Hirohito Mori

Summary

Affiliation: Kagawa University
Country: Japan

Publications

  1. pmc Comparison of postoperative complications after endoscopic submucosal dissection: differences of insufflations and anesthesias
    Hirohito Mori
    Department of Gastroenterology and Neurology, Kagawa Medical University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Diagn Ther Endosc 2011:709237. 2011
  2. doi request reprint Feasibility of pure EFTR using an innovative new endoscopic suturing device: the Double-arm-bar Suturing System (with video)
    Hirohito Mori
    Department of Gastroenterology and Neurology, Kagawa University, 1750 1 Ikenobe, Miki, Kita, Kagawa, 761 0793, Japan
    Surg Endosc 28:683-90. 2014
  3. pmc Radical excision of Barrett's esophagus and complete recovery of normal squamous epithelium
    Hirohito Mori
    Department of Gastroenterology and Neurology, Kagawa University, Kagawa 761 0793, Japan
    World J Gastroenterol 19:5195-8. 2013
  4. pmc Accurate hemostasis with a new endoscopic overtube for emergency endoscopy
    Hirohito Mori
    Departments of Gastroenterology and Neurology, Kagawa Medical University School of Medicine, Kagawa 761 0793, Japan
    World J Gastroenterol 19:2723-6. 2013
  5. doi request reprint New flexible endoscopic full-thickness suturing device: a triple-arm-bar suturing system
    H Mori
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Endoscopy 45:649-54. 2013
  6. doi request reprint Establishment of pure NOTES procedure using a conventional flexible endoscope: review of six cases of gastric gastrointestinal stromal tumors
    H Mori
    Department of Gastroenterology and Neurology, Kagawa Medical University School of Medicine, Kagawa, Japan
    Endoscopy 43:631-4. 2011
  7. pmc Rectal perforations and fistulae secondary to a glycerin enema: closure by over-the-scope-clip
    Hirohito Mori
    Department of Gastroenterology and Neurology, Kagawa Medical University School of Medicine, Kagawa 761 0793, Japan
    World J Gastroenterol 18:3177-80. 2012
  8. pmc Cytomegalovirus-associated gastric ulcer: a side effect of steroid injections for pyloric stenosis
    Hirohito Mori
    Departments of Gastroenterology and Neurology, Kagawa Medical University School of Medicine, Kagawa 761 0793, Japan
    World J Gastroenterol 19:1143-6. 2013
  9. pmc Effects of gastric irrigation on bacterial counts before endoscopic submucosal dissection: a randomized case control prospective study
    Hirohito Mori
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    PLoS ONE 8:e65377. 2013
  10. ncbi request reprint Recanalization of severe gastric antral stricture after large endoscopic submucosal dissection: mucosal incision and local steroid injection
    Hirohito Mori
    Department of Gastroeneterology, Kagawa Medical University School of Medicine, Kagawa, Japan
    J Gastrointestin Liver Dis 21:435-7. 2012

Collaborators

Detail Information

Publications68

  1. pmc Comparison of postoperative complications after endoscopic submucosal dissection: differences of insufflations and anesthesias
    Hirohito Mori
    Department of Gastroenterology and Neurology, Kagawa Medical University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Diagn Ther Endosc 2011:709237. 2011
    ..0371). CO(2) insufflation and general anesthesia are useful in stabilizing intraoperative conditions and reducing postoperative complications...
  2. doi request reprint Feasibility of pure EFTR using an innovative new endoscopic suturing device: the Double-arm-bar Suturing System (with video)
    Hirohito Mori
    Department of Gastroenterology and Neurology, Kagawa University, 1750 1 Ikenobe, Miki, Kita, Kagawa, 761 0793, Japan
    Surg Endosc 28:683-90. 2014
    ..Endoscopic full-thickness resection (EFTR) requires a reliable full-thickness suturing device and an endoscopic counter-traction device to prevent the collapse of the digestive tract...
