Minoru Hasegawa

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. doi request reprint The loss of MCP-1 attenuates cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer
    Yuki Saito
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Invest Dermatol 128:1838-51. 2008
  2. doi request reprint Skin sclerosis as a manifestation of POEMS syndrome
    Minoru Hasegawa
    Department of Dermatology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    J Dermatol 39:922-6. 2012
  3. doi request reprint Clinical and laboratory features dependent on age at onset in Japanese systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa, 920 8641, Japan
    Mod Rheumatol 23:913-9. 2013
  4. doi request reprint Serum chemokine levels as prognostic markers in patients with early systemic sclerosis: a multicenter, prospective, observational study
    Minoru Hasegawa
    Department of Dermatology, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa, 920 8641, Japan
    Mod Rheumatol 23:1076-84. 2013
  5. doi request reprint Altered expression of dermokine in skin disorders
    M Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
    J Eur Acad Dermatol Venereol 27:867-75. 2013
  6. doi request reprint Dermokine inhibits ELR(+)CXC chemokine expression and delays early skin wound healing
    Minoru Hasegawa
    Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan
    J Dermatol Sci 70:34-41. 2013
  7. doi request reprint Anti-topoisomerase I antibody levels as serum markers of skin sclerosis in systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    J Dermatol 40:89-93. 2013
  8. doi request reprint Augmented ICOS expression in patients with early diffuse cutaneous systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Rheumatology (Oxford) 52:242-51. 2013
  9. doi request reprint Potential immunologic targets for treating fibrosis in systemic sclerosis: a review focused on leukocytes and cytokines
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Semin Arthritis Rheum 42:281-96. 2012
  10. ncbi request reprint Anti-phosphatidylserine-prothrombin complex antibodies in patients with localized scleroderma
    M Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Clin Exp Rheumatol 24:19-24. 2006

Detail Information

Publications111 found, 100 shown here

  1. doi request reprint The loss of MCP-1 attenuates cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer
    Yuki Saito
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Invest Dermatol 128:1838-51. 2008
    ..We propose that this is a useful model for investigating the mechanism of pressure ulcer formation using various transgenic mice...
  2. doi request reprint Skin sclerosis as a manifestation of POEMS syndrome
    Minoru Hasegawa
    Department of Dermatology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    J Dermatol 39:922-6. 2012
    ..To our knowledge, this is the first report to discuss in detail the differentiation between POEMS syndrome and systemic sclerosis...
  3. doi request reprint Clinical and laboratory features dependent on age at onset in Japanese systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa, 920 8641, Japan
    Mod Rheumatol 23:913-9. 2013
    ..To clarify those clinical characteristics dependent on patient age at onset of Japanese systemic sclerosis (SSc)...
  4. doi request reprint Serum chemokine levels as prognostic markers in patients with early systemic sclerosis: a multicenter, prospective, observational study
    Minoru Hasegawa
    Department of Dermatology, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa, 920 8641, Japan
    Mod Rheumatol 23:1076-84. 2013
    ..To assess the utility of serum chemokine levels as a prognostic indicator of disease progression in systemic sclerosis (SSc) patients with early onset disease...
  5. doi request reprint Altered expression of dermokine in skin disorders
    M Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
    J Eur Acad Dermatol Venereol 27:867-75. 2013
    ..Although dermokine-β, a glycoprotein expressed in epithelial cells, does not have significant homology to other proteins, its carboxyl-terminal domain shares a high pI value with many cytokines, suggesting similar functions...
  6. doi request reprint Dermokine inhibits ELR(+)CXC chemokine expression and delays early skin wound healing
    Minoru Hasegawa
    Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan
    J Dermatol Sci 70:34-41. 2013
    ..We have recently shown that treatment of keratinocytes with dermokine-β attenuates phosphorylation of extracellular signal-regulated kinase, however, the roles of dermokine-β in vivo remain unknown...
  7. doi request reprint Anti-topoisomerase I antibody levels as serum markers of skin sclerosis in systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    J Dermatol 40:89-93. 2013
    ..Our findings suggest that serum levels of anti-topoisomerase I Ab reflect the severity of skin sclerosis in patients with SSc...
