Kazuyoshi Takeda

Summary

Affiliation: Juntendo University School of Medicine
Country: Japan

Publications

  1. pmc Critical contribution of liver natural killer T cells to a murine model of hepatitis
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Proc Natl Acad Sci U S A 97:5498-503. 2000
  2. ncbi request reprint Targeting death-inducing receptors in cancer therapy
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    Oncogene 26:3745-57. 2007
  3. pmc Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
    Proc Natl Acad Sci U S A 105:10895-900. 2008
  4. ncbi request reprint TWEAK mediates anti-tumor effect of tumor-infiltrating macrophage
    Yuki Kaduka
    Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 331:384-90. 2005
  5. pmc Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University, School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    J Exp Med 195:161-9. 2002
  6. ncbi request reprint Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Nat Med 7:94-100. 2001
  7. ncbi request reprint Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Cell Immunol 214:194-200. 2001
  8. ncbi request reprint TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bukyou ku, Tokyo 113 8421, Japan
    Blood 105:2082-9. 2005
  9. ncbi request reprint Combination antibody-based cancer immunotherapy
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Cancer Sci 98:1297-302. 2007
  10. pmc Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bukyou ku, Tokyo 113 8421, Japan
    J Exp Med 199:437-48. 2004

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. pmc Critical contribution of liver natural killer T cells to a murine model of hepatitis
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Proc Natl Acad Sci U S A 97:5498-503. 2000
    ..These results implicated FasL expression on liver NKT cells in the pathogenesis of Con A-induced hepatitis, suggesting a similar pathogenic role in human liver diseases such as autoimmune hepatitis...
  2. ncbi request reprint Targeting death-inducing receptors in cancer therapy
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    Oncogene 26:3745-57. 2007
    ....
  3. pmc Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
    Proc Natl Acad Sci U S A 105:10895-900. 2008
    ..Thus, TRAIL/DR5-mediated apoptosis may substantially contribute to chronic cholestatic disease, particularly primary sclerosing cholangitis...
  4. ncbi request reprint TWEAK mediates anti-tumor effect of tumor-infiltrating macrophage
    Yuki Kaduka
    Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 331:384-90. 2005
    ..On the other hand, TWEAK expression in tumor cells had no significant effect on subcutaneous tumor growth. These results indicate that TWEAK mediates anti-tumor effect of macrophages in vivo...
  5. pmc Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University, School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    J Exp Med 195:161-9. 2002
    ..Moreover, development of spontaneous tumors in p53(+/-) mice was also promoted by neutralization of TRAIL. These results indicated a substantial role of TRAIL as an effector molecule that eliminates developing tumors...
  6. ncbi request reprint Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Nat Med 7:94-100. 2001
    ..These findings provide the first evidence for the physiological function of TRAIL as a tumor suppressor...
  7. ncbi request reprint Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Cell Immunol 214:194-200. 2001
    ..These results suggested a substantial role of TRAIL as the effector molecule that eliminates subcutaneously developing TRAIL-sensitive tumors...
  8. ncbi request reprint TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bukyou ku, Tokyo 113 8421, Japan
    Blood 105:2082-9. 2005
    ..This study is the first to describe the concomitant maturation of NK cell effector function with surface phenotype in vivo and implies an important defense role for NK cell TRAIL in the developing immune system...
  9. ncbi request reprint Combination antibody-based cancer immunotherapy
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Cancer Sci 98:1297-302. 2007
    ..The authors believe that this rational activation and inhibition of key points in the immune response can be an effective strategy to apply in human cancer patients...
  10. pmc Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bukyou ku, Tokyo 113 8421, Japan
    J Exp Med 199:437-48. 2004
    ....
  11. ncbi request reprint The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo
    Hisaya Akiba
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 175:2340-8. 2005
    ..These results indicated that the ICOS/B7RP-1 interaction plays an essential role in the development of CXCR5+ T(FH) cells in vivo...
  12. pmc IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2
    Tsuyoshi Ota
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Blood 106:184-92. 2005
    ....
  13. doi request reprint Combination therapy of established tumors by antibodies targeting immune activating and suppressing molecules
    Kazuyoshi Takeda
    Department of Immunology, Biomedical Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 184:5493-501. 2010
    ..Thus, the blockade of the CTLA-4-mediated inhibitory signal in tumor infiltrating CTL may be the most effective strategy to augment the effect of immune therapies that generate tumor-specific CTL...
