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Genomes and Genes | Kazuo OshimiSummaryAffiliation: Juntendo University School of Medicine Country: Japan Publications
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Publications
NK-cell neoplasms in JapanKazuo Oshimi
Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
Hematology 10:237-45. 2005..In nasal NK-cell lymphoma, Epstein-Barr virus in tumor cells was detected in all patients tested, suggesting its causative role...- Progress in understanding and managing natural killer-cell malignanciesKazuo Oshimi
Department of Haematology, Juntendo University School of Medicine, Tokyo, Japan
Br J Haematol 139:532-44. 2007..Aggressive NK-cell leukaemia is rare and has a poor prognosis. Because NK-cell neoplasms are rare and difficult to manage, rigorous studies are required for their understanding and management... - Leukemia and lymphoma of natural killer lineage cellsKazuo Oshimi
Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
Int J Hematol 78:18-23. 2003..Because NK cell tumors are rare and difficult to manage, vigorous studies are required for their understanding and management... - [Diffuse large B-cell lymphoma expressing surface immunoglobulin heavy chain (Ig alpha) and lacking light chains]Miki Ando
Department of Hematology, Juntendo University School of Medicine
Rinsho Ketsueki 46:492-5. 2005..After five courses of biweekly CHOP chemotherapy, she received autologous peripheral blood stem cell transplantation in October 2000. Currently, she has maintained complete remission for more than 4 years... 
Absence of tumor-specific over-expression of Polo-like kinase 1 (Plk1) in major non-Hodgkin lymphoma and relatively low expression of Plk1 in nasal NK/T cell lymphomaHidenori Imai
Department of Internal Medicine, Division of Hematology, Juntendo University School of Medicine, Tokyo, Japan
Int J Hematol 89:673-8. 2009..The 4-year overall survival rates by Kaplan-Meier analysis for Plk1-negative and positive patients were 80 and 38%, respectively (p = 0.02)...- Aggressive natural killer cell leukemia: therapeutic potential of L-asparaginase and allogeneic hematopoietic stem cell transplantationFumihiro Ishida
Department of Hematology, Shinshu University School of Medicine, Matsumoto, Japan
Cancer Sci 103:1079-83. 2012..33, 95% confidence interval; 0.13-0.83, P = 0.02). Early diagnosis of ANKL, l-asparaginase-based chemotherapy and allogeneic HSCT might lead to improved patient outcomes... - Clinical analysis of 52 patients with granular lymphocyte proliferative disorder (GLPD) showed frequent anemia in indolent T-cell GLPD in JapanShimpei Kawahara
Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
Eur J Haematol 82:308-14. 2009..The present analysis of 52 cases of GLPD in Japan showed that Japanese and Western cases of indolent T-GLPD clearly differ in their hematological complications... - Progressive respiratory distress in a patient with splenic marginal zone lymphomaAzuchi Masuda
Division of Hematology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
Intern Med 47:1281-2. 2008 - Expression levels of apoptosis-related proteins and Ki-67 in nasal NK / T-cell lymphomaHajime Yasuda
Division of Hematology, Department of Medicine, Juntendo University School of Medicine, Tokyo
Eur J Haematol 82:39-45. 2009..Nasal natural killer (NK)/T-cell lymphoma is characterized by chemo-resistance, angiodestruction, and aggressive tumor progression. Few studies exist on molecular characteristics of this disease entity... - Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disordersNorihiko Kawamata
Division of Hematology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
Eur J Haematol 74:424-9. 2005..These results suggested that inactivation of the cell cycle regulatory genes by DNA methylation could be associated with tumorigenesis in NK cell disorders, not only aggressive subtypes but also chronic subtype... - Changes in cell morphology and cytoskeletal organization are induced by human mitotic checkpoint gene, Bub1Jun Ando
