H Higashida

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. pmc The roles of oxytocin and CD38 in social or parental behaviors
    Olga Lopatina
    Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University Krasnoyarsk, Russia
    Front Neurosci 6:182. 2012
  2. ncbi request reprint Integrative neurochemistry and neurobiology of social recognition and behavior analyzed with respect to CD38-dependent brain oxytocin secretion
    Alla B Salmina
    Research Center for Child Mental Development, Kanazawa University, Takara machi 13 1, Kanazawa, 920 8640, Japan
    Curr Top Med Chem 13:2965-77. 2013
  3. pmc CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice
    Shirin Akther
    Kanazawa University Center for Child Mental Development, Kanazawa 920 8640, Japan
    Mol Brain 6:41. 2013
  4. ncbi request reprint [CD38 and autism spectrum disorders]
    Haruhiro Higashida
    Kanazawa University Center for Child Mental Development, Kanazawa, Ishikawa
    No To Hattatsu 45:431-5. 2013
  5. ncbi request reprint A personal view from a long-lasting collaborator on the research strategies of Marshall Nirenberg
    Haruhiro Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Neurochem Int 61:821-7. 2012
  6. ncbi request reprint Social memory, amnesia, and autism: brain oxytocin secretion is regulated by NAD+ metabolites and single nucleotide polymorphisms of CD38
    Haruhiro Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Neurochem Int 61:828-38. 2012
  7. doi request reprint CD38 and its role in oxytocin secretion and social behavior
    Haruhiro Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Horm Behav 61:351-8. 2012
  8. pmc Decreased expression of axon-guidance receptors in the anterior cingulate cortex in autism
    Shiro Suda
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu 431 3192 Japan
    Mol Autism 2:14. 2011
  9. ncbi request reprint Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca2+ signalling in rodent NG108-15 neuroblastoma cells
    Haruhiro Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Neurosci Res 57:339-46. 2007
  10. ncbi request reprint Protein kinase C bound with A-kinase anchoring protein is involved in muscarinic receptor-activated modulation of M-type KCNQ potassium channels
    Haruhiro Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Neurosci Res 51:231-4. 2005

Collaborators

Detail Information

Publications65

  1. pmc The roles of oxytocin and CD38 in social or parental behaviors
    Olga Lopatina
    Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University Krasnoyarsk, Russia
    Front Neurosci 6:182. 2012
    ..In addition, preliminary studies of continuous nasal OXT administration on subjects with autism spectrum disorders are described...
  2. ncbi request reprint Integrative neurochemistry and neurobiology of social recognition and behavior analyzed with respect to CD38-dependent brain oxytocin secretion
    Alla B Salmina
    Research Center for Child Mental Development, Kanazawa University, Takara machi 13 1, Kanazawa, 920 8640, Japan
    Curr Top Med Chem 13:2965-77. 2013
    ..Current approaches to the modulation of both CD38 expression and brain cell activity that represent prospective treatments for disorders associated with altered social behavior are discussed...
  3. pmc CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice
    Shirin Akther
    Kanazawa University Center for Child Mental Development, Kanazawa 920 8640, Japan
    Mol Brain 6:41. 2013
    ..In this paper, we studied CD38 in the nucleus accumbens (NAcc) and the role of OT on paternal pup retrieval behavior using CD38 knockout (CD38-/-) mice of the ICR strain...
  4. ncbi request reprint [CD38 and autism spectrum disorders]
    Haruhiro Higashida
    Kanazawa University Center for Child Mental Development, Kanazawa, Ishikawa
    No To Hattatsu 45:431-5. 2013
    ..These results suggest that SNPs in CD38 may be risk factors for ASD by abrogating the OXT function, and that some ASD subjects can be treated with OXT in preliminary clinical trials...
  5. ncbi request reprint A personal view from a long-lasting collaborator on the research strategies of Marshall Nirenberg
    Haruhiro Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Neurochem Int 61:821-7. 2012
    ..Especially he liked his hypothesis for opiate tolerance and dependency as a model of cellular memory. Through these studies, he seemed to devote all his time of about 50 years from 1960s to decoding brain memory processes...
  6. ncbi request reprint Social memory, amnesia, and autism: brain oxytocin secretion is regulated by NAD+ metabolites and single nucleotide polymorphisms of CD38
    Haruhiro Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Neurochem Int 61:828-38. 2012
    ..These results suggest that SNPs in CD38 may be possible risk factors for ASD by abrogating OXT function and that some ASD subjects can be treated with OXT in preliminary clinical trials...
