Michiro Otaka

Summary

Affiliation: Juntendo University School of Medicine
Country: Japan

Publications

  1. doi request reprint Overexpression of a 60-kDa heat shock protein enhances cytoprotective function of small intestinal epithelial cells
    Makiko Takada
    Department of Gastroenterology, Juntendo University School of Medicine, Japan
    Life Sci 86:499-504. 2010
  2. doi request reprint Expression and function of stress (heat shock) proteins in gastrointestinal tract
    Michiro Otaka
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Int J Hyperthermia 25:634-40. 2009
  3. pmc Acute variceal bleeding in a patient with idiopathic myelofibrosis successfully treated with endoscopic variceal band ligation and chemotherapy: a case report
    Kumiko Tamaki
    Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    J Med Case Reports 4:25. 2010
  4. doi request reprint Target molecules of molecular chaperone (HSP70 family) in injured gastric mucosa in vivo
    Michiro Otaka
    Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Life Sci 84:664-7. 2009
  5. doi request reprint Colonic mucosal lesions associated with low-dose aspirin: a case control study
    Tomoyoshi Shibuya
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Scand J Gastroenterol 46:810-7. 2011
  6. ncbi request reprint Attenuation of gastric mucosal inflammation induced by aspirin through inhibition of selective type III phospshodiesterase in rats
    Masaru Odashima
    Department of Gastroenterology, Akita University of Medicine, 1 1 1, Hondo, Akita City, 010 8543, Akita, Japan
    Dig Dis Sci 52:1355-9. 2007
  7. doi request reprint Clinicopathological characteristics of colorectal cancer less than 10 mm in diameter and invading submucosa and below
    Kazuko Beppu
    Department of Gastroenterology, School of Medicine, Juntendo University, Tokyo, Japan
    J Gastroenterol Hepatol 25:S57-61. 2010
  8. ncbi request reprint Relationship between endoscopic findings and clinical severity in ischemic colitis
    Kazuko Beppu
    Department of Gastroenterology, Juntendo University, School of Medicine, Japan
    Intern Med 50:2263-7. 2011
  9. pmc Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats
    Shigeto Koizumi
    Department of Gastroenterology, Akita University School of Medicine, Akita, Japan
    J Gastroenterol 44:419-25. 2009
  10. ncbi request reprint Gastrointestinal tuberculosis as a cause of massive bleeding
    Kazuko Beppu
    Department of Gastroenterology, Juntendo University, School of Medicine, Tokyo, Japan
    Med Sci Monit 15:CS151-154. 2009

