Setsuro Komiya

Summary

Affiliation: Kagoshima University
Country: Japan

Publications

  1. pmc Smoothened as a new therapeutic target for human osteosarcoma
    Masataka Hirotsu
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Mol Cancer 9:5. 2010
  2. pmc Bilobular calcifying fibrous pseudotumor in soleus muscle: a case report
    Naohiro Shinohara
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Med Case Reports 5:487. 2011
  3. pmc Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: functional analysis of p62 and autophagy in hypoxic neuronal cells
    Fumito Tanabe
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshima Prefecture, Japan
    Autophagy 7:1462-71. 2011
  4. pmc Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation
    Shunsuke Nakamura
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    PLoS ONE 8:e69466. 2013
  5. pmc RBPJ is a novel target for rhabdomyosarcoma therapy
    Hiroko Nagao
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    PLoS ONE 7:e39268. 2012
  6. doi request reprint GLI2 is a novel therapeutic target for metastasis of osteosarcoma
    Hiroko Nagao-Kitamoto
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Int J Cancer 136:1276-84. 2015
  7. doi request reprint Combination of Hedgehog inhibitors and standard anticancer agents synergistically prevent osteosarcoma growth
    Yoshinobu Saitoh
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8520, Japan
    Int J Oncol 48:235-42. 2016
  8. pmc Enrichment of bacteria samples by centrifugation improves the diagnosis of orthopaedics-related infections via real-time PCR amplification of the bacterial methicillin-resistance gene
    Arisa Tsuru
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    BMC Res Notes 8:288. 2015
  9. doi request reprint Role of GLI2 in the growth of human osteosarcoma
    Hiroko Nagao
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan
    J Pathol 224:169-79. 2011
  10. doi request reprint Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcoma cell growth
    Naoya Kawabata
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Int J Oncol 39:899-906. 2011

Collaborators

Detail Information

Publications51

  1. pmc Smoothened as a new therapeutic target for human osteosarcoma
    Masataka Hirotsu
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Mol Cancer 9:5. 2010
    ..To explore the involvement of aberrant Hedgehog pathway in the pathogenesis of osteosarcoma, we investigated the expression and activation of Hedgehog pathway in osteosarcoma and examined the effect of SMOOTHENED (SMO) inhibition...
  2. pmc Bilobular calcifying fibrous pseudotumor in soleus muscle: a case report
    Naohiro Shinohara
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Med Case Reports 5:487. 2011
    ..abstract:..
  3. pmc Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: functional analysis of p62 and autophagy in hypoxic neuronal cells
    Fumito Tanabe
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshima Prefecture, Japan
    Autophagy 7:1462-71. 2011
    ..These findings suggest that autophagy promotes neuronal cell survival under hypoxic stress. Our findings suggest that pharmacological inducers of autophagy may be useful for treating cervical spondylotic myelopathy patients...
  4. pmc Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation
    Shunsuke Nakamura
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    PLoS ONE 8:e69466. 2013
    ..Because ATO is an FDA-approved drug for treatment of leukemia, our findings suggest that ATO is a new therapeutic option for treatment of patients with osteosarcoma. ..
  5. pmc RBPJ is a novel target for rhabdomyosarcoma therapy
    Hiroko Nagao
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    PLoS ONE 7:e39268. 2012
    ..Our findings suggest that RBPJ regulates the RMS growth, and that the inhibition of RBPJ may be an effective therapeutic approach for patients with RMS...
  6. doi request reprint GLI2 is a novel therapeutic target for metastasis of osteosarcoma
    Hiroko Nagao-Kitamoto
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Int J Cancer 136:1276-84. 2015
    ..Consequently, our findings suggested that GLI2 regulated metastasis as well as the progression of osteosarcomas. Inhibition of the GLI2 transcription may be an effective therapeutic method for preventing osteosarcoma metastasis. ..
  7. doi request reprint Combination of Hedgehog inhibitors and standard anticancer agents synergistically prevent osteosarcoma growth
    Yoshinobu Saitoh
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8520, Japan
    Int J Oncol 48:235-42. 2016
    ..Our findings indicate that combination of Hedgehog pathway inhibitors and standard FDA-approved anticancer agents with established safety for human use may be an attractive therapeutic method for treating osteosarcoma. ..
