Yoshiyuki Kakehi

Summary

Affiliation: Kagawa University
Country: Japan

Publications

  1. ncbi request reprint [Quality of life after radical prostatectomy]
    Yoshihiro Kuwata
    Department of Urology, Faculty of Medicine, Kagawa University
    Nihon Rinsho 63:315-20. 2005
  2. doi request reprint Bladder Cancer Working Group report
    Yoshiyuki Kakehi
    Department of Urology, Kagawa University, Faculty of Medicine, 1750 1 Oaza Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Jpn J Clin Oncol 40:i57-64. 2010
  3. pmc Renal Cell Carcinoma with IVC Thrombi; Current Concepts and Future Perspectives
    Mohammed Ahmed Abdel Muneem Nouh
    Department of Urology, Kagawa University, Faculty of Medicine, Kagawa, Japan
    Clin Med Oncol 2:247-56. 2008
  4. pmc Life-threatening gastrointestinal bleeding during targeted therapy for advanced renal cell carcinoma: a case report
    Shintaro Fujihara
    Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine Graduate School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa prefecture 761 0793, Japan
    BMC Nephrol 14:141. 2013
  5. pmc Expression and Role of GPR87 in Urothelial Carcinoma of the Bladder
    Homare Okazoe
    Department of Urology, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Mol Sci 14:12367-79. 2013
  6. pmc Active surveillance as a practical strategy to differentiate lethal and non-lethal prostate cancer subtypes
    Yoshiyuki Kakehi
    Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan
    Asian J Androl 14:361-4. 2012
  7. ncbi request reprint Health related quality of life in Japanese men with localized prostate cancer treated with current multiple modalities assessed by a newly developed Japanese version of the Expanded Prostate Cancer Index Composite
    Yoshiyuki Kakehi
    Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan
    J Urol 177:1856-61. 2007
  8. doi request reprint Prospective evaluation of selection criteria for active surveillance in Japanese patients with stage T1cN0M0 prostate cancer
    Yoshiyuki Kakehi
    Department of Urology, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Jpn J Clin Oncol 38:122-8. 2008
  9. doi request reprint Complication rates of ultrasound-guided prostate biopsy: a nation-wide survey in Japan
    Yoshiyuki Kakehi
    Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan
    Int J Urol 15:319-21. 2008
  10. doi request reprint The phytotherapeutic agent, eviprostat, suppresses stromal proliferation and inflammation even after establishment of nonbacterial prostatitis in the rat prostate
    Shinsuke Shibuya
    Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Urology 83:528-34. 2014

Detail Information

Publications94

  1. ncbi request reprint [Quality of life after radical prostatectomy]
    Yoshihiro Kuwata
    Department of Urology, Faculty of Medicine, Kagawa University
    Nihon Rinsho 63:315-20. 2005
    ..Recently several authors have reported that HRQOL were affected with ethnic and cultural differences. These results strongly suggested a need for longitudinal surveys in Japanese patients...
  2. doi request reprint Bladder Cancer Working Group report
    Yoshiyuki Kakehi
    Department of Urology, Kagawa University, Faculty of Medicine, 1750 1 Oaza Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Jpn J Clin Oncol 40:i57-64. 2010
    ..Further studies are needed to confirm potential gene-gene and gene-environmental interactions leading to bladder carcinogenesis...
  3. pmc Renal Cell Carcinoma with IVC Thrombi; Current Concepts and Future Perspectives
    Mohammed Ahmed Abdel Muneem Nouh
    Department of Urology, Kagawa University, Faculty of Medicine, Kagawa, Japan
    Clin Med Oncol 2:247-56. 2008
    ..Also, we are providing our suggestion regarding the use of angioscopy for removal of IVC thrombi in a relatively bloodless field without aggressive surgical manipulations or shunt techniques for maintenance of hemodynamic stability...
  4. pmc Life-threatening gastrointestinal bleeding during targeted therapy for advanced renal cell carcinoma: a case report
    Shintaro Fujihara
    Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine Graduate School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa prefecture 761 0793, Japan
    BMC Nephrol 14:141. 2013
    ..This is the first case report of such an adverse drug reaction in the literature...
  5. pmc Expression and Role of GPR87 in Urothelial Carcinoma of the Bladder
    Homare Okazoe
    Department of Urology, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Mol Sci 14:12367-79. 2013
    ..056). These results warrant further prospective studies to clarify the role of GPR87 expression in intravesical recurrence and progression in bladder cancer...
  6. pmc Active surveillance as a practical strategy to differentiate lethal and non-lethal prostate cancer subtypes
    Yoshiyuki Kakehi
    Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan
    Asian J Androl 14:361-4. 2012
    ..In this review, the benefits and risks of active surveillance are discussed. Future perspectives, including imaging and new biomarkers for improving the outcomes of active surveillance programs, are also discussed...
  7. ncbi request reprint Health related quality of life in Japanese men with localized prostate cancer treated with current multiple modalities assessed by a newly developed Japanese version of the Expanded Prostate Cancer Index Composite
    Yoshiyuki Kakehi
    Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan
    J Urol 177:1856-61. 2007
    ..We evaluated psychometric properties of the Japanese version of the Extended Prostate Cancer Index Composite...
