Yasuto Uchikado

Summary

Affiliation: Kagoshima University
Country: Japan

Publications

  1. pmc Multicenter, phase II clinical trial of cancer vaccination for advanced esophageal cancer with three peptides derived from novel cancer-testis antigens
    Koji Kono
    First Department of Surgery, University of Yamanashi, Yamanashi, Japan
    J Transl Med 10:141. 2012
  2. ncbi request reprint Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma
    Yasuto Uchikado
    Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Clin Cancer Res 11:1174-80. 2005
  3. doi request reprint Increased Slug and decreased E-cadherin expression is related to poor prognosis in patients with gastric cancer
    Yasuto Uchikado
    Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, Kagoshima, 890 8520, Japan
    Gastric Cancer 14:41-9. 2011
  4. pmc Prognostic impact of CD168 expression in gastric cancer
    Sumiya Ishigami
    Digestive Surgery Surgical Oncology, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka Kagoshima 890 8520, Japan
    BMC Cancer 11:106. 2011
  5. doi request reprint Salvage gastrectomy following a combination of biweekly paclitaxel and S-1 for stage IV gastric cancer
    Sumiya Ishigami
    Digestive Surgery, Surgical Oncology, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima, 890, Japan
    J Gastrointest Surg 12:1370-5. 2008
  6. pmc Clinicopathological significance of BMP7 expression in esophageal squamous cell carcinoma
    Koichi Megumi
    Department of Surgical Oncology, Digestive Surgery, Kagoshima University, Graduate School of Medicine, Kagoshima, Japan
    Ann Surg Oncol 19:2066-71. 2012
  7. ncbi request reprint Carcinoembryonic antigen messenger RNA expression in blood can predict relapse in gastric cancer
    Sumiya Ishigami
    Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
    J Surg Res 148:205-9. 2008
  8. ncbi request reprint Expression of CXCL12 and its receptor CXCR4 in esophageal squamous cell carcinoma
    Ken Sasaki
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890 8520, Japan
    Oncol Rep 21:65-71. 2009
  9. pmc Significance of Twist expression and its association with E-cadherin in esophageal squamous cell carcinoma
    Ken Sasaki
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
    J Exp Clin Cancer Res 28:158. 2009
  10. ncbi request reprint Improvement in radiosensitivity using small interfering RNA targeting p53R2 in esophageal squamous cell carcinoma
    Naoya Yokomakura
    Department of Surgical Oncology and Digestive Surgery, Graduate School of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    Oncol Rep 18:561-7. 2007