  8. doi request reprint Augmented ICOS expression in patients with early diffuse cutaneous systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Rheumatology (Oxford) 52:242-51. 2013
    ..Here we investigated the expression of ICOS and ICOSL in patients with SSc...
  9. doi request reprint Potential immunologic targets for treating fibrosis in systemic sclerosis: a review focused on leukocytes and cytokines
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Semin Arthritis Rheum 42:281-96. 2012
    ....
  10. ncbi request reprint Anti-phosphatidylserine-prothrombin complex antibodies in patients with localized scleroderma
    M Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Clin Exp Rheumatol 24:19-24. 2006
    ..We investigated anti-PS/PT Ab levels in patients with LSc...
  11. doi request reprint Use of serum clara cell 16-kDa (CC16) levels as a potential indicator of active pulmonary fibrosis in systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa, Japan
    J Rheumatol 38:877-84. 2011
    ....
  12. doi request reprint A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Arthritis Rheum 60:3465-75. 2009
    ....
  13. doi request reprint B lymphocytes: shedding new light on the pathogenesis of systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920 8641, Japan
    J Dermatol 37:3-10. 2010
    ..As B cells have a variety of functions, further investigation into the pathogenic roles of B cells, as well as trials of B-cell-targeting therapies, may shed new light on the pathogenesis of SSc...
  14. pmc Up regulated expression of fractalkine/CX3CL1 and CX3CR1 in patients with systemic sclerosis
    M Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920 8641, Japan
    Ann Rheum Dis 64:21-8. 2005
    ..Fractalkine expressed on endothelial cells mediates activation and adhesion of leucocytes expressing its receptor, CX(3)CR1. Soluble fractalkine exhibits chemotactic activity for leucocytes expressing CX(3)CR1...
  15. pmc Autoantibodies against phosphatidylserine-prothrombin complex in patients with systemic sclerosis
    M Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Ann Rheum Dis 63:1514-7. 2004
    ..To determine the frequency and clinical association of antiphosphatidylserine-prothrombin complex (PS/PT) antibody (Ab) in systemic sclerosis (SSc)...
  16. doi request reprint Dermoscopy findings of nail fold capillaries in connective tissue diseases
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Dermatol 38:66-70. 2011
    ..In this review, I summarized the established capillaroscopy findings in connective tissues diseases and tried to apply the findings of dermoscopy to the findings and classification of capillaroscopy...
  17. doi request reprint Serum chemokine and cytokine levels as indicators of disease activity in patients with systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa, 920 8641, Japan
    Clin Rheumatol 30:231-7. 2011
    ..However, a longer-term prospective study in a larger population will be needed to confirm its clinical utility as predictors of outcomes...
  18. doi request reprint Investigation of prognostic factors for skin sclerosis and lung function in Japanese patients with early systemic sclerosis: a multicentre prospective observational study
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Rheumatology (Oxford) 51:129-33. 2012
    ..It is well known that ethnic variations exist in the clinical features and severity of SSc. However, neither the clinical course nor prognostic factors have been thoroughly investigated in the Japanese population...
  19. ncbi request reprint The roles of chemokines in leukocyte recruitment and fibrosis in systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Front Biosci 13:3637-47. 2008
    ..Here recent data will be reviewed on the pathogenic role of chemokines and their receptors in SSc...
  20. ncbi request reprint Augmented production of transforming growth factor-beta by cultured peripheral blood mononuclear cells from patients with systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Arch Dermatol Res 296:89-93. 2004
    ..Thus, the enhanced production of TGF-beta by PBMC may contribute to the disease process in SSc..
  21. ncbi request reprint Pathogenesis of systemic sclerosis: altered B cell function is the key linking systemic autoimmunity and tissue fibrosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Dermatol Sci 39:1-7. 2005
    ..Thus, altered B cell function may result in tissue fibrosis, as well as autoimmunity, in SSc...
  22. ncbi request reprint Serum levels of tumor necrosis factor and interleukin-13 are elevated in patients with localized scleroderma
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Dermatology 207:141-7. 2003
    ..The enhanced production of some cytokines may be related to the pathogenesis of localized scleroderma (LSc)...
