Nobuyuki Kawai

Summary

Affiliation: Kagawa University
Country: Japan

Publications

  1. doi request reprint Cerebral blood flow and oxygen metabolism measurements using positron emission tomography on the first day after carotid artery stenting
    Nobuyuki Kawai
    Department of Neurological Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan Electronic address
    J Stroke Cerebrovasc Dis 23:e55-64. 2014
  2. pmc 18F-FDG PET in the diagnosis and treatment of primary central nervous system lymphoma
    Nobuyuki Kawai
    Department of Neurological Surgery, Faculty of Medicine, Kagawa University, Kita gun, Kagawa, Japan
    Biomed Res Int 2013:247152. 2013
  3. doi request reprint Detection of brain amyloid β deposition in patients with neuropsychological impairment after traumatic brain injury: PET evaluation using Pittsburgh Compound-B
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University, Faculty of Medicine, 1750 1 Miki cho, Kita gun, Kagawa, Japan
    Brain Inj 27:1026-31. 2013
  4. pmc Cerebral blood flow and metabolism measurement using positron emission tomography before and during internal carotid artery test occlusions: feasibility of rapid quantitative measurement of CBF and OEF/CMRO(2)
    N Kawai
    Department of Neurological Surgery, Kagawa University, Kagawa, Japan
    Interv Neuroradiol 18:264-74. 2012
  5. ncbi request reprint Magnetic resonance imaging and positron emission tomography findings in status epilepticus following severe hypoglycemia
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University School of Medicine, Japan
    Ann Nucl Med 20:371-6. 2006
  6. ncbi request reprint FDG-PET findings of the brain in lymphomatoid granulomatosis
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University School of Medicine, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    Ann Nucl Med 20:683-7. 2006
  7. doi request reprint Targeting optimal biopsy location in basal ganglia germinoma using (11)C-methionine positron emission tomography
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University School of Medicine, Kita gun, Kagawa 761 0793, Japan
    Surg Neurol 70:408-13; discussion 413. 2008
  8. ncbi request reprint Regional cerebral blood flow and oxygen metabolism in aneurysmal subarachnoid hemorrhage: positron emission tomography evaluation of clipping versus coiling
    N Kawai
    Department of Neurological Surgery, Kagawa University School of Medicine, Kagawa, Japan
    Acta Neurochir Suppl 105:211-5. 2008
  9. doi request reprint Use of PET in the diagnosis of primary CNS lymphoma in patients with atypical MR findings
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University, Faculty of Medicine, 1750 1 Miki cho, Kita gun, Kagawa, 761 0793, Japan
    Ann Nucl Med 24:335-43. 2010
  10. ncbi request reprint Metabolic disturbance without brain ischemia in traumatic brain injury: a positron emission tomography study
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University School of Medicine, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    Acta Neurochir Suppl 102:241-5. 2008

Collaborators

Detail Information

Publications64

  1. doi request reprint Cerebral blood flow and oxygen metabolism measurements using positron emission tomography on the first day after carotid artery stenting
    Nobuyuki Kawai
    Department of Neurological Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan Electronic address
    J Stroke Cerebrovasc Dis 23:e55-64. 2014
    ....
  2. pmc 18F-FDG PET in the diagnosis and treatment of primary central nervous system lymphoma
    Nobuyuki Kawai
    Department of Neurological Surgery, Faculty of Medicine, Kagawa University, Kita gun, Kagawa, Japan
    Biomed Res Int 2013:247152. 2013
    ..In conclusion, (18)F-FDG PET is very useful in the diagnosis of typical PCNSL and can differentiate PCNSL from other malignant brain tumors. However, the usefulness of (18)F-FDG PET is limited in the diagnosis of atypical PCNSL. ..
  3. doi request reprint Detection of brain amyloid β deposition in patients with neuropsychological impairment after traumatic brain injury: PET evaluation using Pittsburgh Compound-B
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University, Faculty of Medicine, 1750 1 Miki cho, Kita gun, Kagawa, Japan
    Brain Inj 27:1026-31. 2013
    ..This study was conducted to detect cerebral Aβ deposition using amyloid positron emission tomography (PET) in patients with neuropsychological impairment after TBI...
