Sumiya Ishigami

Summary

Affiliation: Kagoshima University
Country: Japan

Publications

  1. ncbi IL-32 expression is an independent prognostic marker for gastric cancer
    Sumiya Ishigami
    Digestive Surgery Surgical Oncology, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Med Oncol 30:472. 2013
  2. ncbi Cancerous HLA class I expression and regulatory T cell infiltration in gastric cancer
    Sumiya Ishigami
    Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Cancer Immunol Immunother 61:1663-9. 2012
  3. ncbi Biological aggressiveness of alpha-fetoprotein (AFP)-positive gastric cancer
    Sumiya Ishigami
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890, Japan
    Hepatogastroenterology 53:338-41. 2006
  4. ncbi HLA-class I expression in gastric cancer
    Sumiya Ishigami
    Digestive Surgery Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan
    J Surg Oncol 97:605-8. 2008
  5. ncbi Tumor-associated macrophage (TAM) infiltration in gastric cancer
    Sumiya Ishigami
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890, Japan
    Anticancer Res 23:4079-83. 2003
  6. ncbi Usefulness of sentinel node biopsy in laparoscopic partial gastrectomy for early gastric cancer
    Sumiya Ishigami
    Surgical Oncology, Digestive Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890, Japan
    Hepatogastroenterology 54:2164-6. 2007
  7. ncbi Preoperative assessment of the depth of early gastric cancer invasion by transabdominal ultrasound sonography (TUS): a comparison with endoscopic ultrasound sonography (EUS)
    Sumiya Ishigami
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890, Japan
    Hepatogastroenterology 51:1202-5. 2004
  8. ncbi CD3 zeta expression of regional lymph node and peripheral blood lymphocytes in gastric cancer
    Sumiya Ishigami
    First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
    Anticancer Res 24:2123-6. 2004
  9. ncbi Clinical implication of CXCL12 expression in gastric cancer
    Sumiya Ishigami
    Digestive Surgery Surgical Oncology, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    Ann Surg Oncol 14:3154-8. 2007
  10. ncbi Prognostic value of CCR7 expression in gastric cancer
    Sumiya Ishigami
    Department of Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan
    Hepatogastroenterology 54:1025-8. 2007

Collaborators

Detail Information

Publications96

  1. ncbi IL-32 expression is an independent prognostic marker for gastric cancer
    Sumiya Ishigami
    Digestive Surgery Surgical Oncology, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Med Oncol 30:472. 2013
    ..Pro-inflammatory cytokines induce immunosuppression in a paracrine manner, thereby facilitating the metastasis of tumor cells...
  2. ncbi Cancerous HLA class I expression and regulatory T cell infiltration in gastric cancer
    Sumiya Ishigami
    Department of Digestive Surgery, and Breast and Thyroid Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Cancer Immunol Immunother 61:1663-9. 2012
    ..In the current study, we investigated HLA class I expression and Treg cells infiltration in gastric cancer and discussed the clinical implications of this combinatory analysis in gastric cancer...
  3. ncbi Biological aggressiveness of alpha-fetoprotein (AFP)-positive gastric cancer
    Sumiya Ishigami
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890, Japan
    Hepatogastroenterology 53:338-41. 2006
    ..However, little information regarding the clinicopathological and biological behaviors of APGC is available due to the small size of reported series...
  4. ncbi HLA-class I expression in gastric cancer
    Sumiya Ishigami
    Digestive Surgery Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan
    J Surg Oncol 97:605-8. 2008
    ..We investigated the clinical impact of HLA-class I tumor cells in gastric cancer...
  5. ncbi Tumor-associated macrophage (TAM) infiltration in gastric cancer
    Sumiya Ishigami
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890, Japan
    Anticancer Res 23:4079-83. 2003
    ..Tumor-associated macrophages (TAMs) are defined as macrophages that migrate into the tumor stroma. TAMs are known to directly or indirectly affect immune suppression. TAMs have not previously been reported in gastric cancer...
  6. ncbi Usefulness of sentinel node biopsy in laparoscopic partial gastrectomy for early gastric cancer
    Sumiya Ishigami
    Surgical Oncology, Digestive Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890, Japan
    Hepatogastroenterology 54:2164-6. 2007
    ..Five patients having early gastric cancer were treated using laparoscopic partial gastrectomy combined with sentinel lymph node biopsy...
  7. ncbi Preoperative assessment of the depth of early gastric cancer invasion by transabdominal ultrasound sonography (TUS): a comparison with endoscopic ultrasound sonography (EUS)
    Sumiya Ishigami
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890, Japan
    Hepatogastroenterology 51:1202-5. 2004
    ..We retrospectively analyzed the clinical efficacy of preoperative evaluation by TUS in early gastric cancer in comparison with endoscopic ultrasound sonography (EUS)...
  8. ncbi CD3 zeta expression of regional lymph node and peripheral blood lymphocytes in gastric cancer
    Sumiya Ishigami
    First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
    Anticancer Res 24:2123-6. 2004
    ....