  23. pmc Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model
    Ayumi Yoshizaki
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Immunol 185:2502-15. 2010
    ....
  24. ncbi request reprint Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice
    Yukiyo Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 179:698-707. 2007
    ..Thus, our findings indicate that ICAM-1 expression contributes to the development of skin fibrosis in TSK/+ mice, especially via ICAM-1 expressed on skin fibroblasts...
  25. pmc Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction
    Toshihide Hara
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8501, Japan
    Am J Pathol 176:259-69. 2010
    ....
  26. pmc B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Japan
    Am J Pathol 169:954-66. 2006
    ..Thereby, B-cell depletion during disease onset suppressed skin fibrosis, indicating that B cells contribute to the initiation of systemic sclerosis pathogenesis in tight-skin mice but are not required for disease maintenance...
  27. pmc Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction
    Takayuki Ishii
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 174:2225-33. 2009
    ..The IgE-mediated cutaneous reverse passive Arthus reaction may serve as an experimental model for cutaneous eosinophilic infiltration in vasculitis as well as in other diseases...
  28. ncbi request reprint Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1
    Toru Yukami
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1, Takara machi, Kanazawa 920 8641, Japan
    J Leukoc Biol 82:519-31. 2007
    ..These results indicate that skin wound healing is regulated cooperatively by all selectins and ICAM-1 and may provide critical information for the therapy of skin wounds...
  29. pmc E- and P-selectins synergistically inhibit bleomycin-induced pulmonary fibrosis
    Mayuka Horikawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 169:740-9. 2006
    ..These results suggest that E- and P-selectins synergistically inhibit lung fibrosis by promoting the recruitment of NKT cells...
  30. pmc The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity
    Asako Ogawa
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, Japan
    J Invest Dermatol 130:1558-70. 2010
    ..These results suggest that ICAM-1 mediates Th1 cell recruitment irrespective of DNFB or FITC and that L-selectin recruits Th1 cells in Th1-type CHS, whereas it recruits Th2 cells in Th2-type CHS...
  31. doi request reprint Low zone tolerance requires ICAM-1 expression to limit contact hypersensitivity elicitation
    Kazuhiro Komura
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan
    J Invest Dermatol 129:2661-7. 2009
    ..These results indicate that low-dose tolerization controls CHS by abrogating ICAM-1 upregulation during the elicitation phase...
  32. doi request reprint P-selectin glycoprotein ligand-1 contributes to wound healing predominantly as a p-selectin ligand and partly as an e-selectin ligand
    Hajime Tomita
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Invest Dermatol 129:2059-67. 2009
    ..These results suggest that PSGL-1 contributes to wound healing predominantly as a P-selectin ligand and partly as an E-selectin ligand by mediating infiltration of inflammatory cells...
  33. ncbi request reprint L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity
    Yuka Shimada
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 170:4325-34. 2003
    ....
  34. ncbi request reprint Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 cooperatively contribute to the cutaneous Arthus reaction
    Hidemitsu Orito
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    J Leukoc Biol 81:1197-204. 2007
    ..Thus, VCAM-1 plays a complementary role to ICAM-1 in the cutaneous Arthus reaction by regulating leukocyte accumulation and proinflammatory cytokine production...
  35. pmc CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse
    Eriko Saito
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Clin Invest 109:1453-62. 2002
    ..CD19 deficiency also inhibited IL-6 production by TSK/+ B cells. Thus, chronic B cell activation resulting from augmented CD19 signaling in TSK/+ mice leads to skin sclerosis possibly through IL-6 overproduction as well as autoimmunity...
  36. doi request reprint Increased serum pentraxin 3 in patients with systemic sclerosis
    Yohei Iwata
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Rheumatol 36:976-83. 2009
    ..To determine serum concentrations of pentraxin 3 (PTX3) and its clinical associations in patients with systemic sclerosis (SSc)...
  37. pmc CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma
    Ayumi Yoshizaki
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Am J Pathol 172:1650-63. 2008
    ....
  38. ncbi request reprint Ultraviolet light exposure suppresses contact hypersensitivity by abrogating endothelial intercellular adhesion molecule-1 up-regulation at the elicitation site
    Kazuhiro Komura
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Immunol 171:2855-62. 2003
    ..These results indicate that UV exposure inhibits CHS by abrogating up-regulation of endothelial ICAM-1 expression after Ag challenge at elicitation sites...
