Osamu Hori

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. pmc ATF6alpha promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson's disease
    Koji Hashida
    Department of Neuroanatomy, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan
    PLoS ONE 7:e47950. 2012
  2. pmc Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2
    Anika E Wagner
    Institute of Human Nutrition and Food Science, Christian Albrechts University of Kiel, Germany
    BMC Complement Altern Med 11:1. 2011
  3. ncbi request reprint A carbazole derivative protects cells against endoplasmic reticulum (ER) stress and glutathione depletion
    Hikari Miura
    Department of Neuroanatomy, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa, Ishikawa, Japan
    J Pharmacol Sci 108:164-71. 2008
  4. ncbi request reprint Does ORP150/HSP12A protect dopaminergic neurons against MPTP/MPP(+)-induced neurotoxicity?
    Yasuko Kitao
    Department of Neuroanatomy Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Antioxid Redox Signal 9:589-95. 2007
  5. ncbi request reprint Vaticanol B, a resveratrol tetramer, regulates endoplasmic reticulum stress and inflammation
    Yoshiyuki Tabata
    Dept of Neuroanatomy, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa City, Ishikawa, 920 8640, Japan
    Am J Physiol Cell Physiol 293:C411-8. 2007
  6. ncbi request reprint A dibenzoylmethane derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum stress
    Katsura Takano
    Department of Neuroanatomy, Kanazawa University Graduate School of Medical Science, Kanazawa City, Ishikawa, Japan
    Am J Physiol Cell Physiol 293:C1884-94. 2007
  7. ncbi request reprint Gene therapy for prostate cancer using the cytosine deaminase/uracil phosphoribosyltransferase suicide system
    Tohru Miyagi
    Department of Urology, Kanazawa University School of Medicine, Kanazawa, Japan
    J Gene Med 5:30-7. 2003
  8. ncbi request reprint Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation
    Yasuko Kitao
    Department of Neuroanatomy, Kanazawa University Medical School, 13 1, Takara machi, Kanazawa City, 920 8640 Ishikawa, Japan
    Hum Mol Genet 16:50-60. 2007
  9. doi request reprint Deletion of Herp facilitates degradation of cytosolic proteins
    Hikari Miura
    Department of Neuroanatomy, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920 8640, Japan
    Genes Cells 15:843-53. 2010
  10. ncbi request reprint A rat model of human FENIB (familial encephalopathy with neuroserpin inclusion bodies)
    Katsura Takano
    Department of Neuroanatomy, Kanazawa University Medical School, Ishikawa, Japan
    Biochem Biophys Res Commun 346:1040-7. 2006

