Tadayuki Akagi

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. pmc Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations
    Tadayuki Akagi
    Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, Los Angeles, CA, USA
    Blood 113:1741-8. 2009
  2. pmc In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response
    Tadayuki Akagi
    Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America
    PLoS ONE 5:e15419. 2010
  3. pmc Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells
    Tadayuki Akagi
    Department of Stem Cell Biology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa, Japan
    Haematologica 94:1301-6. 2009
  4. pmc Chromosomal abnormalities and novel disease-related regions in progression from Barrett's esophagus to esophageal adenocarcinoma
    Tadayuki Akagi
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA, USA
    Int J Cancer 125:2349-59. 2009
  5. pmc Functional analysis of a novel DNA polymorphism of a tandem repeated sequence in the asparagine synthetase gene in acute lymphoblastic leukemia cells
    Tadayuki Akagi
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Leuk Res 33:991-6. 2009
  6. pmc Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype
    Tadayuki Akagi
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Haematologica 94:213-23. 2009
  7. pmc Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells
    Chuanhai Sun
    Department of Stem Cell Biology, Graduate School of Medical Science, Kanazawa University, Ishikawa 920 8640, Japan
    Mol Cell Biol 29:4574-83. 2009
  8. pmc Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia
    Ryoko Okamoto
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, 8700, Beverly Blvd, Los Angeles, CA90048, USA
    Haematologica 95:1481-8. 2010
  9. doi request reprint STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells
    Hiroki Ura
    Department of Stem Cell Biology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    J Biol Chem 283:9713-23. 2008
  10. pmc Eed/Sox2 regulatory loop controls ES cell self-renewal through histone methylation and acetylation
    Hiroki Ura
    Department of Stem Cell Biology, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan
    EMBO J 30:2190-204. 2011

