Research Topics
Genomes and Genes | Misako HaraguchiSummaryAffiliation: Kagoshima University Country: Japan Publications
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Publications
Snail modulates cell metabolism in MDCK cellsMisako Haraguchi
Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8544, Japan
Biochem Biophys Res Commun 432:618-25. 2013..On the other hand, the reduced requirements for oxygen and nutrients from the surrounding environment, might confer the resistance to cell death induced by hypoxia and malnutrition...
[Alpha catenin and cadherin]Misako Haraguchi
Tanpakushitsu Kakusan Koso 51:636-41. 2006
Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteinsMisako Haraguchi
Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
J Biol Chem 283:23514-23. 2008..These results suggest that snail enhances cell detachment by multiple mechanism and leads to cell migration and reattachment at a second site, at least in part, by changing the expression of integrins in the cells...- The role of the transcriptional regulator snail in cell detachment, reattachment and migrationMisako Haraguchi
Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan
Cell Adh Migr 3:259-63. 2009..Although very little is known about the molecular mechanisms governing metastatic dissemination, we review the possible roles of snail expression in this process. We also review the regulation of snail expression... - Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cellsMotoi Mukai
Department of Cancer Chemotherapy, Institute for Cancer Research, Kagoshima University, Kagoshima 890-8520, Japan
Cancer Sci 94:557-63. 2003..Furthermore, STI571 itself was a potent reversing agent for MDR in P-gp-expressing KB-G2 cells... - Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-fluorouracilHong ye Zhao
Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan
Cancer Res 68:7035-41. 2008..These findings suggest that the p38 MAPK pathway plays a crucial role in the induction of Egr-1 by 5-FU and that induced Egr-1 augments TSP-1 promoter activity, with the subsequent production of TSP-1 mRNA and protein... - Direct activation of the human major vault protein gene by DNA-damaging agentsYuichi Shimamoto
Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
Oncol Rep 15:645-52. 2006..Since the MVP protein and mRNA have low turnover rates, a slight enhancement of MVP promoter activity could lead to a considerable increase in the level of MVP... - Thymidine phosphorylase inhibits apoptosis induced by cisplatinRyuji Ikeda
Department of Cancer Chemotherapy, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890, Japan
Biochem Biophys Res Commun 301:358-63. 2003..Moreover, mutant TP that has no enzymatic activity also suppressed cisplatin-induced apoptosis. These findings indicate that TP has cytoprotective functions against cytotoxic agents which are independent of its enzymatic activity... - Binding site(s) on P-glycoprotein for a newly synthesized photoaffinity analog of agosterol AMasahiko Mitsuo
Department of Cancer Chemotherapy, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima 890-8520, Japan
Oncol Res 14:39-48. 2003.... - 2-Deoxy-D-ribose inhibits hypoxia-induced apoptosis by suppressing the phosphorylation of p38 MAPKRyuji Ikeda
Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
Biochem Biophys Res Commun 342:280-5. 2006..The expression levels of TP are elevated in many malignant solid tumors and thus the 2-deoxy-d-ribose generated by TP in these tumors may play an important role in tumor progression by preventing hypoxia-induced apoptosis... - Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cellsRyuji Ikeda
Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
Cancer Sci 96:372-6. 2005..Cepharanthine in combination with ADM should be useful for treating patients with tumors... - Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell linesXiao-Fang Che
Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima 890-8520, Japan
Blood 107:4880-7. 2006..Sodium arsenite was shown to down-regulate the expression of survivin through the NF-kappaB pathway, thus inhibiting cell growth and promoting apoptosis of ATL cells... - Localization of the GSH-dependent photolabelling site of an agosterol A analog on human MRP1Xiao-Qin Ren
Department of Cancer Chemotherapy, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima 890-8520, Japan
Br J Pharmacol 138:1553-61. 2003..Arg(1202) itself or the region nearby Arg(1202) may be involved in azido AG-A photolabelling... - GSH inhibits trypsinization of the C-terminal half of human MRP1Xiao-Qin Ren
Department of Molecular Oncology, Field of Oncology, Course of Advanced Therapeutics, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
