Hirotaka Watada

Summary

Affiliation: Juntendo University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Repetitive fluctuations in blood glucose enhance monocyte adhesion to the endothelium of rat thoracic aorta
    Kosuke Azuma
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Arterioscler Thromb Vasc Biol 26:2275-80. 2006
  2. ncbi request reprint Glucose fluctuation on the progression of diabetic macroangiopathy--new findings from monocyte adhesion to endothelial cells
    Hirotaka Watada
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo 113 8421, Japan
    Diabetes Res Clin Pract 77:S58-61. 2007
  3. ncbi request reprint Repetitive postprandial hypertriglyceridemia induces monocyte adhesion to aortic endothelial cells in Goto-Kakizaki rats
    Kayoko Motojima
    Department of Medicine, Metabolism and Endocrinology, Juntendo University, School of Medicine, Tokyo, Japan
    Endocr J 55:373-9. 2008
  4. pmc Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4
    Masayuki Arakawa
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Diabetes 59:1030-7. 2010
  5. ncbi request reprint Angiotensin II type 1 receptor blocker reduces monocyte adhesion to endothelial cells in spontaneously hypertensive rats
    Fuki Ikeda
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Endocr J 54:605-12. 2007
  6. ncbi request reprint Strict glycemic control ameliorates the increase of carotid IMT in patients with type 2 diabetes
    Masahiko Kawasumi
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Endocr J 53:45-50. 2006
  7. ncbi request reprint Nateglinide reduces carotid intima-media thickening in type 2 diabetic patients under good glycemic control
    Tomoya Mita
    Department of Medicine, Metabolism, and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Arterioscler Thromb Vasc Biol 27:2456-62. 2007
  8. ncbi request reprint Aldose reductase inhibitor, epalrestat, reduces lipid hydroperoxides in type 2 diabetes
    Chie Ohmura
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Endocr J 56:149-56. 2009
  9. ncbi request reprint Swings in blood glucose levels accelerate atherogenesis in apolipoprotein E-deficient mice
    Tomoya Mita
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 358:679-85. 2007
  10. doi request reprint Miglitol suppresses the postprandial increase in interleukin 6 and enhances active glucagon-like peptide 1 secretion in viscerally obese subjects
    Masayuki Arakawa
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Metabolism 57:1299-306. 2008

Collaborators

Detail Information

Publications83

  1. ncbi request reprint Repetitive fluctuations in blood glucose enhance monocyte adhesion to the endothelium of rat thoracic aorta
    Kosuke Azuma
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Arterioscler Thromb Vasc Biol 26:2275-80. 2006
    ..The aim of this study was to elucidate the effect of repetitive fluctuations in blood glucose concentrations on monocyte adhesion to the aortic endothelium...
  2. ncbi request reprint Glucose fluctuation on the progression of diabetic macroangiopathy--new findings from monocyte adhesion to endothelial cells
    Hirotaka Watada
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo 113 8421, Japan
    Diabetes Res Clin Pract 77:S58-61. 2007
    ..Our data demonstrated that repetitive postprandial fluctuation in glucose concentration evokes monocyte adhesion to endothelial cells that was worse than that induced by stable hyperglycemia in vivo...
  3. ncbi request reprint Repetitive postprandial hypertriglyceridemia induces monocyte adhesion to aortic endothelial cells in Goto-Kakizaki rats
    Kayoko Motojima
    Department of Medicine, Metabolism and Endocrinology, Juntendo University, School of Medicine, Tokyo, Japan
    Endocr J 55:373-9. 2008
    ..This increased monocyte adhesion is associated with the increased aortic expression of adhesion molecules such as ICAM-1, and connecting segment-1 fibronectin...
  4. pmc Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4
    Masayuki Arakawa
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Diabetes 59:1030-7. 2010
    ..The aim of this study was to investigate the effects of GLP-1 on accumulation of monocytes/macrophages on the vascular wall, one of the earliest steps in atherosclerogenesis...
