Akira Tsuburaya

Summary

Affiliation: Kanagawa Cancer Center
Country: Japan

Publications

  1. ncbi request reprint A randomized phase III trial of post-operative adjuvant oral fluoropyrimidine versus sequential paclitaxel/oral fluoropyrimidine; and UFT versus S1 for T3/T4 gastric carcinoma: the Stomach Cancer Adjuvant Multi-institutional Trial Group (Samit) Trial
    Akira Tsuburaya
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Asahi ku, Yokohama 2410815, Japan
    Jpn J Clin Oncol 35:672-5. 2005
  2. doi request reprint Phase II trial of paclitaxel and cisplatin as neoadjuvant chemotherapy for locally advanced gastric cancer
    Akira Tsuburaya
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2, Nakao, Asahi, Yokohama 2410815, Japan
    Cancer Chemother Pharmacol 71:1309-14. 2013
  3. pmc A randomized phase II trial to elucidate the efficacy of capecitabine plus cisplatin (XP) and S-1 plus cisplatin (SP) as a first-line treatment for advanced gastric cancer: XP ascertainment vs. SP randomized PII trial (XParTS II)
    Akira Tsuburaya
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, 241 0815, Yokohama, Asahi ku, Japan
    BMC Cancer 12:307. 2012
  4. ncbi request reprint Human epidermal growth factor receptor 2 (Her-2) and S-1 adjuvant chemotherapy in stage 2/3 gastric cancer patients who underwent D2 gastrectomy
    Toru Aoyama
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, 241 0815, Japan
    Surg Today 43:1390-7. 2013
  5. doi request reprint Body weight loss after surgery is an independent risk factor for continuation of S-1 adjuvant chemotherapy for gastric cancer
    Toru Aoyama
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, Japan
    Ann Surg Oncol 20:2000-6. 2013
  6. doi request reprint A prospective validation study to diagnose serosal invasion and nodal metastases of gastric cancer by multidetector-row CT
    Shinichi Hasegawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, 241 0815, Japan
    Ann Surg Oncol 20:2016-22. 2013
  7. ncbi request reprint Esophagus or stomach? The seventh TNM classification for Siewert type II/III junctional adenocarcinoma
    Shinichi Hasegawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, 241 0815, Japan
    Ann Surg Oncol 20:773-9. 2013
  8. doi request reprint Macroscopic tumor size as an independent prognostic factor for stage II/III gastric cancer patients who underwent D2 gastrectomy followed by adjuvant chemotherapy with S-1
    Toru Aoyama
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, 241 0815, Japan
    Gastric Cancer 14:274-8. 2011
  9. doi request reprint Pathological complete response of locally advanced gastric cancer after four courses of neoadjuvant chemotherapy with paclitaxel plus cisplatin: report of a case
    Takafumi Watanabe
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Yokohama, Asahi Ku 241 0815, Japan
    Surg Today 42:983-7. 2012
  10. ncbi request reprint [Case of stage IIB gastric cancer with positive margin treated with sequential therapy consisting of S-1, chemoradiation therapy with paclitaxel and CDDP, and S-1 after surgery]
    Toru Aoyama
    Dept of Gastrointestinal Surgery, Kanagawa Cancer Center, Japan
    Gan To Kagaku Ryoho 39:1892-4. 2012

Detail Information

Publications67

  1. ncbi request reprint A randomized phase III trial of post-operative adjuvant oral fluoropyrimidine versus sequential paclitaxel/oral fluoropyrimidine; and UFT versus S1 for T3/T4 gastric carcinoma: the Stomach Cancer Adjuvant Multi-institutional Trial Group (Samit) Trial
    Akira Tsuburaya
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Asahi ku, Yokohama 2410815, Japan
    Jpn J Clin Oncol 35:672-5. 2005
    ..This trial could appraise sequential combination therapy and efficacy of new drugs as adjuvant for gastric cancer treatment...
