Misako Haraguchi

Summary

Affiliation: Kagoshima University
Country: Japan

Publications

  1. doi request reprint Snail modulates cell metabolism in MDCK cells
    Misako Haraguchi
    Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8544, Japan
    Biochem Biophys Res Commun 432:618-25. 2013
  2. pmc The role of the transcriptional regulator snail in cell detachment, reattachment and migration
    Misako Haraguchi
    Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan
    Cell Adh Migr 3:259-63. 2009
  3. pmc Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteins
    Misako Haraguchi
    Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    J Biol Chem 283:23514-23. 2008
  4. ncbi request reprint [Alpha catenin and cadherin]
    Misako Haraguchi
    Tanpakushitsu Kakusan Koso 51:636-41. 2006
  5. ncbi request reprint Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells
    Motoi Mukai
    Department of Cancer Chemotherapy, Institute for Cancer Research, Kagoshima University, Kagoshima 890 8520, Japan
    Cancer Sci 94:557-63. 2003
  6. doi request reprint Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-fluorouracil
    Hong ye Zhao
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan
    Cancer Res 68:7035-41. 2008
  7. ncbi request reprint Direct activation of the human major vault protein gene by DNA-damaging agents
    Yuichi Shimamoto
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Oncol Rep 15:645-52. 2006
  8. ncbi request reprint Thymidine phosphorylase inhibits apoptosis induced by cisplatin
    Ryuji Ikeda
    Department of Cancer Chemotherapy, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890, Japan
    Biochem Biophys Res Commun 301:358-63. 2003
  9. ncbi request reprint Protection against DNA damage-induced apoptosis by the angiogenic factor thymidine phosphorylase
    Hei Cheul Jeung
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8520, Japan
    FEBS Lett 580:1294-302. 2006
  10. ncbi request reprint 2-Deoxy-D-ribose inhibits hypoxia-induced apoptosis by suppressing the phosphorylation of p38 MAPK
    Ryuji Ikeda
    Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Biochem Biophys Res Commun 342:280-5. 2006