  5. ncbi request reprint Angiotensin II type 1 receptor blocker reduces monocyte adhesion to endothelial cells in spontaneously hypertensive rats
    Fuki Ikeda
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Endocr J 54:605-12. 2007
    ..Also, our date demonstrates that valsartan has a modest beneficial effect on monocyte adhesion to endothelial cells and arterial intima-medial vessel thickening beyond its action as an antihypertensive agent...
  6. ncbi request reprint Strict glycemic control ameliorates the increase of carotid IMT in patients with type 2 diabetes
    Masahiko Kawasumi
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Endocr J 53:45-50. 2006
    ..035 +/- 0.019 vs. 0.036 +/- 0.015 mm, M +/- SEM, p<0.001). These results indicate that further improvement of glycemic control from a good HbA1c value can prevent an increase of IMT in type 2 diabetic patients...
  7. ncbi request reprint Nateglinide reduces carotid intima-media thickening in type 2 diabetic patients under good glycemic control
    Tomoya Mita
    Department of Medicine, Metabolism, and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Arterioscler Thromb Vasc Biol 27:2456-62. 2007
    ..The aim of this study was to investigate the effect of strict glycemic control by nateglinide on common carotid far wall intima-media thickness in type 2 diabetic patients who were already under good glycemic control...
  8. ncbi request reprint Aldose reductase inhibitor, epalrestat, reduces lipid hydroperoxides in type 2 diabetes
    Chie Ohmura
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Endocr J 56:149-56. 2009
    ..Given the importance of measuring lipid hydroperoxides in erythrocytes as an index of oxidative stress, these results highlight the potential usefulness of epalrestat in reducing oxidative stress in type 2 diabetes mellitus...
  9. ncbi request reprint Swings in blood glucose levels accelerate atherogenesis in apolipoprotein E-deficient mice
    Tomoya Mita
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 358:679-85. 2007
    ..This was independent of changes in serum cholesterol level in vivo. Reduction of glucose fluctuation by alpha-glucosidase inhibitor efficiently controlled the progression of atherosclerosis...
  10. doi request reprint Miglitol suppresses the postprandial increase in interleukin 6 and enhances active glucagon-like peptide 1 secretion in viscerally obese subjects
    Masayuki Arakawa
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Metabolism 57:1299-306. 2008
    ..Further studies are needed to elucidate the long-term effects on enhanced GLP-1 secretion and anti-atherosclerosis...
  11. ncbi request reprint Preferable effect of pravastatin compared to atorvastatin on beta cell function in Japanese early-state type 2 diabetes with hypercholesterolemia
    Tomoya Mita
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Endocr J 54:441-7. 2007
    ..In conclusion, our study suggests that pravastatin has a favorable effect on pancreatic beta cell function compared with atorvastatin...
  12. doi request reprint Comparison of effects of olmesartan and telmisartan on blood pressure and metabolic parameters in Japanese early-stage type-2 diabetics with hypertension
    Shiho Nakayama
    Department of Medicine, Metabolism, and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Hypertens Res 31:7-13. 2008
    ..Our results indicate that olmesartan has more potent arterial blood pressure lowering and anti-inflammatory effects than telmisartan...
  13. ncbi request reprint Insulin and nateglinide reduce monocyte adhesion to endothelial cells in Goto-Kakizaki rats exhibiting repetitive blood glucose fluctuation
    Atsuko Tanaka
    Department of Medicine, Metabolism and Endocrinology, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 350:195-201. 2006
    ....
  14. ncbi request reprint Comparison of glycated albumin (GA) and glycated hemoglobin (HbA1c) in type 2 diabetic patients: usefulness of GA for evaluation of short-term changes in glycemic control
    Satomi Takahashi
    Metabolism and Endocrinology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Endocr J 54:139-44. 2007
    ..These results demonstrate that, although unknown influences on GA or HbA1c may exist, GA may be a useful marker for monitoring short-term variations of glycemic control during treatment of diabetic patients...
  15. doi request reprint Impact of insulin resistance on enhanced monocyte adhesion to endothelial cells and atherosclerogenesis independent of LDL cholesterol level
    Tomoya Mita
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 395:477-83. 2010
    ..Decreased insulin signaling in macrophages associated with systemic insulin resistance could be involved, at least in part, in this pathological process...