  8. doi request reprint Prospective evaluation of selection criteria for active surveillance in Japanese patients with stage T1cN0M0 prostate cancer
    Yoshiyuki Kakehi
    Department of Urology, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Jpn J Clin Oncol 38:122-8. 2008
    ..Selection criteria for active surveillance (AS) program of localized prostate cancer remain to be standardized. The purpose was to evaluate the validity of selection criteria and investigate the feasibility of this AS program...
  9. doi request reprint Complication rates of ultrasound-guided prostate biopsy: a nation-wide survey in Japan
    Yoshiyuki Kakehi
    Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan
    Int J Urol 15:319-21. 2008
    ..To assess the morbidity secondary to ultrasound-guided systematic prostate biopsy in Japan...
  10. doi request reprint The phytotherapeutic agent, eviprostat, suppresses stromal proliferation and inflammation even after establishment of nonbacterial prostatitis in the rat prostate
    Shinsuke Shibuya
    Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Urology 83:528-34. 2014
    ....
  11. doi request reprint Gene expression profiles of lysophosphatidic acid-related molecules in the prostate: relevance to prostate cancer and benign hyperplasia
    Yu Zeng
    Department of Urology, Kagawa University Faculty of Medicine, Kita gun, Kagawa, Japan
    Prostate 69:283-92. 2009
    ..To elucidate gene expression profiles of lysophosphatidic acid (LPA)-related molecules in cancer, pre-cancerous lesion, and benign hyperplasia of the prostate...
  12. doi request reprint Excess fluid distribution affects tacrolimus absorption in peritoneal dialysis patients
    Tadashi Sofue
    Division of Nephrology and Dialysis, Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    Clin Exp Nephrol 17:743-9. 2013
    ..The purpose of this study was to evaluate the relationship between tacrolimus pharmacokinetics and excess fluid distribution according to pre-transplant dialysis modality...
  13. doi request reprint Expression of autotaxin and acylglycerol kinase in prostate cancer: association with cancer development and progression
    Mohammed Ahmed Abdel Muneem Nouh
    Department of Urology, Kagawa University Faculty of Medicine, Miki cho, Kagawa, Japan
    Cancer Sci 100:1631-8. 2009
    ..In conclusion, LPA-producing enzymes (ATX and AGK) were frequently expressed in prostate cancer cells and precancerous HG-PIN. In particular, high expression levels of ATX were associated with both malignant potentials and poor outcomes...
  14. ncbi request reprint Association of a genetic polymorphism of the E-cadherin gene with prostate cancer in a Japanese population
    Toshiyuki Kamoto
    Department of Urology, Kyoto University Graduate School of Medicine, Shogoin kawahara cho 54, Sakyo ku, Kyoto City, Kyoto 606 8507, Japan
    Jpn J Clin Oncol 35:158-61. 2005
    ..93, P = 0.016). It is possible that the presence of one A allele resulted in an increased risk of cancer progression...
  15. ncbi request reprint Dissociation of sexual function and sexual bother following autologous sural nerve grafting during radical prostatectomy
    Yoshihiro Kuwata
    Department of Urology, Kagawa University, Faculty of Medicine, Kagawa, Japan
    Int J Urol 14:510-4. 2007
    ....
  16. ncbi request reprint Enhancement of TRAIL/Apo2L-mediated apoptosis by adriamycin through inducing DR4 and DR5 in renal cell carcinoma cells
    Xiu Xian Wu
    Department of Urology, Kagawa Medical University, Kagawa, Japan
    Int J Cancer 104:409-17. 2003
    ..These findings indicate that ADR sensitizes RCC cells to TRAIL/Apo2L-mediated apoptosis through induction of DR4 and DR5, suggesting that the combination therapy of TRAIL/Apo2L and ADR might be effective for RCC therapy...
  17. ncbi request reprint Short-term prognosis of living-donor kidney transplantation from hypertensive donors with high-normal albuminuria
    Tadashi Sofue
    1 Division of Nephrology and Dialysis, Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan 2 Department of Urology, Tokyo Women s Medical University, Tokyo, Japan 3 Department of Pathology, Kagawa University, Kagawa, Japan 4 Department of Urology, Kagawa University, Kagawa, Japan 5 Department of Pharmacology, Kagawa University, Kagawa, Japan 6 Address correspondence to Tadashi Sofue, M D, Ph D, Division of Nephrology and Dialysis, Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Transplantation 97:104-10. 2014
    ..Therefore, we investigated the transplant prognosis of HTDs with HNA...
  18. ncbi request reprint Analysis linking UCLA PCI with Expanded Prostate Cancer Index Composite: an evaluation of health related quality of life in Japanese men with localized prostate cancer
    Shunichi Namiki
    Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Urol 178:473-7; discussion 477. 2007
    ..We evaluated the correspondence between UCLA PCI and the Extended Prostate Cancer Index Composite for Japanese patients with localized prostate cancer...