Division of Haematology, Department of Internal Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, 113 8421 Tokyo, Japan
Biochem Biophys Res Commun 365:691-7. 2008..These observations suggest that Bub1 not only regulates the cell cycle, but also may be involved in the cytoskeletal control in interphase cells... - Chronic lymphocytic leukemia in a Japanese population: varied immunophenotypic profile, distinctive usage of frequently mutated IGH gene, and indolent clinical behaviorJunichi Tomomatsu
Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
Leuk Lymphoma 51:2230-9. 2010..Although Japanese cases of CLL showed heterogeneity in morphology and immunophenotype, most cases arose from post-antigen-selected B cells and presented with indolent clinical behavior... - Effective treatment of a refractory hairy cell leukemia variant with splenic pre-irradiation and alemtuzumabMakoto Sasaki
Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
Acta Haematol 119:48-53. 2008..This is the first report showing clinical effectiveness of splenic irradiation and alemtuzumab against refractory HCLv... - Selective apoptosis of natural killer-cell tumours by l-asparaginaseMiki Ando
Department of Haematology, Juntendo University School of Medicine, Tokyo, Japan
Br J Haematol 130:860-8. 2005..We confirmed rather specific anti-tumour activity of l-asparaginase against NK-cell tumours in vitro, which provides an experimental background to the clinical use of l-asparaginase for NK-cell tumours... - Neural cell adhesion molecule (CD56)-positive B-cell lymphomaYasushi Isobe
Department of Hematology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
Eur J Haematol 79:166-9. 2007..Although CD56 expression level varies among the cases, this molecule might play some roles in the manner of growth and expansion of CD56-positive B-cell lymphomas... - Epstein-Barr virus infection of human natural killer cell lines and peripheral blood natural killer cellsYasushi Isobe
Division of Hematology, Department of Medicine, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
Cancer Res 64:2167-74. 2004..We first report in vitro EBV infection of human NK cells and establishment of EBV-carrying NK clones, which should contribute to elucidate the role of EBV in the development of NK cell neoplasms... - Successful high-titer immunoglobulin therapy for persistent parvovirus B19 infection in a lymphoma patient treated with rituximab-combined chemotherapyYasushi Isobe
Division of Hematology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
Am J Hematol 77:370-3. 2004..We propose that the use of high-titer immunoglobulin against parvovirus B19 may enable such immunocompromised patients to eradicate the virus before sufficient immune system reconstruction... - Activity and safety of combination chemotherapy with methotrexate, ifosfamide, l-asparaginase and dexamethasone (MILD) for refractory lymphoid malignancies: a pilot studyYutaka Tsukune
Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
Eur J Haematol 84:310-5. 2010..MILD therapy was feasible and presented acceptable toxicity in patients with refractory or lethal lymphoid malignancies. The efficacy for T/NK-cell malignancies should be further evaluated... - Enteropathy-type T-cell lymphoma expressing NK-cell intraepithelial lymphocyte (NK-IEL) phenotypeNaoko Inagaki
Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
Leuk Lymphoma 45:1471-4. 2004..Because Southern blotting analysis showed a rearrangement of T-cell receptor (TCR) Cbeta in this case, the tumor is classified as an ETL. Based on the findings, NK-IELs may originate from T-cells, not NK-cells... - Pure red cell aplasia associated with expansion of CD3+ CD8+ granular lymphocytes expressing cytotoxicity against HLA-E+ cellsKiyoshi L Mori
Department of Haematology, Juntendo University School of Medicine, Tokyo, Japan
Br J Haematol 123:147-53. 2003..GLs of T-GLPD with PRCA have a potential positive activity against HLA-E+ cells, whereas GLs from T-GLPD without PRCA do not. CD94 may play a key role in the pathogenesis of PRCA in T-GLPD... - B-cell marker negative (CD7+, CD19-) Epstein-Barr virus-related pyothorax-associated lymphoma with rearrangement in the JH geneShigehisa Tomita
