Fujikawa Yamamoto K, Miyagoshi M, Yamagishi H. Establishment of a tetraploid cell line from mouse H-1 (ES) cells highly polyploidized with demecolcine. Cell Prolif. 2007;40:327-37 pubmed
..4nH1 cells exhibited alkaline phosphatase activity and formed teratocarcinomas, implying that they would be pluripotent. A pluripotent tetraploid cell line (4nH1 cells) was established. ..
Fujikawa Yamamoto K, Luo X, Miyagoshi M, Yamagishi H. DNA stable pentaploid H1 (ES) cells obtained from an octaploid cell induced from tetraploid cells polyploidized using demecolcine. J Cell Physiol. 2010;223:369-75 pubmed publisher
..The excellent stability of the DNA content of 5H1 cells was explained using a hypothesis for the DNA structure of polyploid cells because the pairing of homologous chromosomes in 5H1 cells is spatially forbidden. ..
Fujikawa Yamamoto K, Miyagoshi M, Luo X, Yamagishi H. DNA-unstable decaploid mouse H1 (ES) cells established from DNA-stable pentaploid H1 (ES) cells polyploidized using demecolcine. Cell Prolif. 2011;44:111-9 pubmed publisher
..In the pentaploid-decaploid transition of H1 cells, cell cycle parameters and pluripotency were retained, but morphology and DNA stability were altered. ..