Akio Inui

Summary

Affiliation: Kagoshima University
Country: Japan

Publications

  1. ncbi request reprint [Ghrelin-neuropeptide Y axis in the control of feeding and gastrointestinal motility]
    Akio Inui
    Nihon Yakurigaku Zasshi 127:83-7. 2006
  2. ncbi request reprint Histologic diagnosis and management of hypothalamic tumors in children by the use of newly developed flexible neuroendoscopes
    Shuji Kamikawa
    Department of Neurosurgery, Kobe Children s Hospital, Kobe, Japan
    Int J Oncol 22:269-72. 2003
  3. pmc Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats
    Kazunori Fujino
    Department of Surgery, Shiga University of Medical Science, Otsu, Japan
    J Physiol 550:227-40. 2003
  4. ncbi request reprint Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
    Hiroshi Inoue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Cell Metab 3:267-75. 2006
  5. ncbi request reprint Ghrelin concentrations and cardiac vagal tone are decreased after pharmacologic and cognitive-behavioral treatment in patients with bulimia nervosa
    Muneki Tanaka
    Department of Psychosomatic Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Horm Behav 50:261-5. 2006
  6. pmc Role of musclin in the pathogenesis of hypertension in rat
    Ying xiao Li
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    PLoS ONE 8:e72004. 2013
  7. pmc Stimulation of leptin secretion by insulin
    Minglun Tsai
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Indian J Endocrinol Metab 16:S543-8. 2012
  8. pmc Silymarin induces insulin resistance through an increase of phosphatase and tensin homolog in Wistar rats
    Kai Chun Cheng
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    PLoS ONE 9:e84550. 2014
  9. pmc Cancer cachexia--pathophysiology and management
    Hajime Suzuki
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    J Gastroenterol 48:574-94. 2013
  10. pmc Kobe earthquake and post-traumatic stress in school-aged children
    Masaharu Uemoto
    Kobe City College of Nursing, 3 4 Gakuen nishi machi, Nishi ku, Kobe City, Japan
    Int J Behav Med 19:243-51. 2012

Collaborators

Detail Information

Publications108 found, 100 shown here

  1. ncbi request reprint [Ghrelin-neuropeptide Y axis in the control of feeding and gastrointestinal motility]
    Akio Inui
    Nihon Yakurigaku Zasshi 127:83-7. 2006
  2. ncbi request reprint Histologic diagnosis and management of hypothalamic tumors in children by the use of newly developed flexible neuroendoscopes
    Shuji Kamikawa
    Department of Neurosurgery, Kobe Children s Hospital, Kobe, Japan
    Int J Oncol 22:269-72. 2003
    ..The relatively non-invasive approach reported here would represent a significant technical advance in the diagnosis and management of hypothalamic and other ventricular tumors...
  3. pmc Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats
    Kazunori Fujino
    Department of Surgery, Shiga University of Medical Science, Otsu, Japan
    J Physiol 550:227-40. 2003
    ..The action of ghrelin to induce fasted motor activity is strongly affected by intragastric pH; low pH inhibits the action...
  4. ncbi request reprint Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
    Hiroshi Inoue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Cell Metab 3:267-75. 2006
    ..These results thus indicate that IL-6-STAT3 signaling in the liver contributes to insulin action in the brain, leading to the suppression of hepatic glucose production...
  5. ncbi request reprint Ghrelin concentrations and cardiac vagal tone are decreased after pharmacologic and cognitive-behavioral treatment in patients with bulimia nervosa
    Muneki Tanaka
    Department of Psychosomatic Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Horm Behav 50:261-5. 2006
    ....
  6. pmc Role of musclin in the pathogenesis of hypertension in rat
    Ying xiao Li
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    PLoS ONE 8:e72004. 2013
    ..The higher expression of musclin in hypertension indicates that musclin could be used as a new target for the treatment of hypertension in the future. ..
  7. pmc Stimulation of leptin secretion by insulin
    Minglun Tsai
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Indian J Endocrinol Metab 16:S543-8. 2012
    ..Understanding the mechanism of insulin-regulated leptin secretion could lead to the development of new treatment methods for obesity and its comorbidities, which are serious public health concerns...