  14. ncbi request reprint Eradication of established tumors in mice by a combination antibody-based therapy
    Tomoyasu Uno
    Department of Immunology, Juntendo University School of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
    Nat Med 12:693-8. 2006
    ..These results in mice indicate that a rational monoclonal antibody-based therapy that both causes tumor-cell apoptosis through DR5 and activates T cells may be an effective strategy for cancer immunotherapy in humans...
  15. pmc NKG2A inhibits invariant NKT cell activation in hepatic injury
    Toshihiko Kawamura
    Department of Immunology, Niigata University School of Medicine, Niigata, Japan
    J Immunol 182:250-8. 2009
    ..Overall, these results indicated that a NKG2A-mediated signal negatively regulates iNKT cell activation and hepatic injury...
  16. pmc Activation of natural killer T cells by alpha-galactosylceramide impairs DNA vaccine-induced protective immunity against Trypanosoma cruzi
    Yasushi Miyahira
    Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Infect Immun 71:1234-41. 2003
    ..cruzi. Our results, in contrast to previous reports demonstrating the protective roles of NK T cells against other infectious agents, suggest that these cells might even exhibit adverse effects on vaccine-mediated protective immunity...
  17. doi request reprint Contribution of B7RP-1/ICOS co-stimulation to lethal acute GVHD
    Junya Fujimura
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Transplant 14:540-8. 2010
    ....
  18. doi request reprint IFN-γ production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Leukoc Biol 90:777-85. 2011
    ..Our results demonstrate that IFN-γ production from lung resident NK cells is a key response in the natural resistance to the experimental lung metastasis of NK cell-resistant tumor cells...
  19. ncbi request reprint TRAIL and its receptors as targets for cancer therapy
    Hideo Yagita
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Cancer Sci 95:777-83. 2004
    ..In this review, we summarize recent knowledge about TRAIL and its receptors as promising targets for cancer therapy...
  20. ncbi request reprint Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells
    Toshiro Futagawa
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Int Immunol 14:275-86. 2002
    ..Moreover, IL-12 production by anti-CD40-stimulated DC was partially inhibited by TKS-1. These results suggest that 4-1BB expressed on DC may be involved in DC activation through DC--tumor interaction and DC--DC interaction...
  21. ncbi request reprint ICOS costimulates invariant NKT cell activation
    Hiroshi Kaneda
    Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 327:201-7. 2005
    ..Moreover, blockade of both B7RP-1-ICOS and CD80/86-CD28 interactions mostly abolished the alpha-GalCer-induced immune responses. These findings indicate that iNKT cell activation is regulated by CD28 and IOCS independently...
  22. doi request reprint Innate immune responses involving natural killer and natural killer T cells promote liver regeneration after partial hepatectomy in mice
    Satoko Hosoya
    Dept of Gastroenterology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Am J Physiol Gastrointest Liver Physiol 304:G293-9. 2013
    ..NK and NKT cells most likely upregulate TNF-α, IL-6/STAT3, and HGF in a coordinate fashion, thus promoting normal regenerative responses in the liver...
  23. doi request reprint TIM-1 signaling in B cells regulates antibody production
    Juan Ma
    Department of Immunology, Juntendo University, 2 1 1 Hongo, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 406:223-8. 2011
    ..These results suggest that TIM-1 signaling in B cells augments antibody production by enhancing B cell proliferation and differentiation...
  24. ncbi request reprint Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly inhibits activities of natural killer cells, cytotoxic T lymphocytes and lymphokine-activated killer cells via the Fas-ligand/Fas pathway in perforin-knockout (PKO) mice
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Toxicology 204:41-50. 2004
    ..Taken together, these findings indicate that the DDVP-induced inhibition of NK, LAK and CTL activities in PKO mice is mediated by the impairment of the FasL/Fas pathway...
  25. pmc Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells
    Yuko Kojima
    Laboratory of Biomedical Imaging Research, Biomedical Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Biol Chem 286:43383-93. 2011
    ....
  26. ncbi request reprint Blastocyst MHC, a putative murine homologue of HLA-G, protects TAP-deficient tumor cells from natural killer cell-mediated rejection in vivo
    Atsushi Tajima
    Department of Immunology and Obstetrics and Gynecology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 171:1715-21. 2003
    ..These results suggested a role for blastocyst MHC in protecting TAP-deficient trophoblasts and tumor cells from NK cell attack in vivo...
  27. pmc Interleukin-12- and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill
    Eri Yuminamochi
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    Immunology 121:197-206. 2007
    ..These results clearly demonstrated that A. blazei and ABPC augmented NK cell activation through IL-12-mediated IFN-gamma production...