  9. ncbi Clinical implication of CXCL12 expression in gastric cancer
    Sumiya Ishigami
    Digestive Surgery Surgical Oncology, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    Ann Surg Oncol 14:3154-8. 2007
    ..This study immunohistochemically investigated CXCL12 expression in gastric cancer and evaluated its association with clinical factors, including patient prognosis...
  10. ncbi Prognostic value of CCR7 expression in gastric cancer
    Sumiya Ishigami
    Department of Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan
    Hepatogastroenterology 54:1025-8. 2007
    ..However, there is little information regarding the clinical implications of CCR7-positive gastric cancer...
  11. ncbi Small bowel obstruction secondary to Meckel diverticulum detected and treated laparoscopically--case report
    Sumiya Ishigami
    Surgical Department of Saiseikai Sendai Hospital, Kagoshima, Japan
    Surg Laparosc Endosc Percutan Tech 16:344-6. 2006
    ..The patient was discharged without postoperative complications. Laparoscopic procedures are useful in identifying rare causes of bowel obstruction and to determine an appropriate access point for treatment...
  12. ncbi HLA-G expression in gastric cancer
    Sumiya Ishigami
    Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan
    Anticancer Res 26:2467-72. 2006
    ..Ectopic HLA-G expression in tumor cells may indicate immune escape from the host immune defense via the inhibitory receptor on natural killer (NK) cells. However, there is little information on HLA-G expression in gastric cancer...
  13. ncbi Salvage gastrectomy following a combination of biweekly paclitaxel and S-1 for stage IV gastric cancer
    Sumiya Ishigami
    Digestive Surgery, Surgical Oncology, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima, 890, Japan
    J Gastrointest Surg 12:1370-5. 2008
    ..We investigated the clinical benefits of salvage gastrectomy for stage IV gastric cancer patients whose distant lesions showed complete response after chemotherapy...
  14. ncbi Clinical implication of CD166 expression in gastric cancer
    Sumiya Ishigami
    Digestive Surgery, Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan
    J Surg Oncol 103:57-61. 2011
    ..Its expression is associated with aggressive tumor behavior. CD166 expression is a prognostic marker in several cancers, but the predictive value of CD166 expression in gastric cancer has not been clarified yet...
  15. ncbi Prognostic impact of CD133 expression in gastric carcinoma
    Sumiya Ishigami
    Digestive Surgery, Surgical Oncology, Kagoshima University School of Medicine 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Anticancer Res 30:2453-7. 2010
    ..CD133 expression was evaluated in gastric cancer and the clinical impact of CD133-positive gastric cancer was clarified...
  16. ncbi Roux-en-Y reconstruction with stapled distal jejunal pouch after total gastrectomy
    Sumiya Ishigami
    Digestive Surgery and Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan
    Am Surg 76:526-8. 2010
    ..This procedure may improve postoperative malnutrition after total gastrectomy according to our feasible study. A multicenter randomized trial of this approach comparing with Roux-en-Y reconstruction without a pouch is ongoing...
  17. ncbi Prognostic value of CD208-positive cell infiltration in gastric cancer
    Sumiya Ishigami
    Kagoshima University School of Medicine, Sakuragaoka, Japan
    Cancer Immunol Immunother 59:389-95. 2010
    ..In this study, we tried to clarify the clinical implication of CD208-positive cell infiltration in gastric cancer immunohistochemically...
  18. ncbi Prognostic impact of CD168 expression in gastric cancer
    Sumiya Ishigami
    Digestive Surgery Surgical Oncology, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka Kagoshima 890 8520, Japan
    BMC Cancer 11:106. 2011
    ..Cancerous CD168 expression is correlated with aggressive biological features in several cancers. However, the clinical implications of CD168 positivity in gastric cancer have remained unclear...
  19. ncbi Infiltration of antitumor immunocytes into the sentinel node in gastric cancer
    Sumiya Ishigami
    First Department of Surgery, Kagoshima University School of Medicine, Sakuragaoka, Kagoshima, Japan
    J Gastrointest Surg 7:735-9. 2003
    ..Studies in progress will help to identify immunologic paralysis of the SN in various types of cancer. Attention must therefore be paid to organ specificity...
  20. ncbi Postoperative long-term evaluation of interposition reconstruction compared with Roux-en-Y after total gastrectomy in gastric cancer: prospective randomized controlled trial
    Sumiya Ishigami
    Office of the Japanese Society for Gastro surgical Pathophysiology Groups, Department of Digestive Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Am J Surg 202:247-53. 2011
    ..Postoperative quality of life (QOL) was evaluated between the 2 methods by a multi-institutional prospective randomized trial...
  21. ncbi Pancreatic mucinous cyst adenocarcinoma producing CA 19-9. A case report
    Sumiya Ishigami
    Gastrointestinal Surgery, Surgical Oncology, Kagoshima University School of Medicine, Japan
    JOP 8:228-31. 2007
    ..We herein present a rare case of a mucinous cystic neoplasm of the pancreas producing CA 19-9 and the clinical implications are discussed...