  2. doi request reprint Phase II trial of paclitaxel and cisplatin as neoadjuvant chemotherapy for locally advanced gastric cancer
    Akira Tsuburaya
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2, Nakao, Asahi, Yokohama 2410815, Japan
    Cancer Chemother Pharmacol 71:1309-14. 2013
    ..Paclitaxel-cisplatin (TC) combination is effective and well tolerated in patients with unresectable gastric cancer. We investigated the efficacy and safety of TC for locally advanced gastric cancers in a neoadjuvant setting...
  3. pmc A randomized phase II trial to elucidate the efficacy of capecitabine plus cisplatin (XP) and S-1 plus cisplatin (SP) as a first-line treatment for advanced gastric cancer: XP ascertainment vs. SP randomized PII trial (XParTS II)
    Akira Tsuburaya
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, 241 0815, Yokohama, Asahi ku, Japan
    BMC Cancer 12:307. 2012
    ..However, the usefulness of XP as compared with S-1 plus cisplatin (SP), which is considered standard therapy in Japan, has not yet been assessed...
  4. ncbi request reprint Human epidermal growth factor receptor 2 (Her-2) and S-1 adjuvant chemotherapy in stage 2/3 gastric cancer patients who underwent D2 gastrectomy
    Toru Aoyama
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, 241 0815, Japan
    Surg Today 43:1390-7. 2013
    ..However, there is currently no information available on the rate of Her-2 positivity and the relapse-free survival (RFS) stratified by Her-2 status in stage 2/3 patients...
  5. doi request reprint Body weight loss after surgery is an independent risk factor for continuation of S-1 adjuvant chemotherapy for gastric cancer
    Toru Aoyama
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, Japan
    Ann Surg Oncol 20:2000-6. 2013
    ..Compliance of S-1 adjuvant chemotherapy is not high. The aim of the present study is to clarify risk factors for continuation of S-1 after gastrectomy...
  6. doi request reprint A prospective validation study to diagnose serosal invasion and nodal metastases of gastric cancer by multidetector-row CT
    Shinichi Hasegawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, 241 0815, Japan
    Ann Surg Oncol 20:2016-22. 2013
    ..However, the standard methods and criteria to diagnose the T and N stages to select the patients who are good candidates for neoadjuvant chemotherapy have not been established yet...
  7. ncbi request reprint Esophagus or stomach? The seventh TNM classification for Siewert type II/III junctional adenocarcinoma
    Shinichi Hasegawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, 241 0815, Japan
    Ann Surg Oncol 20:773-9. 2013
    ..The aim of this study is to clarify whether TNM-EC or TNM-GC is better for classifying patients with AEG types II/III...
  8. doi request reprint Macroscopic tumor size as an independent prognostic factor for stage II/III gastric cancer patients who underwent D2 gastrectomy followed by adjuvant chemotherapy with S-1
    Toru Aoyama
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, 241 0815, Japan
    Gastric Cancer 14:274-8. 2011
    ..The objective of this retrospective study was to clarify the prognostic factors in these patients that might be useful for future patients...
  9. doi request reprint Pathological complete response of locally advanced gastric cancer after four courses of neoadjuvant chemotherapy with paclitaxel plus cisplatin: report of a case
    Takafumi Watanabe
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Yokohama, Asahi Ku 241 0815, Japan
    Surg Today 42:983-7. 2012
    ..On microscopic examinations, no tumor cells were detected in the ulcer scar of the resected stomach or the regional lymph nodes. Thus, we discuss the potential of long-term NAC, especially for responders to two initial courses...
  10. ncbi request reprint [Case of stage IIB gastric cancer with positive margin treated with sequential therapy consisting of S-1, chemoradiation therapy with paclitaxel and CDDP, and S-1 after surgery]
    Toru Aoyama
    Dept of Gastrointestinal Surgery, Kanagawa Cancer Center, Japan
    Gan To Kagaku Ryoho 39:1892-4. 2012
    ..To date, no recurrence has been observed 5 years after surgery. This sequential therapy is an option to consider for enabling local and systemic control after gastric cancer surgery...
  11. ncbi request reprint Is bursectomy necessary for patients with gastric cancer invading the serosa?
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center Hospital, Yokohama, Japan
    Hepatogastroenterology 51:1524-6. 2004
    ....
