Cheng Long Huang

Summary

Affiliation: Kagawa Medical University
Country: Japan

Publications

  1. ncbi Tailor-made chemotherapy for non-small cell lung cancer patients
    Cheng Long Huang
    Second Department of Surgery, Faculty of Medicine, Kagawa University, 1750 1, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Future Oncol 2:289-99. 2006
  2. pmc Neural-cadherin expression associated with angiogenesis in non-small-cell lung cancer patients
    T Nakashima
    Second Department of Surgery, Kagawa Medical University, 1750 1 Miki cho, Kita gun, Japan
    Br J Cancer 88:1727-33. 2003
  3. pmc The clinical significance of splice variants and subcellular localisation of survivin in non-small cell lung cancers
    J Nakano
    Second Department of Surgery, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Br J Cancer 98:1109-17. 2008
  4. pmc The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients
    D Masuya
    Second Department of Surgery, Kagawa Medical University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    Br J Cancer 90:1555-62. 2004
  5. pmc Evaluations of biomarkers associated with 5-FU sensitivity for non-small-cell lung cancer patients postoperatively treated with UFT
    J Nakano
    Faculty of Medicine, Second Department of Surgery, Kagawa University, 1750 1, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Br J Cancer 95:607-15. 2006
  6. ncbi MRP-1/CD9 gene transduction downregulates Wnt signal pathways
    Cheng Long Huang
    The Second Department of Surgery, Faculty of Medicine, Kagawa University, 1750 1, Miki cho, Kita gun, 761 0793, Japan
    Oncogene 23:7475-83. 2004
  7. ncbi MRP-1/CD9 gene transduction regulates the actin cytoskeleton through the downregulation of WAVE2
    C L Huang
    The Second Department of Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Oncogene 25:6480-8. 2006
  8. ncbi Wnt5a expression is associated with the tumor proliferation and the stromal vascular endothelial growth factor--an expression in non-small-cell lung cancer
    Cheng Long Huang
    Department of Second Surgery, Faculty of Medicine, Kagawa University, 1750 1, Miki cho, Kita gun, Kagawa 761 0793, Japan
    J Clin Oncol 23:8765-73. 2005
  9. doi Wnt1 overexpression promotes tumour progression in non-small cell lung cancer
    Cheng Long Huang
    Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Faculty of Medicine, Kagawa University, Kita gun, Kagawa, Japan
    Eur J Cancer 44:2680-8. 2008
  10. pmc Clinical application of biological markers for treatments of resectable non-small-cell lung cancers
    C Huang
    Second Department Surgery, Faculty of Medicine, Kagawa University, 1750 1, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Br J Cancer 92:1231-9. 2005

Collaborators

Detail Information

Publications62

  1. ncbi Tailor-made chemotherapy for non-small cell lung cancer patients
    Cheng Long Huang
    Second Department of Surgery, Faculty of Medicine, Kagawa University, 1750 1, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Future Oncol 2:289-99. 2006
    ..The remaining populations of non-small cell lung cancers require chemotherapy using other drugs based on an evaluation of other targeted molecules...
  2. pmc Neural-cadherin expression associated with angiogenesis in non-small-cell lung cancer patients
    T Nakashima
    Second Department of Surgery, Kagawa Medical University, 1750 1 Miki cho, Kita gun, Japan
    Br J Cancer 88:1727-33. 2003
    ..Thus, N-cadherin also might play a specific role in undifferentiated large cell carcinomas...
  3. pmc The clinical significance of splice variants and subcellular localisation of survivin in non-small cell lung cancers
    J Nakano
    Second Department of Surgery, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Br J Cancer 98:1109-17. 2008
    ..In contrast, the survivin-2B gene expression did not correlate with tumour proliferation or tumour apoptosis...
  4. pmc The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients
    D Masuya
    Second Department of Surgery, Kagawa Medical University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    Br J Cancer 90:1555-62. 2004
    ..642, P=0.0029). The present study demonstrates that tumour-stromal interaction between tumour cell-derived c-Met and stromal cell-derived HGF affects tumour growth and the prognosis of NSCLC patients...
