Research Topics
Genomes and Genes | Takashi AikouSummaryAffiliation: Kagoshima University Country: Japan Publications
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Publications
[A case of advanced gastric cancer with multiple liver metastases completely responding to combination of paclitaxel and S-1]Sumiya Ishigami
Dept of Surgical Oncology, Digestive Surgery Kagoshima University School of Medicine
Gan To Kagaku Ryoho 35:1197-9. 2008..She has been well without tumor re-growth for 4 years. The combination of PTX and S-1 may be an effective regimen for gastric cancer with liver metastases...- Snail plays a key role in E-cadherin-preserved esophageal squamous cell carcinomaShoji Natsugoe
Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
Oncol Rep 17:517-23. 2007..035). Snail appears to play a key role in preserved E-cadherin expression. Further studies on other molecules in the pathways related to reduced E-cadherin expression in ESCC from the view-point of EMT are necessary... - Can sentinel node navigation surgery reduce the extent of lymph node dissection in gastric cancer?T Aikou
First Department of Surgery, Kagoshima University School of Medicine, Japan
Ann Surg Oncol 8:90S-93S. 2001..SNNS for gastric cancer is a promising technique; further study of various anatomic and pathologic factors will indicate whether it can be used to determine the extent of lymphadenectomy necessary in patients with early gastric cancer... - Sentinel lymph node mapping with GI cancerTakashi Aikou
Department of Surgical Oncology and Digestive Surgery, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Cancer Metastasis Rev 25:269-77. 2006..Although more evidence from large-scale multicenter clinical trials is required, SLN mapping may be very useful for individualizing multi-modal treatment for esophageal cancer and might be widely acceptable even for GI cancer... 
Vascular endothelial growth factor-C and -D expression correlates with lymph node micrometastasis in pN0 early gastric cancerTakaaki Arigami
Department of Surgical Oncology and Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
J Surg Oncol 99:148-53. 2009..The present study investigates the expression of VEGF-C and -D in early gastric cancer and analyzes its relationship to lymph node micrometastasis determined by reverse transcription-polymerase chain reaction (RT-PCR)...- Salvage gastrectomy following a combination of biweekly paclitaxel and S-1 for stage IV gastric cancerSumiya Ishigami
Digestive Surgery, Surgical Oncology, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima, 890, Japan
J Gastrointest Surg 12:1370-5. 2008..We investigated the clinical benefits of salvage gastrectomy for stage IV gastric cancer patients whose distant lesions showed complete response after chemotherapy... - Improvement in radiosensitivity using small interfering RNA targeting p53R2 in esophageal squamous cell carcinomaNaoya Yokomakura
Department of Surgical Oncology and Digestive Surgery, Graduate School of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
Oncol Rep 18:561-7. 2007..This protocol could potentially improve the efficacy of radiation therapy... - Carcinoembryonic antigen messenger RNA expression in blood can predict relapse in gastric cancerSumiya Ishigami
Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
J Surg Res 148:205-9. 2008..To clarify the clinical implications of intraoperative carcinoembryonic antigen (CEA) mRNA copy number in peripheral blood samples from gastric cancer patients... - The successfully curative treatment of advanced gastric adenocarcinoma with multiple liver metastases and paraaortic lymph node metastases by salvage operation following the biweekly paclitaxel and S-1 combination chemotherapy: a case reportKen Sasaki
Department of Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
Hepatogastroenterology 54:2421-4. 2007..Biweekly paclitaxel and S-1 combination chemotherapy has been used safely and its administration may be continued for a long time in an outpatient clinic setting for the treatment of advanced gastric cancer... - Predictive value of p53 and 14-3-3sigma for the effect of chemoradiation therapy on esophageal squamous cell carcinomaHiroshi Okumura
Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, Kagoshima, Japan
J Surg Oncol 91:84-9. 2005.... - Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinomaHiroyuki Takatori
Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
Oncol Rep 13:697-701. 2005..COX-2 mRNA expression in biopsy specimens was closely related to CRT effectiveness. Examination of COX-2 mRNA expression is useful for predicting the effect of CRT in patients with ESCC... - Expression of CXCL12 and its receptor CXCR4 in esophageal squamous cell carcinomaKen Sasaki
Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890 8520, Japan
Oncol Rep 21:65-71. 2009..Evaluation of CXCL12 expression is useful for determining tumor properties, including nodal metastasis and prognosis in patients with ESCC... - Roxithromycin inhibits constitutive activation of nuclear factor {kappa}B by diminishing oxidative stress in a rat model of hepatocellular carcinomaShinichi Ueno
Department of Surgical Oncology and Digestive Surgery, School of Medicine, Kagoshima University, Kagoshima, Japan