  16. doi request reprint Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces intimal thickening after vascular injury
    Hiromasa Goto
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 405:79-84. 2011
    ..Our results suggested that exendin-4 reduced intimal thickening after vascular injury at least in part by the suppression of platelet-derived growth factor-induced smooth muscle cells proliferation...
  17. pmc Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance
    Naoki Kumashiro
    Department of Medicine, Metabolism, and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Diabetes 57:2083-91. 2008
    ..However, whether and how the reduction of ROS levels improves insulin resistance remains to be elucidated. The present study was designed to define this mechanism...
  18. ncbi request reprint Long-term efficacy of insulin glargine after switching from NPH insulin as intensive replacement of basal insulin in Japanese diabetes mellitus. Comparison of efficacy between type 1 and type 2 diabetes (JUN-LAN Study 1.2)
    Yoshie Kanazawa
    Department of Medicine, Metabolism and Endocrinology, Juntendo University, School of Medicine, Tokyo, Japan
    Endocr J 54:975-83. 2007
    ....
  19. ncbi request reprint Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on beta-cell function and morphology in db/db mice
    Jiaqing Shao
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 344:1224-33. 2006
    ..Our results showed that candesartan partially prevented deterioration of glucose tolerance by providing protection against progressive beta-cell damage in diabetes...
  20. doi request reprint Masked hypertension, endothelial dysfunction, and arterial stiffness in type 2 diabetes mellitus: a pilot study
    Kageumi Takeno
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Am J Hypertens 25:165-70. 2012
    ..The aim of this study was to assess the relationship between masked hypertension (MHT) and vascular damage in patients with type 2 diabetes...
  21. ncbi request reprint Long-term effect of combination therapy with mitiglinide and once daily insulin glargine in patients who were successfully switched from intensive insulin therapy in short-term study
    Naoki Kumashiro
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Endocr J 54:163-6. 2007
    ..0 +/- 1.0%). In conclusion, mitiglinide and insulin glargine combination therapy maintained fair glycemic control for as long as 6 months in subpopulation of Japanese patients with type 2 diabetes...
  22. ncbi request reprint Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes
    Tomoya Mita
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Atherosclerosis 191:162-7. 2007
    ..067). In summary, this is the first demonstration that administration of purified EPA improves the carotid IMT and the baPWV in patients with type 2 diabetes...
  23. doi request reprint Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents
    Masayuki Arakawa
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 390:809-14. 2009
    ..While GLP-1 enhances proliferation of beta-cells in some diabetic mice models, our results suggest that GLP-1 stimulates beta-cell growth only when expansion of beta-cell mass is required to meet metabolic demands...
  24. ncbi request reprint Association of C-reactive protein with early-stage carotid atherosclerosis in Japanese patients with early-state type 2 diabetes mellitus
    Tomoya Mita
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Hongo, Tokyo, Japan
    Endocr J 53:693-8. 2006
    ....
  25. ncbi request reprint Acarbose, an alpha-glucosidase inhibitor, improves endothelial dysfunction in Goto-Kakizaki rats exhibiting repetitive blood glucose fluctuation
    Kosuke Azuma
    Department of Medicine, Metabolism and Endocrinology, Juntendo University, School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 345:688-93. 2006
    ....
  26. ncbi request reprint Effects of diet-induced moderate weight reduction on intrahepatic and intramyocellular triglycerides and glucose metabolism in obese subjects
    Fumihiko Sato
    Department of Medicine, Metabolism, and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    J Clin Endocrinol Metab 92:3326-9. 2007
    ..Although moderate weight reduction is recommended as primary therapy of metabolic syndrome, little information is known regarding metabolic changes associated with moderate weight reduction in nondiabetic obese subjects...
  27. ncbi request reprint Calcium channel blocker, azelnidipine, reduces lipid hydroperoxides in patients with type 2 diabetes independent of blood pressure
    Chie Ohmura
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Endocr J 54:805-11. 2007
    ..Our data confirm the usefulness of lipid hydroperoxides in erythrocyte membrane as a marker of oxidative stress in vivo, and indicate that azelnidipine has a unique antioxidative property in human...
