Affiliation: Juntendo University School of Medicine
Fujimaki M, Saiki S, Li Y, Kaga N, Taka H, Hatano T, et al
. Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease. Neurology. 2018;90:e404-e411 pubmed publisher
..This study provides Class III evidence that decreased serum levels of caffeine and its metabolites identify patients with PD. ..
Ueno S, Saiki S, Fujimaki M, Takeshige Amano H, Hatano T, Oyama G, et al
. Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson's Disease. Cells. 2018;8: pubmed publisher
..Because an upregulation of LCACs implies improvement of mitochondrial β-oxidation, zonisamide might be beneficial for mitochondrial β-oxidation, which is suppressed in PD. ..
Ishikawa K, Saiki S, Furuya N, Imamichi Y, Tsuboi Y, Hattori N. p150glued deficiency impairs effective fusion between autophagosomes and lysosomes due to their redistribution to the cell periphery. Neurosci Lett. 2019;690:181-187 pubmed publisher
..Our data demonstrate that functional loss of p150glued may cause autophagic insufficiency, which may be associated with the pathogenesis of p150glued-associated disorders. ..
Saiki S, Ueno Y, Moritani T, Sato T, Sekine T, Kawajiri S, et al
. Extensive hemispheric lesions with radiological evidence of blood-brain barrier integrity in a patient with neuromyelitis optica. J Neurol Sci. 2009;284:217-9 pubmed publisher
..The findings suggest possible involvement of deficient water elimination associated with seropositivity to NMO-IgG in the induction of vasogenic edema even in the presence of intact and functional BBB. ..
Fujimaki M, Saiki S, Sasazawa Y, Ishikawa K, Imamichi Y, Sumiyoshi K, et al
. Immunocytochemical Monitoring of PINK1/Parkin-Mediated Mitophagy in Cultured Cells. Methods Mol Biol. 2018;1759:19-27 pubmed publisher
..In this chapter, we summarized immunocytochemical methods to monitor the PINK1/parkin-mediated mitophagy using cultured cells. ..