  12. ncbi request reprint Priority of lymph node dissection for Siewert type II/III adenocarcinoma of the esophagogastric junction
    Shinichi Hasegawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Ann Surg Oncol 20:4252-9. 2013
    ..The purpose of this study was to clarify the priority of nodal dissection in Siewert types II and III adenocarcinoma of the esophagogastric junction (AEG)...
  13. ncbi request reprint Effects of TS-1 on peritoneal dissemination of gastric cancer in nude mice
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Research Institute Kanagawa Cancer Center, Yokohama City Kowan Hospital, Yokohama, Japan
    Hepatogastroenterology 51:1554-7. 2004
    ..We investigated the effects of TS-1 on the survival of nude mice developing peritoneal dissemination of gastric cancer...
  14. ncbi request reprint A combination immunochemotherapy of 5-fluorouracil, cisplatin, leucovorin, and OK-432 for advanced and recurrent gastric carcinoma
    Takaki Yoshikawa
    Third Department of Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Hepatogastroenterology 50:2259-63. 2003
    ....
  15. doi request reprint Survival and prognosticators of gastric cancer that recurs after adjuvant chemotherapy with S-1
    Toru Aoyama
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Gastric Cancer 14:150-4. 2011
    ..Some patients experience a recurrence of cancer even after curative D2 gastrectomy followed by adjuvant S-1 chemotherapy. The objective of this retrospective study was to clarify the survival and prognosticators in these patients...
  16. ncbi request reprint Feasibility study of biweekly CPT-11 plus CDDP for S-1- and paclitaxel-refractory, metastatic gastric cancer
    Tatsuya Yoshida
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Anticancer Res 26:1595-8. 2006
    ....
  17. doi request reprint Risk factors for 6-month continuation of S-1 adjuvant chemotherapy for gastric cancer
    Toru Aoyama
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, 241 0815, Japan
    Gastric Cancer 16:133-9. 2013
    ..The objective of this retrospective study was to clarify the risk factors for 6-month continuation of S-1 adjuvant chemotherapy...
  18. doi request reprint A comparison of multimodality treatment: two or four courses of paclitaxel plus cisplatin or S-1 plus cisplatin followed by surgery for locally advanced gastric cancer, a randomized Phase II trial (COMPASS)
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Asahi ku, Yokohama, Japan
    Jpn J Clin Oncol 40:369-72. 2010
    ..This trial could appraise more suitable cycles and regimen as neoadjuvant chemotherapy for gastric cancer...
  19. ncbi request reprint Longterm control of advanced and recurrent gastric cancer (ARGC) by S-1
    Haruhiko Cho
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Gastric Cancer 6:24-7. 2003
    ..It has achieved a high response rate against advanced and recurrent gastric cancer (ARGC) in Japan; however, the efficacy and adverse reactions of longterm administration of S-1 remain to be elucidated...
  20. doi request reprint Laparoscopic or open distal gastrectomy after neoadjuvant chemotherapy for operable gastric cancer, a randomized Phase II trial (LANDSCOPE trial)
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Jpn J Clin Oncol 42:654-7. 2012
    ..This trial will be able to appraise the use of the laparoscopic approach as a curative D2 distal gastrectomy after neoadjuvant chemotherapy for gastric cancer...
  21. ncbi request reprint Expression of MMP-7 and MT1-MMP in peritoneal dissemination of gastric cancer
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama Kowan Hospital, Yokohama, Japan
    Hepatogastroenterology 53:964-7. 2006
    ....
  22. ncbi request reprint Clinical and pathological study of gastric cancer with ovarian metastasis
    Osamu Kobayashi
    The Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Int J Clin Oncol 8:67-71. 2003
    ..The aim of this study was to determine the treatment strategy for ovarian metastases from gastric cancer, by a retrospective study of the treatment results...
  23. doi request reprint Risk factors for peritoneal recurrence in stage II/III gastric cancer patients who received S-1 adjuvant chemotherapy after D2 gastrectomy
    Toru Aoyama
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Ann Surg Oncol 19:1568-74. 2012
    ..The objective of this retrospective study was to clarify the risk factors for peritoneal recurrence in patients who received S-1 adjuvant chemotherapy...