  4. pmc Cerebral blood flow and metabolism measurement using positron emission tomography before and during internal carotid artery test occlusions: feasibility of rapid quantitative measurement of CBF and OEF/CMRO(2)
    N Kawai
    Department of Neurological Surgery, Kagawa University, Kagawa, Japan
    Interv Neuroradiol 18:264-74. 2012
    ..Measurement of the CBF and OEF/CMRO(2) using a rapid PET protocol before and during BTO is feasible and can be used for accurate assessment of tolerance prediction in ICA occlusion...
  5. ncbi request reprint Magnetic resonance imaging and positron emission tomography findings in status epilepticus following severe hypoglycemia
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University School of Medicine, Japan
    Ann Nucl Med 20:371-6. 2006
    ..Simultaneous examination of the cerebral blood flow and metabolism using PET can provide useful information about the pathology in patients with status epilepticus...
  6. ncbi request reprint FDG-PET findings of the brain in lymphomatoid granulomatosis
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University School of Medicine, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    Ann Nucl Med 20:683-7. 2006
    ..18F]FDG-PET study with kinetic analysis may be useful to diagnose LYG in the central nervous system...
  7. doi request reprint Targeting optimal biopsy location in basal ganglia germinoma using (11)C-methionine positron emission tomography
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University School of Medicine, Kita gun, Kagawa 761 0793, Japan
    Surg Neurol 70:408-13; discussion 413. 2008
    ..The usefulness of MET-PET in locating an optimal biopsy target and monitoring treatment efficacy in this case is presented...
  8. ncbi request reprint Regional cerebral blood flow and oxygen metabolism in aneurysmal subarachnoid hemorrhage: positron emission tomography evaluation of clipping versus coiling
    N Kawai
    Department of Neurological Surgery, Kagawa University School of Medicine, Kagawa, Japan
    Acta Neurochir Suppl 105:211-5. 2008
    ....
  9. doi request reprint Use of PET in the diagnosis of primary CNS lymphoma in patients with atypical MR findings
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University, Faculty of Medicine, 1750 1 Miki cho, Kita gun, Kagawa, 761 0793, Japan
    Ann Nucl Med 24:335-43. 2010
    ....
  10. ncbi request reprint Metabolic disturbance without brain ischemia in traumatic brain injury: a positron emission tomography study
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University School of Medicine, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    Acta Neurochir Suppl 102:241-5. 2008
    ..Cerebral ischemia is believed to be an important mechanism of secondary neuronal injury in traumatic brain injury (TBI)...
  11. doi request reprint Correlation of biological aggressiveness assessed by 11C-methionine PET and hypoxic burden assessed by 18F-fluoromisonidazole PET in newly diagnosed glioblastoma
    Nobuyuki Kawai
    Department of Neurological Surgery, Faculty of Medicine, Kagawa University, Kita gun, Kagawa, Japan
    Eur J Nucl Med Mol Imaging 38:441-50. 2011
    ....
  12. doi request reprint Use of 11C-methionine positron emission tomography in basal germinoma: assessment of treatment response and residual tumor
    Nobuyuki Kawai
    Department of Neurological Surgery, Faculty of Medicine, Kagawa University, 1750 1 Miki cho, Kita gun, Kagawa, 761 0793, Japan
    Childs Nerv Syst 25:845-53. 2009
    ..PET STUDIES: The usefulness of (11)C-methionine (MET) positron emission tomography (PET) in monitoring the biological nature of brain tumors has been proved in glioma patients...
  13. doi request reprint Prognostic value of pretreatment 18F-FDG PET in patients with primary central nervous system lymphoma: SUV-based assessment
    Nobuyuki Kawai
    Department of Neurological Surgery, Faculty of Medicine, Kagawa University, Kita gun, Kagawa, Japan
    J Neurooncol 100:225-32. 2010
    ..The survival time tended to be longer in patients with high MVD than in low MVD, but the difference was not statistically significant (P = 0.15). Pretreatment FDG uptake may have a prognostic value in newly diagnosed PCNSL...