Department of Hematology, Juntendo University School of Medicine, 2-1-1, Hongo Bunkyo-ku, Tokyo, 113-8421 Japan
Leuk Lymphoma 44:727-30. 2003..Chromosomal abnormality of the lymphoma was complicated. It suggested that many transformations occurred. In the transformation process, probably B-cell antigens were lost, and T-cell antigens were aberrantly expressed... - Identification of Bcl-2/IgH fusion sequences using real-time PCR and chip-based microcapillary electrophoresisYoko Tabe
Department of Clinical Laboratory Medicine, Juntendo University School of Medicine, Tokyo, Japan
Clin Chem Lab Med 49:809-15. 2011..The determination of polymerase chain reaction (PCR) amplification product sizes of the Bcl-2/IgH fusion gene from follicular lymphoma (FL) provides evidence of clonal identity... - More than 13 years of hypereosinophila associated with clonal CD3-CD4+ lymphocytosis of TH2/TH0 typeKoichi Sugimoto
Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
Int J Hematol 75:281-4. 2002.... - Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3Atsushi Kato
Division of Hematology, Department of Internal Medicine and Division of Biochemical Analysis, Central Laboratory of Medical Sciences, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
J Biol Chem 277:28934-41. 2002..As Aup1 possesses domains related to signal transduction, these results suggest involvement of Aup1 in the integrin signaling... - Mononucleosis syndrome and acute monocytic leukemiaKenji Tamayose
Department of Hematolgy, Juntendo University School of Medicine, Tokyo, Japan
Eur J Haematol 68:236-8. 2002..Mononuclear leukocytes appearing during the mononucleosis syndrome were very similar to the initial leukemic cells. Varicella zoster virus mononucleosis syndrome was confirmed by delayed herpes zoster rash with dermatomal distribution... - Low-dose doxorubicin-induced necrosis in Jurkat cells and its acceleration and conversion to apoptosis by antioxidantsKoichi Sugimoto
Department of Haematology, Juntendo University School of Medicine, Tokyo, Japan
Br J Haematol 118:229-38. 2002..Some of the prenecrotic cells, therefore, might survive and obtain genomic instability. Antioxidants may be useful to suppress, at least to some extent, this vicious consequence... - A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute lymphoblastic leukemia involves the LIM homeodomain protein gene, Lhx4Norihiko Kawamata
Division of Hematology, Department of Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
Oncogene 21:4983-91. 2002..The Lhx4 gene is deregulated in the leukemic cells and Lhx4 protein may play an important role, possibly as an activator, in leukemogenesis... - CD3-negative, CD20-positive T-cell prolymphocytic leukemia: case report and review of the literatureKenji Tamayose
Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
Am J Hematol 71:331-5. 2002..Splenomegaly was a common feature. However, our case alone had "bright" CD20 expression on the leukemic cells. This is the first report of CD20(+) T-PLL... - Treatment of acute myeloid leukemia patients aged more than 75 years: results of the E-AML-01 trial of the Japanese Elderly Leukemia and Lymphoma Study Group (JELLSG)Mayumi Mori
Division of Hematology, Tokyo Metropolitan Geriatric Hospital, Sakaecho, Tokyo, Japan
Leuk Lymphoma 47:2062-9. 2006..0% and disease-free survival at 2 and 5 years was 21.0% and 11.2%, respectively. The therapy-related mortality rate at induction was 13.8%. BHAC-DM is feasible and effective for selected very elderly acute myeloid leukemia patients... - Improvement of idiopathic thrombocytopenic purpura by antithyroid therapyKoichi Sugimoto
Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
Eur J Haematol 74:73-4. 2005.... - [A clinical study of intraocular malignant lymphoma]Aki Ohta
Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