  19. doi request reprint Misdiagnosis of two cases of primary aldosteronism owing to failure of computed tomography to detect adrenal microadenoma
    Mako Fujiwara
    Department of Internal Medicine, Kagawa University, Kagawa, Japan
    Am J Med Sci 340:335-7. 2010
    ..In conclusion, AVS should be performed to confirm the diagnosis of PA when computed tomography imaging does not provide definite results...
  20. doi request reprint Pathological findings at radical prostatectomy in Japanese prospective active surveillance cohort
    Mikio Sugimoto
    Department of Urology, Kagawa University Faculty of Medicine, Kita gun, Kagawa 761 0793, Japan
    Jpn J Clin Oncol 40:973-9. 2010
    ..The present study was carried out to analyze pathological features of prostatectomy specimens performed at different timing and trigger during active surveillance...
  21. ncbi request reprint Low concentrations of doxorubicin sensitizes human solid cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-receptor (R) 2-mediated apoptosis by inducing TRAIL-R2 expression
    Xiu Xian Wu
    Department of Urology, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Cancer Sci 98:1969-76. 2007
    ....
  22. ncbi request reprint Uroplakin II as a promising marker for molecular diagnosis of nodal metastases from bladder cancer: comparison with cytokeratin 20
    Xiuxian Wu
    Department of Urology, Faculty of Medicine, Kagawa University, 1750 1 Oaza Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    J Urol 174:2138-42, discussion 2142-3. 2005
    ..We performed a systemic study of uroplakin II (UP II) and cytokeratin 20 (CK 20) expression in pelvic lymph nodes on multiple sides in patients with bladder cancer...
  23. ncbi request reprint [Assessment of the urinary status by self-administered questionnaires in men after radical prostatectomy-- comparison with the urination status of elderly women]
    Rikiya Taoka
    The Department of Urology, Faculty of Medicine, Kagawa University
    Hinyokika Kiyo 54:717-22. 2008
    ..Consequently, careful follow-up and appropriate medical intervention are needed in men after RP as in aging women...
  24. doi request reprint Effect of the phytotherapeutic agent Eviprostat on inflammatory changes and cytokine production in a rat model of nonbacterial prostatitis
    Hiroyuki Tsunemori
    Department of Urology, Faculty of Medicine, Kagawa University, Kita gun, Kagawa, Japan
    Urology 77:1507.e15-20. 2011
    ....
  25. doi request reprint Prolonged treatment with three-weekly docetaxel plus daily prednisolone for metastatic castration-resistant prostate cancer: a multicenter, phase II, open-label, non-comparative, extension study in Japan
    Kazuo Nishimura
    Department of Urology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka, 537 8511, Japan
    Int J Clin Oncol 18:306-13. 2013
    ..Therefore, this study, ARD6563, was conducted to evaluate the safety of more than ten cycles of docetaxel in metastatic CRPC...
  26. ncbi request reprint Genetic polymorphisms of the interleukin-4 receptor alpha gene are associated with an increasing risk and a poor prognosis of sporadic renal cell carcinoma in a Japanese population
    Eijiro Nakamura
    Department of Urology, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Clin Cancer Res 8:2620-5. 2002
    ..The significance of the polymorphisms on the incidence and prognosis in sporadic RCC patients were examined to clarify the role of IL-4 as well as that of the Th1/Th2 immune system in this disease...
  27. doi request reprint Idiopathic unilateral adrenal hemorrhage in an elderly patient
    Hitomi Imachi
    Division of Hematology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Miki cho, Kita gun, 761 0793, Kagawa, Japan
    Endocrine 37:249-52. 2010
    ..It is important to distinguish this benign lesion from a neoplasm and to consider idiopathic AH in an adrenal tumor during differential diagnosis in elderly patients who have not received anticoagulation therapy or suffered from trauma...
  28. ncbi request reprint Randomized controlled trial to evaluate radiotherapy +/- endocrine therapy versus endocrine therapy alone for PSA failure after radical prostatectomy: Japan Clinical Oncology Group Study JCOG 0401
    Akira Yokomizo
    Department of Urology, Graduate School of Medical Science, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Jpn J Clin Oncol 35:34-6. 2005
    ..The Clinical Trial Review Committee of the JCOG approved the protocol on April 13, 2004, and the study was activated on May 17, 2004...
  29. pmc Efficacy and safety of febuxostat in the treatment of hyperuricemia in stable kidney transplant recipients
    Tadashi Sofue
    Division of Nephrology and Dialysis, Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University, Kagawa
    Drug Des Devel Ther 8:245-53. 2014
    ..However, its efficacy and safety in kidney recipients with PTHU is unclear. We therefore assessed the efficacy and safety of febuxostat in stable kidney transplant recipients with PTHU...
  30. doi request reprint Latent IgA deposition from donor kidneys does not affect transplant prognosis, irrespective of mesangial expansion
    Tadashi Sofue
    Division of Nephrology and Dialysis, Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Clin Transplant 27:14-21. 2013
    ..Therefore, we investigated the effects of latent IgA deposition and mesangial expansion on transplant prognosis following living-donor kidney transplantation...