  8. pmc Silymarin induces insulin resistance through an increase of phosphatase and tensin homolog in Wistar rats
    Kai Chun Cheng
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    PLoS ONE 9:e84550. 2014
    ..Silymarin is the active ingredient in milk thistle and exerts numerous effects through the activation of PTEN. However, the effect of silymarin on the development of insulin resistance remains unknown...
  9. pmc Cancer cachexia--pathophysiology and management
    Hajime Suzuki
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    J Gastroenterol 48:574-94. 2013
    ..While there has been great progress in understanding the underlying biological mechanisms of cachexia, health care providers must also recognize the psychosocial and biomedical impact cachexia can have...
  10. pmc Kobe earthquake and post-traumatic stress in school-aged children
    Masaharu Uemoto
    Kobe City College of Nursing, 3 4 Gakuen nishi machi, Nishi ku, Kobe City, Japan
    Int J Behav Med 19:243-51. 2012
    ..The psychological reactions to catastrophic events are not known well in children...
  11. pmc The clinical use of Kampo medicines (traditional Japanese herbal treatments) for controlling cancer patients' symptoms in Japan: a national cross-sectional survey
    Satoru Iwase
    Department of Palliative Medicine, The University of Tokyo Hospital, 7 3 1Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    BMC Complement Altern Med 12:222. 2012
    ..We aimed to investigate physicians' recognition of Kampo medicines and their clinical use for cancer patients in the field of palliative care...
  12. doi request reprint Plasma klotho levels decrease in both anorexia nervosa and obesity
    Marie Amitani
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Nutrition 29:1106-9. 2013
    ..The aim of this study was to examine the associations of klotho with body mass index (BMI) in patients with restricting-type anorexia nervosa (r-AN) and obesity...
  13. doi request reprint The role of adiponectin multimers in anorexia nervosa
    Haruka Amitani
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Nutrition 29:203-6. 2013
    ..Therefore, we measured plasma adiponectin and its isoforms levels in patients with AN to examine their roles in AN...
  14. doi request reprint Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice
    Kaori Atsuchi
    Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Neuroreport 21:1008-11. 2010
    ..We found that centrally administered nesfatin-1 decreased food intake and inhibited gastroduodenal motility in mice. These results suggest that nesfatin-1 influences gut motility and feeding behaviour...
  15. doi request reprint Regulatory effects of Y4 receptor agonist (BVD-74D) on food intake
    Jiang Bo Li
    Division of Psychosomatic Internal Medicine, Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    Peptides 31:1706-10. 2010
    ..These findings indicate that the Y4 receptor and its agonist would be promising targets for obesity...
  16. doi request reprint Ghrelin family of peptides and gut motility
    Akihiro Asakawa
    Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Gastroenterol Hepatol 26:73-4. 2011
    ..Increasing knowledge of the effects of ghrelin family of peptides on gastrointestinal motility could lead to innovative new therapies for functional gastrointestinal disorders...
  17. doi request reprint Characterization of preptin-induced insulin secretion in pancreatic β-cells
    Kai Chun Cheng
    Department of Psychosomatic Internal Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    J Endocrinol 215:43-9. 2012
    ..Our results provide new insight into the insulin secretion of preptin, a secreted proIGF2-derived peptide that can induce greater efficacy of signal transduction resulting from PLC and PKC activation through the IGF2R...
  18. doi request reprint Parathyroid hormone-related protein has an anorexigenic activity via activation of hypothalamic urocortins 2 and 3
    Akihiro Asakawa
    Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
    Psychoneuroendocrinology 35:1178-86. 2010
    ..Our findings suggest that PTHrP influences the food intake and body weight; therefore, PTHrP can be considered as a therapeutic target for cancer cachexia...
  19. ncbi request reprint Zinc as an appetite stimulator - the possible role of zinc in the progression of diseases such as cachexia and sarcopenia
    Hajime Suzuki
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, 890 8520, Japan
    Recent Pat Food Nutr Agric 3:226-31. 2011
    ..The article also presents some promising patents on zinc...
  20. pmc Hydrogen improves glycemic control in type1 diabetic animal model by promoting glucose uptake into skeletal muscle
    Haruka Amitani
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    PLoS ONE 8:e53913. 2013
    ..Our study demonstrates that H(2) exerts metabolic effects similar to those of insulin and may be a novel therapeutic alternative to insulin in type 1 diabetes mellitus that can be administered orally...