  28. ncbi request reprint N-(carboxymethyl)valine residues in hemoglobin (CMV-Hb) reflect accumulation of oxidative stress in diabetic patients
    Satoshi Shimada
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Diabetes Res Clin Pract 69:272-8. 2005
    ..The CMV-Hb level was decreased by antioxidant therapy, whereas HbA1c did not change. These results demonstrate that CMV-Hb may be a useful marker for accumulation of oxidative stress in diabetic patients...
  29. ncbi request reprint Characteristics of Japanese subjects who progress from normal to impaired glucose tolerance. Longitudinal study excluding changes in body weight
    Yasuhiro Igarashi
    Department of Medicine, Metabolism and Endocrinology, Juntendo University, School of Medicine, Tokyo
    Endocr J 52:683-9. 2005
    ..Plasma glucose at 30-120 minutes and serum insulin level at 120 minutes after glucose load are potentially significant predictors of progression from NGT to IGT even in subjects who do not show increase of body weight...
  30. doi request reprint Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet
    Chie Ebato
    Department of Medicine, Endocrinology, and Metabolism, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Cell Metab 8:325-32. 2008
    ..The results also identified a unique role for inductive autophagy as an adaptive response of beta cells in the presence of insulin resistance induced by high-fat diet...
  31. doi request reprint Effects of changes in basal/total daily insulin ratio in type 2 diabetes patients on intensive insulin therapy including insulin glargine (JUN-LAN Study 6)
    Motoyuki Tamaki
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo, Tokyo 113 8421, Japan
    Diabetes Res Clin Pract 81:e1-3. 2008
    ..Our results suggest that adequate supplementation of basal insulin may be important for maximum effect of bolus insulin even in Japanese who have serious defect in postprandial rapid insulin secretion...
  32. doi request reprint Exercise-induced enhancement of insulin sensitivity is associated with accumulation of M2-polarized macrophages in mouse skeletal muscle
    Shin ichi Ikeda
    Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113 8421, Japan Sportology Center, Juntendo University Graduate School of Medicine, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 441:36-41. 2013
    ....
  33. ncbi request reprint Anti-oxidative effect of fluvastatin in hyperlipidemic type 2 diabetic patients
    Shinnya Miwa
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Hongo, Tokyo, Japan
    Endocr J 52:259-64. 2005
    ..Our data demonstrated that fluvastatin has a unique anti-oxidative effect in patients with type 2 diabetes and hyperlipidemia, compared with other statins...
  34. ncbi request reprint Lack of evident atherosclerosis despite multiple risk factors in glycogen storage disease type 1a with hyperadiponectinemia
    Motoyuki Tamaki
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Metabolism 56:1402-4. 2007
    ..Although further studies are needed, hyperadiponectinemia in addition to hypoinsulinemia might explain at least in part the lack of evident atherosclerosis in patients with GSD1a...
  35. ncbi request reprint Combined expression of transcription factors induces AR42J-B13 cells to differentiate into insulin-producing cells
    Takeshi Ogihara
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Endocr J 55:691-8. 2008
    ..1 or MafA induces AR42J-B13 cells to differentiate into insulin-producing cells, supporting the use of these cells as a model system for studying beta-cell differentiation in vitro...
  36. doi request reprint Presence of alpha-smooth muscle actin-positive endothelial cells in the luminal surface of adult aorta
    Kosuke Azuma
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 380:620-6. 2009
    ..Our findings indicate the existence of alpha-smooth muscle actin-positive endothelial cells in adult aortic endothelium and the possible association with progression of atherosclerosis...
  37. doi request reprint Anagliptin, a DPP-4 inhibitor, suppresses proliferation of vascular smooth muscles and monocyte inflammatory reaction and attenuates atherosclerosis in male apo E-deficient mice
    Nasib Ervinna
    Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Endocrinology 154:1260-70. 2013
    ..These results indicated that the anti-atherosclerotic effect of anagliptin is mediated, at least in part, through its direct inhibition of SMC proliferation and inflammatory reaction of monocytes...
  38. pmc Combination of the Framingham risk score and carotid intima-media thickness improves the prediction of cardiovascular events in patients with type 2 diabetes
    Michiko Yoshida
    Department of Medicine, Metabolism, and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Diabetes Care 35:178-80. 2012
    ....
