Michiyo Higashi

Summary

Affiliation: Kagoshima University
Country: Japan

Publications

  1. pmc MUC4 and MUC1 expression in adenocarcinoma of the stomach correlates with vessel invasion and lymph node metastasis: an immunohistochemical study of early gastric cancer
    Yukihiro Tamura
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
    PLoS ONE 7:e49251. 2012
  2. pmc Pathobiological implications of mucin (MUC) expression in the outcome of small bowel cancer
    Hiroaki Shibahara
    Department of Palliative Care, Toyota Kosei Hospital, Toyota, Japan
    PLoS ONE 9:e86111. 2014
  3. doi request reprint Pathobiological implications of MUC16/CA125 expression in intrahepatic cholangiocarcinoma-mass forming type
    Michiyo Higashi
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Pathobiology 79:101-6. 2012
  4. doi request reprint Immunohistochemical study of mucin expression in periampullary adenomyoma
    Michiyo Higashi
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8544, Japan
    J Hepatobiliary Pancreat Sci 17:275-83. 2010
  5. pmc The application of methylation specific electrophoresis (MSE) to DNA methylation analysis of the 5' CpG island of mucin in cancer cells
    Seiya Yokoyama
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    BMC Cancer 12:67. 2012
  6. doi request reprint MUC1 expression is regulated by DNA methylation and histone H3 lysine 9 modification in cancer cells
    Norishige Yamada
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
    Cancer Res 68:2708-16. 2008
  7. pmc A novel anti-MUC1 antibody against the MUC1 cytoplasmic tail domain: use in sensitive identification of poorly differentiated cells in adenocarcinoma of the stomach
    Suguru Yonezawa
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Gastric Cancer 15:370-81. 2012
  8. ncbi request reprint MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma
    Shugo Tamada
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Clin Cancer Res 12:4257-64. 2006
  9. doi request reprint Promoter hypomethylation contributes to the expression of MUC3A in cancer cells
    Sho Kitamoto
    Department of Human Pathology, Field of Oncology, Kagoshima University, Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Biochem Biophys Res Commun 397:333-9. 2010
  10. ncbi request reprint MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer
    Norishige Yamada
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Int J Cancer 119:1850-7. 2006