Collaborators

Detail Information

Publications34

  1. doi request reprint Overexpression of a 60-kDa heat shock protein enhances cytoprotective function of small intestinal epithelial cells
    Makiko Takada
    Department of Gastroenterology, Juntendo University School of Medicine, Japan
    Life Sci 86:499-504. 2010
    ..In this study, we examined the effect of HSP60 or HSP70 overexpression on hydrogen peroxide-induced (H2O2) or indomethacin-induced cell damage in the small intestinal epithelial cells...
  2. doi request reprint Expression and function of stress (heat shock) proteins in gastrointestinal tract
    Michiro Otaka
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Int J Hyperthermia 25:634-40. 2009
    ..In addition, these findings in post-genomic level may provide new strategies for the therapy of gastrointestinal disorders...
  3. pmc Acute variceal bleeding in a patient with idiopathic myelofibrosis successfully treated with endoscopic variceal band ligation and chemotherapy: a case report
    Kumiko Tamaki
    Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    J Med Case Reports 4:25. 2010
    ..Gastrointestinal hemorrhages, which are due mostly to the rupture of the esophageal varices, have been sporadically reported to be an infrequent complication of idiopathic myelofibrosis...
  4. doi request reprint Target molecules of molecular chaperone (HSP70 family) in injured gastric mucosa in vivo
    Michiro Otaka
    Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Life Sci 84:664-7. 2009
    ..In the present study, gastric mucosal proteins that specifically bind to the HSP70 family (HSC70) were analyzed using HSC70-affinity chromatography...
  5. doi request reprint Colonic mucosal lesions associated with low-dose aspirin: a case control study
    Tomoyoshi Shibuya
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Scand J Gastroenterol 46:810-7. 2011
    ..Recently, there has been a substantial increase in prescriptions for LDA. We analyzed the risk of colonic mucosal lesions associated with the long-term use of LDA...
  6. ncbi request reprint Attenuation of gastric mucosal inflammation induced by aspirin through inhibition of selective type III phospshodiesterase in rats
    Masaru Odashima
    Department of Gastroenterology, Akita University of Medicine, 1 1 1, Hondo, Akita City, 010 8543, Akita, Japan
    Dig Dis Sci 52:1355-9. 2007
    ..Cilostazol may be useful for preventing gastric mucosal lesions induced by aspirin...
  7. doi request reprint Clinicopathological characteristics of colorectal cancer less than 10 mm in diameter and invading submucosa and below
    Kazuko Beppu
    Department of Gastroenterology, School of Medicine, Juntendo University, Tokyo, Japan
    J Gastroenterol Hepatol 25:S57-61. 2010
    ..This study examines the clinicopathological characteristics of colorectal cancers less than 10 mm in diameter and invading submucosal layer (SM)3 and below, which require surgery and must never be treated by endoscopic mucosal resection...
  8. ncbi request reprint Relationship between endoscopic findings and clinical severity in ischemic colitis
    Kazuko Beppu
    Department of Gastroenterology, Juntendo University, School of Medicine, Japan
    Intern Med 50:2263-7. 2011
    ..The incidence of ischemic colitis (IC) in Japan has been increasing due to the westernization of diet and the aging population. The aim of this study was to evaluate the relationship between endoscopic findings and clinical severity in IC...
  9. pmc Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats
    Shigeto Koizumi
    Department of Gastroenterology, Akita University School of Medicine, Akita, Japan
    J Gastroenterol 44:419-25. 2009
    ....
  10. ncbi request reprint Gastrointestinal tuberculosis as a cause of massive bleeding
    Kazuko Beppu
    Department of Gastroenterology, Juntendo University, School of Medicine, Tokyo, Japan
    Med Sci Monit 15:CS151-154. 2009
    ..Although minor bleeding is fairly common among cases of gastrointestinal tuberculosis, massive hemorrhage necessitating blood transfusion is rare...
  11. doi request reprint Specific induction of a 72-kDa heat shock protein protects esophageal mucosa from reflux esophagitis
    Yuko Izumi
    Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Life Sci 84:517-22. 2009
    ..The aim of this study is to investigate the expression and cytoprotective function of a 72-kDa heat shock protein (HSP72) using a reflux esophagitis model in rats...
  12. ncbi request reprint A selective adenosine A2A receptor agonist, ATL-146e, prevents concanavalin A-induced acute liver injury in mice
    Masaru Odashima
    Department of Gastroenterology, Akita University School of Medicine, Akita, Japan
    Biochem Biophys Res Commun 347:949-54. 2006
    ..The aim of the present study was to determine whether ATL-146e could ameliorate Con A-induced hepatic injury, reduction of pro-inflammatory cytokine production...
  13. ncbi request reprint Zinc L-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-kappaB activation
    Masaru Odashima
    Department of Gastroenterology, Akita University School of Medicine, 1 1 1, Hondo, Akita City, Akita 010 8543, Japan
    Life Sci 79:2245-50. 2006
    ....
  14. doi request reprint Establishment of a reflux esophago-laryngitis model in rats
    Daisuke Asaoka
    Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1, Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Dig Dis Sci 56:1299-308. 2011
    ..To investigate the pathophysiology of reflux laryngitis, an experimental model is required...
  15. doi request reprint Colonic mucosal lesions associated with long-term or short-term administration of nonsteroidal anti-inflammatory drugs
    Tomoyoshi Shibuya
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Colorectal Dis 12:1113-21. 2010
    ..We assessed the risk of developing colonic mucosal lesions according to the duration of exposure to NSAIDs: short-term and/or long-term use...
  16. pmc Characteristic pathological findings and effects of ecabet sodium in rat reflux esophagitis
    Daisuke Asaoka
    Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1, Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    World J Gastroenterol 15:3480-5. 2009
    ..To explore the pathological findings in the entire esophagus in rats with reflux esophagitis, and the effects of ecabet sodium (ES)...
  17. ncbi request reprint Successful treatment of refractory duodenal Crohn's disease with infliximab
    Masaru Odashima
    Department of Gastroenterology, Akita University of Medicine, 1 1 1, Hondo, Akita City, Akita 010 8543, Japan
    Dig Dis Sci 52:31-2. 2007
  18. doi request reprint Observational comparative trial of the efficacy of proton pump inhibitors versus histamine-2 receptor antagonists for uninvestigated dyspepsia