Clin Cancer Res 11:5645-50. 2005..We investigated the suppressive effect of roxithromycin on accelerated hepatocellular carcinoma growth in a rat hepatocarcinogenetic model and compared results with effects from TNP-470... - Clinical significance of circulating tumor cells in blood by molecular detection and tumor markers in esophageal cancerSaburo Nakashima
First Department of Surgery, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
Surgery 133:162-9. 2003..CONCLUSIONS: CEA mRNA detected by RT-PCR was more predictive of tumor recurrence than serum tumor markers. Effective adjuvant therapy is recommended for patients with CEA mRNA positive expression... - Successful treatment of advanced gastric cancer by surgical resection following combination chemotherapy with oral S-1 and biweekly paclitaxelAkihiro Nakajo
Department of Digestive Surgery and Surgical Oncology, Kagoshima University Graduate School of Medical and Dental Science, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
Gastric Cancer 10:58-62. 2007..The tumor was pathologically diagnosed as pT2, pN0, P0, M0, CY0, and p-stage II. The patient is healthy over 4 years after surgery without recurrence... - CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancerTakaaki Arigami
Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890 8520, Japan
Int J Oncol 35:19-24. 2009..0021). Assessment of CCR7 and CXCR4 expression in gastric cancer is a useful tool for predicting lymph node metastatic status including LNMM... - Overexpression of vascular endothelial growth factor-C correlates with lymph node micrometastasis in submucosal esophageal cancerMasataka Matsumoto
Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
J Gastrointest Surg 10:1016-22. 2006..0001 and P < 0.01, respectively). The present findings indicate that in ESCC with submucosal invasion, VEGF-C overexpression of the primary tumor is a strong high risk factor for lymph node metastasis, including LMM... - Clinical implication of CXCL12 expression in gastric cancerSumiya Ishigami
Digestive Surgery Surgical Oncology, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
Ann Surg Oncol 14:3154-8. 2007..This study immunohistochemically investigated CXCL12 expression in gastric cancer and evaluated its association with clinical factors, including patient prognosis... - Prognostic factors in patients with submucosal esophageal cancerShoji Natsugoe
First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
J Gastrointest Surg 8:631-5. 2004.... - Clinical significance of CEA-mRNA expression in peritoneal lavage fluid from patients with gastric cancerKoki Tokuda
First Department of Surgery, Kagoshima University School of Medicine, Kagoshima 890-8520, Japan
Int J Mol Med 11:79-84. 2003..Adjuvant therapy may be advisable for the gastric cancer patients with positive findings of peritoneal lavage by RT-PCR... - Sentinel node micrometastases have high proliferative potential in gastric cancerShigehiro Yanagita
Course of Advanced Therapeutics, Field of Oncology, Department of Surgical Oncology and Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
J Surg Res 145:238-43. 2008..quot; The present study examines the frequency and proliferative activity of such metastases with focus on the SNs of gastric cancer... - Carcinoembryonic antigen messenger RNA expression in blood predicts recurrence in esophageal cancerTetsuro Setoyama
Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University, Graduate School of Medical and Dental Science, Kagoshima, Japan
Clin Cancer Res 12:5972-7. 2006..We conducted a longitudinal analysis of the relationship between ITC in blood during follow-up and clinicopathologic findings in patients with esophageal squamous cell carcinoma... - alpha-catenin is a significant prognostic factor than E-cadherin in esophageal squamous cell carcinomaTetsuro Setoyama
Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University, Graduate School of Medical and Dental Science, Sakuragaoka, Kagoshima, Japan
J Surg Oncol 95:148-55. 2007..The purpose of the present study was to analyze clinicopathologic variables in esophageal squamous cell carcinoma (ESCC) according to expression of E-cadherin and alpha-catenin which play an important role in cell adhesion... - Biological aggressiveness of alpha-fetoprotein (AFP)-positive gastric cancerSumiya Ishigami
First Department of Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890, Japan
Hepatogastroenterology 53:338-41. 2006..However, little information regarding the clinicopathological and biological behaviors of APGC is available due to the small size of reported series... - A multicenter phase II study of biweekly paclitaxel and S-1 combination chemotherapy for unresectable or recurrent gastric cancerAkihiro Nakajo
Department of Surgical Oncology and Digestive Surgery, Kagoshima University Graduate School of Medicine, Kagoshima, Japan
Cancer Chemother Pharmacol 62:1103-9. 2008..The maximum tolerated dose for this regimen had been established previously in a Phase I study performed in Japanese patients... - Distribution of lymph node metastasis including micrometastasis in gastric cancer with submucosal invasionHiroshi Higashi
First Department of Surgery, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
World J Surg 27:455-9. 2003..When planning minimally invasive treatment for submucosal gastric cancer, it is important to understand the distribution of lymph node metastasis, including micrometastasis, according to tumor location... 
