Takashi Himoto

Summary

Affiliation: Kagawa University
Country: Japan

Publications

  1. pmc Recent advances in radiofrequency ablation for the management of hepatocellular carcinoma
    Takashi Himoto
    Department of Integrated Medicine, Kagawa, Japan
    Hepat Mon 12:e5945. 2012
  2. pmc Investigation of the factors associated with circulating soluble CD36 levels in patients with HCV-related chronic liver disease
    Takashi Himoto
    Department of Integrated Medicine, Kagawa University School of Medicine, 1750 1, Ikenobe, Miki cho, Kagawa 7610 79, Japan
    Diabetol Metab Syndr 5:51. 2013
  3. doi request reprint The ratio of insulin-like growth factor-I/insulin-like growth factor-binding protein-3 in sera of patients with hepatitis C virus-related chronic liver disease as a predictive marker of insulin resistance
    Takashi Himoto
    Department of Integrated Medicine, Kagawa University School of Medicine, Kagawa, Japan
    Nutr Res 33:27-33. 2013
  4. pmc Extrahepatic manifestations and autoantibodies in patients with hepatitis C virus infection
    Takashi Himoto
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa, Japan
    Clin Dev Immunol 2012:871401. 2012
  5. doi request reprint Clinical relevance of antibodies to cardiolipin in patients with chronic hepatitis C
    Takashi Himoto
    Department of Integrated Medicine, Kagawa University School of Medicine, Kagawa, Japan
    J Clin Lab Anal 26:342-8. 2012
  6. pmc Clinical significance of autoantibodies to p53 protein in patients with autoimmune liver diseases
    Takashi Himoto
    Department of Integrated Medicine, Kagawa University School of Medicine, Kagawa, Japan
    Can J Gastroenterol 26:125-9. 2012
  7. doi request reprint Selenium deficiency is associated with insulin resistance in patients with hepatitis C virus-related chronic liver disease
    Takashi Himoto
    Department of Integrated Medicine, Kagawa University School of Medicine, Kagawa, Japan
    Nutr Res 31:829-35. 2011
  8. doi request reprint Contribution of zinc deficiency to insulin resistance in patients with primary biliary cirrhosis
    Takashi Himoto
    Department of Integrated Medicine, Kagawa University School of Medicine, 1750 1, Ikenobe, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    Biol Trace Elem Res 144:133-42. 2011
  9. doi request reprint Clinical characteristics of patients with hepatitis C virus-related chronic liver disease seropositive for anticentromere antibody
    Takashi Himoto
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa, Japan
    Dig Dis Sci 54:360-8. 2009
  10. ncbi request reprint Cytomegalovirus-associated acute gastric mucosal lesion in an immunocompetent host
    Takashi Himoto
    Department of Integrated Medicine, Kagawa University School of Medicine, Kagawa
    Intern Med 48:1521-4. 2009

Collaborators

Detail Information

Publications55

  1. pmc Recent advances in radiofrequency ablation for the management of hepatocellular carcinoma
    Takashi Himoto
    Department of Integrated Medicine, Kagawa, Japan
    Hepat Mon 12:e5945. 2012
    ..CONTEXTS: Hepatocellular carcinoma (HCC) is one of the most common malignant diseases in the world. Because less than 20% of patients with HCC are resectable, various types of non-surgical treatment have been developed...
  2. pmc Investigation of the factors associated with circulating soluble CD36 levels in patients with HCV-related chronic liver disease
    Takashi Himoto
    Department of Integrated Medicine, Kagawa University School of Medicine, 1750 1, Ikenobe, Miki cho, Kagawa 7610 79, Japan
    Diabetol Metab Syndr 5:51. 2013
    ..The primary purpose of this study was to investigate the role of CD36 in the pathogenesis of insulin resistance and hepatic steatosis caused by chronic HCV infection...