  8. pmc Enrichment of bacteria samples by centrifugation improves the diagnosis of orthopaedics-related infections via real-time PCR amplification of the bacterial methicillin-resistance gene
    Arisa Tsuru
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    BMC Res Notes 8:288. 2015
    ..The aim of this study was to prospectively compare the utility of real-time PCR for the mecA gene detection following centrifugation of human samples with suspected orthopaedic infections...
  9. doi request reprint Role of GLI2 in the growth of human osteosarcoma
    Hiroko Nagao
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan
    J Pathol 224:169-79. 2011
    ..Our findings suggest that inhibition of GLI2 may represent an effective therapeutic approach for patients with osteosarcoma...
  10. doi request reprint Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcoma cell growth
    Naoya Kawabata
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Int J Oncol 39:899-906. 2011
    ..Our findings suggest that pharmacological inhibition of the Hedgehog pathway may be a useful approach for treating rhabdomyosarcoma patients...
  11. pmc Suppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1
    Yukihiro Matsunoshita
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    PLoS ONE 6:e16234. 2011
    ..It has been reported that EGR1 act as either tumour promoting factor or suppressor. We therefore examined the expression and function of EGR1 in osteosarcoma...
  12. pmc Cut-off values of latent infection in patients with rapid migration following bipolar hip hemiarthroplasty
    Takao Setoguchi
    The Near Future Locomotor Organ Medicine Creation Course Kusunoki Kai, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    BMC Musculoskelet Disord 17:37. 2016
    ..Although most patients achieve favorable results following bipolar hip hemiarthroplasty (BHA), some experience rapid migration of the prosthesis. We retrospectively reviewed 18 patients with BHA that necessitated revision...
  13. pmc Metastasis of osteosarcoma to the trapezius muscle: a case report
    Yuichiro Sakamoto
    Department of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    World J Surg Oncol 12:176. 2014
    ..Although the patient died of respiratory failure due to pulmonary metastasis 14 months after resection of the metastatic lesion in the trapezius muscle, no new extrapulmonary metastasis was observed after the resection. ..
  14. pmc Giant cell tumor of the clavicle: report of a case in a rare location with consideration of surgical method
    Satoshi Nagano
    Department of Orthopaedic Surgery Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    BMC Musculoskelet Disord 16:142. 2015
    ..Most bone tumors that occur in the clavicle are malignant. A few giant cell tumors (GCTs) of the clavicle have been reported; however, the most appropriate operative method for this tumor has never been discussed...
  15. pmc Risk factors for venous thromboembolism after spine surgery
    Hiroyuki Tominaga
    From the Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan HT, FT IK, sn, MA, TY, SK The Near Future Locomotor Organ Medicine Creation Course Kusunoki Kai, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan HT, TS Department of Orthopaedic Surgery, Izumi Regional Medical Center, 4513 Akasegawa, Akune 899 1611, Japan YT, NK Division of Medical and Environmental Safety, Kagoshima University Medical and Dental Hospital, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan KY and Physical Therapy Department, School of Health Sciences, Faculty of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan KY
    Medicine (Baltimore) 94:e466. 2015
    ..The most important risk factor for developing postoperative VTE was preoperative walking disability. Gait training during the early postoperative period is required to prevent VTE...
  16. doi request reprint Giant Cell Tumor of the Distal Phalanx of the Fourth Toe: A Case Report
    Masahiro Yokouchi
    Associate Professor, Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan Electronic address
    J Foot Ankle Surg 55:306-9. 2016
    ..Although bisphosphonate therapy was administered, the tumor showed highly aggressive behavior with ulceration of the overlying skin, and the patient underwent phalangeal amputation 1.5 months after diagnosis. ..
  17. doi request reprint Role of GOLPH3 and GOLPH3L in the proliferation of human rhabdomyosarcoma
    Osamu Kunigou
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8520, Japan
    Oncol Rep 26:1337-42. 2011
    ..Our findings improve the understanding of rhabdomyosarcoma pathogenesis and suggest that the knockdown of GOLPH3 or GOLPH3L may be an effective treatment for rhabdomyosarcoma...
  18. pmc SnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways
    Ichiro Kawamura
    Department of Medical Joint Materials, Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima University, Kagoshima 890 8544, Japan
    J Biol Chem 287:29101-13. 2012
    ..Our results indicate that SnoN mediates a negative feedback mechanism evoked by TGF-β to inhibit BMP signaling and, subsequently, hypertrophic maturation of chondrocytes...
