Research Topics
Genomes and Genes | Michiyo HigashiSummaryAffiliation: Kagoshima University Country: Japan Publications
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Detail Information
Publications
Immunohistochemical study of mucin expression in periampullary adenomyomaMichiyo Higashi
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8544, Japan
J Hepatobiliary Pancreat Sci 17:275-83. 2010....- Pathobiological implications of MUC16/CA125 expression in intrahepatic cholangiocarcinoma-mass forming typeMichiyo Higashi
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Pathobiology 79:101-6. 2012..We evaluated the expression of MUC16 in intrahepatic cholangiocarcinoma-mass forming type (ICC-MF) tissues... 
The application of methylation specific electrophoresis (MSE) to DNA methylation analysis of the 5' CpG island of mucin in cancer cellsSeiya Yokoyama
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
BMC Cancer 12:67. 2012..However, conventional analytical methods for DNA methylation require a large amount of DNA and have low sensitivity...- MUC1 expression is regulated by DNA methylation and histone H3 lysine 9 modification in cancer cellsNorishige Yamada
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
Cancer Res 68:2708-16. 2008..An understanding of the epigenetic changes of MUC1 may be of importance for diagnosis of carcinogenic risk and prediction of outcome for cancer patients... - MUC4 and MUC1 expression in adenocarcinoma of the stomach correlates with vessel invasion and lymph node metastasis: an immunohistochemical study of early gastric cancerYukihiro Tamura
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
PLoS ONE 7:e49251. 2012..357, P = 0.032) and venous invasion (r = 0.377, P = 0.024). In conclusion, the expression of MUC4 as well as MUC1 in early gastric cancers is a useful marker to predict poor prognostic factors related with vessel invasion... - Promoter hypomethylation contributes to the expression of MUC3A in cancer cellsSho Kitamoto
Department of Human Pathology, Field of Oncology, Kagoshima University, Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
Biochem Biophys Res Commun 397:333-9. 2010..An understanding of epigenetic changes in MUC3A may contribute to the diagnosis of carcinogenic risk and to prediction of outcome in patients with cancer... 
MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancerNorishige Yamada
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Int J Cancer 119:1850-7. 2006..An understanding of these intimately correlated epigenetic changes may be of importance for predicting the outcome of patients with pancreatic neoplasms...- Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cellsNorishige Yamada
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8544, Japan
J Hepatobiliary Pancreat Sci 17:844-54. 2010..In this study, we show that the DNA methylation pattern is intimately correlated with MUC5AC expression in ten cancer cell lines (breast, lung, pancreas, and colon)... - MUC4 is a novel prognostic factor of extrahepatic bile duct carcinomaShugo Tamada
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Clin Cancer Res 12:4257-64. 2006..We have reported that MUC4 is a novel prognostic factor of pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma. The aim of this study is to evaluate the prognostic significance of MUC4 expression in EHBDC... - Significance of mucin expression in pancreatobiliary neoplasmsSuguru Yonezawa
Department of Human Pathology, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
J Hepatobiliary Pancreat Sci 17:108-24. 2010..Translational research of mucin gene expression mechanisms, including epigenetics, in pancreatobiliary neoplasms may give us new tools for the early and accurate detection of these neoplasms... - Mucins in human neoplasms: clinical pathology, gene expression and diagnostic applicationSuguru Yonezawa
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Pathol Int 61:697-716. 2011..Based on all of the above findings, we suggest that translational research into mucin gene expression mechanisms, including epigenetics, may provide new tools for early and accurate detection of human neoplasms... - DNA methylation and histone H3-K9 modifications contribute to MUC17 expressionSho Kitamoto
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Glycobiology 21:247-56. 2011..These understandings of the epigenetic changes of MUC17 may be of importance for the diagnosis of carcinogenic risk and the prediction of outcomes for cancer patients... - Expression of MUC17 is regulated by HIF1α-mediated hypoxic responses and requires a methylation-free hypoxia responsible element in pancreatic cancerSho Kitamoto
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
PLoS ONE 7:e44108. 2012..Taken together, these findings suggested that the HIF1α-mediated hypoxic signal pathway contributes to MUC17 expression, and DNA methylation of HRE could be a determinant of the hypoxic inducibility of MUC17 in pancreatic cancer cells... - A novel anti-MUC1 antibody against the MUC1 cytoplasmic tail domain: use in sensitive identification of poorly differentiated cells in adenocarcinoma of the stomachSuguru Yonezawa
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
