Hisham R Ibrahim

Summary

Affiliation: Kagoshima University
Country: Japan

Publications

  1. ncbi New drug-targeting strategy from beneath the shell of egg
    Hisham R Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890 0065, Japan
    Expert Opin Drug Deliv 7:1145-58. 2010
  2. ncbi Identification of a distinct antibacterial domain within the N-lobe of ovotransferrin
    H R Ibrahim
    Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, Japan
    Biochim Biophys Acta 1401:289-303. 1998
  3. ncbi Human lysozyme possesses novel antimicrobial peptides within its N-terminal domain that target bacterial respiration
    Hisham R Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890 0065, Japan
    J Agric Food Chem 59:10336-45. 2011
  4. ncbi Novel anticancer activity of the autocleaved ovotransferrin against human colon and breast cancer cells
    Hisham R Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima, Japan
    J Agric Food Chem 57:11383-90. 2009
  5. ncbi Ovotransferrin possesses SOD-like superoxide anion scavenging activity that is promoted by copper and manganese binding
    Hisham R Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890 0065, Japan
    Int J Biol Macromol 41:631-40. 2007
  6. ncbi Ovotransferrin is a redox-dependent autoprocessing protein incorporating four consensus self-cleaving motifs flanking the two kringles
    Hisham Radwan Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890 0065, Japan
    Biochim Biophys Acta 1760:347-55. 2006
  7. ncbi Processing of lysozyme at distinct loops by pepsin: a novel action for generating multiple antimicrobial peptide motifs in the newborn stomach
    Hisham R Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, 1 21 24 Korimoto, Kagoshima University, Kagoshima 890 0065, Japan
    Biochim Biophys Acta 1726:102-14. 2005
  8. ncbi Ovotransferrin antimicrobial peptide (OTAP-92) kills bacteria through a membrane damage mechanism
    H R Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, 1 21 24 Korimoto, 890 0065, Kagoshima, Japan
    Biochim Biophys Acta 1523:196-205. 2000
  9. ncbi A helix-loop-helix peptide at the upper lip of the active site cleft of lysozyme confers potent antimicrobial activity with membrane permeabilization action
    H R Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890 0065, Japan
    J Biol Chem 276:43767-74. 2001
  10. ncbi Genetic evidence that antibacterial activity of lysozyme is independent of its catalytic function
    H R Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, 1 21 24 Korimoto, Kagoshima, 890 0065, Japan
    FEBS Lett 506:27-32. 2001

Collaborators

  • T Aoki
  • Takeshi Shimogiri
  • Naotoshi Matsudomi
  • Antonio Pellegrini
  • Can-Peng Li
  • Md Imranul Hoq
  • Yasushi Sugimoto
  • Si Lhyam Myint
  • Hirofumi Enomoto
  • Arvin S Salvador
  • Tomoki Nakano
  • Shin Okamoto
  • Keiji Kinoshita
  • Kotaro Kawabe
  • Tomomi Tanoue
  • Yoshizane Maeda
  • Tomohiro Tsusaki
  • Koji Mitsuno
  • Yoshio Tsujino
  • Can Peng Li
  • Hideo Ohtomo
  • Shinichi Ohki
  • Kentaro Morizane
  • Yoko Hayashi
  • Junichi Kurawaki
  • Hiroshi Shinohara
  • Hajime Hatta
  • Jiro Tamochi
  • Hiroshi Kawakami
  • Seiichiro Aoe
  • Yasuhiro Toba

