Y Kasahara

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi Cell type specific infection of Epstein-Barr virus (EBV) in EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection
    Yoshihito Kasahara
    Department of Pediatrics, Angiogenesis and Vascular Development, Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Crit Rev Oncol Hematol 44:283-94. 2002
  2. ncbi Differential cellular targets of Epstein-Barr virus (EBV) infection between acute EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection
    Y Kasahara
    Department of Pediatrics, Angiogenesis and Vascular Development, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan
    Blood 98:1882-8. 2001
  3. ncbi Anti-angiogenic therapy and radioimmunotherapy in colon cancer xenografts
    S Kinuya
    Department of Nuclear Medicine, Kanazawa University School of Medicine, Ishikawa, Japan
    Eur J Nucl Med 28:1306-12. 2001
  4. ncbi Clonotypic analysis of T cell reconstitution after haematopoietic stem cell transplantation (HSCT) in patients with severe combined immunodeficiency
    H Okamoto
    Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Clin Exp Immunol 148:450-60. 2007
  5. ncbi Tubular injury as a cardinal pathologic feature in human heme oxygenase-1 deficiency
    K Ohta
    Department of Pediatrics and Division of Blood Purification, School of Medicine, Kanazawa University, Japan
    Am J Kidney Dis 35:863-70. 2000
  6. ncbi Selective expansion of CD16highCCR2- subpopulation of circulating monocytes with preferential production of haem oxygenase (HO)-1 in response to acute inflammation
    K Mizuno
    Department of Pediatrics, Angiogenesis and Vascular Development, Graduate School of Medicine, Faculty of Medicine, Kanazawa University, Kanazawa, Japan
    Clin Exp Immunol 142:461-70. 2005
  7. ncbi Oligoclonal expansion of circulating and tissue-infiltrating CD8+ T cells with killer/effector phenotypes in juvenile dermatomyositis syndrome
    K Mizuno
    Department of Paediatrics, School of Health Sciences, Faculty of Medicine, University of Kanazawa, Kanazawa, Japan
    Clin Exp Immunol 137:187-94. 2004
  8. ncbi Analysis of MPO-ANCA subtypes in a patient with propylthiouracil-induced vasculitis with multiple complications
    K Ohta
    Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan
    Clin Nephrol 68:315-21. 2007
  9. ncbi Cytoprotective role of heme oxygenase (HO)-1 in human kidney with various renal diseases
    K Morimoto
    Department of Pediatrics, School of Medicine, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan
    Kidney Int 60:1858-66. 2001
  10. ncbi Structural evidence of genomic exon-deletion mediated by Alu-Alu recombination in a human case with heme oxygenase-1 deficiency
    Y Saikawa
    Department of Pediatrics, School of Medicine, Faculty of Medicine, Kanazawa University, Japan
    Hum Mutat 16:178-9. 2000