  14. ncbi request reprint Evaluation of tumor FDG transport and metabolism in primary central nervous system lymphoma using [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) kinetic analysis
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University School of Medicine, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    Ann Nucl Med 19:685-90. 2005
    ..The aim of this study was to evaluate the feasibility of FDG-PET kinetic analysis in measurement of uptake parameters of FDG in the lymphoma tissues and in the assessment of treatment effects in patients with PCNSL...
  15. pmc Relation of LAT1/4F2hc expression with pathological grade, proliferation and angiogenesis in human gliomas
    Zhen Haining
    Department of Neurological Surgery, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    BMC Clin Pathol 12:4. 2012
    ..abstract:..
  16. doi request reprint 3'-Deoxy-3'-[(18)F]-fluorothymidine ([(18)F]-FLT) transport in newly diagnosed glioma: correlation with nucleoside transporter expression, vascularization, and blood-brain barrier permeability
    Aya Shinomiya
    Department of Neurological Surgery, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Miki, Kagawa, 761 0173, Japan
    Brain Tumor Pathol 30:215-23. 2013
    ..This preliminary study suggests that ENT1 expression might not reflect accumulation of [(18)F]-FLT in vivo due to BBB permeability in glioma...
  17. ncbi request reprint Usefulness of [18F]FDG-PET kinetic analysis in non-enhancing primary central nervous system lymphoma: case report
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University School of Medicine, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    Ann Nucl Med 19:415-9. 2005
    ..Kinetic [18F]FDG-PET analysis may be useful to diagnose and monitor the treatment effect in non-enhancing primary central nervous system lymphoma...
  18. doi request reprint Evaluation of 3'-deoxy-3'-[18F]-fluorothymidine (18F-FLT) kinetics correlated with thymidine kinase-1 expression and cell proliferation in newly diagnosed gliomas
    Aya Shinomiya
    Department of Neurological Surgery, Kagawa University Faculty of Medicine, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    Eur J Nucl Med Mol Imaging 40:175-85. 2013
    ....
  19. ncbi request reprint Neural stem cells transplantation in cortex in a mouse model of Alzheimer's disease
    Qinghua Wang
    Department of Neurological Surgery, Faculty of Medicine, Kagawa University, Kita gun, Japan
    J Med Invest 53:61-9. 2006
    ..The goal of this study was to elucidate the effect of neurospheres (NS) on dementia in the mouse model of nucleus basalis of Meynert (NBM) lesion...
  20. pmc Usefulness of FDG, MET and FLT-PET studies for the management of human gliomas
    Keisuke Miyake
    Department of Neurological Surgery, Faculty of Medicine, Kagawa University, Kita gun, Kagawa, Japan
    J Biomed Biotechnol 2012:205818. 2012
    ..PET imaging is a noninvasive modality that is useful in determining a tumor area for removal as well as improving preoperative diagnosis for gliomas...
  21. ncbi request reprint [Usefulness of FDG-PET in monitoring effects of the modality therapy for central nervous system malignant lymphoma: report of three cases]
    Tetsuya Masada
    Department of Neurological Surgery, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki chou, Kida gun, Kagawa 761 0793, Japan
    No Shinkei Geka 32:859-64. 2004
    ..FDG-PET was useful in monitoring the therapeutic effects of malignant lymphoma. These results indicate that we were able to confirm the effectiveness of the therapy in the early stage...
  22. ncbi request reprint Cerebral metabolism monitoring during hypothermia following resuscitation from cardiopulmonary arrest
    Takehiro Nakamura
    Department of Neurobiology, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki, Kita, Kagawa 761 0173, Japan
    Acta Neurochir Suppl 102:203-6. 2008
    ..The aim of the present study was to evaluate cerebral metabolism monitoring during therapeutic hypothermia for global ischemic brain damage after cardiopulmonary resuscitation (CPR)...
  23. ncbi request reprint Seizure suppression in amygdala-kindled mice by transplantation of neural stem/progenitor cells derived from mouse embryonic stem cells
    Atsushi Shindo
    Department of Neurological Surgery, Kagawa University Faculty of Medicine, Kagawa
    Neurol Med Chir (Tokyo) 50:98-105; disucussion 105-6. 2010
    ..NS/PCs derived from ES cells have high potential for use in transplantation therapy for clinically intractable epilepsies...
