Setsuro Komiya

Summary

Affiliation: Kagoshima University
Country: Japan

Publications

  1. pmc Smoothened as a new therapeutic target for human osteosarcoma
    Masataka Hirotsu
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Mol Cancer 9:5. 2010
  2. pmc Bilobular calcifying fibrous pseudotumor in soleus muscle: a case report
    Naohiro Shinohara
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Med Case Reports 5:487. 2011
  3. pmc Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: functional analysis of p62 and autophagy in hypoxic neuronal cells
    Fumito Tanabe
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshima Prefecture, Japan
    Autophagy 7:1462-71. 2011
  4. pmc RBPJ is a novel target for rhabdomyosarcoma therapy
    Hiroko Nagao
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    PLoS ONE 7:e39268. 2012
  5. doi request reprint Role of GLI2 in the growth of human osteosarcoma
    Hiroko Nagao
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan
    J Pathol 224:169-79. 2011
  6. doi request reprint Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcoma cell growth
    Naoya Kawabata
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Int J Oncol 39:899-906. 2011
  7. pmc Suppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1
    Yukihiro Matsunoshita
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    PLoS ONE 6:e16234. 2011
  8. doi request reprint Combined posterior and delayed staged mini-open anterior short-segment fusion for thoracolumbar burst fractures
    Katsuhiro Tofuku
    Department of Orthopaedic Surgery, Imakiire General Hospital, 4 16 Shimotatsuo, Kagoshima, Japan
    J Spinal Disord Tech 25:38-46. 2012
  9. pmc Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation
    Shunsuke Nakamura
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    PLoS ONE 8:e69466. 2013
  10. doi request reprint Role of GOLPH3 and GOLPH3L in the proliferation of human rhabdomyosarcoma
    Osamu Kunigou
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8520, Japan
    Oncol Rep 26:1337-42. 2011