Collaborators

Detail Information

Publications31

  1. ncbi Cell type specific infection of Epstein-Barr virus (EBV) in EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection
    Yoshihito Kasahara
    Department of Pediatrics, Angiogenesis and Vascular Development, Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Crit Rev Oncol Hematol 44:283-94. 2002
    ....
  2. ncbi Differential cellular targets of Epstein-Barr virus (EBV) infection between acute EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection
    Y Kasahara
    Department of Pediatrics, Angiogenesis and Vascular Development, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan
    Blood 98:1882-8. 2001
    ....
  3. ncbi Anti-angiogenic therapy and radioimmunotherapy in colon cancer xenografts
    S Kinuya
    Department of Nuclear Medicine, Kanazawa University School of Medicine, Ishikawa, Japan
    Eur J Nucl Med 28:1306-12. 2001
    ..Anti-angiogenic therapy may prolong the dormancy of microscopic metastases while RIT may exterminate this population of cells. Therefore, the combined treatment may improve the therapeutic outcome of patients with disseminated cancer...
  4. ncbi Clonotypic analysis of T cell reconstitution after haematopoietic stem cell transplantation (HSCT) in patients with severe combined immunodeficiency
    H Okamoto
    Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Clin Exp Immunol 148:450-60. 2007
    ..These results indicate that early expansion of TCR diversity may reflect transient expansion of pre-existing mature T cells from the donor blood, independent of de novo T cell maturation through the thymus...
  5. ncbi Tubular injury as a cardinal pathologic feature in human heme oxygenase-1 deficiency
    K Ohta
    Department of Pediatrics and Division of Blood Purification, School of Medicine, Kanazawa University, Japan
    Am J Kidney Dis 35:863-70. 2000
    ..This is the first report to show that HO-1 has critical roles in vivo in protecting renal tubuli, in addition to vascular endothelium, from oxidative injury...
  6. ncbi Selective expansion of CD16highCCR2- subpopulation of circulating monocytes with preferential production of haem oxygenase (HO)-1 in response to acute inflammation
    K Mizuno
    Department of Pediatrics, Angiogenesis and Vascular Development, Graduate School of Medicine, Faculty of Medicine, Kanazawa University, Kanazawa, Japan
    Clin Exp Immunol 142:461-70. 2005
    ..More importantly, they may represent a monocyte subpopulation with a unique functional role to regulate inflammation by producing HO-1 in steady state in vivo...
  7. ncbi Oligoclonal expansion of circulating and tissue-infiltrating CD8+ T cells with killer/effector phenotypes in juvenile dermatomyositis syndrome
    K Mizuno
    Department of Paediatrics, School of Health Sciences, Faculty of Medicine, University of Kanazawa, Kanazawa, Japan
    Clin Exp Immunol 137:187-94. 2004
    ....
  8. ncbi Analysis of MPO-ANCA subtypes in a patient with propylthiouracil-induced vasculitis with multiple complications
    K Ohta
    Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan
    Clin Nephrol 68:315-21. 2007
    ..We report a 16 year-old girl with propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-positive glomerulonephritis combined with Henoch-Schönlein purpura nephritis (HSPN) and antiphospholipid syndrome (APS)...
  9. ncbi Cytoprotective role of heme oxygenase (HO)-1 in human kidney with various renal diseases
    K Morimoto
    Department of Pediatrics, School of Medicine, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan
    Kidney Int 60:1858-66. 2001
    ..It is suggested that renal tubular epithelia are more susceptible to oxidative stress due to the lack of this critical enzyme in HO-1 deficiency...
  10. ncbi Structural evidence of genomic exon-deletion mediated by Alu-Alu recombination in a human case with heme oxygenase-1 deficiency
    Y Saikawa
    Department of Pediatrics, School of Medicine, Faculty of Medicine, Kanazawa University, Japan
    Hum Mutat 16:178-9. 2000
    ..This study presents the initial characterization of the HO-1 gene defect causing a human case of HO-1 deficiency and provides the molecular basis for understanding this genetic disease...
  11. ncbi Characterization of immune function and analysis of RAG gene mutations in Omenn syndrome and related disorders
    T Wada
    Department of Paediatrics, Kanazawa University, Japan
    Clin Exp Immunol 119:148-55. 2000
    ..Variations of Omenn syndrome, or related disorders, may represent a different type of immunodeficiency, distinct from abnormalities in lymphoid-specific recombinase activity...
  12. ncbi Increasing prevalence of ampicillin- resistant, non-beta-lactamase-producing strains of Haemophilus influenzae in children in Japan
    H Seki
    Department of Nursing, School of Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa, Japan
    Chemotherapy 45:15-21. 1999
    ..influenzae isolates in this study. Results indicate that BLNAR strains have emerged among children with respiratory tract infections in Japan...
  13. ncbi Immunoblot analysis of cellular expression of Bcl-2 family proteins, Bcl-2, Bax, Bcl-X and Mcl-1, in human peripheral blood and lymphoid tissues
    K Ohta
    Department of Pediatrics, School of Medicine, Kanazawa University, Ishikawa, Japan
    Int Immunol 7:1817-25. 1995
    ..The results support the notion that a balance of expression of Bcl-2 family proteins may regulate the life and death of hematolymphoid cells at different stages of cell differentiation and activation...
  14. ncbi Treatment with low-dose angiotensin-converting enzyme inhibitor (ACEI) plus angiotensin II receptor blocker (ARB) in pediatric patients with IgA nephropathy
    Y Yang
    Department of Pediatrics, Graduate School of Medical Science, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
    Clin Nephrol 64:35-40. 2005
    ....
  15. ncbi Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
    A Yachie
    Department of Laboratory Sciences, School of Health Sciences, Kanazawa University, Japan
    J Clin Invest 103:129-35. 1999
    ..This study presents not only the first human case of HO-1 deficiency but may also provide clues to the key roles played by this important enzyme in vivo...