  5. pmc Evaluations of biomarkers associated with 5-FU sensitivity for non-small-cell lung cancer patients postoperatively treated with UFT
    J Nakano
    Faculty of Medicine, Second Department of Surgery, Kagawa University, 1750 1, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Br J Cancer 95:607-15. 2006
    ..663; P=0.0003), OPRT status (hazard ratio 2.543; P=0.0005), and DPD status (hazard ratio 2.840; P<0.0001) to all be significant prognostic factors for the survival of resected NSCLC patients postoperatively treated with UFT...
  6. ncbi MRP-1/CD9 gene transduction downregulates Wnt signal pathways
    Cheng Long Huang
    The Second Department of Surgery, Faculty of Medicine, Kagawa University, 1750 1, Miki cho, Kita gun, 761 0793, Japan
    Oncogene 23:7475-83. 2004
    ..Therefore, MRP-1/CD9 could suppress cell transformation including epithelial to mesenchymal transition through downregulation of Wnt1, and might suppress tumor metastasis through downregulation of Wnt5a...
  7. ncbi MRP-1/CD9 gene transduction regulates the actin cytoskeleton through the downregulation of WAVE2
    C L Huang
    The Second Department of Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Oncogene 25:6480-8. 2006
    ..Transfection of WAVE2-specific siRNA also did not affect expressions of these Wnts. These results indicate that MRP-1/CD9 regulates the actin cytoskeleton by downregulating of the WAVE2, through the Wnt-independent signal pathway...
  8. ncbi Wnt5a expression is associated with the tumor proliferation and the stromal vascular endothelial growth factor--an expression in non-small-cell lung cancer
    Cheng Long Huang
    Department of Second Surgery, Faculty of Medicine, Kagawa University, 1750 1, Miki cho, Kita gun, Kagawa 761 0793, Japan
    J Clin Oncol 23:8765-73. 2005
    ..The Wnt gene family encodes the multifunctional signaling glycoproteins. We performed the present study to investigate the clinical significance of Wnt5a expression in non-small-cell lung cancer (NSCLC)...
  9. doi Wnt1 overexpression promotes tumour progression in non-small cell lung cancer
    Cheng Long Huang
    Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Faculty of Medicine, Kagawa University, Kita gun, Kagawa, Japan
    Eur J Cancer 44:2680-8. 2008
    ..The Wnt gene family is involved in embryogenesis and tumourigenesis. We investigated the clinical significance of Wnt1 expression in non-small cell lung cancer (NSCLC)...
  10. pmc Clinical application of biological markers for treatments of resectable non-small-cell lung cancers
    C Huang
    Second Department Surgery, Faculty of Medicine, Kagawa University, 1750 1, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Br J Cancer 92:1231-9. 2005
    ..Thymidylate synthase expression is also a useful marker to evaluate responsiveness of UFT-based chemotherapy for these tumours...
  11. ncbi Clinical significance of the p53 pathway and associated gene therapy in non-small cell lung cancers
    Cheng Long Huang
    Second Department of Surgery, Faculty of Medicine, Kagawa University, 1750 1, Mikicho, Kita gun, Kagawa 761 0793, Japan
    Future Oncol 3:83-93. 2007
    ..Thus, the establishment of a comprehensive and simple evaluation protocol for the p53 pathway is required for clinical use...
  12. ncbi E2F1 overexpression correlates with thymidylate synthase and survivin gene expressions and tumor proliferation in non small-cell lung cancer
    Cheng Long Huang
    Department of Second Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Clin Cancer Res 13:6938-46. 2007
    ..We investigated the clinical significance of E2F1 gene expression in relation to its target genes, thymidylate synthase (TS) and Survivin, in case of non-small-cell lung cancer (NSCLC)...
  13. ncbi Reduced ING1b gene expression plays an important role in carcinogenesis of non-small cell lung cancer patients
    Kotaro Kameyama
    The Second Department of Surgery, Kagawa Medical University, Kagawa 761 0793, Japan
    Clin Cancer Res 9:4926-34. 2003
    ..We performed a clinical study on ING1b gene expression and p53 gene status in relation to p53 target genes...
