Takehiro Nakamura

Summary

Affiliation: Kagawa Medical University
Country: Japan

Publications

  1. ncbi request reprint Nestin expression after experimental intracerebral hemorrhage
    Takehiro Nakamura
    Department of Neurosurgery, University of Michigan, 5550 Kresge I, Ann Arbor, MI 48109 0532, USA
    Brain Res 981:108-17. 2003
  2. pmc The Modules for ISLS/PNLS Combined Course as International Version: Report of Workshop in 9 International Conference of Cerebrovascular Surgery
    Takehiro Nakamura
    The committee of ISLS course, Japanese Congress on Neurological Emergency
    Asian J Neurosurg 5:95-100. 2010
  3. pmc Report on the international Primary Neurosurgical Life Support course in the eighth Asian Congress of Neurological Surgeons in Kuala Lumpur, Malaysia
    Takehiro Nakamura
    The Committee of Primary Neurosurgical Life Support Course, The Japan Society of Neurosurgical Emergency, Japan
    Asian J Neurosurg 6:2-5. 2011
  4. ncbi request reprint Cerebral metabolism monitoring during hypothermia following resuscitation from cardiopulmonary arrest
    Takehiro Nakamura
    Department of Neurobiology, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki, Kita, Kagawa 761 0173, Japan
    Acta Neurochir Suppl 102:203-6. 2008
  5. ncbi request reprint Hyperbaric oxygen therapy for consciousness disturbance following head injury in subacute phase
    Takehiro Nakamura
    Department of Neurobiology, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki, Kita, Kagawa 761 0173, Japan
    Acta Neurochir Suppl 102:21-4. 2008
  6. ncbi request reprint Radial glia marker expression following experimental intracerebral hemorrhage
    T Nakamura
    Department of Neurobiology, Kagawa University Faculty of Medicine, Miki, Kagawa, Japan
    Acta Neurochir Suppl 105:95-7. 2008
  7. doi request reprint 3CB2, a marker of radial glia, expression after experimental intracerebral hemorrhage: role of thrombin
    Takehiro Nakamura
    Department of Neurobiology, Kagawa University Faculty of Medicine, Kagawa, Japan
    Brain Res 1226:156-62. 2008
  8. doi request reprint Anti-oxidative effects of d-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat
    Takehiro Nakamura
    Department of Neurobiology, Kagawa University Faculty of Medicine, Miki, Kita, Kagawa, Japan
    Neurosci Lett 487:103-6. 2011
  9. ncbi request reprint Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage
    Takehiro Nakamura
    Department of Neurobiology, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Miki, Kagawa 761 0793, Japan
    Stroke 39:463-9. 2008
  10. doi request reprint Serine protease inhibitor attenuates intracerebral hemorrhage-induced brain injury and edema formation in rat
    Takehiro Nakamura
    Department of Neurobiology and Neurological Surgery, Kagawa University Faculty of Medicine, Kita, Kagawa, Japan
    Acta Neurochir Suppl 106:307-10. 2010

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Nestin expression after experimental intracerebral hemorrhage
    Takehiro Nakamura
    Department of Neurosurgery, University of Michigan, 5550 Kresge I, Ann Arbor, MI 48109 0532, USA
    Brain Res 981:108-17. 2003
    ..Nestin induction by a low dose of thrombin suggests that specific receptor-mediated pathways are involved in inducing nestin expression and that nestin may play a role in thrombin preconditioning...
  2. pmc The Modules for ISLS/PNLS Combined Course as International Version: Report of Workshop in 9 International Conference of Cerebrovascular Surgery
    Takehiro Nakamura
    The committee of ISLS course, Japanese Congress on Neurological Emergency
    Asian J Neurosurg 5:95-100. 2010
    ..This report summarizes the modules for ISLS/PSLS combined course as international version from the workshop...
  3. pmc Report on the international Primary Neurosurgical Life Support course in the eighth Asian Congress of Neurological Surgeons in Kuala Lumpur, Malaysia
    Takehiro Nakamura
    The Committee of Primary Neurosurgical Life Support Course, The Japan Society of Neurosurgical Emergency, Japan
    Asian J Neurosurg 6:2-5. 2011
    ..This report summarizes the international version of PNLS course in 8(th) ACNS...