Detail Information

Publications19

  1. ncbi New drug-targeting strategy from beneath the shell of egg
    Hisham R Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890 0065, Japan
    Expert Opin Drug Deliv 7:1145-58. 2010
    ..To face this emerging global crisis, there is a need to find a new class of antibiotics that act on new microbial targets and/or harness existing antibiotics by developing new drug-targeting strategies...
  2. ncbi Identification of a distinct antibacterial domain within the N-lobe of ovotransferrin
    H R Ibrahim
    Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, Japan
    Biochim Biophys Acta 1401:289-303. 1998
    ..The peptide lost antibacterial activity when its disulfide bonds were reduced, indicating the importance of its tertiary structure for the exertion of antibiotic activity...
  3. ncbi Human lysozyme possesses novel antimicrobial peptides within its N-terminal domain that target bacterial respiration
    Hisham R Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890 0065, Japan
    J Agric Food Chem 59:10336-45. 2011
    ....
  4. ncbi Novel anticancer activity of the autocleaved ovotransferrin against human colon and breast cancer cells
    Hisham R Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima, Japan
    J Agric Food Chem 57:11383-90. 2009
    ....
  5. ncbi Ovotransferrin possesses SOD-like superoxide anion scavenging activity that is promoted by copper and manganese binding
    Hisham R Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890 0065, Japan
    Int J Biol Macromol 41:631-40. 2007
    ..This finding is the first to describe that OTf is an O(2)(-) scavenging molecule, providing insight into its novel SOD-like biological function, and heralding a fascinating opportunity for its potential candidacy as antioxidant drug...
  6. ncbi Ovotransferrin is a redox-dependent autoprocessing protein incorporating four consensus self-cleaving motifs flanking the two kringles
    Hisham Radwan Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890 0065, Japan
    Biochim Biophys Acta 1760:347-55. 2006
    ....
  7. ncbi Processing of lysozyme at distinct loops by pepsin: a novel action for generating multiple antimicrobial peptide motifs in the newborn stomach
    Hisham R Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, 1 21 24 Korimoto, Kagoshima University, Kagoshima 890 0065, Japan
    Biochim Biophys Acta 1726:102-14. 2005
    ..Finally, this finding offers a new strategy for the design of antibiotic peptide drugs with potential use in the treatment of infectious diseases...
  8. ncbi Ovotransferrin antimicrobial peptide (OTAP-92) kills bacteria through a membrane damage mechanism
    H R Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, 1 21 24 Korimoto, 890 0065, Kagoshima, Japan
    Biochim Biophys Acta 1523:196-205. 2000
    ..Further, this cationic antimicrobial peptide is capable of killing Gram-negative bacteria by crossing the OM by a self-promoted uptake and cause damage to the biological function of cytoplasmic membrane...
  9. ncbi A helix-loop-helix peptide at the upper lip of the active site cleft of lysozyme confers potent antimicrobial activity with membrane permeabilization action
    H R Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890 0065, Japan
    J Biol Chem 276:43767-74. 2001
    ....
  10. ncbi Genetic evidence that antibacterial activity of lysozyme is independent of its catalytic function
    H R Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, 1 21 24 Korimoto, Kagoshima, 890 0065, Japan
    FEBS Lett 506:27-32. 2001
    ....
  11. ncbi Strategies for new antimicrobial proteins and peptides: lysozyme and aprotinin as model molecules
    Hisham R Ibrahim
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890 0065, Japan
    Curr Pharm Des 8:671-93. 2002
    ..These approaches introduced, for the first time, a new conceptual utilization of lysozyme and aprotinin, and thus heralded a great opportunity for potential use in drug systems as new antimicrobial agent...
  12. ncbi Improvement of functional properties of egg white protein through phosphorylation by dry-heating in the presence of pyrophosphate
    Can-Peng Li
    United Chair of Applied Resource Chemistry, Course of Bioresource Science for Processing, United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima 890-0065, Japan
    J Agric Food Chem 52:5752-8. 2004
    ..These results suggest that phosphorylation by dry-heating in the presence of pyrophosphate is a useful method for improving the functional properties of EWP...
  13. ncbi Glycation and phosphorylation of beta-lactoglobulin by dry-heating: effect on protein structure and some properties
    Hirofumi Enomoto
    United Chair of Applied Resource Chemistry, Course of Bioresource Science for Processing, United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima 890 0065, Japan
    J Agric Food Chem 55:2392-8. 2007
    ..The calcium phosphate solubilizing ability of beta-Lg was enhanced by phosphorylation following glycation...
  14. ncbi Triclosan-lysozyme complex as novel antimicrobial macromolecule: a new potential of lysozyme as phenolic drug-targeting molecule
    Md Imranul Hoq
    Department of Biochemistry and Biotechnology, The United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima 890 0065, Japan
    Int J Biol Macromol 42:468-77. 2008
    ....
  15. ncbi Phosphorylation of egg white proteins by dry-heating in the presence of phosphate
    Can-Peng Li
    United Graduate School of Agricultural Sciences, and Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan
    J Agric Food Chem 51:6808-15. 2003
    ..Heat stability of EWP was improved, and calcium phosphate-solubilizing ability of EWP was enhanced by phosphorylation...
  16. ncbi Phosphorylation of ovalbumin by dry-heating in the presence of pyrophosphate: effect on protein structure and some properties
    Can-Peng Li
    United Chair of Applied Resource Chemistry, Course of Bioresource Science for Processing, United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima 890-0065, Japan
    J Agric Food Chem 53:4962-7. 2005
    ..1 degrees C by phosphorylation, the stability of OVA against heat-induced insolubility at pH 7.0 was improved. The results indicated molten (partially unfolded) conformations of OVA formed by dry-heating in the presence of pyrophosphate...
  17. ncbi Potent antimicrobial action of triclosan-lysozyme complex against skin pathogens mediated through drug-targeted delivery mechanism
    Md Imranul Hoq
    Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima, Japan
    Eur J Pharm Sci 42:130-7. 2011
    ....
  18. ncbi Phosphorylation of starch and dextrin by dry-heating in the presence of phosphate, and their calcium phosphate-solubilizing ability
    Tomoki Nakano
    Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan
    Nahrung 47:274-8. 2003
    ..The possibility of substituting of phosphorylated starch and dextrin for CPP as a calcium phosphate-absorption enhancing material is discussed herein...
  19. ncbi Effect of polymorphism in egg white lysozyme on muramidase and antibacterial activities as well as hatchability in the Japanese quail (Coturnix japonica)
    Si Lhyam Myint
    United Graduate School of Agriculture, Kagoshima University, Kagoshima, Japan
    J Anim Sci 90:1747-55. 2012
    ..These results demonstrate, for the first time, a significant difference in antibacterial activity and hatchability between 2 lysozyme phenotypes in Japanese quail...