  24. doi request reprint Serine protease inhibitor attenuates intracerebral hemorrhage-induced brain injury and edema formation in rat
    Takehiro Nakamura
    Department of Neurobiology and Neurological Surgery, Kagawa University Faculty of Medicine, Kita, Kagawa, Japan
    Acta Neurochir Suppl 106:307-10. 2010
    ..FUT did not increase collagenase-induced hematoma volume. FUT attenuates ICH-induced brain edema and DNA injury suggesting that serine protease inhibitor may be potential therapeutic agent for ICH...
  25. ncbi request reprint Usefulness of L-[methyl-11c]methionine positron emission tomography in the treatment of idiopathic hypertrophic cranial pachymeningitis--case report
    Keisuke Miyake
    Department of Neurological Surgery, Kagawa University Faculty of Medicine, Kita, Kagawa, Japan
    Neurol Med Chir (Tokyo) 52:765-9. 2012
    ....
  26. doi request reprint Anti-oxidative effects of d-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat
    Takehiro Nakamura
    Department of Neurobiology, Kagawa University Faculty of Medicine, Miki, Kita, Kagawa, Japan
    Neurosci Lett 487:103-6. 2011
    ..The number of AP-sites and 8-OHdG levels were also reduced by D-allose. Thus, the present study suggests that D-allose has anti-oxidative effects and induces neuroprotection in focal cerebral ischemia...
  27. ncbi request reprint Diagnostic value of kinetic analysis using dynamic FDG PET in immunocompetent patients with primary CNS lymphoma
    Yoshihiro Nishiyama
    Department of Radiology, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    Eur J Nucl Med Mol Imaging 34:78-86. 2007
    ....
  28. doi request reprint 11C-methionine (MET) and 18F-fluorothymidine (FLT) PET in patients with newly diagnosed glioma
    Tetsuhiro Hatakeyama
    Department of Neurological Surgery, Kagawa University School of Medicine, 1750 1 Miki cho, Kita gun, Kagawa, 761 0793, Japan
    Eur J Nucl Med Mol Imaging 35:2009-17. 2008
    ....
  29. doi request reprint Diagnostic value of kinetic analysis using dynamic 18F-FDG-PET in patients with malignant primary brain tumor
    Naruhide Kimura
    Department of Radiology, Faculty of Medicine, Kagawa University, Kita gun, Kagawa, Japan
    Nucl Med Commun 30:602-9. 2009
    ....
  30. ncbi request reprint [Usefulness and limitation of FDG-PET in the diagnosis of primary central nervous system lymphoma]
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University, Japan
    No Shinkei Geka 41:117-26. 2013
    ..However, the role of FDG-PET is limited in the diagnosis of atypical PCNSL, but dynamic analysis of FDG-PET may overcome this issue...
  31. doi request reprint Correlation of 18F-FLT uptake with tumor grade and Ki-67 immunohistochemistry in patients with newly diagnosed and recurrent gliomas
    Yuka Yamamoto
    Department of Radiology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    J Nucl Med 53:1911-5. 2012
    ..We evaluated 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) uptake in patients with newly diagnosed and recurrent gliomas and correlated the results with tumor grade and proliferative activity...
  32. doi request reprint Comparison of 11C-methionine PET and 18F-FDG PET in patients with primary central nervous system lymphoma
    Yoshiro Kawase
    Department of Radiology, Faculty of Medicine, Kagawa University, Kita gun, Kagawa, Japan
    Mol Imaging Biol 13:1284-9. 2011
    ..Although (11)C-methionine (MET) PET has been reported to be useful for evaluating various brain tumors, the role of MET PET in CNS lymphoma is unclear. We compared the uptake of MET and FDG in patients with CNS lymphoma...
  33. ncbi request reprint [Case of metastatic malignant melanoma detected by multifocal cerebral hemorrhage]
    Aya Shinomiya
    Department of Neurological Surgery, Kagawa University, Kagawa, Japan
    No Shinkei Geka 40:261-9. 2012
    ..We think that the development of a therapeutic strategy for the treatment of intracranial metastatic malignant melanoma, including its risk management of intracerebral hemorrhage would be great importance...