  22. ncbi Vascular endothelial growth factor-C and -D expression correlates with lymph node micrometastasis in pN0 early gastric cancer
    Takaaki Arigami
    Department of Surgical Oncology and Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Surg Oncol 99:148-53. 2009
    ..The present study investigates the expression of VEGF-C and -D in early gastric cancer and analyzes its relationship to lymph node micrometastasis determined by reverse transcription-polymerase chain reaction (RT-PCR)...
  23. ncbi [Clinical efficacy of biweekly paclitaxel and S-1 regimen for 14 gastric cancer patients with liver metastases]
    Sumiya Ishigami
    Surgical Oncology, Digestive Surgery, Kagoshima University School of Medicine
    Gan To Kagaku Ryoho 34:569-72. 2007
    ..Histological exploration revealed disappearance of liver metastases. In conclusion, biweekly paclitaxel+S-1 regimen was one of the promising therapies for advanced gastric cancer patients with liver metastases...
  24. ncbi Improvement in radiosensitivity using small interfering RNA targeting p53R2 in esophageal squamous cell carcinoma
    Naoya Yokomakura
    Department of Surgical Oncology and Digestive Surgery, Graduate School of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    Oncol Rep 18:561-7. 2007
    ..This protocol could potentially improve the efficacy of radiation therapy...
  25. ncbi Carcinoembryonic antigen messenger RNA expression in blood can predict relapse in gastric cancer
    Sumiya Ishigami
    Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
    J Surg Res 148:205-9. 2008
    ..To clarify the clinical implications of intraoperative carcinoembryonic antigen (CEA) mRNA copy number in peripheral blood samples from gastric cancer patients...
  26. ncbi The successfully curative treatment of advanced gastric adenocarcinoma with multiple liver metastases and paraaortic lymph node metastases by salvage operation following the biweekly paclitaxel and S-1 combination chemotherapy: a case report
    Ken Sasaki
    Department of Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
    Hepatogastroenterology 54:2421-4. 2007
    ..Biweekly paclitaxel and S-1 combination chemotherapy has been used safely and its administration may be continued for a long time in an outpatient clinic setting for the treatment of advanced gastric cancer...
  27. ncbi CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer
    Takaaki Arigami
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890 8520, Japan
    Int J Oncol 35:19-24. 2009
    ..0021). Assessment of CCR7 and CXCR4 expression in gastric cancer is a useful tool for predicting lymph node metastatic status including LNMM...
  28. ncbi Predictive value of p53 and 14-3-3sigma for the effect of chemoradiation therapy on esophageal squamous cell carcinoma
    Hiroshi Okumura
    Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, Kagoshima, Japan
    J Surg Oncol 91:84-9. 2005
    ....
  29. ncbi CD3-zetachain expression of intratumoral lymphocytes is closely related to survival in gastric carcinoma patients
    Sumiya Ishigami
    First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
    Cancer 94:1437-42. 2002
    ..The clinical significance of CD3-zeta chain expression in tumor-infiltrating lymphocytes (TILs) in gastric carcinoma remains unclear...
  30. ncbi Increased Slug and decreased E-cadherin expression is related to poor prognosis in patients with gastric cancer
    Yasuto Uchikado
    Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, Kagoshima, 890 8520, Japan
    Gastric Cancer 14:41-9. 2011
    ..The purpose of the present study was to evaluate the clinical significance of E-cadherin and Slug expression in gastric cancer...
  31. ncbi Immediate breast reconstruction using autologous free dermal fat grafts provides better cosmetic results for patients with upper inner cancerous lesions
    Yuko Kijima
    Department of Surgical Oncology, Breast and Endocrine Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    Surg Today 41:477-89. 2011
    ..This study analyzes our use of autologous free dermal fat grafts (FDFGs) for immediate breast reconstruction...
  32. ncbi Successful treatment of advanced gastric cancer by surgical resection following combination chemotherapy with oral S-1 and biweekly paclitaxel
    Akihiro Nakajo
    Department of Digestive Surgery and Surgical Oncology, Kagoshima University Graduate School of Medical and Dental Science, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    Gastric Cancer 10:58-62. 2007
    ..The tumor was pathologically diagnosed as pT2, pN0, P0, M0, CY0, and p-stage II. The patient is healthy over 4 years after surgery without recurrence...
  33. ncbi Distribution of lymph node metastasis including micrometastasis in gastric cancer with submucosal invasion
    Hiroshi Higashi
    First Department of Surgery, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
    World J Surg 27:455-9. 2003
    ..When planning minimally invasive treatment for submucosal gastric cancer, it is important to understand the distribution of lymph node metastasis, including micrometastasis, according to tumor location...
  34. ncbi Clinicopathological significance of BMP7 expression in esophageal squamous cell carcinoma
    Koichi Megumi
    Department of Surgical Oncology, Digestive Surgery, Kagoshima University, Graduate School of Medicine, Kagoshima, Japan
    Ann Surg Oncol 19:2066-71. 2012
    ..The purpose of the current study was to examine the expression of BMP7 in esophageal squamous cell carcinoma and to clarify the clinical impact of BMP7 expression in esophageal squamous cell carcinoma (ESCC)...