  39. doi request reprint Short-term effects of dietary fat on intramyocellular lipid in sprinters and endurance runners
    Yoshifumi Tamura
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Metabolism 57:373-9. 2008
    ..These phenotypic and regional differences might be explained by differences in type of exercise training and muscle fiber composition...
  40. doi request reprint Normal islet vascularization is dispensable for expansion of beta-cell mass in response to high-fat diet induced insulin resistance
    Yukiko Toyofuku
    Department of Medicine, Metabolism and Endocrinology, Juntendo University, Hongo, Bunkyo ku, Tokyo, Japan
    Biochem Biophys Res Commun 383:303-7. 2009
    ..Thus, normal islet vascularization does not seem to be essential for expansion of beta cell mass in response to insulin resistance...
  41. doi request reprint Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway
    Koji Komiya
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 401:561-7. 2010
    ..Considered together, our study suggested that FFA stimulated functional autophagy possibly through the PKR-JNK1 pathway independent of ER or oxidative stress...
  42. ncbi request reprint Therapeutic efficacy of mitiglinide combined with once daily insulin glargine after switching from multiple daily insulin regimen of aspart insulin and glargine in patients with type 2 diabetes mellitus
    Tomoaki Yoshihara
    Department of Medicine, Metabolism and Endocrinology, Juntendo University, School of Medicine, Tokyo, Japan
    Endocr J 53:67-72. 2006
    ..The long-term effects of such treatment need to be established in future studies...
  43. doi request reprint Prevalence of abnormal glucose metabolism and insulin resistance among subtypes of ischemic stroke in Japanese patients
    Takao Urabe
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Stroke 40:1289-95. 2009
    ..The purpose was to assess the prevalence of disorders of glucose metabolism and insulin resistance in Japanese ischemic stroke patients with no history of diabetes by performing 75-gram oral glucose tolerance test (OGTT)...
  44. doi request reprint Association between atherosclerosis and newly classified chronic kidney disease stage for Japanese patients with type 2 diabetes
    Risako Yamamoto
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Diabetes Res Clin Pract 84:39-45. 2009
    ..5% vs. 0.6%). In conclusion, diabetic patients with eGFR<75 and/or UACR > or =20 might be a high-risk population for CVD...
  45. ncbi request reprint Management of home blood pressure by amlodipine combined with angiotensin II receptor blocker in type 2 diabetes
    Katsumi Miyauchi
    Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan
    Circ J 76:2159-66. 2012
    ..The objective of the study was to evaluate the effect of amlodipine combined therapy on home blood pressure (HBP) useful for management of hypertension...
  46. ncbi request reprint Effects of diet and exercise on muscle and liver intracellular lipid contents and insulin sensitivity in type 2 diabetic patients
    Yoshifumi Tamura
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Clin Endocrinol Metab 90:3191-6. 2005
    ..These effects were evident despite a small decrease in body fat and were observed independently of fasting FFA levels...
  47. doi request reprint Autophagy in health and disease. 4. The role of pancreatic beta-cell autophagy in health and diabetes
    Yoshio Fujitani
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Faculty of Medicine, Tokyo, Japan
    Am J Physiol Cell Physiol 299:C1-6. 2010
    ..In this review, we describe the crucial roles of autophagy in normal function of beta-cells and discuss how dysfunction of the autophagic machinery could lead to the development of diabetes mellitus...
  48. ncbi request reprint Glucose homeostasis in a diabetic patient during liver transplantation: a case report
    Masayuki Arakawa
    Department of Medicine, Metabolism and Endocrinology, Juntendo University, School of Medicine, Tokyo, Japan
    Endocr J 54:819-23. 2007
    ..We analyzed the levels of blood glucose, insulin and various other hormones during the anhepatic phase. This could be the first report on glucose homeostasis during the anhepatic phase in a diabetic patient...
  49. ncbi request reprint Acute onset and worsening of diabetes concurrent with administration of statins
    Chie Ohmura
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Endocr J 52:369-72. 2005
    ..In the general population, statin does not seem to have critical adverse effects on glucose tolerance, but it may uncommonly modify the natural course of the development of diabetes in certain patients...
