Akira Nishiyama

Summary

Affiliation: Kagawa Medical University
Country: Japan

Publications

  1. pmc Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats: possible involvement of N-type calcium channel in podocyte
    Yu Yan Fan
    Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Miki, Kagawa, Japan
    J Hypertens 28:1034-43. 2010
  2. ncbi request reprint [Mechanisms responsible for the renoprotective effects of renin-angiotensin inhibitors]
    Akira Nishiyama
    Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
    Yakugaku Zasshi 132:455-9. 2012
  3. ncbi request reprint RAS inhibition attenuates cognitive impairment by reducing blood- brain barrier permeability in hypertensive subjects
    Nicolas Pelisch
    Department of Pharmacology, Kagawa University Medical School, Kagawa 761 0793, Japan
    Curr Hypertens Rev 9:93-8. 2013
  4. ncbi request reprint [Mineralocorticoid receptor blocker]
    Akira Nishiyama
    Nihon Yakurigaku Zasshi 132:244-6. 2008
  5. ncbi request reprint Aldosterone and renal injury
    Akira Nishiyama
    Department of Pharmacology, Kagawa Medical University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Nihon Yakurigaku Zasshi 124:101-9. 2004
  6. ncbi request reprint New approaches to blockade of the renin-angiotensin-aldosterone system: mineralocorticoid-receptor blockers exert antihypertensive and renoprotective effects independently of the renin-angiotensin system
    Akira Nishiyama
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Kita gun, Japan
    J Pharmacol Sci 113:310-4. 2010
  7. ncbi request reprint Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferation and deformability
    Akira Nishiyama
    Department of Pharmacology, Kagawa Medical University 1750 1 Ikenobe, Miki cho, Kita gun Kagawa 761 0793, Japan
    Hypertension 45:710-6. 2005
  8. ncbi request reprint Role of interstitial ATP and adenosine in the regulation of renal hemodynamics and microvascular function
    Akira Nishiyama
    Department of Pharmacology, Kagawa Medical University, Kita gun, Japan
    Hypertens Res 27:791-804. 2004
  9. ncbi request reprint New approaches to blockade of the renin-angiotensin-aldosterone system: overview of regulation of the renin-angiotensin-aldosterone system
    Akira Nishiyama
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Japan
    J Pharmacol Sci 113:289-91. 2010
  10. ncbi request reprint Renal interstitial fluid ATP responses to arterial pressure and tubuloglomerular feedback activation during calcium channel blockade
    Akira Nishiyama
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Am J Physiol Heart Circ Physiol 290:H772-7. 2006

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. pmc Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats: possible involvement of N-type calcium channel in podocyte
    Yu Yan Fan
    Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Miki, Kagawa, Japan
    J Hypertens 28:1034-43. 2010
    ..In the present study, we examined the effects of cilnidipine and amlodipine on the renal injury in spontaneously hypertensive rat/ND mcr-cp (SHR/ND) and their underlying mechanism...
  2. ncbi request reprint [Mechanisms responsible for the renoprotective effects of renin-angiotensin inhibitors]
    Akira Nishiyama
    Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
    Yakugaku Zasshi 132:455-9. 2012
    ..We will also discuss the impact of RAS inhibitors in preventing the progressive increases in the intrarenal RAS during the development of CKD...
  3. ncbi request reprint RAS inhibition attenuates cognitive impairment by reducing blood- brain barrier permeability in hypertensive subjects
    Nicolas Pelisch
    Department of Pharmacology, Kagawa University Medical School, Kagawa 761 0793, Japan
    Curr Hypertens Rev 9:93-8. 2013
    ..These data support the hypothesis that RAS inhibition attenuates cognitive impairment by reducing BBB injury, which is independent of blood pressure changes. ..
  4. ncbi request reprint [Mineralocorticoid receptor blocker]
    Akira Nishiyama
    Nihon Yakurigaku Zasshi 132:244-6. 2008
  5. ncbi request reprint Aldosterone and renal injury
    Akira Nishiyama
    Department of Pharmacology, Kagawa Medical University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Nihon Yakurigaku Zasshi 124:101-9. 2004
    ..Aldosterone (100 nM) application activates MAPK and causes cellular proliferation and deformation. These data suggest that aldosterone contributes to the progression of glomerular injury through its direct actions...
  6. ncbi request reprint New approaches to blockade of the renin-angiotensin-aldosterone system: mineralocorticoid-receptor blockers exert antihypertensive and renoprotective effects independently of the renin-angiotensin system
    Akira Nishiyama
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Kita gun, Japan
    J Pharmacol Sci 113:310-4. 2010
    ..These data suggest that MR blockers provide a potential therapeutic approach for patients with hypertension and renal impairment who are being treated with RAS inhibitors...
  7. ncbi request reprint Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferation and deformability
    Akira Nishiyama
    Department of Pharmacology, Kagawa Medical University 1750 1 Ikenobe, Miki cho, Kita gun Kagawa 761 0793, Japan
    Hypertension 45:710-6. 2005
    ..The results indicate that aldosterone directly induces RMC proliferation and deformability through MR and ERK1/2 activation, which may contribute to the pathogenesis of glomerular mesangial injury...