  39. doi request reprint Inducible costimulator ligand regulates bleomycin-induced lung and skin fibrosis in a mouse model independently of the inducible costimulator/inducible costimulator ligand pathway
    Chihiro Tanaka
    Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Arthritis Rheum 62:1723-32. 2010
    ..Although the ICOS/ICOSL pathway is known to play various roles in adaptive immunity, its roles in innate immunity and tissue fibrosis remain unknown...
  40. ncbi request reprint Serum pulmonary and activation-regulated chemokine/CCL18 levels in patients with systemic sclerosis: a sensitive indicator of active pulmonary fibrosis
    Masanari Kodera
    Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Arthritis Rheum 52:2889-96. 2005
    ....
  41. doi request reprint Elevated serum concentrations of triggering receptor expressed on myeloid cells-1 in diffuse cutaneous systemic sclerosis: association with severity of pulmonary fibrosis
    Hajime Tomita
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan
    J Rheumatol 37:787-91. 2010
    ..To determine serum concentrations and clinical association of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in patients with systemic sclerosis (SSc)...
  42. pmc Phase-dependent roles of E-selectin during chronic contact hypersensitivity responses
    Tomoyuki Fujita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 170:1649-58. 2007
    ..Collectively, P- and E-selectins cooperatively regulate CH response, although their roles may be different depending on the phase of the reaction...
  43. ncbi request reprint Antigen specificity of antihistone antibodies in connective tissue disease patients with anti-U1RNP antibodies
    Takamasa Wayaku
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Rheumatol Int 28:113-9. 2007
    ..The antigenic stimulus in SLE may be different from other connective tissue diseases and is more likely to be native chromatin...
  44. ncbi request reprint Clinical significance of serum hyaluronan levels in systemic sclerosis: association with disease severity
    Ayumi Yoshizaki
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Rheumatol 35:1825-9. 2008
    ..To determine any clinical association of serum levels of hyaluronan in patients with systemic sclerosis (SSc)...
  45. pmc Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced lung fibrosis
    Yasuhito Hamaguchi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Am J Pathol 161:1607-18. 2002
    ..This suggests that these adhesion molecules are potential therapeutic targets for inhibiting human pulmonary fibrosis...
  46. doi request reprint Serum CXCL16 concentrations correlate with the extent of skin sclerosis in patients with systemic sclerosis
    Koichi Yanaba
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Rheumatol 36:1917-23. 2009
    ..To determine serum concentrations of soluble CXCL16 and its clinical associations in patients with systemic sclerosis (SSc)...
  47. doi request reprint Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease
    Doanh Le Huu
    Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920 8641, Japan
    Blood 121:3274-83. 2013
    ..Therefore, donor-derived B10 cells have a suppressive role in Scl-cGVHD development, warranting future investigation of regulatory B-cell-based therapy for treatment of Scl-cGVHD and SSc...
  48. ncbi request reprint Elevated serum levels of APRIL, but not BAFF, in patients with atopic dermatitis
    Takashi Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Exp Dermatol 17:197-202. 2008
    ..These results suggest that elevated serum levels of APRIL are associated with disease severity and activity in AD, and APRIL may have an important role in the pathogenesis of AD...
  49. ncbi request reprint L-selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury
    Ayako Kawasuji
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1, Takara machi, Kanazawa, 920 8641, Japan
    J Leukoc Biol 79:696-705. 2006
    ..These results indicate that L-selectin and ICAM-1 contribute cooperatively to the development of Con A-induced hepatitis by regulating leukocyte infiltration and subsequent cytokine production...
  50. ncbi request reprint Serum levels of a Th1 chemoattractant IP-10 and Th2 chemoattractants, TARC and MDC, are elevated in patients with systemic sclerosis
    Hidetaka Fujii
    Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Dermatol Sci 35:43-51. 2004
    ..Although abnormalities of various chemokines are detected in systemic sclerosis (SSc), there are few findings concerning Th1 or Th2 chemoattractants...
