Kazuo Oshimi

Summary

Affiliation: Juntendo University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint NK-cell neoplasms in Japan
    Kazuo Oshimi
    Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
    Hematology 10:237-45. 2005
  2. ncbi request reprint Progress in understanding and managing natural killer-cell malignancies
    Kazuo Oshimi
    Department of Haematology, Juntendo University School of Medicine, Tokyo, Japan
    Br J Haematol 139:532-44. 2007
  3. ncbi request reprint Leukemia and lymphoma of natural killer lineage cells
    Kazuo Oshimi
    Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
    Int J Hematol 78:18-23. 2003
  4. ncbi request reprint [Diffuse large B-cell lymphoma expressing surface immunoglobulin heavy chain (Ig alpha) and lacking light chains]
    Miki Ando
    Department of Hematology, Juntendo University School of Medicine
    Rinsho Ketsueki 46:492-5. 2005
  5. doi request reprint Absence of tumor-specific over-expression of Polo-like kinase 1 (Plk1) in major non-Hodgkin lymphoma and relatively low expression of Plk1 in nasal NK/T cell lymphoma
    Hidenori Imai
    Department of Internal Medicine, Division of Hematology, Juntendo University School of Medicine, Tokyo, Japan
    Int J Hematol 89:673-8. 2009
  6. doi request reprint Aggressive natural killer cell leukemia: therapeutic potential of L-asparaginase and allogeneic hematopoietic stem cell transplantation
    Fumihiro Ishida
    Department of Hematology, Shinshu University School of Medicine, Matsumoto, Japan
    Cancer Sci 103:1079-83. 2012
  7. ncbi request reprint Clinical analysis of 52 patients with granular lymphocyte proliferative disorder (GLPD) showed frequent anemia in indolent T-cell GLPD in Japan
    Shimpei Kawahara
    Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Eur J Haematol 82:308-14. 2009
  8. ncbi request reprint Progressive respiratory distress in a patient with splenic marginal zone lymphoma
    Azuchi Masuda
    Division of Hematology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Intern Med 47:1281-2. 2008
  9. doi request reprint Expression levels of apoptosis-related proteins and Ki-67 in nasal NK / T-cell lymphoma
    Hajime Yasuda
    Division of Hematology, Department of Medicine, Juntendo University School of Medicine, Tokyo
    Eur J Haematol 82:39-45. 2009
  10. ncbi request reprint Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders
    Norihiko Kawamata
    Division of Hematology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Eur J Haematol 74:424-9. 2005

Detail Information

Publications66

  1. ncbi request reprint NK-cell neoplasms in Japan
    Kazuo Oshimi
    Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
    Hematology 10:237-45. 2005
    ..In nasal NK-cell lymphoma, Epstein-Barr virus in tumor cells was detected in all patients tested, suggesting its causative role...
  2. ncbi request reprint Progress in understanding and managing natural killer-cell malignancies
    Kazuo Oshimi
    Department of Haematology, Juntendo University School of Medicine, Tokyo, Japan
    Br J Haematol 139:532-44. 2007
    ..Aggressive NK-cell leukaemia is rare and has a poor prognosis. Because NK-cell neoplasms are rare and difficult to manage, rigorous studies are required for their understanding and management...
  3. ncbi request reprint Leukemia and lymphoma of natural killer lineage cells
    Kazuo Oshimi
    Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
    Int J Hematol 78:18-23. 2003
    ..Because NK cell tumors are rare and difficult to manage, vigorous studies are required for their understanding and management...
  4. ncbi request reprint [Diffuse large B-cell lymphoma expressing surface immunoglobulin heavy chain (Ig alpha) and lacking light chains]
    Miki Ando
    Department of Hematology, Juntendo University School of Medicine
    Rinsho Ketsueki 46:492-5. 2005
    ..After five courses of biweekly CHOP chemotherapy, she received autologous peripheral blood stem cell transplantation in October 2000. Currently, she has maintained complete remission for more than 4 years...