  8. ncbi request reprint Role of interstitial ATP and adenosine in the regulation of renal hemodynamics and microvascular function
    Akira Nishiyama
    Department of Pharmacology, Kagawa Medical University, Kita gun, Japan
    Hypertens Res 27:791-804. 2004
    ..In this review, we also summarize current knowledge pertaining to the alterations in renal interstitial ATP and adenosine in some pathophysiological conditions...
  9. ncbi request reprint New approaches to blockade of the renin-angiotensin-aldosterone system: overview of regulation of the renin-angiotensin-aldosterone system
    Akira Nishiyama
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Japan
    J Pharmacol Sci 113:289-91. 2010
    ..Before going into details about the insights into RAAS inhibition that each of the four groups will provide, we herein briefly overview our current understanding of regulation of the circulating RAAS...
  10. ncbi request reprint Renal interstitial fluid ATP responses to arterial pressure and tubuloglomerular feedback activation during calcium channel blockade
    Akira Nishiyama
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Am J Physiol Heart Circ Physiol 290:H772-7. 2006
    ..The data provide further support to the hypothesis that RIF ATP contributes to adjustments in RVR associated with renal autoregulation and changes in activity of the TGF mechanism...
  11. ncbi request reprint Molecular mechanisms and therapeutic strategies of chronic renal injury: renoprotective effects of aldosterone blockade
    Akira Nishiyama
    Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
    J Pharmacol Sci 100:9-16. 2006
    ..In this review, we summarized our recent findings pertaining to the roles of aldosterone and MRs in the pathogenesis of renal injury. Potential molecular mechanisms responsible for aldosterone/MR-induced renal injury were also discussed...
  12. pmc Urinary angiotensinogen reflects the activity of intrarenal renin-angiotensin system in patients with IgA nephropathy
    Akira Nishiyama
    Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
    Nephrol Dial Transplant 26:170-7. 2011
    ..The present study was performed to test the hypothesis that urinary angiotensinogen provides a specific index of intrarenal RAS status in patients with immunoglobulin A (IgA) nephropathy...
  13. ncbi request reprint [Role of aldosterone in oxidative stress and renal injury]
    Akira Nishiyama
    Department of Pharmacology, Kagawa University, Kita gun, Kagawa, Japan
    Yakugaku Zasshi 127:1331-7. 2007
    ..These accumulating data support the notion that the aldosterone/MR is involved in the pathogenesis of cardiovascular and renal injuries through NADPH oxidase-dependent ROS production...
  14. pmc Strict angiotensin blockade prevents the augmentation of intrarenal angiotensin II and podocyte abnormalities in type 2 diabetic rats with microalbuminuria
    Akira Nishiyama
    Department of Pharmacology, Kagawa University Medical School, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa, Japan
    J Hypertens 26:1849-59. 2008
    ....
  15. ncbi request reprint Drug discovery for overcoming chronic kidney disease (CKD): pharmacological effects of mineralocorticoid-receptor blockers
    Akira Nishiyama
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    J Pharmacol Sci 109:1-6. 2009
    ..These data suggest that treatment with MR blockers may possibly present an effective therapeutic strategy for patients with CKD...
  16. ncbi request reprint Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats
    Akira Nishiyama
    Department of Pharmacology, Kagawa Medical University, Kagawa, Japan
    Hypertension 43:841-8. 2004
    ..Furthermore, eplerenone and tempol treatments normalized the activities of ERK1/2, JNK, and BMK1. These data suggest that ROS and MAPK play a role in the progression of renal injury induced by chronic elevations in aldosterone...
  17. pmc Effects of AT1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats
    Akira Nishiyama
    Department of Pharmacology, Research Equipment Center, Kagawa Medical University, Kagawa, Japan
    Kidney Int 65:972-81. 2004
    ..Here, we examined the effect of angiotensin II type 1 receptor (AT1) receptor blockade on renal injury and MAPK activity in Dahl salt-sensitive (DS) rats...
  18. ncbi request reprint Angiotensin II type 1 receptor-mediated augmentation of renal interstitial fluid angiotensin II in angiotensin II-induced hypertension
    Akira Nishiyama
    Department of Pharmacology, Kagawa Medical University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    J Hypertens 21:1897-903. 2003
    ..Angiotensin II (Ang II)-dependent hypertension is associated with augmented intrarenal concentrations of Ang II; however, the distribution of the increased intrarenal Ang II has not been fully established...
  19. pmc Role of angiotensin II and reactive oxygen species in cyclosporine A-dependent hypertension
    Akira Nishiyama
    Department of Pharmacology, Kagawa Medical University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Hypertension 42:754-60. 2003
    ..These data suggest that ROS generation induced by augmented Ang II levels contributes to the development of CysA-induced hypertension...
  20. ncbi request reprint Renal interstitial fluid angiotensin I and angiotensin II concentrations during local angiotensin-converting enzyme inhibition
    Akira Nishiyama
    Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana, USA
    J Am Soc Nephrol 13:2207-12. 2002
    ....
  21. ncbi request reprint The SOD mimetic tempol ameliorates glomerular injury and reduces mitogen-activated protein kinase activity in Dahl salt-sensitive rats
    Akira Nishiyama
    Department of Pharmacology, Kagawa Medical University, Kagawa, Japan
    J Am Soc Nephrol 15:306-15. 2004
    ..These data suggest that reactive oxygen species, generated by NAD(P)H oxidase, contribute to the progression of renal injury through ERK1/ERK2 activation in DS/H hypertensive rats...