  34. ncbi request reprint [11C-methionine positron emission tomography in nontumorous brain lesions]
    Nobuyuki Kawai
    Department of Neurological Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan
    No Shinkei Geka 38:985-95. 2010
    ..Although differentiation from tumorous lesions is usually possible by laboratory and morphological examinations, nontumorous lesions should be included in the differential diagnosis when encountering patients with high MET uptake...
  35. doi request reprint Focal neuronal damage in patients with neuropsychological impairment after diffuse traumatic brain injury: evaluation using ¹¹C-flumazenil positron emission tomography with statistical image analysis
    Nobuyuki Kawai
    Department of Neurological Surgery, Faculty of Medicine, Kagawa University, Miki cho, Japan
    J Neurotrauma 27:2131-8. 2010
    ..Future studies to confirm a common area of focal neuronal damage and a direct correlation with neuropsychological testing may validate the use of FMZ-PET for the functional diagnosis of neuropsychological impairments after TBI...
  36. doi request reprint Hypoxia assessed by 18F-fluoromisonidazole positron emission tomography in newly diagnosed gliomas
    Yuka Yamamoto
    Department of Clinical Radiology, Kagawa University Hospital, Kagawa, Japan
    Nucl Med Commun 33:621-5. 2012
    ..The aim of this study was to evaluate the degree of hypoxia in newly diagnosed gliomas using 18F-fluoromisonidazole (FMISO) PET and to compare the results with tumor grade...
  37. doi request reprint Correlation of L-methyl-11C-methionine (MET) uptake with L-type amino acid transporter 1 in human gliomas
    Shuichi Okubo
    Department of Neurological Surgery, Faculty of Medicine, Kagawa University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    J Neurooncol 99:217-25. 2010
    ..Use of MET-PET as a molecular target combined with anti-angiogenesis in glioma therapy should be addressed in future studies...
  38. ncbi request reprint [Use of 11F-fluorothymidine positron emission tomography in brain tumor]
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University School of Medicine, Japan
    No Shinkei Geka 37:657-64. 2009
    ..Increased FLT accumulation is also observed in other brain tumors including malignant lymphoma and metastatic brain tumor. Further studies are necessary to validate the usefulness of FLT-PET in brain tumor diagnosis and treatment...
  39. doi request reprint Relapse of herpes encephalitis induced by temozolomide-based chemoradiation in a patient with malignant glioma
    Masaki Okada
    Department of Neurological Surgery, Kagawa University Faculty of Medicine, Kagawa, Japan
    J Neurosurg 118:258-63. 2013
    ..Antiviral therapy for HSE must be initiated immediately, and the chemoradiation for glioma should be stopped; however, it is not clear what antitumor therapy is optimal when HSE co-occurs during the treatment of glioma...
  40. doi request reprint Shortening the duration of [18F]FDG PET brain examination for diagnosis of brain glioma
    Toshihide Monden
    Department of Clinical Radiology, Kagawa University Hospital, Miki cho, Kita gun, Kagawa, Japan
    Mol Imaging Biol 13:754-8. 2011
    ..We investigated the change of the parametric values when the time duration of PET data was shortened...
  41. ncbi request reprint Crossed cerebellar glucose hypermetabolism demonstrated using PET in symptomatic epilepsy--case report
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University School of Medicine, Japan
    Ann Nucl Med 19:231-4. 2005
    ....
  42. doi request reprint Omission of [(15)O]CO scan for PET CMRO(2) examination using (15)O-labelled compounds
    Yasuhiro Sasakawa
    Department of Clinical Radiology, Kagawa University Hospital, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    Ann Nucl Med 25:189-96. 2011
    ..To reduce the time of scan, one possibility is to omit the use of CBV data. The present study investigated the influence of fixing the CBV to OEF and CMRO(2) values on subjects with and without cerebrovascular disorders...
  43. ncbi request reprint [Use of intracerebral microdialysis in severe traumatic brain injury]
    Nobuyuki Kawai
    Department of Neurological Surgery, Faculty of Medicine, Kagawa University, Miki cho, Kita gun, Kagawa, Japan
    No Shinkei Geka 38:795-809. 2010
    ..However, the value of MD as a tool in routine neurointensive care decision-making remains unclear...