  21. doi request reprint Intelligence quotient and cognitive functions in severe restricting-type anorexia nervosa before and after weight gain
    Ken Ichiro Koyama
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Nutrition 28:1132-6. 2012
    ..The present study investigated the overall intelligence quotient (IQ) scores and cognitive functions of patients with AN-R...
  22. ncbi request reprint Failure of the feeding response to fasting in carnitine-deficient juvenile visceral steatosis (JVS) mice: involvement of defective acyl-ghrelin secretion and enhanced corticotropin-releasing factor signaling in the hypothalamus
    Takeo Sakoguchi
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8544, Japan
    Biochim Biophys Acta 1792:1087-93. 2009
    ..In this animal model, carnitine normalizes the feeding response through an inhibition of CRF...
  23. ncbi request reprint Obestatin, acyl ghrelin, and des-acyl ghrelin responses to an oral glucose tolerance test in the restricting type of anorexia nervosa
    Toshiro Harada
    Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima City, Japan
    Biol Psychiatry 63:245-7. 2008
    ..We investigated simultaneously obestatin, acyl ghrelin, and des-acyl ghrelin in the restricting type of anorexia nervosa (AN-R) patients...
  24. ncbi request reprint Cachexia and herbal medicine: perspective
    Hajime Suzuki
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    Curr Pharm Des 18:4865-88. 2012
    ..The review gives perspective on a new horizon for herbal medicine from a scientific point of view and a basis for the further development of complementary and alternative medicine (CAM) for patients...
  25. doi request reprint Ghrelin and cachexia in chronic kidney disease
    Hajime Suzuki
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    Pediatr Nephrol 28:521-6. 2013
    ..Further evaluation of this appetite-regulating hormone in CKD is needed to confirm previous findings and to determine the underlying mechanisms...
  26. doi request reprint Cancer cachexia pathophysiology and translational aspect of herbal medicine
    Hajime Suzuki
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    Jpn J Clin Oncol 43:695-705. 2013
    ..Mechanistic studies and identification of active compounds could lead to new discoveries in biological and biomedical sciences. ..
  27. doi request reprint Opioid μ-receptors as new target for insulin resistance
    Kai Chun Cheng
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890 8520, Japan
    Pharmacol Ther 139:334-40. 2013
    ..In the present review, we update these topics and discuss the concept of targeting peripheral MOR pathway for the treatment of insulin resistance. ..
  28. doi request reprint Plasma nesfatin-1 concentrations in restricting-type anorexia nervosa
    Kazuma Ogiso
    Division of Psychosomatic Internal Medicine, Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Peptides 32:150-3. 2011
    ..17 ± 55.95 fmol/ml vs. 107.34 ± 40.63 fmol/ml, P<0.05). Although AN-R is associated with emaciation for a prolonged period, our result suggested that nesfatin-1 levels may be regulated by nutrition status and response to starvation...
  29. doi request reprint Biological effects of obestatin
    Jiang Bo Li
    Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    Endocrine 39:205-11. 2011
    ..The biological effects of obestatin will be reviewed in this article...
  30. doi request reprint Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2c receptor and acyl ghrelin
    Naoki Fujitsuka
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Biol Psychiatry 65:748-59. 2009
    ..These agents may cause upper gastrointestinal (GI) symptoms that lead to their discontinuation. We examined whether SSRIs modify physiologic GI motor activities in freely moving rats...
  31. doi request reprint Comparison of the anorexigenic activity of CRF family peptides
    Chie Tanaka
    Division of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890 8544, Japan
    Biochem Biophys Res Commun 390:887-91. 2009
    ..In addition, repeated administration of Ucn1 lowered blood glucose and acylated ghrelin, and decreased the visceral fat weight of high fat fed obese mice...
  32. ncbi request reprint Control of food intake and muscle wasting in cachexia
    Marie Amitani
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Int J Biochem Cell Biol 45:2179-85. 2013
    ..In this review, we describe recent experimental and clinical studies that have examined the regulation of food intake and muscle wasting in cachexia. This article is part of a Directed Issue entitled: Molecular basis of muscle wasting. ..
  33. ncbi request reprint New method of manometric measurement of gastroduodenal motility in conscious mice: effects of ghrelin and Y2 depletion
    Rumi Tanaka
    Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Am J Physiol Gastrointest Liver Physiol 297:G1028-34. 2009
    ..Our model provides a new method for studies of gastrointestinal motility in various mouse models, including transgenic and knockout ones...