  24. doi request reprint A comparison of multimodality treatment: two and four courses of neoadjuvant chemotherapy using S-1/CDDP or S-1/CDDP/docetaxel followed by surgery and S-1 adjuvant chemotherapy for macroscopically resectable serosa-positive gastric cancer: a randomized ph
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama 241 0815, Japan
    Jpn J Clin Oncol 42:74-7. 2012
    ..This trial will be able to define the more suitable number of cycles and better regimen of neoadjuvant chemotherapy for gastric cancer...
  25. ncbi request reprint [A case of gastric small cell carcinoma with metastatic liver tumors responding to surgery and chemotherapy]
    Toru Aoyama
    Dept of Gastrointestinal Surgery, Kanagawa Cancer Center, Japan
    Gan To Kagaku Ryoho 39:1889-91. 2012
    ..The patient is alive 22 months after his operation. We conclude that the combination of surgery and chemotherapy was effective for small cell carcinoma of the stomach, which was considered to have a poor prognosis...
  26. doi request reprint Impact of plasma tissue inhibitor of metalloproteinase-1 on long-term survival in patients with gastric cancer
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, 241 0815, Japan
    Gastric Cancer 12:31-6. 2009
    ..The expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) is correlated with tumor invasion and metastases...
  27. doi request reprint A phase I study of palliative chemoradiation therapy with paclitaxel and cisplatin for local symptoms due to an unresectable primary advanced or locally recurrent gastric adenocarcinoma
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Cancer Chemother Pharmacol 64:1071-7. 2009
    ....
  28. ncbi request reprint Laparoscopic esophagojejunostomy using the EndoStitch and a circular stapler under a direct view created by the ENDOCAMELEON
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, 241 0815, Japan
    Gastric Cancer 16:609-14. 2013
    ..No case required conversion to open surgery. Neither anastomotic leakage nor stenosis was observed. This method is simple and useful for laparoscopic esophagojejunostomy after total gastrectomy for gastric cancer...
  29. doi request reprint A prospective feasibility and safety study of laparoscopy-assisted distal gastrectomy for clinical stage I gastric cancer initiated by surgeons with much experience of open gastrectomy and laparoscopic surgery
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, 241 0815, Japan
    Gastric Cancer 16:126-32. 2013
    ..The aim of this prospective study was to evaluate the feasibility and safety of laparoscopy-assisted distal gastrectomy (LADG) initiated by surgeons with much experience of open gastrectomy and laparoscopic surgery...
  30. ncbi request reprint Should gastric cancer with peritoneal metastasis be treated surgically?
    Takaki Yoshikawa
    Division of Gastric Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Hepatogastroenterology 50:1712-5. 2003
    ..This study was attempted to elucidate the role of surgery in patients with gastric carcinoma and peritoneal dissemination...
  31. ncbi request reprint The efficacy of gastrectomy for large gastric cancer
    Osamu Kobayashi
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Yokohama, 241 0815, Japan
    Int J Clin Oncol 11:44-50. 2006
    ..Large gastric cancer (LGC) is frequently associated with extended disease, and the role of surgical resection has been debated. We investigated the efficacy of surgical treatment for LGC...
  32. ncbi request reprint Unusual survival for more than 2 years with peritoneal metastases of gastric cancer
    Osamu Kobayashi
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Gastric Cancer 5:47-50. 2002
    ..Our report is the first to demonstrate the advantages of TS-1 as chemotherapy for the treatment of peritoneal metastasis of gastric cancer...
  33. doi request reprint A Phase III trial to evaluate the effect of perioperative nutrition enriched with eicosapentaenoic acid on body weight loss after total gastrectomy for T2-T4a gastric cancer
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Jpn J Clin Oncol 42:459-62. 2012
    ....
  34. doi request reprint Safety and feasibility of S-1 adjuvant chemotherapy for gastric cancer in elderly patients
    Toru Aoyama
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, Japan
    Gastric Cancer 15:76-82. 2012
    ..The safety and feasibility of administering S-1 adjuvant chemotherapy for gastric cancer has not been fully evaluated in elderly patients...
  35. ncbi request reprint Solitary metastasis to the left axillary lymph node after curative gastrectomy in gastric cancer
    Osamu Kobayashi
    The Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Gastric Cancer 5:173-6. 2002
    ..One year after the reoperation, she has had no recurrence. We conclude that gastric cancer can metastasize to unusual sites. A re-radical resection is recommended if curative resection is feasible...
