Research Topics
Genomes and Genes | Yuko Mimori-KiyosueSummaryAffiliation: KAN Research Institute Country: Japan Publications
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Detail Information
Publications
CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortexYuko Mimori-Kiyosue
KAN Research Institute, Kyoto Research Park, Shimogyo ku, Kyoto 600 8815, Japan
J Cell Biol 168:141-53. 2005..We propose that CLASPs can mediate interactions between MT plus ends and the cell cortex and act as local rescue factors, possibly through forming a complex with EB1 at MT tips...
Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignmentYuko Mimori-Kiyosue
KAN Research Institute, Kyoto Research Park, Kyoto 600 8815, Japan
Genes Cells 11:845-57. 2006..This local stabilization of microtubules is essential for the formation of normal metaphase spindle, completion of anaphase and cytokinesis...
Adenomatous polyposis coli (APC) protein regulates epithelial cell migration and morphogenesis via PDZ domain-based interactions with plasma membranesYuko Mimori-Kiyosue
KAN Research Institute, Kyoto Research Park, Kyoto 600 8815, Japan
Genes Cells 12:219-33. 2007..These results suggest that APC links MTs to plasma membranes through interactions with PDZ proteins, such that the migration and morphogenesis of epithelial cells can be properly regulated...
[Microtubule plus-end-binding proteins (+TIPs)]Yuko Mimori-Kiyosue
Tanpakushitsu Kakusan Koso 51:543-50. 2006
Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/betaAzusa Hotta
KAN Research Institute, Inc, Chuo Ku, Kobe 650 0047, Japan
J Cell Biol 189:901-17. 2010..These findings reveal that signaling from laminin-integrin associations attaches microtubule plus ends to the epithelial basal cell cortex...
"Search-and-capture" of microtubules through plus-end-binding proteins (+TIPs)Yuko Mimori-Kiyosue
KAN Research Institute, Kyoto Research Park, Science Center Build 3, 93 Chudoji Awata cho, Shimogyo ku, Kyoto 600 8815
J Biochem 134:321-6. 2003....
Dynamic behavior of paired claudin strands within apposing plasma membranesHiroyuki Sasaki
KAN Research Institute Inc, Kyoto Research Park, Chudoji, Shimogyo ku, Kyoto 600 8317, Japan
Proc Natl Acad Sci U S A 100:3971-6. 2003....
Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEFChiyuki Matsui
KAN Research Institute, Inc, Kobe MI R and D Center, Chuo Ku, Kobe, 650 0047, Japan
J Biol Chem 283:33006-20. 2008..Our findings reveal that the SAMP motif of APC specifically binds to the SH3 domains of DDEFs, providing new insights into the functions of APC in cell migration...
CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5betaGideon Lansbergen
MGC Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
Dev Cell 11:21-32. 2006..We propose that LL5beta and ELKS can form a PIP3-regulated cortical platform to which CLASPs attach distal microtubule ends...
LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dyneinMasami Yamada
Department of Genetic Disease Research, Osaka City University Graduate School of Medicine, Osaka, Japan
EMBO J 27:2471-83. 2008....
Splicing factor SF3b as a target of the antitumor natural product pladienolideYoshihiko Kotake
Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3 Tokodai, Tsukuba, Ibaraki 300 2635, Japan
Nat Chem Biol 3:570-5. 2007..Our results demonstrate that the SF3b complex is a pharmacologically relevant protein target of pladienolide and suggest that this splicing factor is a potential antitumor drug target...