  31. ncbi request reprint Low incidence of ipsilateral adrenal involvement and recurrences in patients with renal cell carcinoma undergoing radical nephrectomy: a retrospective analysis of 393 patients
    Takashi Kobayashi
    Department of Urology, Kyoto University Hospital, Kyoto, Japan
    Urology 62:40-5. 2003
    ..To evaluate, in a retrospective analysis of the outcome of 393 consecutive patients undergoing radical nephrectomy, the advantages and disadvantages of concomitant ipsilateral adrenalectomy with this operation...
  32. ncbi request reprint [Temporary inferior vena cava filter applied to 4 patients with urological disease]
    Fumio Tsukuda
    Department of Urology, Kagawa University, Faculty of Medicine
    Hinyokika Kiyo 52:561-4. 2006
    ..Temporary inferior vena cava filter is safe and useful to prevent pulmonary thromboembolism associated with urological disorders...
  33. doi request reprint Enhancement of lexatumumab-induced apoptosis in human solid cancer cells by Cisplatin in caspase-dependent manner
    Xiu Xian Wu
    Authors Affiliations Department of Urology, Faculty of Medicine, Kagawa University, Kagawa, Japan and Qiqiha Medical College, Heilongjiang, China
    Clin Cancer Res 15:2039-47. 2009
    ....
  34. pmc Outcome of different post-orchiectomy management for stage I seminoma: Japanese multi-institutional study including 425 patients
    Tomomi Kamba
    Department of Urology, Kyoto University Graduate School of Medicine Translational Research Center, Kyoto University Hospital, Kyoto, Osaka, Japan
    Int J Urol 17:980-7. 2010
    ..To clarify the contemporary clinical outcome of stage I seminoma and to provide information on treatment options to patients...
  35. ncbi request reprint Expression of a novel biomarker, EPCA, in adenocarcinomas and precancerous lesions in the prostate
    Hirotsugu Uetsuki
    Departments of Urology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    J Urol 174:514-8. 2005
    ..We clarified the relationship between EPCA expression and clinicopathological parameters, including grade and stage. Morphological characteristics of EPCA positive cells in noncancerous tissues were also analyzed...
  36. ncbi request reprint Development of Japanese version of the UCLA Prostate Cancer Index: a pilot validation study
    Yoshiyuki Kakehi
    Department of Urology, Faculty of Medicine, Kagawa Medical University, 1750 1 Ikenobe, Miki cho, Kagawa 761 0793, Japan
    Int J Clin Oncol 7:306-11. 2002
    ..The patients simultaneously responded to the Japanese version of the RAND 36-Item Health Survey (SF-36) and five representative questions from the International Index of Erectile Function (IIEF)...
  37. ncbi request reprint Sensitization of human renal cell carcinoma cell lines to TRAIL-induced apoptosis by anthracyclines
    Xiu Xian Wu
    Department of Urology, Kagawa Medical University, Kagawa Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Int J Urol 11:164-70. 2004
    ..The present study investigated whether anthracyclines enhance TRAIL-induced apoptosis and cytotoxicity in renal cell carcinoma (RCC) cells...
  38. doi request reprint Positron emission tomography with 18F-fluorodeoxyglucose is a useful tool for the diagnosis of pheochromocytomas without distant metastasis, where malignancy is suspected on the basis of histopathologic analysis
    Fumi Kikuchi
    Departments of Internal Medicine, Kagawa University, Kita gun, Japan
    Am J Med Sci 340:160-3. 2010
    ..Thus, FDG-PET may be a prognostic marker for malignant pheochromocytomas with or without metastasis...
  39. pmc The impact of baseline [-2]proPSA-related indices on the prediction of pathological reclassification at 1 year during active surveillance for low-risk prostate cancer: the Japanese multicenter study cohort
    Hiromi Hirama
    Department of Urology, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    J Cancer Res Clin Oncol 140:257-63. 2014
    ..The aim of the present study was to evaluate the predictive impact of baseline prostate-specific antigen (PSA) isoform [-2]proPSA (p2PSA)-related indices on the pathological reclassification at 1 year during an AS program...
  40. doi request reprint Cellular intermingling between adrenal gland and liver: an infrequent cause of incomplete resection at right adrenalectomy
    Mikio Sugimoto
    Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan
    J Endourol 27:804-8. 2013
    ..To assess the incidence of difficulty in complete dissection between the right adrenal gland and the liver at the time of laparoscopic surgery for adrenal tumor and to elucidate its cause histopathologically...
  41. ncbi request reprint Enhancement of death receptor 4 mediated apoptosis and cytotoxicity in renal cell carcinoma cells by subtoxic concentrations of doxorubicin
    Xinghua Jin
    Department of Urology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    J Urol 177:1894-9. 2007
    ..We investigated the effect of chemotherapeutic agents on death receptor 4 mediated apoptosis in human renal cell carcinoma cells using HGS-ETR1, which is a human monoclonal agonistic antibody specific for death receptor 4...
  42. doi request reprint Cytopathological features of warty (condylomatous) carcinoma of the penis: a case report and distinction from other verruciform penile tumors
    Toshitetsu Hayashi
    Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Diagn Cytopathol 38:841-5. 2010
    ..On the basis of the overall features, we confirmed a final diagnosis of penile WC. We demonstrated here for the first time the cytopathological features of penile WC with emphasis on differential diagnostic considerations...
