Naoyuki Hayashi

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi request reprint Mutations in Ran system affected telomere silencing in Saccharomyces cerevisiae
    Naoyuki Hayashi
    Department of Molecular Pathology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920 0934, Japan
    Biochem Biophys Res Commun 363:788-94. 2007
  2. ncbi request reprint STM1, a gene which encodes a guanine quadruplex binding protein, interacts with CDC13 in Saccharomyces cerevisiae
    N Hayashi
    Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    Mol Genet Genomics 267:806-13. 2002
  3. ncbi request reprint The SIT4 gene, which encodes protein phosphatase 2A, is required for telomere function in Saccharomyces cerevisiae
    Naoyuki Hayashi
    Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa, 920 0934, Japan
    Curr Genet 47:359-67. 2005
  4. ncbi request reprint Temperature-sensitive defects of the GSP1gene, yeast Ran homologue, activate the Tel1-dependent pathway
    Naoyuki Hayashi
    Department of Molecular Pathology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    Biochem Biophys Res Commun 353:330-6. 2007
  5. ncbi request reprint NBS1 directly activates ATR independently of MRE11 and TOPBP1
    Masahiko Kobayashi
    Department of Molecular Pathology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, 920 1192, Japan
    Genes Cells 18:238-46. 2013
  6. ncbi request reprint Mutational analysis of human RNA polymerase II subunit 5 (RPB5): the residues critical for interactions with TFIIF subunit RAP30 and hepatitis B virus X protein
    Thi Thu Thuy Le
    Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, Takara machi 13 1, Kanazawa 920 0934, Japan
    J Biochem 138:215-24. 2005
  7. ncbi request reprint Nucleolin interacts with telomerase
    Shilagardi Khurts
    Department of Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa 920 0934, Japan
    J Biol Chem 279:51508-15. 2004
  8. doi request reprint c-ABL tyrosine kinase stabilizes RAD51 chromatin association
    Hiroko Shimizu
    Department of Molecular Pathology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
    Biochem Biophys Res Commun 382:286-91. 2009
  9. ncbi request reprint Mutational Analysis of Hepatitis C Virus NS5B in the Subgenomic Replicon Cell Culture
    Yuanyuan Ma
    Department of Molecular Oncology, Cancer Research Institute, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    J Biol Chem 279:25474-82. 2004
  10. doi request reprint Regulatory interaction between NBS1 and DNMT1 responding to DNA damage
    Naoyuki Hayashi
    Division of Molecular Pathology and Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920 1192, Japan
    J Biochem 154:429-35. 2013

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Mutations in Ran system affected telomere silencing in Saccharomyces cerevisiae
    Naoyuki Hayashi
    Department of Molecular Pathology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920 0934, Japan
    Biochem Biophys Res Commun 363:788-94. 2007
    ..Furthermore, hyperphosphorylated Sir3 protein accumulated in the rna1-1 mutant. These results suggest that RanGAP is required for the heterochromatin structure at the telomere in budding yeast...
  2. ncbi request reprint STM1, a gene which encodes a guanine quadruplex binding protein, interacts with CDC13 in Saccharomyces cerevisiae
    N Hayashi
    Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    Mol Genet Genomics 267:806-13. 2002
    ..Although STM1 itself is not essential for telomere replication, our findings suggest that STM1 genetically interacts with CDC13 to maintain telomere structure...
  3. ncbi request reprint The SIT4 gene, which encodes protein phosphatase 2A, is required for telomere function in Saccharomyces cerevisiae
    Naoyuki Hayashi
    Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa, 920 0934, Japan
    Curr Genet 47:359-67. 2005
    ..The sit4 mutant was found to have altered nucleoli and a life span as short as an sgs1 mutant. These observations suggest that the PP2A pathway regulates life span in yeast...
  4. ncbi request reprint Temperature-sensitive defects of the GSP1gene, yeast Ran homologue, activate the Tel1-dependent pathway
    Naoyuki Hayashi
    Department of Molecular Pathology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    Biochem Biophys Res Commun 353:330-6. 2007
    ..These results indicated that Rad53 was activated by the Tel1 pathway in mec1 gsp1 cells, suggesting that Gsp1 helps regulate the role switching the ATM family kinases Mec1 and Tel1...