    Akihito Nagahara
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    J Gastroenterol Hepatol 25:S122-8. 2010
    ..It is still controversial which drugs, proton pump inhibitors (PPI) or histamine-2 receptor antagonists (H2RA), are more effective for dyspepsia in the Japanese population...
  19. ncbi request reprint Hamartomatous inverted polyp successfully treated by endoscopic submucosal dissection
    Masaru Odashima
    Department of Gastroenterology, Akita University School of Medicine, Akita, Japan
    Intern Med 47:259-62. 2008
    ..ESD method may be indicated for SMT-type hamartomatous inverted polyps...
  20. pmc Correlation of heat shock protein expression to gender difference in development of stress-induced gastric mucosal injury in rats
    Taiji Takahashi
    Department of Gastroenterology, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    J Clin Biochem Nutr 47:64-73. 2010
    ..Our results suggested that estrogen might play an important role in gastric mucosal protection with the induction of gastric mucosal HSPs...
  21. doi request reprint Comparison of several activity indices for the evaluation of endoscopic activity in UC: inter- and intraobserver consistency
    Taro Osada
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Inflamm Bowel Dis 16:192-7. 2010
    ..This study evaluated inter- and intraobserver agreement in the assessment of ulcerative colitis (UC) activity using 4 established indices and a newly designed Modified 6-point Activity Index...
  22. doi request reprint Endoscopic submucosal dissection of large colorectal tumors by using a novel spring-action S-O clip for traction (with video)
    Naoto Sakamoto
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Gastrointest Endosc 69:1370-4. 2009
    ..In this report, we describe a novel spring-action version of the S-O clip (spring S-O clip) that improves the facility of clip use during ESD of colorectal tumors...
  23. ncbi request reprint Mechanical strain stress suppresses expression of HSP70 and wound restoration in gastric mucosal cells
    Masaru Odashima
    Department of Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Dig Dis Sci 52:3087-91. 2007
    ..On the other hand, the wound restoration of 7018-RGM-1 cells was not affected by mechanical stretch. These results suggest that HSP70 plays an important role in gastric wound healing under physical stress...
  24. ncbi request reprint The relationship between physical activity level and completion rate of small bowel examination in patients undergoing capsule endoscopy
    Tomoyoshi Shibuya
    Department of Gastroenterology, Juntendo University School of Medicine, Japan
    Intern Med 51:997-1001. 2012
    ..Attempts to improve the completion rate (CR) as defined by reaching the cecum have been unsuccessful. This study was to investigate the relationship between patients' physical activity and CR...
  25. pmc Traditional Herbal Medicine, Rikkunshito, Induces HSP60 and Enhances Cytoprotection of Small Intestinal Mucosal Cells as a Nontoxic Chaperone Inducer
    Kumiko Tamaki
    Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Evid Based Complement Alternat Med 2012:278958. 2012
    ..Our results suggested that HSP60 induced by TJ-43 might play an important role in protecting small intestinal epithelial cells from apoptosis and necrosis in vitro...
  26. doi request reprint Evidence for enhanced cytoprotective function of HSP90-overexpressing small intestinal epithelial cells
    Kumiko Tamaki
    Department of Gastroenterology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Dig Dis Sci 56:1954-61. 2011
    ....
  27. ncbi request reprint Double-balloon endoscopy for treatment of long-term abdominal discomfort due to small bowel penetration by an eel bone
    Tomoyoshi Shibuya
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Med Sci Monit 14:CS107-9. 2008
    ..Penetration of the GI tract by a fish bone was treated by laparotomy. DBE is a useful procedure for removal of a foreign body from the small bowel...
  28. ncbi request reprint Gastrointestinal hemorrhage as the first manifestation of metastatic extragonadal choriocarcinoma
    Tomoyoshi Shibuya
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Intern Med 48:551-4. 2009
    ..Based on these results, our diagnosis was extragonadal retroperitoneal germ cell tumor with gastric metastasis...
  29. ncbi request reprint Large Brunner's gland hyperplasia treated with modified endoscopic submucosal dissection
    Reina Ohba
    Department of Gastroenterology, Akita University School of Medicine, 1 1 1, Hondo, Akita City, Akita 010 8543, Japan
    Dig Dis Sci 52:170-2. 2007
  30. pmc Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells
    Koga Komatsu
    Department of Gastroenterology, Honjo Daiichi General Hospital, Yurihonjo, Japan
    Mol Cancer 5:63. 2006
    ..To define the genetic changes that occur during this process, we used oligonucleotide microarrays to determine which genes are regulated following the constitutive activation of MEK in normal intestinal epithelial cells...
  31. ncbi request reprint Zinc L-carnosine protects against mucosal injury in portal hypertensive gastropathy through induction of heat shock protein 72
    Ken Ichiro Mikami
    Department of Gastroenterology, Akita University School of Medicine, Akita, Japan
    J Gastroenterol Hepatol 21:1669-74. 2006
    ..In this study, the effects of zinc L-carnosine, an anti-ulcer drug, were evaluated on expression of heat shock protein (hsp) 72 and cytoprotection in gastric mucosa in a rat model of PHG...
  32. pmc Metastatic renal cell carcinoma diagnosed by capsule endoscopy and double balloon endoscopy
    Tsutomu Takeda
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
    Med Sci Monit 17:CS15-7. 2011
    ..Renal cell carcinoma commonly metastasizes to lung, liver, and bone. Small intestinal metastases are exceedingly rare...
  33. ncbi request reprint Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2A adenosine receptor in rats
    Masaru Odashima
    Department of Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    World J Gastroenterol 12:568-73. 2006
    ..To determine whether a specific adenosine A(2A) receptor agonist (ATL-146e) can ameliorate aspirin-induced gastric mucosal lesions in rats, and reduce neutrophil accumulation and production of pro-inflammatory cytokines...
  34. ncbi request reprint Selective A2A adenosine agonist ATL-146e attenuates acute lethal liver injury in mice
    Masaru Odashima
    Department of Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    J Gastroenterol 40:526-9. 2005
    ..We examined the effects of a highly selective adenosine A2A receptor agonist (ATL-146e) on GalN/LPS-induced fulminant hepatic failure...