M Baba

Summary

Affiliation: Kagoshima University
Country: Japan

Publications

  1. ncbi Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate
    Guangwei Yang
    Department of Pharmacology, School of Medicine, Yale University, 333 Cedar Street, New Haven, CT 06520, USA
    Antimicrob Agents Chemother 52:2035-42. 2008
  2. ncbi Anti-HIV-1 activity and structure-activity relationship of cepharanoline derivatives in chronically infected cells
    M Baba
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan
    Antivir Chem Chemother 12:307-12. 2001
  3. ncbi Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors
    Xin Wang
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    Mol Pharmacol 63:65-72. 2003
  4. ncbi Inhibitors of HIV-1 gene expression and transcription
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    Curr Top Med Chem 4:871-82. 2004
  5. ncbi [Recent progress in anti-HIM-1 research]
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    Uirusu 54:59-66. 2004
  6. ncbi TAK-652 inhibits CCR5-mediated human immunodeficiency virus type 1 infection in vitro and has favorable pharmacokinetics in humans
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    Antimicrob Agents Chemother 49:4584-91. 2005
  7. ncbi SJ-3366 Sam Jin Pharmaceutical
    Masanori Baba
    Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan
    Curr Opin Investig Drugs 3:1146-8. 2002
  8. ncbi [Advances in antiviral chemotherapy]
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan
    Uirusu 55:69-75. 2005
  9. ncbi Establishment of a CCR5-expressing T-lymphoblastoid cell line highly susceptible to R5 HIV type 1
    M Baba
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan
    AIDS Res Hum Retroviruses 16:935-41. 2000
  10. ncbi Potent and selective inhibition of human immunodeficiency virus type 1 transcription by piperazinyloxoquinoline derivatives
    M Baba
    Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Sakuragaoka, Japan
    Antimicrob Agents Chemother 41:1250-5. 1997

Collaborators

Detail Information

Publications98

  1. ncbi Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate
    Guangwei Yang
    Department of Pharmacology, School of Medicine, Yale University, 333 Cedar Street, New Haven, CT 06520, USA
    Antimicrob Agents Chemother 52:2035-42. 2008
    ..The structural basis for the higher binding affinity of 4'-Ed4TTP than of d4TTP could be the additional binding of the 4'-ethynyl group in a preformed hydrophobic pocket by A114, Y115, M184, F160, and part of D185...
  2. ncbi Anti-HIV-1 activity and structure-activity relationship of cepharanoline derivatives in chronically infected cells
    M Baba
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan
    Antivir Chem Chemother 12:307-12. 2001
    ..The 50% effective concentrations of this compound and cepharanthine were 0.0041 and 0.028 microg/ml (0.0060 and 0.046 microM), respectively...
  3. ncbi Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors
    Xin Wang
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    Mol Pharmacol 63:65-72. 2003
    ..An analysis for intracellular metabolism of AZT suggests that the resistance is attributed to the increase of ATP-dependent efflux of its metabolites, presumably AZT 5'-monophosphate, in MT-4/DOX 500 cells...
  4. ncbi Inhibitors of HIV-1 gene expression and transcription
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    Curr Top Med Chem 4:871-82. 2004
    ..In addition, various compounds have been identified as inhibitors of HIV-1 gene expression and transcription, yet their precise mechanisms are still unknown...
  5. ncbi [Recent progress in anti-HIM-1 research]
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    Uirusu 54:59-66. 2004
    ..Furthermore, clinical trials with CCR 5 (coreceptor of HIV-1) antagonists are in progress, and inhibitors of integrase, HIV-1 gene expression, and virion assembly have been identified...
  6. ncbi TAK-652 inhibits CCR5-mediated human immunodeficiency virus type 1 infection in vitro and has favorable pharmacokinetics in humans
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    Antimicrob Agents Chemother 49:4584-91. 2005
    ..The compound displayed favorable pharmacokinetics, and its plasma concentration was 7.2 ng/ml (9.1 nM) even 24 h after the administration of 25 mg. Thus, TAK-652 is a promising candidate as a novel entry inhibitor of HIV-1...
  7. ncbi SJ-3366 Sam Jin Pharmaceutical
    Masanori Baba
    Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan
    Curr Opin Investig Drugs 3:1146-8. 2002
    ..As of June 1998, Sam Jin had been awarded a patent for SJ-3366 in South Africa, with applications pending in 22 other countries [302450]...
  8. ncbi [Advances in antiviral chemotherapy]
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan
    Uirusu 55:69-75. 2005
    ..Thus, it seems still mandatory to continue the search for more effective and less toxic compounds against various viral infections...
  9. ncbi Establishment of a CCR5-expressing T-lymphoblastoid cell line highly susceptible to R5 HIV type 1
    M Baba
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan
    AIDS Res Hum Retroviruses 16:935-41. 2000
    ..These results indicate that the established cell line will be an extremely useful tool for experiments with R5 HIV-1...
  10. ncbi Potent and selective inhibition of human immunodeficiency virus type 1 transcription by piperazinyloxoquinoline derivatives
    M Baba
    Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Sakuragaoka, Japan
    Antimicrob Agents Chemother 41:1250-5. 1997
    ..It was not inhibitory to HIV-1 Tat or the cellular transcription factors NF-kappaB and Sp1, suggesting that the piperazinyloxoquinoline derivatives are a group of HIV-1 transcription inhibitors with a unique mechanism of action...