  3. doi request reprint The ratio of insulin-like growth factor-I/insulin-like growth factor-binding protein-3 in sera of patients with hepatitis C virus-related chronic liver disease as a predictive marker of insulin resistance
    Takashi Himoto
    Department of Integrated Medicine, Kagawa University School of Medicine, Kagawa, Japan
    Nutr Res 33:27-33. 2013
    ..411, P = .0094). These findings suggest that the decline of the circulating free IGF-I level, which derives from zinc deficiency, may contribute to hepatic steatosis and insulin resistance in patients with HCV-related CLD...
  4. pmc Extrahepatic manifestations and autoantibodies in patients with hepatitis C virus infection
    Takashi Himoto
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa, Japan
    Clin Dev Immunol 2012:871401. 2012
    ....
  5. doi request reprint Clinical relevance of antibodies to cardiolipin in patients with chronic hepatitis C
    Takashi Himoto
    Department of Integrated Medicine, Kagawa University School of Medicine, Kagawa, Japan
    J Clin Lab Anal 26:342-8. 2012
    ....
  6. pmc Clinical significance of autoantibodies to p53 protein in patients with autoimmune liver diseases
    Takashi Himoto
    Department of Integrated Medicine, Kagawa University School of Medicine, Kagawa, Japan
    Can J Gastroenterol 26:125-9. 2012
    ..Autoantibodies to p53 (anti-p53) are rarely present in the sera of patients with autoimmune diseases or the sera of patients with malignancies...
  7. doi request reprint Selenium deficiency is associated with insulin resistance in patients with hepatitis C virus-related chronic liver disease
    Takashi Himoto
    Department of Integrated Medicine, Kagawa University School of Medicine, Kagawa, Japan
    Nutr Res 31:829-35. 2011
    ....
  8. doi request reprint Contribution of zinc deficiency to insulin resistance in patients with primary biliary cirrhosis
    Takashi Himoto
    Department of Integrated Medicine, Kagawa University School of Medicine, 1750 1, Ikenobe, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    Biol Trace Elem Res 144:133-42. 2011
    ....
  9. doi request reprint Clinical characteristics of patients with hepatitis C virus-related chronic liver disease seropositive for anticentromere antibody
    Takashi Himoto
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa, Japan
    Dig Dis Sci 54:360-8. 2009
    ..18%, P = 0.0108). These findings suggest that ACA is induced by chronic HCV infection in association with HLA DR-8, and that CH-C patients with ACA exhibit more severe hepatic fibrosis and inflammation than CH-C patients without ANA...
  10. ncbi request reprint Cytomegalovirus-associated acute gastric mucosal lesion in an immunocompetent host
    Takashi Himoto
    Department of Integrated Medicine, Kagawa University School of Medicine, Kagawa
    Intern Med 48:1521-4. 2009
    ..This case illustrates that CMV infection can be one of the causative agents that trigger AGML even in immunocompetent hosts, and that gastric biopsies are extremely useful for ascertaining the etiology of AGML...
  11. doi request reprint Association between oxidative stress assessed by urinary 8-hydroxydeoxyguanosine and the cardiac function in hypertensive patients without overt heart disease
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kagawa, Japan
    Clin Exp Hypertens 35:308-12. 2013
    ..Therefore, an elevated urinary 8-OHdG level may be useful in detecting subclinical LV diastolic dysfunction in hypertensive patients without overt heart disease. ..
  12. ncbi request reprint Efficacy of zinc administration in patients with hepatitis C virus-related chronic liver disease
    Takashi Himoto
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa, Japan
    Scand J Gastroenterol 42:1078-87. 2007
    ..We therefore examined the effects of zinc administration on inflammatory activity and fibrosis in the liver of patients with HCV-related CLD...
  13. ncbi request reprint Comparison between combination therapy of percutaneous ethanol injection and radiofrequency ablation and radiofrequency ablation alone for patients with hepatocellular carcinoma
    Kazutaka Kurokohchi
    Third Department of Internal Medicine, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    World J Gastroenterol 11:1426-32. 2005
    ....