Collaborators

Detail Information

Publications36

  1. doi request reprint Snail modulates cell metabolism in MDCK cells
    Misako Haraguchi
    Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8544, Japan
    Biochem Biophys Res Commun 432:618-25. 2013
    ..On the other hand, the reduced requirements for oxygen and nutrients from the surrounding environment, might confer the resistance to cell death induced by hypoxia and malnutrition...
  2. pmc The role of the transcriptional regulator snail in cell detachment, reattachment and migration
    Misako Haraguchi
    Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan
    Cell Adh Migr 3:259-63. 2009
    ..Although very little is known about the molecular mechanisms governing metastatic dissemination, we review the possible roles of snail expression in this process. We also review the regulation of snail expression...
  3. pmc Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteins
    Misako Haraguchi
    Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    J Biol Chem 283:23514-23. 2008
    ..These results suggest that snail enhances cell detachment by multiple mechanism and leads to cell migration and reattachment at a second site, at least in part, by changing the expression of integrins in the cells...
  4. ncbi request reprint [Alpha catenin and cadherin]
    Misako Haraguchi
    Tanpakushitsu Kakusan Koso 51:636-41. 2006
  5. ncbi request reprint Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells
    Motoi Mukai
    Department of Cancer Chemotherapy, Institute for Cancer Research, Kagoshima University, Kagoshima 890 8520, Japan
    Cancer Sci 94:557-63. 2003
    ..Furthermore, STI571 itself was a potent reversing agent for MDR in P-gp-expressing KB-G2 cells...
  6. doi request reprint Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-fluorouracil
    Hong ye Zhao
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan
    Cancer Res 68:7035-41. 2008
    ..These findings suggest that the p38 MAPK pathway plays a crucial role in the induction of Egr-1 by 5-FU and that induced Egr-1 augments TSP-1 promoter activity, with the subsequent production of TSP-1 mRNA and protein...
  7. ncbi request reprint Direct activation of the human major vault protein gene by DNA-damaging agents
    Yuichi Shimamoto
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Oncol Rep 15:645-52. 2006
    ..Since the MVP protein and mRNA have low turnover rates, a slight enhancement of MVP promoter activity could lead to a considerable increase in the level of MVP...
  8. ncbi request reprint Thymidine phosphorylase inhibits apoptosis induced by cisplatin
    Ryuji Ikeda
    Department of Cancer Chemotherapy, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890, Japan
    Biochem Biophys Res Commun 301:358-63. 2003
    ..Moreover, mutant TP that has no enzymatic activity also suppressed cisplatin-induced apoptosis. These findings indicate that TP has cytoprotective functions against cytotoxic agents which are independent of its enzymatic activity...
  9. ncbi request reprint Protection against DNA damage-induced apoptosis by the angiogenic factor thymidine phosphorylase
    Hei Cheul Jeung
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8520, Japan
    FEBS Lett 580:1294-302. 2006
    ..These findings indicate that TP expression in increased by various stress including DNA damage and that TP molecules confer resistance to DNA damage-induced apoptosis in cancer cells...
  10. ncbi request reprint 2-Deoxy-D-ribose inhibits hypoxia-induced apoptosis by suppressing the phosphorylation of p38 MAPK
    Ryuji Ikeda
    Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Biochem Biophys Res Commun 342:280-5. 2006
    ..The expression levels of TP are elevated in many malignant solid tumors and thus the 2-deoxy-d-ribose generated by TP in these tumors may play an important role in tumor progression by preventing hypoxia-induced apoptosis...
  11. ncbi request reprint Binding site(s) on P-glycoprotein for a newly synthesized photoaffinity analog of agosterol A
    Masahiko Mitsuo
    Department of Cancer Chemotherapy, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Oncol Res 14:39-48. 2003
    ....
  12. pmc Localization of the GSH-dependent photolabelling site of an agosterol A analog on human MRP1
    Xiao Qin Ren
    Department of Cancer Chemotherapy, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Br J Pharmacol 138:1553-61. 2003
    ..Arg(1202) itself or the region nearby Arg(1202) may be involved in azido AG-A photolabelling...
  13. ncbi request reprint Function of the ABC signature sequences in the human multidrug resistance protein 1
    Xiao Qin Ren
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Mol Pharmacol 65:1536-42. 2004
    ..Our findings suggest that both signature sequences of MRP1 are involved in ATP hydrolysis and must be intact for the ATP hydrolysis and the transport by MRP1...
  14. ncbi request reprint Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines
    Xiao Fang Che