  14. ncbi The expression of LDL receptor in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model
    Masaki Ueno
    Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, Kita gun, Kagawa, Japan
    Histochem Cell Biol 133:669-76. 2010
    ....
  15. ncbi Topoisomerase IIalpha gene expression is regulated by the p53 tumor suppressor gene in nonsmall cell lung carcinoma patients
    DaGe Liu
    Second Department of Surgery, Kagawa Medical University, Kagawa, Japan
    Cancer 94:2239-47. 2002
    ..Previous experimental studies using cell lines reported that Topo IIalpha expression was negatively regulated by wild-type p53 through the gene's promoter region...
  16. ncbi Wnt1 overexpression associated with tumor proliferation and a poor prognosis in non-small cell lung cancer patients
    Takashi Nakashima
    Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Oncol Rep 19:203-9. 2008
    ..983; P=0.0061). Our results revealed that the Wnt1 overexpression affects the tumor proliferation in NSCLCs, partly via the upregulation of c-Myc...
  17. ncbi Cartilage regeneration using slow release of bone morphogenetic protein-2 from a gelatin sponge to treat experimental canine tracheomalacia: a preliminary report
    Taku Okamoto
    Second Department of Surgery, Kagawa Medical University, 1750 1, Ikenobe, Miki cho, Kita gun, Kagawa, Japan 761 0793
    ASAIO J 49:63-9. 2003
    ..The regeneration of cartilage or bone induced by the slow release of BMP-2 from a gelatin sponge might be useful for treatment of tracheomalacia...
  18. ncbi Blood-brain barrier is impaired in the hippocampus of young adult spontaneously hypertensive rats
    Masaki Ueno
    Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe Miki cho, 761 0793 Kita gun, Kagawa, Japan
    Acta Neuropathol 107:532-8. 2004
    ..These findings suggest that the chronic hypertensive state induces BBB dysfunction in the hippocampus at an early stage...
  19. ncbi Clinical analysis of interstitial pneumonia after surgery for lung cancer
    Taku Okamoto
    Second Department of Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Jpn J Thorac Cardiovasc Surg 52:323-9. 2004
    ..The postoperative development or exacerbation of interstitial pneumonia (IP) in lung cancer patients often affects prognoses. We analyzed the patients who suffered from IP after surgery, to determine treatment and prevention of IP...
  20. ncbi Expression of vascular endothelial growth factor-A and vascular endothelial growth factor-C as prognostic factors for non-small cell lung cancer
    Takashi Nakashima
    Second Department of Surgery, Kagawa Medical University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    Med Sci Monit 10:BR157-65. 2004
    ..The aim of our study was to clarify the clinical value of vascular endothelial growth factor-A (VEGF-A) and VEGF-C in non-small cell lung cancer (NSCLC)...
  21. ncbi Survivin gene expression is negatively regulated by the p53 tumor suppressor gene in non-small cell lung cancer
    Jun Nakano
    Second Department of Surgery, Faculty of Medicine, Kagawa University, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 27:1215-21. 2005
    ..0047). This study indicated survivin gene expression to be negatively regulated by p53 in NSCLC, and that survivin expression could inhibit apoptosis and accelerate tumor cell proliferation to produce more aggressive carcinomas...
  22. ncbi Age-related changes in P-glycoprotein expression in senescence-accelerated mouse
    Bin Wu
    Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Curr Aging Sci 2:187-92. 2009
    ....
  23. ncbi The clinical significance of the tumor cell D2-40 immunoreactivity in non-small cell lung cancer
    Kyuichi Kadota
    Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Faculty of Medicine, Kagawa University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    Lung Cancer 70:88-93. 2010
    ..A monoclonal antibody D2-40 has been widely used for tumor lymphangiogenesis and lymphatic vessel invasion (LVI) in human cancers. However, the clinical significance of the tumor cell D2-40 immunoreactivity has not been clearly understood...