  22. pmc Mineralocorticoid receptor blockade enhances the antiproteinuric effect of an angiotensin II blocker through inhibiting podocyte injury in type 2 diabetic rats
    Akira Nishiyama
    Department of Pharmacology, Kagawa University Medical School, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    J Pharmacol Exp Ther 332:1072-80. 2010
    ..o.) decreased SBP but did not alter any renal parameters. These data indicate that MR blockade enhances the SBP-independent antiproteinuric effect of an ARB through inhibiting podocyte injury in type 2 diabetic rats...
  23. ncbi request reprint Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases
    Guo Xing Zhang
    Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
    Am J Physiol Heart Circ Physiol 293:H2403-8. 2007
    ....
  24. pmc Temporary angiotensin II blockade at the prediabetic stage attenuates the development of renal injury in type 2 diabetic rats
    Yukiko Nagai
    Department of Pharmacology, Kagawa Medical University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    J Am Soc Nephrol 16:703-11. 2005
    ..These data suggest that early AngII blockade could be an effective strategy for preventing the development of type 2 diabetic renal injury later in life...
  25. doi request reprint Mineralocorticoid receptor blockade and calcium channel blockade have different renoprotective effects on glomerular and interstitial injury in rats
    Jun Du
    Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
    Am J Physiol Renal Physiol 297:F802-8. 2009
    ..The combination of eplerenone and amlodipine improved renal injury more effectively than either monotherapy in high salt-fed DS rats, presumably by achieving their own renoprotective effects...
  26. doi request reprint Inhibitory effects of a dihydropyridine calcium channel blocker on renal injury in aldosterone-infused rats
    Yu Yan Fan
    Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University, Japan
    J Hypertens 27:1855-62. 2009
    ..The present study was conducted to examine the effects of a dihydropyridine calcium channel blocker, azelnidipine, on aldosterone-induced oxidative stress and renal injury...
  27. ncbi request reprint Augmentation of intrarenal angiotensin II levels in uninephrectomized aldosterone/salt-treated hypertensive rats; renoprotective effects of an ultrahigh dose of olmesartan
    Yu Yan Fan
    Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
    Hypertens Res 29:169-78. 2006
    ..These data suggest that augmented local Ang II activity contributes, at least partially, to the progression of aldosterone/salt-dependent renal injury...
  28. ncbi request reprint D-allose, an all-cis aldo-hexose, suppresses development of salt-induced hypertension in Dahl rats
    Shoji Kimura
    Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
    J Hypertens 23:1887-94. 2005
    ....
  29. ncbi request reprint Role of AT1 receptor in isoproterenol-induced cardiac hypertrophy and oxidative stress in mice
    Guo Xing Zhang
    Department of Pharmacology, Kagawa University Medical School, 1750 1 Ikenobe, Miki, Kagawa 761 0793, Japan
    J Mol Cell Cardiol 42:804-11. 2007
    ....
  30. ncbi request reprint Time-dependent transition of tempol-sensitive reduction of blood pressure in angiotensin II-induced hypertension
    Shoji Kimura
    Department of Pharmacology, Research Equipment Center and Radioisotope Research Center, Kagawa University Medical School, Kagawa, Japan
    J Hypertens 22:2161-8. 2004
    ..We examined the time-dependent transition of ROS-sensitive vasoconstriction during angiotensin II infusion and also ROS sensitivity to cardiovascular MAPK activation in acutely and chronically angiotensin II-infused rats...
  31. pmc Aldosterone does not contribute to renal p21 expression during the development of angiotensin II-induced hypertension in mice
    Daisuke Nakano
    Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
    Am J Hypertens 25:354-8. 2012
    ..In the present study, we investigated the contribution of aldosterone to the renal p21 expression and senescence during the development of angiotensin II (AngII)-induced hypertension...
  32. ncbi request reprint Effects of adrenomedullin on cardiac oxidative stress and collagen accumulation in aldosterone-dependent malignant hypertensive rats
    Matlubur Rahman
    Department of Pharmacology, Kagawa University Medical School, Kitagun, Kagawa 761 0793, Japan
    J Pharmacol Exp Ther 318:1323-9. 2006
    ....
  33. ncbi request reprint Contribution of reactive oxygen species to the pathogenesis of left ventricular failure in Dahl salt-sensitive hypertensive rats: effects of angiotensin II blockade
    Peng Guo
    Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University Medical School, Kita gun, Kagawa, Japan
    J Hypertens 24:1097-104. 2006
    ....
  34. pmc Olmesartan improves endothelin-induced hypertension and oxidative stress in rats
    Li Yao
    Department of Pharmacology, Kagawa Medical University, Japan
    Hypertens Res 27:493-500. 2004
    ..The combined effects of the elevations in circulating ET-1 and Ang II, as well as the associated ROS production, may contribute to the development of hypertension induced by chronic ET-1 infusion...