  4. ncbi request reprint Cerebral metabolism monitoring during hypothermia following resuscitation from cardiopulmonary arrest
    Takehiro Nakamura
    Department of Neurobiology, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki, Kita, Kagawa 761 0173, Japan
    Acta Neurochir Suppl 102:203-6. 2008
    ..The aim of the present study was to evaluate cerebral metabolism monitoring during therapeutic hypothermia for global ischemic brain damage after cardiopulmonary resuscitation (CPR)...
  5. ncbi request reprint Hyperbaric oxygen therapy for consciousness disturbance following head injury in subacute phase
    Takehiro Nakamura
    Department of Neurobiology, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki, Kita, Kagawa 761 0173, Japan
    Acta Neurochir Suppl 102:21-4. 2008
    ..The purpose of the present study was to investigate the effect of hyperbaric oxygen (HBO) therapy on the cerebral circulation and metabolism of patients with disturbances in consciousness after head injury in the subacute phase...
  6. ncbi request reprint Radial glia marker expression following experimental intracerebral hemorrhage
    T Nakamura
    Department of Neurobiology, Kagawa University Faculty of Medicine, Miki, Kagawa, Japan
    Acta Neurochir Suppl 105:95-7. 2008
    ....
  7. doi request reprint 3CB2, a marker of radial glia, expression after experimental intracerebral hemorrhage: role of thrombin
    Takehiro Nakamura
    Department of Neurobiology, Kagawa University Faculty of Medicine, Kagawa, Japan
    Brain Res 1226:156-62. 2008
    ..Thrombin has a role in 3CB2 expression in ICH...
  8. doi request reprint Anti-oxidative effects of d-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat
    Takehiro Nakamura
    Department of Neurobiology, Kagawa University Faculty of Medicine, Miki, Kita, Kagawa, Japan
    Neurosci Lett 487:103-6. 2011
    ..The number of AP-sites and 8-OHdG levels were also reduced by D-allose. Thus, the present study suggests that D-allose has anti-oxidative effects and induces neuroprotection in focal cerebral ischemia...
  9. ncbi request reprint Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage
    Takehiro Nakamura
    Department of Neurobiology, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Miki, Kagawa 761 0793, Japan
    Stroke 39:463-9. 2008
    ..Our previous studies have demonstrated that oxidative DNA injury occurs in the brain after intracerebral hemorrhage (ICH). We therefore examined whether edaravone, a free-radical scavenger, could reduce ICH-induced brain injury...
  10. doi request reprint Serine protease inhibitor attenuates intracerebral hemorrhage-induced brain injury and edema formation in rat
    Takehiro Nakamura
    Department of Neurobiology and Neurological Surgery, Kagawa University Faculty of Medicine, Kita, Kagawa, Japan
    Acta Neurochir Suppl 106:307-10. 2010
    ..FUT did not increase collagenase-induced hematoma volume. FUT attenuates ICH-induced brain edema and DNA injury suggesting that serine protease inhibitor may be potential therapeutic agent for ICH...
  11. doi request reprint Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils
    Feng Lu
    Department of Neurobiology, Kagawa University Faculty of Medicine, Miki, Japan
    Neurosci Lett 506:28-32. 2012
    ..These findings suggest that edaravone inhibits oxidative stress and attenuates neuronal damage induced by transient forebrain ischemia in gerbils and which may contribute to improvements in behavioral deficits...
  12. doi request reprint Neuroprotective effects of angiotensin II type 1 receptor (AT1-R) blocker via modulating AT1-R signaling and decreased extracellular glutamate levels
    Tomoyoshi Fujita
    Department of Ophthalmology, Kagawa University, Kagawa, Japan
    Invest Ophthalmol Vis Sci 53:4099-110. 2012
    ..To investigate the mechanism of the neuroprotective effects of the angiotensin II type 1 receptor (AT1-R) blocker against retinal ischemia-reperfusion injury in the rat...