  35. ncbi Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma
    Hiroyuki Takatori
    Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Oncol Rep 13:697-701. 2005
    ..COX-2 mRNA expression in biopsy specimens was closely related to CRT effectiveness. Examination of COX-2 mRNA expression is useful for predicting the effect of CRT in patients with ESCC...
  36. ncbi Sentinel node micrometastases have high proliferative potential in gastric cancer
    Shigehiro Yanagita
    Course of Advanced Therapeutics, Field of Oncology, Department of Surgical Oncology and Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Surg Res 145:238-43. 2008
    ..quot; The present study examines the frequency and proliferative activity of such metastases with focus on the SNs of gastric cancer...
  37. ncbi Carcinoembryonic antigen messenger RNA expression in blood predicts recurrence in esophageal cancer
    Tetsuro Setoyama
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University, Graduate School of Medical and Dental Science, Kagoshima, Japan
    Clin Cancer Res 12:5972-7. 2006
    ..We conducted a longitudinal analysis of the relationship between ITC in blood during follow-up and clinicopathologic findings in patients with esophageal squamous cell carcinoma...
  38. ncbi Overexpression of vascular endothelial growth factor-C correlates with lymph node micrometastasis in submucosal esophageal cancer
    Masataka Matsumoto
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Gastrointest Surg 10:1016-22. 2006
    ..0001 and P < 0.01, respectively). The present findings indicate that in ESCC with submucosal invasion, VEGF-C overexpression of the primary tumor is a strong high risk factor for lymph node metastasis, including LMM...
  39. ncbi Expression of CXCL12 and its receptor CXCR4 in esophageal squamous cell carcinoma
    Ken Sasaki
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890 8520, Japan
    Oncol Rep 21:65-71. 2009
    ..Evaluation of CXCL12 expression is useful for determining tumor properties, including nodal metastasis and prognosis in patients with ESCC...
  40. ncbi Clinical implication of HLA class I expression in breast cancer
    Koichi Kaneko
    Department of Surgical Oncology, Breast and Endocrine Surgery, Kagoshima University School of Medicine, Japan
    BMC Cancer 11:454. 2011
    ..However, the clinical impact of HLA class I expression in breast cancer has not been clarified...
  41. ncbi Expression of stanniocalcin 1 as a potential biomarker of gastric cancer
    Takaaki Arigami
    Department of Digestive Surgery, Breast and Thyroid Surgery, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Oncology 83:158-64. 2012
    ..We investigated stanniocalcin 1 (STC 1) expression to assess its clinical utility as a blood marker in patients with gastric cancer and evaluated its biological impact in terms of tumor aggressiveness...
  42. ncbi Endoscopic ultrasonography is useful for monitoring the tumor response of neoadjuvant chemoradiation therapy in esophageal squamous cell carcinoma
    Tetsuhiro Owaki
    Education Center for Doctors in Remote Islands and Rural Areas, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Japan
    Am J Surg 203:191-7. 2012
    ..This study was performed to investigate the usefulness of endoscopic ultrasonography (EUS) in comparison with EUS findings before and after CRT, and histologic findings...
  43. ncbi Mesothelin expression correlates with prolonged patient survival in gastric cancer
    Kenji Baba
    Department of Surgical Oncology and Digestive Surgery, Kagoshima University Graduate School, Kagoshima, Japan
    J Surg Oncol 105:195-9. 2012
    ..However, there is no information on mesothelin expression in gastric cancer. The purpose of the current study is to identify the clinical significance of mesothelin in gastric cancer...
  44. ncbi Significance of Twist expression and its association with E-cadherin in esophageal squamous cell carcinoma
    Ken Sasaki
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
    J Exp Clin Cancer Res 28:158. 2009
    ..The purpose of this study is to evaluate the clinical significance of Twist and E-cadherin expression in ESCC...
  45. ncbi Clinical significance of CEA-mRNA expression in peritoneal lavage fluid from patients with gastric cancer
    Koki Tokuda
    First Department of Surgery, Kagoshima University School of Medicine, Kagoshima 890-8520, Japan
    Int J Mol Med 11:79-84. 2003
    ..Adjuvant therapy may be advisable for the gastric cancer patients with positive findings of peritoneal lavage by RT-PCR...
  46. ncbi A multicenter phase II study of biweekly paclitaxel and S-1 combination chemotherapy for unresectable or recurrent gastric cancer
    Akihiro Nakajo
    Department of Surgical Oncology and Digestive Surgery, Kagoshima University Graduate School of Medicine, Kagoshima, Japan
    Cancer Chemother Pharmacol 62:1103-9. 2008
    ..The maximum tolerated dose for this regimen had been established previously in a Phase I study performed in Japanese patients...
  47. ncbi Bone marrow micrometastasis detected by RT-PCR in esophageal squamous cell carcinoma
    Shoji Natsugoe
    First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
    Oncol Rep 10:1879-83. 2003
    ..0% and 47.3%, respectively. Recurrence and survival rates were poorer in patients with RT-PCR positivity, although the differences were not significant. A larger study is required to clarify the clinical impact of BMM...