  7. doi request reprint CD38 and its role in oxytocin secretion and social behavior
    Haruhiro Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Horm Behav 61:351-8. 2012
    ..This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior...
  8. pmc Decreased expression of axon-guidance receptors in the anterior cingulate cortex in autism
    Shiro Suda
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu 431 3192 Japan
    Mol Autism 2:14. 2011
    ..abstract:..
  9. ncbi request reprint Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca2+ signalling in rodent NG108-15 neuroblastoma cells
    Haruhiro Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Neurosci Res 57:339-46. 2007
    ..These results indicate that cADPR is an intracellular messenger of Ca(2+) signalling, suggesting that CD38 can contribute to mAChR-cADPR signalling...
  10. ncbi request reprint Protein kinase C bound with A-kinase anchoring protein is involved in muscarinic receptor-activated modulation of M-type KCNQ potassium channels
    Haruhiro Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Neurosci Res 51:231-4. 2005
    ..However, before this identity is confirmed, many other modulators which affect M-currents remain to be addressed as intriguing issues...
  11. ncbi request reprint Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells
    Haruhiro Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    J Neurochem 85:1148-58. 2003
    ..Thus, the subtype-specific coupling of mGluRs to ADP-ribosyl cyclase via G proteins suggests that some glutamate-evoked neuronal functions are mediated by cADP-ribose...
  12. ncbi request reprint Measurement of adenylyl cyclase by separating cyclic AMP on silica gel thin-layer chromatography
    Haruhiro Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Japan
    Anal Biochem 308:106-11. 2002
    ..This simple and rapid isolation method provides a novel and convenient technique for the assay of adenylyl cyclase...
  13. ncbi request reprint Bradykinin activates ADP-ribosyl cyclase in neuroblastoma cells: intracellular concentration decrease in NAD and increase in cyclic ADP-ribose
    Haruhiro Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, 13 1 Takara, Kanazawa, Ishikawa 920 8640, Japan
    FEBS Lett 580:4857-60. 2006
    ..In contrast, intracellular cADPR concentrations were increased by 2-3-fold during the period from 30 to 120s after the same treatment. Our results suggest that cADPR is one of the second messengers downstream of B(2) BK receptors...
  14. ncbi request reprint Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system
    Haruhiro Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Neurochem Int 51:192-9. 2007
    ....
  15. ncbi request reprint [Biological basis for social recognition: CD38 controls oxytocin secretion]
    Haruhiro Higashida
    Tanpakushitsu Kakusan Koso 52:1832-9. 2007
  16. ncbi request reprint Oxytocin signal and social behaviour: comparison among adult and infant oxytocin, oxytocin receptor and CD38 gene knockout mice
    H Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    J Neuroendocrinol 22:373-9. 2010
    ..These results suggest that secretion of oxytocin into the brain in a CD38-dependent manner may play an important role in the development of social behaviour...
  17. pmc Endomorphins inhibit high-threshold Ca2+ channel currents in rodent NG108-15 cells overexpressing mu-opioid receptors
    H Higashida
    Department of Biophysics, Kanazawa University School of Medicine, Kanazawa 920, Japan
    J Physiol 507:71-5. 1998
    ....
  18. ncbi request reprint CD38 gene knockout juvenile mice: a model of oxytocin signal defects in autism
    Haruhiro Higashida
    Department of Biophysical Genetics, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan
    Biol Pharm Bull 34:1369-72. 2011
    ....
  19. ncbi request reprint Cyclic ADP-ribose as a second messenger revisited from a new aspect of signal transduction from receptors to ADP-ribosyl cyclase
    H Higashida
    Department of Biophysical Genetics, Molecular Medicine and Bioinformatics, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, 920 8640, Kanazawa, Japan
    Pharmacol Ther 90:283-96. 2001
    ..These findings suggest that cADPR is a second messenger in cellular Ca(2+) signaling. However, many intriguing issues remain to be addressed before this identity is confirmed...
  20. ncbi request reprint ADP-ribosyl cyclase coupled with receptors via G proteins
    H Higashida
    Department of Biophysics, NIRI, Kanazawa University School of Medicine, Japan
    FEBS Lett 418:355-6. 1997
    ....