  14. ncbi request reprint Comparative study of the effects of percutaneous ethanol injection and radiofrequency ablation in cases treated with a straight or expandable electrode
    Kazutaka Kurokohchi
    Department of Gastroenterology, Kagawa University School of Medicine, Kagawa 761 0793, Japan
    Oncol Rep 18:1275-9. 2007
    ..Thus, prior injection of ethanol before RFA may make RFA treatment less invasive in the time-lag PEI-RFA using the expandable electrode as previously shown HCC cases treated with straight electrode...
  15. ncbi request reprint Efficacy of combination therapies of percutaneous or laparoscopic ethanol-lipiodol injection and radiofrequency ablation
    Kazutaka Kurokohchi
    Third Department of Internal Medicine, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 25:1737-43. 2004
    ..Therefore, it is critical to evaluate whether enough safety margin could be obtained with RFA therapy, and PELI-RFA and LELI-RFA are helpful in visualizing the safety margin area...
  16. doi request reprint Reduced bone mineral density in hypertensive patients is associated with left ventricular diastolic dysfunction, not left ventricular hypertrophy
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kagawa, Japan
    Clin Exp Hypertens 34:176-81. 2012
    ..Hypertensive patients with reduced bone mineral density may have a high risk of chronic heart failure due to LV diastolic dysfunction as well as bone fractures due to osteoporosis...
  17. pmc A combination therapy of ethanol injection and radiofrequency ablation under general anesthesia for the treatment of hepatocellular carcinoma
    Kazutaka Kurokohchi
    Department of Gastroenterology, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    World J Gastroenterol 14:2037-43. 2008
    ....
  18. ncbi request reprint Latent cardiac dysfunction as assessed by echocardiography in bed-bound patients following cerebrovascular accidents: comparison with nutritional status
    Hisashi Masugata
    Department of Integrated Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Int Heart J 48:505-12. 2007
    ..The Tei index may be a useful index of cardiac dysfunction in bed-bound patients because it is independent of the cardiac loading condition...
  19. doi request reprint Visit-to-visit variability in blood pressure over a 1-year period is a marker of left ventricular diastolic dysfunction in treated hypertensive patients
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kagawa, Japan
    Hypertens Res 34:846-50. 2011
    ..High visit-to-visit variability of SBP was associated with LV diastolic dysfunction and may constitute a high risk for diastolic heart failure in hypertensive patients...
  20. ncbi request reprint Association between bone mineral density and arterial stiffness in hypertensive patients
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kagawa, Japan
    Tohoku J Exp Med 223:85-90. 2011
    ..Therefore, hypertensive patients with increased arterial stiffness may have a high risk of bone fracture due to osteoporosis...
  21. ncbi request reprint Elevated brachial-ankle pulse wave velocity is associated with left ventricular hypertrophy in hypertensive patients after stroke
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kagawa, Japan
    Tohoku J Exp Med 220:177-82. 2010
    ..Elevated baPWV is independently associated with the severity of LV hypertrophy adjusted with systolic blood pressure and age in hypertensive patients after stroke...
  22. doi request reprint Relationship between arterial stiffness and variability in systolic blood pressure during a single clinic visit in patients with hypertension
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kagawa, Japan
    J Int Med Res 41:325-33. 2013
    ..To examine factors affecting systolic blood pressure (SBP) variability during a single clinic visit, in treated hypertensive patients...
  23. ncbi request reprint Successful laparoscopic radiofrequency ablation of hepatocellular carcinoma adhered to the mesentery after transcatheter arterial embolization
    Kazutaka Kurokohchi
    Third Department of Internal Medicine, Kagawa University School of Medicine, Kagawa 761 0793, Japan
    Oncol Rep 13:65-8. 2005
    ..The tumor was successfully abrogated by PEI-RFA and the sufficient safety margin was confirmed by computed tomography after the treatment...
  24. ncbi request reprint Detection of increased arterial stiffness in a patient with early stage of large vessel vasculitis by measuring cardio-ankle vascular index
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kagawa, Japan
    Tohoku J Exp Med 219:101-5. 2009
    ..Thus, CAVI may be promising for detection of increased arterial stiffness in patients with large vessel vasculitis in the early stage, in which blood pressure is normal...