  5. ncbi request reprint NBS1 directly activates ATR independently of MRE11 and TOPBP1
    Masahiko Kobayashi
    Department of Molecular Pathology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, 920 1192, Japan
    Genes Cells 18:238-46. 2013
    ..These results therefore indicate that NBS1 and TOPBP1 have the potential to activate ATR independently, although both are required for functional activation of ATR in vivo...
  6. ncbi request reprint Mutational analysis of human RNA polymerase II subunit 5 (RPB5): the residues critical for interactions with TFIIF subunit RAP30 and hepatitis B virus X protein
    Thi Thu Thuy Le
    Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, Takara machi 13 1, Kanazawa 920 0934, Japan
    J Biochem 138:215-24. 2005
    ..Interestingly the residues exposed to solvent, T111 and S113, are very close to the DNA, implying that two factors may modulate the interaction between DNA and RPB5...
  7. ncbi request reprint Nucleolin interacts with telomerase
    Shilagardi Khurts
    Department of Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa 920 0934, Japan
    J Biol Chem 279:51508-15. 2004
    ..These findings indicate that interaction of hTERT and nucleolin participates in the dynamic intracellular localization of telomerase complex...
  8. doi request reprint c-ABL tyrosine kinase stabilizes RAD51 chromatin association
    Hiroko Shimizu
    Department of Molecular Pathology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
    Biochem Biophys Res Commun 382:286-91. 2009
    ..Our findings suggest a new model for the regulation of early steps of HRR...
  9. ncbi request reprint Mutational Analysis of Hepatitis C Virus NS5B in the Subgenomic Replicon Cell Culture
    Yuanyuan Ma
    Department of Molecular Oncology, Cancer Research Institute, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    J Biol Chem 279:25474-82. 2004
    ..However, heat- and dilution-sensitive NS5Bs exhibiting weaker RdRP activity in vitro were found to be replication-incompetent, suggesting that HCV replication requires RdRP activity higher than a certain critical threshold...
  10. doi request reprint Regulatory interaction between NBS1 and DNMT1 responding to DNA damage
    Naoyuki Hayashi
    Division of Molecular Pathology and Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920 1192, Japan
    J Biochem 154:429-35. 2013
    ..These results suggest that DNMT1 function in the regulatory response is controlled by NBS1. ..
  11. pmc Subcellular localization of RPB5-mediating protein and its putative functional partner
    Luvsanjav Delgermaa
    Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, Takara machi 13 1, Kanazawa 920 0934, Japan
    Mol Cell Biol 24:8556-66. 2004
    ..These results are discussed in light of a recent paper showing a novel evolutionarily conserved role of URI in the TOR signaling pathway...
  12. pmc ATM mediates pRB function to control DNMT1 protein stability and DNA methylation
    Awad Shamma
    Division of Oncology and Molecular Biology, Kanazawa University, Kanazawa, Ishikawa, Japan
    Mol Cell Biol 33:3113-24. 2013
    ..Our results indicate that inactivation of the pRB pathway in coordination with aberration in the DNA damage response deregulates DNMT1 stability, leading to an abnormal DNA methylation pattern and malignant progression. ..
  13. ncbi request reprint Oligomeric interaction of hepatitis C virus NS5B is critical for catalytic activity of RNA-dependent RNA polymerase
    Weiping Qin
    Department Molecular Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0924, Japan
    J Biol Chem 277:2132-7. 2002
    ..These results clearly indicate that two residues of HCV NS5B are critical for the oligomerization that is prerequisite to RdRP activity...
  14. doi request reprint Genetic evidence that Ras-like GTPases, Gtr1p, and Gtr2p, are involved in epigenetic control of gene expression in Saccharomyces cerevisiae
    Takeshi Sekiguchi
    Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 368:748-54. 2008
    ..We propose that Gtr1p and Gtr2p are involved in epigenetic control of gene expression in the TOR signaling pathway...
  15. ncbi request reprint Suppressor analysis of the mpt5/htr1/uth4/puf5 deletion in Saccharomyces cerevisiae
    Kentaro Ohkuni
    Division of Molecular Mycology and Medicine, Center for Neurological Disease and Cancer, Graduate School of Medicine, Nagoya University, 466 8550 Nagoya, Japan
    Mol Genet Genomics 275:81-8. 2006
    ..The protein level of Puf4 was not affected by the sir mutation. Thus, these Ime4 and Puf4 proteins play complementary roles to rescue the defects in Deltampt5 Deltasir cells...