  24. doi Combined therapy with a thymidylate synthase-inhibiting vector and S-1 has effective antitumor activity against 5-FU-resistant tumors
    Kyuichi Kadota
    Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Int J Oncol 38:355-63. 2011
    ..Consequently, the combined treatment of the TS-inhibiting adenoviral vector and S-1 has effective antitumor activity against 5-FU-resistant tumors...
  25. ncbi Pulmonary embolism after lung resection: diagnosis and treatment
    Kotaro Kameyama
    Second Department of Surgery, Kagawa Medical University, Kagawa, Japan
    Ann Thorac Surg 76:599-601. 2003
    ..Thus echocardiography may become a primary procedure to confirm the diagnosis of severe PEALR, and thrombolysis with second-generation r-tPA may be the preferred choice for treatment...
  26. ncbi Induction chemotherapy before operation for multiple endobronchial squamous cell carcinoma of the lung
    Kotaro Kameyama
    Second Department of Surgery, Kagawa Medical University, Kita gun, Japan
    Ann Thorac Surg 74:1008-10. 2002
    ..In this study, we evaluated the efficacy of preoperative induction chemotherapy for patients with otherwise unresectable multiple endobronchial squamous cell carcinoma and poor pulmonary function...
  27. ncbi En bloc partial vertebrectomy for lung cancer invading the spine after induction chemoradiotherapy
    Hiroyasu Yokomise
    2nd Department of Surgery, Faculty of Medicine, Kagawa University, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Eur J Cardiothorac Surg 31:788-90. 2007
    ..We reviewed our experiences of NSCLC with vertebral body invasion, in which we have performed induction chemoradiotherapy followed by lung resection with en bloc partial vertebrectomy...
  28. doi Expression of IGF1R is associated with tumor differentiation and survival in patients with lung adenocarcinoma
    Ryutaro Kikuchi
    Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Ann Surg Oncol 19:S412-20. 2012
    ..The insulin-like growth factor 1 receptor (IGF1R) is widely expressed in normal tissues and many malignancies in humans. We investigated the clinical significance of the expression of the IGF1R gene in human lung adenocarcinoma...
  29. ncbi Effects of aging and HIF-1alpha deficiency on permeability of hippocampal vessels
    Masaki Ueno
    Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Microsc Res Tech 69:29-35. 2006
    ..There were no leaky vessels in 10-week-old mutant mice or 10-week-old and 24-month-old control mice. These findings suggest the necessity of two factors, aging and hydrocephalus, for BBB dysfunction in HIF-1alpha deficient mice...
  30. ncbi Intratumoral Wnt1 expression affects survivin gene expression in non-small cell lung cancer
    Nariyasu Nakashima
    Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Int J Oncol 37:687-94. 2010
    ..0001), the Ki-67 proliferation index (P<0.0001), and patient survival (P=0.0355). Intratumoral Wnt1 overexpression could produce more aggressive NSCLCs by induction of survivin...
  31. ncbi Problems related to TNM staging: patients with stage III non-small cell lung cancer
    Kotaro Kameyama
    Second Department of Surgery, Kagawa Medical University, Kagawa, Japan
    J Thorac Cardiovasc Surg 124:503-10. 2002
    ..For clarifying this problem, the present study was constructed in light of T3 and T4 classifications...
  32. ncbi Blood-brain barrier disruption in the hypothalamus of young adult spontaneously hypertensive rats
    Masaki Ueno
    Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, 761 0793, Kagawa, Japan
    Histochem Cell Biol 122:131-7. 2004
    ..These findings suggest that BBB disruption occurs in the hypothalamus of 3-month-old SHR and SHRSP, and that endothelial glycocalyx is markedly damaged there without a close relationship to the early changes in the BBB...
  33. ncbi The clinical significance of lymphangiogenesis and angiogenesis in non-small cell lung cancer patients
    Kyuichi Kadota
    Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Faculty of Medicine, Kagawa University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    Eur J Cancer 44:1057-67. 2008
    ..Angiogenesis and lymphangiogenesis have been reported to affect malignant phenotype...