  13. doi request reprint Eicosapentaenoic acid prevents memory impairment after ischemia by inhibiting inflammatory response and oxidative damage
    Naohiko Okabe
    Department of Neurobiology, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Miki, Kagawa, Japan
    J Stroke Cerebrovasc Dis 20:188-95. 2011
    ..05). These findings suggest that EPA inhibits the inflammatory reaction and oxidative damage occurring after ischemic brain injury, and also may contribute to the prevention of neural damage and memory impairment following such injury...
  14. doi request reprint D-allose as ischemic retina injury inhibitor during rabbit vitrectomy
    Masanori Mizote
    Department of Ophthalmology, Kagawa Prefectural Central Hospital, 5 4 16 Ban, Takamatu, Kagawa, 760 8557, Japan
    Jpn J Ophthalmol 55:294-300. 2011
    ..To investigate the protective effects of D-allose, a rare sugar, on pressure-induced ischemia during vitrectomy in the rabbit eye...
  15. doi request reprint 3'-Deoxy-3'-[(18)F]-fluorothymidine ([(18)F]-FLT) transport in newly diagnosed glioma: correlation with nucleoside transporter expression, vascularization, and blood-brain barrier permeability
    Aya Shinomiya
    Department of Neurological Surgery, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Miki, Kagawa, 761 0173, Japan
    Brain Tumor Pathol 30:215-23. 2013
    ..This preliminary study suggests that ENT1 expression might not reflect accumulation of [(18)F]-FLT in vivo due to BBB permeability in glioma...
  16. doi request reprint Effect of delayed mild brain hypothermia on edema formation after intracerebral hemorrhage in rats
    Masahiko Kawanishi
    Department of Neurological Surgery, Kagawa University School of Medicine, Kagawa, Japan
    J Stroke Cerebrovasc Dis 17:187-95. 2008
    ..Several neuroprotective mechanisms, including reduced BBB disruption, inflammation and oxidative damage, are suggested in this study...
  17. doi request reprint Activation of the aldosterone/mineralocorticoid receptor system and protective effects of mineralocorticoid receptor antagonism in retinal ischemia-reperfusion injury
    Ye Liu
    Department of Ophthalmology, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Miki, Kagawa 761 0793, Japan
    Exp Eye Res 96:116-23. 2012
    ..The present findings demonstrated the existence of a local aldosterone/MR system in the retina. Our results also demonstrated that an MR antagonist can attenuate subsequent ischemic damage in the rat retina...
  18. pmc Plasma brain natriuretic peptide as a surrogate marker for cardioembolic stroke
    Kazushi Yukiiri
    Department of Cardiorenal and Cerebrovascular Medicine, Division of Stroke, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kagawa 761 0793, Japan
    BMC Neurol 8:45. 2008
    ....
  19. ncbi request reprint Metabolic disturbance without brain ischemia in traumatic brain injury: a positron emission tomography study
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University School of Medicine, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    Acta Neurochir Suppl 102:241-5. 2008
    ..Cerebral ischemia is believed to be an important mechanism of secondary neuronal injury in traumatic brain injury (TBI)...
  20. ncbi request reprint Seizure suppression in amygdala-kindled mice by transplantation of neural stem/progenitor cells derived from mouse embryonic stem cells
    Atsushi Shindo
    Department of Neurological Surgery, Kagawa University Faculty of Medicine, Kagawa
    Neurol Med Chir (Tokyo) 50:98-105; disucussion 105-6. 2010
    ..NS/PCs derived from ES cells have high potential for use in transplantation therapy for clinically intractable epilepsies...
  21. doi request reprint Ameliorative effects of yokukansan on behavioral deficits in a gerbil model of global cerebral ischemia
    Yanan Liu
    Department of Neurobiology, Kagawa University Faculty of Medicine, Miki, Japan
    Brain Res 1543:300-7. 2014
    ....
  22. ncbi request reprint [Brain hypothermia for ischemic brain damage]
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa Medical University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    No Shinkei Geka 30:1273-83. 2002
  23. doi request reprint Evaluation of 3'-deoxy-3'-[18F]-fluorothymidine (18F-FLT) kinetics correlated with thymidine kinase-1 expression and cell proliferation in newly diagnosed gliomas
    Aya Shinomiya
    Department of Neurological Surgery, Kagawa University Faculty of Medicine, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    Eur J Nucl Med Mol Imaging 40:175-85. 2013
    ....