  11. ncbi Marked suppression of T cells by a benzothiophene derivative in patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis
    M Makino
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    Clin Diagn Lab Immunol 6:316-22. 1999
    ..CI-959-A showed little toxicity toward lymphoma or HTLV-I-infected T-cell lines or toward monocytes and cultured DCs. These results suggest that CI-959-A might be a potent anti-HAM/TSP agent...
  12. ncbi Three-drug combination of MKC-442, lamivudine and zidovudine in vitro: potential approach towards effective chemotherapy against HIV-1
    G Piras
    Division of Human Retroviruses, Faculty of Medicine, Kagoshima University, Japan
    AIDS 11:469-75. 1997
    ..CONCLUSIONS: Our results demonstrate a potential efficacy of MKC-442 in combination with 3TC and ZDV, and the three-drug combination should be considered for treatment of AIDS patients...
  13. ncbi Apoptosis and cell proliferation in esophageal sqamous cell carcinoma treated by chemotherapy
    H Okumura
    First Department of Surgery, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    Cancer Lett 158:211-6. 2000
    ..60, P<0.05). In esophageal carcinoma, p53-negative tumors with highly proliferative cells might be susceptible to apoptosis induced by chemotherapy...
  14. ncbi Inhibition of human immunodeficiency virus type 1 replication and cytokine production by fluoroquinoline derivatives
    M Baba
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima 890, Japan
    Mol Pharmacol 53:1097-103. 1998
    ....
  15. ncbi Inhibition of human immunodeficiency virus type 1 replication in acutely and chronically infected cells by EM2487, a novel substance produced by a Streptomyces species
    M Baba
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    Antimicrob Agents Chemother 43:2350-5. 1999
    ..These results suggest that the mechanism of action is attributable in part to the inhibition of Tat function...
  16. ncbi Induction of cellular resistance to nucleoside reverse transcriptase inhibitors by the wild-type breast cancer resistance protein
    Xin Wang
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan
    Biochem Pharmacol 68:1363-70. 2004
    ..Furthermore, the BCRP-specific inhibitor fumitremorgin C completely restored the reduction of AZT in MT-4/BCRP cells. These results indicate that, like BCRP(R482M), BCRP(WT) also plays an important role in cellular resistance to NRTIs...
  17. ncbi How the lymph node metastases toward cervico-upper mediastinal region affect the outcome of patients with carcinoma of the thoracic esophagus
    S Nakano
    First Department of Surgery, Faculty of Medicine, Kagoshima University, Japan
    Jpn J Clin Oncol 29:248-51. 1999
    ..The aim of this study was to establish whether the site of lymph node metastasis influences the survival of patients with carcinoma of the thoracic esophagus...
  18. ncbi Complete inhibition of viral breakthrough by combination of MKC-442 with AZT during a long-term culture of HIV-1 infected cells
    M Okamoto
    Division of Human Retroviruses, Faculty of Medicine, Kagoshima University 8 35 1, Japan
    Antiviral Res 31:69-77. 1996
    ....
  19. ncbi Effect of neoadjuvant chemotherapy for lymph node micrometastasis and tumor cell microinvolvement in the patients with esophageal carcinoma
    S Natsugoe
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Cancer Lett 159:119-25. 2000
    ..0%; 2/20) was significantly lower than that in the surgery group (40.0%; 8/20; P=0.032). Preoperative chemotherapy in this regime was not effective, except for some patients with TCM alone...
  20. ncbi Highly potent inhibition of human immunodeficiency virus type 1 replication by TAK-220, an orally bioavailable small-molecule CCR5 antagonist
    Katsunori Takashima
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan
    Antimicrob Agents Chemother 49:3474-82. 2005
    ..At a dose of 5 mg/kg of body weight, TAK-220 showed oral bioavailabilities of 9.5 and 28.9% in rats and monkeys, respectively. Thus, TAK-220 is a promising candidate for the treatment of HIV-1 infection...
  21. ncbi Inhibitory effects of small-molecule CCR5 antagonists on human immunodeficiency virus type 1 envelope-mediated membrane fusion and viral replication
    K Takashima
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima 890-8520, Japan
    Antimicrob Agents Chemother 45:3538-43. 2001
    ..These results indicate that the HIV-1 Env-mediated membrane fusion assay is a useful tool for the evaluation of entry inhibitors...
  22. ncbi Isolation and characterization of human immunodeficiency virus type 1 resistant to the small-molecule CCR5 antagonist TAK-652
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    Antimicrob Agents Chemother 51:707-15. 2007
    ..Several amino acid changes not only in the V3 region but also in other Env regions seemed to be required for R5 HIV-1 to acquire complete resistance to TAK-652...
  23. ncbi Three-drug combinations of emivirine and nucleoside reverse transcriptase inhibitors in vitro: long-term culture of HIV-1-infected cells and breakthrough viruses
    T Nitanda
    Division of Human Retroviruses, Centre for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    Antivir Chem Chemother 12:161-7. 2001
    ..These viruses had specific amino acid mutations in their reverse transcriptase...