Nippon Ganka Gakkai Zasshi 110:588-93. 2006.... - Lymphomatoid gastropathy: a distinct clinicopathologic entity of self-limited pseudomalignant NK-cell proliferationKengo Takeuchi
The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
Blood 116:5631-7. 2010..However, LyGa is recognized as a pseudomalignant process because of its clinical characteristics. The concept of LyGa should be well recognized... - Extensive bone marrow necrosis and symptomatic hypercalcemia in B cell blastic transformation of chronic myeloid leukemia: report of a case and review of the literatureMasaaki Noguchi
Department of Hematology, Juntendo Urayasu Hospital, Urayasu shi, Chiba, Japan
Acta Haematol 118:111-6. 2007..As far as we know, this is the first case report of chronic myeloid leukemia concurrently developing bone marrow necrosis and hypercalcemia; this association was not reported in other types of leukemia or bone marrow malignancies... - Severe pulmonary complications in Japanese patients after bortezomib treatment for refractory multiple myelomaShigesaburo Miyakoshi
Department of Hematology, Toranomon Hospital, 2 2 2, Toranomon, Tokyo, Japan
Blood 107:3492-4. 2006..Our study suggests that bortezomib can cause serious lung injury, and that its incidence might vary among different ethnicities. Clinicians need to be alert to the possibility... - [Zygomycosis: two case reports and review of reported cases in the literature in Japan]Takeshi Mori
Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
Nippon Ishinkin Gakkai Zasshi 44:163-79. 2003..Five cases with allergic zygomycosis were all alive. There were only 14 cases in which isolated fungi were identified (Cunninghamella spp. from 5 cases, Mucor spp. from 2, Rhizomucor spp. from 2, and Rhizopus spp. from 5)... - Molecular analysis of oncogenes, ras family genes (N-ras, K-ras, H-ras), myc family genes (c-myc, N-myc) and mdm2 in natural killer cell neoplasmsKei-Ji Sugimoto
Division of Hematology, Department of Medicine, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan
Jpn J Cancer Res 93:1270-7. 2002..In contrast, overexpression of MDM2 might be associated with tumorigenesis of NK cell neoplasms, especially aggressive subclasses... - Ancient ubiquitous protein 1 and Syk link cytoplasmic tails of the integrin alpha(IIb)beta(3)Atsushi Kato
Division of Hematology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
Platelets 20:105-10. 2009.... - Clinical features of adult acute leukemia with 11q23 abnormalities in Japan: a co-operative multicenter studyHayato Tamai
Department of Hematology, Nippon Medical School, Sendagi 1 1 5, Bunkyo ku, Tokyo, Japan
Int J Hematol 87:195-202. 2008..However, further studies involving a large number of cases are required to assess the effect of allo-HSCT on adult AL with 11q23 abnormalities... - Intravascular large B-cell lymphomaKeiji J Sugimoto
Department of Hematology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
Am J Hematol 76:291-2. 2004 
Hepatocyte growth factor receptor is a coreceptor for adeno-associated virus type 2 infectionYuji Kashiwakura
Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan
J Virol 79:609-14. 2005..These data suggest that c-Met plays the role of coreceptor for AAV2 infection by facilitating AAV2 internalization into the cytoplasm...- Epstein-Barr virus-associated T-cell acute lymphoblastic leukaemiaSakura Sakajiri
Division of Hematology, Department of Medicine, Juntendo University School of Medicine, Hongo, Bunkyo-ku, Tokyo, Japan
Br J Haematol 117:127-9. 2002..The leukaemic cells, massively infiltrated into the liver and spleen, were resistant to chemotherapy. EBV might be associated with tumorigenesis of T-ALL, and characteristic clinical features of the patient... - NK cell lymphomaKazuo Oshimi
Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
Int J Hematol 76:118-21. 2002..These findings may change the treatment strategy. Finally, I will present the results on interim analysis of 166 cases of nasal-type NK-cell lymphoma collected in Japan between 1994 and 1998... - Late appearance of t(1;19)(q11;q11) in myelodysplastic syndrome associated with dysplastic eosinophilia and pulmonary alveolar proteinosisJun Ando
