Ryoichi Kizu

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi request reprint A new luciferase reporter gene assay for the detection of androgenic and antiandrogenic effects based on a human prostate specific antigen promoter and PC3/AR human prostate cancer cells
    Ryoichi Kizu
    Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 0934, Japan
    Anal Sci 20:55-9. 2004
  2. ncbi request reprint A role of aryl hydrocarbon receptor in the antiandrogenic effects of polycyclic aromatic hydrocarbons in LNCaP human prostate carcinoma cells
    Ryoichi Kizu
    Graduate School of Natural Science and Technology, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Arch Toxicol 77:335-43. 2003
  3. ncbi request reprint Antiandrogenic activity of extracts of diesel exhaust particles emitted from diesel-engine truck under different engine loads and speeds
    Kazumasa Okamura
    Graduate School of Natural Science and Technology, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    Toxicology 195:243-54. 2004
  4. ncbi request reprint Antiandrogenic activities of diesel exhaust particle extracts in PC3/AR human prostate carcinoma cells
    Ryoichi Kizu
    Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 0934, Japan
    Toxicol Sci 76:299-309. 2003
  5. ncbi request reprint Activation of 5-lipoxygenase and NF-kappa B in the action of acenaphthenequinone by modulation of oxidative stress
    Sang Woon Chung
    Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Toxicol Sci 101:152-8. 2008
  6. ncbi request reprint Evaluation of estrogenic activities of hydroxylated polycyclic aromatic hydrocarbons in cigarette smoke condensate
    Makiko Kamiya
    Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Food Chem Toxicol 43:1017-27. 2005
  7. ncbi request reprint Quantification of polycyclic aromatic hydrocarbons (PAHs) in human hair by HPLC with fluorescence detection: a biological monitoring method to evaluate the exposure to PAHs
    Akira Toriba
    Graduate School of Natural Science and Technology, Kanazawa University, 13 1, Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    Biomed Chromatogr 17:126-32. 2003
  8. ncbi request reprint Identification of estrogenic/anti-estrogenic compounds in diesel exhaust particulate extract
    Keiko Noguchi
    Graduate School of Natural Science and Technology Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma machi, Kanazawa, Japan
    Biomed Chromatogr 21:1135-42. 2007
  9. ncbi request reprint Method for determining monohydroxybenzo[a]pyrene isomers using column-switching high-performance liquid chromatography
    Akira Toriba
    Graduate School of Natural Science and Technology, Kanazawa University, 13 1, Takara machi, Kanazawa City, Ishikawa 920 0934, Japan
    Anal Biochem 312:14-22. 2003
  10. ncbi request reprint Decreased responsiveness of naturally occurring mutants of human estrogen receptor alpha to estrogens and antiestrogens
    Sayaka Komagata
    Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    J Steroid Biochem Mol Biol 100:79-86. 2006

Collaborators

Detail Information

Publications29

  1. ncbi request reprint A new luciferase reporter gene assay for the detection of androgenic and antiandrogenic effects based on a human prostate specific antigen promoter and PC3/AR human prostate cancer cells
    Ryoichi Kizu
    Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 0934, Japan
    Anal Sci 20:55-9. 2004
    ..We developed the first assay system, in which the expression of luciferase was driven by the promoter of a prostate-specific antigen gene, a typical human androgen-regulated gene...
  2. ncbi request reprint A role of aryl hydrocarbon receptor in the antiandrogenic effects of polycyclic aromatic hydrocarbons in LNCaP human prostate carcinoma cells
    Ryoichi Kizu
    Graduate School of Natural Science and Technology, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Arch Toxicol 77:335-43. 2003
    ..These results suggest that AhR can stimulate AP-1 expression resulting in inhibition of the binding of AR to ARE in the transcription regulatory region of target genes such as PSA...