  24. ncbi The role of human T-lymphotropic virus type 1 (HTLV-1)-infected dendritic cells in the development of HTLV-1-associated myelopathy/tropical spastic paraparesis
    M Makino
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    J Virol 73:4575-81. 1999
    ..These results suggest that DCs are susceptible to HTLV-1 infection and that their cognate interaction with T cells may contribute to the development of HAM/TSP...
  25. ncbi Inhibition of human T-lymphotropic virus type I gene expression by the Streptomyces-derived substance EM2487
    X Wang
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan
    Antivir Chem Chemother 13:177-83. 2002
    ..These results suggest that the inhibition occurred at the viral transcription level, but it cannot be attributed to the inhibition of the Tax function...
  26. ncbi Number of lymph node metastases determined by presurgical ultrasound and endoscopic ultrasound is related to prognosis in patients with esophageal carcinoma
    S Natsugoe
    First Department of Surgery, Kagoshima University School of Medicine, Sakuragaoka, Kagoshima, Japan
    Ann Surg 234:613-8. 2001
    ....
  27. ncbi The role of neoadjuvant radiochemotherapy using low-dose fraction cisplatin and 5-fluorouracil in patients with carcinoma of the esophagus
    S Nakano
    First Department of Surgery, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    Jpn J Thorac Cardiovasc Surg 49:11-6. 2001
    ..The combination of radiation and low-dose fraction CDDP/5-FU thus is first choice in neoadjuvant radiochemotherapy for the advanced esophageal carcinoma...
  28. ncbi Anti-human immunodeficiency virus type 1 activity and resistance profile of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine in vitro
    Takao Nitanda
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan
    Antimicrob Agents Chemother 49:3355-60. 2005
    ..Since 4'-Ed4T has increased anti-HIV-1 activity, decreased cytotoxicity, and a different resistance profile, it should be considered for further development as a new member of NRTIs...
  29. ncbi Recent status of HIV-1 gene expression inhibitors
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8544, Japan
    Antiviral Res 71:301-6. 2006
    ....
  30. ncbi Suppression of cytokine production and neural cell death by the anti-inflammatory alkaloid cepharanthine: a potential agent against HIV-1 encephalopathy
    M Okamoto
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, 8-35-1, Sakuragaoka, 890-8520, Kagoshima, Japan
    Biochem Pharmacol 62:747-53. 2001
    ..Thus, cepharanthine should be investigated further for its therapeutic and prophylactic potential in HIV-1-associated CNS disorders...
  31. ncbi Micrometastases in the cervical lymph nodes in esophageal squamous cell carcinoma
    S W Qubain
    First Department of Surgery, Kagoshima University, School of Medicine, Kagoshima, Japan
    Dis Esophagus 14:143-8. 2001
    ..Cervical lymph node metastasis, including micrometastasis, can be predicted by preoperative ultrasonography and the routine histologic examination of mediastinal recurrent nerve nodes...
  32. ncbi Potent and selective inhibition of Tat-dependent HIV-1 replication in chronically infected cells by a novel naphthalene derivative JTK-101
    Xin Wang
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Antivir Chem Chemother 18:201-11. 2007
    ..These results suggest that JTK-101 exerts its anti-HIV-1 activity through the inhibition of known or unknown Tat cofactors, presumably CDK9/cyclin T1...
  33. ncbi Bax and Bcl-X(L) expression are not related to prognosis in patients with advanced esophageal squamous cell carcinoma
    S Natsugoe
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, 890 8520, Kagoshima, Japan
    Cancer Lett 174:91-7. 2001
    ..Multiple apoptotic pathways may be associated with advanced esophageal squamous cell carcinoma...
  34. ncbi Can sentinel node navigation surgery reduce the extent of lymph node dissection in gastric cancer?
    T Aikou
    First Department of Surgery, Kagoshima University School of Medicine, Japan
    Ann Surg Oncol 8:90S-93S. 2001
    ..SNNS for gastric cancer is a promising technique; further study of various anatomic and pathologic factors will indicate whether it can be used to determine the extent of lymphadenectomy necessary in patients with early gastric cancer...
  35. ncbi Expression of p21WAF1/Cip1 in the p53-dependent pathway is related to prognosis in patients with advanced esophageal carcinoma
    S Natsugoe
    First Department of Surgery, Kagoshima University School of Medicine, Japan
    Clin Cancer Res 5:2445-9. 1999
    ..Examination of p21-positive expression in the p53-dependent pathway will help to estimate the favorable prognosis of patients with advanced esophageal carcinoma...
  36. ncbi Long-term survivors of advanced esophageal cancer without surgical treatment: a multicenter questionnaire survey in Kyushu, Japan
    S Natsugoe
    First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
    Dis Esophagus 16:239-42. 2003
    ..To improve the prognosis of patients with advanced esophageal cancer who, for various causes, cannot undergo surgical treatment, a new protocol for adjuvant therapy is required...