Department of Hematology, Juntendo University School of Medicine, Tokyo 113-8421, Japan
Cancer Genet Cytogenet 139:14-7. 2002..We postulate that this chromosomal rearrangement is involved in the development of eosinophilia and pulmonary alveolar proteinosis in MDS... - Multifocal motor neuropathy caused by a B-cell lymphoma producing a monoclonal IgM autoantibody against peripheral nerve myelin glycolipids GM1 and GD1bMasaaki Noguchi
Department of Haematology, Juntendo University School of Medicine, Tokyo, Japan
Br J Haematol 123:600-5. 2003..This antibody bound to glycolipids GM1 and GD1b in peripheral motor nerve myelin, presumably initiating formation of destructive immune complexes that caused multifocal motor neuropathy... - Epstein-Barr virus-positive Hodgkin's lymphoma in a patient with chronic active Epstein-Barr virus infectionKenji Tamayose
Int J Hematol 80:199-200. 2004 - CD20-positive extranodal NK-cell lymphoma, nasal-typeJun Ando
Eur J Haematol 80:549-50. 2008 - [Case of malignant lymphoma arising from the posterior mediastinum, with pleural effusion]Osamu Nagashima
Department of Respiratory Medicine, Juntendo University School of Medicine
Nihon Kokyuki Gakkai Zasshi 42:772-6. 2004..A diagnosis of diffuse large B cell lymphoma was made from the typical histological features. The patient was treated with combination chemotherapy (CHOP) and rituximab and improved dramatically... - T-gamma delta LGL leukemia with complicationsKazuo Oshimi
Intern Med 45:707-8. 2006 - Epstein-Barr virus (EBV)-encoded RNA promotes growth of EBV-infected T cells through interleukin-9 inductionLixin Yang
Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita ku, Sapporo 060 0815, Japan
Cancer Res 64:5332-7. 2004..Analysis of nasal lymphoma biopsies indicated that three of four specimens expressed IL-9. The present findings suggest that EBV directly affects the pathogenesis of EBV-associated T-cell diseases... - Retroviral expression screening of oncogenes in natural killer cell leukemiaYoung Lim Choi
Division of Functional Genomics, Jichi Medical School, 3311-1 Yakushiji, Kawachigun, Tochigi 329-0498, Japan
Leuk Res 29:943-9. 2005..Mutation-specific PCR analysis indicated that the KRAS mutation was present only in KHYG-1 cells, not in another ANKL cell line or in clinical specimens (n=8)... - Relationship between CD4(+)/CD8(+) T cell ratio and T cell activation in multiple myeloma: reference to IL-16Michiaki Koike
Department of Internal Medicine, Juntendo University Izu Nagaoka Hospital, 1129 Nagaoka, Izu Nagaoka, Tagata gun, Shizuoka, Japan
Leuk Res 26:705-11. 2002..001). The decrease of CD4(+) T cells in MM may be mediated by activation of CD8(+) T cells derived cytokine IL-16. In addition, these T cell phenotypic changes and the IL-16 level appear to be useful indicators of disease activity... - Nationwide survey of hemophagocytic lymphohistiocytosis in JapanEiichi Ishii
Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan
Int J Hematol 86:58-65. 2007..Although this nationwide survey establishes the heterogeneous characteristics of HLH, the results should be useful in planning prospective studies to identify the most effective therapy for each HLH subtype... - [Acyclovir combined with plasma exchange for disseminated varicella-zoster virus infection after bone marrow transplantation]Chunyong Lee
Department of Hematology, Juntendo University, Shizuoka Hospital
Rinsho Ketsueki 47:210-3. 2006..Acyclovir and plasma exchange rapidly controlled his VZV-related symptoms and signs. Disseminated VZV infection is often fatal, but acyclovir and plasma exchange may be useful for such infection by reducing the circulating viral load... - Lung injury associated with bortezomib therapy in relapsed/refractory multiple myeloma in Japan: a questionnaire-based report from the "lung injury by bortezomib" joint committee of the Japanese society of hematology and the Japanese society of Akihiko Gotoh