Collaborators

Detail Information

Publications23

  1. pmc ATF6alpha promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson's disease
    Koji Hashida
    Department of Neuroanatomy, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan
    PLoS ONE 7:e47950. 2012
    ..These results suggest that the UPR is activated in a mouse model of chronic MPTP/P injection, and contributes to the survival of nigrostriatal dopaminergic neurons, in part, through activated astrocytes...
  2. pmc Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2
    Anika E Wagner
    Institute of Human Nutrition and Food Science, Christian Albrechts University of Kiel, Germany
    BMC Complement Altern Med 11:1. 2011
    ..However, little is known about the underlying mechanisms for potential health benefits of resveratrol and its interactions with ascorbic acid...
  3. ncbi request reprint A carbazole derivative protects cells against endoplasmic reticulum (ER) stress and glutathione depletion
    Hikari Miura
    Department of Neuroanatomy, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa, Ishikawa, Japan
    J Pharmacol Sci 108:164-71. 2008
    ..These results suggest that 16-14 may protect cells against different stresses via the maintenance of intracellular Ca(2+) homeostasis. [Supplementary Fig. 1: available only at http://dx.doi.org/10.1254/jphs.08136FP]...
  4. ncbi request reprint Does ORP150/HSP12A protect dopaminergic neurons against MPTP/MPP(+)-induced neurotoxicity?
    Yasuko Kitao
    Department of Neuroanatomy Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Antioxid Redox Signal 9:589-95. 2007
    ..Our observations led to the hypothesis that ORP150 protects against MPTP/MPP(+)-induced neurotoxicity, and indicate the importance of the ER environment in maintaining the nigrostriatal pathways...
  5. ncbi request reprint Vaticanol B, a resveratrol tetramer, regulates endoplasmic reticulum stress and inflammation
    Yoshiyuki Tabata
    Dept of Neuroanatomy, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa City, Ishikawa, 920 8640, Japan
    Am J Physiol Cell Physiol 293:C411-8. 2007
    ..These results suggest that vaticanol B is a novel anti-inflammatory agent that improves the ER environment by reducing the protein load on the ER and by maintaining the membrane integrity of the ER...
  6. ncbi request reprint A dibenzoylmethane derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum stress
    Katsura Takano
    Department of Neuroanatomy, Kanazawa University Graduate School of Medical Science, Kanazawa City, Ishikawa, Japan
    Am J Physiol Cell Physiol 293:C1884-94. 2007
    ..These results suggest that 14-26 is an antioxidant that protects dopaminergic neurons against both oxidative stress and ER stress and could be a therapeutic candidate for the treatment of PD...
  7. ncbi request reprint Gene therapy for prostate cancer using the cytosine deaminase/uracil phosphoribosyltransferase suicide system
    Tohru Miyagi
    Department of Urology, Kanazawa University School of Medicine, Kanazawa, Japan
    J Gene Med 5:30-7. 2003
    ..This study demonstrates the effectiveness of transduction of the UPRT gene in addition to CD/5-FC cancer suicide gene therapy...
  8. ncbi request reprint Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation
    Yasuko Kitao
    Department of Neuroanatomy, Kanazawa University Medical School, 13 1, Takara machi, Kanazawa City, 920 8640 Ishikawa, Japan
    Hum Mol Genet 16:50-60. 2007
    ..These data suggest a model in which ER- and dopamine-related stress are major contributors to decreased viability of dopaminergic neurons in a setting relevant to Parkinson's disease...
  9. doi request reprint Deletion of Herp facilitates degradation of cytosolic proteins
    Hikari Miura
    Department of Neuroanatomy, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920 8640, Japan
    Genes Cells 15:843-53. 2010
    ..These results suggest that ERAD molecule Herp may delay the degradation of cytosolic proteins at the ubiquitination step...
  10. ncbi request reprint A rat model of human FENIB (familial encephalopathy with neuroserpin inclusion bodies)
    Katsura Takano
    Department of Neuroanatomy, Kanazawa University Medical School, Ishikawa, Japan
    Biochem Biophys Res Commun 346:1040-7. 2006
    ..Tg meg rats provide a novel model of FENIB, where accumulation of serpins in the ER induces selective dysfunction/loss of specific neuronal populations...
  11. pmc Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress
    Osamu Hori
    Department of Neuroanatomy, Kanazawa University, Graduate School of Medical Science, 13 1 Takara machi, Kanazawa City, Ishikawa 920 8640, Japan
    Mol Cell Biol 26:4257-67. 2006
    ....
  12. ncbi request reprint The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes
    Kentaro Ozawa