  34. ncbi request reprint Relationship between pretreatment laboratory-measured episodes of reactive hypoglycemia and short-term weight restoration in anorexia nervosa: a preliminary study
    Daisuke Yasuhara
    Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima City 890 8520, Japan
    Psychoneuroendocrinology 31:452-8. 2006
    ....
  35. doi request reprint Ghrelin and anorexia nervosa: a psychosomatic perspective
    Kazuma Ogiso
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
    Nutrition 27:988-93. 2011
    ..In this review, we describe the role of ghrelin in the pathophysiology and potential treatment of AN along the gut-brain axis...
  36. ncbi request reprint The role of zinc in the treatment of taste disorders
    Takakazu Yagi
    Department of Orthodontics, Medical and Dental Hospital, Kagoshima University, Kagoshima, 890 8544, Japan
    Recent Pat Food Nutr Agric 5:44-51. 2013
    ..The article presents some promising patents on the role of zinc in the treatment of taste disorders...
  37. doi request reprint Ghrelin and gastrointestinal movement
    Naoki Fujitsuka
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Methods Enzymol 514:289-301. 2012
    ..These findings suggest that ghrelin can be expected to be a therapeutic target for GI disorders...
  38. doi request reprint Induction of PDK4 in the heart muscle of JVS mice, an animal model of systemic carnitine deficiency, does not appear to reduce glucose utilization by the heart
    Miharu Ushikai
    Department of Molecular Metabolism and Biochemical Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890 8544, Japan
    Mol Genet Metab 102:349-55. 2011
    ..The preferred glucose utilization may be involved in developing cardiac hypertrophy from carnitine deficiency in fatty acid oxidation abnormality...
  39. doi request reprint Centrally administered urocortin 3 inhibits food intake and gastric emptying in mice
    Miharu Ushikai
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Endocrine 39:113-7. 2011
    ..These results indicated that Ucn3 influences feeding behavior and gut motility, and may be a promising therapeutic target in the treatment of eating and functional gastrointestinal disorders...
  40. doi request reprint A case of anorexia nervosa with disseminated intravascular coagulation syndrome
    Izumi Haruta
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Int J Eat Disord 45:453-5. 2012
    ..We think that the prevention of sepsis via bacterial translocation is an important aspect of care for patients with severe AN in addition to the prevention of refeeding syndrome...
  41. doi request reprint Leptin gene therapy in the fight against diabetes
    Yuqing Wang
    Kagoshima University Graduate School of Medical and Dental Sciences, Department of Gene Therapy and Regenerative Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Expert Opin Biol Ther 10:1405-14. 2010
    ..The incidence of diabetes is increasing worldwide, yet current treatments are not always effective for all patient or disease types...
  42. ncbi request reprint Efficacy of ghrelin in cancer cachexia: clinical trials and a novel treatment by rikkunshito
    Naoki Fujitsuka
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890 8520, Japan
    Crit Rev Oncog 17:277-84. 2012
    ..A potentiator of ghrelin signaling such as rikkunshito may represent a novel approach for the treatment of cancer cachexia...
  43. doi request reprint Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice
    Shinya Kojima
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Peptides 30:962-6. 2009
    ..These results show for the first time that one time central leptin gene therapy is effective and durable in reinstating euglycemia and energy homeostasis for extended periods in the absence of insulin...
  44. doi request reprint Ghrelin: a gut hormonal basis of motility regulation and functional dyspepsia
    Kazuma Ogiso
    Department of Psychosomatic Internal Medicine, Kagoshima University of Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Gastroenterol Hepatol 26:67-72. 2011
    ..Altered gut-brain interactions may underlie the symptoms of FD. Ghrelin may be associated with FD through its effect on the regulation of gut motility. Further studies are needed to examine the effects of ghrelin in FD...
  45. ncbi request reprint A role for pancreatic polypeptide in feeding and body weight regulation
    Shinya Kojima
    Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1, Sakuragaoka, Kagoshima City 890 8520, Japan
    Peptides 28:459-63. 2007
    ....
  46. ncbi request reprint Incomplete restoration of the secretion of ghrelin and PYY compared to insulin after food ingestion following weight gain in anorexia nervosa
    Toshihiro Nakahara
    Department of Behavioral Medicine, Kagoshima University, Graduate School of Medical and Dental Sciences, 8 35 1, Sakuragaoka, Kagoshima City 890 8520, Japan
    J Psychiatr Res 41:814-20. 2007
    ..We investigated pre- and postprandial responses of ghrelin and PYY in anorexia nervosa (AN) and the influence of weight gain...