  3. pmc Radical excision of Barrett's esophagus and complete recovery of normal squamous epithelium
    Hirohito Mori
    Department of Gastroenterology and Neurology, Kagawa University, Kagawa 761 0793, Japan
    World J Gastroenterol 19:5195-8. 2013
    ..We performed endoscopic submucosal dissection as complete radically curable treatment procedure for BE with dysplasia, intestinal metaplasia and BAC. ..
  4. pmc Accurate hemostasis with a new endoscopic overtube for emergency endoscopy
    Hirohito Mori
    Departments of Gastroenterology and Neurology, Kagawa Medical University School of Medicine, Kagawa 761 0793, Japan
    World J Gastroenterol 19:2723-6. 2013
    ..The inverted overtube helped us obtain a clear view in patients who were laid in the right lateral position. Rapid identification of exposed vessels resulted in success of hemostasis...
  5. doi request reprint New flexible endoscopic full-thickness suturing device: a triple-arm-bar suturing system
    H Mori
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Endoscopy 45:649-54. 2013
    ..A reliable full-thickness suturing device is necessary for pure natural orifice transluminal endoscopic surgery (NOTES). The present study focused on assessing the reliability of a new suturing device...
  6. doi request reprint Establishment of pure NOTES procedure using a conventional flexible endoscope: review of six cases of gastric gastrointestinal stromal tumors
    H Mori
    Department of Gastroenterology and Neurology, Kagawa Medical University School of Medicine, Kagawa, Japan
    Endoscopy 43:631-4. 2011
    ....
  7. pmc Rectal perforations and fistulae secondary to a glycerin enema: closure by over-the-scope-clip
    Hirohito Mori
    Department of Gastroenterology and Neurology, Kagawa Medical University School of Medicine, Kagawa 761 0793, Japan
    World J Gastroenterol 18:3177-80. 2012
    ..Our two cases are the first reports of the successful endoscopic closure of fistulae using double OTSCs after endoscopic lavage of the debris and an abscess of the rectum secondary to a GE...
  8. pmc Cytomegalovirus-associated gastric ulcer: a side effect of steroid injections for pyloric stenosis
    Hirohito Mori
    Departments of Gastroenterology and Neurology, Kagawa Medical University School of Medicine, Kagawa 761 0793, Japan
    World J Gastroenterol 19:1143-6. 2013
    ..Biopsies revealed large cells with intranuclear inclusion bodies, which stained positive for the anti-CMV antibody. Local TA injections are useful, however, CMV ulcer might occur as adverse events...
  9. pmc Effects of gastric irrigation on bacterial counts before endoscopic submucosal dissection: a randomized case control prospective study
    Hirohito Mori
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    PLoS ONE 8:e65377. 2013
    ..The aim of the randomized prospective study is to evaluate the antiseptic effects of gastric irrigation of saline solution before ESD by evaluating bacterial count...
  10. ncbi request reprint Recanalization of severe gastric antral stricture after large endoscopic submucosal dissection: mucosal incision and local steroid injection
    Hirohito Mori
    Department of Gastroeneterology, Kagawa Medical University School of Medicine, Kagawa, Japan
    J Gastrointestin Liver Dis 21:435-7. 2012
    ..Making a mucosal incision on the opposite side of post ESD ulcer and cutting the submucosal layer eases the mucosal tension, and the local injection of TA into a large artificial ulcer following ESD can prevent re-stenosis...
  11. ncbi request reprint Successful closing of duodenal ulcer after endoscopic submucosal dissection with over-the-scope clip to prevent delayed perforation
    Hirohito Mori
    Departments of Gastroenterology and Neurology, Kagawa University Medical School, Kagawa, Japan
    Dig Endosc 25:459-61. 2013
    ..In these two clinical cases, we successfully carried out complete closures of post-ESD duodenal ulcer using OTSC without any complications. ..