Significance of Twist expression and its association with E-cadherin in esophageal squamous cell carcinomaKen Sasaki
Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
J Exp Clin Cancer Res 28:158. 2009..The purpose of this study is to evaluate the clinical significance of Twist and E-cadherin expression in ESCC...- Expression of p53R2 is related to prognosis in patients with esophageal squamous cell carcinomaHiroshi Okumura
Department of Surgical Oncology and Digestive Surgery, Graduate School of Medicine, Kagoshima University, Sakuragaoka, Kagoshima, Japan
Clin Cancer Res 12:3740-5. 2006..In the present study, we analyzed the expression and clinicopathologic significance of p53 and p53R2 in esophageal squamous cell carcinoma... - Usefulness of sentinel node biopsy in laparoscopic partial gastrectomy for early gastric cancerSumiya Ishigami
Surgical Oncology, Digestive Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890, Japan
Hepatogastroenterology 54:2164-6. 2007..Five patients having early gastric cancer were treated using laparoscopic partial gastrectomy combined with sentinel lymph node biopsy... - Clinical and pathological features in T-cell gastric lymphoma associated with human T-cell leukemia virus type 1 (HTLV-1) in comparison with B-cell gastric lymphomaSumiya Ishigami
First Department of Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
Hepatogastroenterology 49:1737-41. 2002..We investigated clinical features of T-cell gastric lymphomas associated with human T-cell leukemia virus type 1 (HTLV-1)... - Infiltration of antitumor immunocytes into the sentinel node in gastric cancerSumiya Ishigami
First Department of Surgery, Kagoshima University School of Medicine, Sakuragaoka, Kagoshima, Japan
J Gastrointest Surg 7:735-9. 2003..Studies in progress will help to identify immunologic paralysis of the SN in various types of cancer. Attention must therefore be paid to organ specificity... - Bone marrow micrometastasis detected by RT-PCR in esophageal squamous cell carcinomaShoji Natsugoe
First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
Oncol Rep 10:1879-83. 2003..0% and 47.3%, respectively. Recurrence and survival rates were poorer in patients with RT-PCR positivity, although the differences were not significant. A larger study is required to clarify the clinical impact of BMM... - Clinicopathological and biological characteristics of esophageal squamous cell carcinoma associated with head and neck cancerMasataka Matsumoto
Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Oncology 67:98-102. 2004..The aim of this study was to clarify clinicopathological and biological characteristics of esophageal squamous cell carcinoma associated with head and neck cancer (HN group)... - Multiple primary carcinomas with esophageal squamous cell cancer: clinicopathologic outcomeShoji Natsugoe
Department of Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, 890 8520 Kagoshima, Japan
World J Surg 29:46-9. 2005..0005). Meticulous follow-up after treatment of a first cancer should be required to detect other early-stage carcinomas... - Preoperative assessment of the depth of early gastric cancer invasion by transabdominal ultrasound sonography (TUS): a comparison with endoscopic ultrasound sonography (EUS)Sumiya Ishigami
First Department of Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890, Japan
Hepatogastroenterology 51:1202-5. 2004..We retrospectively analyzed the clinical efficacy of preoperative evaluation by TUS in early gastric cancer in comparison with endoscopic ultrasound sonography (EUS)... - Biological properties of biopsy specimens are useful for predicting lymph node micrometastasis in esophageal carcinomaSaburo Nakashima
First Department of Surgery, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
Anticancer Res 22:2951-6. 2002..CONCLUSION: The expression of CD1 and DG1 in biopsy specimens may offer useful information on lymph node metastasis, including MM in esophageal carcinoma... - Roux-en-Y reconstruction with stapled distal jejunal pouch after total gastrectomySumiya Ishigami
Digestive Surgery and Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan
Am Surg 76:526-8. 2010..This procedure may improve postoperative malnutrition after total gastrectomy according to our feasible study. A multicenter randomized trial of this approach comparing with Roux-en-Y reconstruction without a pouch is ongoing... - Expression of CXCL12 and its receptor CXCR4 correlates with lymph node metastasis in submucosal esophageal cancerKen Sasaki
Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
J Surg Oncol 97:433-8. 2008..We examined their expression and microvessel density (MVD) in submucosal esophageal squamous cell carcinoma (ESCC) and analyzed their connection to clinicopathological findings including lymph node micrometastasis (LMM)... - Prognostic value of CCR7 expression in gastric cancerSumiya Ishigami
Department of Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan
Hepatogastroenterology 54:1025-8. 2007..However, there is little information regarding the clinical implications of CCR7-positive gastric cancer... - Area of nodal metastasis and radioisotope uptake in sentinel nodes of upper gastrointestinal cancerHideo Arima
Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University School of Medical and Dental Science, Kagoshima, Japan
J Surg Res 135:250-4. 2006..As few studies have examined relationships between metastatic area and radioisotope uptake in sentinel nodes, the present study examined this relationship for gastric and esophageal cancers... - Lymph node micrometastasis and lymphatic mapping determined by reverse transcriptase-polymerase chain reaction in pN0 gastric carcinomaMasataka Matsumoto
First Department of Surgery, Kagoshima University School of Medicine, Japan
Surgery 131:630-5. 2002..CONCLUSIONS: We demonstrated the relationship between LMM and clinicopathologic factors, especially in pT1 tumor. The mapping of LMM may prove useful for selecting the optimal treatment... - Carcinoembryonic antigen messenger RNA expression using nested reverse transcription-PCR in the peripheral blood during follow-up period of patients who underwent curative surgery for biliary-pancreatic cancer: longitudinal analysesYuko Mataki
Department of Oncology, Kagoshima University School of Medicine, Kagoshima, Japan
Clin Cancer Res 10:3807-14. 2004..CONCLUSIONS: During the follow-up of patients who undergo a curative operation for biliary-pancreatic cancer, CEA mRNA expression in the peripheral blood might be a useful and early indicator of relapse... - Morphological distribution of metastatic foci in sentinel lymph nodes with gastric cancerShigehiro Yanagita
Department of Surgical Oncology and Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Ann Surg Oncol 15:770-6. 2008..The purpose of this study was to clarify the clinical significance of the morphological distribution of cancer cells in SNs according to metastasis (MA), MM, and ITC... - Interleukin 8 in human hepatocellular carcinoma correlates with cancer cell invasion of vessels but not with tumor angiogenesisFumitake Kubo
Course of Advanced Therapeutics, Field of Oncology, Department of Surgical Oncology and Digestive Surgery, KagoshimaUniversity Graduate School of Medicine and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
Ann Surg Oncol 12:800-7. 2005..Angiogenic factor seems necessary for the development of hepatocellular carcinoma (HCC), which is a hypervascular malignancy. This study examined the expression of interleukin (IL)-8, a potent angiogenic factor, in HCC samples... - CD3 zeta expression of regional lymph node and peripheral blood lymphocytes in gastric cancerSumiya Ishigami
First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
Anticancer Res 24:2123-6. 2004.... - Intramammary sentinel lymph node in patients with breast cancer: report of four casesYuko Kijima
Department of Surgical Oncology, Breast and Endocrine Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
Surg Today 38:536-40. 2008..We should keep in mind the presence of intramammary SN in regions apart from the primary tumor, particularly when performing breast conservative surgery... - Efficacy of anatomic resection vs nonanatomic resection for small nodular hepatocellular carcinoma based on gross classificationShinichi Ueno
Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medicine and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, Japan
J Hepatobiliary Pancreat Surg 15:493-500. 2008..Nonanatomic resection or ablation has also been used as therapy for small HCCs. We studied the effectiveness of anatomic resection for small nodular HCCs, especially from the viewpoints of tumor size and gross classification... - A case of leptomeningeal carcinomatosis from esophageal basaloid carcinoma diagnosed by quantitative reverse transcription-polymerase chain reaction for carcinoembryonic antigenHiroshi Okumura
Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
J Gastroenterol 40:87-93. 2005.... - Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinomaYasuto Uchikado
Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
Clin Cancer Res 11:1174-80. 2005..The purpose of the present study was to evaluate the clinical significance of E-cadherin and Slug expression in ESCC... - Molecular detection of free cancer cells in pleural lavage fluid from esophageal cancer patientsShoji Natsugoe
First Department of Surgery, Kagoshima University School of Medicine, Sakuragaoka, Kagoshima 890 8520, Japan
Int J Mol Med 12:771-5. 2003..Although disease recurred in almost all patients exhibiting CEA-mRNA expression, due to the relatively small sample in the present study the clinical significance must be investigated further in a larger number of patients... - Reconstruction of recurrent laryngeal nerve with involvement by metastatic node in esophageal cancerShoji Natsugoe
Department of Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
Ann Thorac Surg 79:1886-9. 2005..We evaluated recurrent laryngeal nerve reconstruction in patients with lymph node metastasis infiltrating the recurrent laryngeal nerve... - Clinical impact of micrometastasis of the lymph node in gastric cancerSumiya Ishigami
First Department of Surgery, Kogoshima University School of Medicine, Kagoshima, Japan