J Biol Chem 280:6231-7. 2005..These findings, together with previous reports, suggest that GSH induces a conformational change at a site within the MRP1 that is indispensable for the interaction of MRP1 with its substrates... - The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progressionShin ichi Akiyama
Department of Molecular Oncology, Course of Advanced Therapeutics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8544
Cancer Sci 95:851-7. 2004..Inhibition of TP activity and function appears to be a promising approach for the chemotherapy of various tumors... - Protection against DNA damage-induced apoptosis by the angiogenic factor thymidine phosphorylaseHei Cheul Jeung
Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8520, Japan
FEBS Lett 580:1294-302. 2006..These findings indicate that TP expression in increased by various stress including DNA damage and that TP molecules confer resistance to DNA damage-induced apoptosis in cancer cells... - Function of the ABC signature sequences in the human multidrug resistance protein 1Xiao Qin Ren
Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
Mol Pharmacol 65:1536-42. 2004..Our findings suggest that both signature sequences of MRP1 are involved in ATP hydrolysis and must be intact for the ATP hydrolysis and the transport by MRP1... - Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cellsHong ye Zhao
Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima, Japan
Cancer Lett 270:156-63. 2008..Meanwhile, 5-FU dose-dependently decreased the expression of miR-17-92 cluster. These findings suggest that 5-FU decreased the expression of c-Myc and consequently miR-17-92 cluster and increased the expression of TSP-1 mRNA... - 2-Deoxy-L-ribose inhibits the invasion of thymidine phosphorylase-overexpressing tumors by suppressing matrix metalloproteinase-9Yuichi Nakajima
Department of Molecular Oncology, Field of Oncology, Course of Advanced Therapeutics, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, Japan
Int J Cancer 119:1710-6. 2006..Furthermore, L-dRib suppressed the mRNA level of MMP-9 in cultured KB/TP cells, and the invasive activity of the cells. L-dRib may be useful for the suppression of invasion of TP-expressing tumor cells... - Characterization of MVP and VPARP assembly into vault ribonucleoprotein complexesChun-Lei Zheng
Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
Biochem Biophys Res Commun 326:100-7. 2005..This suggests that the activity of VPARP is not essential for interaction with MVP-self-assembled vault-like particles. In conclusion, our findings provide an insight into potential mechanisms of physiological vault assembly... - Thymidine phosphorylase suppresses apoptosis induced by microtubule-interfering agentsHei-Cheul Jeung
Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan
Biochem Pharmacol 70:13-21. 2005..In addition, we show that TP-induced inhibition of Bcl-2 phosphorylation and suppression of FasL may contribute to the protective function of TP in cancer cells... - MRP1 mutated in the L0 region transports SN-38 but not leukotriene C4 or estradiol-17 (beta-D-glucuronate)Tomohiro Noguchi
Department Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima 890-8544, Japan
Biochem Pharmacol 70:1056-65. 2005..These data indicated that it may be possible to predict compounds that are transported by MRP1 in a GSH-independent manner... - Suppression of thymidine phosphorylase-mediated angiogenesis and tumor growth by 2-deoxy-L-riboseHiroshi Uchimiya
Department of Cancer Chemotherapy, Institute for Cancer Research, Kagoshima University, Faculty of Medicine, Sakuragaoka 8-35-1, Kagoshima 890-8520, Japan
Cancer Res 62:2834-9. 2002..Thus, lRib is a potentially useful agent for the suppression of TP-dependent angiogenesis and tumor growth... - [Thymidine phosphorylase inhibits apoptosis induced by anticancer agents]Ryuji Ikeda
Department of Clinical Pharmacy and Pharmacology, Department of Cancer Chemotherapy, Institute for Cancer Research, Graduate School of Medical and Dental Sciences, Kagoshima University 890-8520, Sakuragaoka 8-35-1, Japan
Nippon Yakurigaku Zasshi 122:84P-86P. 2003..Moreover, mutant TP that has no enzymatic activity also suppressed cisplatin-induced apoptosis. These findings indicate that TP has cytoprotective functions against cytotoxic agents which are independent of its enzymatic activity... - A positively charged amino acid proximal to the C-terminus of TM17 of MRP1 is indispensable for GSH-dependent binding of substrates and for transport of LTC4Xiao-Qin Ren
Department of Cancer Chemotherapy, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima 890-8520, Japan