  35. ncbi request reprint Role of NAD(P)H oxidase- and mitochondria-derived reactive oxygen species in cardioprotection of ischemic reperfusion injury by angiotensin II
    Shoji Kimura
    Department of Pharmacology, Kagawa University Medical School, Miki, Kagawa, Japan
    Hypertension 45:860-6. 2005
    ..These results suggest that the preconditioning effects of Ang II for cardiac I/R injury may be mediated by cardiac mitochondria-derived ROS enhanced through NAD(P)H oxidase via JNK and p38 mitogen-activated protein kinase activation...
  36. pmc Add-on aliskiren elicits stronger renoprotection than high-dose valsartan in type 2 diabetic KKAy mice that do not respond to low-dose valsartan
    Bai Lei
    Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
    J Pharmacol Sci 119:131-8. 2012
    ..In conclusion, the anti-albuminuric effect that was observed in the type 2 diabetic mice showing no anti-albuminuric effect by valsartan can be attributed to the add-on aliskiren...
  37. ncbi request reprint Mitochondria-derived reactive oxygen species and vascular MAP kinases: comparison of angiotensin II and diazoxide
    Shoji Kimura
    Department of Pharmacology, Kagawa University Medical School, 1750 1 Ikenobe, Miki, Kagawa 761 0793, Japan
    Hypertension 45:438-44. 2005
    ....
  38. ncbi request reprint Aldosterone stimulates collagen gene expression and synthesis via activation of ERK1/2 in rat renal fibroblasts
    Yukiko Nagai
    Research Equipment Center, Kagawa Medical University, Kagawa, Japan
    Hypertension 46:1039-45. 2005
    ..These results suggest that aldosterone stimulates collagen gene expression and synthesis via MR-mediated ERK1/2 activation in renal fibroblasts, which may contribute to the progression of aldosterone-induced tubulointerstitial fibrosis...
  39. ncbi request reprint Effects of a new calcium channel blocker, azelnidipine, on systemic hemodynamics and renal sympathetic nerve activity in spontaneously hypertensive rats
    Takatomi Shokoji
    Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
    Hypertens Res 28:1017-23. 2005
    ..05). These data suggest that azelnidipine possesses sympathoinhibitory effects, which may be one reason why it had less pronounced effects on HR in hypertensive patients...
  40. pmc Oxidative stress-induced glomerular mineralocorticoid receptor activation limits the benefit of salt reduction in Dahl salt-sensitive rats
    Kento Kitada
    Department of Pharmacology, Kagawa University, Kagawa, Japan
    PLoS ONE 7:e41896. 2012
    ..Furthermore, we determined if MR activation persisted and induced renal injury, even after switching from a high- to a normal-salt diet...
  41. pmc Systemic candesartan reduces brain angiotensin II via downregulation of brain renin-angiotensin system
    Nicolas Pelisch
    Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University Medical School, Kagawa, Japan
    Hypertens Res 33:161-4. 2010
    ..These data suggest that treatment with candesartan decreases brain angiotensin II by decreasing brain angiotensinogen and angiotensin converting enzyme gene expression...
  42. doi request reprint Angiotensin II induces human astrocyte senescence through reactive oxygen species production
    Gang Liu
    Department of Pharmacology, Kagawa University School of Medicine, Kagawa, Japan
    Hypertens Res 34:479-83. 2011
    ..Moreover, Ang II significantly upregulated p16 mRNA expression, which was inhibited by pretreatment with CV11974 or tempol. These findings indicate that superoxide production contributes to Ang II-induced astrocyte senescence...
  43. ncbi request reprint ROS during the acute phase of Ang II hypertension participates in cardiovascular MAPK activation but not vasoconstriction
    Guo Xing Zhang
    Department of Pharmacology, Kagawa University Medical School, 1750 1 Miki cho, Kagawa 761 0793, Japan
    Hypertension 43:117-24. 2004
    ....
  44. doi request reprint Aldosterone induces vascular insulin resistance by increasing insulin-like growth factor-1 receptor and hybrid receptor
    Shamshad J Sherajee
    Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Arterioscler Thromb Vasc Biol 32:257-63. 2012
    ....
  45. ncbi request reprint Cardiac oxidative stress in acute and chronic isoproterenol-infused rats
    Guo Xing Zhang
    Department of Pharmacology, Kagawa University Medical School, 1750 1 Ikenobe, Miki, Kagawa 761 0793, Japan
    Cardiovasc Res 65:230-8. 2005
    ..This study aimed to clarify the role of reactive oxygen species (ROS) in mitogen-activated protein (MAP) kinase activation and tissue remodeling of the heart of isoproterenol (ISO)-infused rats...
  46. ncbi request reprint Effects of local administrations of tempol and diethyldithio-carbamic on peripheral nerve activity
    Takatomi Shokoji
    Department of Pharmacology, Kagawa Medical University, Kita gun, Kagawa, Japan
    Hypertension 44:236-43. 2004
    ..These results suggest that reactive oxygen species play a role in the regulation of peripheral sympathetic nerve activity, and that at least part of this mechanism is mediated through voltage-gated potassium channels...
  47. pmc Contribution of chymase-dependent angiotensin II formation to the progression of tubulointerstitial fibrosis in obstructed kidneys in hamsters
    Yu Yan Fan
    Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University Medical School, Japan
    J Pharmacol Sci 111:82-90. 2009
    ..These data suggest that chymase-dependent intrarenal AngII formation contributes to the pathogenesis of interstitial fibrosis in obstructed kidneys of hamsters...