  51. ncbi request reprint BAFF antagonist attenuates the development of skin fibrosis in tight-skin mice
    Takashi Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Invest Dermatol 127:2772-80. 2007
    ..The results suggest that BAFF/BAFF receptor system is critical for the development of skin fibrosis in TSK/+ mice and could be a potent therapeutical target...
  52. ncbi request reprint Increased serum soluble CD40 levels in patients with systemic sclerosis
    Kazuhiro Komura
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    J Rheumatol 34:353-8. 2007
    ..To determine serum levels of soluble CD40 (sCD40) and clinical association in patients with systemic sclerosis (SSc)...
  53. ncbi request reprint Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid
    Makoto Inaoki
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Autoimmun 27:196-202. 2006
    ..These results suggest that a decrease in CD22 expression may not be associated with BP-specific antibody production...
  54. doi request reprint Autoantibody against one of the antioxidant repair enzymes, methionine sulfoxide reductase A, in systemic sclerosis: association with pulmonary fibrosis and vascular damage
    Fumihide Ogawa
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Arch Dermatol Res 302:27-35. 2010
    ..These results suggest that elevated anti-MSRA autoantibody is associated with the disease severity of SSc and may enhance the oxidative stress by inhibiting MSRA enzymatic activity...
  55. pmc Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response
    Takashi Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 168:812-21. 2006
    ..Thus, CD19 modulates the Th1/Th2 cytokine balance in B cells and plays a critical role as a suppressive molecule in the development of EAE...
  56. pmc CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling
    Yohei Iwata
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Am J Pathol 175:649-60. 2009
    ..Thus, this study is the first to reveal a critical role of B cells and novel mechanisms in wound healing...
  57. doi request reprint Autoantibody against caspase-3, an executioner of apoptosis, in patients with systemic sclerosis
    Shihoko Okazaki
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Rheumatol Int 30:871-8. 2010
    ..These results suggest that autoantibody against caspase-3 is generated in SSc and that this Ab is related to the severity of pulmonary fibrosis, vascular damage, and inflammation...
  58. doi request reprint Decreased levels of autoantibody against histone deacetylase 3 in patients with systemic sclerosis
    Yutaka Kuwatsuka
    Department of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    Autoimmunity 42:120-5. 2009
    ..These results indicate the lack of anti-HDAC-3 autoantibody in SSc patients, which is produced in healthy individuals as well as DM and SLE patients, suggesting that this autoantibody might function as protective Ab...
  59. doi request reprint Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis: association with pulmonary fibrosis
    Toshihide Hara
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Rheumatol 36:99-105. 2009
    ..To determine the serum concentrations and clinical association of polymorphonuclear neutrophilic leukocyte (PMN) elastase in patients with systemic sclerosis (SSc)...
  60. doi request reprint Elevated serum interleukin-27 levels in patients with systemic sclerosis: association with T cell, B cell and fibroblast activation
    Ayumi Yoshizaki
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Ann Rheum Dis 70:194-200. 2011
    ..To determine serum levels of interleukin 27 (IL-27) in patients with systemic sclerosis (SSc) and relate the results to the clinical features of SSc...
  61. ncbi request reprint Anti-p53 autoantibody in systemic sclerosis: association with limited cutaneous systemic sclerosis
    Toshihide Hara
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Rheumatol 35:451-7. 2008
    ..To determine the prevalence and clinical significance of anti-p53 antibody in patients with systemic sclerosis (SSc)...
  62. doi request reprint Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: association with disease severity
    Ayumi Yoshizaki
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan
    J Clin Immunol 29:180-9. 2009
    ..However, the association of this system in systemic sclerosis (SSc) remains unknown...
  63. doi request reprint FTY720 ameliorates murine sclerodermatous chronic graft-versus-host disease by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin
    Doanh Le Huu
    Kanazawa University, Kanazawa, Japan
    Arthritis Rheum 65:1624-35. 2013
    ..Murine sclerodermatous chronic graft-versus-host disease (GVHD) is a model for human sclerodermatous chronic GVHD and SSc. We undertook this study to investigate the effects of FTY720 in murine sclerodermatous chronic GVHD...