  50. doi request reprint Beneficial effects of vildagliptin combined with miglitol on glucose tolerance and islet morphology in diet-controlled db/db mice
    Keita Ishibashi
    Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 440:570-5. 2013
    ....
  51. doi request reprint Exendin-4 improves β-cell function in autophagy-deficient β-cells
    Hiroko Abe
    or Toyoyoshi Uchida, M D, Ph D, Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan or
    Endocrinology 154:4512-24. 2013
    ..In addition, exendin-4 prevents apoptosis and increases the proliferation of β-cells associated with autophagy deficiency, also without altering the autophagic machinery in β-cells. ..
  52. doi request reprint Preliminary report: mitochondrial DNA 5178 polymorphism in male elite Japanese endurance runners
    Yoshifumi Tamura
    Department of Medicine, Metabolism and Endocrinology, School of Medicine, Juntendo University, Tokyo 113 842, Japan
    Metabolism 59:62-3. 2010
    ..2%) of the m.5178C genotype than control subjects (52.7%). The-m.5178C genotype may be favorable for performance in elite endurance runners...
  53. ncbi request reprint Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells
    Toyoyoshi Uchida
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1, Tokyo 113 8421, Japan
    J Biol Chem 282:2707-16. 2007
    ..We conclude that PKCdelta plays a non-redundant role in glucose-stimulated insulin secretion. The impaired insulin secretion in PKCdelta null mice is associated with reduced phosphorylation of Munc18-1...
  54. doi request reprint Downregulation of ZnT8 expression in pancreatic β-cells of diabetic mice
    Motoyuki Tamaki
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Bunkyo ku, Tokyo, Japan
    Islets 1:124-8. 2009
    ..As a conclusion, ZnT8 is expressed in multiple lineages of endocrine cells in the pancreas. Our findings suggest that downregulation of ZnT8 may be associated with impaired function of β-cells in diabetes...
  55. ncbi request reprint Superior thyroid artery mean peak systolic velocity for the diagnosis of thyrotoxicosis in Japanese patients
    Toyoyoshi Uchida
    Department of Medicine, Juntendo University, Graduate School, Bunkyo ku, Tokyo, Japan
    Endocr J 57:439-43. 2010
    ..The optimal sensitivity and specificity were 83.7% and 92.3%, respectively, using 45 cm/sec as the cutoff value. In conclusion measurement of STA-PSV by ultrasonography is useful for the diagnosis of thyrotoxicosis in Japanese patients...
  56. ncbi request reprint [NEMOes, a new method to evaluate early atherosclerosis in rodent model]
    Hirotaka Watada
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine
    Nihon Rinsho 64:2165-75. 2006
    ..NEMOes may be a promising tool for understanding the pathophysiology of atherosclerosis...
  57. doi request reprint Efficacy and safety of modified Yale insulin infusion protocol in Japanese diabetic patients after open-heart surgery
    Motoyuki Tamaki
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Diabetes Res Clin Pract 81:296-302. 2008
    ..In conclusion, our modified Yale insulin infusion protocol is effective and safe for tight blood glucose control in Japanese diabetic patients after open-heart surgery...
  58. doi request reprint Carotid intima-media thickness progression predicts cardiovascular events in Japanese patients with type 2 diabetes
    Kaede Ishikawa Okayama
    Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Diabetes Res Clin Pract 101:286-92. 2013
    ....
  59. ncbi request reprint Effect of cilostazol, a phosphodiesterase inhibitor, on carotid IMT in Japanese type 2 diabetic patients
    Naomi Mitsuhashi
    Department of Medicine, Metabolism and Endocrinology, Juntendo University, Tokyo 113 8421, Japan
    Endocr J 51:545-50. 2004
    ..These results indicate that cilostazol therapy can attenuate the increase of carotid artery IMT in Japanese subjects with type 2 diabetes...
  60. doi request reprint IRS-2 deficiency in macrophages promotes their accumulation in the vascular wall
    Tomoya Mita
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 415:545-50. 2011
    ..These results suggest a role for insulin resistance in macrophages in early atherosclerogenesis...