  5. doi request reprint Absence of tumor-specific over-expression of Polo-like kinase 1 (Plk1) in major non-Hodgkin lymphoma and relatively low expression of Plk1 in nasal NK/T cell lymphoma
    Hidenori Imai
    Department of Internal Medicine, Division of Hematology, Juntendo University School of Medicine, Tokyo, Japan
    Int J Hematol 89:673-8. 2009
    ..The 4-year overall survival rates by Kaplan-Meier analysis for Plk1-negative and positive patients were 80 and 38%, respectively (p = 0.02)...
  6. doi request reprint Aggressive natural killer cell leukemia: therapeutic potential of L-asparaginase and allogeneic hematopoietic stem cell transplantation
    Fumihiro Ishida
    Department of Hematology, Shinshu University School of Medicine, Matsumoto, Japan
    Cancer Sci 103:1079-83. 2012
    ..33, 95% confidence interval; 0.13-0.83, P = 0.02). Early diagnosis of ANKL, l-asparaginase-based chemotherapy and allogeneic HSCT might lead to improved patient outcomes...
  7. ncbi request reprint Clinical analysis of 52 patients with granular lymphocyte proliferative disorder (GLPD) showed frequent anemia in indolent T-cell GLPD in Japan
    Shimpei Kawahara
    Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Eur J Haematol 82:308-14. 2009
    ..The present analysis of 52 cases of GLPD in Japan showed that Japanese and Western cases of indolent T-GLPD clearly differ in their hematological complications...
  8. ncbi request reprint Progressive respiratory distress in a patient with splenic marginal zone lymphoma
    Azuchi Masuda
    Division of Hematology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Intern Med 47:1281-2. 2008
  9. doi request reprint Expression levels of apoptosis-related proteins and Ki-67 in nasal NK / T-cell lymphoma
    Hajime Yasuda
    Division of Hematology, Department of Medicine, Juntendo University School of Medicine, Tokyo
    Eur J Haematol 82:39-45. 2009
    ..Nasal natural killer (NK)/T-cell lymphoma is characterized by chemo-resistance, angiodestruction, and aggressive tumor progression. Few studies exist on molecular characteristics of this disease entity...
  10. ncbi request reprint Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders
    Norihiko Kawamata
    Division of Hematology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Eur J Haematol 74:424-9. 2005
    ..These results suggested that inactivation of the cell cycle regulatory genes by DNA methylation could be associated with tumorigenesis in NK cell disorders, not only aggressive subtypes but also chronic subtype...
  11. ncbi request reprint Changes in cell morphology and cytoskeletal organization are induced by human mitotic checkpoint gene, Bub1
    Jun Ando
    Division of Haematology, Department of Internal Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, 113 8421 Tokyo, Japan
    Biochem Biophys Res Commun 365:691-7. 2008
    ..These observations suggest that Bub1 not only regulates the cell cycle, but also may be involved in the cytoskeletal control in interphase cells...
  12. doi request reprint Chronic lymphocytic leukemia in a Japanese population: varied immunophenotypic profile, distinctive usage of frequently mutated IGH gene, and indolent clinical behavior
    Junichi Tomomatsu
    Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
    Leuk Lymphoma 51:2230-9. 2010
    ..Although Japanese cases of CLL showed heterogeneity in morphology and immunophenotype, most cases arose from post-antigen-selected B cells and presented with indolent clinical behavior...
  13. doi request reprint Effective treatment of a refractory hairy cell leukemia variant with splenic pre-irradiation and alemtuzumab
    Makoto Sasaki
    Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Acta Haematol 119:48-53. 2008
    ..This is the first report showing clinical effectiveness of splenic irradiation and alemtuzumab against refractory HCLv...
  14. ncbi request reprint Selective apoptosis of natural killer-cell tumours by l-asparaginase
    Miki Ando
    Department of Haematology, Juntendo University School of Medicine, Tokyo, Japan
    Br J Haematol 130:860-8. 2005
    ..We confirmed rather specific anti-tumour activity of l-asparaginase against NK-cell tumours in vitro, which provides an experimental background to the clinical use of l-asparaginase for NK-cell tumours...