  25. ncbi request reprint Coexistence of splenic non-Hodgkin's lymphoma with hepatocellular carcinoma in a patient with chronic hepatitis C
    Takashi Himoto
    Third Department of Internal Medicine, Kagawa University School of Medicine, Kagawa, Japan
    Dig Dis Sci 51:70-6. 2006
  26. ncbi request reprint Percutaneous ethanol and lipiodol injection therapy for hepatocellular carcinoma
    Kazutaka Kurokohchi
    Third Department of Internal Medicine, Kagawa University School of Medicine, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 24:381-7. 2004
    ....
  27. ncbi request reprint Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma
    Hamdy Saad Mohammad
    Department of Gastroenterology and Neurology, Kagawa Medical University School of Medicine, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 33:1157-63. 2008
    ..These data suggest that overexpression and tyrosine phosphorylation of ANXA2 play important roles in the malignant transformation process leading to HCC and are related to the histological grade of HCC...
  28. ncbi request reprint Comparison study of the expressions of myristoylated alanine-rich C kinase substrate in hepatocellular carcinoma, liver cirrhosis, chronic hepatitis, and normal liver
    Tsutomu Masaki
    Third Department of Internal Medicine, Kagawa Medical University, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 26:661-71. 2005
    ....
  29. ncbi request reprint Diffuse large B-cell primary gastric lymphoma treated successfully with the CD20 monoclonal antibody (rituximab): a case with severe liver dysfunction due to liver cirrhosis and hepatocellular carcinoma
    Seiji Nakai
    Third Department of Internal Medicine, Kagawa University School of Medicine, Miki cho, Kita gun, Kagawa 761 0973, Japan
    Oncol Rep 13:1065-8. 2005
    ..This case indicates that monotherapy using only rituximab may be a promising option for the treatment of patients with diffuse large B-cell lymphoma accompanied by severe liver dysfunction...
  30. ncbi request reprint Successful treatment of hypovascular advanced hepatocellular carcinoma with lipiodol-targetting intervention radiology
    Kazutaka Kurokohchi
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    World J Gastroenterol 13:4398-400. 2007
    ..Thus, this case expressing the tremendous effect might give us insight into the effectiveness of the novel combination therapy of PELI and IVR for the treatment of hypovascular HCC...
  31. ncbi request reprint Association of cardio-ankle vascular index with brain natriuretic peptide levels in hypertension
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Japan
    J Atheroscler Thromb 19:255-62. 2012
    ..This study aimed to evaluate the association among CAVIs, plasma BNP levels and left ventricular (LV) hypertrophy and dysfunction in hypertensive patients...
  32. doi request reprint Association between arterial stiffness and pulmonary function in hypertensive patients
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, 1750 1 Miki cho, Kita gun, Kagawa, Japan
    Hypertens Res 35:388-92. 2012
    ..011). The present study indicates that an increased CAVI is independently associated with reduced pulmonary function and increased pulmonary age. Hypertensive patients with high CAVI may need to be monitored for the progression of COPD...
  33. ncbi request reprint Association between high-sensitivity C-reactive protein and left ventricular diastolic function assessed by echocardiography in patients with cardiovascular risk factors
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kagawa, Japan
    Tohoku J Exp Med 223:263-8. 2011
    ..We therefore suggest that hsCRP may be a marker of subclinical LV diastolic dysfunction in patients with cardiovascular risk factors...
  34. doi request reprint A new index of "cardiac age" derived from echocardiography: influence of hypertension and comparison with pulse wave velocity
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kagawa, Japan
    Hypertens Res 31:1573-81. 2008
    ..53, p<0.001). The proposed index of cardiac age can quantitatively assess cardiac morphological changes due to aging and/or hypertension and may be a useful marker of peripheral arterial stiffening...
  35. ncbi request reprint Seasonal variation in estimated glomerular filtration rate based on serum creatinine levels in hypertensive patients
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kagawa, Japan
    Tohoku J Exp Med 224:137-42. 2011
    ..8 ± 9.4 %) than in those without CKD (-7.7 ± 8.3 %) (p = 0.001). In conclusion, careful observation regarding renal function is needed for hypertensive patients with CKD during summer...