  37. ncbi Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells
    Katsuaki Sato
    Department of Immunology and Medical Zoology, Division of Human Retroviruses, Center for Chronic Viral Diseases, School of Medicine, Kagoshima University, Kagoshima City, Kagoshima, Japan
    Blood 101:3581-9. 2003
    ..Thus, the modulation of T cell-mediated immunity by regulatory DCs provides a novel therapeutic approach for immunopathogenic diseases...
  38. ncbi Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse
    Katsuaki Sato
    Department of Immunology and Medical Zoology, School of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima City, 890 8520, Kagoshima, Japan
    Immunity 18:367-79. 2003
    ..Thus, the use of rDCs may be therapeutically useful for the treatment of acute GVHD and leukemia relapse in allogeneic BMT...
  39. ncbi Novel reporter T-cell line highly susceptible to both CCR5- and CXCR4-using human immunodeficiency virus type 1 and its application to drug susceptibility tests
    Hiroshi Miyake
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima 890-8520, USA
    J Clin Microbiol 41:2515-21. 2003
    ..Thus, MOCHA cells are an extremely useful tool for detection of R5 and X4 HIV-1 replication and drug susceptibility tests...
  40. ncbi The role of breast cancer resistance protein (BCRP/ABCG2) in cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors
    Xin Wang
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Antivir Chem Chemother 16:213-6. 2005
    ..Thus, BCRP is considered to be a cellular factor that modulates the anti-HIV-1 activity of NRTIs...
  41. ncbi Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates
    Minyi Shi
    Frontier Science Research Center, Kagoshima University, Kagoshima 890 8544, Japan
    Antimicrob Agents Chemother 51:2600-4. 2007
    ..Among the test compounds, zidovudine was found to be the most active. The order of potency was zidovudine > phosphonylmethoxyethoxydiaminopyrimidine = phosphonylmethoxypropyldiaminopurine > tenofovir > or = adefovir > stavudine...
  42. ncbi Production of functionally deficient dendritic cells from HTLV-I-infected monocytes: implications for the dendritic cell defect in adult T cell leukemia
    M Makino
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Virology 274:140-8. 2000
    ..These results suggest that HTLV-I-infected monocytes cannot properly differentiate to DCs and that this might be one of the important mechanisms producing dysfunctional DCs in ATL patients...
  43. ncbi Induction of dendritic cell-mediated immune responses against HIV-1 by antigen-capturing nanospheres in mice
    Masaki Kawamura
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Med Virol 76:7-15. 2005
    ..These results suggest that the use of HIV-1-NS may provide a novel and promising approach for the induction of humoral and cellular immune responses to HIV-1...
  44. ncbi Inhibition of the tax-dependent human T-lymphotropic virus type I replication in persistently infected cells by the fluoroquinolone derivative k-37
    Xin Wang
    Division of Human Retroviruses, Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    Mol Pharmacol 61:1359-65. 2002
    ..These results suggest that the inhibition occurred at the level of HTLV-I LTR-driven Tax expression...
  45. ncbi Targeting of antigen to dendritic cells with poly(gamma-glutamic acid) nanoparticles induces antigen-specific humoral and cellular immunity
    Tomofumi Uto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    J Immunol 178:2979-86. 2007
    ..These results suggest that Ag-carrying gamma-PGA NPs are capable of inducing strong cellular and humoral immune responses and might be potentially useful as effective vaccine adjuvants for the therapy of infectious diseases...
  46. ncbi [Basic approaches to anti-HIV resistance]
    Masanori Baba
    Center for Chronic Viral Research, Faculty of Medicine, Kagoshima University
    Nippon Rinsho 60:763-8. 2002
    ..Furthermore, molecular mechanisms of the resistance induced by some RTIs and PIs have been well understood. Novel inhibitors effective against the resistant mutants have recently been discovered and are under clinical trials...
  47. ncbi Colorimetric lactate dehydrogenase (LDH) assay for evaluation of antiviral activity against bovine viral diarrhoea virus (BVDV) in vitro
    Chiaki Baba
    Department of Dermatology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Antivir Chem Chemother 16:33-9. 2005
    ....
  48. ncbi Eicosapentaenoic acid reduces pulmonary edema in endotoxemic rats
    S Sane
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1, Sakuragaoka, Kagoshima, 890 8520, Japan
    J Surg Res 93:21-7. 2000
    ..At 6 h, wet/dry (W/D) weight ratios were calculated for the lungs to assess pulmonary edema, and neutrophils were counted in pulmonary parenchyma and peripheral blood...
  49. ncbi Epstein-Barr virus involvement is mainly restricted to lymphoepithelial type of gastric carcinoma among various epithelial neoplasms
    Y Kijima
    The First Department of Surgery, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    J Med Virol 64:513-8. 2001
    ..As a result, EBV was associated with only some gastric carcinomas but not with other epithelial neoplasms originating from the lung, esophagus, breast, colon, pancreas, and thyroid in southern Japan...
  50. ncbi Modulation of gene expression related to Toll-like receptor signaling in dendritic cells by poly(gamma-glutamic acid) nanoparticles
    Takayuki Hamasaki
    Division of Antiviral Chemotherapy, Center for Chronic Viral Disease, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan
    Clin Vaccine Immunol 17:748-56. 2010
    ..Thus, gamma-PGA NPs may be an attractive candidate to be developed further as a vaccine adjuvant...