  12. doi request reprint Innovative noninsufflation EFTR: sufficient endoscopic operative field by mechanical counter traction device
    Hirohito Mori
    Department of Gastroenterology, Kagawa University Medicine School, 1750 1 Ikenobe, Kita, Miki, 761 0793 Kagawa, Japan
    Surg Endosc 27:3028-34. 2013
    ....
  13. doi request reprint Steroid permeation into the artificial ulcer by combined steroid gel application and balloon dilatation: prevention of esophageal stricture
    Hirohito Mori
    Department of Gastroenterology and Neurology, Kagawa University Medical School, Kagawa, Japan
    J Gastroenterol Hepatol 28:999-1003. 2013
    ..We evaluated the effectiveness of the application of triamcinolone acetonide gel following permeation into a large artificial ESD ulcer by balloon dilatation compared with steroid injection...
  14. doi request reprint Local steroid injection into the artificial ulcer created by endoscopic submucosal dissection for gastric cancer: prevention of gastric deformity
    H Mori
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Endoscopy 44:641-8. 2012
    ..The aim of the current study was to evaluate therapeutic efficacy in the prevention of gastric deformity of local triamcinolone acetonide (TCA) injection into the extensive artificial ulcer following ESD...
  15. doi request reprint New technique for safer endoscopic submucosal dissection using the duodenal balloon occlusion method
    Hirohito Mori
    Department of Gastroenterology and Neurology, Kagawa Medical University School of Medicine, Kagawa, Japan
    J Gastroenterol Hepatol 27:81-5. 2012
    ..We aimed to reduce the incidence of an enlarged feeling of the abdomen by wedging a balloon in the bulbus duodeni to reduce air flow into the lower parts of the GI tract...
  16. pmc Effectiveness of CO2-insufflated endoscopic submucosal dissection with the duodenal balloon occlusion method for early esophageal or gastric cancer: a randomized case control prospective study
    Hirohito Mori
    Department of Gastroenterology and Neurology, 1750 1 Ikenobe, Miki, Kita, Kagawa, Japan
    BMC Gastroenterol 12:37. 2012
    ..This prospective study was designed to compare the CO2 concentration, intestinal volume, and acid-base balance using the duodenal balloon procedure...
  17. pmc Effects of angiotensin II AT₁-receptor blockade on high fat diet-induced vascular oxidative stress and endothelial dysfunction in Dahl salt-sensitive rats
    Shinji Kosaka
    Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
    J Pharmacol Sci 121:95-102. 2013
    ..Inhibition of angiotensin II AT₁ receptors may elicit beneficial effects on HF-induced hypertension and vascular injury in subjects that have genetically enhanced sodium-sensitive blood pressure...
  18. pmc Angiotensin-converting enzyme inhibitor does not suppress renal angiotensin II levels in angiotensin I-infused rats
    Keisuke Ohnishi
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    J Pharmacol Sci 122:103-8. 2013
    ....
  19. doi request reprint Antitumor effect of metformin in esophageal cancer: in vitro study
    Mitsuyoshi Kobayashi
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Int J Oncol 42:517-24. 2013
    ..In addition, the expression of miRNAs was markedly altered with the treatment of metformin in vitro. Metformin inhibited the growth of three ESCC cell lines, and this inhibition may have involved reductions in cyclin D1, Cdk4 and Cdk6...
  20. pmc [18F]Fluorodeoxyglucose accumulation as a biological marker of hypoxic status but not glucose transport ability in gastric cancer
    Ryusuke Takebayashi
    Department of Gastroenterological Surgery, Kagawa University, Miki, Kita, Kagawa, Japan
    J Exp Clin Cancer Res 32:34. 2013
    ..The purpose of this study was to clarify the molecular mechanisms involved in FDG uptake...