Collaborators

Detail Information

Publications36

  1. pmc MUC4 and MUC1 expression in adenocarcinoma of the stomach correlates with vessel invasion and lymph node metastasis: an immunohistochemical study of early gastric cancer
    Yukihiro Tamura
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
    PLoS ONE 7:e49251. 2012
    ..357, P = 0.032) and venous invasion (r = 0.377, P = 0.024). In conclusion, the expression of MUC4 as well as MUC1 in early gastric cancers is a useful marker to predict poor prognostic factors related with vessel invasion...
  2. pmc Pathobiological implications of mucin (MUC) expression in the outcome of small bowel cancer
    Hiroaki Shibahara
    Department of Palliative Care, Toyota Kosei Hospital, Toyota, Japan
    PLoS ONE 9:e86111. 2014
    ..6, 95% confidence interval: 1.8-17). In conclusion, the study shows that a MUC5AC-positive and/or MUC16-positive status is useful as a predictor of a poor outcome in patients with SBC. ..
  3. doi request reprint Pathobiological implications of MUC16/CA125 expression in intrahepatic cholangiocarcinoma-mass forming type
    Michiyo Higashi
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Pathobiology 79:101-6. 2012
    ..We evaluated the expression of MUC16 in intrahepatic cholangiocarcinoma-mass forming type (ICC-MF) tissues...
  4. doi request reprint Immunohistochemical study of mucin expression in periampullary adenomyoma
    Michiyo Higashi
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8544, Japan
    J Hepatobiliary Pancreat Sci 17:275-83. 2010
    ....
  5. pmc The application of methylation specific electrophoresis (MSE) to DNA methylation analysis of the 5' CpG island of mucin in cancer cells
    Seiya Yokoyama
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    BMC Cancer 12:67. 2012
    ..However, conventional analytical methods for DNA methylation require a large amount of DNA and have low sensitivity...
  6. doi request reprint MUC1 expression is regulated by DNA methylation and histone H3 lysine 9 modification in cancer cells
    Norishige Yamada
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
    Cancer Res 68:2708-16. 2008
    ..An understanding of the epigenetic changes of MUC1 may be of importance for diagnosis of carcinogenic risk and prediction of outcome for cancer patients...
  7. pmc A novel anti-MUC1 antibody against the MUC1 cytoplasmic tail domain: use in sensitive identification of poorly differentiated cells in adenocarcinoma of the stomach
    Suguru Yonezawa
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Gastric Cancer 15:370-81. 2012
    ..These cells are often scattered in granulation tissue or desmoplastic fibrotic tissue and tend to be overlooked in routine pathological examination. We aimed to raise a novel antibody that can identify the isolated cancer cells easily...
  8. ncbi request reprint MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma
    Shugo Tamada
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Clin Cancer Res 12:4257-64. 2006
    ..We have reported that MUC4 is a novel prognostic factor of pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma. The aim of this study is to evaluate the prognostic significance of MUC4 expression in EHBDC...
  9. doi request reprint Promoter hypomethylation contributes to the expression of MUC3A in cancer cells
    Sho Kitamoto
    Department of Human Pathology, Field of Oncology, Kagoshima University, Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Biochem Biophys Res Commun 397:333-9. 2010
    ..An understanding of epigenetic changes in MUC3A may contribute to the diagnosis of carcinogenic risk and to prediction of outcome in patients with cancer...
  10. ncbi request reprint MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer
    Norishige Yamada
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Int J Cancer 119:1850-7. 2006
    ..An understanding of these intimately correlated epigenetic changes may be of importance for predicting the outcome of patients with pancreatic neoplasms...
  11. doi request reprint Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells
    Norishige Yamada
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8544, Japan
    J Hepatobiliary Pancreat Sci 17:844-54. 2010
    ..In this study, we show that the DNA methylation pattern is intimately correlated with MUC5AC expression in ten cancer cell lines (breast, lung, pancreas, and colon)...
  12. pmc Expression of MUC4 mucin is observed mainly in the intestinal type of intraductal papillary mucinous neoplasm of the pancreas
    Iwao Kitazono
    From the Department of Human Pathology, Field of Oncology, and Cardiovascular and Gastroenterological Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University Department of Pathology, and Department of Surgery, Kagoshima shi Medical Association Hospital, Kagoshima, Japan Departments of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE and National Sanatorium Hoshizuka Keiaien, Kanoya, Kagoshima, Japan
    Pancreas 42:1120-8. 2013
    ..This study aimed to examine expression profile of MUC4 in intraductal papillary mucinous neoplasm of the pancreas (IPMN)...
  13. doi request reprint Significance of mucin expression in pancreatobiliary neoplasms
    Suguru Yonezawa
    Department of Human Pathology, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    J Hepatobiliary Pancreat Sci 17:108-24. 2010
    ..Translational research of mucin gene expression mechanisms, including epigenetics, in pancreatobiliary neoplasms may give us new tools for the early and accurate detection of these neoplasms...
  14. ncbi request reprint Mucin expression profile in pancreatic cancer and the precursor lesions
    Kohji Nagata
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    J Hepatobiliary Pancreat Surg 14:243-54. 2007
    ..In PanINs, expression of both MUC5AC and MUC6 are an early event, whereas up-regulation of MUC1 is a late event. MCNs do not look as if they will show a specific mucin expression profile according to the literature review...
  15. doi request reprint Uterine cervical carcinomas associated with lobular endocervical glandular hyperplasia
    Takahiro Tsuji
    Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Histopathology 59:55-62. 2011
    ..To investigate the clinicopathological features of cervical uterine carcinoma associated with lobular endocervical glandular hyperplasia (LEGH)...
  16. pmc Expression of MUC17 is regulated by HIF1α-mediated hypoxic responses and requires a methylation-free hypoxia responsible element in pancreatic cancer
    Sho Kitamoto
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    PLoS ONE 7:e44108. 2012
    ..Taken together, these findings suggested that the HIF1α-mediated hypoxic signal pathway contributes to MUC17 expression, and DNA methylation of HRE could be a determinant of the hypoxic inducibility of MUC17 in pancreatic cancer cells...
  17. doi request reprint Mucins in human neoplasms: clinical pathology, gene expression and diagnostic application
    Suguru Yonezawa
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Pathol Int 61:697-716. 2011
    ..Based on all of the above findings, we suggest that translational research into mucin gene expression mechanisms, including epigenetics, may provide new tools for early and accurate detection of human neoplasms...
