients. Probably case 2 would be a compound heterozygote for Arg441Trp in exon 8 and a mutation that was not identified...
  15. doi request reprint Impacts of visceral adipose tissue and subcutaneous adipose tissue on metabolic risk factors in middle-aged Japanese
    Rie Oka
    Department of Internal Medicine, Hokuriku Central Hospital, Toyama, Japan
    Obesity (Silver Spring) 18:153-60. 2010
    ..VAT showed dominant impacts on triglyceride concentrations in both genders and on HDL-cholesterol in women, while SAT also had an independent association with blood pressure...
  16. ncbi request reprint Electrocardiographic events and cholesterol reduction with pravastatin in patients with hypercholesterolemia: the Hokuriku Lipid Coronary Heart Disease Study-Pravastatin Atherosclerosis Trial
    Masami Shimizu
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8640, Japan
    Int J Cardiol 99:395-401. 2005
    ..Cholesterol lowering therapy may offset the development of coronary atherosclerosis, and the resulting reduction in coronary ischemia may be observed in the electrocardiogram (ECG)...
  17. ncbi request reprint Detailed analysis of serum lipids and lipoproteins from Japanese type III hyperlipoproteinemia with apolipoprotein E2/2 phenotype
    Yasuhiro Todo
    Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    Clin Chim Acta 348:35-40. 2004
    ..To clarify a detailed profile of serum lipids, lipoproteins and apolipoproteins (apo) in type III hyperlipoproteinemia (HLP) with apolipoprotein E (apo E) phenotype 2/2...
  18. ncbi request reprint [Concept, definition, and reference for diagnosis of hypolipidemia]
    Shoji Katsuda
    Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University
    Nihon Rinsho 65:564-7. 2007
  19. ncbi request reprint Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study
    Hiroshi Mabuchi
    Department of Lipidology, Kanazawa University Graduate School of Medical Science, Takara machi 13 1, Kanazawa 920 8641, Japan
    Atherosclerosis 195:e182-9. 2007
    ..These changes in plasma CoQ10 levels showed no relation to the changes in serum AST, ALT and CK levels. Further studies are needed, however, for the evaluation of CoQ10 supplementation in statin therapy...
  20. ncbi request reprint Serum lipoprotein lipase mass: clinical significance of its measurement
    Junji Kobayashi
    Department of Lipidology, Kanazawa University Graduate School of Medical Science Takara machi 13 1, Kanazawa 920 8640, and Department of General Medicine, Kanazawa University Hospital, Japan
    Clin Chim Acta 378:7-12. 2007
    ..Taken together, we suggest that pre-heparin LPL mass in plasma or sera provide us with useful and important information on the development of metabolic disorders leading to atherosclerotic disease...
  21. ncbi request reprint Efficacy of colestimide coadministered with atorvastatin in japanese patients with heterozygous familial hypercholesterolemia (FH)
    Masa aki Kawashiri
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Disease, Graduate School of Kanazawa University
    Circ J 69:515-20. 2005
    ..Moreover, colestimide has excellent patient compliance because it is available in tablet form...
  22. ncbi request reprint Cutoff point separating affected and unaffected familial hypercholesterolemic patients validated by LDL-receptor gene mutants
    Hiroshi Mabuchi
    Department of Internal Medicine and Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    J Atheroscler Thromb 12:35-40. 2005
    ..0058 for total cholesterol, and 0.9852 +/- 0.0043 for LDL-cholesterol. In conclusion, we define total cholesterol and LDL-cholesterol levels of 225 and 160 mg/dl, respectively, as cutoff points of normal subjects and FH patients...
  23. ncbi request reprint An LMNA variant is associated with dyslipidemia and insulin resistance in the Japanese
    Yuko Murase
    Second Department of Internal Medicine, Kanazawa University, Ishikawa, Japan
    Metabolism 51:1017-21. 2002
    ..These results suggest the LMNA 1908C/T single nucleotide polymorphism (SNP) is not associated with the prevalence of type 2 diabetes, although it may be a factor predisposing to insulin resistance and dyslipidemia in some Japanese...
  24. ncbi request reprint Long-term treatment with pitavastatin (NK-104), a new HMG-CoA reductase inhibitor, of patients with heterozygous familial hypercholesterolemia
    Yoshihiro Noji
    Molecular Genetics of Cardiovascular Disorders The Second Department of Internal Medicine, Vascular Medicine, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Atherosclerosis 163:157-64. 2002
    ..As for the safety of pitavastatin, adverse reactions were observed in one case (4%) of subjective and objective symptoms. The effects of pitavastatin on TC and LDL-C were stable during long treatment of patients with heterozygous FH...
  25. ncbi request reprint Effects of an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase on serum lipoproteins and ubiquinone-10 levels in patients with familial hypercholesterolemia. 1981
    Hiroshi Mabuchi
    Atheroscler Suppl 5:51-5. 2004
  26. ncbi request reprint [Clinical trials of cholesterol lowering for the secondary prevention of coronary heart disease]
    Junji Koizumi
    Department of General Medicine, Kanazawa University Hospital
    Nihon Rinsho 65:252-6. 2007