  48. pmc Angiotensin-converting enzyme inhibitor does not suppress renal angiotensin II levels in angiotensin I-infused rats
    Keisuke Ohnishi
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    J Pharmacol Sci 122:103-8. 2013
    ....
  49. doi request reprint Neuroprotective effects of angiotensin II type 1 receptor (AT1-R) blocker via modulating AT1-R signaling and decreased extracellular glutamate levels
    Tomoyoshi Fujita
    Department of Ophthalmology, Kagawa University, Kagawa, Japan
    Invest Ophthalmol Vis Sci 53:4099-110. 2012
    ..To investigate the mechanism of the neuroprotective effects of the angiotensin II type 1 receptor (AT1-R) blocker against retinal ischemia-reperfusion injury in the rat...
  50. pmc Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats
    Tadashi Sofue
    Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Am J Hypertens 25:604-11. 2012
    ....
  51. doi request reprint Roles of central renin-angiotensin system and afferent renal nerve in the control of systemic hemodynamics in rats
    Yoshihide Fujisawa
    Life Science Research Center, Faculty of Medicine, Kagawa University, Ikenobe, Miki cho, Kita gun, Japan
    Hypertens Res 34:1228-32. 2011
    ..These results indicate that signals transmitted by ARNs have an important role in the control of systemic hemodynamics through regulating central RAS-mediated changes in sympathetic nerve activity...
  52. ncbi request reprint Effects of angiotensin II on the renal interstitial concentrations of NO2/NO3 and cyclic GMP in anesthetized rats
    Matlubur Rahman
    Department of Pharmacology, Kagawa Medical University, Japan
    Jpn J Pharmacol 88:436-41. 2002
    ..These results suggest that Ang II stimulates NO production via the AT2-receptor in the kidney...
  53. ncbi request reprint DOI, a 5-HT2 receptor agonist, induces renal vasodilation via nitric oxide in anesthetized dogs
    Run Xian Tian
    Department of Pharmacology, Kagawa Medical University, 1750 1 Ikenobe, Miki cho, Kita gun, 761 0793, Kagawa, Japan
    Eur J Pharmacol 437:79-84. 2002
    ..These results suggest that DOI caused renal vasodilation due to increased NO release/production by stimulation of 5-HT2 receptors in the kidney. The natriuretic effect of DOI might also be related to increased intrarenal NO production...
  54. ncbi request reprint Renal sympathetic nerve responses to tempol in spontaneously hypertensive rats
    Takatomi Shokoji
    Second Department of Medicine, Kagawa Medical University, Kita gun, Kagawa, Japan
    Hypertension 41:266-73. 2003
    ..These results suggest that augmented superoxide production contributes to the development of hypertension through activation of the sympathetic nervous system...
  55. pmc Angiotensin II shifts insulin signaling into vascular remodeling from glucose metabolism in vascular smooth muscle cells
    Hirofumi Hitomi
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Am J Hypertens 24:1149-55. 2011
    ....
  56. doi request reprint Involvement of mineralocorticoid receptor in high glucose-induced big mitogen-activated protein kinase 1 activation and mesangial cell proliferation
    Gang Liu
    Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
    J Hypertens 28:536-42. 2010
    ..The inhibitory actions of mineralocorticoid receptor antagonists may contribute to their preventive effects on diabetic nephropathy, which have been reported in recent clinical studies...
  57. doi request reprint Echocardiographic assessment of the cardio-renal connection: is left ventricular hypertrophy or diastolic function more closely correlated with estimated glomerular filtration rate in patients with cardiovascular risk factors?
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kita gun, Kagawa, Japan
    Clin Exp Hypertens 32:113-20. 2010
    ..Therefore, LV hypertrophy may be superior to LV diastolic dysfunction in predicting low eGFR in patients with CKD using echocardiography...
  58. ncbi request reprint Inhibition of nitric oxide synthase enhances superoxide activity in canine kidney
    Dewan S A Majid
    Dept of Physiology, SL 39, Tulane Univ Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Am J Physiol Regul Integr Comp Physiol 287:R27-32. 2004
    ..These data suggest that NO synthase inhibition causes enhancement of endogenous O(2)(-) levels and support the hypothesis that NO plays a protective role against the actions of O(2)(-) in the kidney...
  59. ncbi request reprint Effects of calcium channel blockade on angiotensin II-induced peritubular ischemia in rats
    Naoki Kondo
    Second Department of Internal Medicine, Kagawa University Medical School, Kagawa, Japan
    J Pharmacol Exp Ther 316:1047-52. 2006
    ..These data suggest that calcium channel blockade attenuates AngII-induced peritubular ischemia, which may be involved in its beneficial effects on renal injury...
  60. pmc Effects of mineralocorticoid receptor blockade on glucocorticoid-induced renal injury in adrenalectomized rats
    Kazi Rafiq
    Department of Pharmacology, University Health Sciences Center, Louisiana, USA
    J Hypertens 29:290-8. 2011
    ..We hypothesized that glucocorticoids are involved in the development of renal injury through an mineralocorticoid receptor-dependent mechanism...