  51. ncbi Modulation of innate and adaptive immunity by biodegradable nanoparticles
    Tomofumi Uto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Immunol Lett 125:46-52. 2009
    ..Thus, gamma-PGA NPs have great potential as an efficient antigen carrier and strong adjuvant to DCs...
  52. ncbi Long-term culture of HIV-1-infected cells with the transcription inhibitor K-37
    Kazunobu Yamataka
    Division of Human Retroviruses, Center for Chronic Viral Diseases Faculty of Medicine, Kagoshima University, Kagoshima 890-8520, Japan
    Antiviral Res 56:85-92. 2002
    ..Furthermore, both M(1) and U(1) had a G to T nucleotide mutation at position -215 in the second nuclear factor of activated T-cells-binding domain (-215 to -203) of the HIV-1 long terminal repeat...
  53. ncbi Inhibition of porcine endogenous retrovirus (PERV) replication by HIV-1 gene expression inhibitors
    Minyi Shi
    Frontier Science Research Center, Kagoshima University, Kagoshima, Japan
    Antiviral Res 83:201-4. 2009
    ..Thus, retroviral gene expression inhibitors may be able to reduce the risk of PERV transmission...
  54. ncbi Induction of potent CD8+ T-cell responses by novel biodegradable nanoparticles carrying human immunodeficiency virus type 1 gp120
    Xin Wang
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    J Virol 81:10009-16. 2007
    ..Thus, gamma-PGA NPs carrying various HIV-1 antigens may have great potential as a novel priming and/or boosting tool in current vaccination regimens for the induction of cellular immune responses...
  55. ncbi Preserved Smad4 expression in the transforming growth factor beta signaling pathway is a favorable prognostic factor in patients with advanced gastric cancer
    C Xiangming
    First Department of Surgery, School of Medicine, Kagoshima University, Japan
    Clin Cancer Res 7:277-82. 2001
    ..05). According to multivariate analysis, Smad4 expression acted as an independent prognostic factor. Smad4 expression, particularly in the TGF-beta pathway, is an effective predictor of outcome for patients with advanced gastric cancer...
  56. ncbi Anti-bovine viral diarrhoea virus activity of novel diphenylmethane derivatives
    Mohammed T A Salim
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Antivir Chem Chemother 20:193-200. 2010
    ..Among them, some diphenylmethane derivatives were found to be selective inhibitors of BVDV...
  57. ncbi Improvement of adaptive immunity by antigen-carrying biodegradable nanoparticles
    Tomofumi Uto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8544, Japan
    Biochem Biophys Res Commun 379:600-4. 2009
    ..Strong antibody production was observed by s.c. immunization, yet no antibody was identified by intranasal immunization. Thus, gamma-PGA NPs are a safe and efficient antigen carrier with unique immunological properties...
  58. ncbi Poly(gamma-glutamic acid) nanoparticles as an efficient antigen delivery and adjuvant system: potential for an AIDS vaccine
    Xin Wang
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Med Virol 80:11-9. 2008
    ..Thus, gamma-PGA nanoparticles encapsulating various antigens may have great potential as novel and efficient protein-based vaccines against infectious diseases, including HIV-1 infection...
  59. ncbi Induction of mucosal IgA following intravaginal administration of inactivated HIV-1-capturing nanospheres in mice
    Masaki Kawamura
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    J Med Virol 66:291-8. 2002
    ..Thus, HIV-NS may have great potential as a prophylactic HIV-1 vaccine and should be examined further for its efficacy in non-human primates...
  60. ncbi HIV-1-infected macrophages induce astrogliosis by SDF-1alpha and matrix metalloproteinases
    Mika Okamoto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan
    Biochem Biophys Res Commun 336:1214-20. 2005
    ..These results indicate that the activated and HIV-1-infected macrophages can indirectly induce astrocyte proliferation through up-regulating SDF-1alpha and MMP production, which implies a mechanism of astrogliosis in HAD...
  61. ncbi Establishment of an in vitro assay system mimicking human immunodeficiency virus type 1-induced neural cell death and evaluation of inhibitors thereof
    Mika Okamoto
    Faculty of Medicine, Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
    J Virol Methods 108:195-203. 2003
    ..These results indicate that this system seems to be a useful tool for the evaluation of compounds against HIV-1-induced neural cell death...
  62. ncbi Association of CD40 ligand expression on HTLV-I-infected T cells and maturation of dendritic cells
    M Makino
    Division of Human Retrovirus, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan
    Scand J Immunol 54:574-81. 2001
    ..The CD40L+ T-cell-induced maturation was blocked by anti-CD40L antibody. Therefore, the lack of CD40L expression on HTLV-I-infected T cells may be associated with the development of ATL...
  63. ncbi Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5'-DFUR cytotoxicity
    Kengo Tsuneyoshi
    Department of Molecular Oncology, Field of Oncology, Course of Advanced Therapeutics, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima 890-8520, Japan
    Cancer Lett 244:239-46. 2006
    ..These results suggest that AZT enhances the cytotoxic effect of 5'-DFUR on U937 cells by upregulating TP activity in addition to its inhibition of thymidine kinase (TK) activity and reduction of intracellular dTTP pools...