  24. ncbi request reprint [Case of metastatic malignant melanoma detected by multifocal cerebral hemorrhage]
    Aya Shinomiya
    Department of Neurological Surgery, Kagawa University, Kagawa, Japan
    No Shinkei Geka 40:261-9. 2012
    ..We think that the development of a therapeutic strategy for the treatment of intracranial metastatic malignant melanoma, including its risk management of intracerebral hemorrhage would be great importance...
  25. doi request reprint Neuroprotection against retinal ischemia-reperfusion injury by blocking the angiotensin II type 1 receptor
    Kouki Fukuda
    Departments of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan
    Invest Ophthalmol Vis Sci 51:3629-38. 2010
    ..Both the ACE inhibitor and the AT1-R antagonist that were examined can block the stimulation of the AT1-R and attenuate the subsequent ischemic damage in the rat retina...
  26. ncbi request reprint Parietal lipomeningocele--case report
    Shiro Yamashita
    Department of Neurological Surgery, Kagawa University School of Medicine, Kagawa, Japan
    Neurol Med Chir (Tokyo) 45:112-5. 2005
    ..In the present case, the intracranial lipoma was associated with the cranium bifidum, and dysraphism was possibly involved in the pathogenesis. Resection of only the extracranial subcutaneous tumor can be performed for cosmetic reasons...
  27. ncbi request reprint Role of the hippocampal CA2 region following postischemic hypothermia in gerbil
    Shiro Yamashita
    Department of Neurological Surgery, Kagawa Medical University, Ikenobe, Miki, Kagawa 761 0793, Japan
    Brain Res Mol Brain Res 111:8-16. 2003
    ..These results suggest that the changes in NR1 and GluR2 receptors at the mRNA level would occur in spite of postischemic hypothermia. The phenomenon in the CA2 region may play an important role to rescue neuronal cell death by ischemia...
  28. ncbi request reprint Delayed precursor cell markers expression in hippocampus following cold-induced cortical injury in mice
    Takehiro Nakamura
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan, USA
    J Neurotrauma 21:1747-55. 2004
    ..The present study suggests that the delayed nestin expression in glia and neuron-like cells might be part of the adaptation to injury...
  29. ncbi request reprint Anti-inflammatory effect of D-allose in cerebral ischemia/reperfusion injury in rats
    Dakuan Gao
    Department of Neurological Surgery, Kagawa University Faculty of Medicine, Japan
    Neurol Med Chir (Tokyo) 53:365-74. 2013
    ..Treatment with D-allose might provide a new strategy and clinically beneficial outcome for acute ischemic stroke. ..
  30. ncbi request reprint Effects of mild hypothermia and alkalizing agents on brain injuries in rats with acute subdural hematomas
    Masanobu Okauchi
    Department of Neurological Surgery, Kagawa Medical University, Kagawa, Japan
    J Neurotrauma 19:741-51. 2002
    ..The protection of the BBB is one of the possible cerebroprotective mechanisms in this rat acute SDH model...
  31. doi request reprint Differential gene expression of 36-kDa microfibril-associated glycoprotein (MAGP-36/MFAP4) in rat organs
    Tetsuhiko Toyoshima
    Department of Structure and Functional Medicine, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kagawa 761 0793, Japan
    Cell Tissue Res 332:271-8. 2008
    ..Since MAGP-36 is known to bind to mannan, MAGP-36 might be involved in mannose transport in the S3 segment. Thus, MAGP-36 might be multifunctional and present in a wide variety of sites in various organs...
  32. doi request reprint Predictors of intracerebral hemorrhage severity and its outcome in Japanese stroke patients
    Naohisa Hosomi
    Kagawa University School of Medicine, Kagawa, Japan
    Cerebrovasc Dis 27:67-74. 2009
    ..The aim of this investigation was to determine the factors influencing acute intracerebral hemorrhage severity on admission and clinical outcomes at discharge...