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima 890 8520, Japan
    Blood 107:4880-7. 2006
    ..Sodium arsenite was shown to down-regulate the expression of survivin through the NF-kappaB pathway, thus inhibiting cell growth and promoting apoptosis of ATL cells...
  15. ncbi request reprint GSH inhibits trypsinization of the C-terminal half of human MRP1
    Xiao Qin Ren
    Department of Molecular Oncology, Field of Oncology, Course of Advanced Therapeutics, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    J Biol Chem 280:6231-7. 2005
    ..These findings, together with previous reports, suggest that GSH induces a conformational change at a site within the MRP1 that is indispensable for the interaction of MRP1 with its substrates...
  16. ncbi request reprint Reversal of P-glycoprotein mediated multidrug resistance by a newly synthesized 1,4-benzothiazipine derivative, JTV-519
    Xiao Fang Che
    Department of Cancer Chemotherapy, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Cancer Lett 187:111-9. 2002
    ....
  17. ncbi request reprint MRP1 mutated in the L0 region transports SN-38 but not leukotriene C4 or estradiol-17 (beta-D-glucuronate)
    Tomohiro Noguchi
    Department Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890 8544, Japan
    Biochem Pharmacol 70:1056-65. 2005
    ..These data indicated that it may be possible to predict compounds that are transported by MRP1 in a GSH-independent manner...
  18. ncbi request reprint The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression
    Shin ichi Akiyama
    Department of Molecular Oncology, Course of Advanced Therapeutics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8544
    Cancer Sci 95:851-7. 2004
    ..Inhibition of TP activity and function appears to be a promising approach for the chemotherapy of various tumors...
  19. ncbi request reprint 2-Deoxy-L-ribose inhibits the invasion of thymidine phosphorylase-overexpressing tumors by suppressing matrix metalloproteinase-9
    Yuichi Nakajima
    Department of Molecular Oncology, Field of Oncology, Course of Advanced Therapeutics, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    Int J Cancer 119:1710-6. 2006
    ..Furthermore, L-dRib suppressed the mRNA level of MMP-9 in cultured KB/TP cells, and the invasive activity of the cells. L-dRib may be useful for the suppression of invasion of TP-expressing tumor cells...
  20. doi request reprint Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cells
    Hong ye Zhao
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima, Japan
    Cancer Lett 270:156-63. 2008
    ..Meanwhile, 5-FU dose-dependently decreased the expression of miR-17-92 cluster. These findings suggest that 5-FU decreased the expression of c-Myc and consequently miR-17-92 cluster and increased the expression of TSP-1 mRNA...
  21. ncbi request reprint A positively charged amino acid proximal to the C-terminus of TM17 of MRP1 is indispensable for GSH-dependent binding of substrates and for transport of LTC4
    Xiao Qin Ren
    Department of Cancer Chemotherapy, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Biochemistry 41:14132-40. 2002
    ..Furthermore, our findings suggest that the charged amino acid Arg(1249) proximal to the C-terminus of TM helix 17 is indispensable for MRP1-substrate interaction and the function of MRP1...
  22. ncbi request reprint Thymidine phosphorylase suppresses apoptosis induced by microtubule-interfering agents
    Hei Cheul Jeung
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima, 890 8520, Japan
    Biochem Pharmacol 70:13-21. 2005
    ..In addition, we show that TP-induced inhibition of Bcl-2 phosphorylation and suppression of FasL may contribute to the protective function of TP in cancer cells...
  23. ncbi request reprint Characterization of MVP and VPARP assembly into vault ribonucleoprotein complexes
    Chun Lei Zheng
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Biochem Biophys Res Commun 326:100-7. 2005
    ..This suggests that the activity of VPARP is not essential for interaction with MVP-self-assembled vault-like particles. In conclusion, our findings provide an insight into potential mechanisms of physiological vault assembly...
  24. ncbi request reprint Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells
    Ryuji Ikeda
    Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Cancer Sci 96:372-6. 2005
    ..Cepharanthine in combination with ADM should be useful for treating patients with tumors...
  25. ncbi request reprint Suppression of thymidine phosphorylase-mediated angiogenesis and tumor growth by 2-deoxy-L-ribose
    Hiroshi Uchimiya
    Department of Cancer Chemotherapy, Institute for Cancer Research, Kagoshima University, Faculty of Medicine, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Cancer Res 62:2834-9. 2002
    ..Thus, lRib is a potentially useful agent for the suppression of TP-dependent angiogenesis and tumor growth...
  26. ncbi request reprint [Thymidine phosphorylase inhibits apoptosis induced by anticancer agents]
    Ryuji Ikeda