  28. pmc Interleukin (IL)-4 promotes T helper type 2-biased natural killer T (NKT) cell expansion, which is regulated by NKT cell-derived interferon-gamma and IL-4
    Akira Iizuka
    Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Immunology 123:100-7. 2008
    ..This finding suggests that effective expansion of NKT cells requires Th2-biased culture conditions...
  29. ncbi request reprint Roles of PU.1 in monocyte- and mast cell-specific gene regulation: PU.1 transactivates CIITA pIV in cooperation with IFN-gamma
    Tomonobu Ito
    Atopy Allergy Research Center, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Int Immunol 21:803-16. 2009
    ..1 transfectants indicate that enforced PU.1 suppresses mast cell-specific gene expression through these transcription factors...
  30. ncbi request reprint CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells
    H Akiba
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 162:7058-66. 1999
    ..These results indicated that OX40L and CD70 expressed on surface Ig- and CD40-stimulated B cells can provide CD28-independent costimulatory signals to T cells...
  31. doi request reprint Long-term Vaccination with Multiple Peptides Derived from Cancer-Testis Antigens Can Maintain a Specific T-cell Response and Achieve Disease Stability in Advanced Biliary Tract Cancer
    Atsushi Aruga
    Department of Gastroenterological Surgery Institute of Advanced Biomedical Engineering and Science, Tokyo, Japan
    Clin Cancer Res 19:2224-31. 2013
    ....
  32. ncbi request reprint Runx proteins are involved in regulation of CD122, Ly49 family and IFN-gamma expression during NK cell differentiation
    Shin ichiro Ohno
    Department of Immunology, Tokai University School of Medicine, Boseidai, Isehara, Kanagawa 259 1193, Japan
    Int Immunol 20:71-9. 2008
    ..These findings suggest that Runx proteins, especially Runx3, play multiple roles in NK cell differentiation...
  33. ncbi request reprint Natural killer cell lytic activity and CD56(dim) and CD56(bright) cell distributions during and after intensive training
    Masatoshi Suzui
    School of Business Administration, Meiji University, Suginami, Tokyo, Japan, 168 8555
    J Appl Physiol (1985) 96:2167-73. 2004
    ..These results suggest that heavy training can decrease total NK cell cytotoxicity as well as lytic units per NK cell. Such effects may reflect in part an increase in the proportion of circulating NK cells with a low cytotoxicity...
  34. ncbi request reprint Critical role of NK1+ T cells in IL-12-induced immune responses in vivo
    T Kawamura
    Department of Immunology, Niigata University School of Medicine, Japan
    J Immunol 160:16-9. 1998
    ..These results indicate that NK1+ T cells play a critical role in IL-12-induced production of IFN-gamma to initiate Th1 immune responses and as IL-12-induced cytotoxic effector cells to initiate antitumor immunity...
  35. doi request reprint Functional roles of tumor necrosis factor-related apoptosis-inducing ligand-DR5 interaction in B16F10 cells by activating the nuclear factor-κB pathway to induce metastatic potential
    Kei Takahashi
    Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    Cancer Sci 104:558-62. 2013
    ..These findings may imply a contrary role for the TRAIL-DR5 pathway in the inflammatory tumor microenvironment, in its ability to induce the metastatic potential of B16F10 melanoma cells instead of inducing apoptosis...
  36. doi request reprint Altered expression and function of hepatic natural killer T cells in obese and diabetic KK-A(y) mice
    Hisafumi Yamagata
    Departments of Gastroenterology Immunology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Hepatol Res 43:276-88. 2013
    ....
  37. pmc Natural killer T cells suppress zymosan A-mediated granuloma formation in the liver by modulating interferon-γ and interleukin-10
    Takahiro Kobayashi
    Department of Immunology, Niigata University School of Medicine, Niigata, Japan
    Immunology 136:86-95. 2012
    ..Also, zymosan A increased interleukin-10 production in WT mice, which suppresses IFN-γ production. Taken together, these results suggest that NKT cells in the liver have the potential to suppress zymosan A-mediated granuloma formation...
  38. doi request reprint Organ microenvironment plays significant roles through Fas ligand in vaccine-induced CD4(+) T cell dependent suppression of tumor growth at the orthotopic site
    Daisuke Sugiura
    Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    Cancer Sci 101:1965-9. 2010
    ..In the cecum, FasL was associated with intratumoral CD11b(+) cells, which are likely to be responsible for vaccine-induced tumor suppression. The T cell response to MUC1 was not influenced by the gld/gld status...