  34. ncbi Development of a canine model of pulmonary emphysema and imaging of the emphysematous lung with infrared thoracoscopy
    Masashi Gotoh
    Second Department of Surgery, Kagawa Medical University, Kita gun, Japan
    J Thorac Cardiovasc Surg 126:1916-21. 2003
    ..The surgeon must use the results of preoperative computed tomography findings and scintigraphic studies to make a subjective decision during lung volume reduction surgery with regard to the best incision line...
  35. ncbi Overexpression of matrix metalloproteinase-7 (MMP-7) correlates with tumor proliferation, and a poor prognosis in non-small cell lung cancer
    DaGe Liu
    Second Department of Surgery, Faculty of Medicine, Kagawa University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    Lung Cancer 58:384-91. 2007
    ..We performed a retrospective study on the MMP-7 expression in non-small cell lung cancer (NSCLC) according to the clinical characteristics, biological markers and the Wnt1 expression...
  36. doi Adenoviral vector expressing short hairpin RNA targeting Wnt2B has an effective antitumour activity against Wnt2B2-overexpressing tumours
    DaGe Liu
    Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Faculty of Medicine, Kagawa University, Miki cho, Kita gun, Kagawa, Japan
    Eur J Cancer 48:1208-18. 2012
    ..Wnt2B overexpression is thought to affect tumour progression through the activation of the canonical Wnt pathway...
  37. ncbi Induction chemoradiotherapy (carboplatin-taxane and concurrent 50-Gy radiation) for bulky cN2, N3 non-small cell lung cancer
    Hiroyasu Yokomise
    Second Department of Surgery, Faculty of Medicine, Kagawa University, Miki cho, Japan
    J Thorac Cardiovasc Surg 133:1179-85. 2007
    ..To improve the prognosis of cN2, N3 non-small cell lung cancer, we performed induction chemoradiotherapy (carboplatin-taxane chemotherapy and concurrent 50-Gy radiation) followed by surgery...
  38. ncbi Large cell carcinoma with neuroendocrine morphology of the lung
    Daiki Masuya
    Second Department of Surgery, Faculty of Medicine, Kagawa University, Japan
    Jpn J Thorac Cardiovasc Surg 54:31-4. 2006
    ..Immunohistochemical examination finally diagnosed the tumor as LCCNM. The patient is doing well without recurrence at ten months after surgery...
  39. ncbi A useful protocol for analyses of mutations of the epidermal growth factor receptor gene
    DaGe Liu
    Second Department of Surgery, Kagawa University, Kita gun, Kagawa 761 0793, Japan
    Oncol Rep 15:1503-5. 2006
    ..The current study suggests that DNA extraction with the DEXPAT kit followed by nested PCR is a simple and reliable technique for analyzing the EGFR gene status with paraffin-embedded samples...
  40. doi RAGE, LDL receptor, and LRP1 expression in the brains of SAMP8
    Bin Wu
    Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Neurosci Lett 461:100-5. 2009
    ..These findings suggest that the lower expression of RAGE and the higher expression of LDLR may contribute to clearance of toxic substances and, in addition, be related to elevated oxidative stress in SAMP8 brains...
  41. ncbi Progressive growth of primary synovial sarcoma of the lung
    Jun Nakano
    Department of General Thoracic, Breast, and Endoclinological Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Ann Thorac Cardiovasc Surg 16:194-7. 2010
    ..A SYT-SSX2 fusion gene transcript was detected as a result of RT-PCR analysis. Because of these results, the tumor was diagnosed as a monophasic synovial sarcoma...
  42. ncbi Successful treatment for lung cancer associated with pulmonary sequestration
    Taku Okamoto
    Second Department of Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Ann Thorac Surg 80:2344-6. 2005
    ..Preservation of the sequestered lung during surgery for lung cancer should be considered in patients who have poor respiratory function and no signs of respiratory infection...
  43. doi Wnt3 gene expression promotes tumor progression in non-small cell lung cancer
    Nariyasu Nakashima
    Department of General Thoracic Surgery, Faculty of Medicine, Kagawa University, 1750 1, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Lung Cancer 76:228-34. 2012
    ..During the progression of NSCLC, Wnt3 overexpression could be associated with the development of more aggressive tumors...