  47. ncbi request reprint Plasma obestatin concentrations are negatively correlated with body mass index, insulin resistance index, and plasma leptin concentrations in obesity and anorexia nervosa
    Toshihiro Nakahara
    Department of Psychosomatic Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, Kagoshima City, Japan
    Biol Psychiatry 64:252-5. 2008
    ..Obestatin is a recently identified ghrelin gene product that was reported to inhibit appetite and gastric motility in contrast to ghrelin. We investigated fasting obestatin and ghrelin levels in patients with obesity and anorexia nervosa...
  48. ncbi request reprint The role of ghrelin in energy homeostasis and its potential clinical relevance (Review)
    Kai Chun Cheng
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, Japan
    Int J Mol Med 26:771-8. 2010
    ..The broad spectrum of biological activities associated with ghrelin continues to expand. In the future, the diverse functions of ghrelin raise the possibility of its clinical application in a large number of pathological conditions...
  49. pmc The role of ghrelin, salivary secretions, and dental care in eating disorders
    Takakazu Yagi
    Department of Orthodontics, Medical and Dental Hospital, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    Nutrients 4:967-89. 2012
    ..This review discusses the pharmacological potential of ghrelin in regulating food-intake and the role of saliva and oral care in young patients with eating disorders...
  50. pmc The role of leptin in the control of insulin-glucose axis
    Marie Amitani
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima, Japan
    Front Neurosci 7:51. 2013
    ..Herein, we review the role of leptin in regulating feeding behavior and glucose metabolism and also the therapeutic potential of leptin in obesity and diabetes mellitus...
  51. ncbi request reprint Glucose tolerance predicts short-term refeeding outcome in females with anorexia nervosa
    Daisuke Yasuhara
    Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima City, Japan
    Psychosom Med 67:669-76. 2005
    ....
  52. pmc Long-term correction of type 1 and 2 diabetes by central leptin gene therapy independent of effects on appetite and energy expenditure
    Masako Nakano
    Department of Social and Behavioral Medicine, Kagoshima University Graduate Medical and Dental Sciences, Kagoshima, Japan
    Indian J Endocrinol Metab 16:S556-61. 2012
    ..In this article, the information has been assembled from published review articles on this topic...
  53. doi request reprint Effects of supplementation on food intake, body weight and hepatic metabolites in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse model of human citrin deficiency
    Takeyori Saheki
    Institute of Resource Development and Analysis, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Mol Genet Metab 107:322-9. 2012
    ....
  54. ncbi request reprint Pathogenesis and treatment of eating disorders associated with type 1 diabetes mellitus
    Daisuke Yasuhara
    Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Nat Clin Pract Endocrinol Metab 3:612-3. 2007
  55. ncbi request reprint [Recent development in research and management of cancer anorexia-cachexia syndrome]
    Akio Inui
    Dept of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
    Gan To Kagaku Ryoho 32:743-9. 2005
    ..Because weight loss shortens the survival time of cancer patients and decreases performance status, effective therapy would extend patient survival and improve quality of life...
  56. doi request reprint Ghrelin gene products and the regulation of food intake and gut motility
    Chih Yen Chen
    Faculty of Medicine, National Yang Ming University School of Medicine, Taipei, Japan
    Pharmacol Rev 61:430-81. 2009
    ..GOAT may provide a critical molecular target in developing novel therapeutics for obesity and type 2 diabetes...
  57. ncbi request reprint Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice
    Naohiko Ueno
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University, Kobe, Japan
    Peptides 27:2332-42. 2006
    ....
  58. ncbi request reprint Inhibitory effect of 5-hydroxytryptamine on hyperphagia in mice with genetic overexpression of neuropeptide Y
    Sheng Huang Hsiao
    Department of Neurosurgery, Taiepi City Hospital, Taipei City 10601, Taiwan
    Neurosci Lett 394:256-8. 2006
    ..In conclusion, 5-HT reduces hyperphagia in the NPY-overexpressing rat through action on 5-HT2A receptors and this hypophagic effect of 5-HT does not depend on the hyperglycemia...
