Shoji Natsugoe


Affiliation: Kagoshima University
Country: Japan


  1. Khalid M, Idichi T, Seki N, Wada M, Yamada Y, Fukuhisa H, et al. Gene Regulation by Antitumor miR-204-5p in Pancreatic Ductal Adenocarcinoma: The Clinical Significance of Direct RACGAP1 Regulation. Cancers (Basel). 2019;11: pubmed publisher
    ..g., MMP28, CEP55, CDK1, ANLN and S100A14) are involved in PDAC pathogenesis. Our strategy to identify antitumor miRNAs and their target genes will help elucidate the molecular pathogenesis of PDAC. ..
  2. Kijima T, Nakagawa H, Shimonosono M, Chandramouleeswaran P, Hara T, Sahu V, et al. Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells. Cell Mol Gastroenterol Hepatol. 2019;7:73-91 pubmed publisher
  3. Tsuruda Y, Okumura H, Setoyama T, Hiwatashi K, Minami K, Ando K, et al. Laparoscopic cholecystectomy with aberrant bile duct detected by intraoperative fluorescent cholangiography concomitant with angiography: A case report. Int J Surg Case Rep. 2018;51:14-16 pubmed publisher
    ..Our case reported for the first time that fluorescence cholangiography concomitant with angiography was useful for identifying an aberrant bile duct and the cystic artery during laparoscopic cholecystectomy. ..
  4. Kita Y, Mori S, Baba K, Uchikado Y, Arigami T, Idesako T, et al. Mucinous adenocarcinoma emerging in sigmoid colon neovagina 40 years after its creation: a case report. World J Surg Oncol. 2015;13:213 pubmed publisher
    ..Her original surgery, using sigmoid colon to construct the artificial vagina, was 40 years ago This patient's case may contribute to our understanding of carcinogenesis in the colon. ..
  5. Tamotsu K, Okumura H, Uchikado Y, Kita Y, Sasaki K, Omoto I, et al. Correlation of Aurora-A expression with the effect of chemoradiation therapy on esophageal squamous cell carcinoma. BMC Cancer. 2015;15:323 pubmed publisher
    ..Assessment of Aurora-A expression in biopsy specimens maybe useful for regarding the potential utility of CRT therapy for patients with ESCC before treatment. ..
  6. Maeda K, Ding Q, Yoshimitsu M, Kuwahata T, Miyazaki Y, Tsukasa K, et al. CD133 Modulate HIF-1? Expression under Hypoxia in EMT Phenotype Pancreatic Cancer Stem-Like Cells. Int J Mol Sci. 2016;17: pubmed publisher
    ..Understanding the function of CD133 in cancer aggressiveness provides a novel therapeutic approach to eradicate pancreatic cancer stem cells. ..
  7. Kawasaki Y, Ishigami S, Arigami T, Uenosono Y, Yanagita S, Uchikado Y, et al. Clinicopathological significance of nuclear factor (erythroid-2)-related factor 2 (Nrf2) expression in gastric cancer. BMC Cancer. 2015;15:5 pubmed publisher
    ..024). Nrf2 expression was positively associated with aggressive tumor behavior in gastric cancer. This result suggests that Nrf2 expression in gastric cancer is a potential indicator of worse prognosis. ..
  8. Matsushita D, Kurahara H, Mataki Y, Maemura K, Higashi M, Iino S, et al. Pancreatic hamartoma: a case report and literature review. BMC Gastroenterol. 2016;16:3 pubmed publisher
    ..Beside on the above findings, we suggest that the term "well-demarcated solid and cystic lesion with chronological morphological changes" could be a clinical keyword to describe pancreatic hamartomas. ..
  9. Yanagita S, Uenosono Y, Arigami T, Kita Y, Mori S, Natsugoe S. Utility of the sentinel node concept for detection of lateral pelvic lymph node metastasis in lower rectal cancer. BMC Cancer. 2017;17:433 pubmed publisher
    ..The SN concept may be useful for detecting lateral pelvic lymphatic flow and LPSN metastases, including micrometastasis in lower rectal cancer. ..

More Information


  1. Hashiguchi M, Ueno S, Sakoda M, Iino S, Hiwatashi K, Minami K, et al. Clinical implication of ZEB-1 and E-cadherin expression in hepatocellular carcinoma (HCC). BMC Cancer. 2013;13:572 pubmed publisher
    ..24). Positive ZEB-1 expression and loss of E-cadherin expression are correlated with poor prognosis in HCC patients and malignancy of ZEB-1 positive tumors involves EMT. ..
  2. Ishigami S, Ueno S, Nishizono Y, Matsumoto M, Kurahara H, Arigami T, et al. Prognostic impact of CD168 expression in gastric cancer. BMC Cancer. 2011;11:106 pubmed publisher
    ..These results suggest that cancerous CD168 expression can be used as a prognostic marker of gastric cancer owing to its interactions with stromal hyaluronic acid. ..
  3. Natsugoe S, Arigami T, Uenosono Y, Yanagita S, Nakajo A, Matsumoto M, et al. Lymph node micrometastasis in gastrointestinal tract cancer--a clinical aspect. Int J Clin Oncol. 2013;18:752-61 pubmed publisher
    ..Accurate diagnosis of LNM would clarify issues of curability and safety when performing such treatments. In the near future, individualized lymphadenectomy will develop based on the establishment of rapid, accurate diagnosis of LNM...