Collaborators

Detail Information

Publications38

  1. pmc Multicenter, phase II clinical trial of cancer vaccination for advanced esophageal cancer with three peptides derived from novel cancer-testis antigens
    Koji Kono
    First Department of Surgery, University of Yamanashi, Yamanashi, Japan
    J Transl Med 10:141. 2012
    ....
  2. ncbi request reprint Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma
    Yasuto Uchikado
    Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Clin Cancer Res 11:1174-80. 2005
    ..The purpose of the present study was to evaluate the clinical significance of E-cadherin and Slug expression in ESCC...
  3. doi request reprint Increased Slug and decreased E-cadherin expression is related to poor prognosis in patients with gastric cancer
    Yasuto Uchikado
    Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, Kagoshima, 890 8520, Japan
    Gastric Cancer 14:41-9. 2011
    ..The purpose of the present study was to evaluate the clinical significance of E-cadherin and Slug expression in gastric cancer...
  4. pmc Prognostic impact of CD168 expression in gastric cancer
    Sumiya Ishigami
    Digestive Surgery Surgical Oncology, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka Kagoshima 890 8520, Japan
    BMC Cancer 11:106. 2011
    ..Cancerous CD168 expression is correlated with aggressive biological features in several cancers. However, the clinical implications of CD168 positivity in gastric cancer have remained unclear...
  5. doi request reprint Salvage gastrectomy following a combination of biweekly paclitaxel and S-1 for stage IV gastric cancer
    Sumiya Ishigami
    Digestive Surgery, Surgical Oncology, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima, 890, Japan
    J Gastrointest Surg 12:1370-5. 2008
    ..We investigated the clinical benefits of salvage gastrectomy for stage IV gastric cancer patients whose distant lesions showed complete response after chemotherapy...
  6. pmc Clinicopathological significance of BMP7 expression in esophageal squamous cell carcinoma
    Koichi Megumi
    Department of Surgical Oncology, Digestive Surgery, Kagoshima University, Graduate School of Medicine, Kagoshima, Japan
    Ann Surg Oncol 19:2066-71. 2012
    ..The purpose of the current study was to examine the expression of BMP7 in esophageal squamous cell carcinoma and to clarify the clinical impact of BMP7 expression in esophageal squamous cell carcinoma (ESCC)...
  7. ncbi request reprint Carcinoembryonic antigen messenger RNA expression in blood can predict relapse in gastric cancer
    Sumiya Ishigami
    Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
    J Surg Res 148:205-9. 2008
    ..To clarify the clinical implications of intraoperative carcinoembryonic antigen (CEA) mRNA copy number in peripheral blood samples from gastric cancer patients...
  8. ncbi request reprint Expression of CXCL12 and its receptor CXCR4 in esophageal squamous cell carcinoma
    Ken Sasaki
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890 8520, Japan
    Oncol Rep 21:65-71. 2009
    ..Evaluation of CXCL12 expression is useful for determining tumor properties, including nodal metastasis and prognosis in patients with ESCC...
  9. pmc Significance of Twist expression and its association with E-cadherin in esophageal squamous cell carcinoma
    Ken Sasaki
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
    J Exp Clin Cancer Res 28:158. 2009
    ..The purpose of this study is to evaluate the clinical significance of Twist and E-cadherin expression in ESCC...
  10. ncbi request reprint Improvement in radiosensitivity using small interfering RNA targeting p53R2 in esophageal squamous cell carcinoma
    Naoya Yokomakura
    Department of Surgical Oncology and Digestive Surgery, Graduate School of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    Oncol Rep 18:561-7. 2007
    ..This protocol could potentially improve the efficacy of radiation therapy...
  11. ncbi request reprint Overexpression of vascular endothelial growth factor-C correlates with lymph node micrometastasis in submucosal esophageal cancer
    Masataka Matsumoto
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Gastrointest Surg 10:1016-22. 2006
    ..0001 and P < 0.01, respectively). The present findings indicate that in ESCC with submucosal invasion, VEGF-C overexpression of the primary tumor is a strong high risk factor for lymph node metastasis, including LMM...
  12. doi request reprint Sentinel node navigation surgery is acceptable for clinical T1 and N0 esophageal cancer
    Yoshikazu Uenosono
    Department of Surgical Oncology and Digestive Surgery, Kagoshima University, Kagoshima, Japan
    Ann Surg Oncol 18:2003-9. 2011
    ..Our objective was to perform SN mapping in esophageal cancer to assess distribution of lymph node metastases with the goal to reduce the need for extensive lymphadenectomy...
  13. ncbi request reprint Expression of p53R2 is related to prognosis in patients with esophageal squamous cell carcinoma
    Hiroshi Okumura
    Department of Surgical Oncology and Digestive Surgery, Graduate School of Medicine, Kagoshima University, Sakuragaoka, Kagoshima, Japan
    Clin Cancer Res 12:3740-5. 2006
    ..In the present study, we analyzed the expression and clinicopathologic significance of p53 and p53R2 in esophageal squamous cell carcinoma...
  14. doi request reprint Clinical implications of N-cadherin expression in gastric cancer