  19. doi request reprint Combined posterior and delayed staged mini-open anterior short-segment fusion for thoracolumbar burst fractures
    Katsuhiro Tofuku
    Department of Orthopaedic Surgery, Imakiire General Hospital, 4 16 Shimotatsuo, Kagoshima, Japan
    J Spinal Disord Tech 25:38-46. 2012
    ..A prospective study...
  20. pmc Castleman's disease in the retroperitoneal space mimicking a paraspinal schwannoma: a case report
    Satoshi Nagano
    Department of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima City, Kagoshima, 890 8520, Japan
    World J Surg Oncol 11:108. 2013
    ..Its occurrence in the retroperitoneal space has rarely been reported, making its preoperative diagnosis difficult. Here, we report a case of retroperitoneal Castleman's disease, which radiologically resembled paraspinal schwannoma...
  21. doi request reprint Classification of odontoid destruction in patients with rheumatoid arthritis using reconstructed computed tomography: reference to vertical migration
    Hirofumi Shimada
    Orthopaedic Surgery, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    J Rheumatol 38:863-7. 2011
    ....
  22. pmc Osteoid osteoma near the intervertebral foramen may induce radiculopathy through tumorous inflammation
    Michihisa Zenmyo
    Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Diagn Pathol 6:10. 2011
    ..We present here two rare cases of spinal osteoid osteoma causing radiculopathy and the first histological evidence of tumorous inflammation as a cause of radiculopathy in osteoid osteoma near the intervertebral foramen...
  23. doi request reprint Pedicle subtraction osteotomy for adult tethered cord syndrome with lumbar canal stenosis: report of two cases
    Ichiro Kawamura
    Department of Orthopaedic Surgery, Kagoshima University, Kagoshima, Japan
    Int J Neurosci 120:735-7. 2010
    ..PSO is an alternative surgical technique for senior patients with tethered cord syndrome caused by lumbosacral spinal lipoma, when the syndrome occurs along with lumbar canal stenosis...
  24. doi request reprint Differentiation of lipoma and atypical lipomatous tumor by a scoring system: implication of increased vascularity on pathogenesis of liposarcoma
    Satoshi Nagano
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima City, Kagoshima, 890 8520, Japan
    BMC Musculoskelet Disord 16:491. 2015
    ..We evaluated the factors that may differentiate ALTs from lipomas, and validated a tentative scoring system for the diagnosis of the 2 tumor types...
  25. pmc Differentiation of lipoma and atypical lipomatous tumor by a scoring system: implication of increased vascularity on pathogenesis of liposarcoma
    Satoshi Nagano
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima City, Kagoshima, 890 8520, Japan
    BMC Musculoskelet Disord 16:36. 2015
    ..We evaluated the factors that may differentiate ALTs from lipomas, and validated a tentative scoring system for the diagnosis of the 2 tumor types...
  26. doi request reprint Ribosomal protein S3 regulates GLI2-mediated osteosarcoma invasion
    Hiroko Nagao-Kitamoto
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Cancer Lett 356:855-61. 2015
    ..These findings indicate that GLI2-RPS3 signaling may be a marker of invasive osteosarcoma and a therapeutic target for patients with osteosarcoma...
  27. doi request reprint Distractive flexion injuries of the subaxial cervical spine treated with a posterior procedure using cervical pedicle screws or a combined anterior and posterior procedure
    Katsuhiro Tofuku
    Department of Orthopaedic Surgery, Imakiire General Hospital, 4 16 Shimotatsuo, Kagoshima 892 8502, Japan
    J Clin Neurosci 20:697-701. 2013
    ..We suggest that posterior procedures with CPS fixation are reasonable for the management of cervical DF injuries...
  28. ncbi request reprint Paget disease of bone in Japanese patients: a report of three cases
    Satoshi Nagano
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Orthop Surg (Hong Kong) 21:375-9. 2013
    ..One patient with polyostotic disease did not show any change in ALP levels. The diagnosis of the disease and the indications for bisphosphonate treatment are discussed...
  29. pmc Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B: a case report
    Motoyuki Tanaka
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Diagn Pathol 7:108. 2012
    ..Orthopedic surgeons should be aware of osteomalacia and pathological hip fracture caused by drug-induced renal dysfunction, which results in Fanconi's syndrome...
  30. pmc Clinical implications of determination of safe surgical margins by using a combination of CT and 18FDG-positron emission tomography in soft tissue sarcoma
    Masahiro Yokouchi
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    BMC Musculoskelet Disord 12:166. 2011
    ....