  21. ncbi request reprint Sympathetic potentiation of cyclic ADP-ribose formation in rat cardiac myocytes
    H Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    J Biol Chem 274:33348-54. 1999
    ....
  22. ncbi request reprint Cyclic ADP-ribose as a potential second messenger for neuronal Ca2+ signaling
    H Higashida
    Department of Biophysical Genetics, Molecular Medicine and Bioinformatics, Kanazawa University Graduate School of Medicine, Japan
    J Neurochem 76:321-31. 2001
    ..These findings strongly suggest that cADPR is a second messenger in Ca2+ signaling in the nervous system, although many intriguing issues remain to be addressed before this identity is confirmed...
  23. ncbi request reprint Potential mechanism for bradykinin-activated and inositol tetrakisphosphate-dependent Ca2+ influx by Ras and GAP1 in fibroblast cells
    H Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Japan
    Immunopharmacology 45:7-11. 1999
    ....
  24. ncbi request reprint Muscarinic receptor-mediated dual regulation of ADP-ribosyl cyclase in NG108-15 neuronal cell membranes
    H Higashida
    Department of Biophysics, Kanazawa University School of Medicine, Kanazawa, Japan
    J Biol Chem 272:31272-7. 1997
    ..These results suggest that mAChRs couple to ADP-ribosyl cyclase within cell membranes via trimeric G proteins and can thereby control cellular function by regulating cADP-ribose formation...
  25. pmc Angiotensin II stimulates cyclic ADP-ribose formation in neonatal rat cardiac myocytes
    H Higashida
    Department of Biochemical Genetics, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Biochem J 352:197-202. 2000
    ....
  26. ncbi request reprint Signal transduction from bradykinin, angiotensin, adrenergic and muscarinic receptors to effector enzymes, including ADP-ribosyl cyclase
    H Higashida
    Department of Biophysical Genetics, Molecular Medicine and Bioinformatics, Kanazawa University Graduate School of Medicine, Japan
    Biol Chem 382:23-30. 2001
    ..cADPR also functions through activating calcineurin released from A-kinase anchoring protein (AKAP79). Thus, some G(q/11)-coupled receptors can control cADPR-dependent modulation in Ca2+ signaling...
  27. ncbi request reprint Ca2+ release and Ca2+ influx in Chinese hamster ovary cells expressing the cloned mouse B2 bradykinin receptor: tyrosine kinase inhibitor-sensitive and- insensitive processes
    M Taketo
    Department of Biophysics, Kanazawa University School of Medicine, Japan
    Biochim Biophys Acta 1355:89-98. 1997
    ....
  28. pmc Overexpression of rat neuronal calcium sensor-1 in rodent NG108-15 cells enhances synapse formation and transmission
    X L Chen
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920-8640, Japan
    J Physiol 532:649-59. 2001
    ..The mean number of quanta per impulse (m) increased 5-fold. These results show that NCS-1 functions to facilitate synapse formation, probably because of the increased quantal content of evoked acetylcholine release...
  29. ncbi request reprint B2 bradykinin receptors in NG108-15 cells: cDNA cloning and functional expression
    S Yokoyama
    Department of Biophysics, Neuroinformation Research Institute, Kanazawa University School of Medicine, Japan
    Biochem Biophys Res Commun 200:634-41. 1994
    ..These results suggest that both the rat and mouse B2 BKRs of the smooth muscle type are expressed in NG108-15 cells...
  30. ncbi request reprint KCR1, a membrane protein that facilitates functional expression of non-inactivating K+ currents associates with rat EAG voltage-dependent K+ channels
    N Hoshi
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    J Biol Chem 273:23080-5. 1998
    ..Far-Western blotting revealed that KCR1 and EAG proteins interacted with each other by means of their C-terminal regions. These results suggest that KCR1 is the regulatory component of non-inactivating K+ channels...
  31. pmc cADP-ribose potentiates cytosolic Ca2+ elevation and Ca2+ entry via L-type voltage-activated Ca2+ channels in NG108-15 neuronal cells
    M Hashii
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Biochem J 345:207-15. 2000
    ..These results suggest that cADPR functions on ryanodine receptors as a direct agonist and also interacts with L-type VACCs as an indirect agonist, i.e. via a retrograde signal...