  39. doi request reprint Early activation and interferon-γ production of tumor-infiltrating mature CD27 high natural killer cells
    Yoshihiro Hayakawa
    Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    Cancer Sci 102:1967-71. 2011
    ..This work implicates the importance of IFN-γ as a positive regulatory factor for NK cell recruitment into the tumor microenvironment and an effective antitumor immune effector response...
  40. pmc Coadministration of an interleukin-12 gene and a Trypanosoma cruzi gene improves vaccine efficacy
    Masaharu Katae
    Department of Respiratory Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Infect Immun 70:4833-40. 2002
    ..cruzi infection. These results reinforced the utility of immunomodulatory adjuvants such as IL-12 gene for eliciting protective immunity against intracellular parasites by DNA vaccination...
  41. doi request reprint Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation
    Masafumi Nakayama
    Department of Immunology, Biomedical Research Center, Juntendo University School of Medicine, Tokyo, Japan
    Blood 113:3821-30. 2009
    ..These results indicate a crucial role for Tim-3 in phagocytosis of apoptotic cells and cross-presentation, which may be linked to peripheral tolerance...
  42. ncbi request reprint [Current advances and expectations in tumor immunology]
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
    Hum Cell 14:159-63. 2001
    ..Presented findings provide the first evidence for the physiological function of TRAIL as a tumor suppressor...
  43. pmc A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis
    Arnaud Couzinet
    Departments of Immunology and Molecular Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:2556-61. 2008
    ..Thus, these findings reveal a cell-type-specific function for IRF5 in the complex regulatory mechanism of death-receptor-induced apoptosis...
  44. doi request reprint Antitumor activity of anti-C-ERC/mesothelin monoclonal antibody in vivo
    Koichi Inami
    Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
    Cancer Sci 101:969-74. 2010
    ..Thus, 22A31 induced NK cell-mediated ADCC and exerted antitumor activity in vivo. 22A31 could have potential as a therapeutic tool to treat C-ERC/mesothelin-expressing cancers including mesothelioma...
  45. ncbi request reprint Fas ligand and TNF-related apoptosis-inducing ligand induction on infiltrating lymphocytes in bladder carcinoma by bacillus Calmette-Guérin treatment
    Murat Mehmut
    Department of Urology, Juntendo University School of Medicine, Tokyo, Japan
    Urol Int 75:80-7. 2005
    ....
  46. ncbi request reprint Antiviral response by natural killer cells through TRAIL gene induction by IFN-alpha/beta
    K Sato
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Eur J Immunol 31:3138-46. 2001
    ..Thus, our study reveals a new molecular link between IFN-alpha/beta signaling and activation of NK cells in antiviral response of the host...
  47. doi request reprint Targeting spatiotemporal expression of CD137 on tumor-infiltrating cytotoxic T lymphocytes as a novel strategy for agonistic antibody therapy
    Shuichi Noji
    Department of Immunotherapeutics Medinet, The University of Tokyo Hospital, Tokyo, Japan
    J Immunother 35:460-72. 2012
    ..Tumor-specific CTL can guide agonistic anti-CD137 mAb to the tumor and in turn, become functionally augmented. Thus, CD137 mAb therapy may become feasible again in combination with tumor-specific CTL therapy...
  48. doi request reprint Correlation between loss of Bcl-XL expression and improved prognosis in advanced esophageal cancer treated by preoperative chemoradiotherapy
    M Okumura
    Department of Gastroenterological Surgery, Juntendo University School of Medicine, Tokyo, Japan
    Eur Surg Res 41:260-6. 2008
    ..These results suggested that CRT reduced Bcl-X(L) expression, and this decrease closely correlated with the prolonged survival of advanced esophageal cancer patients treated with preoperative CRT...
  49. ncbi request reprint Protective effect of NK1.1(+) T cells as well as NK cells against intraperitoneal tumors in mice
    T Kawamura
    Department of Immunology, Niigata University School of Medicine, Niigata, 951 8510, Japan
    Cell Immunol 193:219-25. 1999
    ..1(+) T cells to produce IFN-gamma and both NK cells and NK1.1(+) T cells are important in suppressing the growth of the intraperitoneal tumors...
  50. ncbi request reprint Antitumor effect of CD40 ligand: elicitation of local and systemic antitumor responses by IL-12 and B7
    A Nakajima
    Department of Immunology, Juntendo University, School of Medicine, Tokyo, Japan
    J Immunol 161:1901-7. 1998
    ..These results indicated a potent antitumor effect of CD40L that is mediated by potentiation of host Ag-presenting cell functions, and introduction of CD40L will be useful as a new strategy of immuno-gene therapy against tumors...