  64. ncbi IgG responses to intranasal immunization with cholera-toxin-immobilized polymeric nanospheres in mice
    Tatsuo Kaneko
    Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan
    J Biomater Sci Polym Ed 15:661-9. 2004
    ..Thus, polymeric NS may be an effective substrate to covalently immobilize antigen on their surface, steadily inducing a high level of IgG production in response to the intranasal administration...
  65. ncbi Anti-bovine viral diarrhoea virus and hepatitis C virus activity of the cyclooxygenase inhibitor SC-560
    Mika Okamoto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Antivir Chem Chemother 20:47-54. 2009
    ..A number of compounds were examined for their inhibitory effect on bovine viral diarrhoea virus (BVDV) replication in cell cultures and found that some cyclooxygenase (COX) inhibitors had antiviral activity against the virus...
  66. ncbi Highly enhanced expression of CD70 on human T-lymphotropic virus type 1-carrying T-cell lines and adult T-cell leukemia cells
    Masanori Baba
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1, Sakuragaoka, Kagoshima 890 8544, Japan
    J Virol 82:3843-52. 2008
    ..Since CD70 expression is strictly restricted in normal tissues, such as highly activated T and B cells, CD70 appears to be a potential target for effective antibody therapy against ATL...
  67. ncbi High-sensitivity analysis of naturally occurring sugar chains, using a novel fluorescent linker molecule
    Masaki Sato
    Department of Nanostructure and Advanced Materials, Kagoshima University, Kohrimoto, Japan
    J Biochem 146:33-41. 2009
    ..Immobilization of the FLC onto gold-coated chips, and their subsequent SPR analyses were successively accomplished, as had been performed previously using non-fluorescent ligand conjugates...
  68. ncbi Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent Anti-HIV-1 activity
    Shinichi Imamura
    Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Yodogawa ku, Osaka 532 8686, Japan
    J Med Chem 49:2784-93. 2006
    ..1 nM, EC(90) = 13 nM) and exhibited a good pharmacokinetic profile in monkeys (BA = 29%). This compound has been chosen as a clinical candidate for further development...
  69. ncbi Protein direct delivery to dendritic cells using nanoparticles based on amphiphilic poly(amino acid) derivatives
    Takami Akagi
    Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2 1 Yamadaoka, Suita 565 0871, Japan
    Biomaterials 28:3427-36. 2007
    ..This system has potential application as a universal delivery system for protein-based vaccines capable of inducing cytotoxic T lymphocyte (CTL)...
  70. ncbi Synthesis and anti-human immunodeficiency virus activity of 4'-branched (+/-)-4'-thiostavudines
    Hiroki Kumamoto
    School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
    J Med Chem 49:7861-7. 2006
    ..6 and 0.74 microM, respectively. The activity of 29 was comparable to that of stavudine, but 29 was not as active as 4. Optical resolution of 29 was briefly examined...
  71. ncbi Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog
    Elijah Paintsil
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, SHM B226, New Haven, CT 06520, USA
    Antimicrob Agents Chemother 51:3870-9. 2007
    ..4'-Ed4T is a promising antiviral candidate for HIV type 1 chemotherapy...
  72. ncbi Synthesis and anti-HIV activity of 4'-substituted 4'-thiothymidines: a new entry based on nucleophilic substitution of the 4'-acetoxy group
    Kazuhiro Haraguchi
    School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, Japan
    J Med Chem 51:1885-93. 2008
    ..It is noteworthy that 36 and 37 were also inhibitory against replication of HIV variant resistant to 3TC (HIV-1 M184V), being as potent as against HIV-1 IIIB...
  73. ncbi Highly selective action of triphosphate metabolite of 4'-ethynyl D4T: a novel anti-HIV compound against HIV-1 RT
    Guangwei Yang
    Department of Pharmacology, School of Medicine, Yale University, 333 Cedar Street, New Haven, CT 06520, USA
    Antiviral Res 73:185-91. 2007
    ..4'-Ed4TTP showed much less inhibitory effects toward major host DNA polymerases. Overall, our results suggest that 4'-Ed4TTP is the active form for anti-HIV-1 activity via its inhibitory effect against RT...
  74. ncbi Highly potent and orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activities of 1-benzazocine derivatives containing a sulfoxide moiety
    Masaki Seto
    Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 2 17 85 Jusohonmachi, Yodogawa ku, Osaka 532 8686, Japan
    J Med Chem 49:2037-48. 2006
    ..The synthesis and biological activity of the 1-benzazocine compound (S)-(-)-5b and its related derivatives are described...
  75. ncbi Studies of non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: synthesis and structure-activity relationships of 2-cyano and 2-hydroxy thiazolidenebenzenesulfonamide derivatives
    Naoyuki Masuda
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Bioorg Med Chem 13:949-61. 2005
    ..Compound 11g (YM-215389), a combination of 2-hydroxyphenyl and 4-chloro-5-isopropylthiazole moieties, proved to be the most active against both K103N and Y181C RTs with IC50 values of 0.043 and 0.013 microM, respectively...
