Research Topics
Genomes and Genes | Naoyuki HayashiSummaryAffiliation: Kanazawa University Country: Japan Publications
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Publications
Mutations in Ran system affected telomere silencing in Saccharomyces cerevisiaeNaoyuki Hayashi
Department of Molecular Pathology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920 0934, Japan
Biochem Biophys Res Commun 363:788-94. 2007..Furthermore, hyperphosphorylated Sir3 protein accumulated in the rna1-1 mutant. These results suggest that RanGAP is required for the heterochromatin structure at the telomere in budding yeast...- STM1, a gene which encodes a guanine quadruplex binding protein, interacts with CDC13 in Saccharomyces cerevisiaeN Hayashi
Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
Mol Genet Genomics 267:806-13. 2002..Although STM1 itself is not essential for telomere replication, our findings suggest that STM1 genetically interacts with CDC13 to maintain telomere structure... - Temperature-sensitive defects of the GSP1gene, yeast Ran homologue, activate the Tel1-dependent pathwayNaoyuki Hayashi
Department of Molecular Pathology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
Biochem Biophys Res Commun 353:330-6. 2007..These results indicated that Rad53 was activated by the Tel1 pathway in mec1 gsp1 cells, suggesting that Gsp1 helps regulate the role switching the ATM family kinases Mec1 and Tel1... - The SIT4 gene, which encodes protein phosphatase 2A, is required for telomere function in Saccharomyces cerevisiaeNaoyuki Hayashi
Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa, 920 0934, Japan
Curr Genet 47:359-67. 2005..The sit4 mutant was found to have altered nucleoli and a life span as short as an sgs1 mutant. These observations suggest that the PP2A pathway regulates life span in yeast... - Mutational analysis of human RNA polymerase II subunit 5 (RPB5): the residues critical for interactions with TFIIF subunit RAP30 and hepatitis B virus X proteinThi Thu Thuy Le
Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, Takara machi 13 1, Kanazawa 920 0934, Japan
J Biochem 138:215-24. 2005..Interestingly the residues exposed to solvent, T111 and S113, are very close to the DNA, implying that two factors may modulate the interaction between DNA and RPB5... - Nucleolin interacts with telomeraseShilagardi Khurts
Department of Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa 920 0934, Japan
J Biol Chem 279:51508-15. 2004..These findings indicate that interaction of hTERT and nucleolin participates in the dynamic intracellular localization of telomerase complex... 
c-ABL tyrosine kinase stabilizes RAD51 chromatin associationHiroko Shimizu
Department of Molecular Pathology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
Biochem Biophys Res Commun 382:286-91. 2009..Our findings suggest a new model for the regulation of early steps of HRR...- Mutational Analysis of Hepatitis C Virus NS5B in the Subgenomic Replicon Cell CultureYuanyuan Ma
Department of Molecular Oncology, Cancer Research Institute, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
J Biol Chem 279:25474-82. 2004..However, heat- and dilution-sensitive NS5Bs exhibiting weaker RdRP activity in vitro were found to be replication-incompetent, suggesting that HCV replication requires RdRP activity higher than a certain critical threshold... 
Subcellular localization of RPB5-mediating protein and its putative functional partnerLuvsanjav Delgermaa
Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, Takara machi 13 1, Kanazawa 920 0934, Japan
Mol Cell Biol 24:8556-66. 2004..These results are discussed in light of a recent paper showing a novel evolutionarily conserved role of URI in the TOR signaling pathway...- Oligomeric interaction of hepatitis C virus NS5B is critical for catalytic activity of RNA-dependent RNA polymeraseWeiping Qin
Department Molecular Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-0924, Japan
J Biol Chem 277:2132-7. 2002..These results clearly indicate that two residues of HCV NS5B are critical for the oligomerization that is prerequisite to RdRP activity... - Suppressor analysis of the mpt5/htr1/uth4/puf5 deletion in Saccharomyces cerevisiaeKentaro Ohkuni
Division of Molecular Mycology and Medicine, Center for Neurological Disease and Cancer, Graduate School of Medicine, Nagoya University, 466-8550 Nagoya, Japan
Mol Genet Genomics 275:81-8. 2006..The protein level of Puf4 was not affected by the sir mutation. Thus, these Ime4 and Puf4 proteins play complementary roles to rescue the defects in Deltampt5 Deltasir cells... - Genetic evidence that Ras-like GTPases, Gtr1p, and Gtr2p, are involved in epigenetic control of gene expression in Saccharomyces cerevisiaeTakeshi Sekiguchi
Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
Biochem Biophys Res Commun 368:748-54. 2008..We propose that Gtr1p and Gtr2p are involved in epigenetic control of gene expression in the TOR signaling pathway...