  61. doi request reprint β-cell autophagy: A novel mechanism regulating β-cell function and mass: Lessons from β-cell-specific Atg7-deficient mice
    Yoshio Fujitani
    Department of Medicine, Metabolism and Endocrinology, Center for Therapeutic Innovations in Diabetes, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Islets 1:151-3. 2009
    ..We will also discuss the role of inductive autophagy as a crucial element of stress responses to protect β-cells, which supports compensatory β-cell growth in the presence of insulin resistance...
  62. ncbi request reprint Role of VEGF-A in pancreatic beta cells
    Hirotaka Watada
    Department of Medicine, Metabolism and Endocrinology, Faculty of Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Endocr J 57:185-91. 2010
    ..These data indicate that the roles of VEGF-A and islet vasculature in the regulation of beta cell mass depends on the stimulus for the islets...
  63. ncbi request reprint Activin A-induced expression of PAX4 in AR42J-B13 cells involves the increase in transactivation of E47/E12
    Rei Kanno
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Biochim Biophys Acta 1759:44-50. 2006
    ..Our results suggest that activin A enhances PAX4 expression by enhanced transactivation of E47/E12 proteins and might result in a cumulative transactivation of the promoter...
  64. ncbi request reprint [Mechanism of progression of atherosclerosis in patients with impaired glucose tolerance (IGT)]
    Hirotaka Watada
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine
    Nihon Rinsho 63:101-6. 2005
  65. ncbi request reprint The role of autophagy in pancreatic beta-cell and diabetes
    Yoshio Fujitani
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Autophagy 5:280-2. 2009
    ..Autophagy also serves as a crucial element of stress responses to protect beta-cells under insulin-resistant states. Impairment of autophagic machinery could thus predispose individuals to type 2 diabetes...
  66. ncbi request reprint [Protective effects of incretin on atherosclerosis]
    Tomoya Mita
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine
    Nihon Rinsho 69:831-5. 2011
    ....
  67. pmc Glucose monitoring after fruit peeling: pseudohyperglycemia when neglecting hand washing before fingertip blood sampling: wash your hands with tap water before you check blood glucose level
    Takahisa Hirose
    Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Diabetes Care 34:596-7. 2011
    ..To examine whether hand contamination with fruit results in a false blood glucose (BG) reading using capillary fingertip blood sample...
  68. ncbi request reprint Fulminant emphysematous pyelonephritis (EPN) in a diabetic patient suspected of having multiple tumors
    Junko Sato
    Division of Metabolism and Endocrinology, Department of Internal Medicine, Juntendo Urayasu Hospital, Urayasu
    Intern Med 49:2317-20. 2010
    ..This case highlights the importance of carefully managing infection in diabetic patients, and it may contribute to clarifying the pathogenesis of EPN...
  69. ncbi request reprint A new En face method is useful to quantitate endothelial damage in vivo
    Kosuke Azuma
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 309:384-90. 2003
    ..In conclusion, the present modified En face immunostaining method may be a promising tool for understanding the pathophysiology of atherosclerosis...
  70. ncbi request reprint Accumulation of somatic mutation in mitochondrial DNA and atherosclerosis in diabetic patients
    Takashi Nomiyama
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Ann N Y Acad Sci 1011:193-204. 2004
    ..In conclusion, diabetes accelerates the accumulation of the somatic A3243G mutation in mitochondrial DNA, and this somatic mutation may be a marker for the duration of diabetes and atherosclerosis...
  71. ncbi request reprint Reduction of insulin-stimulated glucose uptake by peroxynitrite is concurrent with tyrosine nitration of insulin receptor substrate-1
    Takashi Nomiyama
    Department of Medicine, Metabolism and Endocrinology, Juntendo University, School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 320:639-47. 2004
    ..Our results suggest that peroxynitrite reduces the IRS-1 protein level and decreases phosphorylation of IRS-1 concurrent with nitration of its tyrosine residues...