Am Surg 69:573-7. 2003..05). Based on the present results the presence of lymph node micrometastasis may provide a more accurate indication for surgical outcome in gastric cancer patients at the same clinical stage... - Initial metastatic, including micrometastatic, sites of lymph nodes in esophageal squamous cell carcinomaShoji Natsugoe
First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
J Surg Oncol 89:6-11. 2005..It is important to identify the initial lymph node metastasis when performing less invasive surgery. The purpose of the present study was to analyze locations of solitary lymph node metastasis and micrometastasis in esophageal carcinoma... - P53 and MIB-1 expression in gastrointestinal stromal tumor (GIST) of the stomachYoichi Hata
First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
Hepatogastroenterology 53:613-5. 2006..Especially, p53 expression of the tumor may indicate patients having a high risk of recurrence... - Pancreatic mucinous cyst adenocarcinoma producing CA 19-9. A case reportSumiya Ishigami
Gastrointestinal Surgery, Surgical Oncology, Kagoshima University School of Medicine, Japan
JOP 8:228-31. 2007..We herein present a rare case of a mucinous cystic neoplasm of the pancreas producing CA 19-9 and the clinical implications are discussed... - The utility of rapid diagnosis of lymph node metastasis in gastric cancer using a multiplex real-time reverse transcription polymerase chain reaction assayShigehiro Yanagita
Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Oncology 77:205-11. 2009..The purpose of this study was to evaluate the utility of a prototype RT-PCR assay run on the Cepheid SmartCycler system compared to conventional RT-PCR using the LightCycler system. Patients and.. - Clinical significance of nuclear expression of spleen tyrosine kinase (Syk) in gastric cancerHiroshi Nakashima
Department of Surgical Oncology and Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Cancer Lett 236:89-94. 2006..Loss of Syk expression was closely related to the malignant property of gastric cancer in the context of tumor depth and lymph node metastasis, especially in early gastric cancer... - Endosonographic detection of mediastinal lymph node metastasis in superficial carcinoma of the esophagus: assessment by type classification and histogramFuminori Sakamoto
The First Department of Surgery, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
J Gastroenterol 39:7-13. 2004..3%, 100%, and 98.2%, respectively. CONCLUSIONS: Type classification assisted by histography improved the diagnostic accuracy of mediastinal lymph node metastasis in SEC... - Tumor-associated macrophage (TAM) infiltration in gastric cancerSumiya Ishigami
First Department of Surgery, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890, Japan
Anticancer Res 23:4079-83. 2003..Tumor-associated macrophages (TAMs) are defined as macrophages that migrate into the tumor stroma. TAMs are known to directly or indirectly affect immune suppression. TAMs have not previously been reported in gastric cancer... - Disseminated cancer cells in the blood and expression of sialylated antigen in gastric cancerShin-ichi Sumikura
First Department of Surgery, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, 890, Kagoshima, Japan
Cancer Lett 200:77-83. 2003..01) than that of CEA-mRNA alone (p=0.02). CONCLUSION: Analyzing both DCC and sLeX expression in gastric cancer may enable more accurate prediction of postoperative recurrence... - Analysis of T-helper type 1 and 2 cells and T-cytotoxic type 1 and 2 cells of sentinel lymph nodes in breast cancerKatsuhiko Ehi
Digestive Surgery Surgical Oncology, Kagoshima University School of Medicine, Kagoshima 890 8520, Japan
Oncol Rep 19:601-7. 2008..Moreover, the immunologic interaction between the primary site and regional lymph nodes may serve as useful criteria for identifying sentinel nodes... - Evaluation of sentinel node concept in gastric cancer based on lymph node micrometastasis determined by reverse transcription-polymerase chain reactionTakaaki Arigami
Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Ann Surg 243:341-7. 2006..To determine the adequacy of sentinel node (SN) concept based on micrometastasis using immunohistochemistry (IHC) and reverse transcription-polymerase chain reaction (RT-PCR) in gastric cancer... - Biologic and imaging diagnosis of lymph node metastasis in esophageal carcinomaShoji Natsugoe
First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
J Surg Oncol 81:25-32. 2002..We prospectively evaluated lymph node metastasis diagnosed by biologic and imaging means in patients with esophageal carcinoma... - Impact of vascular endothelial growth factor-C and -D expression in human pancreatic cancer: its relationship to lymph node metastasisHiroshi Kurahara
Division of Surgical Oncology, Department of Oncology and Research Center for Life Science Resources, Kagoshima University Faculty of Medicine, Kagoshima, Japan
Clin Cancer Res 10:8413-20. 2004..The aim of this study was to evaluate the expression of vascular endothelial growth factor (VEGF)-C and -D in pancreatic cancer and to reveal its relation to lymph node metastasis... - The antimetastatic role of thrombomodulin expression in islet cell-derived tumors and its diagnostic valueSatoshi Iino