  48. ncbi Multiple primary carcinomas with esophageal squamous cell cancer: clinicopathologic outcome
    Shoji Natsugoe
    Department of Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, 890 8520 Kagoshima, Japan
    World J Surg 29:46-9. 2005
    ..0005). Meticulous follow-up after treatment of a first cancer should be required to detect other early-stage carcinomas...
  49. ncbi Clinical significance of circulating tumor cells in blood by molecular detection and tumor markers in esophageal cancer
    Saburo Nakashima
    First Department of Surgery, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
    Surgery 133:162-9. 2003
    ..CONCLUSIONS: CEA mRNA detected by RT-PCR was more predictive of tumor recurrence than serum tumor markers. Effective adjuvant therapy is recommended for patients with CEA mRNA positive expression...
  50. ncbi Expression of B7-H4 in blood of patients with gastric cancer predicts tumor progression and prognosis
    Takaaki Arigami
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Surg Oncol 102:748-52. 2010
    ..Here, we assessed B7-H4 expression in blood of patients with gastric cancer to determine whether or not it can predict tumor progression and prognosis...
  51. ncbi Expression of p53R2 is related to prognosis in patients with esophageal squamous cell carcinoma
    Hiroshi Okumura
    Department of Surgical Oncology and Digestive Surgery, Graduate School of Medicine, Kagoshima University, Sakuragaoka, Kagoshima, Japan
    Clin Cancer Res 12:3740-5. 2006
    ..In the present study, we analyzed the expression and clinicopathologic significance of p53 and p53R2 in esophageal squamous cell carcinoma...
  52. ncbi alpha-catenin is a significant prognostic factor than E-cadherin in esophageal squamous cell carcinoma
    Tetsuro Setoyama
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University, Graduate School of Medical and Dental Science, Sakuragaoka, Kagoshima, Japan
    J Surg Oncol 95:148-55. 2007
    ..The purpose of the present study was to analyze clinicopathologic variables in esophageal squamous cell carcinoma (ESCC) according to expression of E-cadherin and alpha-catenin which play an important role in cell adhesion...
  53. ncbi Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma
    Yasuto Uchikado
    Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Clin Cancer Res 11:1174-80. 2005
    ..The purpose of the present study was to evaluate the clinical significance of E-cadherin and Slug expression in ESCC...
  54. ncbi Expression of CXCL12 and its receptor CXCR4 correlates with lymph node metastasis in submucosal esophageal cancer
    Ken Sasaki
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Surg Oncol 97:433-8. 2008
    ..We examined their expression and microvessel density (MVD) in submucosal esophageal squamous cell carcinoma (ESCC) and analyzed their connection to clinicopathological findings including lymph node micrometastasis (LMM)...
  55. ncbi Clinical significance of the B7-H4 coregulatory molecule as a novel prognostic marker in gastric cancer
    Takaaki Arigami
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    World J Surg 35:2051-7. 2011
    ..In the present study, we analyzed B7-H4 expression and the relationship between its expression and clinicopathological factors including prognosis in gastric cancer...
  56. ncbi Clinical implications of N-cadherin expression in gastric cancer
    Takahito Kamikihara
    Digestive Surgery, Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan
    Pathol Int 62:161-6. 2012
    ..However, neo N-cadherin expression significantly affected patient's survival in gastric cancer. Therefore, we concluded that neo N-cadherin expression may be a useful prognostic marker independent of E-cadherin expression...
  57. ncbi Snail plays a key role in E-cadherin-preserved esophageal squamous cell carcinoma
    Shoji Natsugoe
    Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    Oncol Rep 17:517-23. 2007
    ..035). Snail appears to play a key role in preserved E-cadherin expression. Further studies on other molecules in the pathways related to reduced E-cadherin expression in ESCC from the view-point of EMT are necessary...
  58. ncbi Nuclear expression of 14-3-3 sigma is related to prognosis in patients with esophageal squamous cell carcinoma
    Hiroshi Okumura
    Department of Surgical Oncology, Graduate School of Medicine, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Anticancer Res 30:5175-9. 2010
    ..The 14-3-3 sigma gene is transcriptionally activated by p53 after DNA damage and facilitates DNA repair during G2 arrest. The present study analyzed the clinical significance of 14-3-3 sigma expression in esophageal squamous cell carcinoma...
  59. ncbi A phase I combination chemotherapy study of biweekly paclitaxel and S-1 administration in patients with advanced gastric cancer
    Shuichi Hokita
    First Department of Surgery School of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 8900075, Japan
    Cancer Chemother Pharmacol 57:736-40. 2006
    ..Biweekly paclitaxel/S-1 combination chemotherapy could be safely used for the treatment of advanced gastric cancer. The recommended doses for a phase II study with paclitaxel and S-1 are 120 mg/m2 and 80 mg/m2, respectively...
  60. ncbi Is delayed liver resection appropriate for patients with metachronous colorectal metastases?