  3. ncbi request reprint Antiandrogenic activity of extracts of diesel exhaust particles emitted from diesel-engine truck under different engine loads and speeds
    Kazumasa Okamura
    Graduate School of Natural Science and Technology, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    Toxicology 195:243-54. 2004
    ..In conclusion, the antiandrogenic effects of DEPE samples were enhanced by a higher engine load which resulted in DEPC samples with elevated AhR agonistic and AR antagonistic activities...
  4. ncbi request reprint Antiandrogenic activities of diesel exhaust particle extracts in PC3/AR human prostate carcinoma cells
    Ryoichi Kizu
    Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 0934, Japan
    Toxicol Sci 76:299-309. 2003
    ....
  5. ncbi request reprint Activation of 5-lipoxygenase and NF-kappa B in the action of acenaphthenequinone by modulation of oxidative stress
    Sang Woon Chung
    Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Toxicol Sci 101:152-8. 2008
    ..Thus, based on our findings, we propose that AcQ-induced damage is likely due to increased RS generation and NF-kappa B activity through 5-LO activation...
  6. ncbi request reprint Evaluation of estrogenic activities of hydroxylated polycyclic aromatic hydrocarbons in cigarette smoke condensate
    Makiko Kamiya
    Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Food Chem Toxicol 43:1017-27. 2005
    ..This is a first study to identify estrogenic hydroxylated PAHs in cigarette smoke condensate. The present findings points out the necessity for detailed investigation of exposure to aerosols containing apparently estrogenic compounds...
  7. ncbi request reprint Quantification of polycyclic aromatic hydrocarbons (PAHs) in human hair by HPLC with fluorescence detection: a biological monitoring method to evaluate the exposure to PAHs
    Akira Toriba
    Graduate School of Natural Science and Technology, Kanazawa University, 13 1, Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    Biomed Chromatogr 17:126-32. 2003
    ..The analysis of PAHs in human hair should be useful as a new biomarker to evaluate the exposure to PAHs...
  8. ncbi request reprint Identification of estrogenic/anti-estrogenic compounds in diesel exhaust particulate extract
    Keiko Noguchi
    Graduate School of Natural Science and Technology Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma machi, Kanazawa, Japan
    Biomed Chromatogr 21:1135-42. 2007
    ..This is the first study to identify 2,6-dimethyl-4-nitrophenol in DEPE and the first study to show that it is an estrogenic compound. In the N fraction, 1-hydroxypyrene was also identified by LC-MS/MS as an anti-estrogenic compound...
  9. ncbi request reprint Method for determining monohydroxybenzo[a]pyrene isomers using column-switching high-performance liquid chromatography
    Akira Toriba
    Graduate School of Natural Science and Technology, Kanazawa University, 13 1, Takara machi, Kanazawa City, Ishikawa 920 0934, Japan
    Anal Biochem 312:14-22. 2003
    ..2% for 1-OHP, respectively. In 11 kinds of isomers, only 3-OHBaP was detected in the human urine. Urinary concentration of 3-OHBaP was quantified at 0.5 ng/g creatinine concentration and the 3-OHBaP/1-OHP ratio was approximately 1/130...
  10. ncbi request reprint Decreased responsiveness of naturally occurring mutants of human estrogen receptor alpha to estrogens and antiestrogens
    Sayaka Komagata
    Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    J Steroid Biochem Mol Biol 100:79-86. 2006
    ..In conclusion, we found that some of the naturally occurring human ERalpha mutants with amino acid changes may have an altered responsiveness to estrogen and antiestrogens...
  11. ncbi request reprint Direct-acting mutagenicity of extracts of coal burning-derived particulates and contribution of nitropolycyclic aromatic hydrocarbons
    Rina Taga
    Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Mutat Res 581:91-5. 2005
    ..3. Among the NPAHs examined, 3-nitrobenzanthrone made the largest mutagenic contribution. This is the first report of detection of 3-nitrobenzanthrone in coal burning-derived particulates...