  51. ncbi request reprint Characterization of rat OX40 ligand by monoclonal antibody
    Y Satake
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Biochem Biophys Res Commun 270:1041-8. 2000
    ..These results indicated that OX40L is expressed on professional antigen-presenting cells (APC), and may be involved in humoral immune responses via T-B interaction and in cellular immune responses via T-DC interaction in the rat system...
  52. pmc Local effects of regulatory T cells in MUC1 transgenic mice potentiate growth of MUC1 expressing tumor cells in vivo
    Daisuke Sugiura
    Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    PLoS ONE 7:e44770. 2012
    ..Therefore, the enhanced growth of MUC1-expressing tumor cells in MUC1.Tg mice is likely due to the presence of MUC1-specific Treg cells...
  53. ncbi request reprint Effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the human NK-cell activity
    Kazuyoshi Takeda
    Department of Immunlogy, Juntendo University, School of Medicine, Tokyo 113 8421, Japan
    J Nutr 137:791S-3S. 2007
    ..These results suggest that daily intake of Lactobacillus casei strain Shirota provides a positive effect on NK-cell activity...
  54. doi request reprint CD1d-restricted natural killer T cells contribute to hepatic inflammation and fibrogenesis in mice
    Sachiko Ishikawa
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    J Hepatol 54:1195-204. 2011
    ....
  55. ncbi request reprint Expression of tumour necrosis factor (TNF) ligand superfamily co-stimulatory molecules CD30L, CD27L, OX40L, and 4-1BBL in murine hearts with acute myocarditis caused by Coxsackievirus B3
    Y Seko
    Department of Cardiovascular Medicine, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Pathol 195:593-603. 2001
    ....
  56. ncbi request reprint Impairment of bleomycin-induced lung fibrosis in CD28-deficient mice
    T Okazaki
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 167:1977-81. 2001
    ..Thus, manipulation of the CD28-mediated costimulation could be a potential therapeutic strategy for the prevention of lung fibrosis...
  57. ncbi request reprint Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages
    S Akashi
    Department of Immunology, Saga Medical School, Nabeshima, Japan
    J Immunol 164:3471-5. 2000
    ..Moreover, LPS-induced TNF-alpha production by peritoneal macrophages was inhibited by MTS510. Collectively, the TLR4-MD-2 complex is expressed on macrophages in vivo and senses and signals the presence of LPS...
  58. doi request reprint Phase I clinical trial of a peptide vaccine combined with tegafur-uracil plus leucovorin for treatment of advanced or recurrent colorectal cancer
    Norimasa Matsushita
    Department of Surgery, Institute of Gastroenterology, Tokyo Women s Medical University, Tokyo, Japan
    Oncol Rep 29:951-9. 2013
    ..Kaplan‑Meier analysis indicated that patients who had a strong CTL reaction had a tendency to have longer progression‑free survival and overall survival...
  59. ncbi request reprint Vaccination of mice with MUC1 cDNA suppresses the development of lung metastases
    Mika Kamata
    Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    Clin Exp Metastasis 19:689-96. 2002
    ..CD4+ cells and CD8+ cells apparently played some roles too...
  60. ncbi request reprint Organophosphorus pesticides markedly inhibit the activities of natural killer, cytotoxic T lymphocyte and lymphokine-activated killer: a proposed inhibiting mechanism via granzyme inhibition
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Toxicology 172:181-90. 2002
    ..We also found that DDVP significantly inhibited granzyme activity in a dose-dependent manner. These findings indicate that OPs significantly decrease NK, LAK and CTL activities in vitro via granzyme inhibition...
  61. ncbi request reprint Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor
    K Hoshino
    Department of Appropriate Technology Development, Research Institute, International Medical Center of Japan, Tokyo, Japan
    J Immunol 162:5041-4. 1999
    ..Th1 cell development was also impaired in IL-1Rrp-deficient mice. These data demonstrate that IL-1Rrp is a ligand-binding receptor that is essential for IL-18-mediated signaling events...
  62. pmc Signal transducer and activator of transcription 6 is essential in the induction of contact hypersensitivity
    H Yokozeki
    Department of Dermatology, School of Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Exp Med 191:995-1004. 2000
    ..Our data suggest that the STAT6 signal plays a critical role in the induction phase of CHS...