  15. ncbi request reprint Neural cell adhesion molecule (CD56)-positive B-cell lymphoma
    Yasushi Isobe
    Department of Hematology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Eur J Haematol 79:166-9. 2007
    ..Although CD56 expression level varies among the cases, this molecule might play some roles in the manner of growth and expansion of CD56-positive B-cell lymphomas...
  16. ncbi request reprint Epstein-Barr virus infection of human natural killer cell lines and peripheral blood natural killer cells
    Yasushi Isobe
    Division of Hematology, Department of Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Cancer Res 64:2167-74. 2004
    ..We first report in vitro EBV infection of human NK cells and establishment of EBV-carrying NK clones, which should contribute to elucidate the role of EBV in the development of NK cell neoplasms...
  17. ncbi request reprint Successful high-titer immunoglobulin therapy for persistent parvovirus B19 infection in a lymphoma patient treated with rituximab-combined chemotherapy
    Yasushi Isobe
    Division of Hematology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Am J Hematol 77:370-3. 2004
    ..We propose that the use of high-titer immunoglobulin against parvovirus B19 may enable such immunocompromised patients to eradicate the virus before sufficient immune system reconstruction...
  18. doi request reprint Activity and safety of combination chemotherapy with methotrexate, ifosfamide, l-asparaginase and dexamethasone (MILD) for refractory lymphoid malignancies: a pilot study
    Yutaka Tsukune
    Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
    Eur J Haematol 84:310-5. 2010
    ..MILD therapy was feasible and presented acceptable toxicity in patients with refractory or lethal lymphoid malignancies. The efficacy for T/NK-cell malignancies should be further evaluated...
  19. ncbi request reprint Enteropathy-type T-cell lymphoma expressing NK-cell intraepithelial lymphocyte (NK-IEL) phenotype
    Naoko Inagaki
    Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
    Leuk Lymphoma 45:1471-4. 2004
    ..Because Southern blotting analysis showed a rearrangement of T-cell receptor (TCR) Cbeta in this case, the tumor is classified as an ETL. Based on the findings, NK-IELs may originate from T-cells, not NK-cells...
  20. ncbi request reprint Pure red cell aplasia associated with expansion of CD3+ CD8+ granular lymphocytes expressing cytotoxicity against HLA-E+ cells
    Kiyoshi L Mori
    Department of Haematology, Juntendo University School of Medicine, Tokyo, Japan
    Br J Haematol 123:147-53. 2003
    ..GLs of T-GLPD with PRCA have a potential positive activity against HLA-E+ cells, whereas GLs from T-GLPD without PRCA do not. CD94 may play a key role in the pathogenesis of PRCA in T-GLPD...
  21. ncbi request reprint B-cell marker negative (CD7+, CD19-) Epstein-Barr virus-related pyothorax-associated lymphoma with rearrangement in the JH gene
    Shigehisa Tomita
    Department of Hematology, Juntendo University School of Medicine, 2 1 1, Hongo Bunkyo ku, Tokyo, 113 8421 Japan
    Leuk Lymphoma 44:727-30. 2003
    ..Chromosomal abnormality of the lymphoma was complicated. It suggested that many transformations occurred. In the transformation process, probably B-cell antigens were lost, and T-cell antigens were aberrantly expressed...
  22. doi request reprint Identification of Bcl-2/IgH fusion sequences using real-time PCR and chip-based microcapillary electrophoresis
    Yoko Tabe
    Department of Clinical Laboratory Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Clin Chem Lab Med 49:809-15. 2011
    ..The determination of polymerase chain reaction (PCR) amplification product sizes of the Bcl-2/IgH fusion gene from follicular lymphoma (FL) provides evidence of clonal identity...
  23. ncbi request reprint More than 13 years of hypereosinophila associated with clonal CD3-CD4+ lymphocytosis of TH2/TH0 type
    Koichi Sugimoto
    Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Int J Hematol 75:281-4. 2002
    ....
  24. ncbi request reprint Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3
    Atsushi Kato
    Division of Hematology, Department of Internal Medicine and Division of Biochemical Analysis, Central Laboratory of Medical Sciences, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 277:28934-41. 2002
    ..As Aup1 possesses domains related to signal transduction, these results suggest involvement of Aup1 in the integrin signaling...