Department of Surgical Oncology, Kagoshima University Graduate School of Medicine and Dental Science, Kagoshima, Japan
Clin Cancer Res 10:6179-88. 2004..In addition, thrombomodulin is a clinically useful molecular marker not only for identifying beta-cell-origin islet cell tumors (i.e., insulinomas) but also for predicting disease prognosis of islet cell tumors... - [Cancer at the esophagogastric junction]Shoji Natsugoe
Dept. of Surgical Oncology and Digestive Surgery, Graduate School of Medicine Sciences, Kagoshima University, Japan
Gan To Kagaku Ryoho 32:283-6. 2005..Adjustment of the Japanese rules for cancer of the esophagus and stomach is necessary, and a treatment strategy should be established for cancer at the esophagogastric junction... - Effect of nutritional state on postoperative axillary leakage after axillary lymph node dissection in a new rat modelYuko Kijima
Department of Surgical Oncology, Breast and Endocrine Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan
Surg Today 35:295-9. 2005..CONCLUSIONS: This model is useful for reproducing lymphatic leakage after ALD. Our findings also suggest that a low-fat diet may be advantageous for patients undergoing ALD as part of breast cancer surgery... - Intraoperative molecular detection of circulating tumor cells by reverse transcription-polymerase chain reaction in patients with biliary-pancreatic cancer is associated with hematogenous metastasisKeiichiro Uchikura
First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
Ann Surg Oncol 9:364-70. 2002.... - Roxithromycin inhibits angiogenesis of human hepatoma cells in vivo by suppressing VEGF productionDai Aoki
Department of Surgical Oncology and Digestive Surgery, Kagoshima University, School of Medicine, Kagoshima, Japan
Anticancer Res 25:133-8. 2005..Because RXM is widely used in clinical practice, it may represent an effective new strategy for human hepatoma therapy... - Early experience of immediate reconstruction using autologous free dermal fat graft after breast conservational surgeryYuko Kijima
Department of Surgical Oncology, Breast and Endocrine Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
J Plast Reconstr Aesthet Surg 60:495-502. 2007..This report documents our early experiences with seven patients who underwent BCT and immediate breast reconstruction using autologous FDFG... - A case of amyotrophic lateral sclerosis and breast cancerYuko Kijima
Department of Surgical Oncology, Breast and Endocrine Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1, Sakuragaoka, Kagoshima 890 8520, Japan
Breast Cancer 12:57-9. 2005..To the best of our knowledge, this is the first case of breast cancer occurring in a patient with ALS in Japan... - Ultrasound examination is useful for prediction of histologic type in invasive ductal carcinoma of the breastYuko Kijima
Department of Surgical Oncology, Breast and Endocrine Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
Ultrasound Med Biol 34:517-24. 2008..It is important to preoperatively estimate the histologic type by tumor property using US. Our US classifications may be useful to pick up high-risk patients for nodal metastasis in invasive breast cancer... - Successfully treated metachronous liver metastasis of alpha-fetoprotein-producing early gastric cancer: case reportSatoshi Akune
First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
Hepatogastroenterology 51:919-20. 2004..The assessment of serum alpha-fetoprotein level may be useful for detecting and monitoring liver metastasis in gastric cancer, especially for alpha-fetoprotein-producing tumors... - Clinical merit of subdividing gastric cancer according to invasion of the muscularis propriaSumiya Ishigami
First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan
Hepatogastroenterology 51:869-71. 2004..However, some mp gastric cancer patients have a good postoperative course, similar to that of early gastric cancer patients. We performed a retrospective analysis of 74 patients with mp gastric cancer, based on the depth of mp invasion... - Immediate reconstruction using inframammary adipofascial flap of the anterior rectus sheath after partial mastectomyYuko Kijima
Department of Surgical Oncology, Breast and Endocrine Surgery, Kagoshima University Graduate School of Medical and Dental Sciences 8 35 1, Sakuragaoka, Kagoshima 890 8520, Japan
Am J Surg 193:789-91. 2007..A tongue shaped flap composed of the subcutaneous fat and the anterior sheath of rectus abdominis muscle is pulled up and a C-shaped flap is rotated, gathered, and inserted to reconstruct the breast defect... - Anterior chest wall approach for video-assisted thyroidectomy using a modified neck skin lifting methodShizuo Nakano
The First Department of Surgery, Faculty of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima City, 890 8520, Japan
Biomed Pharmacother 56:96s-99s. 2002..Video-assisted thyroidectomy utilizing an anterior chest wall approach is cosmetically less invasive, particularly for women who are frequently nervous about operative scars on the neck... - Amplification and overexpression of c-met gene in Epstein-Barr virus-associated gastric carcinomasYuko Kijima