  12. ncbi request reprint Hair analysis of nicotine and cotinine for evaluating tobacco smoke exposure by liquid chromatography-mass spectrometry
    Thaneeya Chetiyanukornkul
    Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa, Ishikawa 920 1192, Japan
    Biomed Chromatogr 18:655-61. 2004
    ..In both cases, the method provided good selectivity, accuracy and precision...
  13. ncbi request reprint Quantification of 2-hydroxyfluorene in human urine by column-switching high performance liquid chromatography with fluorescence detection
    Akira Toriba
    Graduate School of Natural Science and Technology, Kanazawa University, 13 1, Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    Analyst 128:605-10. 2003
    ..01). Thus, the data suggest that urinary 2-OHF might be a sensitive and specific biological marker for the assessment of the exposure to polycyclic aromatic hydrocarbons...
  14. ncbi request reprint Improvement of an automatic HPLC system for nitropolycyclic aromatic hydrocarbons: removal of an interfering peak and increase in the number of analytes
    Ning Tang
    Graduate School of Natural Science and Technology, Kanazawa University, 13 1, Takara machi, Kanazawa 920 0934, Japan
    Anal Sci 19:249-53. 2003
    ..3 to 1.8 mL/min...
  15. ncbi request reprint An environmental quinoid polycyclic aromatic hydrocarbon, acenaphthenequinone, modulates cyclooxygenase-2 expression through reactive oxygen species generation and nuclear factor kappa B activation in A549 cells
    Sang Woon Chung
    Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 1192, Japan
    Toxicol Sci 95:348-55. 2007
    ..These results provide that AcQ might play an important role in human lung inflammatory diseases as an air pollutant...
  16. ncbi request reprint Girolline, an antitumor compound isolated from a sponge, induces G2/M cell cycle arrest and accumulation of polyubiquitinated p53
    Sachiko Tsukamoto
    Faculty of Pharmaceutical Sciences, Kanazawa University, Japan
    Biol Pharm Bull 27:699-701. 2004
    ..Based on the above findings, we propose that girolline affects the step of recruitment of polyubiquitinated p53 to the proteasome...
  17. ncbi request reprint [Physical properties and metal elutions of the thirteen molten slags produced from incinerated ash]
    Jun Kobayashi
    Department of Health Science, Faculty of Medicine, Kanazawa University, Japan
    Yakugaku Zasshi 124:621-5. 2004
    ..There was little elution of toxic metals in the elution test when water was used as a solvent. On the other hand, when acid and alkali were used, the elution of toxic metals tended to become greater...
  18. ncbi request reprint Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences
    Masashi Iwanari
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Takara machi 13 1, Kanazawa 920 0934, Japan
    Arch Toxicol 76:287-98. 2002
    ..Furthermore, the cell-specific induction of the CYP1 family was not related to the expression levels of aryl hydrocarbon receptor, aryl hydrocarbon nuclear translocator, or estrogen receptors alpha and beta...
  19. ncbi request reprint Damage to and recovery of coastlines polluted with C-heavy oil spilled from the Nakhodka
    Kazuichi Hayakawa
    Graduate School of Natural Science and Technology, Kanazawa University, Kakama machi, Kanazawa 920 1192, Japan
    Water Res 40:981-9. 2006
    ..These results suggest that the coastlines in Ishikawa and Fukui Prefectures that were polluted with C-heavy oil recovered in 3 years...
  20. ncbi request reprint Perturbation of spermatogenesis by androgen antagonists directly injected into seminiferous tubules of live mice
    Kaz Nagaosa
    Graduate School of Natural Science and Technology and Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920 1192, Japan
    Reproduction 133:21-7. 2007
    ..We propose that the method adopted in this study is a novel assay system to identify potential testicular toxicants...
  21. ncbi request reprint Metal elution and content of fused slags produced from incinerated ash
    Jun Kobayashi
    Department of Health Science, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa 920 0942, Japan
    Chem Pharm Bull (Tokyo) 52:1378-81. 2004
    ....