  44. doi Medulloblastoma with myogenic differentiation showing double immunopositivity for synaptophysin and myoglobin
    Mizue Kido
    Department of Pathology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Pathol Int 59:255-60. 2009
    ..Their Ki-67 labeling index was 54%. In addition, some tumor cells had double immunopositivity for synaptophysin or neurofilament and myoglobin, suggesting that the neuroectodermal cells may undergo differentiation into rhabdomyoblasts...
  45. doi Higher expression of EphA2 and ephrin-A1 is related to favorable clinicopathological features in pathological stage I non-small cell lung carcinoma
    Masashi Ishikawa
    Faculty of Medicine, Department of Thoracic Surgery, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto, 606 8507, Japan
    Lung Cancer 76:431-8. 2012
    ..We retrospectively evaluated the expression levels of EphA2 and ephrin-A1 in surgically treated pathological (p-) stage I NSCLC tumor samples, and their relation to clinicopathologic features or postoperative prognoses...
  46. doi The expression of matrix metalloproteinase-13 is increased in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model
    Masaki Ueno
    Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Hypertens Res 32:332-8. 2009
    ..These findings indicate that the expression of MMP-13 is increased in BBB-damaged hippocampal vessels in hypertensive SHRSP compared with vessels without BBB impairment in normotensive WKY rats and may be involved in vascular remodeling...
  47. ncbi [Prognosis of surgically treated large cell neuroendocrine carcinoma]
    Natsumi Matsuura
    Department of General Thoracic, Breast and Endocrinological Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Kyobu Geka 64:187-90. 2011
    ..The overall 5-year survival rate was 30.3%. Pulmonary LCNEC represents an aggressive tumor and multimodal treatment is required...
  48. ncbi Two pathways of apoptosis are simultaneously induced in the embryonal brains of neural cell-specific HIF-1alpha-deficient mice
    Masaki Ueno
    Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    Histochem Cell Biol 125:535-44. 2006
    ..These results suggest that two pathways of apoptosis are induced in neuronal and vascular cells of the cortex in the neural cell-specific HIF-1alpha-deficient mouse...
  49. ncbi Accumulation of triosephosphate isomerase, with sequence homology to Beta amyloid peptides, in vessel walls of the newborn piglet hippocampus
    Takashi Kusaka
    Maternal and Perinatal Center, Faculty of Medicine, Kagawa University, Miki cho 1750 1, Kita gun, Kagawa, Japan
    Microsc Res Tech 70:648-55. 2007
    ..These findings indicate that TPI with sequence homology to Abeta peptides accumulates in perivascular cells of the microglia/macrophage lineage located around arterial vessels of the newborn piglet hippocampus...
  50. ncbi Successful treatment of massive bleeding into the open thoracotomy space by pulmonary artery occlusion: report of a case
    Taku Okamoto
    Second Department of Surgery, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Surg Today 35:250-1. 2005
    ..After identification of the bleeding point, surgical hemostasis was successfully achieved following PA occlusion with a Swan-Ganz thermodilution catheter...
  51. doi Snail expression is associated with a poor prognosis in malignant pleural mesotheliomas
    Masashi Kobayashi
    Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Ann Thorac Surg 95:1181-8. 2013
    ..We aimed to clarify the mechanisms of epithelial-to-mesenchymal transition (EMT) in MPMs by analyzing the expressions of EMT-associated transcription factors and E-cadherin in relation to tumor proliferation rates and patient survival...
  52. ncbi Slow release of bone morphogenetic protein 2 from a gelatin sponge to promote regeneration of tracheal cartilage in a canine model
    Taku Okamoto
    Second Department of Surgery, Kagawa Medical University, Kita gun, Japan
    J Thorac Cardiovasc Surg 127:329-34. 2004
    ..We investigated whether bone morphogenetic protein 2, released slowly from a gelatin sponge, could induce cartilage regeneration in a canine model of tracheomalacia and evaluated the long-term results...