  43. ncbi request reprint Cavernous nerve reconstruction during radical prostatectomy by sural nerve grafting: surgical technique in nerve harvesting and grafting
    Gan Muneuchi
    Department of Plastic and Reconstructive Surgery, Kagawa University, Kagawa, Japan
    J Reconstr Microsurg 21:525-9; discussion 530-2. 2005
    ....
  44. doi request reprint Induction of apoptosis in human renal cell carcinoma cells by vitamin E succinate in caspase-independent manner
    Xiu Xian Wu
    Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan
    Urology 73:193-9. 2009
    ..Preclinical investigations have suggested that VE succinate (VES) is the most effective analog of VE in cancer cells; however, no study of VES in RCC has been done. We investigated the anticancer activity of VES against RCC...
  45. doi request reprint Health-related quality of life in Japanese men with localized prostate cancer: assessment with the SF-8
    Mikio Sugimoto
    Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan
    Int J Urol 15:524-8. 2008
    ..To evaluate health related quality of life (HRQOL) using the Medical Outcomes Study 8-items Short Form Health Survey (SF-8) questionnaire in Japanese patients with early prostate cancer...
  46. ncbi request reprint Determination of percent area density of epithelial and stromal components in development of prostatic hyperplasia in spontaneously hypertensive rats
    Motoki Yamashita
    Department of Urology, Kagawa Medical University, Kagawa, Japan
    Urology 61:484-9. 2003
    ..To determine the percent area density of epithelial and stromal components in the development of prostatic hyperplasia in spontaneously hypertensive (SH) rats...
  47. ncbi request reprint Clinical evaluation of p53 mutations in urothelial carcinoma by IHC and FASAY
    Jun Watanabe
    Department of Urology, Kyoto University Graduate School of Medicine, Japan
    Urology 63:989-93. 2004
    ..To assess the clinical benefit of the methods of detection of p53 mutations in human urothelial carcinoma...
  48. ncbi request reprint Human agonistic antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2 induces cytotoxicity and apoptosis in prostate cancer and bladder cancer cells
    Osamu Shimada
    Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan
    Urology 69:395-401. 2007
    ..In this study, we investigated the susceptibility of human prostate cancer and bladder cancer cells to HGS-ETR2, a human monoclonal agonistic antibody specific for TRAIL-R2...
  49. ncbi request reprint Uroplakin III-delta4 messenger RNA as a promising marker to identify nonulcerative interstitial cystitis
    Yu Zeng
    Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan
    J Urol 178:1322-7; discussion 1327. 2007
    ..Uroplakins that are expressed by urothelial cells are thought to have an important role as major barrier proteins on the apical surface of the urothelium...
  50. ncbi request reprint [Three dimensional conformal radiotherapy (3D-CRT) for localized prostate cancer under field adjustment with implanted gold markers: early clinical outcome]
    Shigeo Taketa
    Department of Urology, Faculty of Medicine, Kagawa University
    Hinyokika Kiyo 50:611-6. 2004
    ..These results suggested that 3D-CRT under field adjustment with implanted gold markers contributes to both higher efficacy and lower morbidity...
  51. doi request reprint Effect of a phytotherapeutic agent, Eviprostat®, on prostatic and urinary cytokines/chemokines in a rat model of nonbacterial prostatitis
    Mikio Sugimoto
    Department of Urology, Kagawa University Faculty of Medicine, Kita gun, Kagawa, Japan
    Prostate 71:438-44. 2011
    ....
  52. doi request reprint Influence of inflammation and aging on macrophage inhibitory cytokine-1 gene expression in rat ventral prostate
    Susumu Taniguchi
    Department of Urology, Kagawa University Faculty of Medicine, Kita gun, Kagawa, Japan
    Urology 73:410-4. 2009
    ..The aim of this study was to investigate the histologic changes and MIC-1 gene expression in the prostate of young nonbacterial prostatitis model (Y-NBP) and aging rats...
  53. ncbi request reprint Correlation of initial PSA level and biopsy features with PSA-doubling time in early stage prostate cancers in Japanese men
    Yoshiyuki Kakehi
    Department of Urology, Faculty of Medicine Kagawa Medical University, Kita gun, Japan
    Eur Urol 41:47-53. 2002
    ..To distinguish good candidates for watchful waiting from those who need immediate treatment in localized prostate cancer...
  54. ncbi request reprint TRAIL and chemotherapeutic drugs in cancer therapy
    Xiu Xian Wu
    Department of Urology, Kagawa University, Kagawa 761 0793, Japan
    Vitam Horm 67:365-83. 2004
    ..This review addresses the putative role of TRAIL in cancer treatment and discusses the molecular basis of the synergistic effect of TRAIL and chemotherapeutic drugs...
  55. ncbi request reprint Short-term effects of TNP-470 in combination with cisplatin in the rat model of bladder cancer
    Xianghua Zhang
    Department of Urology, Kagawa Medical University, 1750 1 Miki cho Kita gun, Kagawa 761 0793, Japan
    In Vivo 16:293-7. 2002
    ..To investigate the short-term effects of TNP-470 in combination with cisplatin in a rat model of bladder cancer...