  32. ncbi request reprint Intracellular calcium elevation induced by extracellular application of cyclic-ADP-ribose or oxytocin is temperature-sensitive in rodent NG108-15 neuronal cells with or without exogenous expression of human oxytocin receptors
    S Amina
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    J Neuroendocrinol 22:460-6. 2010
    ....
  33. ncbi request reprint Ba2+ current oscillations modulated by cyclic AMP and phorbol esters in ras-transformed fibroblasts
    H Higashida
    Department of Biophysics, Kanazawa University School of Medicine, Japan
    Biochem Biophys Res Commun 182:1240-5. 1992
    ..The results suggest that Ba2+ current oscillations are regulated by intracellular second messengers...
  34. pmc 12-Lipoxygenase overexpression in rodent NG108-15 cells enhances membrane excitability by inhibiting M-type K+ channels
    Y Takahashi
    Department of Pharmacology, Kanazawa University School of Medicine, Japan
    J Physiol 521:567-74. 1999
    ..5. These results indicate that 12-lipoxygenase and/or its metabolites target K+ channels and upregulate the membrane excitability, and thereby modulate neuronal signalling...
  35. doi request reprint Reproductive experience affects parental retrieval behaviour associated with increased plasma oxytocin levels in wild-type and CD38-knockout mice
    O Lopatina
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    J Neuroendocrinol 23:1125-33. 2011
    ..These results indicate that parental behaviour is improved by reproductive experience, especially in Cd38 (-/-) dams, and suggest that these effects may be a result of increased oxytocin levels...
  36. pmc AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists
    Naoto Hoshi
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    Nat Neurosci 6:564-71. 2003
    ..These inhibitors also reduced muscarinic inhibition of M-current. Our data indicate that AKAP150-bound PKC participates in receptor-induced inhibition of the M-current...
  37. ncbi request reprint Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG
    Kenshi Hayashi
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Clin Sci (Lond) 107:175-82. 2004
    ....
  38. ncbi request reprint Cholinergic synapse formation between NG108-15 and muscle cells and modulation of transmission
    H Higashida
    Department of Biophysics, Kanazawa University School of Medicine, Japan
    Neurosci Res Suppl 13:S75-9. 1990
    ..Since bradykinin increases the level of intracellular inositol 1,4,5-trisphosphate (InsP3), bradykinin-induced facilitation is due to InsP3-dependent elevation of intracellular Ca concentrations...
  39. ncbi request reprint CD38/cyclic ADP-ribose system: a new player for oxytocin secretion and regulation of social behaviour
    A B Salmina
    Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University, Krasnoyarsk 660022, Russia
    J Neuroendocrinol 22:380-92. 2010
    ....
  40. ncbi request reprint cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter
    H Takanaga
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kanazawa University, Japan
    Biochem Biophys Res Commun 217:370-7. 1995
    ..These results indicate that MCT1 contributes to pH-dependent and carrier-mediated transport of monocarboxylic acids in many tissues, not just in the small intestine...
  41. ncbi request reprint CD38 is critical for social behaviour by regulating oxytocin secretion
    Duo Jin
    Kanazawa University 21st Century COE Program on Innovative Brain Science on Development, Learning and Memory, Kanazawa 920 8640, Japan
    Nature 446:41-5. 2007
    ..These results reveal that CD38 has a key role in neuropeptide release, thereby critically regulating maternal and social behaviours, and may be an element in neurodevelopmental disorders...
  42. ncbi request reprint Two genetic variants of CD38 in subjects with autism spectrum disorder and controls
    Toshio Munesue
    Kanazawa University 21st Century Center of Excellence COE Program on Innovative Brain Science on Development, Learning and Memory, Kanazawa 920 8640, Japan
    Neurosci Res 67:181-91. 2010
    ..One proband with the T allele who was taking nasal OT spray showed relief of symptoms. The two variant CD38 poloymorphysms tested may be of interest with regard of the pathophysiology of ASD...
  43. ncbi request reprint Induction of interleukin-6 in dorsal root ganglion neurons after gradual elongation of rat sciatic nerve
    Naoki Osamura
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Exp Neurol 195:61-70. 2005
    ..These results suggest that IL-6 plays a key role in biochemical responses in peripheral sensory neurons after gradual nerve elongation...