  61. doi request reprint Possible contribution of the non-proteolytic activation of prorenin to the development of insulin resistance in fructose-fed rats
    Yukiko Nagai
    Life Sciences Research Center, Kagawa University, Miki, Kita, Kagawa 761 0793, Japan
    Exp Physiol 94:1016-23. 2009
    ..These data suggest that local angiotensin II generation in skeletal muscle, induced by non-proteolytic activation of prorenin, contributes to the development of insulin resistance induced by a high fructose diet...
  62. pmc N-type calcium channel inhibition with cilnidipine elicits glomerular podocyte protection independent of sympathetic nerve inhibition
    Bai Lei
    Department of Pharmacology, Kagawa University Medical School, Japan
    J Pharmacol Sci 119:359-67. 2012
    ..These data indicate that renal nerves have a limited contribution to the cilnidipine-induced reno-protective effects in HS-UNX-SHR...
  63. doi request reprint Therapeutic effects of postischemic treatment with hypotensive doses of an angiotensin II receptor blocker on transient focal cerebral ischemia
    Hua Fu
    Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University School of Medicine, Kagawa, Japan
    J Hypertens 29:2210-9. 2011
    ....
  64. pmc Effect of efonidipine on TGF-β1-induced cardiac fibrosis through Smad2-dependent pathway in rat cardiac fibroblasts
    Bai Lei
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Japan
    J Pharmacol Sci 117:98-105. 2011
    ..These data suggest that efonidipine elicits inhibitory effects on TGF-β1- and Smad2-dependent protein synthesis through both T-type and L-type calcium channel-blocking actions in cardiac fibroblasts...
  65. ncbi request reprint Involvements of Rho-kinase and TGF-beta pathways in aldosterone-induced renal injury
    Guang Ping Sun
    Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University Medical School, Kagawa, Japan
    J Am Soc Nephrol 17:2193-201. 2006
    ..These results provide evidence, for the first time, that Rho-kinase is substantially involved in aldosterone-induced renal injury through activation of a TGF-beta-dependent pathway...
  66. pmc Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension
    Miguel L Graciano
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, USA
    Am J Physiol Renal Physiol 294:F161-9. 2008
    ..05). The results suggest that activation of vascular and glomerular purinergic P2 receptors may contribute to the mesangial cell transformation, renal inflammation, and vascular hypertrophy observed in ANG II-dependent hypertension...
  67. pmc Blockade of AT1 receptors protects the blood-brain barrier and improves cognition in Dahl salt-sensitive hypertensive rats
    Nicolas Pelisch
    Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University Medical School, Japan
    Am J Hypertens 24:362-8. 2011
    ..Effects of an angiotensin II (AngII) type-1 receptor blocker (ARB), at a dose that did not reduce blood pressure, were also examined...
  68. doi request reprint Possible involvement of Rho-kinase in aldosterone-induced vascular smooth muscle cell remodeling
    Kayoko Miyata
    Life Sciences Research Center, Kagawa University Medical School, Kagawa, Japan
    Hypertens Res 31:1407-13. 2008
    ..These findings indicate that Rho-kinase is involved in the pathogenesis of aldosterone-induced VSMC remodeling...
  69. doi request reprint The opposite roles of nNOS in cardiac ischemia-reperfusion-induced injury and in ischemia preconditioning-induced cardioprotection in mice
    Xiao Mei Lu
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Takamatsu 761 0793, Japan
    J Physiol Sci 59:253-62. 2009
    ..In conclusion, nNOS played a dual role during cardiac IR and IP; nNOS exacerbated IR-induced injury by increasing oxidative/nitrative stress and contributed to IP-induced protection by inhibition of oxidative/nitrative stress...
  70. pmc Enhancement of intrarenal angiotensinogen in Dahl salt-sensitive rats on high salt diet
    Hiroyuki Kobori
    Department of Physiology, Tulane University Health Sciences Center, 1430 Tulane Ave, SL39, New Orleans, LA 70112 2699, USA
    Hypertension 41:592-7. 2003
    ..The results suggest that DS on HS have an inappropriate augmentation of intrarenal angiotensinogen, which may contribute to impaired sodium excretion during a high salt diet and the development of hypertension in this strain...
  71. ncbi request reprint Roles of adrenomedullin 2 in regulating the cardiovascular and sympathetic nervous systems in conscious rats
    Yoshihide Fujisawa
    Research Equipment Center, School of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Am J Physiol Heart Circ Physiol 290:H1120-7. 2006
    ..These findings indicate that the physiological roles of rAM2 and rAM are similar and that rAM2 also has a long-lasting vasodilator action on the renal vascular bed...
  72. doi request reprint Aldosterone induces myofibroblastic transdifferentiation and collagen gene expression through the Rho-kinase dependent signaling pathway in rat mesangial cells
    Suwarni Diah
    Department of Pharmacology Faculty of Medicine, Kagawa University, 761 0793, Japan
    Exp Cell Res 314:3654-62. 2008
    ..These results suggest that aldosterone-induced mesangial cell hypertrophy is associated with cell transformation, leading to an increase in collagen gene expression via the Rho-kinase dependent signaling pathway...