First Department of Surgery, Center for Chronic Viral Diseases, Kagoshima University, Kagoshima, Japan
Oncology 62:60-5. 2002..These results suggest that the amplification and overexpression of c-met gene do not play a different role in the progression and metastasis of EBV-positive and EBV-negative gastric carcinomas... - Sudden hemorrhage without skin invasion in a patient with breast cancer: a case report and literature reviewYuko Kijima
Department of Surgical Oncology, Breast and Endocrine Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
Breast Cancer 13:317-21. 2006..We review the literature and discuss the clinical characteristics of this unusual phenomenon... - Gene expression profiling of lymph node metastasis by oligomicroarray analysis using laser microdissection in esophageal squamous cell carcinomaYasuto Uchikado
Department of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University, Kagoshima 890-8520, Japan
Int J Oncol 29:1337-47. 2006..Although we were able to extract some genes related to nodal metastasis in ESCC, further examination is necessary in other genes as well as the interaction of stromal tissues... - Distribution of p53 mutations in esophageal and gastric carcinomas and the relationship with p53 expressionKoichi Hanazono
Department of Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, Kagoshima 890 8520, Japan
Oncol Rep 15:821-4. 2006.... - Adenoma of the nipple: report of a caseYuko Kijima
Department of Surgical Oncology, Breast and Endocrine Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1, Sakuragaoka, Kagoshima, 890 8520, Japan
Breast Cancer 13:95-9. 2006..The histological diagnosis was adenoma of the nipple. The patient was left with a cosmetically well-preserved nipple. No recurrent tumor has been observed for two years after surgery... - HLA-G expression in gastric cancerSumiya Ishigami
Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan
Anticancer Res 26:2467-72. 2006..Ectopic HLA-G expression in tumor cells may indicate immune escape from the host immune defense via the inhibitory receptor on natural killer (NK) cells. However, there is little information on HLA-G expression in gastric cancer... - Ductal carcinoma in-situ of the breast detected by [F-18] fluorodeoxyglucose positron emission tomographyTetsuhiro Owaki
Department of Surgical Oncology, Graduate School of Kagoshima University, Kagoshima City, Japan
Breast Cancer 13:210-3. 2006..We reported this rare case of ductal carcinoma in-situ detected by FDG-PET as past of a medical checkup... - Endoscopic transgastric drainage of pancreatic pseudocyst with the use of Nd:YAG laserHiroyuki Shinchi
Department of Surgical Oncology and Digestive Surgery, Kagoshima University Graduate School of Medical Sciences, Kagoshima, Japan
Surg Laparosc Endosc Percutan Tech 15:351-4. 2005..Furthermore, the Nd:YAG laser facilitated passage through a markedly indurated pseudocyst wall and it seemed to be an effective instrument, especially for pseudocysts with a thick wall... - A case of breast carcinoma with cartilaginous and osseous metaplasiaYuko Kijima
Department of Surgical Oncology, Breast and Endocrine Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Japan
Breast Cancer 13:214-9. 2006..Five months after the operation, she developed lung metastases. Although she received systemic chemotherapy, the lesions increased in number and grew rapidly. She died of pulmonary distress 5 months after relapse... - Stromal sarcoma with features of giant cell malignant fibrous histiocytomaYuko Kijima
Department of Surgical Oncology, Breast and Endocrine Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
Breast Cancer 14:239-44. 2007..To our knowledge, only 30 cases of primary MFH of the breast have been reported in the literature... - [Combination chemotherapy study of biweekly paclitaxel and S-1 administration in patients with advanced gastric cancer]Shuichi Hokita
Dept of Surgery, Imamura Hospital, Japan
Gan To Kagaku Ryoho 33:95-8. 2006..This combined therapy represents a novel and active treatment regimen with low toxicity and can be defined as safe and effective. Now we are analyzing the result of the phase II study... - The histone deacetylase inhibitor FK228 preferentially enhances adenovirus transgene expression in malignant cellsMerrill E Goldsmith
Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Clin Cancer Res 9:5394-401. 2003.... - [A case of advanced type 4 gastric cancer with peritonitis dissemination, navel metastasis effectively treated with combined chemotherapy of biweekly paclitaxel (TXL) and TS-1]Shuichi Hokita
First Dept. of Surgery, School of Medicine, Kagoshima University
Gan To Kagaku Ryoho 30:1343-6. 2003..There was no findings of recurrence 5 months later. Biweekly TXL and TS-1 therapy was thought to be an effective chemotherapy against advanced gastric cancer... - Down-regulation of Gadd45 expression is associated with tumor differentiation in non-small cell lung cancerHiroshi Higashi
Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