Gastric Cancer 15:370-81. 2012..These cells are often scattered in granulation tissue or desmoplastic fibrotic tissue and tend to be overlooked in routine pathological examination. We aimed to raise a novel antibody that can identify the isolated cancer cells easily... - Expression of mucin antigens (MUC1 and MUC16) as a prognostic factor for mucinous adenocarcinoma of the uterine cervixShinichi Togami
Department of Obstetrics and Gynecology, Faculty of Medicine, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
J Obstet Gynaecol Res 36:588-97. 2010..Only limited data are available regarding mucin antigen expression in adenocarcinoma of the uterine cervix... - Mucin expression profile in pancreatic cancer and the precursor lesionsKohji Nagata
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
J Hepatobiliary Pancreat Surg 14:243-54. 2007..In PanINs, expression of both MUC5AC and MUC6 are an early event, whereas up-regulation of MUC1 is a late event. MCNs do not look as if they will show a specific mucin expression profile according to the literature review... - Uterine cervical carcinomas associated with lobular endocervical glandular hyperplasiaTakahiro Tsuji
Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
Histopathology 59:55-62. 2011..To investigate the clinicopathological features of cervical uterine carcinoma associated with lobular endocervical glandular hyperplasia (LEGH)... - A case of complete hydatidiform mole in a perimenopausal woman with diagnostic usefulness of p57(kip2) immunohistochemistry and HER2 fluorescent in situ hybridizationKazuhito Hatanaka
Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Pathol Res Pract 208:118-20. 2012.... - Expression profiles of MUC1, MUC2, and MUC4 mucins in human neoplasms and their relationship with biological behaviorSuguru Yonezawa
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Proteomics 8:3329-41. 2008..Further studies of the epigenetics also in MUC1 and MUC4 gene expression may be needed to understand the relationship between the expression of mucins in human neoplasms with their biological behavior... - MUC4 is a novel prognostic factor of intrahepatic cholangiocarcinoma-mass forming typeHiroaki Shibahara
Division of Human Pathology, Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Hepatology 39:220-9. 2004..In conclusion, the results suggest that expression of MUC4 in ICC-MF is a new independent factor for poor prognosis and is a useful marker to predict the outcome of the patients with ICC-MF... - Human papillomavirus in upper digestive tract tumors from three countriesAndres Castillo
Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890 8544, Japan
World J Gastroenterol 17:5295-304. 2011..To clarify human papillomavirus (HPV) involvement in carcinogenesis of the upper digestive tract of virological and pathological analyses... - Human papillomavirus is frequently detected in gefitinib-responsive lung adenocarcinomasMichihiro Baba
Department of Surgical Oncology and Digestive Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
Oncol Rep 23:1085-92. 2010..However, its low viral load makes it difficult to determine the etiological significance of these findings... - Mapping of the methylation pattern of the MUC2 promoter in pancreatic cancer cell lines, using bisulfite genomic sequencingTomofumi Hamada
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan
Cancer Lett 227:175-84. 2005..Our mapping data provide an essential basis for further studies of methylation-regulated MUC2 inactivation... - Precursor lesions of pancreatic cancerSuguru Yonezawa
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
Gut Liver 2:137-54. 2008.... - Bilobular calcifying fibrous pseudotumor in soleus muscle: a case reportNaohiro Shinohara
Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
J Med Case Reports 5:487. 2011..abstract:.. - Clinical significance of primary lesion FDG uptake for choice between oesophagectomy and endoscopic submucosal dissection for resectable oesophageal squamous cell carcinomasMasatoyo Nakajo
Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
Eur Radiol 21:2396-407. 2011..To correlate primary oesophageal squamous cell carcinoma (SCC) (18)F-fluoro-deoxyglucose (FDG) uptake with pathological factors and examine its significance regarding choice of therapy... - Mycolactone is responsible for the painlessness of Mycobacterium ulcerans infection (buruli ulcer) in a murine studyJunichiro En
Department of Human Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
Infect Immun 76:2002-7. 2008..Furthermore, mice injected with 200 microg of mycolactone showed pulmonary hemorrhage. This is the first study to demonstrate the systemic effects of mycolactone... - Epithelial-myoepithelial carcinoma of the parotid gland: correlation of dynamic magnetic resonance imaging, (18)F-fluorodeoxyglucose-positron emission tomography, and pathological findingsKoji Takumi
Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
Jpn J Radiol 28:618-22. 2010..When a parotid gland tumor shows gradual MRI contrast enhancement and focally intense FDG uptake, EMC should be included in the differential diagnosis... - Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literatureTakako Yoshioka
Department of Tumor Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Pathol Int 60:326-9. 2010..Although necrotizing sialometaplasia is relatively rare in the parotid gland, angiocentric T-cell lymphoma should be considered for a causative condition of necrotizing sialometaplasia...