Research Topics
| Michiro OtakaSummaryAffiliation: Juntendo University School of Medicine Country: Japan Publications
| Collaborators
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Detail Information
Publications
Overexpression of a 60-kDa heat shock protein enhances cytoprotective function of small intestinal epithelial cellsMakiko Takada
Department of Gastroenterology, Juntendo University School of Medicine, Japan
Life Sci 86:499-504. 2010..In this study, we examined the effect of HSP60 or HSP70 overexpression on hydrogen peroxide-induced (H2O2) or indomethacin-induced cell damage in the small intestinal epithelial cells...- Expression and function of stress (heat shock) proteins in gastrointestinal tractMichiro Otaka
Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
Int J Hyperthermia 25:634-40. 2009..In addition, these findings in post-genomic level may provide new strategies for the therapy of gastrointestinal disorders... 
Acute variceal bleeding in a patient with idiopathic myelofibrosis successfully treated with endoscopic variceal band ligation and chemotherapy: a case reportKumiko Tamaki
Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
J Med Case Reports 4:25. 2010..Gastrointestinal hemorrhages, which are due mostly to the rupture of the esophageal varices, have been sporadically reported to be an infrequent complication of idiopathic myelofibrosis...- Target molecules of molecular chaperone (HSP70 family) in injured gastric mucosa in vivoMichiro Otaka
Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
Life Sci 84:664-7. 2009..In the present study, gastric mucosal proteins that specifically bind to the HSP70 family (HSC70) were analyzed using HSC70-affinity chromatography... - Colonic mucosal lesions associated with low-dose aspirin: a case control studyTomoyoshi Shibuya
Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
Scand J Gastroenterol 46:810-7. 2011..Recently, there has been a substantial increase in prescriptions for LDA. We analyzed the risk of colonic mucosal lesions associated with the long-term use of LDA... 
Attenuation of gastric mucosal inflammation induced by aspirin through inhibition of selective type III phospshodiesterase in ratsMasaru Odashima
Department of Gastroenterology, Akita University of Medicine, 1 1 1, Hondo, Akita City, 010 8543, Akita, Japan
Dig Dis Sci 52:1355-9. 2007..Cilostazol may be useful for preventing gastric mucosal lesions induced by aspirin...- Clinicopathological characteristics of colorectal cancer less than 10 mm in diameter and invading submucosa and belowKazuko Beppu
Department of Gastroenterology, School of Medicine, Juntendo University, Tokyo, Japan
J Gastroenterol Hepatol 25:S57-61. 2010..This study examines the clinicopathological characteristics of colorectal cancers less than 10 mm in diameter and invading submucosal layer (SM)3 and below, which require surgery and must never be treated by endoscopic mucosal resection... - Relationship between endoscopic findings and clinical severity in ischemic colitisKazuko Beppu
Department of Gastroenterology, Juntendo University, School of Medicine, Japan
Intern Med 50:2263-7. 2011..The incidence of ischemic colitis (IC) in Japan has been increasing due to the westernization of diet and the aging population. The aim of this study was to evaluate the relationship between endoscopic findings and clinical severity in IC... - Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in ratsShigeto Koizumi
Department of Gastroenterology, Akita University School of Medicine, Akita, Japan
J Gastroenterol 44:419-25. 2009.... - Gastrointestinal tuberculosis as a cause of massive bleedingKazuko Beppu
Department of Gastroenterology, Juntendo University, School of Medicine, Tokyo, Japan
Med Sci Monit 15:CS151-154. 2009..Although minor bleeding is fairly common among cases of gastrointestinal tuberculosis, massive hemorrhage necessitating blood transfusion is rare... - Specific induction of a 72-kDa heat shock protein protects esophageal mucosa from reflux esophagitisYuko Izumi
Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
Life Sci 84:517-22. 2009..The aim of this study is to investigate the expression and cytoprotective function of a 72-kDa heat shock protein (HSP72) using a reflux esophagitis model in rats... - A selective adenosine A2A receptor agonist, ATL-146e, prevents concanavalin A-induced acute liver injury in miceMasaru Odashima
Department of Gastroenterology, Akita University School of Medicine, Akita, Japan
Biochem Biophys Res Commun 347:949-54. 2006..The aim of the present study was to determine whether ATL-146e could ameliorate Con A-induced hepatic injury, reduction of pro-inflammatory cytokine production... - Zinc L-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-kappaB activationMasaru Odashima
Department of Gastroenterology, Akita University School of Medicine, 1 1 1, Hondo, Akita City, Akita 010 8543, Japan
Life Sci 79:2245-50. 2006.... - Establishment of a reflux esophago-laryngitis model in ratsDaisuke Asaoka
Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1, Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
Dig Dis Sci 56:1299-308. 2011..To investigate the pathophysiology of reflux laryngitis, an experimental model is required... - Colonic mucosal lesions associated with long-term or short-term administration of nonsteroidal anti-inflammatory drugsTomoyoshi Shibuya
Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
Colorectal Dis 12:1113-21. 2010..We assessed the risk of developing colonic mucosal lesions according to the duration of exposure to NSAIDs: short-term and/or long-term use... - Characteristic pathological findings and effects of ecabet sodium in rat reflux esophagitisDaisuke Asaoka
Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1, Hongo, Bunkyo ku, Tokyo 113 8421, Japan
World J Gastroenterol 15:3480-5. 2009..To explore the pathological findings in the entire esophagus in rats with reflux esophagitis, and the effects of ecabet sodium (ES)... - Successful treatment of refractory duodenal Crohn's disease with infliximabMasaru Odashima
Department of Gastroenterology, Akita University of Medicine, 1-1-1, Hondo, Akita City, Akita 010-8543, Japan