  31. doi request reprint Intramedullary subependymoma of the cervical spinal cord: a case report with immunohistochemical study
    Michihisa Zenmyo
    Department of Orthopaedic Surgery, Kagoshima University, Japan
    Int J Neurosci 120:676-9. 2010
    ..Immunohistochemistry was useful for pathological diagnosis. The clinical feature of this patient is described with the review of literatures...
  32. doi request reprint Facet arthrography in an unusual presentation of a lumbar hemorrhagic synovial cyst
    Katsuhiro Tofuku
    Department of Orthopedic Surgery, Kagoshima Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Neurointerv Surg 4:e40. 2012
    ..A connection between the intraspinal and extraspinal lesions at the right-sided interlaminar space at the L4-L5 level was clearly noted during intraoperative examination. Histological examination revealed a hemorrhagic synovial cyst...
  33. ncbi request reprint Combination of ultrasound and bubble liposome enhance the effect of doxorubicin and inhibit murine osteosarcoma growth
    Yoshinori Ueno
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan
    Cancer Biol Ther 12:270-7. 2011
    ..US and liposomes are both very safe in the body. The DDS composed of these elements we designed can be applied in simple and site-specific fashion and is therefore promising as a new, clinically feasible method of treatment...
  34. pmc Gadd45β expression in chondrosarcoma: a pilot study for diagnostic and biological implications in histological grading
    Michihisa Zenmyo
    Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Diagn Pathol 5:69. 2010
    ....
  35. pmc Solitary breast metastasis from myxoid liposarcoma
    Masahiro Yokouchi
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    BMC Cancer 14:482. 2014
    ..To the best of our knowledge, no isolated case reports of solitary breast metastasis by myxoid liposarcoma have been previously reported in the English-language literature...
  36. pmc Risk of low bone mineral density in patients with rheumatoid arthritis treated with biologics
    Kengo Takahashi
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    BMC Musculoskelet Disord 16:269. 2015
    ..Osteoporosis is a complication of rheumatoid arthritis (RA). We identified risk factors for osteoporosis during treatment with biologics...
  37. doi request reprint A bundle that includes active surveillance, contact precaution for carriers, and cefazolin-based antimicrobial prophylaxis prevents methicillin-resistant Staphylococcus aureus infections in clean orthopedic surgery
    Hideki Kawamura
    Division of Medical and Environmental Safety, Department of Infection Control and Prevention, Kagoshima University Hospital, Kagoshima, Japan Department of Orthopaedic Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan Electronic address
    Am J Infect Control 44:210-4. 2016
    ..Methicillin-resistant Staphylococcus aureus (MRSA) is a frequent cause of orthopedic surgical site infections (SSIs). The aim of this study was to evaluate the effect of a bundle approach in the prevention of orthopedic MRSA SSIs...
  38. ncbi request reprint Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of osteosarcoma
    Yasuomi Kawasoe
    Department of Orthopaedic Surgery, Kagoshima Graduate School of Medical and Dental Sciences, Kagoshima 890 8520, Japan
    Oncol Rep 22:1045-50. 2009
    ..These findings suggest that hyperbaric oxygen plus carboplatin combination therapy could be an appropriate therapeutic regimen for the treatment of patients with osteosarcoma...
  39. pmc Dropped head syndrome due to myogenic atrophy - a case report of surgical treatment
    Michihisa Zenmyo
    Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Diagn Pathol 6:9. 2011
    ..Pathologic study confirmed myogenic atrophy in the cervical extensor muscles. We suggest that consideration for surgical management should be given to dropped head syndrome especially due to INEM...
  40. pmc The use of antibiotic-impregnated fibrin sealant for the prevention of surgical site infection associated with spinal instrumentation
    Katsuhiro Tofuku
    Department of Orthopaedic Surgery, Imakiire General Hospital, 4 16 Shimotatsuo, Kagoshima, Japan
    Eur Spine J 21:2027-33. 2012
    ..The purpose of this study was to determine if the use of antibiotic-impregnated fibrin sealant (AFS) was effective in preventing surgical site infections (SSI) associated with spinal instrumentation...
  41. doi request reprint Intradural neurenteric cyst--two case reports of surgical treatment
    Michihisa Zenmyo
    Department of Orthopaedic Surgery, Kagoshima University, Kagoshima, Japan
    Int J Neurosci 120:625-9. 2010
    ..In conclusion, two cases of intradural extramedullary cysts are reported. Clinical presentations, intraoperative findings, and histological features are discussed with a review of the literature...
