Research Topics
Species | Ryoichi KizuSummaryAffiliation: Kanazawa University Country: Japan Publications
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Detail Information
Publications
A new luciferase reporter gene assay for the detection of androgenic and antiandrogenic effects based on a human prostate specific antigen promoter and PC3/AR human prostate cancer cellsRyoichi Kizu
Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 0934, Japan
Anal Sci 20:55-9. 2004..We developed the first assay system, in which the expression of luciferase was driven by the promoter of a prostate-specific antigen gene, a typical human androgen-regulated gene...- A role of aryl hydrocarbon receptor in the antiandrogenic effects of polycyclic aromatic hydrocarbons in LNCaP human prostate carcinoma cellsRyoichi Kizu
Graduate School of Natural Science and Technology, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
Arch Toxicol 77:335-43. 2003..These results suggest that AhR can stimulate AP-1 expression resulting in inhibition of the binding of AR to ARE in the transcription regulatory region of target genes such as PSA... - Antiandrogenic activity of extracts of diesel exhaust particles emitted from diesel-engine truck under different engine loads and speedsKazumasa Okamura
Graduate School of Natural Science and Technology, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-0934, Japan
Toxicology 195:243-54. 2004..In conclusion, the antiandrogenic effects of DEPE samples were enhanced by a higher engine load which resulted in DEPC samples with elevated AhR agonistic and AR antagonistic activities... - Antiandrogenic activities of diesel exhaust particle extracts in PC3/AR human prostate carcinoma cellsRyoichi Kizu
Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 0934, Japan
Toxicol Sci 76:299-309. 2003.... - Activation of 5-lipoxygenase and NF-kappa B in the action of acenaphthenequinone by modulation of oxidative stressSang Woon Chung
Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
Toxicol Sci 101:152-8. 2008..Thus, based on our findings, we propose that AcQ-induced damage is likely due to increased RS generation and NF-kappa B activity through 5-LO activation... - Evaluation of estrogenic activities of hydroxylated polycyclic aromatic hydrocarbons in cigarette smoke condensateMakiko Kamiya
Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
Food Chem Toxicol 43:1017-27. 2005..This is a first study to identify estrogenic hydroxylated PAHs in cigarette smoke condensate. The present findings points out the necessity for detailed investigation of exposure to aerosols containing apparently estrogenic compounds... - Quantification of polycyclic aromatic hydrocarbons (PAHs) in human hair by HPLC with fluorescence detection: a biological monitoring method to evaluate the exposure to PAHsAkira Toriba
Graduate School of Natural Science and Technology, Kanazawa University, 13 1, Takara machi, Kanazawa, Ishikawa 920 0934, Japan
Biomed Chromatogr 17:126-32. 2003..The analysis of PAHs in human hair should be useful as a new biomarker to evaluate the exposure to PAHs... - Identification of estrogenic/anti-estrogenic compounds in diesel exhaust particulate extractKeiko Noguchi
Graduate School of Natural Science and Technology Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma machi, Kanazawa, Japan
Biomed Chromatogr 21:1135-42. 2007..This is the first study to identify 2,6-dimethyl-4-nitrophenol in DEPE and the first study to show that it is an estrogenic compound. In the N fraction, 1-hydroxypyrene was also identified by LC-MS/MS as an anti-estrogenic compound... - Method for determining monohydroxybenzo[a]pyrene isomers using column-switching high-performance liquid chromatographyAkira Toriba
Graduate School of Natural Science and Technology, Kanazawa University, 13-1, Takara-machi, Kanazawa City, Ishikawa 920-0934, Japan
Anal Biochem 312:14-22. 2003..2% for 1-OHP, respectively. In 11 kinds of isomers, only 3-OHBaP was detected in the human urine. Urinary concentration of 3-OHBaP was quantified at 0.5 ng/g creatinine concentration and the 3-OHBaP/1-OHP ratio was approximately 1/130... - Decreased responsiveness of naturally occurring mutants of human estrogen receptor alpha to estrogens and antiestrogensSayaka Komagata
Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