  53. ncbi Video-assisted thoracoscopic pericardial fenestration for tuberculous pericardial effusion
    Kotaro Kameyama
    Second Department of Surgery, Kagawa Medical University, Kita gun, Kagawa, Japan
    Jpn J Thorac Cardiovasc Surg 52:68-70. 2004
    ..We conclude that VATSPF can be a useful procedure not only for diagnosis but for release of tuberculous pericarditis with cardiac tamponade and for prophylaxis of constrictive pericarditis...
  54. ncbi A combined small cell carcinoma of the lung containing three components: small cell, spindle cell and squamous cell carcinoma
    Masashi Gotoh
    Second Department of Surgery, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki, Kagawa 761 0793, Japan
    Eur J Cardiothorac Surg 26:1047-9. 2004
    ..We report this case in view of the rarity of this combination of morphologic patterns in a primary bronchogenic carcinoma...
  55. ncbi Aberrant messenger RNA splicing of the cytokeratin 8 in lung cancer
    Yasunori Tojo
    First Department of Internal Medicine, Kagawa Medical University, 1750 1, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Lung Cancer 42:153-61. 2003
    ..AS-CK8 was preferentially expressed in NSCLC, rather than SCLC. These findings lead to speculation that cancer cells expressing AS-CK8 may have a resistance to apoptosis and may perturb keratin network formation...
  56. ncbi Lobar bronchial atresia demonstrating a cystic lesion without overinflation
    Masaya Okuda
    Second Department of Surgery, Faculty of Medicine, Kagawa University, 1750 1, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Eur J Cardiothorac Surg 30:391-3. 2006
    ..We herein report an adult case of lobar bronchial atresia who showed no hyperinflation of the peripheral pulmonary parenchyma...
  57. ncbi Myoepithelial carcinoma of the lung
    Daiki Masuya
    Department of Second Surgery, Faculty of Medicine, Kagawa University, 1750 1 Kita gun, Kagawa 761 0793, Japan
    Eur J Cardiothorac Surg 28:775-7. 2005
    ..Here we report a resected case of myoepithelial carcinoma of the lung, including details of clinical examination, with a review of previously documented cases...
  58. ncbi Clinical significance of BRAF gene mutations in patients with non-small cell lung cancer
    Masashi Kobayashi
    Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Anticancer Res 31:4619-23. 2011
    ..V-raf murine sarcoma viral oncogene homolog B1 (BRAF) mutations are attractive molecular targets for cancer treatment. Detection of BRAF gene mutation and analyses in non-small cell lung cancer (NSCLC) are of great scientific interest...
  59. doi Abcb1a and Abcb1b expression in senescence-accelerated mouse (SAM)
    Bin Wu
    Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Neurosci Lett 456:34-8. 2009
    ..The combination of SAMR1 and SAMP8 may be a good tool to investigate which transporter, Abcb1a or Abcb1b, can be used in drug delivery into the brain...
  60. doi Clear cell carcinoma originating from ectopic thymus
    Masaya Okuda
    Department of General Thoracic, Breast, and Endocrinological Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Gen Thorac Cardiovasc Surg 57:269-71. 2009
    ..We report a case of clear cell carcinoma originating from ectopic thymus in which there was a good response to steroid-supplemented chemoradiotherapy...
  61. ncbi A surgical case of primary lung cancer with peripheral intrapulmonary lymph node metastasis
    Daiki Masuya
    Department of Thoracic Surgery, Shinko Hospital, Kobe, Hyogo, Japan
    Ann Thorac Cardiovasc Surg 13:53-5. 2007
    ..This case suggests that a nodule is present in the same lobe with lung cancer, and it must be borne in mind that IPLN metastasis may be misdiagnosed as intrapulmonary metastasis...
  62. ncbi Bronchioloalveolar carcinoma masked by gravity-dependent gradient on computed tomography
    Shuji Bandoh
    First Department of Internal Medicine, Kagawa Medical University
    Intern Med 41:487-90. 2002
    ..CT with the patient in the prone position helps to exclude the gravitational effect and narrow the differential diagnosis of ground-glass opacity, including localized forms of BAC...