  42. ncbi request reprint N-myc downstream-regulated gene 1/Cap43 expression promotes cell differentiation of human osteosarcoma cells
    Toru Matsugaki
    Department of Orthopaedic Surgery, Kurume University School of Medicine, Kurume 830 0011, Japan
    Oncol Rep 24:721-5. 2010
    ..On the basis of these results, our proposed role for NDRG1/Cap43 would be in the capacity of differentiation and invasion in osteosarcoma cells...
  43. doi request reprint Facet arthrography of a cervical synovial cyst
    Katsuhiro Tofuku
    Department of Orthopedic Surgery, Kagoshima Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Neurointerv Surg 4:e17. 2012
    ..In this case, facet arthrography allowed the preoperative determination of communication between the extradural lesion and the facet joint, leading to the diagnosis of a synovial cyst...
  44. doi request reprint The diagnostic value of single-photon emission computed tomography/computed tomography for severe sacroiliac joint dysfunction
    Katsuhiro Tofuku
    Department of Orthopedic Surgery, Imakiire General Hospital, 4 16 Shimotatsuo, Kagoshima, 892 8502, Japan
    Eur Spine J 24:859-63. 2015
    ..We aimed to evaluate the value of single-photon emission computed tomography (SPECT)/computed tomography (CT) for the diagnosis of sacroiliac joint (SIJ) dysfunction...
  45. doi request reprint Effects of blood purification therapy on a patient with ifosfamide-induced neurotoxicity and acute kidney injury
    Hiroaki Nishimura
    Blood Purification Center, Kagoshima University Hospital, 8 35 1, Sakuragaoka, Kagoshima, Kagoshima, 890 8520, Japan
    J Artif Organs 17:110-3. 2014
    ..Despite the absence of an established detoxification method when complications present simultaneously, blood purification therapy should be considered for treating severe concurrent neurotoxicity and nephrotoxicity and rhabdomyolysis...
  46. pmc Subdural spread of injected local anesthetic in a selective transforaminal cervical nerve root block: a case report
    Katsuhiro Tofuku
    Department of Orthopedic Surgery, Imakiire General Hospital, Kagoshima, Japan
    J Med Case Rep 6:142. 2012
    ..abstract:..
  47. pmc Senescence of chondrocytes in aging articular cartilage: GADD45β mediates p21 expression in association with C/EBPβ in senescence-accelerated mice
    Hirofumi Shimada
    Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima, 890 8520, Japan
    Pathol Res Pract 207:225-31. 2011
    ..Co-expression of C/EBPβ and p21 was confirmed. These observations suggest that the synergism between GADD45β and C/EBPβ may play an important role in cellular senescence in the aging articular cartilage...
  48. doi request reprint Quantitative analysis of biofilm formation of methicillin-resistant Staphylococcus aureus (MRSA) strains from patients with orthopaedic device-related infections
    Hideki Kawamura
    Kagoshima University Hospital, Infection Control Team, Kagoshima, Japan
    FEMS Immunol Med Microbiol 63:10-5. 2011
    ..7%, P=0.003) and the colonization group (20.0%, P=0.020). agr-2 MRSA strains may be more likely to cause orthopaedic device infection because of their strong biofilm formation ability...
  49. pmc Survivin-responsive conditionally replicating adenovirus kills rhabdomyosarcoma stem cells more efficiently than their progeny
    Kiyonori Tanoue
    Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Transl Med 12:27. 2014
    ..Here we examined the therapeutic potentials of a Surv.m-CRA against rhabdomyosarcoma stem cells (RSCs), in order to assess its clinical effectiveness and usefulness...
  50. doi request reprint Ependymal cyst in the conus medullaris
    Satoshi Nagano
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Clin Neurosci 17:272-3. 2010
    ..The basement membrane was absent in the cyst wall. Reactivity to CAM5.2 and AE1/AE3 anti-keratin antibodies suggested that the cyst was of neuroepithelial origin. No recurrence has been noted 3 years after surgery...
  51. doi request reprint High mobility group box 1 is upregulated after spinal cord injury and is associated with neuronal cell apoptosis
    Hideyuki Kawabata
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    Spine (Phila Pa 1976) 35:1109-15. 2010
    ..In addition, relationship between upregulation of HMGB1 and neural cells apoptosis was evaluated after SCI...