    Takahito Kamikihara
    Digestive Surgery, Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan
    Pathol Int 62:161-6. 2012
    ..However, neo N-cadherin expression significantly affected patient's survival in gastric cancer. Therefore, we concluded that neo N-cadherin expression may be a useful prognostic marker independent of E-cadherin expression...
  15. ncbi request reprint Snail plays a key role in E-cadherin-preserved esophageal squamous cell carcinoma
    Shoji Natsugoe
    Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    Oncol Rep 17:517-23. 2007
    ..035). Snail appears to play a key role in preserved E-cadherin expression. Further studies on other molecules in the pathways related to reduced E-cadherin expression in ESCC from the view-point of EMT are necessary...
  16. ncbi request reprint alpha-catenin is a significant prognostic factor than E-cadherin in esophageal squamous cell carcinoma
    Tetsuro Setoyama
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University, Graduate School of Medical and Dental Science, Sakuragaoka, Kagoshima, Japan
    J Surg Oncol 95:148-55. 2007
    ..The purpose of the present study was to analyze clinicopathologic variables in esophageal squamous cell carcinoma (ESCC) according to expression of E-cadherin and alpha-catenin which play an important role in cell adhesion...
  17. doi request reprint Expression of CXCL12 and its receptor CXCR4 correlates with lymph node metastasis in submucosal esophageal cancer
    Ken Sasaki
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Surg Oncol 97:433-8. 2008
    ..We examined their expression and microvessel density (MVD) in submucosal esophageal squamous cell carcinoma (ESCC) and analyzed their connection to clinicopathological findings including lymph node micrometastasis (LMM)...
  18. ncbi request reprint Nuclear expression of 14-3-3 sigma is related to prognosis in patients with esophageal squamous cell carcinoma
    Hiroshi Okumura
    Department of Surgical Oncology, Graduate School of Medicine, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Anticancer Res 30:5175-9. 2010
    ..The 14-3-3 sigma gene is transcriptionally activated by p53 after DNA damage and facilitates DNA repair during G2 arrest. The present study analyzed the clinical significance of 14-3-3 sigma expression in esophageal squamous cell carcinoma...
  19. ncbi request reprint Clinical implication of CXCL12 expression in gastric cancer
    Sumiya Ishigami
    Digestive Surgery Surgical Oncology, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    Ann Surg Oncol 14:3154-8. 2007
    ..This study immunohistochemically investigated CXCL12 expression in gastric cancer and evaluated its association with clinical factors, including patient prognosis...
  20. doi request reprint Clinical implication of CD166 expression in gastric cancer
    Sumiya Ishigami
    Digestive Surgery, Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan
    J Surg Oncol 103:57-61. 2011
    ..Its expression is associated with aggressive tumor behavior. CD166 expression is a prognostic marker in several cancers, but the predictive value of CD166 expression in gastric cancer has not been clarified yet...
  21. ncbi request reprint Cancerous HLA class I expression and regulatory T cell infiltration in gastric cancer
    Sumiya Ishigami
    Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Cancer Immunol Immunother 61:1663-9. 2012
    ..In the current study, we investigated HLA class I expression and Treg cells infiltration in gastric cancer and discussed the clinical implications of this combinatory analysis in gastric cancer...
  22. ncbi request reprint [Neoadjuvant chemoradiotherapy for advanced esophageal cancer]
    Shoji Natsugoe
    Department of Surgical Oncology and Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Nihon Geka Gakkai Zasshi 112:111-6. 2011
    ..The effectiveness of CRT followed by surgery should be clarified based on excellent Japanese surgical techniques...
  23. ncbi request reprint [A case of successful treatment by low-dose 5-fluorouracil and cisplatin for liver metastases of esophageal adenosquamous carcinoma]
    Yasuto Uchikado
    Dept of Surgical Oncology, Graduate School of Medicine, Kagoshima University
    Gan To Kagaku Ryoho 33:83-5. 2006
    ..After 6 courses of chemotherapy, no liver metastases were detected. Based on the present findings, we recommend low-dose 5-fluorouracil/cisplatin therapy for liver metastasis from esophageal adenosquamous carcinoma...
  24. doi request reprint Clinical course and outcome after esophagectomy with three-field lymphadenectomy in esophageal cancer
    Shoji Natsugoe
    Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    Langenbecks Arch Surg 395:341-6. 2010
    ..Esophagectomy with three-field lymphadenectomy has been performed for esophageal cancer. Detailed analysis of cause of death and mode of recurrence is required to determine the need for further adjuvant therapy and follow-up...
  25. ncbi request reprint Prognostic impact of CD133 expression in gastric carcinoma
    Sumiya Ishigami
    Digestive Surgery, Surgical Oncology, Kagoshima University School of Medicine 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Anticancer Res 30:2453-7. 2010
    ..CD133 expression was evaluated in gastric cancer and the clinical impact of CD133-positive gastric cancer was clarified...