  16. ncbi Methylxanthine sensitization of human colon cancer cells to 186Re-labeled monoclonal antibody
    S Kinuya
    Departments of Nuclear Medicine and Pediatrics, Kanazawa University School of Medicine, Kanazawa, Japan
    J Nucl Med 42:596-600. 2001
    ..8% +/- 8.12%) or 2 mmol/L CAF (26.9% +/- 6.21%). CONCLUSION: Cellular modulation of the cell cycle with PTX and CAF radiosensitized LS180 colon cancer cells exposed to 186Re radiation...
  17. ncbi [Survey of vaccination for physically-handicapped and epileptic children]
    M Sakakibara
    Department of Pediatrics, Ishikawa Seishi Gakuen Hospital, Kanazawa, Ishikawa
    No To Hattatsu 33:21-6. 2001
    ..Although a half of our patients had epilepsy, they were safely vaccinated with few side effects...
  18. ncbi Skin infiltration of CD56(bright) CD16(-) natural killer cells in a case of X-SCID with Omenn syndrome-like manifestations
    Fumie Shibata
    Department of Pediatrics, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Eur J Haematol 79:81-5. 2007
    ..This may be the first human case to demonstrate that close cell-to-cell contact between DC and NK cells provides an effective alternative pathway for NK cell differentiation/activation in vivo...
  19. ncbi Rituximab therapy for Epstein-Barr virus-related chronic hepatitis following living donor kidney transplantation
    Kazuhide Ohta
    Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Ishikawa 920 8641, Japan
    Am J Kidney Dis 48:986-9. 2006
    ..The present case illustrates the significance of early diagnosis, monitoring of viral load, and vigorous management of EBV-related disorders associated with organ transplantation...
  20. ncbi Oligoclonal expansion of T lymphocytes with multiple second-site mutations leads to Omenn syndrome in a patient with RAG1-deficient severe combined immunodeficiency
    Taizo Wada
    Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Blood 106:2099-101. 2005
    ..These findings suggest that his revertant T-cell mosaicism is responsible for OS phenotype switched from T-B- SCID...
  21. ncbi Epstein-Barr virus-associated T-/natural killer cell lymphoproliferative diseases
    Akihiro Yachie
    Department of Laboratory Sciences, School of Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa, Japan
    Semin Hematol 40:124-32. 2003
    ..Target cell specificity, defects in host immune responses, and strain differences of EBV may account for ectopic EBV infections and for the unique clinical presentations characteristic of each illness...
  22. ncbi Heme oxygenase-1 production by peripheral blood monocytes during acute inflammatory illnesses of children
    Akihiro Yachie
    Department of Laboratory Sciences, School of Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa 920 0942, Japan
    Exp Biol Med (Maywood) 228:550-6. 2003
    ....
  23. ncbi Detection of T lymphocytes with a second-site mutation in skin lesions of atypical X-linked severe combined immunodeficiency mimicking Omenn syndrome
    Taizo Wada
    Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Japan
    Blood 112:1872-5. 2008
    ..These findings suggest that the clinical spectrum of XSCID is quite broad and includes atypical cases mimicking Omenn syndrome, and highlight the importance of revertant mosaicism as a possible cause for variable phenotypic expression...
  24. ncbi [Diversity of virus-infected cells in EB-virus related diseases]
    Yoshihito Kasahara
    Nihon Rinsho Meneki Gakkai Kaishi 26:54-65. 2003
  25. ncbi Identification of DKC1 gene mutations in Japanese patients with X-linked dyskeratosis congenita
    Hirokazu Kanegane
    Department of Paediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Br J Haematol 129:432-4. 2005
    ..Such genetic analysis is useful for the definite diagnosis and genetic counselling of patients...
  26. ncbi [Role of T cells in the pathogenesis of type I diabetes mellitus: structure analysis of complementarity determining region 3 of circulating T cells]
    Masahiro Sakumai
    Department of Clinical Laboratory, Kanazawa Medical University Hospital, Kahoku gun, Ishikawa 920 0293
    Rinsho Byori 55:112-9. 2007
    ..Reductions of CDR3 sizes were frequently seen among CD8+ T cells from patients whose onset was within 10 years. These results suggested that selective expansion of CD8+ T cell clones play roles in the pathogenesis of type 1 DM...
  27. ncbi Somatic revertant mosaicism in a patient with leukocyte adhesion deficiency type 1
    Yumi Tone
    Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Japan
    Blood 109:1182-4. 2007
    ..These findings suggest that spontaneous in vivo reversion was responsible for the somatic mosaicism in our patient...
  28. ncbi Selective protection of renal tubular epithelial cells by heme oxygenase (HO)-1 during stress-induced injury
    Yonghong Yang
    Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan
    Kidney Int 64:1302-9. 2003
    ..These facts suggest that the renal tubuli are dependent on intrinsic HO-1 production for their survival under oxidative stresses...
  29. ncbi Diagnostic value of serum EBV-DNA quantification and antibody to viral capsid antigen in nasopharyngeal carcinoma patients
    Satoru Kondo
    Division of Otolaryngology, Graduate School of Medicine, Cancer Research Institute, Kanazawa University, Ishikawa, Kanazawa 920-8640, Japan
    Cancer Sci 95:508-13. 2004
    ..ROC analysis again revealed a higher diagnostic value of EBV-DNA than EBV-VCA. These results suggest EBV-DNA is a more reliable tumor marker than EBV-VCA in both high-incidence and low-incidence areas of NPC...
  30. ncbi Paradoxical enhancement of oxidative cell injury by overexpression of heme oxygenase-1 in an anchorage-dependent cell ECV304
    Keiko Maruhashi
    Department of Pediatrics, Angiogenesis and Vascular Development, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    J Cell Biochem 93:552-62. 2004
    ..However, HO-1 reduces the oxidative cell injury and protects the endothelial cells, if its expression is appropriately controlled. Copyright 2004 Wiley-Liss, Inc...
  31. ncbi Granulysin in human serum as a marker of cell-mediated immunity
    Kazuyuki Ogawa
    R and D Center, BML, 1361 1 Matoba, Kawagoe, Saitama 350 1101, Japan
    Eur J Immunol 33:1925-33. 2003
    ....