  64. doi request reprint B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells
    Guihua Jin
    Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    J Allergy Clin Immunol 131:1674-82. 2013
    ..B-cell linker protein (BLNK) is an essential component of the B-cell antigen receptor signaling pathway and is required for optimal B-cell development...
  65. doi request reprint Association between nail-fold capillary findings and disease activity in dermatomyositis
    Naoki Mugii
    Department of Rehabilitation, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
    Rheumatology (Oxford) 50:1091-8. 2011
    ..Our objective was to assess the changes and red blood cell velocity in finger nail-fold capillaries using nail-fold video capillaroscopy (NVC) in patients with adult-onset DM...
  66. ncbi request reprint Increased serum soluble OX40 in patients with systemic sclerosis
    Kazuhiro Komura
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Rheumatol 35:2359-62. 2008
    ..To determine levels of serum soluble OX40 (also termed CD134, a member of the tumor necrosis factor receptor superfamily) and their clinical associations in patients with systemic sclerosis (SSc)...
  67. ncbi request reprint Clinical evaluation of anti-aminoacyl tRNA synthetase antibodies in Japanese patients with dermatomyositis
    Takashi Matsushita
    Department of Dermatology and Division of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Rheumatol 34:1012-8. 2007
    ..To investigate the distribution of anti-aminoacyl-tRNA synthetase (anti-ARS) antibodies among patients with autoimmune diseases, and to analyze the clinical features of patients with dermatomyositis (DM) with anti-ARS antibodies...
  68. doi request reprint Basophils and mast cells play critical roles for leukocyte recruitment in IgE-mediated cutaneous reverse passive Arthus reaction
    Guihua Jin
    Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    J Dermatol Sci 67:181-9. 2012
    ..This uniquely provides a model of type III hypersensitivity in which Fc classes of Ig that forms immune complex differentially determine the disease manifestation...
  69. ncbi request reprint Anti-DNA topoisomerase II alpha autoantibodies in Japanese patients with systemic sclerosis
    Ikuko Hayakawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Arch Dermatol Res 297:180-3. 2005
    ..The results of the present study indicate that anti-topo II alpha Ab represent one of the autoantibody specificities detected on SSc patients and may be regarded a serological marker of pulmonary fibrosis in Japanese patients with SSc...
  70. ncbi request reprint Abnormal natural killer cell function in systemic sclerosis: altered cytokine production and defective killing activity
    Mayuka Horikawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Invest Dermatol 125:731-7. 2005
    ..These results suggested that altered NK cell function contributes to immunological abnormalities in SSc...
  71. ncbi request reprint [Scleroderma]
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science
    Nihon Rinsho 63:295-9. 2005
  72. doi request reprint Elevated circulating TWEAK levels in systemic sclerosis: association with lower frequency of pulmonary fibrosis
    Koichi Yanaba
    Department of Dermatology, Nagasaki University GraduateSchool of Biomedical Sciences, Nagasaki and Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Rheumatol 36:1657-62. 2009
    ..To determine serum levels of tumor necrosis factor-related weak inducer of apoptosis (TWEAK) and its clinical associations in patients with systemic sclerosis (SSc)...
  73. doi request reprint Autoantibodies against matrix metalloproteinase-1 in patients with localized scleroderma
    Saori Tomimura
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, Japan
    J Dermatol Sci 52:47-54. 2008
    ..Localized scleroderma (LSc) is characterized by cutaneous fibrosis and various autoantibodies...
  74. ncbi request reprint Expression of fractalkine and its receptor, CX3CR1, in atopic dermatitis: possible contribution to skin inflammation
    Takeshi Echigo
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    J Allergy Clin Immunol 113:940-8. 2004
    ..Fractalkine (FKN) induces activation and adhesion of leukocytes expressing its receptor, CX(3)CR1. FKN is released from the cell surface through proteolytic cleavage as soluble FKN (sFKN)...
  75. doi request reprint Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multicenter cross-sectional study
    Yasuhito Hamaguchi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Arch Dermatol 147:391-8. 2011
    ..To clarify the association of clinical and prognostic features with dermatomyositis (DM)-specific autoantibodies (Abs) in adult Japanese patients with DM...