  59. ncbi request reprint Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats
    Chih Yen Chen
    Division of Gastroenterology, Taipei Veterans General Hospital, Taiwan
    Gastroenterology 129:8-25. 2005
    ..Although it has been shown that des-acyl ghrelin decreases food intake and gastric emptying, no previous studies have examined the effects of des-acyl ghrelin on physiologic fed and fasted motor activity in the gastrointestinal tract...
  60. ncbi request reprint Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy
    Naohiko Ueno
    Department of Neuroscience, McKnight Brain Institute, P O Box 100244, Gainesville, Florida 32610 0244, USA
    Endocrinology 145:4176-84. 2004
    ..Cumulatively, these results identify newer central and peripheral modulatory influences of leptin on hormonal signals of disparate origin implicated in weight homeostasis and metabolic disorders...
  61. ncbi request reprint Gene expression profiles post Roux-en-Y gastric bypass
    Yuan Xu
    Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Surgery 136:246-52. 2004
    ..Molecular mechanisms of weight loss after Roux-en-Y gastric bypass (RYGB) were studied by correlating changes in gene expression profiles in hypothalamic arcuate nucleus (ARC) and subcutaneous abdominal fat (SAF)...
  62. ncbi request reprint Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ
    Akio Inui
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    FASEB J 18:439-56. 2004
    ..Defective ghrelin signaling from the stomach could contribute to abnormalities in energy balance, growth, and associated gastrointestinal and neuroendocrine functions...
  63. ncbi request reprint Orexigenic/anorexigenic signals in bulimia nervosa
    Yoshiyuki Takimoto
    Department of Psychosomatic Medicine, Faculty of Medicine, Tokyo University, Tokyo, Japan
    Curr Mol Med 3:349-60. 2003
    ..This report reviews data that point to the hypothesis that dysregulation of monoaminergic and new peptidergic circuitry controlling food intake and energy expenditure play a major role in the eating behavior of BN...
  64. ncbi request reprint Characterization of the effects of pancreatic polypeptide in the regulation of energy balance
    Akihiro Asakawa
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Meidicine, Japan
    Gastroenterology 124:1325-36. 2003
    ..Pancreatic polypeptide (PP) belongs to a family of peptides including neuropeptide Y and peptide YY. We examined the role of PP in the regulation of body weight as well as the therapeutic potential of PP...
  65. ncbi request reprint [Molecular mechanisms and clinical implications for the regulatory feedback loop of feeding and body adiposity]
    Akio Inui
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 100:298-305. 2003
  66. doi request reprint Decreased levels of ghrelin, cortisol, and fasting blood sugar, but not n-octanoylated ghrelin, in Japanese schizophrenic inpatients treated with olanzapine
    Kazuhide Tanaka
    Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1527-32. 2008
    ..Further studies examining the effect of chronic olanzapine administration on weight and energy homeostasis in inpatients are required...
  67. ncbi request reprint Gastrointestinal hormones (anorexigenic peptide YY and orexigenic ghrelin) influence neural tube development
    Hideki Yuzuriha
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    FASEB J 21:2108-12. 2007
    ..The present study is the first linking GI hormones to the leading cause of infant mortality and provides a novel insight for neurogenesis in which materno-fetal communication through GI hormones appears to be important...
  68. ncbi request reprint [Ghrelin and gut motility]
    Akihiro Asakawa
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine
    Nihon Rinsho 62:365-8. 2004
  69. ncbi request reprint Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats
    Ana Guijarro
    Dept of Surgery, University Hospital, 750 East Adams St, Syracuse, NY 13210, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1474-89. 2007
    ..These events override the compensatory response to the drop in leptin levels aimed at conserving energy...
  70. ncbi request reprint Blunted metabolic response to fasting in obese mice
    Naohiko Ueno
    Department of Internal Medicine, Kobe Seaside Hospital, 1 1 28 Isobe dori Chuo ku, Kobe, Hyogo, 651 0084, Japan
    Endocrine 32:192-6. 2007
    ..This data show that obese mice may have decreased sensitivity to fasting-induced increase in circulating ghrelin and their oxygen consumption exhibited a blunted response to fasting...
  71. doi request reprint Obestatin inhibits motor activity in the antrum and duodenum in the fed state of conscious rats
    Koji Ataka
    Research Institute, Taiko Pharmaceutical Co Ltd, Osaka, Japan
    Am J Physiol Gastrointest Liver Physiol 294:G1210-8. 2008
    ..These results suggest that, in the fed state, obestatin inhibits motor activity in the antrum and duodenum and that CRF type 1 and type 2 receptors in the brain might be involved in these effects of obestatin on gastroduodenal motility...