  36. doi request reprint Clinical significance of differences between home and clinic systolic blood pressure readings in patients with hypertension
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kagawa, Japan
    J Int Med Res 41:1272-80. 2013
    ..To elucidate the clinical significance of differences between home- and clinic-measured systolic blood pressure (SBP) in patients with treated hypertension, and to assess the correlations between SBPs and arterial stiffness...
  37. pmc A case of plasmablastic lymphoma of the liver without human immunodeficiency virus infection
    Joji Tani
    Joji Tani, Hisaaki Miyoshi, Takako Nomura, Hirohito Yoneyama, Hideki Kobara, Hirohito Mori, Asahiro Morishita, Takashi Himoto, Tsutomu Masaki, Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Kagawa 761 0793, Japan
    World J Gastroenterol 19:6299-303. 2013
    ..The autopsy findings suggested a diagnosis of PBL. To our knowledge, the present case appears to be the first report of PBL with initial presentation of the liver in a patient without HIV infection...
  38. ncbi request reprint Association between urinary 8-hydroxydeoxyguanosine, an indicator of oxidative stress, and the cardio-ankle vascular index in hypertensive patients
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kagawa, Japan
    J Atheroscler Thromb 19:747-55. 2012
    ..This study aimed to evaluate the association between urinary 8-OHdG and the cardioankle vascular index (CAVI) as a marker of arterial stiffness in hypertensive patients...
  39. ncbi request reprint Cardio-ankle vascular index for evaluating immunosuppressive therapy in a patient with aortitis syndrome
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kita gun, Kagawa, Japan
    Tohoku J Exp Med 222:77-81. 2010
    ..In conclusion, CAVI may be a promising marker for evaluating the effectiveness of immunosuppressive therapy in patients with aortitis syndrome...
  40. ncbi request reprint Usefulness of liver infiltrating CD86-positive mononuclear cells for diagnosis of autoimmune hepatitis
    Kazutaka Kurokohchi
    Third Department of Internal Medicine, Kagawa University School of Medicine, Miki cho, Kita gun, Japan
    World J Gastroenterol 12:2523-9. 2006
    ..Analysis of costimulatory molecule expressed on mononuclear cells from the patients with AIH may give us insight into the pathogenic mechanism of hepatocellular damage in AIH...
  41. ncbi request reprint Age-related decrease in inferior vena cava diameter measured with echocardiography
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Miki cho, Kita gun, Kagawa, Japan
    Tohoku J Exp Med 222:141-7. 2010
    ..Therefore, elderly patients with decreased maximum IVC and increased respirophasic IVC collapsibility may need prevention for dehydration...
  42. doi request reprint The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo
    Kiyohito Kato
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Mol Cancer Ther 11:549-60. 2012
    ..The miRNA expression was markedly altered with the treatment of metformin in vitro and in vivo. Various miRNAs altered by metformin also may contribute to tumor growth in vitro and in vivo...
  43. ncbi request reprint Sequential assessment of the intrahepatic expression of epidermal growth factor and transforming growth factor-beta1 in hepatofibrogenesis of a rat cirrhosis model
    Shigeki Kuriyama
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Mol Med 19:317-24. 2007
    ....
  44. doi request reprint Differences between hypertensive and atherosclerotic lesions in retinal arteries assessed by Scheie's classification in hypertensive patients following stroke
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kagawa, Japan
    Clin Exp Hypertens 32:335-40. 2010
    ..This difference between H and S stages of Scheie's classification should be kept in mind when considering the association between retinal microcirculation and large vessel arteriosclerosis...
  45. ncbi request reprint Clinical characteristics of patients with autoimmune hepatitis seropositive for anticentromere antibody
    Takashi Himoto
    Departments of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa, Japan
    Hepatol Res 40:786-92. 2010
    ..Conclusion: These results suggest that the emergence of ACA is not a distinct entity of AIH, despite its clinical characteristics of a significantly higher frequency of concurrent autoimmune diseases and lower serum IgG levels...