  73. ncbi request reprint Aldosterone stimulates reactive oxygen species production through activation of NADPH oxidase in rat mesangial cells
    Kayoko Miyata
    Department of Pharmacology, Kagawa Medical University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    J Am Soc Nephrol 16:2906-12. 2005
    ..These cellular actions of aldosterone may play a role in the pathogenesis of glomerular mesangial injury...
  74. ncbi request reprint Effects of adrenomedullin 2 on regional hemodynamics in conscious rats
    Yoshihide Fujisawa
    Life Science Center, School of Medicine, Kagawa University, 1750 1 Ikenobe, Kita gun, Kagawa, Japan
    Eur J Pharmacol 558:128-32. 2007
    ..Rat adrenomedullin 2 may contribute to the regulation of the cardiovascular system, by acting as a local vasodilatory hormone as well as a circulatory hormone...
  75. doi request reprint Aldosterone/Mineralocorticoid receptor stimulation induces cellular senescence in the kidney
    Yu Yan Fan
    Department of Cardiorenal and Cerebrovascular Medicine, Life Sciences Research Center, Kagawa University, Kagawa 761 0793, Japan
    Endocrinology 152:680-8. 2011
    ..These findings indicate that aldosterone induces renal senescence in proximal tubular cells via the MR and p21-dependent pathway, which may be involved in aldosterone-induced renal injury...
  76. ncbi request reprint Aldosterone stimulates vascular smooth muscle cell proliferation via big mitogen-activated protein kinase 1 activation
    Keisuke Ishizawa
    Department of Pharmacology, University of Tokushima Graduate School of Medicine, Japan
    Hypertension 46:1046-52. 2005
    ..In addition to the classical steroid activity, rapid nongenomic effects induced by aldosterone may represent an alternative etiology for vascular diseases such as hypertension...
  77. pmc The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease
    Hiroyuki Kobori
    Department of Medicine, Director of the Molecular Core in Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Pharmacol Rev 59:251-87. 2007
    ..We will also discuss the impact of antihypertensive agents in preventing the progressive increases in the intrarenal RAS during the development of hypertension and renal injury...
  78. doi request reprint Comparison of central blood pressure and cardio-ankle vascular index for association with cardiac function in treated hypertensive patients
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kita gun, Japan
    Hypertens Res 32:1136-42. 2009
    ..In contrast, CAVI may be suitable for detecting LV dysfunction. This difference, suggesting the clinical value of each parameter, should be kept in mind when we use CBP and CAVI for assessing arteriosclerosis in treated hypertension...
  79. ncbi request reprint Renoprotective effects of l-carnosine on ischemia/reperfusion-induced renal injury in rats
    Hayato Kurata
    Department of Pharmacology, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    J Pharmacol Exp Ther 319:640-7. 2006
    ....
  80. pmc Effects of tempol on renal angiotensinogen production in Dahl salt-sensitive rats
    Hiroyuki Kobori
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Biochem Biophys Res Commun 315:746-50. 2004
    ..The evidence suggests that the enhanced intrarenal angiotensinogen in DS challenged with HS is associated with the augmented reactive oxygen species...
  81. ncbi request reprint Renal interstitial fluid concentrations of angiotensins I and II in anesthetized rats
    Akira Nishiyama
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Hypertension 39:129-34. 2002
    ....
  82. ncbi request reprint Possible underlying mechanisms responsible for aldosterone and mineralocorticoid receptor-dependent renal injury
    Hideyasu Kiyomoto
    Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Japan
    J Pharmacol Sci 108:399-405. 2008
    ..In this review, we summarized recent findings on the roles of aldosterone and MR in the pathogenesis of renal injury with particular emphasis on potential underlying mechanisms...
  83. ncbi request reprint Nitric oxide blockade enhances renal responses to superoxide dismutase inhibition in dogs
    Dewan S A Majid
    Department of Physiology, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Hypertension 39:293-7. 2002
    ..These responses are enhanced during NO synthase blockade, suggesting that NO serves a renoprotective effect against these action of O(2)(-)...
  84. ncbi request reprint Superoxide scavenging attenuates renal responses to ANG II during nitric oxide synthase inhibition in anesthetized dogs
    Dewan S A Majid
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 288:F412-9. 2005
    ..The sodium-retaining effect of ANG II is greatly influenced by O2- generation, particularly in the condition of NO deficiency...
  85. ncbi request reprint Role of mitochondria in angiotensin II-induced reactive oxygen species and mitogen-activated protein kinase activation
    Guo Xing Zhang
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Cardiovasc Res 76:204-12. 2007
    ....
  86. pmc Regulation of intrarenal angiotensin II in hypertension
    L Gabriel Navar
    Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Hypertension 39:316-22. 2002
    ..Collectively, the data support a powerful role for intrarenal Ang II in the pathogenesis of hypertension...
  87. pmc Urinary angiotensinogen as an indicator of intrarenal Angiotensin status in hypertension
    Hiroyuki Kobori
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Hypertension 41:42-9. 2003
    ..The results support the hypothesis that AngII-dependent hypertension results in elevated intrarenal AngII and angiotensinogen levels, reflected by increased U(AGT), which does not occur in an AngII-independent hypertensive model...