Detail Information

Publications21

  1. pmc Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations
    Tadayuki Akagi
    Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, Los Angeles, CA, USA
    Blood 113:1741-8. 2009
    ..Here, we showed for the first time hidden abnormalities and novel disease-related genomic changes in t(15;17) APL...
  2. pmc In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response
    Tadayuki Akagi
    Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America
    PLoS ONE 5:e15419. 2010
    ....
  3. pmc Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells
    Tadayuki Akagi
    Department of Stem Cell Biology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa, Japan
    Haematologica 94:1301-6. 2009
    ..Importantly, prognostic analysis revealed that overall survival and event-free survival of individuals in Group B were significantly worse than those in Group A...
  4. pmc Chromosomal abnormalities and novel disease-related regions in progression from Barrett's esophagus to esophageal adenocarcinoma
    Tadayuki Akagi
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA, USA
    Int J Cancer 125:2349-59. 2009
    ..Thus, this SNP-chip analysis has identified several early cytogenetic events and novel candidate cancer-related genes that are potentially involved in the evolution of BE to EAC...
  5. pmc Functional analysis of a novel DNA polymorphism of a tandem repeated sequence in the asparagine synthetase gene in acute lymphoblastic leukemia cells
    Tadayuki Akagi
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Leuk Res 33:991-6. 2009
    ..Clinical significance in ALL requires further studies...
  6. pmc Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype
    Tadayuki Akagi
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Haematologica 94:213-23. 2009
    ..Here, we identified hidden genomic alterations and novel disease-related regions in normal karyotype acute myeloid leukemia/myelodysplastic syndrome samples...
  7. pmc Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells
    Chuanhai Sun
    Department of Stem Cell Biology, Graduate School of Medical Science, Kanazawa University, Ishikawa 920 8640, Japan
    Mol Cell Biol 29:4574-83. 2009
    ..Furthermore, overexpression of Dax1 resulted in ES cell differentiation. Taken together, these data suggest that Dax1, a novel molecule interacting with Oct3/4, functions as a negative regulator of Oct3/4 in ES cells...
  8. pmc Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia
    Ryoko Okamoto
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, 8700, Beverly Blvd, Los Angeles, CA90048, USA
    Haematologica 95:1481-8. 2010
    ..The inferior prognosis in adult acute lymphoblastic leukemia is not fully understood but could be attributed, in part, to differences in genomic alterations found in adult as compared to in pediatric acute lymphoblastic leukemia...
  9. doi request reprint STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells
    Hiroki Ura
    Department of Stem Cell Biology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    J Biol Chem 283:9713-23. 2008
    ..These results suggest that STAT3 and Oct-3/4 maintain silencing of differentiation-associated genes through up-regulation of Eed in self-renewing ES cells...
  10. pmc Eed/Sox2 regulatory loop controls ES cell self-renewal through histone methylation and acetylation
    Hiroki Ura
    Department of Stem Cell Biology, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan
    EMBO J 30:2190-204. 2011
    ..Taken together, our results suggest that the Eed/Sox2 regulatory loop contributes to the maintenance of self-renewal in ES cells by controlling histone methylation and acetylation...
  11. doi request reprint Stem cell-specific expression of Dax1 is conferred by STAT3 and Oct3/4 in embryonic stem cells
    Chuanhai Sun
    Department of Stem Cell Biology, Graduate School of Medical Science, Kanazawa University, Ishikawa 920 8640, Japan
    Biochem Biophys Res Commun 372:91-6. 2008
    ..Furthermore, gel shift assay indicated that these transcription factors directly bind to their putative binding sites. These results suggest that STAT3 and Oct3/4 control the expression of Dax1 to maintain the self-renewal of ES cells...
  12. pmc Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomy
    Daniel Nowak
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Haematologica 94:518-27. 2009
    ....
  13. doi request reprint Novel Gemini vitamin D3 analogs: large structure/function analysis and ability to induce antimicrobial peptide
    Ryoko Okamoto
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA
    Int J Cancer 134:207-17. 2014
    ..This suggests a unique prophylactic treatment at diagnosis or during induction chemotherapy for AML patients to provide them with protection against various microbial infections through CAMP induction...
  14. pmc Dax1 associates with Esrrb and regulates its function in embryonic stem cells
    Kousuke Uranishi
    Department of Stem Cell Biology, Kanazawa University, Ishikawa, Japan
    Mol Cell Biol 33:2056-66. 2013
    ..These data, together with previous findings, suggest that Dax1 functions as a negative regulator of Esrrb and Oct3/4, and these molecules form a regulatory loop for controlling the pluripotency and self-renewal capacity of ES cells...
  15. ncbi request reprint GABPalpha regulates Oct-3/4 expression in mouse embryonic stem cells
    Keita Kinoshita
    Department of Stem Cell Biology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    Biochem Biophys Res Commun 353:686-91. 2007
    ..Moreover, the induction of Oct-3/4 repressors Cdx-2, Coup-tf1, and GCNF was stimulated by GABPalpha knockdown. These data suggest that GABPalpha upregulates the expression of Oct-3/4 via downregulation of Oct-3/4 repressors...
  16. pmc Epigenetic regulation and molecular characterization of C/EBPalpha in pancreatic cancer cells
    Takashi Kumagai
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA, USA
    Int J Cancer 124:827-33. 2009
    ....
  17. pmc Impaired response to GM-CSF and G-CSF, and enhanced apoptosis in C/EBPbeta-deficient hematopoietic cells
    Tadayuki Akagi
    Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, Los Angeles, CA 90048, USA
    Blood 111:2999-3004. 2008
    ..Our present results indicate that C/EBPbeta helps regulate survival of neutrophils, downstream of the granulocyte colony stimulating factor receptor...
  18. doi request reprint Zfp296 is a novel Klf4-interacting protein and functions as a negative regulator
    Yuka Fujii
    Department of Stem Cell Biology, Graduate School of Medical Sciences, Kanazawa University, Japan
    Biochem Biophys Res Commun 441:411-7. 2013
    ..In contrast, a reporter assay showed that the Lefty1 promoter was activated by Klf4, and that the enhanced activity was repressed by Zfp296. These findings suggest that Zfp296 is a functional regulator of Klf4 in ES cells. ..
  19. pmc Inecalcitol, an analog of 1α,25(OH)(2) D(3) , induces growth arrest of androgen-dependent prostate cancer cells
    Ryoko Okamoto
    UCLA School of Medicine, Los Angeles, CA, USA
    Int J Cancer 130:2464-73. 2012
    ....
  20. doi request reprint Vitamin D compounds and myelodysplastic syndrome
    Ryoko Okamoto
    Division of Hematology and Oncology, Cedar Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Leuk Lymphoma 49:12-3. 2008
  21. ncbi request reprint Identification of Zfp-57 as a downstream molecule of STAT3 and Oct-3/4 in embryonic stem cells
    Tadayuki Akagi
    Department of Stem Cell Biology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    Biochem Biophys Res Commun 331:23-30. 2005
    ..These data suggest that Zfp-57 is a downstream molecule of STAT3 and Oct-3/4 in ES cells, although dispensable for their self-renewal...