  46. ncbi request reprint Correlation of arterial stiffness to left ventricular function in patients with reduced ejection fraction
    Sanae Noguchi
    Department of Clinical Laboratory, Kagawa University, Kagawa, Japan
    Tohoku J Exp Med 225:145-51. 2011
    ..Therefore, hypertensive patients with reduced EF require a stricter regimen for treating arterial stiffness than their counterparts with preserved EF...
  47. ncbi request reprint Association between left ventricular hypertrophy and changes in arterial stiffness during hypertensive treatment
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kagawa, Japan
    Clin Exp Hypertens 36:258-62. 2014
    ..289, p = 0.009) at the start of observation for all 80 patients. It may be difficult to improve arterial stiffness assessed by CAVI during antihypertensive therapy in hypertensive patients with left ventricular hypertrophy...
  48. ncbi request reprint A rare case of hepatocellular carcinoma accompanied by metastasis of a cervical lymph node
    Kiyoyuki Kobayashi
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Japan
    Intern Med 51:381-5. 2012
    ..It is noteworthy, so as not to miss the clinical diagnosis, to remark that metastasis to the cervical lymph node is rarely observed in patients with HCC, and that the metastasis can skip to the regional lymph nodes...
  49. ncbi request reprint Early detection of hypertension in a patient treated with sunitinib by measuring cardio-ankle vascular index
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kagawa, Japan
    Tohoku J Exp Med 218:115-9. 2009
    ..In conclusion, the increase in the CAVI preceded the appearance of sunitinib-induced hypertension. Arterial stiffness assessed by CAVI may be useful for early detection of sunitinib-induced hypertension...
  50. ncbi request reprint Identification of c-Yes expression in the nuclei of hepatocellular carcinoma cells: involvement in the early stages of hepatocarcinogenesis
    Takako Nonomura
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 30:105-11. 2007
    ..In conclusion, nuclear c-Yes expression was found in cancer cells at the early stages of hepatocarcinogenesis, suggesting that nucleus-located c-Yes may be a useful marker to detect early-stage HCC...
  51. pmc Acute superior mesenteric venous thrombosis with advanced gastric cancer: a case report
    Fuminori Goda
    Cancer Center, Kagawa Medical University Hospital, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    Cases J 3:76. 2010
    ..We believe this case provides an important clinical lesson, which is that we should remember that MVT is one of the potential causes of abdominal pain with cancer patients and the thrombosis can be easily identified by US and CT...
  52. ncbi request reprint Effect of the anti-diabetic drug metformin in hepatocellular carcinoma in vitro and in vivo
    Hisaaki Miyoshi
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Int J Oncol 45:322-32. 2014
    ..Our results demonstrate that metformin inhibits the growth of HCC, possibly by inducing G1 cell cycle arrest through the alteration of microRNAs...
  53. ncbi request reprint Multiple hypervascular FNH-like lesions in a patient with no history of alcohol abuse or chronic liver disease
    Joji Tani
    Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Japan
    Intern Med 52:2225-30. 2013
    ..No unpaired arteries were evident. The diagnosis based on the pathology and diagnostic radiology findings was multiple hypervascular focal nodular hyperplasia (FNH)-like lesions with no history of alcohol abuse or chronic liver disease. ..
  54. ncbi request reprint Enlargement of thermal ablation zone by the combination of ethanol injection and radiofrequency ablation in excised bovine liver
    Seishiro Watanabe
    Third Department of Internal Medicine, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 24:279-84. 2004
    ..For a given amount of energy and current administered, ethanol injection caused a better ablation effect, in terms of the size and shape of the ablated zone, than RFA with Radionics and RITA equipment...
  55. ncbi request reprint Cardiac function as assessed by echocardiography in the oldest old > or = 90 years of age
    Hisashi Masugata
    Department of Integrated Medicine, Kagawa University, Kagawa, Japan
    Int Heart J 48:497-504. 2007
    ..The age-related impairment of systolic function as well as diastolic function should be considered when echocardiography is used to evaluate the causes of heart failure in the oldest old...