The Lung Injury by Bortezomib Joint Committee of the Japanese Society of Hematology and the Japanese Society of Clinical Hematology, Japan
Int J Hematol 84:406-12. 2006..Thus, future verification concerning this matter is warranted after the approval of bortezomib for use in Japan. Clinicians should be aware of the possibility of severe pulmonary complications associated with bortezomib therapy... - [The chimerism and GVT effects on murine mini-transplantation model]Takao Hirano
Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine
Nippon Rinsho 61:1527-34. 2003..The GVT effects were observed in both groups. However, GVT effects on G4 is stronger than that on G2 in pathological findings and serum IgE level... - [Clinical aspect of lymphatic tumors]Kazuo Oshimi
Nippon Naika Gakkai Zasshi 92:1838-41. 2003 - [Lung injury associated with bortezomib therapy in relapsed/refractory multiple myeloma in Japan: a questionnaire-based report from the "Lung Injury by Bortezomib" Joint Committee of the Japanese Society of Hematology and the Japanese Society ofAkihiko Gotoh
Rinsho Ketsueki 47:1521-7. 2006..84, p406-412, 2006) by permission of both the editorials of the Japanese Society of Hematology and the Japanese Society of Clinical Hematology, and should be considered as the Japanese translation of the article... - Cytokine-producing sarcoma mimics eosinophilic leukaemiaJun Ando
Eur J Haematol 78:169-70. 2007 - Rapid elimination of circulating leukemia cells with a small dose of alemtuzumab in refractory aggressive NK-cell leukemiaMakoto Sasaki
Eur J Haematol 78:545. 2007 - [Treatment of chronic lymphocytic leukemia and NK-cell leukemia/lymphoma]Koichi Sugimoto
Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine
Nippon Rinsho 65:569-74. 2007 - Allogeneic haematopoietic stem cell transplantation as a promising treatment for natural killer-cell neoplasmsNaoko Murashige
Haematopoietic Stem Cell Transplantation Unit, the National Cancer Centre Hospital and Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Japan
Br J Haematol 130:561-7. 2005..03), age (>or=40 years vs. <40 years; relative risk 2.85), and diagnoses (extranodal NK/T-cell lymphoma versus others; relative risk 3.94) significantly affected PFS. Allo-HSCT is a promising treatment for NK-cell neoplasms... - Combination brings long-term remission in acute promyelocytic leukemia refractory for both all-trans retinoic acid and arsenic trioxideMakoto Sasaki
Eur J Haematol 81:160. 2008 - Phase I study of dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide (SMILE) chemotherapy for advanced-stage, relapsed or refractory extranodal natural killer (NK)/T-cell lymphoma and leukemiaMotoko Yamaguchi
Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
Cancer Sci 99:1016-20. 2008..Although its safety and efficacy require further evaluation, we recommend a SMILE chemotherapy dose level of 1 for further clinical studies... - A multicenter analysis of the FIP1L1-alphaPDGFR fusion gene in Japanese idiopathic hypereosinophilic syndrome: an aberrant splicing skipping the alphaPDGFR exon 12Akiko Sada
Hematology Oncology, Department of Medicine, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
Ann Hematol 86:855-63. 2007..Considering the relatively low incidence of the FIP1L1-alphaPDGFR transcript positive case, extreme care must therefore be taken when making a diagnosis using RT-PCR before imatinib therapy... - Mxi1 isoforms are expressed in hematological cell lines and normal bone marrowNorihiko Kawamata
Division of Hematology Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
Int J Oncol 26:1369-75. 2005.... - Blastic natural killer cell lymphoma/leukemia (CD56-positive blastic tumor): prognostication and categorization according to anatomic sites of involvementRitsuro Suzuki
Division of Molecular Medicine, Aichi Cancer Center, Nagoya, Japan
Cancer 104:1022-31. 2005..Although further investigations are needed to settle a marker for distinction, the presence of cutaneous involvement is a useful prognostic factor...