    Department of Clinical Pharmacy and Pharmacology, Department of Cancer Chemotherapy, Institute for Cancer Research, Graduate School of Medical and Dental Sciences, Kagoshima University 890 8520, Sakuragaoka 8 35 1, Japan
    Nihon Yakurigaku Zasshi 122:84P-86P. 2003
    ..Moreover, mutant TP that has no enzymatic activity also suppressed cisplatin-induced apoptosis. These findings indicate that TP has cytoprotective functions against cytotoxic agents which are independent of its enzymatic activity...
  27. ncbi request reprint Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5'-DFUR cytotoxicity
    Kengo Tsuneyoshi
    Department of Molecular Oncology, Field of Oncology, Course of Advanced Therapeutics, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Cancer Lett 244:239-46. 2006
    ..These results suggest that AZT enhances the cytotoxic effect of 5'-DFUR on U937 cells by upregulating TP activity in addition to its inhibition of thymidine kinase (TK) activity and reduction of intracellular dTTP pools...
  28. ncbi request reprint Enhanced nucleotide excision repair in cisplatin resistant human KB carcinoma cells
    Motoi Mukai
    Department of Cancer Chemotherapy, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    Oncol Rep 9:839-44. 2002
    ..These findings suggest that the enhanced NER activity for DNA damage caused by cisplatin may be involved in cisplatin resistance in KCP-4 cells...
  29. doi request reprint The transcription factor Snail expressed in cutaneous squamous cell carcinoma induces epithelial-mesenchymal transition and down-regulates COX-2
    Mitsuyoshi Shimokawa
    Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Biochem Biophys Res Commun 430:1078-82. 2013
    ..Consistent with these observations, reporter assays revealed that COX-2 promoter activity was repressed upon Snail overexpression. Thus Snail down-regulates COX-2 in these cells...
  30. doi request reprint The transcription factor Snail enhanced the degradation of E-cadherin and desmoglein 2 in oral squamous cell carcinoma cells
    Kenichi Kume
    Department of Biochemistry and Molecular Biology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Biochem Biophys Res Commun 430:889-94. 2013
    ..Therefore, in HSC-4 cells Snail regulates levels of these proteins both transcriptionally and post-translationally...
  31. ncbi request reprint Molecular basis for the inhibition of hypoxia-induced apoptosis by 2-deoxy-D-ribose
    Ryuji Ikeda
    Department of Cancer Chemotherapy, Institute for Cancer Research, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Biochem Biophys Res Commun 291:806-12. 2002
    ..2-Deoxy-L-ribose and its analogs may enhance apoptosis and suppress the growth of tumors by competitively inhibiting the activities of 2-deoxy-d-ribose and thus these analogs show promise for anti-tumor therapy...
  32. pmc Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice
    Misako Haraguchi
    Department of Cancer Chemotherapy, Institute for Cancer Research, Third Department of Internal Medicin, Kagoshima University, 8 35 1 Sakura gaoka, Kagoshima 890 8520, Japan
    Mol Cell Biol 22:5212-21. 2002
    ..Since lesions in the brain do not appear to be due to mitochondrial alterations and pathological changes in the muscle were not found, this model will provide further insights into the causes of MNGIE...
  33. ncbi request reprint Targeting of antigen to dendritic cells with poly(gamma-glutamic acid) nanoparticles induces antigen-specific humoral and cellular immunity
    Tomofumi Uto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    J Immunol 178:2979-86. 2007
    ..These results suggest that Ag-carrying gamma-PGA NPs are capable of inducing strong cellular and humoral immune responses and might be potentially useful as effective vaccine adjuvants for the therapy of infectious diseases...
  34. ncbi request reprint Apolipoprotein E regulates primary cultured human mesangial cell proliferation
    Yixiang Zhang
    Second Division of Internal Medicine, Medical Faculty, Kagoshima University, Kagoshima, Japan
    Nephron Exp Nephrol 102:e62-70. 2006
    ..The objective of this study was to determine how apo E acts on human kidneys using primary cultured normal human mesangial cells (NHMCs) rather than animals used in previous studies...
  35. ncbi request reprint Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-ribose
    Yuichi Nakajima
    Department of Molecular Oncology, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima Japan
    Cancer Res 64:1794-801. 2004
    ..These findings suggest that L-dRib may be useful in a clinical setting for the suppression of metastasis of tumor cells expressing TP...
  36. ncbi request reprint Molecular basis for the involvement of thymidine phosphorylase in cancer invasion
    Takenari Gotanda
    Department of Urology, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
    Int J Mol Med 17:1085-91. 2006
    ..Taken together these data indicate that TP enhances the invasion of tumor cells through the induction of invasion-related genes...