    Shinichi Ueno
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medicine and Dental Sciences, Kagoshima, Japan
    Ann Surg Oncol 18:1104-9. 2011
    ..e., delayed resection) following initial detection of hepatic lesions from the viewpoints of (1) detection of new metastases during this interval and (2) postoperative outcome...
  61. ncbi Clinical course and outcome after esophagectomy with three-field lymphadenectomy in esophageal cancer
    Shoji Natsugoe
    Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    Langenbecks Arch Surg 395:341-6. 2010
    ..Esophagectomy with three-field lymphadenectomy has been performed for esophageal cancer. Detailed analysis of cause of death and mode of recurrence is required to determine the need for further adjuvant therapy and follow-up...
  62. ncbi Biological properties of biopsy specimens are useful for predicting lymph node micrometastasis in esophageal carcinoma
    Saburo Nakashima
    First Department of Surgery, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
    Anticancer Res 22:2951-6. 2002
    ..CONCLUSION: The expression of CD1 and DG1 in biopsy specimens may offer useful information on lymph node metastasis, including MM in esophageal carcinoma...
  63. ncbi Detection of micrometastases in sentinel node navigation surgery for gastric cancer
    Shigehiro Yanagita
    Department of Surgical Oncology, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Surg Oncol 17:203-10. 2008
    ..Here, we described the current status of MM and ITC in the lymph nodes and the SN concept in gastric cancer...
  64. ncbi Molecular detection of free cancer cells in pleural lavage fluid from esophageal cancer patients
    Shoji Natsugoe
    First Department of Surgery, Kagoshima University School of Medicine, Sakuragaoka, Kagoshima 890 8520, Japan
    Int J Mol Med 12:771-5. 2003
    ..Although disease recurred in almost all patients exhibiting CEA-mRNA expression, due to the relatively small sample in the present study the clinical significance must be investigated further in a larger number of patients...
  65. ncbi Clinicopathological and biological characteristics of esophageal squamous cell carcinoma associated with head and neck cancer
    Masataka Matsumoto
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Oncology 67:98-102. 2004
    ..The aim of this study was to clarify clinicopathological and biological characteristics of esophageal squamous cell carcinoma associated with head and neck cancer (HN group)...
  66. ncbi Initial metastatic, including micrometastatic, sites of lymph nodes in esophageal squamous cell carcinoma
    Shoji Natsugoe
    First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
    J Surg Oncol 89:6-11. 2005
    ..It is important to identify the initial lymph node metastasis when performing less invasive surgery. The purpose of the present study was to analyze locations of solitary lymph node metastasis and micrometastasis in esophageal carcinoma...
  67. ncbi Area of nodal metastasis and radioisotope uptake in sentinel nodes of upper gastrointestinal cancer
    Hideo Arima
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University School of Medical and Dental Science, Kagoshima, Japan
    J Surg Res 135:250-4. 2006
    ..As few studies have examined relationships between metastatic area and radioisotope uptake in sentinel nodes, the present study examined this relationship for gastric and esophageal cancers...
  68. ncbi Strong Smad4 expression correlates with poor prognosis after surgery in patients with hepatocellular carcinoma
    Kiyokazu Hiwatashi
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medicine and Dental Sciences, Kagoshima, Japan
    Ann Surg Oncol 16:3176-82. 2009
    ..The Smad4 protein is the downstream mediator of TGF-beta. In this study, we examined the relationship between Smad4 expression and clinicopathological features in patients with hepatocellular carcinoma (HCC)...
  69. ncbi Clinical and pathological features in T-cell gastric lymphoma associated with human T-cell leukemia virus type 1 (HTLV-1) in comparison with B-cell gastric lymphoma
    Sumiya Ishigami
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Hepatogastroenterology 49:1737-41. 2002
    ..We investigated clinical features of T-cell gastric lymphomas associated with human T-cell leukemia virus type 1 (HTLV-1)...
  70. ncbi Smad4 and transforming growth factor beta1 expression in patients with squamous cell carcinoma of the esophagus
    Shoji Natsugoe
    First Department of Surgery, School of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Clin Cancer Res 8:1838-42. 2002
    ..The present study analyzed the expression and clinicopathological significance of Smad4 and TGF-beta1 in squamous cell carcinoma of the esophagus...
  71. ncbi Clinical impact of micrometastasis of the lymph node in gastric cancer
    Sumiya Ishigami
    First Department of Surgery, Kogoshima University School of Medicine, Kagoshima, Japan
    Am Surg 69:573-7. 2003
    ..05). Based on the present results the presence of lymph node micrometastasis may provide a more accurate indication for surgical outcome in gastric cancer patients at the same clinical stage...
  72. ncbi Lymph node micrometastasis and lymphatic mapping determined by reverse transcriptase-polymerase chain reaction in pN0 gastric carcinoma
    Masataka Matsumoto
    First Department of Surgery, Kagoshima University School of Medicine, Japan
    Surgery 131:630-5. 2002
    ..CONCLUSIONS: We demonstrated the relationship between LMM and clinicopathologic factors, especially in pT1 tumor. The mapping of LMM may prove useful for selecting the optimal treatment...