Biochemistry 41:14132-40. 2002..Furthermore, our findings suggest that the charged amino acid Arg(1249) proximal to the C-terminus of TM helix 17 is indispensable for MRP1-substrate interaction and the function of MRP1... - Reversal of P-glycoprotein mediated multidrug resistance by a newly synthesized 1,4-benzothiazipine derivative, JTV-519Xiao-Fang Che
Department of Cancer Chemotherapy, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
Cancer Lett 187:111-9. 2002.... - Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5'-DFUR cytotoxicityKengo Tsuneyoshi
Department of Molecular Oncology, Field of Oncology, Course of Advanced Therapeutics, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima 890-8520, Japan
Cancer Lett 244:239-46. 2006..These results suggest that AZT enhances the cytotoxic effect of 5'-DFUR on U937 cells by upregulating TP activity in addition to its inhibition of thymidine kinase (TK) activity and reduction of intracellular dTTP pools... - Enhanced nucleotide excision repair in cisplatin resistant human KB carcinoma cellsMotoi Mukai
Department of Cancer Chemotherapy, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
Oncol Rep 9:839-44. 2002..These findings suggest that the enhanced NER activity for DNA damage caused by cisplatin may be involved in cisplatin resistance in KCP-4 cells... - The transcription factor Snail expressed in cutaneous squamous cell carcinoma induces epithelial-mesenchymal transition and down-regulates COX-2Mitsuyoshi Shimokawa
Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
Biochem Biophys Res Commun 430:1078-82. 2013..Consistent with these observations, reporter assays revealed that COX-2 promoter activity was repressed upon Snail overexpression. Thus Snail down-regulates COX-2 in these cells... - Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in miceMisako Haraguchi
Department of Cancer Chemotherapy, Institute for Cancer Research, Third Department of Internal Medicin, Kagoshima University, 8 35 1 Sakura gaoka, Kagoshima 890 8520, Japan
Mol Cell Biol 22:5212-21. 2002..Since lesions in the brain do not appear to be due to mitochondrial alterations and pathological changes in the muscle were not found, this model will provide further insights into the causes of MNGIE... - Molecular basis for the inhibition of hypoxia-induced apoptosis by 2-deoxy-D-riboseRyuji Ikeda
Department of Cancer Chemotherapy, Institute for Cancer Research, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima 890-8520, Japan
Biochem Biophys Res Commun 291:806-12. 2002..2-Deoxy-L-ribose and its analogs may enhance apoptosis and suppress the growth of tumors by competitively inhibiting the activities of 2-deoxy-d-ribose and thus these analogs show promise for anti-tumor therapy... - The transcription factor Snail enhanced the degradation of E-cadherin and desmoglein 2 in oral squamous cell carcinoma cellsKenichi Kume
Department of Biochemistry and Molecular Biology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
Biochem Biophys Res Commun 430:889-94. 2013..Therefore, in HSC-4 cells Snail regulates levels of these proteins both transcriptionally and post-translationally... - Apolipoprotein E regulates primary cultured human mesangial cell proliferationYixiang Zhang
Second Division of Internal Medicine, Medical Faculty, Kagoshima University, Kagoshima, Japan
Nephron Exp Nephrol 102:e62-70. 2006..The objective of this study was to determine how apo E acts on human kidneys using primary cultured normal human mesangial cells (NHMCs) rather than animals used in previous studies... - Targeting of antigen to dendritic cells with poly(gamma-glutamic acid) nanoparticles induces antigen-specific humoral and cellular immunityTomofumi Uto
Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
J Immunol 178:2979-86. 2007..These results suggest that Ag-carrying gamma-PGA NPs are capable of inducing strong cellular and humoral immune responses and might be potentially useful as effective vaccine adjuvants for the therapy of infectious diseases... - Molecular basis for the involvement of thymidine phosphorylase in cancer invasionTakenari Gotanda
Department of Urology, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
Int J Mol Med 17:1085-91. 2006..Taken together these data indicate that TP enhances the invasion of tumor cells through the induction of invasion-related genes... - Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-riboseYuichi Nakajima
Department of Molecular Oncology, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima Japan
Cancer Res 64:1794-801. 2004..These findings suggest that L-dRib may be useful in a clinical setting for the suppression of metastasis of tumor cells expressing TP...