  22. doi request reprint Stress-activated mitogen-activated protein kinases c-Jun NH2-terminal kinase and p38 target Cdc25B for degradation
    Sanae Uchida
    Division of Life Science, Graduate School of Natural Science and Technology, Venture Business Laboratory, Center for Innovation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Res 69:6438-44. 2009
    ..These results highlight the importance of a novel JNK/p38-Cdc25B axis for a nongenotoxic stress-induced cell cycle checkpoint...
  23. ncbi request reprint Determination of 1-hydroxypyrene in human urine by high-performance liquid chromatography with fluorescence detection using a deuterated internal standard
    Thaneeya Chetiyanukornkul
    Graduate School of Natural Science and Technology, Kanazawa University, Ishikawa, Japan
    J Chromatogr A 961:107-12. 2002
    ..Urine sample treatment involved enzymatic hydrolysis followed by solid-phase extraction using Sep-Pak C18 cartridges. The proposed method was used to determine urinary 1-OHP in smokers and non-smokers...
  24. ncbi request reprint Homologue and isomer distribution of dioxins observed in water samples collected from Kahokugata Lagoon and inflowing rivers, Japan
    Hitoshi Kakimoto
    Ishikawa Prefectural Institute of Public Health and Environmental Science, 1 11 Taiyogaoka, Kanazawa 920 1154, Japan
    Water Res 40:1929-40. 2006
    ..The dyeing discharge was found to make a contribution only in the water samples collected near the plant and the seasonal variation of the contribution might depend on the flow rate of the river...
  25. ncbi request reprint Preparation of antitumor oxaliplatin/cisplatin docking dinuclear platinum complex
    Masahede Noji
    Suzuka University of Medical Science, 1001 1 Kishioka cho, Suzuka, Mie 510 0293, Japan
    Biomed Pharmacother 59:224-9. 2005
    ..The antitumor effect against L1210/CDDP was very high, showing collateral sensitivity, being similar to that of oxaliplatin, and against L1210/DACH it showed no cross-resistance...
  26. ncbi request reprint Amino acids C-terminal to the 14-3-3 binding motif in CDC25B affect the efficiency of 14-3-3 binding
    Sanae Uchida
    Division of Life Science, Graduate School of Science and Technology, Kanazawa University, Kakuma machi, Kanazawa, Ishikawa 920 1192
    J Biochem 139:761-9. 2006
    ....
  27. ncbi request reprint Simultaneous detection of monohydroxybenzo[a]pyrene positional isomers by reversed-phase liquid chromatography coupled to electrospray ionization mass spectrometry
    Hideki Sasaki
    Nihon Waters K K, 3 12, Kitashingawa 1 chome, Shinagawa ku, Tokyo 140 0001, Japan
    Biomed Chromatogr 16:432-6. 2002
    ..This method identified 1-, 3- and 9-OH BaPs as the major metabolites, and 2- (and/or 8-) and 12-OH BaPs as the minor metabolites in the incubation mixture...
  28. ncbi request reprint Rapid effects of diesel exhaust particulate extracts on intracellular signaling in human endothelial cells
    Wasana K Sumanasekera
    Department of Biochemistry and Molecular Biology and The Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Toxicol Lett 174:61-73. 2007
    ..These data are the first characterization of rapid effects of DEPE in human EC and may indicate mechanisms for diesel exhaust in vascular function...
  29. ncbi request reprint Enantioseparation of vinclozolin by gamma-cyclodextrin-modified micellar electrokinetic chromatography
    Shuji Kodama
    Toyama Institute of Health, 17 1 Nakataikoyama, Kosugi Machi, Toyama 939 0363, Japan
    J Agric Food Chem 50:1312-7. 2002
    ..The anti-androgenic activity of (+)-vinclozolin tended to be stronger than that of (-)-vinclozolin, suggesting the possibility that vinclozolin can act as an enantioselective anti-androgen...