  36. ncbi request reprint [Postoperative anastomotic hemorrhage after gastrectomy]
    Toru Aoyama
    Dept of Gastrointestinal Surgery, Kanagawa Cancer Center, Japan
    Gan To Kagaku Ryoho 39:2298-300. 2012
    ..Postoperative anastomotic hemorrhage is a relatively rare complication. However, when it does occur, immediate treatment is needed...
  37. ncbi request reprint [Neoadjuvant chemotherapy for gastric cancer--evidence from the world and future strategy in Japan]
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Kanagawa, Japan
    Gan To Kagaku Ryoho 39:866-70. 2012
    ..In another group, two randomized Phase II trials are also ongoing to compare different regimens and courses of neoadjuvant chemotherapy. These studies will set the direction of neoadjuvant chemotherapy development in the future...
  38. ncbi request reprint Protein levels of tissue inhibitor of metalloproteinase-1 in tumor extracts as a marker for prognosis and recurrence in patients with gastric cancer
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Gastric Cancer 9:106-13. 2006
    ..Tissue inhibitor of metalloproteinase-1 (TIMP-1) correlates with tumor progression in patients with gastric cancer; however, the clinical significance of TIMP-1 as a marker for prognosis and recurrence has not been fully clarified...
  39. ncbi request reprint [Comparison of body weight loss in gastrectomy patients who underwent only surgery and those who underwent surgery followed up with S-1 adjuvant chemotherapy]
    Toru Aoyama
    Dept of Gastrointestinal Surgery, Kanagawa Cancer Center, Japan
    Gan To Kagaku Ryoho 39:1794-6. 2012
    ..Body weight loss is a common outcome in patients with gastric cancer who have undergone gastrectomy. However, the rate of body weight loss after surgery is unknown...
  40. doi request reprint Severity of complications after gastrectomy in elderly patients with gastric cancer
    Tsutomu Hayashi
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    World J Surg 36:2139-45. 2012
    ..The risk of surgery for gastric cancer has not been fully evaluated, and this study aimed to assess the severity of postoperative complications after D2 or modified D2 gastrectomy in elderly patients...
  41. doi request reprint Is adenocarcinoma of the esophagogastric junction different between Japan and western countries? The incidence and clinicopathological features at a Japanese high-volume cancer center
    Shinichi Hasegawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 241 0815 Nakao 1 1 2, Asahi ku, Yokohama City, Japan
    World J Surg 33:95-103. 2009
    ..We clarified the incidence of adenocarcinoma of the esophagogastric junction (AEG) at a Japanese high-volume cancer center and its clinicopathological features between the Siewert subtypes...
  42. ncbi request reprint Indications of limited surgery for gastric cancer with submucosal invasion--analysis of 715 cases with special reference to site of the tumor and level 2 lymph nodes
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center Hospital, Yokohama, Japan
    Hepatogastroenterology 50:1727-30. 2003
    ..There is controversy as to whether limited or extended lymph node dissection should be performed for gastric cancer with submucosal invasion...
  43. ncbi request reprint Clinical diagnosis of metastatic gastric tumors: clinicopathologic findings and prognosis of nine patients in a single cancer center
    Osamu Kobayashi
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, 241 0815 Yokohama, Japan
    World J Surg 28:548-51. 2004
    ..Because multiple metastases are common, the prognosis of MGT is poor even after curative resection. MGT is likely to be a preterminal event, and surgical resection may be useful only for palliation...
  44. doi request reprint Small bud of probable gastrointestinal stromal tumor within a laparoscopically-resected gastric schwannoma
    Haruhiko Cho
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center Hospital, 1 1 2 Nakao, Asahi ku, Yokohama, 241 0815, Japan
    Int J Clin Oncol 17:294-8. 2012
    ..Our observations raised the significance of genotyping for diagnosis of GI tract SMTs...