Collaborators

Detail Information

Publications32

  1. pmc Smoothened as a new therapeutic target for human osteosarcoma
    Masataka Hirotsu
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Mol Cancer 9:5. 2010
    ..To explore the involvement of aberrant Hedgehog pathway in the pathogenesis of osteosarcoma, we investigated the expression and activation of Hedgehog pathway in osteosarcoma and examined the effect of SMOOTHENED (SMO) inhibition...
  2. pmc Bilobular calcifying fibrous pseudotumor in soleus muscle: a case report
    Naohiro Shinohara
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Med Case Reports 5:487. 2011
    ..abstract:..
  3. pmc Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: functional analysis of p62 and autophagy in hypoxic neuronal cells
    Fumito Tanabe
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshima Prefecture, Japan
    Autophagy 7:1462-71. 2011
    ..These findings suggest that autophagy promotes neuronal cell survival under hypoxic stress. Our findings suggest that pharmacological inducers of autophagy may be useful for treating cervical spondylotic myelopathy patients...
  4. pmc RBPJ is a novel target for rhabdomyosarcoma therapy
    Hiroko Nagao
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    PLoS ONE 7:e39268. 2012
    ..Our findings suggest that RBPJ regulates the RMS growth, and that the inhibition of RBPJ may be an effective therapeutic approach for patients with RMS...
  5. doi request reprint Role of GLI2 in the growth of human osteosarcoma
    Hiroko Nagao
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan
    J Pathol 224:169-79. 2011
    ..Our findings suggest that inhibition of GLI2 may represent an effective therapeutic approach for patients with osteosarcoma...
  6. doi request reprint Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcoma cell growth
    Naoya Kawabata
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Int J Oncol 39:899-906. 2011
    ..Our findings suggest that pharmacological inhibition of the Hedgehog pathway may be a useful approach for treating rhabdomyosarcoma patients...
  7. pmc Suppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1
    Yukihiro Matsunoshita
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    PLoS ONE 6:e16234. 2011
    ..It has been reported that EGR1 act as either tumour promoting factor or suppressor. We therefore examined the expression and function of EGR1 in osteosarcoma...
  8. doi request reprint Combined posterior and delayed staged mini-open anterior short-segment fusion for thoracolumbar burst fractures
    Katsuhiro Tofuku
    Department of Orthopaedic Surgery, Imakiire General Hospital, 4 16 Shimotatsuo, Kagoshima, Japan
    J Spinal Disord Tech 25:38-46. 2012
    ..A prospective study...
  9. pmc Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation
    Shunsuke Nakamura
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    PLoS ONE 8:e69466. 2013
    ..Because ATO is an FDA-approved drug for treatment of leukemia, our findings suggest that ATO is a new therapeutic option for treatment of patients with osteosarcoma. ..
  10. doi request reprint Role of GOLPH3 and GOLPH3L in the proliferation of human rhabdomyosarcoma
    Osamu Kunigou
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8520, Japan
    Oncol Rep 26:1337-42. 2011
    ..Our findings improve the understanding of rhabdomyosarcoma pathogenesis and suggest that the knockdown of GOLPH3 or GOLPH3L may be an effective treatment for rhabdomyosarcoma...
  11. pmc SnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways
    Ichiro Kawamura
    Department of Medical Joint Materials, Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima University, Kagoshima 890 8544, Japan
    J Biol Chem 287:29101-13. 2012
    ..Our results indicate that SnoN mediates a negative feedback mechanism evoked by TGF-β to inhibit BMP signaling and, subsequently, hypertrophic maturation of chondrocytes...
  12. pmc Osteoid osteoma near the intervertebral foramen may induce radiculopathy through tumorous inflammation
    Michihisa Zenmyo
    Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Diagn Pathol 6:10. 2011
    ..We present here two rare cases of spinal osteoid osteoma causing radiculopathy and the first histological evidence of tumorous inflammation as a cause of radiculopathy in osteoid osteoma near the intervertebral foramen...
  13. doi request reprint Classification of odontoid destruction in patients with rheumatoid arthritis using reconstructed computed tomography: reference to vertical migration
    Hirofumi Shimada
    Orthopaedic Surgery, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    J Rheumatol 38:863-7. 2011
    ....
  14. doi request reprint Pedicle subtraction osteotomy for adult tethered cord syndrome with lumbar canal stenosis: report of two cases
    Ichiro Kawamura
    Department of Orthopaedic Surgery, Kagoshima University, Kagoshima, Japan
    Int J Neurosci 120:735-7. 2010
    ..PSO is an alternative surgical technique for senior patients with tethered cord syndrome caused by lumbosacral spinal lipoma, when the syndrome occurs along with lumbar canal stenosis...
  15. doi request reprint Intramedullary subependymoma of the cervical spinal cord: a case report with immunohistochemical study
    Michihisa Zenmyo
    Department of Orthopaedic Surgery, Kagoshima University, Japan
    Int J Neurosci 120:676-9. 2010
    ..Immunohistochemistry was useful for pathological diagnosis. The clinical feature of this patient is described with the review of literatures...
  16. pmc Gadd45β expression in chondrosarcoma: a pilot study for diagnostic and biological implications in histological grading
    Michihisa Zenmyo
    Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Diagn Pathol 5:69. 2010
    ....
  17. pmc Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B: a case report
    Motoyuki Tanaka
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Diagn Pathol 7:108. 2012
    ..VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1600344696739249...
  18. ncbi request reprint Combination of ultrasound and bubble liposome enhance the effect of doxorubicin and inhibit murine osteosarcoma growth
    Yoshinori Ueno
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan
    Cancer Biol Ther 12:270-7. 2011
    ..US and liposomes are both very safe in the body. The DDS composed of these elements we designed can be applied in simple and site-specific fashion and is therefore promising as a new, clinically feasible method of treatment...
  19. pmc Clinical implications of determination of safe surgical margins by using a combination of CT and 18FDG-positron emission tomography in soft tissue sarcoma
    Masahiro Yokouchi
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    BMC Musculoskelet Disord 12:166. 2011
    ....
  20. doi request reprint Facet arthrography in an unusual presentation of a lumbar hemorrhagic synovial cyst
    Katsuhiro Tofuku
    Department of Orthopedic Surgery, Kagoshima Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Neurointerv Surg 4:e40. 2012
    ..A connection between the intraspinal and extraspinal lesions at the right-sided interlaminar space at the L4-L5 level was clearly noted during intraoperative examination. Histological examination revealed a hemorrhagic synovial cyst...
  21. pmc Castleman's disease in the retroperitoneal space mimicking a paraspinal schwannoma: a case report
    Satoshi Nagano
    Department of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima City, Kagoshima, 890 8520, Japan
    World J Surg Oncol 11:108. 2013
    ..Its occurrence in the retroperitoneal space has rarely been reported, making its preoperative diagnosis difficult. Here, we report a case of retroperitoneal Castleman's disease, which radiologically resembled paraspinal schwannoma...
  22. ncbi request reprint Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of osteosarcoma
    Yasuomi Kawasoe
    Department of Orthopaedic Surgery, Kagoshima Graduate School of Medical and Dental Sciences, Kagoshima 890 8520, Japan
    Oncol Rep 22:1045-50. 2009
    ..These findings suggest that hyperbaric oxygen plus carboplatin combination therapy could be an appropriate therapeutic regimen for the treatment of patients with osteosarcoma...
  23. pmc Dropped head syndrome due to myogenic atrophy - a case report of surgical treatment
    Michihisa Zenmyo
    Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Diagn Pathol 6:9. 2011
    ..Pathologic study confirmed myogenic atrophy in the cervical extensor muscles. We suggest that consideration for surgical management should be given to dropped head syndrome especially due to INEM...
  24. pmc The use of antibiotic-impregnated fibrin sealant for the prevention of surgical site infection associated with spinal instrumentation
    Katsuhiro Tofuku
    Department of Orthopaedic Surgery, Imakiire General Hospital, 4 16 Shimotatsuo, Kagoshima, Japan
    Eur Spine J 21:2027-33. 2012
    ..The purpose of this study was to determine if the use of antibiotic-impregnated fibrin sealant (AFS) was effective in preventing surgical site infections (SSI) associated with spinal instrumentation...
  25. ncbi request reprint N-myc downstream-regulated gene 1/Cap43 expression promotes cell differentiation of human osteosarcoma cells
    Toru Matsugaki
    Department of Orthopaedic Surgery, Kurume University School of Medicine, Kurume 830 0011, Japan
    Oncol Rep 24:721-5. 2010
    ..On the basis of these results, our proposed role for NDRG1/Cap43 would be in the capacity of differentiation and invasion in osteosarcoma cells...
  26. doi request reprint Intradural neurenteric cyst--two case reports of surgical treatment
    Michihisa Zenmyo
    Department of Orthopaedic Surgery, Kagoshima University, Kagoshima, Japan
    Int J Neurosci 120:625-9. 2010
    ..In conclusion, two cases of intradural extramedullary cysts are reported. Clinical presentations, intraoperative findings, and histological features are discussed with a review of the literature...
  27. doi request reprint Facet arthrography of a cervical synovial cyst
    Katsuhiro Tofuku
    Department of Orthopedic Surgery, Kagoshima Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Neurointerv Surg 4:e17. 2012
    ..In this case, facet arthrography allowed the preoperative determination of communication between the extradural lesion and the facet joint, leading to the diagnosis of a synovial cyst...
  28. pmc Subdural spread of injected local anesthetic in a selective transforaminal cervical nerve root block: a case report
    Katsuhiro Tofuku
    Department of Orthopedic Surgery, Imakiire General Hospital, Kagoshima, Japan
    J Med Case Rep 6:142. 2012
    ..abstract:..
  29. pmc Senescence of chondrocytes in aging articular cartilage: GADD45β mediates p21 expression in association with C/EBPβ in senescence-accelerated mice
    Hirofumi Shimada
    Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima, 890 8520, Japan
    Pathol Res Pract 207:225-31. 2011
    ..Co-expression of C/EBPβ and p21 was confirmed. These observations suggest that the synergism between GADD45β and C/EBPβ may play an important role in cellular senescence in the aging articular cartilage...
  30. doi request reprint Quantitative analysis of biofilm formation of methicillin-resistant Staphylococcus aureus (MRSA) strains from patients with orthopaedic device-related infections
    Hideki Kawamura
    Kagoshima University Hospital, Infection Control Team, Kagoshima, Japan
    FEMS Immunol Med Microbiol 63:10-5. 2011
    ..7%, P=0.003) and the colonization group (20.0%, P=0.020). agr-2 MRSA strains may be more likely to cause orthopaedic device infection because of their strong biofilm formation ability...
  31. doi request reprint High mobility group box 1 is upregulated after spinal cord injury and is associated with neuronal cell apoptosis
    Hideyuki Kawabata
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    Spine (Phila Pa 1976) 35:1109-15. 2010
    ..In addition, relationship between upregulation of HMGB1 and neural cells apoptosis was evaluated after SCI...
  32. doi request reprint Ependymal cyst in the conus medullaris
    Satoshi Nagano
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Clin Neurosci 17:272-3. 2010
    ..The basement membrane was absent in the cyst wall. Reactivity to CAM5.2 and AE1/AE3 anti-keratin antibodies suggested that the cyst was of neuroepithelial origin. No recurrence has been noted 3 years after surgery...