  63. pmc An allogeneic microenvironment influences the phenotype of intermediate T-cell receptor cells expanding in MRL-lpr/lpr mice
    A Tsukahara
    Department of Immunology, Niigata University School of Medicine, Japan
    Immunology 94:149-59. 1998
    ..Namely, DN CD4- CD8- cells as well as CD4+ cells which once acquired the mature phenotype, no longer switched their phenotype. These results suggest that the phenotype of TCRint cells is influenced by the surrounding microenvironment...
  64. ncbi request reprint Lymphotoxin lacks effects on 75-kDa receptors in cytotoxicity on U-937 cells
    S Iwamoto
    First Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan
    Biochem Biophys Res Commun 199:70-7. 1994
    ..These results indicate slight cytotoxicity of LT compared to TNF, due to inability of LT to signal through p75R on U-937 cells without significant loss of affinity to p75R...
  65. ncbi request reprint In vivo transfection of a cis element 'decoy' against signal transducers and activators of the transcription 6 (STAT6) binding site ameliorates the response of contact hypersensitivity
    K Sumi
    Department of Environmental Immunodermatology, Postgraduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Gene Ther 11:1763-71. 2004
    ..We herein report the first successful in vivo transfer of STAT6 decoy ODN to inhibit acute and chronic CHS, thus providing a new therapeutic strategy not only for the treatment of CHS but also for atopic dermatitis...
  66. ncbi request reprint In vivo transfection of a cis element 'decoy' against signal transducers and activators of transcription 6 (STAT6)-binding site ameliorates IgE-mediated late-phase reaction in an atopic dermatitis mouse model
    H Yokozeki
    Department of Dermatology and Immunodermatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Gene Ther 11:1753-62. 2004
    ..We herein report the first successful in vivo transfer of STAT6 decoy ODN to reduce the late-phase reaction, thereby providing a new therapeutic strategy for AD...
  67. pmc Interleukin-12 is involved in the enhancement of human natural killer cell activity by Lactobacillus casei Shirota
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    Clin Exp Immunol 146:109-15. 2006
    ..These results demonstrate that LcS can enhance NK cell activity in vivo and in vitro in humans, and IL-12 may be responsible for enhancement of NK cell activity triggered by LcS...
  68. doi request reprint CCL2-induced migration and SOCS3-mediated activation of macrophages are involved in cerulein-induced pancreatitis in mice
    Keita Saeki
    Department of Gastroenterology and Hepatology, Keio University School of Medicine, Tokyo, Japan
    Gastroenterology 142:1010-1020.e9. 2012
    ..We investigated the pathologic roles of innate immune cells, especially macrophages, in cerulein- and L-arginine-induced acute pancreatitis in mice...
  69. pmc Tumor necrosis factor receptor-associated factor (TRAF) 2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease
    Jiang Hu Piao
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo 113 8421, Japan
    J Biol Chem 286:17879-88. 2011
    ..Together, TRAF2 plays a crucial role in controlling homeostasis of the colon...
  70. doi request reprint Quality of life and disease-related symptoms in previously treated Japanese patients with non-small-cell lung cancer: results of a randomized phase III study (V-15-32) of gefitinib versus docetaxel
    I Sekine
    Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan
    Ann Oncol 20:1483-8. 2009
    ..This report describes quality of life (QoL) findings of a randomized study comparing gefitinib with docetaxel in patients with advanced/metastatic pretreated non-small-cell lung cancer...
  71. ncbi request reprint Abundance of unconventional CD8(+) natural killer T cells in the large intestine
    M Bannai
    Department of Immunology, Niigata University School of Medicine, Niigata, Japan
    Eur J Immunol 31:3361-9. 2001
    ..These findings suggest that the large intestine is a site in which unconventional NKT cells carrying the CD8(+) phenotype (or DN CD4(-)8(-)) are abundant and that these cells are independent of MHC and MHC-like antigens...
  72. pmc ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
    K Tobiume
    Laboratory of Cell Signaling, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    EMBO Rep 2:222-8. 2001
    ..TNF- but not Fas-induced apoptosis requires ROS-dependent activation of ASK1-JNK/p38 pathways. Thus, ASK1 is selectively required for TNF- and oxidative stress-induced sustained activations of JNK/p38 and apoptosis...
  73. ncbi request reprint T-cell-immunity-based inhibitory effects of orally administered herbal medicine juzen-taiho-to on the growth of primarily developed melanocytic tumors in RET-transgenic mice
    Y Dai
    Department of Immunology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Invest Dermatol 117:694-701. 2001
    ..These results suggest that juzen-taiho-to suppresses once-developed primary melanocytic tumors through potentiation of T-cell-mediated antitumor cytotoxic immunity in vivo...