  45. pmc Methylene blue-assisted technique for harvesting lymph nodes after radical surgery for gastric cancer: a prospective randomized phase III study
    Toru Aoyama
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    BMC Cancer 14:155. 2014
    ..This randomized Phase III trial will evaluate whether the methylene blue-assisted technique is efficient for harvesting lymph nodes after radical surgery for gastric cancer...
  46. ncbi request reprint Matched pair analysis to examine the effects of a planned preoperative exercise program in early gastric cancer patients with metabolic syndrome to reduce operative risk: the Adjuvant Exercise for General Elective Surgery (AEGES) study group
    Haruhiko Cho
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Ann Surg Oncol 21:2044-50. 2014
    ....
  47. pmc Laparoscopy-assisted distal gastrectomy for an early gastric cancer patient with situs inversus totalis
    Hirohito Fujikawa
    1 Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Int Surg 98:266-70. 2013
    ..The operating time was 234 minutes and blood loss was 5 mL. Although a mechanical obstruction occurred after surgery, the patient recovered after re-operation with Roux-en-Y bypass...
  48. doi request reprint A phase II study of doxifluridine and docetaxel combination chemotherapy for advanced or recurrent gastric cancer
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Gastric Cancer 12:212-8. 2009
    ..The aim of this study was to establish the efficacy and safety of doxifluridine and docetaxel for patients with advanced or recurrent gastric cancer...
  49. ncbi request reprint Metastatic gastrointestinal stromal tumor with an exon 11 c-kit mutation responding to the tyrosine kinase inhibitor imatinib
    Haruhiko Cho
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Dig Surg 21:74-7. 2004
  50. ncbi request reprint Induction of lymphokine-activated cytotoxic T lymphocytes stimulated by dendritic cells and autologous tumor from a patient with gastric cancer and their effects in vitro
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Hepatogastroenterology 52:289-92. 2005
    ..The purpose of the study was to generate lymphokine-activated cytotoxic T lymphocytes stimulated by dendritic cells (DC) and autologous tumor from a patient with gastric cancer and to clarify their cytotoxic effects in vitro...
  51. ncbi request reprint Peritoneal cytology in patients with gastric cancer exposed to the serosa--a proposed new classification based on the local and distant cytology
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Hepatogastroenterology 50:1183-6. 2003
    ..The clinical impact of the cytology of intraperitoneal samples taken from the local and distant sites was examined in patients with gastric carcinoma...
  52. ncbi request reprint Accuracy of CT staging of locally advanced gastric cancer after neoadjuvant chemotherapy: cohort evaluation within a randomized phase II study
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Ann Surg Oncol 21:S385-9. 2014
    ..Accuracy of the radiologic diagnosis of gastric cancer staging after neoadjuvant chemotherapy remains unclear...
  53. ncbi request reprint An anti-apoptosis gene, survivin and telomerase expression in gastric cancer
    Akira Tsuburaya
    Department of Surgery, Kanagawa Cancer Center, School of Medicine, Yokohama City University, Japan
    Hepatogastroenterology 49:1150-2. 2002
    ..To test this hypothesis, we investigated the expression of survivin and telomerase in stomach cancer...
  54. doi request reprint Indications for staging laparoscopy in clinical T4M0 gastric cancer
    Kazuhito Tsuchida
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, 241 0815, Japan
    World J Surg 35:2703-9. 2011
    ..This study was undertaken to determine the efficacy of the clinical indications for performing staging laparoscopy for locally advanced gastric cancer to detect peritoneal metastasis or positive cytology findings...
  55. ncbi request reprint Solitary lymph node metastasis of gastric cancer as a basis for sentinel lymph node biopsy
    Akira Tsuburaya
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2, Nakao, Asahi ku, Yokohama 2410815, Japan
    Hepatogastroenterology 49:1449-52. 2002
    ..In order to examine the biology of sentinel lymph node of stomach cancer, we investigated solitary lymph node metastases that were hypothesized to represent sentinel lymph node...
  56. ncbi request reprint Up-regulation of hypoxia-inducible factor-1 alpha and VEGF mRNAs in peritoneal dissemination of patients with gastric cancer
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Anticancer Res 26:3849-53. 2006
    ..Hypoxia-inducible factor-1 (HIF-1) and its target gene, vascular endothelial growth factor (VEGF), may play a role in the development of peritoneal metastases...