  25. ncbi request reprint Mononucleosis syndrome and acute monocytic leukemia
    Kenji Tamayose
    Department of Hematolgy, Juntendo University School of Medicine, Tokyo, Japan
    Eur J Haematol 68:236-8. 2002
    ..Mononuclear leukocytes appearing during the mononucleosis syndrome were very similar to the initial leukemic cells. Varicella zoster virus mononucleosis syndrome was confirmed by delayed herpes zoster rash with dermatomal distribution...
  26. ncbi request reprint Low-dose doxorubicin-induced necrosis in Jurkat cells and its acceleration and conversion to apoptosis by antioxidants
    Koichi Sugimoto
    Department of Haematology, Juntendo University School of Medicine, Tokyo, Japan
    Br J Haematol 118:229-38. 2002
    ..Some of the prenecrotic cells, therefore, might survive and obtain genomic instability. Antioxidants may be useful to suppress, at least to some extent, this vicious consequence...
  27. ncbi request reprint A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute lymphoblastic leukemia involves the LIM homeodomain protein gene, Lhx4
    Norihiko Kawamata
    Division of Hematology, Department of Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Oncogene 21:4983-91. 2002
    ..The Lhx4 gene is deregulated in the leukemic cells and Lhx4 protein may play an important role, possibly as an activator, in leukemogenesis...
  28. ncbi request reprint CD3-negative, CD20-positive T-cell prolymphocytic leukemia: case report and review of the literature
    Kenji Tamayose
    Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
    Am J Hematol 71:331-5. 2002
    ..Splenomegaly was a common feature. However, our case alone had "bright" CD20 expression on the leukemic cells. This is the first report of CD20(+) T-PLL...
  29. ncbi request reprint Treatment of acute myeloid leukemia patients aged more than 75 years: results of the E-AML-01 trial of the Japanese Elderly Leukemia and Lymphoma Study Group (JELLSG)
    Mayumi Mori
    Division of Hematology, Tokyo Metropolitan Geriatric Hospital, Sakaecho, Tokyo, Japan
    Leuk Lymphoma 47:2062-9. 2006
    ..0% and disease-free survival at 2 and 5 years was 21.0% and 11.2%, respectively. The therapy-related mortality rate at induction was 13.8%. BHAC-DM is feasible and effective for selected very elderly acute myeloid leukemia patients...
  30. ncbi request reprint Improvement of idiopathic thrombocytopenic purpura by antithyroid therapy
    Koichi Sugimoto
    Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Eur J Haematol 74:73-4. 2005
    ....
  31. ncbi request reprint [A clinical study of intraocular malignant lymphoma]
    Aki Ohta
    Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
    Nihon Ganka Gakkai Zasshi 110:588-93. 2006
    ..We investigated whether vitreous cytology and the measurement of intravitreous cytokine were useful for the diagnosis of intraocular malignant lymphoma...
  32. doi request reprint Lymphomatoid gastropathy: a distinct clinicopathologic entity of self-limited pseudomalignant NK-cell proliferation
    Kengo Takeuchi
    The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Blood 116:5631-7. 2010
    ..However, LyGa is recognized as a pseudomalignant process because of its clinical characteristics. The concept of LyGa should be well recognized...
  33. ncbi request reprint Extensive bone marrow necrosis and symptomatic hypercalcemia in B cell blastic transformation of chronic myeloid leukemia: report of a case and review of the literature
    Masaaki Noguchi
    Department of Hematology, Juntendo Urayasu Hospital, Urayasu shi, Chiba, Japan
    Acta Haematol 118:111-6. 2007
    ..As far as we know, this is the first case report of chronic myeloid leukemia concurrently developing bone marrow necrosis and hypercalcemia; this association was not reported in other types of leukemia or bone marrow malignancies...
  34. ncbi request reprint Severe pulmonary complications in Japanese patients after bortezomib treatment for refractory multiple myeloma
    Shigesaburo Miyakoshi
    Department of Hematology, Toranomon Hospital, 2 2 2, Toranomon, Tokyo, Japan
    Blood 107:3492-4. 2006
    ..Our study suggests that bortezomib can cause serious lung injury, and that its incidence might vary among different ethnicities. Clinicians need to be alert to the possibility...