  72. ncbi request reprint Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia
    Mark D DeBoer
    Center for the Study of Weight Regulation, Oregon Health and Science University, 707 SW Gaines Road, Portland, OR 97239, USA
    Endocrinology 148:3004-12. 2007
    ..We conclude that ghrelin and a synthetic ghrelin receptor agonist improve weight gain and lean body mass retention via effects involving orexigenic neuropeptides and antiinflammatory changes...
  73. ncbi request reprint Anorexia in hemodialysis patients: the possible role of des-acyl ghrelin
    Maurizio Muscaritoli
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Am J Nephrol 27:360-5. 2007
    ..The aim of this cross-sectional study is to clarify whether anorexia and body weight change in HD patients relate to plasma des-acyl ghrelin levels...
  74. ncbi request reprint Leptin and gastric neuroendocrine system
    Akio Inui
    Gastroenterology 123:1751. 2002
  75. ncbi request reprint Perioperative plasma active and total ghrelin levels are reduced in acromegaly when compared with in nonfunctioning pituitary tumours even after normalization of serum GH
    Takakazu Kawamata
    Department of Neurosurgery, Tokyo Women s Medical University, Tokyo, Japan
    Clin Endocrinol (Oxf) 67:140-4. 2007
    ..This study investigated dysregulation of ghrelin secretion in acromegaly and its short-term postoperative recovery...
  76. ncbi request reprint Cachexia and obesity: two sides of one coin?
    Akio Inui
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Curr Opin Clin Nutr Metab Care 6:395-9. 2003
    ..It is not well known, however, how these feeding-regulatory molecules are affected in cachexia associated with cancer and other critical conditions in which cytokines such as interleukin-1 and interleukin-6 may have a key role...
  77. ncbi request reprint Intracerebroventricular administration of NPY stimulates resistin gene expression in mice
    Hideki Yuzuriha
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Japan
    Int J Mol Med 11:675-6. 2003
    ..These observations indicate that NPY might have a role in regulating resistin gene expression in WAT and that the novel brain-fat axis might be involved in the pathogenesis of obesity and related diseases...
  78. ncbi request reprint Leptin treatment ameliorates anxiety in ob/ob obese mice
    Akihiro Asakawa
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Hyogo, Japan
    J Diabetes Complications 17:105-7. 2003
    ..2% after treatment. Leptin treatment ameliorated not only obesity but also anxiety in ob/ob mice. Our results indicate that the treatment of obesity may lead to the solution of psychological problems...
  79. ncbi request reprint Obesity--a chronic health problem in cloned mice?
    Akio Inui
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Japan
    Trends Pharmacol Sci 24:77-80. 2003
    ....
  80. ncbi request reprint Cancer anorexia-cachexia syndrome: current issues in research and management
    Akio Inui
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Japan
    CA Cancer J Clin 52:72-91. 2002
    ..Because weight loss shortens the survival time of cancer patients and decreases performance status, effective therapy would extend patient survival and improve quality of life...
  81. ncbi request reprint Paracentral cortical atrophy in patients with eating disorders
    Akio Inui
    Am J Med 112:681-3. 2002
  82. ncbi request reprint Leptin-replacement therapy in lipodystrophy
    Akio Inui
    N Engl J Med 346:2009; author reply 2009-10. 2002
  83. ncbi request reprint Effect of amphetamine repeated treatment on the feeding behavior in neuropeptide Y-overexpressing mice
    Dong Yih Kuo
    Department of Physiology, Chung Shan Medical University, Taichung City, 40201, Taiwan
    Neurosci Lett 329:359-61. 2002
    ..Thus, NPY can be considered to play a functional role in the regulation of AMPH-induced anorexia in mice...
  84. ncbi request reprint Anorexia in space and possible etiologies: an overview
    Monica S Da Silva
    Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, SUNY Upstate Medial University, Syracuse, New York 13210, USA
    Nutrition 18:805-13. 2002
    ....