  26. ncbi request reprint Carcinoembryonic antigen messenger RNA expression in blood predicts recurrence in esophageal cancer
    Tetsuro Setoyama
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University, Graduate School of Medical and Dental Science, Kagoshima, Japan
    Clin Cancer Res 12:5972-7. 2006
    ..We conducted a longitudinal analysis of the relationship between ITC in blood during follow-up and clinicopathologic findings in patients with esophageal squamous cell carcinoma...
  27. ncbi request reprint Usefulness of sentinel node biopsy in laparoscopic partial gastrectomy for early gastric cancer
    Sumiya Ishigami
    Surgical Oncology, Digestive Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890, Japan
    Hepatogastroenterology 54:2164-6. 2007
    ..Five patients having early gastric cancer were treated using laparoscopic partial gastrectomy combined with sentinel lymph node biopsy...
  28. doi request reprint HLA-class I expression in gastric cancer
    Sumiya Ishigami
    Digestive Surgery Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan
    J Surg Oncol 97:605-8. 2008
    ..We investigated the clinical impact of HLA-class I tumor cells in gastric cancer...
  29. pmc Clinical implications of DLL4 expression in gastric cancer
    Sumiya Ishigami
    Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University School of Medicine, Sakuragaoka, Kagoshima 890 8520, Japan
    J Exp Clin Cancer Res 32:46. 2013
    ..Delta-like ligand 4 (DLL4)-Notch signaling plays a key role in tumor neovascular development and angiogenesis during tumor growth. The clinical significance of DLL4 expression in gastric cancer has not been clarified...
  30. ncbi request reprint Roux-en-Y reconstruction with stapled distal jejunal pouch after total gastrectomy
    Sumiya Ishigami
    Digestive Surgery and Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan
    Am Surg 76:526-8. 2010
    ..This procedure may improve postoperative malnutrition after total gastrectomy according to our feasible study. A multicenter randomized trial of this approach comparing with Roux-en-Y reconstruction without a pouch is ongoing...
  31. doi request reprint Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy
    Hiroshi Okumura
    Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical Sciences, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima, 890 8520, Japan
    Int J Clin Oncol 18:329-34. 2013
    ..In this study, we examined the histological prognostic factors for ESCC patients treated with CRT and determined an appropriate strategy for their evaluation...
  32. doi request reprint Feasibility of sentinel node navigation surgery after noncurative endoscopic resection for early gastric cancer
    Takaaki Arigami
    Department of Digestive Surgery, Breast and Thyroid Surgery, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Gastroenterol Hepatol 28:1343-7. 2013
    ..Here, we assessed the feasibility of SNNS after noncurative endoscopic resection for early gastric cancer...
  33. doi request reprint IL-32 expression is an independent prognostic marker for gastric cancer
    Sumiya Ishigami
    Digestive Surgery Surgical Oncology, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Med Oncol 30:472. 2013
    ..Pro-inflammatory cytokines induce immunosuppression in a paracrine manner, thereby facilitating the metastasis of tumor cells...
  34. doi request reprint Assessment of sentinel node concept in esophageal cancer based on lymph node micrometastasis
    Takahiko Hagihara
    Department of Digestive Surgery, Breast and Thyroid Surgery, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Ann Surg Oncol 20:3031-7. 2013
    ....
  35. doi request reprint Clinical significance of ¹⁸F-fluorodeoxyglucose positron emission tomography in superficial esophageal squamous cell carcinoma
    Yoshiaki Kita
    Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medicine, Kagoshima University, Sakuragaoka, Kagoshima, Japan
    Ann Surg Oncol 20:1646-52. 2013
    ..To assess the clinical usefulness and significance of (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in superficial esophageal squamous cell carcinoma (ESCC)...
  36. ncbi request reprint Predictive value of p53 and 14-3-3sigma for the effect of chemoradiation therapy on esophageal squamous cell carcinoma
    Hiroshi Okumura
    Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, Kagoshima, Japan
    J Surg Oncol 91:84-9. 2005
    ....
  37. ncbi request reprint Gene expression profiling of lymph node metastasis by oligomicroarray analysis using laser microdissection in esophageal squamous cell carcinoma
    Yasuto Uchikado
    Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    Int J Oncol 29:1337-47. 2006
    ..Although we were able to extract some genes related to nodal metastasis in ESCC, further examination is necessary in other genes as well as the interaction of stromal tissues...
  38. ncbi request reprint A phase I combination chemotherapy study of biweekly paclitaxel and S-1 administration in patients with advanced gastric cancer
    Shuichi Hokita
    First Department of Surgery School of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 8900075, Japan
    Cancer Chemother Pharmacol 57:736-40. 2006
    ..Biweekly paclitaxel/S-1 combination chemotherapy could be safely used for the treatment of advanced gastric cancer. The recommended doses for a phase II study with paclitaxel and S-1 are 120 mg/m2 and 80 mg/m2, respectively...