J Steroid Biochem Mol Biol 100:79-86. 2006..In conclusion, we found that some of the naturally occurring human ERalpha mutants with amino acid changes may have an altered responsiveness to estrogen and antiestrogens... - Direct-acting mutagenicity of extracts of coal burning-derived particulates and contribution of nitropolycyclic aromatic hydrocarbonsRina Taga
Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
Mutat Res 581:91-5. 2005..3. Among the NPAHs examined, 3-nitrobenzanthrone made the largest mutagenic contribution. This is the first report of detection of 3-nitrobenzanthrone in coal burning-derived particulates... - Hair analysis of nicotine and cotinine for evaluating tobacco smoke exposure by liquid chromatography-mass spectrometryThaneeya Chetiyanukornkul
Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan
Biomed Chromatogr 18:655-61. 2004..In both cases, the method provided good selectivity, accuracy and precision... - Quantification of 2-hydroxyfluorene in human urine by column-switching high performance liquid chromatography with fluorescence detectionAkira Toriba
Graduate School of Natural Science and Technology, Kanazawa University, 13 1, Takara machi, Kanazawa, Ishikawa 920 0934, Japan
Analyst 128:605-10. 2003..01). Thus, the data suggest that urinary 2-OHF might be a sensitive and specific biological marker for the assessment of the exposure to polycyclic aromatic hydrocarbons... - Improvement of an automatic HPLC system for nitropolycyclic aromatic hydrocarbons: removal of an interfering peak and increase in the number of analytesNing Tang
Graduate School of Natural Science and Technology, Kanazawa University, 13-1, Takara-machi, Kanazawa 920-0934, Japan
Anal Sci 19:249-53. 2003..3 to 1.8 mL/min... - An environmental quinoid polycyclic aromatic hydrocarbon, acenaphthenequinone, modulates cyclooxygenase-2 expression through reactive oxygen species generation and nuclear factor kappa B activation in A549 cellsSang Woon Chung
Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 1192, Japan
Toxicol Sci 95:348-55. 2007..These results provide that AcQ might play an important role in human lung inflammatory diseases as an air pollutant... - Girolline, an antitumor compound isolated from a sponge, induces G2/M cell cycle arrest and accumulation of polyubiquitinated p53Sachiko Tsukamoto
Faculty of Pharmaceutical Sciences, Kanazawa University, Japan
Biol Pharm Bull 27:699-701. 2004..Based on the above findings, we propose that girolline affects the step of recruitment of polyubiquitinated p53 to the proteasome... - [Physical properties and metal elutions of the thirteen molten slags produced from incinerated ash]Jun Kobayashi
Department of Health Science, Faculty of Medicine, Kanazawa University, Japan
Yakugaku Zasshi 124:621-5. 2004..There was little elution of toxic metals in the elution test when water was used as a solvent. On the other hand, when acid and alkali were used, the elution of toxic metals tended to become greater... - Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differencesMasashi Iwanari
Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Takara-machi 13-1, Kanazawa 920-0934, Japan
Arch Toxicol 76:287-98. 2002..Furthermore, the cell-specific induction of the CYP1 family was not related to the expression levels of aryl hydrocarbon receptor, aryl hydrocarbon nuclear translocator, or estrogen receptors alpha and beta... - Damage to and recovery of coastlines polluted with C-heavy oil spilled from the NakhodkaKazuichi Hayakawa
Graduate School of Natural Science and Technology, Kanazawa University, Kakama machi, Kanazawa 920 1192, Japan
Water Res 40:981-9. 2006..These results suggest that the coastlines in Ishikawa and Fukui Prefectures that were polluted with C-heavy oil recovered in 3 years... - Perturbation of spermatogenesis by androgen antagonists directly injected into seminiferous tubules of live miceKaz Nagaosa
Graduate School of Natural Science and Technology and Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920 1192, Japan
Reproduction 133:21-7. 2007..We propose that the method adopted in this study is a novel assay system to identify potential testicular toxicants... - Metal elution and content of fused slags produced from incinerated ashJun Kobayashi
Department of Health Science, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa 920 0942, Japan
Chem Pharm Bull (Tokyo) 52:1378-81. 2004.... 