  35. ncbi request reprint [Zygomycosis: two case reports and review of reported cases in the literature in Japan]
    Takeshi Mori
    Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Nihon Ishinkin Gakkai Zasshi 44:163-79. 2003
    ..Five cases with allergic zygomycosis were all alive. There were only 14 cases in which isolated fungi were identified (Cunninghamella spp. from 5 cases, Mucor spp. from 2, Rhizomucor spp. from 2, and Rhizopus spp. from 5)...
  36. ncbi request reprint Molecular analysis of oncogenes, ras family genes (N-ras, K-ras, H-ras), myc family genes (c-myc, N-myc) and mdm2 in natural killer cell neoplasms
    Kei Ji Sugimoto
    Division of Hematology, Department of Medicine, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Jpn J Cancer Res 93:1270-7. 2002
    ..In contrast, overexpression of MDM2 might be associated with tumorigenesis of NK cell neoplasms, especially aggressive subclasses...
  37. ncbi request reprint Ancient ubiquitous protein 1 and Syk link cytoplasmic tails of the integrin alpha(IIb)beta(3)
    Atsushi Kato
    Division of Hematology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Platelets 20:105-10. 2009
    ....
  38. doi request reprint Clinical features of adult acute leukemia with 11q23 abnormalities in Japan: a co-operative multicenter study
    Hayato Tamai
    Department of Hematology, Nippon Medical School, Sendagi 1 1 5, Bunkyo ku, Tokyo, Japan
    Int J Hematol 87:195-202. 2008
    ..However, further studies involving a large number of cases are required to assess the effect of allo-HSCT on adult AL with 11q23 abnormalities...
  39. ncbi request reprint Intravascular large B-cell lymphoma
    Keiji J Sugimoto
    Department of Hematology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Am J Hematol 76:291-2. 2004
  40. pmc Hepatocyte growth factor receptor is a coreceptor for adeno-associated virus type 2 infection
    Yuji Kashiwakura
    Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan
    J Virol 79:609-14. 2005
    ..These data suggest that c-Met plays the role of coreceptor for AAV2 infection by facilitating AAV2 internalization into the cytoplasm...
  41. ncbi request reprint Epstein-Barr virus-associated T-cell acute lymphoblastic leukaemia
    Sakura Sakajiri
    Division of Hematology, Department of Medicine, Juntendo University School of Medicine, Hongo, Bunkyo ku, Tokyo, Japan
    Br J Haematol 117:127-9. 2002
    ..The leukaemic cells, massively infiltrated into the liver and spleen, were resistant to chemotherapy. EBV might be associated with tumorigenesis of T-ALL, and characteristic clinical features of the patient...
  42. ncbi request reprint NK cell lymphoma
    Kazuo Oshimi
    Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
    Int J Hematol 76:118-21. 2002
    ..These findings may change the treatment strategy. Finally, I will present the results on interim analysis of 166 cases of nasal-type NK-cell lymphoma collected in Japan between 1994 and 1998...
  43. ncbi request reprint Late appearance of t(1;19)(q11;q11) in myelodysplastic syndrome associated with dysplastic eosinophilia and pulmonary alveolar proteinosis
    Jun Ando
    Department of Hematology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Cancer Genet Cytogenet 139:14-7. 2002
    ..We postulate that this chromosomal rearrangement is involved in the development of eosinophilia and pulmonary alveolar proteinosis in MDS...
  44. ncbi request reprint Multifocal motor neuropathy caused by a B-cell lymphoma producing a monoclonal IgM autoantibody against peripheral nerve myelin glycolipids GM1 and GD1b
    Masaaki Noguchi
    Department of Haematology, Juntendo University School of Medicine, Tokyo, Japan
    Br J Haematol 123:600-5. 2003
    ..This antibody bound to glycolipids GM1 and GD1b in peripheral motor nerve myelin, presumably initiating formation of destructive immune complexes that caused multifocal motor neuropathy...