  21. doi request reprint The efficacy and safety of prophylactic closure for a large mucosal defect after colorectal endoscopic submucosal dissection
    Shintaro Fujihara
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Oncol Rep 30:85-90. 2013
    ..Without increasing adverse effects, the prophylactic closure efficiently reduced the inflammatory reaction and abdominal symptoms of colorectal ESD in patients with large superficial colorectal neoplasms...
  22. pmc Efficacy and safety of over-the-scope clip: including complications after endoscopic submucosal dissection
    Noriko Nishiyama
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa 761 0796, Japan
    World J Gastroenterol 19:2752-60. 2013
    ..To retrospectively review the results of over-the-scope clip (OTSC) use in our hospital and to examine the feasibility of using the OTSC to treat perforations after endoscopic submucosal dissection (ESD)...
  23. pmc Add-on aliskiren elicits stronger renoprotection than high-dose valsartan in type 2 diabetic KKAy mice that do not respond to low-dose valsartan
    Bai Lei
    Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
    J Pharmacol Sci 119:131-8. 2012
    ..In conclusion, the anti-albuminuric effect that was observed in the type 2 diabetic mice showing no anti-albuminuric effect by valsartan can be attributed to the add-on aliskiren...
  24. pmc Roles of Na⁺/H⁺ exchanger type 1 and intracellular pH in angiotensin II-induced reactive oxygen species generation and podocyte apoptosis
    Ya Liu
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Japan
    J Pharmacol Sci 122:176-83. 2013
    ....
  25. pmc Endoscopic management of a rare granulation polyp in a colonic diverticulum
    Hirohito Mori
    Hirohito Mori, Hideki Kobara, Noriko Nishiyama, Shintaro Fujihara, Tae Matsunaga, Maki Ayagi, Tatsuo Yachida, Tsutomu Masaki, Departments of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa 761 0793, Japan
    World J Gastroenterol 19:9481-4. 2013
    ..If a granulomatous polyp could arise from a diverticulum, differential diagnosis between a colon neoplasm and a granulomatous polyp would not only be difficult but also necessary for suitable endoscopic treatment. ..
  26. pmc N-type calcium channel inhibition with cilnidipine elicits glomerular podocyte protection independent of sympathetic nerve inhibition
    Bai Lei
    Department of Pharmacology, Kagawa University Medical School, Japan
    J Pharmacol Sci 119:359-67. 2012
    ..These data indicate that renal nerves have a limited contribution to the cilnidipine-induced reno-protective effects in HS-UNX-SHR...
  27. ncbi request reprint Gastric heterotopic pancreas can be identified by endoscopic direct imaging with submucosal endoscopy
    Hideki Kobara
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan Email
    J Gastrointestin Liver Dis 22:345-8. 2013
    ..Our findings indicate that the characteristic EDI findings of gastric HP may distinguish these lesions from neoplastic SMTs. Additional evaluations of this approach are warranted. ..
  28. pmc Bleeding duodenal hemangioma: morphological changes and endoscopic mucosal resection
    Noriko Nishiyama
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa Medical University, 1750 1 Miki, Kita, Kagawa 761 0793, Japan
    World J Gastroenterol 18:2872-6. 2012
    ..Interestingly, duodenal hemangiomas show morphological changes that are influenced by various factors, such as mechanical stimuli...
  29. pmc A case of plasmablastic lymphoma of the liver without human immunodeficiency virus infection
    Joji Tani
    Joji Tani, Hisaaki Miyoshi, Takako Nomura, Hirohito Yoneyama, Hideki Kobara, Hirohito Mori, Asahiro Morishita, Takashi Himoto, Tsutomu Masaki, Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Kagawa 761 0793, Japan
    World J Gastroenterol 19:6299-303. 2013
    ..The autopsy findings suggested a diagnosis of PBL. To our knowledge, the present case appears to be the first report of PBL with initial presentation of the liver in a patient without HIV infection...