  72. ncbi request reprint Responsiveness of insulin-induced cardiac sympathetic nerve activation associates with blood pressure regulation in diabetics
    Miki Takagi
    Department of Medicine, Metabolism, and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Am J Physiol Endocrinol Metab 284:E1022-6. 2003
    ..02) but not with GIR. These data demonstrate that an acute insulin load stimulates cardiac SNA, and insulin sensitivity in the regulation of SNA may be associated with BP regulation independently of peripheral insulin sensitivity...
  73. ncbi request reprint RANTES promoter genotype is associated with diabetic nephropathy in type 2 diabetic subjects
    Kunihiro Nakajima
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Diabetes Care 26:892-8. 2003
    ..To evaluate the effect of RANTES gene promoter polymorphism and RANTES receptor (CCR5 gene) promoter polymorphism on diabetic nephropathy in Japanese type 2 diabetic subjects...
  74. ncbi request reprint Efficacy and safety of once daily gliclazide (20 mg/day) compared with nateglinide
    Shinnya Miwa
    Department of Medicine, Metabolism and Endocrinology, Juntendo University, School of Medicine, Tokyo, Japan
    Endocr J 51:393-8. 2004
    ..Compared with the regular dose of nateglinide, 20 mg/day of gliclazide achieved modestly better glycemic control with an increased frequency of hypoglycemia in diabetic patients with relatively good glycemic control...
  75. ncbi request reprint [Disorder of vascular smooth muscle cell and platelet function in diabetes]
    Hiromasa Goto
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Faculty of Medicine
    Nihon Rinsho 68:833-8. 2010
    ..However, in JPAD trial, the use of aspirin failed to show the primary preventive effect for cardiovascular events. Further prospective studies to elucidate the effect of anticoagulant for the prevention of atherosclerosis are needed...
  76. ncbi request reprint Neurogenin 3 is a key transcription factor for differentiation of the endocrine pancreas
    Hirotaka Watada
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Endocr J 51:255-64. 2004
  77. ncbi request reprint p38 MAPK is involved in activin A- and hepatocyte growth factor-mediated expression of pro-endocrine gene neurogenin 3 in AR42J-B13 cells
    Takeshi Ogihara
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Biol Chem 278:21693-700. 2003
    ....
  78. ncbi request reprint 2-Methoxyestradiol reduces monocyte adhesion to aortic endothelial cells in ovariectomized rats
    Atsuko Kurokawa
    Department of Gynecology, Juntendo University, School of Medicine, Tokyo, Japan
    Endocr J 54:1027-31. 2007
    ..Our data suggested that 2-ME mediates the anti-atherosclerotic actions of estradiol at least in part by preventing monocyte adhesion to the aortic endothelium...
  79. ncbi request reprint Probucol preserves pancreatic beta-cell function through reduction of oxidative stress in type 2 diabetes
    Shin ichi Gorogawa
    Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka Pref, Japan
    Diabetes Res Clin Pract 57:1-10. 2002
    ..05); glucose, 44.6+/-2.4 vs. 35.2+/-2.6 mmol/l (120 min, at 16 weeks; P<0.05). Thus, our present observations demonstrate the potential usefulness of probucol for treatment of type 2 diabetes...
  80. ncbi request reprint Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice
    Shin ichi Gorogawa
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 319:1159-70. 2004
    ..Our present observations demonstrate a unique role of STAT3 in maintaining glucose-mediated early-phase insulin secretion and normal islet morphology...
  81. doi request reprint Insulin exocytosis in Goto-Kakizaki rat beta-cells subjected to long-term glinide or sulfonylurea treatment
    Junko Kawai
    Department of Biochemistry, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    Biochem J 412:93-101. 2008
    ..We conclude that treatment of GK rats with nateglinide and glibenclamide varies in long-term effects on beta-cell functions; nateglinide treatment appears overall to be more beneficial...
  82. ncbi request reprint Hypoglycemia following a nateglinide overdose in a suicide attempt
    Shiho Nakayama
    Diabetes Care 28:227-8. 2005
  83. ncbi request reprint PAX6 mutation as a genetic factor common to aniridia and glucose intolerance
    Tetsuyuki Yasuda
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    Diabetes 51:224-30. 2002
    ..Taken together, our present observations suggest that heterozygous mutations in the PAX6 gene can induce eye anomaly and glucose intolerance in individuals harboring these mutations...