  56. ncbi request reprint [Therapeutic strategy for prostate specific antigen (PSA) failure after radical prostatectomy]
    Hidefumi Kinoshita
    Department of Urology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawaramachi, Sakyo ku, Kyoto 606 8507, Japan
    Gan To Kagaku Ryoho 30:32-7. 2003
    ..The aim of salvage radiotherapy is a cure and this is quite different from other options, for example, endocrine therapy. Salvage radiotherapy is likely to become more important as a treatment for PSA failure after radical prostatectomy...
  57. doi request reprint A case of pheochromocytoma complicated with slowly progressive type 1 diabetes mellitus and chronic thyroiditis
    Koji Murao
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750 1, Miki cho, Kita gun 761 0793, Kagawa, Japan
    Endocrine 32:350-3. 2007
    ....
  58. ncbi request reprint 18-year recurrence-free survival after extensive surgery for kidney cancer with atrial tumor thrombi
    Mohammed Ahmed Abdel Muneem Nouh
    Department of Urology, Kagawa University, Faculty of Medicine, Kagawa, Japan
    Int J Urol 14:957-9. 2007
    ..To our knowledge, this is the first reported case of extensive surgery on advanced renal cell carcinoma with no evidence of recurrence for 18 years...
  59. doi request reprint Dietary administration of mushroom mycelium extracts in patients with early stage prostate cancers managed expectantly: a phase II study
    Yoshiteru Sumiyoshi
    Department of Urology, Shikoku Cancer Center, Ko 16, Minamiumemoto, Mastuyama, Ehime 791 0280, Japan
    Jpn J Clin Oncol 40:967-72. 2010
    ..To assess the efficacy and safety of dietary supplements in patients with early stage prostate cancers who are managed expectantly...
  60. doi request reprint Pre-existing arteriosclerotic intimal thickening in living-donor kidneys reflects allograft function
    Tadashi Sofue
    Division of Nephrology and Dialysis, Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Am J Nephrol 36:127-35. 2012
    ..Therefore, we investigated whether arteriosclerotic vasculopathy in living-donor kidneys at the time of transplantation predicts the recipient's kidney function (allograft function) later in life...
  61. doi request reprint Health-related quality of life evaluation in patients undergoing cavernous nerve reconstruction during radical prostatectomy
    Mikio Sugimoto
    Department of Urology, Kagawa University Faculty of Medicine, Kita gun, Kagawa, Japan
    Jpn J Clin Oncol 39:671-6. 2009
    ....
  62. doi request reprint Renal cell carcinoma in patients with end-stage renal disease: relationship between histological type and duration of dialysis
    Mohammed A A M Nouh
    Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan
    BJU Int 105:620-7. 2010
    ..To evaluate the clinical outcomes and histological types of renal cell carcinoma (RCC) arising in patients with end-stage renal disease (ESRD), and to analyse the relationship of histopathological features with the duration of dialysis...
  63. ncbi request reprint Watchful waiting as a treatment option for localized prostate cancer in the PSA era
    Yoshiyuki Kakehi
    Department of Urology, Faculty of Medicine, Kagawa Medical University, Kita gun, Kagawa, Japan
    Jpn J Clin Oncol 33:1-5. 2003
    ....
  64. doi request reprint Adult extrarenal Wilms' tumor mimicking mixed epithelial and stromal tumor in the retroperitoneum: a case report with immunohistochemical study and review of the literature
    Kyuichi Kadota
    Department of Diagnostic Pathology, University Hospital, Faculty of Medicine, Kagawa University, 1750 1, Ikenobe, Miki cho, Kagawa, 761 0793, Japan
    Pathol Oncol Res 15:665-9. 2009
    ..Furthermore, the present case showed predominant smooth muscle differentiation and a mature glandular structure, mimicking a mixed epithelial and stromal tumor...
  65. doi request reprint Improvement in renal dysfunction and symptoms after laparoscopic adrenalectomy in a patient with pheochromocytoma complicated by renal dysfunction
    Mako Fujiwara
    Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, 761 0793, Japan
    Endocrine 35:57-62. 2009
    ..Furthermore, his renal function improved (Cr 2.0-1.2 mg/dl). Our patient exhibited a rare condition of pheochromocytoma complicated by renal failure, which was successfully treated with laparoscopic surgery...
  66. doi request reprint Japanese Urological Association guidelines on prostate-specific antigen-based screening for prostate cancer and the ongoing cluster cohort study in Japan
    Kazuto Ito
    Department of Urology, Gunma University Graduate School of Medicine, Gunma, Japan
    Int J Urol 15:763-8. 2008
    ..8 times higher than in 2000. Therefore, there is an urgent need to determine the best available countermeasures to decrease the rate of prostate cancer death...