  30. pmc Aldosterone induces p21-regulated apoptosis via increased synthesis and secretion of tumour necrosis factor-α in human proximal tubular cells
    Kento Kitada
    Department of Pharmacology, Kagawa University, Kagawa, Japan
    Clin Exp Pharmacol Physiol 39:858-63. 2012
    ....
  31. pmc Difficulty in differentiating two cases of sigmoid stenosis by diverticulitis from cancer
    Noriko Nishiyama
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    World J Gastroenterol 18:3623-6. 2012
    ..A partial sigmoidectomy was performed. Pathological examination of the resected specimen revealed no changes in the mucosal epithelial surface, but a marked infiltration of inflammatory cells was observed...
  32. pmc Current innovations in endoscopic therapy for the management of colorectal cancer: from endoscopic submucosal dissection to endoscopic full-thickness resection
    Shintaro Fujihara
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Biomed Res Int 2014:925058. 2014
    ..The present paper aims to discuss the complementary role of ESD and the future development of EFTR. We focus on the possibility of achieving EFTR using the ESD method and closing devices. ..
  33. pmc Aldosterone does not contribute to renal p21 expression during the development of angiotensin II-induced hypertension in mice
    Daisuke Nakano
    Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
    Am J Hypertens 25:354-8. 2012
    ..In the present study, we investigated the contribution of aldosterone to the renal p21 expression and senescence during the development of angiotensin II (AngII)-induced hypertension...
  34. pmc An effective and safe gastric endoscopic submucosal dissection in the right lateral position using an inverted overtube
    Hirohito Mori
    Hirohito Mori, Kazi Rafiq, Hideki Kobara, Noriko Nishiyama, Shintaro Fujihara, Tatsuo Yachida, Maki Ayagi, Joji Tani, Hisaaki Miyoshi, Tsutomu Masaki, Department of Gastroenterology and Neurology, Kagawa University, Kagawa 761 0793, Japan
    World J Gastroenterol 20:1623-5. 2014
    ..In this position, the distance to gastric mucosa is reduced, and the angle of the electric knife changes from vertical to somewhat oblique, facilitating safer cutting. ..
  35. pmc Influence of percutaneous local therapy for hepatocellular carcinoma on gastric function
    Mitsuyoshi Kobayashi
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki cho, Kita gun, Kagawa 761 0793, Japan
    World J Gastroenterol 19:1618-24. 2013
    ..To investigate the influence of percutaneous local therapy on gastric myoelectrical activity in patients with hepatocellular carcinomas...
  36. pmc Calcium Channel Blocker Enhances Beneficial Effects of an Angiotensin II AT1 Receptor Blocker against Cerebrovascular-Renal Injury in type 2 Diabetic Mice
    Kazi Rafiq
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    PLoS ONE 8:e82082. 2013
    ..These data support the hypothesis that a CCB enhances ARB-associated cerebrovascular-renal protective effects through suppression of NADPH oxidase-dependent oxidative stress in type 2 diabetes. ..
  37. pmc Aldosterone aggravates glucose intolerance induced by high fructose
    Shamshad J Sherajee
    Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Eur J Pharmacol 720:63-8. 2013
    ..In conclusion, these data suggested that aldosterone aggravates fructose feeding-induced glucose intolerance through MR activation...
  38. pmc Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3
    Masahiro Moritoki
    Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan
    PLoS ONE 8:e60807. 2013
    ..Collectively, it is likely that galectin-9 attenuates the clinical severity of MRL lupus-prone mice by regulating T cell function and inducing plasma cell apoptosis...
  39. ncbi request reprint An iatrogenic sigmoid perforation caused by an aortobifemoral graft mimicking an advanced colon cancer
    Shintaro Fujihara
    Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Japan
    Intern Med 52:355-7. 2013
    ..As a result, secondary aortoenteric fistulae should therefore be considered in any patient presenting with gastrointestinal bleeding and a history of aortic surgery...