  45. ncbi request reprint Epstein-Barr virus-positive Hodgkin's lymphoma in a patient with chronic active Epstein-Barr virus infection
    Kenji Tamayose
    Int J Hematol 80:199-200. 2004
  46. doi request reprint CD20-positive extranodal NK-cell lymphoma, nasal-type
    Jun Ando
    Eur J Haematol 80:549-50. 2008
  47. ncbi request reprint [Case of malignant lymphoma arising from the posterior mediastinum, with pleural effusion]
    Osamu Nagashima
    Department of Respiratory Medicine, Juntendo University School of Medicine
    Nihon Kokyuki Gakkai Zasshi 42:772-6. 2004
    ..A diagnosis of diffuse large B cell lymphoma was made from the typical histological features. The patient was treated with combination chemotherapy (CHOP) and rituximab and improved dramatically...
  48. ncbi request reprint T-gamma delta LGL leukemia with complications
    Kazuo Oshimi
    Intern Med 45:707-8. 2006
  49. ncbi request reprint Epstein-Barr virus (EBV)-encoded RNA promotes growth of EBV-infected T cells through interleukin-9 induction
    Lixin Yang
    Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita ku, Sapporo 060 0815, Japan
    Cancer Res 64:5332-7. 2004
    ..Analysis of nasal lymphoma biopsies indicated that three of four specimens expressed IL-9. The present findings suggest that EBV directly affects the pathogenesis of EBV-associated T-cell diseases...
  50. ncbi request reprint Retroviral expression screening of oncogenes in natural killer cell leukemia
    Young Lim Choi
    Division of Functional Genomics, Jichi Medical School, 3311 1 Yakushiji, Kawachigun, Tochigi 329 0498, Japan
    Leuk Res 29:943-9. 2005
    ..Mutation-specific PCR analysis indicated that the KRAS mutation was present only in KHYG-1 cells, not in another ANKL cell line or in clinical specimens (n=8)...
  51. ncbi request reprint Relationship between CD4(+)/CD8(+) T cell ratio and T cell activation in multiple myeloma: reference to IL-16
    Michiaki Koike
    Department of Internal Medicine, Juntendo University Izu Nagaoka Hospital, 1129 Nagaoka, Izu Nagaoka, Tagata gun, Shizuoka, Japan
    Leuk Res 26:705-11. 2002
    ..001). The decrease of CD4(+) T cells in MM may be mediated by activation of CD8(+) T cells derived cytokine IL-16. In addition, these T cell phenotypic changes and the IL-16 level appear to be useful indicators of disease activity...
  52. ncbi request reprint Nationwide survey of hemophagocytic lymphohistiocytosis in Japan
    Eiichi Ishii
    Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan
    Int J Hematol 86:58-65. 2007
    ..Although this nationwide survey establishes the heterogeneous characteristics of HLH, the results should be useful in planning prospective studies to identify the most effective therapy for each HLH subtype...
  53. ncbi request reprint [Acyclovir combined with plasma exchange for disseminated varicella-zoster virus infection after bone marrow transplantation]
    Chunyong Lee
    Department of Hematology, Juntendo University, Shizuoka Hospital
    Rinsho Ketsueki 47:210-3. 2006
    ..Acyclovir and plasma exchange rapidly controlled his VZV-related symptoms and signs. Disseminated VZV infection is often fatal, but acyclovir and plasma exchange may be useful for such infection by reducing the circulating viral load...
  54. ncbi request reprint Lung injury associated with bortezomib therapy in relapsed/refractory multiple myeloma in Japan: a questionnaire-based report from the "lung injury by bortezomib" joint committee of the Japanese society of hematology and the Japanese society of
    Akihiko Gotoh
    The Lung Injury by Bortezomib Joint Committee of the Japanese Society of Hematology and the Japanese Society of Clinical Hematology, Japan
    Int J Hematol 84:406-12. 2006
    ..Thus, future verification concerning this matter is warranted after the approval of bortezomib for use in Japan. Clinicians should be aware of the possibility of severe pulmonary complications associated with bortezomib therapy...