  76. ncbi Orally active CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological activities of 1-benzazepine derivatives containing a sulfoxide moiety
    Masaki Seto
    Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 2 17 85 Jusohonmachi, Yodogawa ku, Osaka 532 8686, Japan
    Bioorg Med Chem 13:363-86. 2005
    ..In addition, we established the synthesis of (S)-4r and (S)-4w by asymmetric oxidation with titanium-(S)-(-)-1,1'-bi-2-naphthol complex...
  77. ncbi Studies of nonnucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Design and synthesis of thiazolidenebenzenesulfonamides
    Naoyuki Masuda
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Bioorg Med Chem 12:6171-82. 2004
    ..These results confirm the important role of the substituents at these positions and the thiazolidenebenzenesulfonamide motif as a valuable lead series for the next generation NNRTIs...
  78. ncbi Orally active CCR5 antagonists as anti-HIV-1 agents 2: synthesis and biological activities of anilide derivatives containing a pyridine N-oxide moiety
    Masaki Seto
    Medicinal Chemistry Research Laboratries, Pharmaceutical Research Division, Takeda Chemical Industries Ltd Osaka, Japan
    Chem Pharm Bull (Tokyo) 52:818-29. 2004
    ..In particular, compound (S)-5s showed the most potent CCR5 antagonistic activity (IC(50)=7.2 nM) and inhibitory effect (IC(50)=5.4 nM) in the fusion assay, together with good pharmacokinetic properties in rats...
  79. ncbi Synthesis and anti-HIV activity of 4'-cyano-2',3'-didehydro-3'-deoxythymidine
    Kazuhiro Haraguchi
    School of Pharmaceutical Sciences, Showa University, Shinagawa ku, Tokyo, Japan
    Nucleosides Nucleotides Nucleic Acids 23:647-54. 2004
    ..Evaluation of the anti-HIV activity of 9 showed that this compound is much less potent than the recently reported 2',3'-didehydro-3'-deoxy-4'-(ethynyl)thymidine (1)...
  80. ncbi CCR5 antagonists as anti-HIV-1 agents. Part 2: Synthesis and biological evaluation of N-[3-(4-benzylpiperidin-1-yl)propyl]-N,N'-diphenylureas
    Shinichi Imamura
    Pharmaceutical Research Division, Takeda Chemical Industries, Ltd, 2 17 85, Jusohonmachi, Yodogawa ku, Osaka 532 8686, Japan
    Bioorg Med Chem 12:2295-306. 2004
    ....
  81. ncbi CCR5 antagonists as anti-HIV-1 agents. 1. Synthesis and biological evaluation of 5-oxopyrrolidine-3-carboxamide derivatives
    Shinichi Imamura
    Pharmaceutical Research Division, Takeda Chemical Industries Ltd, 2 17 85 Jusohonmachi, Yodogawa ku, Osaka 532 8686, Japan
    Chem Pharm Bull (Tokyo) 52:63-73. 2004
    ..038 microM) was found to be effective for improving CCR5 affinity. Compound 10i, 11b, and 12e also inhibited CCR5-using HIV-1 envelope-mediated membrane fusion with IC(50) values of 0.44, 0.19, and 0.49 microM, respectively...
  82. ncbi Synthesis and anti-HIV-1 activity of novel 10-thiaisoalloxazines, a structural analog of C-5 and/or C-6 substituted pyrimidine acyclonucleoside
    Takanori Miyashita
    Biochemical Division, Yamasa Corporation, Chiba, Japan
    Chem Pharm Bull (Tokyo) 51:630-4. 2003
    ..Among the derivatives, compounds 6, 7, and 8 bearing an alkoxymethyl moiety at the N-1 position exhibited modest inhibitory activity towards the cytotopathic effect of HIV-1...
  83. ncbi TRAIL-transduced dendritic cells protect mice from acute graft-versus-host disease and leukemia relapse
    Katsuaki Sato
    Laboratory for Dendritic Cell Immunobiology, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Kanagawa, Japan
    J Immunol 174:4025-33. 2005
    ..Thus, gene transfer of TRAIL to DCs is a novel modality for the treatment of acute GVHD and leukemia relapse by selective targeting of pathogenic T cells and leukemic cells...
  84. ncbi Orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activity of 1-benzothiepine 1,1-dioxide and 1-benzazepine derivatives containing a tertiary amine moiety
    Masaki Seto
    Medicinal Chemistry Research Laboratries, Pharmaceutical Research Division, Takeda Chemical Industries Ltd, Osaka, Japan
    Chem Pharm Bull (Tokyo) 52:577-90. 2004
    ..7 nM) and inhibitory effect (IC(50)=1.2 nM) on membrane fusion, together with good pharmacokinetic properties in rats. The synthesis of 1-benzothiepine 1,1-dioxide and 1-benzazepine derivatives and their biological activity are described...
  85. ncbi 4'-Ethynylstavudine (4'-Ed4T) has potent anti-HIV-1 activity with reduced toxicity and shows a unique activity profile against drug-resistant mutants
    Hiromichi Tanaka
    School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    Antivir Chem Chemother 16:217-21. 2005
    ..The study of 4'-Ed4T against various drug-resistant HIV-1 mutants has disclosed its unique activity profile...