  40. pmc Role of (pro)renin receptor in Ang II-mediated EGF receptor transactivation
    Yuki Shibayama
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Front Biosci (Elite Ed) 5:697-705. 2013
    ..Incubation with prorenin significantly increased Ang II levels of cell lysate. These data indicate that the (pro)renin receptor mediates EGF receptor transactivation in both Ang II-dependent and -independent pathways...
  41. doi request reprint Prediction of invasion depth for submucosal differentiated gastric cancer by magnifying endoscopy with narrow-band imaging
    Hideki Kobara
    Department of Gastroenterology and Neurology, Life Science Research Center, Kagawa Medical University School of Medicine, and Department of Gastroenterology, Kagawa Rosai Hospital, Kagawa 761 0793, Japan
    Oncol Rep 28:841-7. 2012
    ..05). NBI-ME findings of non-structure, scattery vessels and multi-caliber vessels can possibly serve as indicators of SM2 invasion in differentiated D-GC. Scoring of the three indicators was significant...
  42. doi request reprint Expression of angiogenic factors in hepatocarcinogenesis: Identification by antibody arrays
    Takako Nomura
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Oncol Rep 30:2476-80. 2013
    ..Therefore, the analysis of the expression of these cytokines using protein arrays may identify novel therapies for individual patients with HCC. ..
  43. pmc Two rare gastric hamartomatous inverted polyp cases suggest the pathogenesis of growth
    Hirohito Mori
    Hirohito Mori, Hideki Kobara, Shintaro Fujihara, Noriko Nishiyama, Tae Matsunaga, Maki Ayaki, Tatsuo Yachida, Tsutomu Masaki, Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki, Kita, Kagawa 761 0793, Japan
    World J Gastroenterol 20:5918-23. 2014
    ..Regarding the pathogenesis of GHIP, a submucosal hamartomatous change may occur prior to the growth of hypertrophic portions. An en bloc resection using ESD is recommended for treatment. ..
  44. ncbi request reprint Effect of the anti-diabetic drug metformin in hepatocellular carcinoma in vitro and in vivo
    Hisaaki Miyoshi
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Int J Oncol 45:322-32. 2014
    ..Our results demonstrate that metformin inhibits the growth of HCC, possibly by inducing G1 cell cycle arrest through the alteration of microRNAs...
  45. pmc Oxidative stress-induced glomerular mineralocorticoid receptor activation limits the benefit of salt reduction in Dahl salt-sensitive rats
    Kento Kitada
    Department of Pharmacology, Kagawa University, Kagawa, Japan
    PLoS ONE 7:e41896. 2012
    ..Furthermore, we determined if MR activation persisted and induced renal injury, even after switching from a high- to a normal-salt diet...
  46. ncbi request reprint Omental flap wrapping with fixation to the cut surface of the liver for reducing delayed gastric emptying after left-sided hepatectomy
    Keiichi Okano
    Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    Surg Today 43:1425-32. 2013
    ..The goal of this study was to clarify the clinical implications of an omental flap wrapping procedure that includes fixation to the cut surface of the liver to reduce the incidence of DGE after left-sided hepatectomy...
  47. pmc Chymase activities and survival in endotoxin-induced human chymase transgenic mice
    Kazi Rafiq
    1 Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
    Int J Med Sci 11:222-5. 2014
    ..LPS-induced increases in chymase activity in the heart and skin were significantly greater in Tg than WT mice. These data suggest a possible contribution of human chymase activation to LPS-induced mortality. ..
  48. pmc Angiotensin II blockade and renal protection
    Hiroyuki Kobori
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Ikenobe 1750 1, Miki, Kita, Kagawa 761 0793, Japan
    Curr Pharm Des 19:3033-42. 2013
    ..We will also discuss the possible mechanisms responsible for the renoprotective effects of ARBs on type 2 diabetic nephropathy...
