Fumiyuki Takahashi

Summary

Affiliation: Juntendo University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Endostatin gene transfer in murine lung carcinoma cells induces vascular endothelial growth factor secretion resulting in up-regulation of in vivo tumorigenecity
    Ri Cui
    Department of Respiratory Medicine, Juntendo University, School of Medicine, 2 1 1 Hongo Bunkyo ku, Tokyo 113 8421, Japan
    Cancer Lett 232:262-71. 2006
  2. doi request reprint Isolated congenital spleen agenesis: a rare cause of chronic thromboembolic pulmonary hypertension in an adult
    Fumiyuki Takahashi
    Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Respirology 13:913-5. 2008
  3. ncbi request reprint Osteopontin is strongly expressed by alveolar macrophages in the lungs of acute respiratory distress syndrome
    Fumiyuki Takahashi
    Department of Respiratory Medicine, Juntendo University School of Medicine, Hongo, Bunkyo ku, Tokyo, Japan
    Lung 182:173-85. 2004
  4. ncbi request reprint Adenocarcinoma of the thymus: mucinous subtype
    Fumiyuki Takahashi
    Department of Respiratory Medicine, Juntendo University, School of Medicine, Tokyo 113 8421, Japan
    Hum Pathol 36:219-23. 2005
  5. ncbi request reprint Pulmonary sarcoidosis and antiphospholipid syndrome
    Fumiyuki Takahashi
    Department of Respiratory Medicine, Juntendo University, School of Medicine, Hongo, Tokyo, Japan
    Respirology 11:506-8. 2006
  6. ncbi request reprint Abrogation of the interaction between osteopontin and alphavbeta3 integrin reduces tumor growth of human lung cancer cells in mice
    Ri Cui
    Department of Respiratory Medicine, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Lung Cancer 57:302-10. 2007
  7. ncbi request reprint Osteopontin modulates malignant pleural mesothelioma cell functions in vitro
    Rina Ohashi
    Department of Respiratory Medicine, Juntendo University, School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Anticancer Res 29:2205-14. 2009
  8. doi request reprint Osteopontin is involved in the formation of malignant pleural effusion in lung cancer
    Ri Cui
    Department of Respiratory Medicine, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Lung Cancer 63:368-74. 2009
  9. ncbi request reprint Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell
    Rina Ohashi
    Department of Respiratory Medicine, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Cancer Lett 252:225-34. 2007
  10. ncbi request reprint Serum tenascin-C as a potential predictive marker of angiogenesis in non-small cell lung cancer
    Toshiji Ishiwata
    Department of Respiratory Medicine, Juntendo University, School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Anticancer Res 25:489-95. 2005

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Endostatin gene transfer in murine lung carcinoma cells induces vascular endothelial growth factor secretion resulting in up-regulation of in vivo tumorigenecity
    Ri Cui
    Department of Respiratory Medicine, Juntendo University, School of Medicine, 2 1 1 Hongo Bunkyo ku, Tokyo 113 8421, Japan
    Cancer Lett 232:262-71. 2006
    ..More attention should be paid for ED gene therapy into lung cancer cells since it may influence other proteins secretion, which upregulates angiogenesis...
  2. doi request reprint Isolated congenital spleen agenesis: a rare cause of chronic thromboembolic pulmonary hypertension in an adult
    Fumiyuki Takahashi
    Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Respirology 13:913-5. 2008
    ..Although congenital spleen agenesis is a rare condition, this case report suggests that this possibility should be considered when a diagnosis of CTPH and thrombocytosis is made...
  3. ncbi request reprint Osteopontin is strongly expressed by alveolar macrophages in the lungs of acute respiratory distress syndrome
    Fumiyuki Takahashi
    Department of Respiratory Medicine, Juntendo University School of Medicine, Hongo, Bunkyo ku, Tokyo, Japan
    Lung 182:173-85. 2004
    ..It is possible that OPN is partially involved in playing a protective role against excessive production of NO in ARDS...
  4. ncbi request reprint Adenocarcinoma of the thymus: mucinous subtype
    Fumiyuki Takahashi
    Department of Respiratory Medicine, Juntendo University, School of Medicine, Tokyo 113 8421, Japan
    Hum Pathol 36:219-23. 2005
    ..Collectively, the diagnosis of the tumor was primary mucinous adenocarcinoma of the thymus. We propose that the mucinous subtype should be recognized as one of the histopathological entities of thymic adenocarcinoma...