  67. ncbi request reprint Down-regulation of macrophage inhibitory cytokine-1/prostate derived factor in benign prostatic hyperplasia
    Yoshiyuki Kakehi
    Department of Urology, Faculty of Medicine, Kagawa University, Miki cho, Kita gun, Kagawa, Japan
    Prostate 59:351-6. 2004
    ..Macrophage inhibitory cytokine-1 (MIC-1) is a member of transforming growth factor-beta/bone morphogenetic protein (BMP) superfamily. Despite its potential role in prostatic regulation, little is known about its biological activity...
  68. ncbi request reprint Radical cystectomy for invasive bladder cancer: results of multi-institutional pooled analysis
    Atsushi Takahashi
    Department of Urology, Sapporo Medical University School of Medicine, Japan
    Jpn J Clin Oncol 34:14-9. 2004
    ..We report the outcome of radical cystectomy for patients with invasive bladder cancer, who did not have regional lymph node or distant metastases, at 21 hospitals...
  69. ncbi request reprint Follow-up of clinical stage I testicular cancer patients: cost and risk benefit considerations
    Yoshiyuki Kakehi
    Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Int J Urol 9:154-60; discussion 160-1. 2002
    ..Achieving a balance between survival and the patient's inconvenience and expense during follow-up, has therefore become an important issue...
  70. doi request reprint Delineation of apoptotic genes for synergistic apoptosis of lexatumumab and anthracyclines in human renal cell carcinoma cells by polymerase chain reaction array
    Xinghua Jin
    Qiqihar Medical University, Qiqihar, China
    Anticancer Drugs 23:445-54. 2012
    ..The present study demonstrates that anthracylines sensitize RCC cells to lexatumumab-mediated apoptosis by inducing TRAIL-R2 expression, and the utility of PCR array to elucidate the mechanism of synergistic apoptosis...
  71. ncbi request reprint Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by raloxifene, an antiestrogen with anti-androgen action, but not nimesulide, a selective cyclooxygenase-2 inhibitor
    Yu Zeng
    Onco Pathology, Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Carcinogenesis 26:1109-16. 2005
    ....
  72. doi request reprint Evidence-based clinical practice guidelines for renal cell carcinoma (Summary--JUA 2007 Edition)
    Tomoaki Fujioka
    Department of Urology, Iwate Medical University School of Medicine, Morioka, Iwate, Japan
    Int J Urol 16:339-53. 2009
    ..An abridged edition of these guidelines can be found on the web pages of the Japan Society of Clinical Oncology and the Medical Information Network Distribution Service...
  73. doi request reprint Molecular phylogeography of Culex quinquefasciatus mosquitoes in central Bangladesh
    Arif Ul Hasan
    Department of International Medical Zoology, Faculty of Medicine, Kagawa University, Kita gun, Kagawa Ken 761 0793, Japan
    Acta Trop 112:106-14. 2009
    ..quinquefasciatus had dispersed within this region. The study also reveals historical population expansion in this region, followed by a post-expansion Wolbachia sweep...
  74. doi request reprint Expression and secretion of N-acylethanolamine-hydrolysing acid amidase in human prostate cancer cells
    Jun Wang
    Department of Biochemistry, Kagawa University School of Medicine, Kagawa, Japan
    J Biochem 144:685-90. 2008
    ..These results showed that both the enzymes were functionally active. We also found that NAAA was partly secreted from LNCaP cells, which underlined possible usefulness of this enzyme as a biomarker of prostate cancer...
  75. ncbi request reprint Doxorubicin enhances TRAIL-induced apoptosis in prostate cancer
    Xiu Xian Wu
    Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Int J Oncol 20:949-54. 2002
    ....
  76. ncbi request reprint Cyclin D1 gene polymorphism is associated with an increased risk of urinary bladder cancer
    Lizhong Wang
    Department of Urology, Akita University School of Medicine, Akita 010 8543, Japan
    Carcinogenesis 23:257-64. 2002
    ..These data suggest that the CCND1 variant A allele may be associated with an increased risk of TCC of the bladder, especially in men without a history of smoking, and it may also have an effect on its disease status...
  77. ncbi request reprint Association of prostatic inflammation with down-regulation of macrophage inhibitory cytokine-1 gene in symptomatic benign prostatic hyperplasia
    Rikiya Taoka
    Department of Urology and Pathology, Faculty of Medicine, Kagawa University, Kita gun, Kagawa, Japan
    J Urol 171:2330-5. 2004
    ..We compared the histopathological features of inflammatory changes in prostate adenoma tissues from individuals with symptomatic and asymptomatic (histological only) BPH using MIC-1 mRNA levels...
  78. ncbi request reprint Angiogenesis in renal cell carcinoma: Evaluation of microvessel density, vascular endothelial growth factor and matrix metalloproteinases
    Xianghua Zhang
    Department of Urology, Kagawa Medical University, Kagawa, Japan
    Int J Urol 9:509-14. 2002
    ..The purpose of this study was to investigate the involvement of angiogenesis and angiogenic factors in the pathogenesis of renal cell carcinoma (RCC)...