  76. ncbi request reprint Both Th1 and Th2 chemokines are elevated in sera of patients with autoimmune blistering diseases
    Takeshi Echigo
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Arch Dermatol Res 298:38-45. 2006
    ..These results suggest that both a Th1 chemoattractant MIG and Th2 chemoattractants, TARC and MDC, cooperatively play a role in the development of ABD...
  77. ncbi request reprint Longitudinal analysis of serum cytokine concentrations in systemic sclerosis: association of interleukin 12 elevation with spontaneous regression of skin sclerosis
    Takashi Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Japan
    J Rheumatol 33:275-84. 2006
    ..We investigated the relationship between changes of the serum cytokine profile and changes in skin fibrosis in patients with SSc...
  78. ncbi request reprint Antiphospholipid antibodies in patients with autoimmune blistering disease
    Takeshi Echigo
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa 920 8641, Japan
    J Am Acad Dermatol 57:397-400. 2007
    ..Our purpose was to determine the serum levels and frequency of antiphospholipid antibodies (aPLs) and confirm the clinical importance of these antibodies in patients with autoimmune blistering disease (ABD)...
  79. ncbi request reprint Altered blood B lymphocyte homeostasis in systemic sclerosis: expanded naive B cells and diminished but activated memory B cells
    Shinichi Sato
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Arthritis Rheum 50:1918-27. 2004
    ..To determine phenotypic and functional abnormalities of blood B cell subsets in patients with systemic sclerosis (SSc)...
  80. ncbi request reprint The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression
    Yuko Kaburagi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 168:2970-8. 2002
    ....
  81. ncbi request reprint Function blocking autoantibodies against matrix metalloproteinase-1 in patients with systemic sclerosis
    Shinichi Sato
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Japan
    J Invest Dermatol 120:542-7. 2003
    ....
  82. ncbi request reprint Novel autoantibody to Cu/Zn superoxide dismutase in patients with localized scleroderma
    Masaki Nagai
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Invest Dermatol 122:594-601. 2004
    ....
  83. doi request reprint Esophageal transit study using a sliding sum image: application to patients with probable and definite systemic sclerosis
    Kenichi Nakajima
    Department of Nuclear Medicine, Kanazawa University Hospital, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    Ann Nucl Med 25:325-31. 2011
    ..The aim of this study was to develop a new algorithm for integrating a dynamic esophageal transit study and to apply the method to patients with SSc...
  84. ncbi request reprint Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis
    Shinichi Sato
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Mol Immunol 41:1123-33. 2004
    ..Thus, chronic B cell activation resulting from augmented CD19 signaling leads to skin fibrosis possibly through IL-6 overproduction, as well as autoantibody production, in tight-skin mice and SSc patients...
  85. doi request reprint Esophageal transit scintigraphy and structured questionnaire in patients with systemic sclerosis with endoscopically proven reflux esophagitis
    Kenichi Nakajima
    Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Japan
    Ann Nucl Med 23:771-6. 2009
    ..The relationship between gastroesophageal reflux (GER) symptoms and dysmotility was examined in endoscopically confirmed patients suspected of having reflux esophagitis...
  86. doi request reprint Re-emergence of anti-topoisomerase I antibody with exacerbated development of skin sclerosis in a patient with systemic sclerosis
    Yasuhito Hamaguchi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Am Acad Dermatol 62:142-4. 2010
    ..This case suggests a role for anti-topo I in the pathogenesis of systemic sclerosis and an effect of corticosteroids on skin sclerosis and autoantibody production...
  87. ncbi request reprint Myocardial damages in systemic sclerosis detected by gated myocardial perfusion SPECT and sympathetic imaging
    Kenichi Nakajima
    Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa 920 8641, Japan
    Circ J 70:1481-7. 2006
    ....
  88. ncbi request reprint Improvement of skin sclerosis after occurrence of anticentromere antibody in a patient with diffuse cutaneous systemic sclerosis
    Ikuko Hayakawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Clin Rheumatol 23:345-7. 2004
    ..This case is very rare because such a case was not reported previously...