  33. ncbi request reprint Intracerebral hemorrhage in mice: model characterization and application for genetically modified mice
    Takehiro Nakamura
    Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA
    J Cereb Blood Flow Metab 24:487-94. 2004
    ..05). These findings suggest that the mouse ICH model is a reproducible and feasible model. These results also suggest that gender and complement C5 are factors affecting brain injury after ICH...
  34. ncbi request reprint Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage
    Takehiro Nakamura
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109 0532, USA
    Neurosurg Focus 15:ECP4. 2003
    ..In the present study they investigated whether deferoxamine, an iron chelator, can reduce ICH-induced brain injury...
  35. ncbi request reprint Holo-transferrin and thrombin can interact to cause brain damage
    Takehiro Nakamura
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109 0532, USA
    Stroke 36:348-52. 2005
    ....
  36. ncbi request reprint Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage
    Takehiro Nakamura
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109 0532, USA
    J Neurosurg 100:672-8. 2004
    ..In the present study the authors investigate whether deferoxamine, an iron chelator, can reduce ICH-induced brain injury...
  37. ncbi request reprint Oxidative DNA injury after experimental intracerebral hemorrhage
    Takehiro Nakamura
    Department of Neurosurgery, University of Michigan, 5550 Kresge I, Ann Arbor, MI 48109 0532, USA
    Brain Res 1039:30-6. 2005
    ..These results suggest that oxidative stress contributes to DNA damage and brain injury after ICH. Reducing DNA oxidative damage (for example, through iron chelation) may be a therapeutic target for ICH...
  38. ncbi request reprint Estrogen therapy for experimental intracerebral hemorrhage in rats
    Takehiro Nakamura
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109 0532, USA
    J Neurosurg 103:97-103. 2005
    ....
  39. ncbi request reprint Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice
    Tohru Uchida
    Division of Diabetes and Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Nat Med 11:175-82. 2005
    ..Thus, p27(Kip1) contributes to beta-cell failure during the development of type 2 diabetes in Irs2(-/-) and Lepr(-/-) mice and represents a potential new target for the treatment of this condition...
  40. ncbi request reprint Tumor necrosis factor-alpha increases in the brain after intracerebral hemorrhage and thrombin stimulation
    Ya Hua
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109 0532, USA
    Neurosurgery 58:542-50; discussion 542-50. 2006
    ....
  41. ncbi request reprint The role of complement C3 in intracerebral hemorrhage-induced brain injury
    Shuxu Yang
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109 0532, USA
    J Cereb Blood Flow Metab 26:1490-5. 2006
    ..These results suggest complement activation may affect heme metabolism and the inflammatory response after ICH suggesting that complement C3 is an important factor causing ICH-induced brain injury...
  42. doi request reprint Effects of thrombin on neurogenesis after intracerebral hemorrhage
    Shuxu Yang
    Department of Neurosurgery, University of Michigan, Ann Arbor 48109, USA
    Stroke 39:2079-84. 2008
    ..Thrombin formation causes acute brain injury after ICH, but thrombin also can stimulate cell proliferation. The present study examined whether neurogenesis takes place in ICH and the role of thrombin in ICH-related neurogenesis...
  43. ncbi request reprint [Early case of idiopathic pulmonary alveolar proteinosis positive for serum anti-GM-CSF antibody]
    Kei Yamasaki
    Division of Respiratory Diseases, University of Occupational and Environmental Health
    Nihon Kokyuki Gakkai Zasshi 46:712-6. 2008
    ..Anti-GM-CSF antibody of serum was also positive (7.908 microg/ml). Based on these findings, we decided this was an early case of idiopathic pulmonary alveolar proteinosis...
  44. ncbi request reprint Iron and iron-handling proteins in the brain after intracerebral hemorrhage
    Jimin Wu
    Department of Neurosurgery, University of Michigan, Ann Arbor 48109 0532, USA
    Stroke 34:2964-9. 2003
    ..Therefore, we examined whether such iron is cleared from the brain and the effects of ICH on proteins that may alter iron release or handling: brain heme oxygenase-1, transferrin, transferrin receptor, and ferritin...