  55. ncbi request reprint [The chimerism and GVT effects on murine mini-transplantation model]
    Takao Hirano
    Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine
    Nihon Rinsho 61:1527-34. 2003
    ..The GVT effects were observed in both groups. However, GVT effects on G4 is stronger than that on G2 in pathological findings and serum IgE level...
  56. ncbi request reprint [Clinical aspect of lymphatic tumors]
    Kazuo Oshimi
    Nihon Naika Gakkai Zasshi 92:1838-41. 2003
  57. ncbi request reprint [Lung injury associated with bortezomib therapy in relapsed/refractory multiple myeloma in Japan: a questionnaire-based report from the "Lung Injury by Bortezomib" Joint Committee of the Japanese Society of Hematology and the Japanese Society of
    Akihiko Gotoh
    Rinsho Ketsueki 47:1521-7. 2006
    ..84, p406-412, 2006) by permission of both the editorials of the Japanese Society of Hematology and the Japanese Society of Clinical Hematology, and should be considered as the Japanese translation of the article...
  58. ncbi request reprint Cytokine-producing sarcoma mimics eosinophilic leukaemia
    Jun Ando
    Eur J Haematol 78:169-70. 2007
  59. ncbi request reprint Rapid elimination of circulating leukemia cells with a small dose of alemtuzumab in refractory aggressive NK-cell leukemia
    Makoto Sasaki
    Eur J Haematol 78:545. 2007
  60. ncbi request reprint [Treatment of chronic lymphocytic leukemia and NK-cell leukemia/lymphoma]
    Koichi Sugimoto
    Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine
    Nihon Rinsho 65:569-74. 2007
  61. ncbi request reprint Allogeneic haematopoietic stem cell transplantation as a promising treatment for natural killer-cell neoplasms
    Naoko Murashige
    Haematopoietic Stem Cell Transplantation Unit, the National Cancer Centre Hospital and Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Japan
    Br J Haematol 130:561-7. 2005
    ..03), age (>or=40 years vs. <40 years; relative risk 2.85), and diagnoses (extranodal NK/T-cell lymphoma versus others; relative risk 3.94) significantly affected PFS. Allo-HSCT is a promising treatment for NK-cell neoplasms...
  62. doi request reprint Combination brings long-term remission in acute promyelocytic leukemia refractory for both all-trans retinoic acid and arsenic trioxide
    Makoto Sasaki
    Eur J Haematol 81:160. 2008
  63. doi request reprint Phase I study of dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide (SMILE) chemotherapy for advanced-stage, relapsed or refractory extranodal natural killer (NK)/T-cell lymphoma and leukemia
    Motoko Yamaguchi
    Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Cancer Sci 99:1016-20. 2008
    ..Although its safety and efficacy require further evaluation, we recommend a SMILE chemotherapy dose level of 1 for further clinical studies...
  64. ncbi request reprint A multicenter analysis of the FIP1L1-alphaPDGFR fusion gene in Japanese idiopathic hypereosinophilic syndrome: an aberrant splicing skipping the alphaPDGFR exon 12
    Akiko Sada
    Hematology Oncology, Department of Medicine, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Ann Hematol 86:855-63. 2007
    ..Considering the relatively low incidence of the FIP1L1-alphaPDGFR transcript positive case, extreme care must therefore be taken when making a diagnosis using RT-PCR before imatinib therapy...
  65. ncbi request reprint Mxi1 isoforms are expressed in hematological cell lines and normal bone marrow
    Norihiko Kawamata
    Division of Hematology Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Int J Oncol 26:1369-75. 2005
    ....
  66. ncbi request reprint Blastic natural killer cell lymphoma/leukemia (CD56-positive blastic tumor): prognostication and categorization according to anatomic sites of involvement
    Ritsuro Suzuki
    Division of Molecular Medicine, Aichi Cancer Center, Nagoya, Japan
    Cancer 104:1022-31. 2005
    ..Blastic natural killer (NK) cell lymphoma/leukemia (BNKL) is an immature CD56-positive neoplasm, which was recognized recently and characterized by systemic proliferation of tumor cells including skin, lymph node, and bone marrow...