  18. pmc DNA methylation and histone H3-K9 modifications contribute to MUC17 expression
    Sho Kitamoto
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Glycobiology 21:247-56. 2011
    ..These understandings of the epigenetic changes of MUC17 may be of importance for the diagnosis of carcinogenic risk and the prediction of outcomes for cancer patients...
  19. doi request reprint Expression of mucin antigens (MUC1 and MUC16) as a prognostic factor for mucinous adenocarcinoma of the uterine cervix
    Shinichi Togami
    Department of Obstetrics and Gynecology, Faculty of Medicine, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Obstet Gynaecol Res 36:588-97. 2010
    ..Only limited data are available regarding mucin antigen expression in adenocarcinoma of the uterine cervix...
  20. ncbi request reprint Intrahepatic bile duct adenoma mimicking hepatic metastasis: case report and review of the literature
    Koji Takumi
    Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Magn Reson Med Sci 12:141-5. 2013
    ..Knowledge of the imaging findings of this rare entity may aid correct diagnosis. ..
  21. ncbi request reprint MUC4 is a novel prognostic factor of intrahepatic cholangiocarcinoma-mass forming type
    Hiroaki Shibahara
    Division of Human Pathology, Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Hepatology 39:220-9. 2004
    ..In conclusion, the results suggest that expression of MUC4 in ICC-MF is a new independent factor for poor prognosis and is a useful marker to predict the outcome of the patients with ICC-MF...
  22. doi request reprint A case of complete hydatidiform mole in a perimenopausal woman with diagnostic usefulness of p57(kip2) immunohistochemistry and HER2 fluorescent in situ hybridization
    Kazuhito Hatanaka
    Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Pathol Res Pract 208:118-20. 2012
    ....
  23. ncbi request reprint Expression profiles of MUC1, MUC2, and MUC4 mucins in human neoplasms and their relationship with biological behavior
    Suguru Yonezawa
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Proteomics 8:3329-41. 2008
    ..Further studies of the epigenetics also in MUC1 and MUC4 gene expression may be needed to understand the relationship between the expression of mucins in human neoplasms with their biological behavior...
  24. ncbi request reprint A rare case of internal jugular vein aneurysm with massive hemorrhage in neurofibromatosis type 1
    Tsubasa Hiraki
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Cardiovasc Pathol 23:244-7. 2014
    ..Pathological examination confirmed aneurismal wall infiltration of the neurofibromatosis. Physicians should be aware that hemorrhagic complication in NF1 can occur and be fatal. ..
  25. pmc Human papillomavirus in upper digestive tract tumors from three countries
    Andres Castillo
    Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890 8544, Japan
    World J Gastroenterol 17:5295-304. 2011
    ..To clarify human papillomavirus (HPV) involvement in carcinogenesis of the upper digestive tract of virological and pathological analyses...
  26. pmc Diagnosis of pancreatic neoplasms using a novel method of DNA methylation analysis of mucin expression in pancreatic juice
    Seiya Yokoyama
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Kagoshima, Japan
    PLoS ONE 9:e93760. 2014
    ..In conclusion, MSE analysis of human pancreatic juice may provide useful information for selection of treatment for pancreatic neoplasms. ..
  27. ncbi request reprint Human papillomavirus is frequently detected in gefitinib-responsive lung adenocarcinomas
    Michihiro Baba
    Department of Surgical Oncology and Digestive Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Oncol Rep 23:1085-92. 2010
    ..However, its low viral load makes it difficult to determine the etiological significance of these findings...
  28. pmc Precursor lesions of pancreatic cancer
    Suguru Yonezawa
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
    Gut Liver 2:137-54. 2008
    ....
  29. ncbi request reprint Mapping of the methylation pattern of the MUC2 promoter in pancreatic cancer cell lines, using bisulfite genomic sequencing
    Tomofumi Hamada
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Cancer Lett 227:175-84. 2005
    ..Our mapping data provide an essential basis for further studies of methylation-regulated MUC2 inactivation...
  30. ncbi request reprint Contrast-enhanced CT and diffusion-weighted MR imaging: performance as a prognostic factor in patients with pancreatic ductal adenocarcinoma
    Yoshihiko Fukukura
    Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima City 890 8544, Japan Electronic address
    Eur J Radiol 83:612-9. 2014
    ..To determine whether contrast enhancement of CT and apparent diffusion coefficient on diffusion-weighted MR imaging are important parameters that can predict outcomes for patients with pancreatic ductal adenocarcinoma...
  31. pmc Mycolactone is responsible for the painlessness of Mycobacterium ulcerans infection (buruli ulcer) in a murine study
    Junichiro En
    Department of Human Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Infect Immun 76:2002-7. 2008
    ..Furthermore, mice injected with 200 microg of mycolactone showed pulmonary hemorrhage. This is the first study to demonstrate the systemic effects of mycolactone...
  32. doi request reprint Clinical significance of primary lesion FDG uptake for choice between oesophagectomy and endoscopic submucosal dissection for resectable oesophageal squamous cell carcinomas
    Masatoyo Nakajo
    Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Eur Radiol 21:2396-407. 2011
    ..To correlate primary oesophageal squamous cell carcinoma (SCC) (18)F-fluoro-deoxyglucose (FDG) uptake with pathological factors and examine its significance regarding choice of therapy...
  33. pmc Bilobular calcifying fibrous pseudotumor in soleus muscle: a case report
    Naohiro Shinohara
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Med Case Reports 5:487. 2011
    ..abstract:..
  34. ncbi request reprint Carcinosarcoma of the extrahepatic bile duct
    Jun Kadono
    Second Department of Surgery, Faculty of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    J Hepatobiliary Pancreat Surg 12:328-31. 2005
    ..The patient died of a local recurrence 2 years after the surgery. Polypoid growth and ossification in the tumor could be representative features of carcinosarcoma of the extrahepatic bile duct...
  35. doi request reprint Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature
    Takako Yoshioka
    Department of Tumor Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Pathol Int 60:326-9. 2010
    ..Although necrotizing sialometaplasia is relatively rare in the parotid gland, angiocentric T-cell lymphoma should be considered for a causative condition of necrotizing sialometaplasia...
  36. doi request reprint Epithelial-myoepithelial carcinoma of the parotid gland: correlation of dynamic magnetic resonance imaging, (18)F-fluorodeoxyglucose-positron emission tomography, and pathological findings
    Koji Takumi
    Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
    Jpn J Radiol 28:618-22. 2010
    ..When a parotid gland tumor shows gradual MRI contrast enhancement and focally intense FDG uptake, EMC should be included in the differential diagnosis...