  57. ncbi request reprint Inhibition of peritoneal metastasis in an animal gastric cancer model by interferon-gamma and interleukin-2
    Takahide Okamoto
    First Department of Surgery, Yokohama City University, School of Medicine, Kanazawa Ku, Yokohama, Japan
    Anticancer Res 23:149-53. 2003
    ..The anti-tumor activity of interferon-gamma (IFN-gamma) and interleukin-2 (IL-2) have been shown in human gastric cancer cell lines, however, their therapeutic effects on peritoneal metastasis have not been investigated...
  58. doi request reprint The superiority of the seventh edition of the TNM classification depends on the overall survival of the patient cohort: comparative analysis of the sixth and seventh TNM editions in patients with gastric cancer from Japan and the United Kingdom
    Tsutomu Hayashi
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Cancer 119:1330-7. 2013
    ....
  59. doi request reprint Usefulness of enhanced recovery after surgery protocol as compared with conventional perioperative care in gastric surgery
    Takanobu Yamada
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, Kanagawa, Japan
    Gastric Cancer 15:34-41. 2012
    ..The aim of this study was to assess the usefulness of an ERAS protocol for gastric surgery...
  60. ncbi request reprint Sequential paclitaxel followed by tegafur and uracil (UFT) or S-1 versus UFT or S-1 monotherapy as adjuvant chemotherapy for T4a/b gastric cancer (SAMIT): a phase 3 factorial randomised controlled trial
    Akira Tsuburaya
    Yokohama City University, Yokohama, Japan
    Lancet Oncol 15:886-93. 2014
    ....
  61. doi request reprint A randomized phase II trial of preoperative exercise to reduce operative risk in gastric cancer patients with metabolic syndrome: adjuvant exercise for general elective surgery (AEGES) study group
    Haruhiko Cho
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2, Nakao, Asahi ku, Yokohama 2410815, Japan
    Jpn J Clin Oncol 38:71-3. 2008
    ..The sample size is 86 (43 for surgery alone and 43 for exercise group) to select promising treatment for Phase III trial in a randomized Phase II setting...
  62. ncbi request reprint Neoadjuvant chemotherapy for gastric cancer in Japan: a standing position by comparing with adjuvant chemotherapy
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama, 241 0815, Japan
    Surg Today 44:11-21. 2014
    ..The optimal courses and regimens of neoadjuvant chemotherapy should, therefore, be clarified in the future. ..
  63. ncbi request reprint [Evidence and issues in standardization of intraperitoneal chemotherapy]
    Akira Tsuburaya
    Gastrointestinal Surgery, Kanagawa Cancer Center, Asahi ku, Yokohama, Japan
    Gan To Kagaku Ryoho 35:881-4. 2008
    ..p. regimen. In gastric cancer, the advantage of i.p. therapy has not been proved, and for its approval, phase I-III trial of i.p. with or without cytoreduction surgery should be initiated...
  64. ncbi request reprint Is D2 lymph node dissection necessary for early gastric cancer?
    Takaki Yoshikawa
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center Hospital, Yokohama, Japan
    Ann Surg Oncol 9:401-5. 2002
    ..The objective of this study was to clarify a survival benefit of D2 lymphadenectomy in patients with early gastric carcinoma (GC)...
  65. ncbi request reprint [Points of revision in the new Japanese treatment guidelines for gastric cancer]
    Akira Tsuburaya
    Gastrointestinal Surgery, Kanagawa Cancer Center, Japan
    Nihon Rinsho 70:1758-62. 2012
    ..The major revision points are summarized in this paper...
  66. ncbi request reprint [Current status of treatment for elderly patients with gastric cancer]
    Akira Tsuburaya
    Department of Gastro intestinal Surgery, Kanagawa Cancer Center, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Gan To Kagaku Ryoho 37:2817-22. 2010
    ....
  67. ncbi request reprint [Adjuvant therapy for advanced gastric cancer]
    Akira Tsuburaya
    Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
    Nihon Geka Gakkai Zasshi 113:8-11. 2012
    ..Other issues include the role of surgery in local control with regard to adjuvant treatment such as radiation and molecular-targeted treatment to establish a worldwide standard...