Stress-activated mitogen-activated protein kinases c-Jun NH2-terminal kinase and p38 target Cdc25B for degradationSanae Uchida
Division of Life Science, Graduate School of Natural Science and Technology, Venture Business Laboratory, Center for Innovation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
Cancer Res 69:6438-44. 2009..These results highlight the importance of a novel JNK/p38-Cdc25B axis for a nongenotoxic stress-induced cell cycle checkpoint...- Determination of 1-hydroxypyrene in human urine by high-performance liquid chromatography with fluorescence detection using a deuterated internal standardThaneeya Chetiyanukornkul
Graduate School of Natural Science and Technology, Kanazawa University, Ishikawa, Japan
J Chromatogr A 961:107-12. 2002..Urine sample treatment involved enzymatic hydrolysis followed by solid-phase extraction using Sep-Pak C18 cartridges. The proposed method was used to determine urinary 1-OHP in smokers and non-smokers... - Homologue and isomer distribution of dioxins observed in water samples collected from Kahokugata Lagoon and inflowing rivers, JapanHitoshi Kakimoto
Ishikawa Prefectural Institute of Public Health and Environmental Science, 1 11 Taiyogaoka, Kanazawa 920 1154, Japan
Water Res 40:1929-40. 2006..The dyeing discharge was found to make a contribution only in the water samples collected near the plant and the seasonal variation of the contribution might depend on the flow rate of the river... - Preparation of antitumor oxaliplatin/cisplatin docking dinuclear platinum complexMasahede Noji
Suzuka University of Medical Science, 1001 1 Kishioka cho, Suzuka, Mie 510 0293, Japan
Biomed Pharmacother 59:224-9. 2005..The antitumor effect against L1210/CDDP was very high, showing collateral sensitivity, being similar to that of oxaliplatin, and against L1210/DACH it showed no cross-resistance... - Amino acids C-terminal to the 14-3-3 binding motif in CDC25B affect the efficiency of 14-3-3 bindingSanae Uchida
Division of Life Science, Graduate School of Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192
J Biochem (Tokyo) 139:761-9. 2006.... - Simultaneous detection of monohydroxybenzo[a]pyrene positional isomers by reversed-phase liquid chromatography coupled to electrospray ionization mass spectrometryHideki Sasaki
Nihon Waters K K, 3 12, Kitashingawa 1 chome, Shinagawa ku, Tokyo 140 0001, Japan
Biomed Chromatogr 16:432-6. 2002..This method identified 1-, 3- and 9-OH BaPs as the major metabolites, and 2- (and/or 8-) and 12-OH BaPs as the minor metabolites in the incubation mixture... - Rapid effects of diesel exhaust particulate extracts on intracellular signaling in human endothelial cellsWasana K Sumanasekera
Department of Biochemistry and Molecular Biology and The Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
Toxicol Lett 174:61-73. 2007..These data are the first characterization of rapid effects of DEPE in human EC and may indicate mechanisms for diesel exhaust in vascular function... - Enantioseparation of vinclozolin by gamma-cyclodextrin-modified micellar electrokinetic chromatographyShuji Kodama
Toyama Institute of Health, 17 1 Nakataikoyama, Kosugi Machi, Toyama 939 0363, Japan
J Agric Food Chem 50:1312-7. 2002..The anti-androgenic activity of (+)-vinclozolin tended to be stronger than that of (-)-vinclozolin, suggesting the possibility that vinclozolin can act as an enantioselective anti-androgen...