  89. doi request reprint Elevated serum insulin-like growth factor (IGF-1) and IGF binding protein-3 levels in patients with systemic sclerosis: possible role in development of fibrosis
    Yasuhito Hamaguchi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Rheumatol 35:2363-71. 2008
    ..To examine serum concentrations of insulin-like growth factor (IGF-1) and IGF binding protein (IGFBP-3), a major carrier protein for IGF-1, in patients with systemic sclerosis (SSc); and to relate the results to clinical features in SSc...
  90. ncbi request reprint Elevation of serum lymphotactin levels in patients with systemic sclerosis
    Eiji Muroi
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Rheumatol 35:834-8. 2008
    ..To determine serum concentrations of lymphotactin, a Th1 chemokine, and their clinical association in patients with systemic sclerosis (SSc)...
  91. ncbi request reprint Increased serum interleukin 23 in patients with systemic sclerosis
    Kazuhiro Komura
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Rheumatol 35:120-5. 2008
    ..We investigated serum IL-23 levels and their clinical association in patients with SSc...
  92. ncbi request reprint [B lymphocyte]
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science
    Nihon Rinsho Meneki Gakkai Kaishi 28:300-8. 2005
    ..This review focuses on recent data demonstrating the roles of B cells in autoimmune diseases as well as the current studies concerning the treatment of autoimmune diseases by Rituximab...
  93. ncbi request reprint Comparative study of serum surfactant protein-D and KL-6 concentrations in patients with systemic sclerosis as markers for monitoring the activity of pulmonary fibrosis
    Koichi Yanaba
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Rheumatol 31:1112-20. 2004
    ..To clarify the clinical significance of surfactant protein-D (SP-D) and KL-6 in the diagnosis and monitoring of pulmonary fibrosis (PF) in patients with systemic sclerosis (SSc), and to evaluate the differences between SP-D and KL-6...
  94. ncbi request reprint Elevated serum BAFF levels in patients with systemic sclerosis: enhanced BAFF signaling in systemic sclerosis B lymphocytes
    Takashi Matsushita
    Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Arthritis Rheum 54:192-201. 2006
    ..To determine serum levels of BAFF, a potent B cell survival factor, in patients with systemic sclerosis (SSc) and relate the results to the clinical features of SSc...
  95. ncbi request reprint Serum concentrations of the CXC chemokines interleukin 8 and growth-regulated oncogene-alpha are elevated in patients with systemic sclerosis
    Shinobu Furuse
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    J Rheumatol 30:1524-8. 2003
    ....
  96. ncbi request reprint Mouse CD20 expression and function
    Junji Uchida
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Int Immunol 16:119-29. 2004
    ..Thus, mouse and human CD20 share similar patterns of expression and function. These studies thereby provide an animal model for studying CD20 function in vivo and the molecular mechanisms that influence anti-CD20 immunotherapy...
  97. ncbi request reprint A case of scleroderma spectrum disorder with anticentriole antibody and pulmonary hypertension
    Ikuko Hayakawa
    Department of Dermatology, Kanazawa University, Graduate School of Medical Science, 13 1 Takaramachi, Ishikawa 920 8641 Kanazawa, Japan
    Clin Rheumatol 23:266-8. 2004
    ..She was diagnosed as SSD with pulmonary hypertension. This is the first case of SSD with anticentriole antibody to develop pulmonary hypertension...
  98. ncbi request reprint Clinical characteristics of juvenile systemic sclerosis in Japanese
    Maki Murata
    J Rheumatol 32:1850-2. 2005
  99. ncbi request reprint Elevated circulating CD40L concentrations in patients with systemic sclerosis
    Kazuhiro Komura
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Rheumatol 31:514-9. 2004
    ..Since these effects are characteristic in patients with systemic sclerosis (SSc), serum concentrations of sCD40L were determined in patients with SSc...
  100. ncbi request reprint Elevated serum BAFF levels in patients with localized scleroderma in contrast to other organ-specific autoimmune diseases
    Takashi Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Exp Dermatol 16:87-93. 2007
    ..By contrast, serum BAFF levels were not significantly elevated in patients with pemphigus or pemphigoid. These results suggest that BAFF may be contributing to autoimmunity and disease development in localized scleroderma...
  101. pmc B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse
    Noriko Asano
    Department of Regenerative Medicine, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Am J Pathol 165:641-50. 2004
    ....