  86. ncbi CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological evaluation of piperidine-4-carboxamide derivatives
    Shinichi Imamura
    Pharmaceutical Research Division, Takeda Pharmaceutical Co Ltd, 2 17 85, Jusohonmachi, Yodogawa ku, Osaka 532 8686, Japan
    Bioorg Med Chem 13:397-416. 2005
    ..The selected compound 11f showed excellent antiviral activity against CCR5-using HIV-1 replication in human peripheral blood mononuclear cells (EC50=0.59 nM) and an acceptable pharmacokinetic profile in dogs...
  87. ncbi Synthesis of (+/-)-4'-ethynyl and 4'-cyano carbocyclic analogues of stavudine (d4T)
    Hiroki Kumamoto
    School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    Nucleosides Nucleotides Nucleic Acids 24:73-83. 2005
    ..The ethynyl or cyano group of 8 and 9 were prepared, after the introduction of thymine base to 16, by manipulation of the ester function. Evaluation of the anti-HIV activity of 8 and 9 was also carried out...
  88. ncbi Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile 2006 (1st edition)
    Hugh J Field
    Antivir Chem Chemother 17:111-2. 2006
  89. ncbi Synthesis of a highly active new anti-HIV agent 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine
    Kazuhiro Haraguchi
    School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
    Bioorg Med Chem Lett 13:3775-7. 2003
    ..The compounds were assayed for their ability to inhibit the replication of HIV in cell culture. The 4'-ethynyl analogue (15) was found to be more potent and less toxic than the parent compound stavudine...
  90. ncbi AIDS vaccine: Intranasal immunization using inactivated HIV-1-capturing core-corona type polymeric nanospheres
    Takami Akagi
    Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Japan
    J Control Release 109:49-61. 2005
    ..These results suggest that HIV-NS provides an efficient vaccine delivery system for the induction of a mucosal immune response and the development of a mucosal vaccine...
  91. ncbi Mucosal immunization with inactivated HIV-1-capturing nanospheres induces a significant HIV-1-specific vaginal antibody response in mice
    Takami Akagi
    Japan Immunoresearch Laboratories, Takasaki, Gunma, Japan
    J Med Virol 69:163-72. 2003
    ..Intranasal immunization with HIV-NS should be further pursued for its potential as an HIV-1 prophylactic vaccine...
  92. ncbi A new approach to the synthesis of 4'-carbon-substituted nucleosides: development of a highly active anti-HIV agent 2', 3'-didehydro-3'-deoxy-4'-ethynylthymidine
    Kazuhiro Haraguchi
    School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    Nucleosides Nucleotides Nucleic Acids 24:343-7. 2005
    ..Evaluation of their ability to inhibit the replication of HIV in cell culture showed that 4'-ethynyl-d4T (19) is more potent and less toxic than the parent compound d4T...
  93. ncbi [Development of vaccine adjuvants using polymeric nanoparticles and their potential applications for anti-HIV vaccine]
    Takami Akagi
    Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Yamadaoka, Suita City, Japan
    Yakugaku Zasshi 127:307-17. 2007
    ..These HIV-1-capturing nanospheres and protein-loaded gamma-PGA nanoparticles have shown unique potential as vaccine carriers...
  94. ncbi Synthesis and antiviral activities of 1'-carbon-substituted 4'-thiothymidines
    Kazuhiro Haraguchi
    School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Bioorg Med Chem 12:5309-16. 2004
    ..Among the deprotected 1'-branched 4'-thiothymidines (20-25), the 1'-methyl analogue 20 showed the most potent anti-HSV-1 activity, but it was much less active than the parent compound 4'-thiothymidine...
  95. ncbi Gamma-carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity
    Kumiko Sako
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Bioorg Med Chem 16:3780-90. 2008
    ..Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-gamma-carboline), with the EC(50) of 0.26 microM...
  96. ncbi Synthesis of benzodithiol-2-yl-substituted nucleoside derivatives as lead compounds having anti-bovine viral diarrhea virus activity
    Kohji Seio
    Frontier Collaborative Research Center and Department of Life Science, Tokyo Institute of Technology, Nagatsuta, Midori-ku, Yokohama 226-8501, Japan
    J Med Chem 47:5265-75. 2004
    ..Since BVDV has been recognized as a surrogate for human hepatitis C virus (HCV), the BDT-modified nucleosides might become a new class of lead compounds to find nucleoside-type anti-HCV agents such as ribavirin...
  97. ncbi Comparison of the phosphorylation of 4'-ethynyl 2',3'-dihydro-3'-deoxythymidine with that of other anti-human immunodeficiency virus thymidine analogs
    Chih Hung Hsu
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Antimicrob Agents Chemother 51:1687-93. 2007
    ..Qualitatively, the metabolism of 4'-ethynyl D4T is more similar to that of AZT than to that of its progenitor, D4T...
  98. ncbi Fusion of mature dendritic cells and human T-lymphotropic virus type I infected T cells: its efficiency as an antigen-presenting cell
    Satoshi Shimokubo
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, 189-0002, Japan
    Virology 301:13-20. 2002
    ..The results suggest that fusion DC-T cells produce functionally competent Ag-presenting cells and may be a likely candidate for immunotherapeutic use...