Anticancer Res 26:2143-7. 2006..The purpose of this study was to determine the gene expression patterns and clinical relevance of Gadd45 in tumor specimens of non-small cell lung cancer (NSCLC) patients... - [A resected case of effective treatment with gemcitabine for advanced pancreatic cancer with peritoneal metastasis]Hiroyuki Shinchi
Dept of Surgical Oncology and Digestive Surgery, Kagoshima University
Gan To Kagaku Ryoho 34:773-6. 2007..Surgical resection following chemotherapy should be performed carefully after close evaluation of the antitumor efficacy including residual isolated tumor cell for patients with previously distant metastases... - [A case of advanced rectal carcinoma, preoperative chemo-radiation therapy leading to histological complete response]Sumiya Ishigami
Surgical Dept. of Saiseikai Sendai Hospital
Gan To Kagaku Ryoho 33:1345-8. 2006..Once complete regression of the rectal cancer by chemo-radiation therapy has been achieved, relapse of the tumor was reported to be rare. Preoperative chemo-radiation therapy is an effective tool to control the advanced rectal cancer... - [Clinical efficacy of biweekly paclitaxel and S-1 regimen for 14 gastric cancer patients with liver metastases]Sumiya Ishigami
Surgical Oncology, Digestive Surgery, Kagoshima University School of Medicine
Gan To Kagaku Ryoho 34:569-72. 2007..Histological exploration revealed disappearance of liver metastases. In conclusion, biweekly paclitaxel+S-1 regimen was one of the promising therapies for advanced gastric cancer patients with liver metastases... - [Radiation therapy leading to complete response of residual lymph node metastasis in advanced gastric cancer.]Sumiya Ishigami
Dept. of Surgical Oncology, Digestive Surgery, Graduate School of Medicine, Kagoshima University
Gan To Kagaku Ryoho 32:2105-7. 2005..Therefore, our case suggests that postoperative radiation therapy can be a useful tool for treatment of residual lymph node metastasis in gastric cancer... - [A case of successful treatment by low-dose 5-fluorouracil and cisplatin for liver metastases of esophageal adenosquamous carcinoma]Yasuto Uchikado
Dept. of Surgical Oncology, Graduate School of Medicine, Kagoshima University
Gan To Kagaku Ryoho 33:83-5. 2006..After 6 courses of chemotherapy, no liver metastases were detected. Based on the present findings, we recommend low-dose 5-fluorouracil/cisplatin therapy for liver metastasis from esophageal adenosquamous carcinoma... - [An effective treatment by chemoradiation therapy after stent insertion for advanced esophageal cancer with esophago-pulmonary fistula--report of a case]Koichi Hanazono
Dept of Surgical Oncology and Digestive Surgery of Kagoshima University
Gan To Kagaku Ryoho 34:1275-8. 2007..The CRT after insertion of self-expanding metallic stent is one of the useful and palliative treatments for advance esophageal cancer with esophago-pulmonary fistula... - A randomized multicenter trial comparing resection and radiochemotherapy for resectable locally invasive pancreatic cancerMasayuki Imamura
Department of Surgery and Surgical Basic Science, Kyoto University, Kyoto 606-8507, Japan
Surgery 136:1003-11. 2004..CONCLUSIONS: Locally invasive pancreatic cancer without distant metastases and major arterial invasion appears to be best treated by surgical resection... - [A case of gemcitabine-based chemo-radiation therapy for locally advanced unresectable pancreatic cancer]Hiroyuki Shinchi
Dept. of Surgical Oncology and Hepato-Biliary-Pancreatic Surgery, Kagoshima University Graduate School of Medical and Dental Sciences
Gan To Kagaku Ryoho 33:1653-6. 2006..He died of peritoneal dissemination 43 months after diagnosis. Gemcitabine-based chemo-radiation seems to be a safe and effective regimen for unresectable pancreatic cancer... - [Lymph nodes mapping for detection of sentinel nodes in patients with papillary thyroid cancer]Shizuo Nakano
Department of Surgical Oncology and Endocrine Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-0075, Japan
Gan To Kagaku Ryoho 31:801-4. 2004..Our preliminary study indicated that sentinel lymph node biopsy was feasible in patients with thyroid cancer. It may be helpful in avoiding unnecessary lymph node dissection and improving quality of life in patients with thyroid cancer... - [A case of effective multidisciplinary treatment with hepatic resection for synchronous multiple liver metastases from rectal cancer]Yusei Haraguchi
Dept. of Surgery, Kanoya Medical Center, Citizens' Health Plaza
Gan To Kagaku Ryoho 33:1473-5. 2006..He has survived more than 6 years after the initial surgery. Multidisciplinary treatment with hepatic resection may well be a strategy for patients with multiple colorectal liver cancer, even though H 3 type of metastasis... - Chemosensitivity prediction in esophageal squamous cell carcinoma: novel marker genes and efficacy-prediction formulae using their expression dataTatsushi Shimokuni
Department of Translational Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan
Int J Oncol 28:1153-62. 2006..Our selected genes are likely to be effective drug-sensitivity markers and formulae using the 9 novel genes would provide advantages in prediction...