  5. ncbi request reprint Pulmonary sarcoidosis and antiphospholipid syndrome
    Fumiyuki Takahashi
    Department of Respiratory Medicine, Juntendo University, School of Medicine, Hongo, Tokyo, Japan
    Respirology 11:506-8. 2006
    ..This is the first APS case where pulmonary involvement with sarcoidosis has been confirmed through lung biopsy. Our case report suggests that APS should be recognized as an accompanying disorder of sarcoidosis...
  6. ncbi request reprint Abrogation of the interaction between osteopontin and alphavbeta3 integrin reduces tumor growth of human lung cancer cells in mice
    Ri Cui
    Department of Respiratory Medicine, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Lung Cancer 57:302-10. 2007
    ..Targeting the interaction between OPN and alphavbeta3 integrin could be effective for future development of anti-angiogenic therapeutic agents for patients with lung cancer...
  7. ncbi request reprint Osteopontin modulates malignant pleural mesothelioma cell functions in vitro
    Rina Ohashi
    Department of Respiratory Medicine, Juntendo University, School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Anticancer Res 29:2205-14. 2009
    ..Although serum osteopontin (OPN) concentration is elevated in patients with malignant pleural mesothelioma (MPM), the role of OPN in the pathogenesis and development of MPM remains unknown...
  8. doi request reprint Osteopontin is involved in the formation of malignant pleural effusion in lung cancer
    Ri Cui
    Department of Respiratory Medicine, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Lung Cancer 63:368-74. 2009
    ..OPN could be an effective target molecule for reducing MPE in lung cancer patients...
  9. ncbi request reprint Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell
    Rina Ohashi
    Department of Respiratory Medicine, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Cancer Lett 252:225-34. 2007
    ..These results suggest that the interaction between CD44s and HA play a pivotal role in acquired resistance to CDDP in NSCLC and MRP2 could be involved in this potential mechanism...
  10. ncbi request reprint Serum tenascin-C as a potential predictive marker of angiogenesis in non-small cell lung cancer
    Toshiji Ishiwata
    Department of Respiratory Medicine, Juntendo University, School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Anticancer Res 25:489-95. 2005
    ..Tenascin (Tn)-C is an extracellular matrix protein that is involved in tissue interactions during fetal development and oncogenesis. However, the role of serum Tn-C in non-small cell lung cancer (NSCLC) has not been clarified...
  11. ncbi request reprint Osteopontin overproduced by tumor cells acts as a potent angiogenic factor contributing to tumor growth
    Michihiro Hirama
    Department of Respiratory Medicine, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Cancer Lett 198:107-17. 2003
    ..Conclusively, these results strongly imply that OPN plays an important role in tumor growth through the enhancement of angiogenesis in vivo...
  12. ncbi request reprint Signal transduction mediated by endostatin directly modulates cellular function of lung cancer cells in vitro
    Ri Cui
    Department of Respiratory Medicine and Research Institute for Diseases of Old Age, Juntendo University, School of Medicine, Tokyo, Japan
    Cancer Sci 98:830-7. 2007
    ..Taken together, these results suggest that the interaction between ED and alpha5 integrin may play an important role in lung cancer cell function...
  13. doi request reprint Osteopontin expression in pulmonary tumor thrombotic microangiopathy caused by gastric carcinoma
    Fumiyuki Takahashi
    Department of Respiratory Medicine, Juntendo University, School of Medicine, Tokyo, Japan
    Pathol Int 59:752-6. 2009
    ..To the best of the authors' knowledge this is the first report to demonstrate the possible involvement of OPN in PTTM. It is postulated that OPN is one of the candidate molecules for the development of PTTM...
  14. ncbi request reprint Vinorelbine is effective for the malignant pleural effusion associated with lung cancer in mice
    Ri Cui
    Department of Respiratory Medicine, Juntendo University, School of Medicine, Bunkyo ku, Tokyo, Japan
    Anticancer Res 28:1633-9. 2008
    ..These results suggest that VNR may be effective for the treatment of MPE associated with lung cancer not only by its cytotoxic effect but also through down-regulation of VEGF expression in lung cancer cells...