Dig Dis Sci 52:31-2. 2007 - Observational comparative trial of the efficacy of proton pump inhibitors versus histamine-2 receptor antagonists for uninvestigated dyspepsiaAkihito Nagahara
Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
J Gastroenterol Hepatol 25:S122-8. 2010..It is still controversial which drugs, proton pump inhibitors (PPI) or histamine-2 receptor antagonists (H2RA), are more effective for dyspepsia in the Japanese population... - Hamartomatous inverted polyp successfully treated by endoscopic submucosal dissectionMasaru Odashima
Department of Gastroenterology, Akita University School of Medicine, Akita, Japan
Intern Med 47:259-62. 2008..ESD method may be indicated for SMT-type hamartomatous inverted polyps... - Correlation of heat shock protein expression to gender difference in development of stress-induced gastric mucosal injury in ratsTaiji Takahashi
Department of Gastroenterology, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
J Clin Biochem Nutr 47:64-73. 2010..Our results suggested that estrogen might play an important role in gastric mucosal protection with the induction of gastric mucosal HSPs... - Comparison of several activity indices for the evaluation of endoscopic activity in UC: inter- and intraobserver consistencyTaro Osada
Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
Inflamm Bowel Dis 16:192-7. 2010..This study evaluated inter- and intraobserver agreement in the assessment of ulcerative colitis (UC) activity using 4 established indices and a newly designed Modified 6-point Activity Index... - Endoscopic submucosal dissection of large colorectal tumors by using a novel spring-action S-O clip for traction (with video)Naoto Sakamoto
Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
Gastrointest Endosc 69:1370-4. 2009..In this report, we describe a novel spring-action version of the S-O clip (spring S-O clip) that improves the facility of clip use during ESD of colorectal tumors... - Mechanical strain stress suppresses expression of HSP70 and wound restoration in gastric mucosal cellsMasaru Odashima
Department of Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
Dig Dis Sci 52:3087-91. 2007..On the other hand, the wound restoration of 7018-RGM-1 cells was not affected by mechanical stretch. These results suggest that HSP70 plays an important role in gastric wound healing under physical stress... - The relationship between physical activity level and completion rate of small bowel examination in patients undergoing capsule endoscopyTomoyoshi Shibuya
Department of Gastroenterology, Juntendo University School of Medicine, Japan
Intern Med 51:997-1001. 2012..Attempts to improve the completion rate (CR) as defined by reaching the cecum have been unsuccessful. This study was to investigate the relationship between patients' physical activity and CR... - Traditional Herbal Medicine, Rikkunshito, Induces HSP60 and Enhances Cytoprotection of Small Intestinal Mucosal Cells as a Nontoxic Chaperone InducerKumiko Tamaki
Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
Evid Based Complement Alternat Med 2012:278958. 2012..Our results suggested that HSP60 induced by TJ-43 might play an important role in protecting small intestinal epithelial cells from apoptosis and necrosis in vitro... - Evidence for enhanced cytoprotective function of HSP90-overexpressing small intestinal epithelial cellsKumiko Tamaki
Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
Dig Dis Sci 56:1954-61. 2011.... - Large Brunner's gland hyperplasia treated with modified endoscopic submucosal dissectionReina Ohba
Department of Gastroenterology, Akita University School of Medicine, 1-1-1, Hondo, Akita City, Akita 010-8543, Japan
Dig Dis Sci 52:170-2. 2007 - Double-balloon endoscopy for treatment of long-term abdominal discomfort due to small bowel penetration by an eel boneTomoyoshi Shibuya
Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
Med Sci Monit 14:CS107-9. 2008..Penetration of the GI tract by a fish bone was treated by laparotomy. DBE is a useful procedure for removal of a foreign body from the small bowel... - Gastrointestinal hemorrhage as the first manifestation of metastatic extragonadal choriocarcinomaTomoyoshi Shibuya
Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
Intern Med 48:551-4. 2009..Based on these results, our diagnosis was extragonadal retroperitoneal germ cell tumor with gastric metastasis... - Zinc L-carnosine protects against mucosal injury in portal hypertensive gastropathy through induction of heat shock protein 72Ken-Ichiro Mikami
Department of Gastroenterology, Akita University School of Medicine, Akita, Japan
J Gastroenterol Hepatol 21:1669-74. 2006..It is postulated that zinc L-carnosine may be beneficial to the mucosal protection in PHG as a 'chaperone inducer'... - Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cellsKoga Komatsu
Department of Gastroenterology, Honjo Daiichi General Hospital, Yurihonjo, Japan
Mol Cancer 5:63. 2006..To define the genetic changes that occur during this process, we used oligonucleotide microarrays to determine which genes are regulated following the constitutive activation of MEK in normal intestinal epithelial cells... - Metastatic renal cell carcinoma diagnosed by capsule endoscopy and double balloon endoscopyTsutomu Takeda
Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
Med Sci Monit 17:CS15-7. 2011..Renal cell carcinoma commonly metastasizes to lung, liver, and bone. Small intestinal metastases are exceedingly rare... - Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2A adenosine receptor in ratsMasaru Odashima
Department of Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
World J Gastroenterol 12:568-73. 2006..To determine whether a specific adenosine A(2A) receptor agonist (ATL-146e) can ameliorate aspirin-induced gastric mucosal lesions in rats, and reduce neutrophil accumulation and production of pro-inflammatory cytokines... - Selective A2A adenosine agonist ATL-146e attenuates acute lethal liver injury in miceMasaru Odashima
Department of Gastroenterology, Akita University School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan
J Gastroenterol 40:526-9. 2005..CONCLUSION: The present findings suggest that the highly selective adenosine A2A receptor agonist (ATL-146e) prevents endotoxin-induced lethal liver injury by suppression of TNF-alpha secretion...