  49. pmc Metabolic syndrome, obesity, and gastrointestinal cancer
    Shintaro Fujihara
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Takamatsu, Kagawa 761 0793, Japan
    Gastroenterol Res Pract 2012:483623. 2012
    ..This paper synthesizes the evidence on key molecular mechanisms underlying the obesity-cancer link...
  50. pmc Differences in the Characteristics of Barrett's Esophagus and Barrett's Adenocarcinoma between the United States and Japan
    Makoto Oryu
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Takamatsu, Kagawa 761 0793, Japan
    ISRN Gastroenterol 2013:840690. 2013
    ..In this paper, we focus on specific differences in the background factors and pathophysiology of these lesions...
  51. pmc Active bleeding from a periampullary duodenal diverticulum that was difficult to diagnose but successfully treated using hemostatic forceps: a case report
    Noriko Nishiyama
    Departments of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750 1 Miki, Kagawa, Kita, 761 0793, Japan
    J Med Case Rep 6:367. 2012
    ..abstract:..
  52. pmc High sodium augments angiotensin II-induced vascular smooth muscle cell proliferation through the ERK 1/2-dependent pathway
    Gang Liu
    1 Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan 2 Department of Anesthesiology, First Affiliated Hospital of China Medical University, Shenyang, China
    Hypertens Res 37:13-8. 2014
    ..These data suggest that high-sodium level directly augments Ang II-induced VSMC proliferation through NHE-1- and ERK 1/2-dependent pathways and may offer new insights into the mechanisms of vascular remodeling by high-sodium/Ang II. ..
  53. doi request reprint (Pro)renin receptor and insulin resistance: possible roles of angiotensin II-dependent and -independent pathways
    Kazi Rafiq
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Mol Cell Endocrinol 378:41-5. 2013
    ..In this review, we will summarized the current knowledge regarding the possible contribution of (P)RR to the pathophysiology of insulin resistance. ..
  54. ncbi request reprint Esophageal anthracosis with tuberculous lymphadenitis confirmed on transesophageal endoscopic ultrasound-guided fine-needle aspiration
    Noriko Nishiyama
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Japan
    Intern Med 53:577-80. 2014
    ..If no esophageal anthracotic lesions are found on the mucous membrane layer of the esophagus, transesophageal endoscopic ultrasound-guided fine-needle aspiration is a suitable approach for diagnosing esophageal anthracosis. ..
  55. pmc Life-threatening gastrointestinal bleeding during targeted therapy for advanced renal cell carcinoma: a case report
    Shintaro Fujihara
    Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine Graduate School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa prefecture 761 0793, Japan
    BMC Nephrol 14:141. 2013
    ..This is the first case report of such an adverse drug reaction in the literature...
  56. ncbi request reprint Galectin-9 in cancer therapy
    Shintaro Fujihara
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita gun, Kagawa, Japan
    Recent Pat Endocr Metab Immune Drug Discov 7:130-7. 2013
    ..Here, we review the biology and physiological role of galectin-9, and discuss the therapeutic potential of galectin-9 in cancer as well as relevant patents...
  57. doi request reprint Molecular mechanisms of [18F]fluorodeoxyglucose accumulation in liver cancer
    Kunihiko Izuishi
    Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University, Miki, Kita, Kagawa 761 0793, Japan
    Oncol Rep 31:701-6. 2014
    ..These results may explain why M/D HCC is not detected as sensitively by FDG-PET...
  58. pmc Endoscopic hemostasis with endoscopic mucosal resection and multiple synchronous early gastric cancers: a case report
    Shintaro Fujihara
    Department of Gastroenterology and Neurology, Kagawa University, Faculty of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa prefecture 761 0793, Japan
    J Med Case Rep 6:268. 2012
    ..abstract:..