  44. doi request reprint Effect of delayed mild brain hypothermia on edema formation after intracerebral hemorrhage in rats
    Masahiko Kawanishi
    Department of Neurological Surgery, Kagawa University School of Medicine, Kagawa, Japan
    J Stroke Cerebrovasc Dis 17:187-95. 2008
    ..Several neuroprotective mechanisms, including reduced BBB disruption, inflammation and oxidative damage, are suggested in this study...
  45. doi request reprint Unexpected finding of cerebral meningioma on (11)C-PiB PET
    Yuka Yamamoto
    Department of Radiology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Clin Nucl Med 38:292-3. 2013
    ..MR images demonstrated an extra-axial left frontal mass lesion with mild enhancement, highly suggestive of meningioma. There is a limited amount of published information on the detection of meningioma with C-PiB PET...
  46. pmc Imaging of the appearance time of cerebral blood using [15O]H2O PET for the computation of correct CBF
    Nobuyuki Kudomi
    Department of Medical Physics, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    EJNMMI Res 3:41. 2013
    ..We estimated brain ATB in an image-based fashion to correct CBF by accounting for differences in computed CBF values using three different analyses: ARG and BFM with and without fixing the partition coefficient...
  47. ncbi request reprint Hemodynamic and metabolic changes in a patient with cerebral venous sinus thrombosis: evaluation using O-15 positron emission tomography
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University School of Medicine, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    Clin Nucl Med 30:391-4. 2005
    ..PET evaluation of the cerebral hemodynamics and oxygen metabolism may be of value in gaining further insight into pathophysiological characteristics of human cerebral venous sinus thrombosis...
  48. ncbi request reprint Hyperbaric oxygen therapy for consciousness disturbance following head injury in subacute phase
    Takehiro Nakamura
    Department of Neurobiology, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki, Kita, Kagawa 761 0173, Japan
    Acta Neurochir Suppl 102:21-4. 2008
    ..The purpose of the present study was to investigate the effect of hyperbaric oxygen (HBO) therapy on the cerebral circulation and metabolism of patients with disturbances in consciousness after head injury in the subacute phase...
  49. ncbi request reprint Matrix metalloproteinase 2 and 9 expression correlated with cavernous sinus invasion of pituitary adenomas
    Weiping Liu
    Department of Neurological Surgery, Faculty of Medicine, Kagawa Medical University, Miki cho, Kita gun, Kagawa 761 0793, Japan
    J Med Invest 52:151-8. 2005
    ..The aim of this study is to evaluate the relationship between the expression of MMP-2, MMP-9, MIB-1 LI and cavernous sinus invasion in pituitary adenomas...
  50. ncbi request reprint Chiari I malformation accompanied by assimilation of the atlas, Klippel-Feil syndrome, and syringomyelia: case report
    Masahiro Kagawa
    Department of Neurological Surgery, Kagawa University, Miki cho, Kagawa, 761 0793, Japan
    Surg Neurol 65:497-502; discussion 502. 2006
    ..We report a case of Chiari I malformation accompanied by assimilation of the atlas, Klippel-Feil syndrome, and syringomyelia...
  51. doi request reprint 3CB2, a marker of radial glia, expression after experimental intracerebral hemorrhage: role of thrombin
    Takehiro Nakamura
    Department of Neurobiology, Kagawa University Faculty of Medicine, Kagawa, Japan
    Brain Res 1226:156-62. 2008
    ..Thrombin has a role in 3CB2 expression in ICH...
  52. ncbi request reprint [Usefulness of intravascular ultrasound in embolization of dural arteriovenous fistula: a case report]
    Atsushi Shindo
    Department of Neurological Surgery, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kida gun, Kagawa 761 0793, Japan
    No Shinkei Geka 31:1323-9. 2003
    ..Eight months after treatment, PET study showed some normalization of rOEF and rCMRO2 of the left occipital lobe with the clinical symptom. IVUS is useful in determining the exact sites of transvenous embolization of DAVF...