  79. ncbi request reprint Transitional cell carcinoma of the ureteral stump eight years after nephrectomy for benign disease
    Masashi Inui
    Department of Urology, Kagawa Medical University, Kagawa, Japan
    Int J Urol 9:515-6. 2002
    ..A computed tomography showed a solid mass on the region of the right ureteral stump. He underwent a right ureterectomy and bladder cuff resection. A pathological examination showed transitional cell carcinoma...
  80. doi request reprint Evidence-based clinical practice Guidelines for Prostate Cancer (Summary - JUA 2006 Edition)
    Sadao Kamidono
    Int J Urol 15:1-18. 2008
  81. ncbi request reprint The Second Joint Meeting of American Urological Association (AUA)/Japanese Urological Association (JUA) International Program on the 102nd Annual Meeting of American Urological Association at Anaheim 2007
    Kenneth Ogan
    Emory University, USA
    Int J Urol 14:1116-23. 2007
  82. ncbi request reprint [The Japanese translation and cultural adaptation of Expanded Prostate Cancer Index Composite (EPIC)]
    Misa Takegami
    Department of Outcome Research, Institute for Health Outcomes and Process Evaluation Research
    Nihon Hinyokika Gakkai Zasshi 96:657-69. 2005
    ....
  83. ncbi request reprint [Translation and adaptation of the UCLA prostate cancer index for use in Japan]
    Yoshimi Suzukamo
    Department of Epidemiology and Health Care Research, Kyoto University
    Nihon Hinyokika Gakkai Zasshi 93:659-68. 2002
    ..To translate the UCLA Prostate Cancer Index (UCLA PCI), which is designed to measure Quality of Life (QOL) of patients with prostate cancer, and to adapt it as needed for use in Japan...
  84. ncbi request reprint [Treatment strategy for advanced prostate cancer with bone metastases]
    Mikio Sugimoto
    Dept of Urology, Kagawa University
    Gan To Kagaku Ryoho 33:1065-71. 2006
    ..In the future, we believe that the appearance of new anticancer drugs, endocrine therapies, bisphosphonates and strontium treatment could be used as a part of the treatment strategy for prostate cancer with bone metastases...
  85. ncbi request reprint [Treatment strategy for prostate cancer]
    Yoshiyuki Kakehi
    Department of Urology, Kagawa Medical University
    Nihon Rinsho 60:170-6. 2002
  86. ncbi request reprint [Cancer prevention]
    Hideyuki Akaza
    Dept of Urology, Institute of Clinical Medicine, University of Tsukuba
    Gan To Kagaku Ryoho 32:1499-506. 2005
    ..Overall, cancer prevention is still in evolution. New approaches are needed, and new infrastructure will be needed at a government level to implement this...
  87. ncbi request reprint [A case of regionally metastatic pure squamous cell carcinoma of the urinary bladder successfully treated with radical chemoradiotherapy]
    Masashi Inui
    Department of Urology, Kagawa Medical University
    Hinyokika Kiyo 48:33-5. 2002
    ..Pathological complete response was found both in bladder and regional lymph nodes when he underwent radical cystectomy and lymph node dissection. The patient has been alive without evidence of disease for two years postoperatively...
  88. ncbi request reprint Induction and function of CYR61 (CCN1) in prostatic stromal and epithelial cells: CYR61 is required for prostatic cell proliferation
    Shinji Sakamoto
    Pharmaceutical Frontier Research Laboratories, JT Inc, Yokohama City, Japan
    Prostate 61:305-17. 2004
    ..To determine whether or not CYR61 has relevance to the progression of benign prostatic hyperplasia (BPH), we investigated the induction of CYR61, and also examined its function in both prostatic stromal and epithelial cells...
  89. ncbi request reprint Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma
    Masayuki Tanaka
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    FEBS Lett 571:197-204. 2004
    ..The present study demonstrates active LPA metabolism in seminal plasma and indicates the possible role of LPA signaling in male sexual organs including prostate cancer...
  90. pmc Increased expression of CYR61, an extracellular matrix signaling protein, in human benign prostatic hyperplasia and its regulation by lysophosphatidic acid
    Shinji Sakamoto
    Pharmaceutical Frontier Research Laboratories, JT Inc, 13 2, Fukuura 1 chome, Kanazawa Ku, Yokohama 236 0004, Japan
    Endocrinology 145:2929-40. 2004
    ....
  91. pmc Symptomatic and asymptomatic benign prostatic hyperplasia: molecular differentiation by using microarrays
    Kulkarni Prakash
    Gene Logic Inc, 708 Quince Orchard Road, Gaithersburg, MD 20878, USA
    Proc Natl Acad Sci U S A 99:7598-603. 2002
    ..This genetic signature separates BPH from normal tissue but does not seem to change with age. These data could provide novel approaches for alleviating symptoms and hyperplasia in BPH...
  92. ncbi request reprint [Molecular targeted therapy for renal cell carcinoma]
    Yoshiyuki Kakehi
    Rinsho Ketsueki 49:622-5. 2008
  93. ncbi request reprint Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family
    Hideki Sakagami
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
    J Biol Chem 280:23084-93. 2005
    ..The present results suggest that NPP6 has a specific role through the hydrolysis of polyunsaturated LPC, glycerophosphorylcholine, or sphingosylphosphorylcholine in these organs...