  44. ncbi request reprint Clinical and electrophysiological characterization of a novel mutation (F193L) in the KCNQ1 gene associated with long QT syndrome
    Masato Yamaguchi
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8641, Japan
    Clin Sci (Lond) 104:377-82. 2003
    ..This electrophysiological study indicates that F193L causes less severe KCNQ1 current suppression, and thereby this mutation may result in a mildly affected phenotype...
  45. ncbi request reprint Characterization of a novel missense mutation E637K in the pore-S6 loop of HERG in a patient with long QT syndrome
    Kenshi Hayashi
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University 13 1, Takara machi, Ishikawa 920 8640, Japan
    Cardiovasc Res 54:67-76. 2002
    ..Therefore, we investigated the role of a glutamic acid at the vicinity of the pore in HERG channels by mutating it to a lysine...
  46. ncbi request reprint Amplification of depolarization-induced and ryanodine-sensitive cytosolic Ca2+ elevation by synthetic carbocyclic analogs of cyclic ADP-ribose and their antagonistic effects in NG108-15 neuronal cells
    Minako Hashii
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    J Neurochem 94:316-23. 2005
    ....
  47. doi request reprint Long QT syndrome and associated gene mutation carriers in Japanese children: results from ECG screening examinations
    Kenshi Hayashi
    Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Clin Sci (Lond) 117:415-24. 2009
    ..038% (one in 2653). Furthermore, large-scale genetic studies will be needed to clarify the real prevalence of LQTS by gene-carrier status, as it may have been underestimated in the present study...
  48. doi request reprint A KCR1 variant implicated in susceptibility to the long QT syndrome
    Kenshi Hayashi
    Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Mol Cell Cardiol 50:50-7. 2011
    ..Our findings suggest that KCR1 genetic variations that diminish the ability of KCR1 to protect KCNH2 from inhibition by commonly used therapeutic agents constitute a risk factor for the aLQTS...
  49. ncbi request reprint Muscarinic acetylcholine receptor subtypes in the human iris
    N Ishizaka
    Department of Biophysics, Kanazawa University School of Medicine, Kanazawa 920 8640, Japan
    Brain Res 787:344-7. 1998
    ..In dilator muscle cells, weak but not consistent immunoreactivity was found by anti-m1 and -m5 antibodies. The results suggest that the m3 muscarinic receptor is the predominant subtype in sphincter muscle cells of the human iris...
  50. doi request reprint Oxytocin-induced elevation of ADP-ribosyl cyclase activity, cyclic ADP-ribose or Ca(2+) concentrations is involved in autoregulation of oxytocin secretion in the hypothalamus and posterior pituitary in male mice
    Olga Lopatina
    Kanazawa University 21st Century Center of Excellence Program on Innovative Brain Science on Development, Learning and Memory, Kanazawa 920 8640, Japan
    Neuropharmacology 58:50-5. 2010
    ....
  51. ncbi request reprint Induction of tumor necrosis factor-alpha in Schwann cells after gradual elongation of rat sciatic nerve
    Norio Hagiwara
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    J Orthop Sci 10:614-21. 2005
    ..The purpose of this study was to clarify whether expression of cytokines and neurotrophins is altered in gradually elongated peripheral nerves...
  52. pmc RNA interference screen to identify genes required for Drosophila embryonic nervous system development
    Keita Koizumi
    Kanazawa University, 21st Century Centers of Excellence Program on Innovative Brain Science on Development, Learning, and Memory, Kanazawa 920 8640, Japan
    Proc Natl Acad Sci U S A 104:5626-31. 2007
    ..The total number of dsRNAs that we have tested for an RNAi-induced phenotype affecting the embryonic nervous system, including our previous study, is 7,312, which corresponds to approximately 50% of the genes in the Drosophila genome...
  53. ncbi request reprint Acetylcholine stimulates cyclic ADP-ribose formation via M1 muscarinic receptors in rat superior cervical ganglion
    Jia Sheng Zhang
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Biochem Biophys Res Commun 335:920-4. 2005
    ..These results indicate that the M1 mAChRs couple to the membrane-bound form of ADP-ribosyl cyclase and suggest that cADPR is a second messenger of M1 mAChR signaling in nervous tissue...
  54. doi request reprint Locomotor activity, ultrasonic vocalization and oxytocin levels in infant CD38 knockout mice
    Hong Xiang Liu
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Neurosci Lett 448:67-70. 2008
    ..These results showed that the reduced severity of behavioral abnormalities in CD38(-/-) pups was due to partial compensation by the high level of plasma OT...