  15. doi request reprint Acquired resistance of non-small cell lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors
    Fariz Nurwidya
    Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, 2 1 1 Hongo, Bunkyo, Tokyo 113 8421, Japan Electronic address
    Respir Investig 52:82-91. 2014
    ..This review will discuss the biology of receptor tyrosine kinase inhibition and focus on the molecular mechanisms of acquired resistance to tyrosine kinase inhibitors of EGFR-mutant NSCLC. ..
  16. doi request reprint Successful resection of dermatomyositis associated with thymic carcinoma: report of a case
    Fumiyuki Takahashi
    Department of Respiratory Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Surg Today 38:245-8. 2008
    ..We propose that thymic carcinoma should be added to the list of malignancies that can complicate DM as a paraneoplastic disease...
  17. ncbi request reprint Role of serum vascular endothelial growth factor in the prediction of angiogenesis and prognosis for non-small cell lung cancer
    Yuri Shimanuki
    Department of Respiratory Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Lung 183:29-42. 2005
    ..Conclusively, preoperative concentration of serum VEGF may be the most valuable marker in the prediction of intratumoral angiogenesis and prognosis of patients with NSCLC...
  18. pmc Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor
    Akiko Murakami
    Department of Respiratory Medicine, Juntendo University, Graduate School of Medicine, Tokyo, Japan Research Institute for Diseases of Old Ages, Juntendo University, Graduate School of Medicine, Tokyo, Japan
    PLoS ONE 9:e86459. 2014
    ..Targeting the IGF1R pathway may be a promising strategy for overcoming gefitinib resistance in EGFR mutation-positive NSCLC induced by lung CSCs and microenvironment factors such as tumor hypoxia. ..
  19. ncbi request reprint Restoration of CD44S in non-small cell lung cancer cells enhanced their susceptibility to the macrophage cytotoxicity
    Kazuhisa Takahashi
    Department of Respiratory Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Lung Cancer 41:145-53. 2003
    ..These findings suggest that CD44S down-regulation in NSCLC cells may confer a protective advantage of allowing escape from tumoricidal effector cells including activated macrophages of the host...
  20. doi request reprint Sex hormones alter Th1 responses and enhance granuloma formation in the lung
    Ken Tajima
    Department of Respiratory Medicine, School of Medicine, Juntendo University, Tokyo, Japan tajiken juntendo ac jp
    Respiration 81:491-8. 2011
    ..Objectives: The purpose of this study was to assess whether sex hormones are involved in granulomatous inflammation and to evaluate how sex hormones modulate this response in the lung...
  21. ncbi request reprint Genistein attenuates hypoxic pulmonary hypertension via enhanced nitric oxide signaling and the erythropoietin system
    Sachiko Kuriyama
    Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 306:L996-L1005. 2014
    ..We conclude that Gen may be effective for the prevention of hypoxic PH through the improvement of PI3K/Akt-dependent, NO-mediated signaling in association with enhancement of the EPO/EPOR system. ..
  22. doi request reprint Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-type epidermal growth factor receptors
    Kunihiko Minakata
    Department of Respiratory Medicine, Juntendo University, Tokyo, Japan
    Cancer Sci 103:1946-54. 2012
    ..The presence of wild-type and mutant EGFR along with tumor hypoxia are important factors that should be considered when treating NSCLC patients with gefitinib...
  23. doi request reprint Role of multidrug resistance-associated protein 1 in the pathogenesis of allergic airway inflammation
    Masakata Yoshioka
    Dept of Respiratory Medicine, Juntendo Univ School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Am J Physiol Lung Cell Mol Physiol 296:L30-6. 2009
    ..Our results indicate that MRP1 plays an important role in the development of allergic airway inflammation through regulation of IgE-mediated CysLT export from mast cells...
  24. ncbi request reprint Tocilizumab, a proposed therapy for the cachexia of interleukin6-expressing lung cancer
    Katsutoshi Ando
    Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Bunkyo ku, Tokyo, Japan
    PLoS ONE 9:e102436. 2014
    ....