    Department of Neuroanatomy, Kanazawa University Medical School, 13 1, Takara machi, Kanazawa City, Ishikawa, 920 8640, Japan
    Diabetes 54:657-63. 2005
    ..Furthermore, ORP150 enhanced the insulin sensitivity of myoblast cells treated with hydrogen peroxide. These data suggest that ORP150 plays an important role in insulin sensitivity and is a potential target for the treatment of diabetes...
  13. ncbi request reprint ORP150/HSP12A regulates Purkinje cell survival: a role for endoplasmic reticulum stress in cerebellar development
    Yasuko Kitao
    Department of Neuroanatomy, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    J Neurosci 24:1486-96. 2004
    ..These data suggest that ER chaperones have a pivotal role in Purkinje cell survival and death and thus may highlight the importance of ER stress in neuronal development...
  14. ncbi request reprint Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin
    Katsura Takano
    Department of Neuroanatomy, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa City, Ishikawa 920 8640, Japan
    Am J Physiol Cell Physiol 292:C353-61. 2007
    ..These results suggest that methoxyflavones play an important role in the regulation of ER stress and could be a therapeutic target for the ER stress-related diseases...
  15. ncbi request reprint Ischemia-induced neuronal cell death and stress response
    Satoshi Ogawa
    Department of Neuroanatomy, Kanazawa University Medical School, Takara machi, Kanazawa City, Ishikawa, Japan
    Antioxid Redox Signal 9:573-87. 2007
    ..Because hypoxia, another major factor in ischemia, results in further dysfunction of the ER, studies on the malfunction of this cellular organelle may facilitate the development of novel strategies to block ischemia-induced cell death...
  16. ncbi request reprint [Neuronal cell death and stress response]
    Satoshi Ogawa
    Department of Neuroanatomy, KLanazawa University Medical School, 13 1 Takara machi, Kanazawa City, Ishikawa 920 8640, Japan
    Seikagaku 78:973-8. 2006
  17. doi request reprint RAGE mediates vascular injury and inflammation after global cerebral ischemia
    Tomoya Kamide
    Department of Neurosurgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa 920 8640, Japan
    Neurochem Int 60:220-8. 2012
    ..These results suggest that RAGE may contribute to delayed neuronal death after global cerebral ischemia by enhancing vascular injury and deleterious glia-mediated inflammation...
  18. doi request reprint α-Lipoic acid (LA) enantiomers protect SH-SY5Y cells against glutathione depletion
    Takashi Yamada
    Graduate School of Natural Science and Technology, Division of Material Engineering, Kanazawa University, Kanazawa, Ishikawa, Japan
    Neurochem Int 59:1003-9. 2011
    ..Our results suggest an important role of PI3K/Akt-mediated upregulation of genes including phase II enzymes such as NQO1 in LA-mediated neuroprotection...
  19. ncbi request reprint Antitumor effect of reduction of 150-kDa oxygen-regulated protein expression on human prostate cancer cells
    Tohru Miyagi
    Department of Urology, Kanazawa University School of Medicine, Kanazawa, Japan
    Int J Urol 9:577-85. 2002
    ....
  20. doi request reprint The effect of Ndrg2 expression on astroglial activation
    Toshiaki Takeichi
    Department of Legal Medicine, Kanazawa Medical University, Ishikawa, Japan
    Neurochem Int 59:21-7. 2011
    ..These results suggest that Ndrg2 may regulate astroglial activation through the suppression of cell proliferation and stabilization of cell morphology...
  21. doi request reprint Glutamate preferentially suppresses osteoblastogenesis than adipogenesis through the cystine/glutamate antiporter in mesenchymal stem cells
    Mika Takarada-Iemata
    Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kanazawa, Ishikawa, Japan
    J Cell Physiol 226:652-65. 2011
    ....
  22. doi request reprint 3,4-dihydroxybenzalacetone protects against Parkinson's disease-related neurotoxin 6-OHDA through Akt/Nrf2/glutathione pathway
    Kei Gunjima
    School of Natural System Bioengineering Course, College of Science and Engineering, Kanazawa University, Kanazawa, Ishikawa, Japan
    J Cell Biochem 115:151-60. 2014
    ..Buthionine sulfoximine, an inhibitor of glutathione synthesis, but not Sn-mesoporphyrin IX, a heme oxygenase-1 inhibitor, or dicoumarol, an..
  23. ncbi request reprint Expression of 150-kd oxygen-regulated protein in the hippocampus suppresses delayed neuronal cell death
    Mayuki Miyazaki
    Department of Neuroanatomy, Kanazawa University Medical School, Kanazawa City, Ishikawa, Japan
    J Cereb Blood Flow Metab 22:979-87. 2002
    ..These data suggest a possible function of ORP150 as an intracellular apparatus that participates in a protective response in ischemic tolerance...