  74. ncbi request reprint Detection of telomerase activity in biopsy specimens for diagnosis of biliary tract cancers
    T Itoi
    Fourth Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    Gastrointest Endosc 52:380-6. 2000
    ..We determined telomerase activity in biopsy specimens obtained from biliary tract cancers to evaluate the clinical application of telomerase activity detection in combination with p53 immunostaining and routine histologic examination...
  75. ncbi request reprint Normal development of the gut-associated lymphoid tissue except Peyer's patch in MyD88-deficient mice
    R Iiyama
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Scand J Immunol 58:620-7. 2003
    ..These results suggest that the TLRs/MyD88 pathway might be involved in the development of PPs only at early postnatal stage, and TLRs/MyD88-independent signalling is critically involved in the development of GALT in adult mice...
  76. pmc Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
    M Saitoh
    Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170, Japan
    EMBO J 17:2596-606. 1998
    ..The evidence that Trx is a negative regulator of ASK1 suggests possible mechanisms for redox regulation of the apoptosis signal transduction pathway as well as the effects of antioxidants against cytokine- and stress-induced apoptosis...
  77. ncbi request reprint Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice
    H Takagi
    Dept of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Scand J Gastroenterol 38:837-44. 2003
    ..The present study was conducted to determine the distinct roles of IL-12 and IL-18 in the development of dextran sulphate sodium (DSS) colitis in mice...
  78. ncbi request reprint Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease
    T Kanai
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    Gastroenterology 121:875-88. 2001
    ..Here we assess the role of macrophages and of IL-18 in the murine model of intestinal inflammation that mimics the immunologic characteristics of human CD...
  79. ncbi request reprint ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction
    Y Mochida
    Laboratory of Cell Signaling, Department of Hard Tissue Engineering, Division of Bio Matrix, Tokyo, Japan
    J Biol Chem 275:32747-52. 2000
    ..These results provide a new insight in the mode of action of MAPKKK family members; two distinct MAPKKKs in the same MAP kinase cascades directly interact and exert opposite effects in another signaling pathway, NF-kappaB...
  80. ncbi request reprint Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase
    Y Sawada
    Laboratory of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8549, Japan
    J Cell Sci 114:1221-7. 2001
    ..Thus, Rap1 plays a unique role in force-initiated signal transduction...
  81. ncbi request reprint Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation
    S Takeuchi
    Department of Biochemistry, Kobe University, School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Genes Cells 5:71-8. 2000
    ..To elucidate the function of mRor2, we generated mice with a mutated mRor2 locus...
  82. ncbi request reprint Recombinant murine interleukin-12 facilitates induction of cardiac myosin-specific type 1 helper T cells in rats
    Y Okura
    Department of Immunology, Niigata University School of Medicine, Japan
    Circ Res 82:1035-42. 1998
    ..IL-12 and IL-2 potentiate the expansion of cardiac myosin-specific Th1 cells and play an important role in the development of autoimmune myocardial injury...
  83. ncbi request reprint ASK1 is essential for JNK/SAPK activation by TRAF2
    H Nishitoh
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Mol Cell 2:389-95. 1998
    ..In untransfected mammalian cells, ASK1 rapidly associates with TRAF2 in a TNF-dependent manner. Thus, ASK1 is a mediator of TRAF2-induced JNK activation...
  84. ncbi request reprint Pro-apoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons
    W Araki
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    J Neurochem 79:1161-8. 2001
    ..These data collectively suggest that the pro-apoptotic effect of PS2 is mediated by down-regulation of Bcl-2. PS2 mutations may increase the susceptibility of neurons to apoptotic stimuli by perturbing the regulation of cell death...
  85. ncbi request reprint Successful conversion from prednisolone to methylprednisolone for immunosuppression: a case report
    H Sekido
    Department of Surgery II, Yokohama City University, School of Medicine, Yokohama, Japan
    Transplant Proc 35:223-4. 2003
  86. doi request reprint Co-inhibitory roles for glucocorticoid-induced TNF receptor in CD1d-dependent natural killer T cells
    Shuming Chen
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Eur J Immunol 38:2229-40. 2008
    ..Furthermore, the in vivo administration of alpha-GalCer suppressed tumor metastasis more efficiently in GITR-deficient mice than in wild-type mice. Collectively, GITR plays a co-inhibitory role in Ag-induced iNKT cell activation...