  88. ncbi request reprint Blood flow-dependent changes in renal interstitial guanosine 3',5'-cyclic monophosphate in rabbits
    Akira Nishiyama
    Department of Pharmacology, Kagawa Medical University, Kagawa 761 0793, Japan
    Am J Physiol Renal Physiol 282:F238-44. 2002
    ..These results indicate that acute changes in RBF result in alterations in nitric oxide-dependent renal interstitial cGMP levels, with differential effects in the medulla compared with the cortex...
  89. ncbi request reprint Angiotensin II and oxidative stress
    Hirofumi Hitomi
    Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Curr Opin Cardiol 22:311-5. 2007
    ..The purpose of this review is to discuss the mechanism of reactive oxygen species formation and the pathophysiological effects of angiotensin II in the cardiovascular system...
  90. pmc Enhanced intrarenal angiotensinogen contributes to early renal injury in spontaneously hypertensive rats
    Hiroyuki Kobori
    Department of Physiology, Tulane University Health Sciences Center, 1430 Tulane Avenue, SL39, New Orleans, LA 70112 2699, USA
    J Am Soc Nephrol 16:2073-80. 2005
    ..These results indicate that SHR have enhanced intrarenal angiotensinogen production that contributes to increased Ang II levels leading to the development of hypertension and renal injury in this strain...
  91. ncbi request reprint [Mineralocorticoid receptor]
    Akira Nishiyama
    Department of Pharmacology, Kagawa University Medical School
    Nihon Rinsho 67:695-700. 2009
    ..These accumulating data support the notion that aldosterone is involved in the pathogenesis of cardiovascular and renal injuries through local MR activation...
  92. ncbi request reprint Angiotensin II stimulates superoxide production via both angiotensin AT1A and AT1B receptors in mouse aorta and heart
    Matlubur Rahman
    Department of Pharmacology, Kagawa Medical University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 61 0793, Japan
    Eur J Pharmacol 485:243-9. 2004
    ....
  93. ncbi request reprint Role of (pro)renin receptor in cardiovascular cells from the aspect of signaling
    Hirofumi Hitom
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Front Biosci (Elite Ed) 2:1246-9. 2010
    ..In this review, we summarize novel intracellular signaling systems and their downstream effects via (pro)renin receptors in cardiovascular and kidney cells...
  94. ncbi request reprint Renal effects of a new member of adrenomedullin family, adrenomedullin2, in rats
    Yoshihide Fujisawa
    Research Equipment Center, School of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Eur J Pharmacol 497:75-80. 2004
    ..Thus, the renal actions induced by adrenomedullin2 were similar to those of adrenomedullin. These data suggest that adrenomedullin2 may play an important role in the regulation of renal hemodynamics and urine formation...
  95. ncbi request reprint Synergistic effect of mechanical stretch and angiotensin II on superoxide production via NADPH oxidase in vascular smooth muscle cells
    Hirofumi Hitomi
    Division of Nephrology, Kagawa University Faculty of Medicine, Kita gun, Kagawa, Japan
    J Hypertens 24:1089-95. 2006
    ....
  96. ncbi request reprint Aldosterone suppresses insulin signaling via the downregulation of insulin receptor substrate-1 in vascular smooth muscle cells
    Hirofumi Hitomi
    Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Kita gun, Japan
    Hypertension 50:750-5. 2007
    ....
  97. doi request reprint The role of basic fibroblast growth factor to enhance fetal intestinal mucosal cell regeneration in vivo
    Atsushi Yoshida
    Department of Pediatric Surgery, Faculty of Medicine, Kagawa University, Miki cho, Kida gun, Kagawa, 761 0793, Japan
    Pediatr Surg Int 25:691-5. 2009
    ..The purpose of this study was to evaluate whether basic fibroblast growth factor (bFGF) could facilitate regeneration of fetal small intestinal mucosa in vivo...
  98. ncbi request reprint Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, 160 8582, Japan
    J Am Soc Nephrol 17:1950-61. 2006
    ..It is not only AngII but also intraglomerular activation of MAPK by the receptor-associated prorenin that plays a pivotal role in diabetic nephropathy...
  99. ncbi request reprint Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damage
    Atsuhiro Ichihara
    Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Am Soc Nephrol 17:2495-503. 2006
    ..These studies clearly demonstrated that nonproteolytic activation of prorenin in glomeruli is critically involved in renal tissue RAS activation, leading to renal damage in hypertensive animals...
  100. ncbi request reprint Ischemic preconditioning protects post-ischemic renal function in anesthetized dogs: role of adenosine and adenine nucleotides
    Fan Zhu Li
    Department of Pharmaceutics, Zhejiang College of Traditional Chinese Medicine, Hangzhou 310053, China
    Acta Pharmacol Sin 26:851-9. 2005
    ..To investigate the effects of renal ischemic preconditioning (IPC) on both renal hemodynamics and the renal interstitial concentrations of adenosine and adenine nucleotides induced by ischemia-reperfusion injury...
  101. ncbi request reprint Dietary sesamin suppresses aortic NADPH oxidase in DOCA salt hypertensive rats
    Daisuke Nakano
    Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
    Clin Exp Pharmacol Physiol 35:324-6. 2008
    ..4. In conclusion, dietary sesamin prevented DOCA salt-induced increases in NADPH oxidase activity and subunit mRNA expression. These effects seem to be involved in the anti-oxidant and antihypertensive effects of sesamin...