  59. doi request reprint Roles of central renin-angiotensin system and afferent renal nerve in the control of systemic hemodynamics in rats
    Yoshihide Fujisawa
    Life Science Research Center, Faculty of Medicine, Kagawa University, Ikenobe, Miki cho, Kita gun, Japan
    Hypertens Res 34:1228-32. 2011
    ..These results indicate that signals transmitted by ARNs have an important role in the control of systemic hemodynamics through regulating central RAS-mediated changes in sympathetic nerve activity...
  60. doi request reprint Giant gastric ulcer penetrating into the pancreas
    Shintaro Fujihara
    Department of Gastroenterology and Neurology, Kagawa University, Faculty of Medicine, Japan
    Arab J Gastroenterol 13:158-60. 2012
    ..Antral and duodenal ulcers can penetrate into the pancreas. We report a case of gastric ulcer penetrating into the pancreas...
  61. pmc Effect of efonidipine on TGF-β1-induced cardiac fibrosis through Smad2-dependent pathway in rat cardiac fibroblasts
    Bai Lei
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Japan
    J Pharmacol Sci 117:98-105. 2011
    ..These data suggest that efonidipine elicits inhibitory effects on TGF-β1- and Smad2-dependent protein synthesis through both T-type and L-type calcium channel-blocking actions in cardiac fibroblasts...
  62. ncbi request reprint RAS inhibition attenuates cognitive impairment by reducing blood- brain barrier permeability in hypertensive subjects
    Nicolas Pelisch
    Department of Pharmacology, Kagawa University Medical School, Kagawa 761 0793, Japan
    Curr Hypertens Rev 9:93-8. 2013
    ..These data support the hypothesis that RAS inhibition attenuates cognitive impairment by reducing BBB injury, which is independent of blood pressure changes. ..
  63. pmc Short-Term Calorie Restriction in Early Life Attenuates the Development of Proteinuria but Not Glucose Intolerance in Type 2 Diabetic OLETF Rats
    Daisuke Nakano
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    ISRN Endocrinol 2011:768637. 2011
    ..In contrast, short-term high-calorie intake or CR at a young age does not appear to affect glucose metabolism in later life...
  64. ncbi request reprint Molecular mechanism underlying the detection of colorectal cancer by 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography
    Kunihiko Izuishi
    Department of Gastroenterological Surgery, Kagawa University, 1750 11, Ikenobe, Miki, Kita, Takamatsu, Kagawa, 761 0793, Japan
    J Gastrointest Surg 16:394-400. 2012
    ..In this study, we examined the molecular mechanism underlying the detection of colorectal cancers by FDG-PET...
  65. doi request reprint The ratio of insulin-like growth factor-I/insulin-like growth factor-binding protein-3 in sera of patients with hepatitis C virus-related chronic liver disease as a predictive marker of insulin resistance
    Takashi Himoto
    Department of Integrated Medicine, Kagawa University School of Medicine, Kagawa, Japan
    Nutr Res 33:27-33. 2013
    ..411, P = .0094). These findings suggest that the decline of the circulating free IGF-I level, which derives from zinc deficiency, may contribute to hepatic steatosis and insulin resistance in patients with HCV-related CLD...
  66. doi request reprint The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo
    Kiyohito Kato
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Mol Cancer Ther 11:549-60. 2012
    ..The miRNA expression was markedly altered with the treatment of metformin in vitro and in vivo. Various miRNAs altered by metformin also may contribute to tumor growth in vitro and in vivo...
  67. ncbi request reprint Aldosterone induces vascular insulin resistance by increasing insulin-like growth factor-1 receptor and hybrid receptor
    Shamshad J Sherajee
    Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Arterioscler Thromb Vasc Biol 32:257-63. 2012
    ....
  68. doi request reprint Mechanical stretch augments insulin-induced vascular smooth muscle cell proliferation by insulin-like growth factor-1 receptor
    Gang Liu
    Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Exp Cell Res 317:2420-8. 2011
    ..These results provide a basis for clarifying the molecular mechanisms of vascular remodeling in hypertensive patients with hyperinsulinemia...