  73. ncbi Evaluation of sentinel node concept in gastric cancer based on lymph node micrometastasis determined by reverse transcription-polymerase chain reaction
    Takaaki Arigami
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Ann Surg 243:341-7. 2006
    ..To determine the adequacy of sentinel node (SN) concept based on micrometastasis using immunohistochemistry (IHC) and reverse transcription-polymerase chain reaction (RT-PCR) in gastric cancer...
  74. ncbi A case of leptomeningeal carcinomatosis from esophageal basaloid carcinoma diagnosed by quantitative reverse transcription-polymerase chain reaction for carcinoembryonic antigen
    Hiroshi Okumura
    Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
    J Gastroenterol 40:87-93. 2005
    ....
  75. ncbi P53 and MIB-1 expression in gastrointestinal stromal tumor (GIST) of the stomach
    Yoichi Hata
    First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
    Hepatogastroenterology 53:613-5. 2006
    ..Especially, p53 expression of the tumor may indicate patients having a high risk of recurrence...
  76. ncbi B7-H3 expression in gastric cancer: a novel molecular blood marker for detecting circulating tumor cells
    Takaaki Arigami
    Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Cancer Sci 102:1019-24. 2011
    ..02). Multivariate analysis demonstrated that B7-H3 expression was an independent prognostic factor (P = 0.046). Our results indicate that B7-H3 appears to be a useful blood marker for predicting tumor progression in gastric cancer...
  77. ncbi Oncoplastic surgery for Japanese patients with ptotic breasts
    Yuko Kijima
    Department of Surgical Oncology, Breast and Endocrine Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    Breast Cancer 18:273-81. 2011
    ..We report the results of oncoplastic surgery for Japanese patients with early breast cancer in the lateral quadrant area...
  78. ncbi Preoperative segmentation of the liver, based on 3D CT images, facilitates laparoscopic anatomic hepatic resection for small nodular hepatocellular carcinoma in patients with cirrhosis
    Shinichi Ueno
    Department of Surgical Oncology and Digestive Surgery, Kagoshima University Graduate School of Medicine and Dental Sciences, Kagoshima, Japan
    Hepatogastroenterology 57:807-12. 2010
    ..Because anatomic hepatic resection for small HCC yielded more favorable results than non-anatomic resection, we conducted laparoscopic anatomic hepatic resection as image-navigated surgery by referring to portal 3D images...
  79. ncbi Prognostic factors in patients with submucosal esophageal cancer
    Shoji Natsugoe
    First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
    J Gastrointest Surg 8:631-5. 2004
    ....
  80. ncbi Clinical significance of nuclear expression of spleen tyrosine kinase (Syk) in gastric cancer
    Hiroshi Nakashima
    Department of Surgical Oncology and Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Cancer Lett 236:89-94. 2006
    ..Loss of Syk expression was closely related to the malignant property of gastric cancer in the context of tumor depth and lymph node metastasis, especially in early gastric cancer...
  81. ncbi Safety and efficacy of early postoperative hyperbaric oxygen therapy with restriction of transfusions in patients with HCC who have undergone partial hepatectomy
    Shinichi Ueno
    Department of Surgical Oncology and Digestive Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    Langenbecks Arch Surg 396:99-106. 2011
    ..The aim of the present study was to assess the usefulness of acute HBOT after liver resection for patients with HCC in order to minimize the requirement for perioperative blood transfusions...
  82. ncbi Successfully treated metachronous liver metastasis of alpha-fetoprotein-producing early gastric cancer: case report
    Satoshi Akune
    First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
    Hepatogastroenterology 51:919-20. 2004
    ..The assessment of serum alpha-fetoprotein level may be useful for detecting and monitoring liver metastasis in gastric cancer, especially for alpha-fetoprotein-producing tumors...
  83. ncbi Evaluation of colloid size for sentinel nodes detection using radioisotope in early gastric cancer
    Yoshikazu Uenosono
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, 890 8520, Kagoshima, Japan
    Cancer Lett 200:19-24. 2003
    ..At least one lymph node metastasis, including micrometastasis, was included in the hot nodes. RI-labeled colloid size was one of the important factors to detect SN in early gastric cancer...
  84. ncbi Clinical merit of subdividing gastric cancer according to invasion of the muscularis propria
    Sumiya Ishigami
    First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
    Hepatogastroenterology 51:869-71. 2004
    ..However, some mp gastric cancer patients have a good postoperative course, similar to that of early gastric cancer patients. We performed a retrospective analysis of 74 patients with mp gastric cancer, based on the depth of mp invasion...
  85. ncbi Immediate reconstruction using thoracodorsal adipofascial flap after partial mastectomy
    Yuko Kijima
    Department of Surgical Oncology, Breast and Endocrine Surgery, Kagoshima University Graduate School of Medical and Dental Sciences 8 35 1, Sakuragaoka, Kagoshima, Japan
    Breast 18:126-9. 2009
    ..Here, we describe a simple technique for reconstruction of the defect on the outer upper part of the breast with early breast cancer using thoracodorsal adipofascial flap...