  25. doi request reprint Lung cancer stem cells: tumor biology and clinical implications
    Fariz Nurwidya
    Department of Respiratory Medicine, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Asia Pac J Clin Oncol 8:217-22. 2012
    ..As lung cancer is the leading cause of cancer-related deaths worldwide, we focus on the properties and clinical implications of lung CSC...
  26. pmc Hochuekkito (TJ-41), a Kampo Formula, Ameliorates Cachexia Induced by Colon 26 Adenocarcinoma in Mice
    Suzu Yae
    Department of Respiratory Medicine, School of Medicine, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan Research Institute for Diseases of Old Age, School of Medicine, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Evid Based Complement Alternat Med 2012:976926. 2012
    ..Therefore, hochuekkito may be a promising anticachectic agent for the treatment of patients with cancer...
  27. ncbi request reprint Pancoast's syndrome in a patient with B-cell lymphoma diagnosed and confirmed with immunoglobulin gene rearrangement
    Fumiyuki Takahashi
    Department of Respiratory Medicine, Juntendo University, School of Medicine, Tokyo, Japan
    Respirology 9:137-40. 2004
    ..This is the first reported case of Pancoast's syndrome caused by B-cell lymphoma, which was accurately diagnosed by analysis of gene rearrangement...
  28. ncbi request reprint Chronic intermittent hypoxia/reoxygenation facilitate amyloid-β generation in mice
    Satomi Shiota
    Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
    J Alzheimers Dis 37:325-33. 2013
    ..CIH directly and selectively increased levels of Aβ42 in the AD model. Our results suggest that OSA would aggravate AD. Early detection and intervention of OSA in AD may help to alleviate the progression of the disease. ..
  29. pmc Molecular mechanisms contributing to resistance to tyrosine kinase-targeted therapy for non-small cell lung cancer
    Fariz Nurwidya
    Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Cancer Biol Med 9:18-22. 2012
    ..An in-depth understanding of these targeted-therapy resistance may help us explore new strategies for overcoming or reversing the resistance to these inhibitors for the future of NSCLC treatment...
  30. pmc Epithelial mesenchymal transition in drug resistance and metastasis of lung cancer
    Fariz Nurwidya
    Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Cancer Res Treat 44:151-6. 2012
    ..This review describes recent evidence of EMT involvement in drug resistance and metastasis of cancers, with an emphasis on lung cancer...
  31. pmc From tumor hypoxia to cancer progression: the implications of hypoxia-inducible factor-1 expression in cancers
    Fariz Nurwidya
    Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Anat Cell Biol 45:73-8. 2012
    ..Some novel agents have been shown to have HIF-1 inhibition activity through a variety of molecular mechanisms and have provided promising results in the preclinical setting...
  32. ncbi request reprint Ultrasonographic evaluation of the diaphragm in patients with amyotrophic lateral sclerosis
    Yasuko Yoshioka
    Department of Respiratory Medicine, Juntendo University, School of Medicine, Tokyo, Japan
    Respirology 12:304-7. 2007
    ..Ultrasonography may be useful for the diagnosis and follow up of diaphragmatic involvement with amyotrophic lateral sclerosis and other motor-neuron diseases...
  33. pmc Hydration with magnesium and mannitol without furosemide prevents the nephrotoxicity induced by cisplatin and pemetrexed in patients with advanced non-small cell lung cancer
    Keiko Muraki
    Department of Respiratory Medicine, Juntendo University, School of Medicine, Japan
    J Thorac Dis 4:562-8. 2012
    ....
  34. ncbi request reprint Osteopontin induces angiogenesis of murine neuroblastoma cells in mice
    Fumiyuki Takahashi
    Pharmacology Division, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Int J Cancer 98:707-12. 2002
    ..The OPN-transfected cells significantly induced neovascularization in comparison to the control cells in mice. Conclusively, these results provide direct evidence of OPN involvement in the role of tumor angiogenesis...
  35. ncbi request reprint Enhanced antitumor activities of TZT-1027 against TNF-alpha or IL-6 secreting Lewis lung carcinoma in vivo
    Tsugitaka Natsume
    Pharmacological Research Department, Teikoku Hormone Mfg, Co Ltd, Kawasaki shi, Kanagawa, Japan
    Cancer Chemother Pharmacol 49:35-47. 2002
    ....