  85. pmc Ghrelin treatment of chronic kidney disease: improvements in lean body mass and cytokine profile
    Mark D DeBoer
    Department of Pediatrics, University of Virginia, Charlottesville, VA 22908, USA
    Endocrinology 149:827-35. 2008
    ..We conclude that ghrelin treatment in uremia results in improved lean mass accrual in part due to suppressed muscle proteolysis and possibly related to antiinflammatory effects...
  86. ncbi request reprint Ob/ob mice as a model of delayed gastric emptying
    Akihiro Asakawa
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Japan
    J Diabetes Complications 17:27-8. 2003
    ..01). Our results indicate that the ob/ob mice are a useful model not only of glucose intolerance but also of delayed gastric emptying as a diabetic complication...
  87. ncbi request reprint Acute intracerebroventricular administration of either carboxyl-terminal or amino-terminal fragments of agouti-related peptide produces a long-term decrease in energy expenditure in rats
    Kyoko Goto
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
    Int J Mol Med 12:379-83. 2003
    ..This suggests that the amino-terminal region of AgRP plays a regulatory role in energy metabolism...
  88. ncbi request reprint Is obesity an inflammatory disease?
    Eduardo J B Ramos
    Department of Surgery, Management Information and Decision, Clinical Molecular Medicine, SUNY Upstate Medical University, Syracuse University, Syracuse, NY, USA
    Surgery 134:329-35. 2003
    ..Most obese individuals have elevated concentrations of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), markers of inflammation closely associated with diabetes, hypertension, and stroke...
  89. ncbi request reprint Anorexia nervosa and hyperthyroidism
    Akio Inui
    Int J Psychiatry Med 33:181-2. 2003
  90. ncbi request reprint [Feeding-related disorders in medicine, with special reference to cancer anorexia-cachexia syndrome]
    Akio Inui
    Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890 8520
    Rinsho Byori 54:1044-51. 2006
    ..As weight loss shortens the survival time of cancer patients and decreases their performance status, effective therapy would extend patient survival and improve quality of life...
  91. ncbi request reprint Role of leucine in regulating food intake
    Alessandro Laviano
    Science 313:1236-8; author reply 1236-8. 2006
  92. ncbi request reprint Peptide YY3-36 and pancreatic polypeptide suppress food intake
    Akihiro Asakawa
    J Gastroenterol Hepatol 21:1501-2. 2006
  93. ncbi request reprint Increased circulating cholecystokinin contributes to anorexia and anxiety behavior in mice overexpressing pancreatic polypeptide
    Naohiko Ueno
    Department of Internal Medicine, Kobe Seaside Hospital, 1 1 28 Isogami dori, Chuo Ku, Kobe, 651 0084, Japan
    Regul Pept 141:8-11. 2007
    ..These results indicated that elevated CCK may contribute to anorexic and anxious phenotype of PP overexpressing mice...
  94. ncbi request reprint Olanzapine-induced hyperglycemia in anorexia nervosa
    Daisuke Yasuhara
    Am J Psychiatry 164:528-9. 2007
  95. ncbi request reprint Therapy insight: Cancer anorexia-cachexia syndrome--when all you can eat is yourself
    Alessandro Laviano
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Nat Clin Pract Oncol 2:158-65. 2005
    ....
  96. doi request reprint Central prostaglandin D(2) stimulates food intake via the neuropeptide Y system in mice
    Kousaku Ohinata
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto, Japan
    FEBS Lett 582:679-84. 2008
    ..The orexigenic activity of PGD(2) was also abolished by an antagonist for neuropeptide Y (NPY) Y(1) receptor. Taken together, PGD(2) may stimulate food intake through central DP(1) receptor coupled to the NPY system...
  97. ncbi request reprint Branched-chain amino acids: the best compromise to achieve anabolism?
    Alessandro Laviano
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Curr Opin Clin Nutr Metab Care 8:408-14. 2005
    ..More effective therapies are needed to promote appetite and food intake, to preserve lean body mass, and to ameliorate patients' psychological distress...
  98. ncbi request reprint Intracerebroventricularly administered urocortin inhibits gastric emptying in mice
    Toshiaki Nagata
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Int J Mol Med 15:1041-3. 2005
    ..These results suggest that the potent anorectic properties of urocortin may be partly due to the anti-gastroprokinetic activity of the peptide...
  99. ncbi request reprint Melanocortin signalling, single nucleotide polymorphism, and eating disorders
    Akio Inui
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Japan
    Int J Psychiatry Med 34:399-403. 2004