  87. ncbi request reprint NKT cells - conductors of tumor immunity?
    Mark J Smyth
    Cancer Immunology, Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
    Curr Opin Immunol 14:165-71. 2002
    ....
  88. ncbi request reprint A role for IFN-gamma in primary and secondary immunity generated by NK cell-sensitive tumor-expressing CD80 in vivo
    Janice M Kelly
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
    J Immunol 168:4472-9. 2002
    ..Our findings demonstrate a key role for IFN-gamma in innate and adaptive immunity triggered by CD80 expression on tumor cells...
  89. ncbi request reprint Critical contribution of CD80 and CD86 to induction of anterior chamber-associated immune deviation
    Rintaro Tsukahara
    Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Int Immunol 17:523-30. 2005
    ..The present results indicated that CD80 and CD86 play a critical role in induction of ACAID, possibly by co-stimulating expansion and IL-10 production of regulatory T cells in response to TGF-beta-conditioned APC...
  90. ncbi request reprint Interleukin-12 administration is more effective for preventing metastasis than for inhibiting primary established tumors in a murine model of spontaneous hepatic metastasis
    Terutada Kobayashi
    Department of Surgery, Postgraduate School of Medicine, Tohoku University, Sendai, Japan
    Surg Today 32:236-42. 2002
    ..The effect of interleukin-12 (IL-12) on tumor growth at the primary site and its therapeutic efficacy against metastasis were examined using a model of spontaneous hepatic metastasis...
  91. ncbi request reprint Induction of tumor-specific T cell memory by NK cell-mediated tumor rejection
    Janice M Kelly
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria, Australia
    Nat Immunol 3:83-90. 2002
    ..Thus CD27-CD70 interactions provide a key link between innate NK cell responses and adaptive T cell immunity...
  92. ncbi request reprint IFN-gamma-mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, alpha-galactosylceramide
    Yoshihiro Hayakawa
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan
    Blood 100:1728-33. 2002
    ..These results suggest that the IFN-gamma-mediated inhibition of tumor angiogenesis is critically involved in the effector mechanisms of antitumor effects evoked by alpha-GalCer...
  93. ncbi request reprint Activation of NK cell cytotoxicity
    Mark J Smyth
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, VIC 8006, Australia
    Mol Immunol 42:501-10. 2005
    ..This review will discuss the functional importance of NK cell cytotoxicity and the receptor/ligand interactions that control these processes...
  94. ncbi request reprint New aspects of natural-killer-cell surveillance and therapy of cancer
    Mark J Smyth
    Cancer Immunology Laboratory, Trescowthick Research Laboratories, Research Division, Peter MacCallum Cancer Institute, Locked Bag 1, A Beckett Street, Melbourne 8006, Australia
    Nat Rev Cancer 2:850-61. 2002
  95. ncbi request reprint Nature's TRAIL--on a path to cancer immunotherapy
    Mark J Smyth
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria 3002, Australia
    Immunity 18:1-6. 2003
    ....
  96. pmc Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice
    Tomohiro Yoshimoto
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    J Exp Med 197:997-1005. 2003
    ..These findings indicate that NKT cells might be the major source of IL-4 in response to IL-18 administration and that conventional CD4+ T cells demonstrate their helper function in the presence of NKT cells...
  97. ncbi request reprint Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected mice
    Keishi Adachi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Japan
    Int Immunol 16:787-98. 2004
    ..berghei-induced liver injury. Our studies may have general implications for tissue injuries that are caused by 'bystander killing' or other poorly defined cell-mediated killing mechanisms...
  98. ncbi request reprint IL-21 enhances tumor-specific CTL induction by anti-DR5 antibody therapy
    Mark J Smyth
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Center, A Beckett Street, Victoria 8006, Australia
    J Immunol 176:6347-55. 2006
    ..These results indicate that a rational combination of Ab-based therapy that causes tumor cell apoptosis and a cytokine that promotes T cell memory is a useful new strategy for cancer immunotherapy...
  99. ncbi request reprint Sequential production of interferon-gamma by NK1.1(+) T cells and natural killer cells is essential for the antimetastatic effect of alpha-galactosylceramide
    Mark J Smyth
    Cancer Immunology, Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
    Blood 99:1259-66. 2002
    ....
  100. pmc Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibody
    Anil Shanker
    Laboratory of Experimental Immunology, Cancer and Inflammation Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Natl Cancer Inst 100:649-62. 2008
    ..All statistical tests were two-sided...