  55. ncbi request reprint Expression of a Rho guanine nucleotide exchange factor, Ect2, in the developing mouse pituitary
    M S Islam
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    J Neuroendocrinol 22:477-82. 2010
    ..Taken together, the results demonstrate the functional role of Ect2 in postnatal proliferating cells in the two lobes of the pituitary, thereby suggesting roles in developmental growth of the mammalian pituitary...
  56. ncbi request reprint Mouse B2 bradykinin receptor gene maps to distal chromosome 12
    M Taketo
    Department of Biophysics, Kanazawa University School of Medicine, Kanazawa 920, Japan
    Genomics 27:222-3. 1995
  57. ncbi request reprint Identification of calreticulin as a marker for phagocytosis of apoptotic cells in Drosophila
    Takayuki Kuraishi
    Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920 1192, Japan
    Exp Cell Res 313:500-10. 2007
    ..These results collectively indicate that calreticulin is the first molecule to be identified as a marker for phagocytosis of apoptotic cells by Drosophila phagocytes...
  58. pmc Decreased ADP-ribosyl cyclase activity in peripheral blood mononuclear cells from diabetic patients with nephropathy
    Michio Ohtsuji
    Division of Endocrinology and Diabetology, Kanazawa University Graduate School of Medicine, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    Exp Diabetes Res 2008:897508. 2008
    ..This study aimed to investigate the connection between ADPRCA in PBMCs and diabetic complications...
  59. ncbi request reprint Cyclin-dependent kinase 5 activators p35 and p39 facilitate formation of functional synapses
    Jenny U Johansson
    Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Brain Res Mol Brain Res 138:215-27. 2005
    ..These findings demonstrate that Cdk5, p35, and p39 are endogenously expressed in NG108-15 cells, exhibit distinct subcellular localizations, and that both Cdk5/p35 and Cdk5/p39 are central in formation of functional synapses...
  60. ncbi request reprint Compound heterozygosity for mutations Asp611-->Tyr in KCNQ1 and Asp609-->Gly in KCNH2 associated with severe long QT syndrome
    Masato Yamaguchi
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    Clin Sci (Lond) 108:143-50. 2005
    ..Our results suggest that the mild phenotype produced by the D611Y mutation in KCNQ1 became more serious by addition of the D609G mutation in KCNH2 in the proband...
  61. ncbi request reprint Synthesis of stable and cell-type selective analogues of cyclic ADP-ribose, a Ca(2+)-mobilizing second messenger. Structure--activity relationship of the N1-ribose moiety
    Takashi Kudoh
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    J Am Chem Soc 127:8846-55. 2005
    ..Thus, this study represents an entry to cell-type selective cADPR analogues, which can be used as biological tools and/or novel drug leads...
  62. ncbi request reprint Multiple signal transduction pathways mediated by 5-HT receptors
    Mami Noda
    Laboratory of Pathophysiology, Kyushu University Graduate School of Pharmaceutical Sciences, Fukuoka 812 8582, Japan
    Mol Neurobiol 29:31-9. 2004
    ..The investigation of these serotonergic signaling and its impairment at cellular level may help to understand the symptoms of brain diseases...
  63. ncbi request reprint Recombinant human serotonin 5A receptors stably expressed in C6 glioma cells couple to multiple signal transduction pathways
    Mami Noda
    Laboratory of Pathophysiology, Kyushu University Graduate School of Pharmaceutical Sciences, Fukuoka, Japan
    J Neurochem 84:222-32. 2003
    ..These multiple signal transduction systems may induce complex changes in the serotonergic system in brain function...
  64. pmc Genes required for Drosophila nervous system development identified by RNA interference
    Andrej I Ivanov
    Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:16216-21. 2004
    ..The functions of some of the genes are unknown. Other genes encode protein kinases, transcription factors, and signaling proteins, as well as proteins with other functions...
  65. ncbi request reprint [Genome-wide analysis by RNA interference of genes that affect Drosophila nervous system development]
    Keita Koizumi
    The Fly Group, Kanazawa University 21st COE Project on Innovative Brain Science for Development, Learning and Memory
    Fukuoka Igaku Zasshi 96:67-75. 2005