  86. ncbi Immediate reconstruction using a modified thoracodorsal adipofascial cutaneous flap after partial mastectomy
    Yuko Kijima
    Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences 8 35 1, Sakuragaoka, Kagoshima 890 8520, Japan
    Breast 20:464-7. 2011
    ..A C-shaped flap containing a crescent of de-epithelialized skin composed of subcutaneous fat and the fascia of the latissimus dorsi muscle is then rotated, gathered, and inset into the breast defect...
  87. ncbi [Radiation therapy leading to complete response of residual lymph node metastasis in advanced gastric cancer.]
    Sumiya Ishigami
    Dept. of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University
    Gan To Kagaku Ryoho 32:2105-7. 2005
    ..Therefore, our case suggests that postoperative radiation therapy can be a useful tool for treatment of residual lymph node metastasis in gastric cancer...
  88. ncbi Reconstruction of recurrent laryngeal nerve with involvement by metastatic node in esophageal cancer
    Shoji Natsugoe
    Department of Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
    Ann Thorac Surg 79:1886-9. 2005
    ..We evaluated recurrent laryngeal nerve reconstruction in patients with lymph node metastasis infiltrating the recurrent laryngeal nerve...
  89. ncbi [A case of advanced rectal carcinoma, preoperative chemo-radiation therapy leading to histological complete response]
    Sumiya Ishigami
    Surgical Dept. of Saiseikai Sendai Hospital
    Gan To Kagaku Ryoho 33:1345-8. 2006
    ..Once complete regression of the rectal cancer by chemo-radiation therapy has been achieved, relapse of the tumor was reported to be rare. Preoperative chemo-radiation therapy is an effective tool to control the advanced rectal cancer...
  90. ncbi Clinical implications of intratumoral dendritic cell infiltration in esophageal squamous cell carcinoma
    Sumiya Ishigami
    First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
    Oncol Rep 10:1237-40. 2003
    ..6, p=0.02), next to nodal involvement, depth of invasion and clinical stage. Being closely related to clinical features, the prognosis of patients with esophageal cancer may be estimated by monitoring IDCI...
  91. ncbi [Combination chemotherapy study of biweekly paclitaxel and S-1 administration in patients with advanced gastric cancer]
    Shuichi Hokita
    Dept of Surgery, Imamura Hospital, Japan
    Gan To Kagaku Ryoho 33:95-8. 2006
    ..This combined therapy represents a novel and active treatment regimen with low toxicity and can be defined as safe and effective. Now we are analyzing the result of the phase II study...
  92. ncbi The comparison of the prognosis between Epstein-Barr virus (EBV)-positive gastric carcinomas and EBV-negative ones
    Yuko Kijima
    Department of Surgical Oncology and Digestive Surgery, Kagoshima University, 8 35 1 Sakuragaoka, 890 8520, Kagoshima, Japan
    Cancer Lett 200:33-40. 2003
    ..These findings suggest that the infiltration of lymphocytes in the EBV-positive GC does not necessarily meant better prognosis and that the EBV status is not a significant prognostic factor in the patients with gastric cancer...
  93. ncbi [A case of advanced gastric cancer with multiple liver metastases completely responding to combination of paclitaxel and S-1]
    Sumiya Ishigami
    Dept of Surgical Oncology, Digestive Surgery Kagoshima University School of Medicine
    Gan To Kagaku Ryoho 35:1197-9. 2008
    ..She has been well without tumor re-growth for 4 years. The combination of PTX and S-1 may be an effective regimen for gastric cancer with liver metastases...
  94. ncbi [A case of advanced type 4 gastric cancer with peritonitis dissemination, navel metastasis effectively treated with combined chemotherapy of biweekly paclitaxel (TXL) and TS-1]
    Shuichi Hokita
    First Dept. of Surgery, School of Medicine, Kagoshima University
    Gan To Kagaku Ryoho 30:1343-6. 2003
    ..There was no findings of recurrence 5 months later. Biweekly TXL and TS-1 therapy was thought to be an effective chemotherapy against advanced gastric cancer...
  95. ncbi [A case of successful treatment by low-dose 5-fluorouracil and cisplatin for liver metastases of esophageal adenosquamous carcinoma]
    Yasuto Uchikado
    Dept. of Surgical Oncology, Graduate School of Medicine, Kagoshima University
    Gan To Kagaku Ryoho 33:83-5. 2006
    ..After 6 courses of chemotherapy, no liver metastases were detected. Based on the present findings, we recommend low-dose 5-fluorouracil/cisplatin therapy for liver metastasis from esophageal adenosquamous carcinoma...
  96. ncbi [Clinical impact of the Guidelines for Treatment of Gastric Cancer]
    Sumiya Ishigami
    Department of Surgical Oncology, Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics Kagoshima University Graduate School of Medicine and Dental Sciences, Kagoshima, Japan
    Nihon Geka Gakkai Zasshi 108:253-8. 2007
    ..Japanese physicians have a responsibility to contribute to the evidence for gastric cancer treatment to be considered worldwide. In the near future, a simpler, more easily understandable revision of the TGGC will be necessary...