  53. ncbi request reprint Effects of mild hypothermia and alkalizing agents on brain injuries in rats with acute subdural hematomas
    Masanobu Okauchi
    Department of Neurological Surgery, Kagawa Medical University, Kagawa, Japan
    J Neurotrauma 19:741-51. 2002
    ..The protection of the BBB is one of the possible cerebroprotective mechanisms in this rat acute SDH model...
  54. doi request reprint Relationship of 14-3-3zeta (ζ), HIF-1α, and VEGF expression in human brain gliomas
    Wei dong Cao
    Department of Neurological Surgery, Faculty of Medicine, Kagawa University, 1750 1, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    Brain Tumor Pathol 31:1-10. 2014
    ..Further studies will elucidate their detailed role in the malignant progression of glioma, and will contribute to the development of a new treatment strategy for this lethal disease. ..
  55. ncbi request reprint Anti-inflammatory effect of D-allose in cerebral ischemia/reperfusion injury in rats
    Dakuan Gao
    Department of Neurological Surgery, Kagawa University Faculty of Medicine, Japan
    Neurol Med Chir (Tokyo) 53:365-74. 2013
    ..Treatment with D-allose might provide a new strategy and clinically beneficial outcome for acute ischemic stroke. ..
  56. ncbi request reprint [Brain hypothermia for ischemic brain damage]
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa Medical University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    No Shinkei Geka 30:1273-83. 2002
  57. ncbi request reprint Hypertrophic Cranial Pachymeningitis With IgG4-Positive Plasma Cells Detected by C-11 Methionine PET
    Takashi Norikane
    From the Departments of Radiology and Neurological Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Clin Nucl Med 37:108-9. 2012
    ..After steroid therapy, he became asymptomatic, and a follow-up PET scan showed disappearance of the peripheral brain uptake of MET...
  58. ncbi request reprint Differences in the neuronal stem cells survival, neuronal differentiation and neurological improvement after transplantation of neural stem cells between mild and severe experimental traumatic brain injury
    Tokuhisa Shindo
    Department of Neurological Surgery, Faculty of Medicine, Kagawa University, Kita gun, Japan
    J Med Invest 53:42-51. 2006
    ..The data also revealed significant differences between the mild TBI and normal groups. The transplanted neurospheres could survive in the mild TBI animals, but not in the severe TBI group...
  59. ncbi request reprint Matrix metalloproteinase-2 and matrix metalloproteinase-9 expressions correlate with the recurrence of intracranial meningiomas
    Masaki Okada
    Department of Neurological Surgery, Kagawa Medical University, Kita County, Kagawa, Japan
    J Neurooncol 66:29-37. 2004
    ..We studied whether or not the expressions of MMP-2 and MMP-9 were correlated with the proliferative potential or recurrence of intracranial meningiomas...
  60. ncbi request reprint Treatment of cold injury-induced brain edema with a nonspecific matrix metalloproteinase inhibitor MMI270 in rats
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa Medical University, Kagawa, Japan
    J Neurotrauma 20:649-57. 2003
    ..05) a 7 days after the cold injury. O kur results indicate that treatment with MMI270 in rats exhibits protection in acute brain edema formation and secondary brain damage by attenuating the BBB permeability after cold injury...
  61. doi request reprint The anti-inflammatory effects of D-allose contribute to attenuation of cerebral ischemia-reperfusion injury
    Dakuan Gao
    Department of Neurological Surgery, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kagawa 761 0793, Japan
    Med Hypotheses 76:911-3. 2011
    ..However, inflammatory responses play an important role in the mechanisms of cerebral I/R injury. So we hypothesize that D-allose might perform neuroprotection against cerebral ischemia-reperfusion injury by its anti-inflammatory effects...
  62. pmc Xanthogranuloma of the intrasellar region presenting in pituitary dysfunction: a case report
    Takamasa Nishiuchi
    Division of Hematology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750 1, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    J Med Case Rep 6:119. 2012
    ..abstract:..
  63. ncbi request reprint [Pathophysiology of brain edema formation following stroke: recent advancement]
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University School of Medicine
    Nihon Rinsho 64:122-6. 2006