Kei Ohnuma


Affiliation: Juntendo University School of Medicine
Country: Japan


  1. Itoh T, Hatano R, Komiya E, Otsuka H, Narita Y, Aune T, et al. Biological effects of IL-26 on T cell-mediated skin inflammation including psoriasis. J Invest Dermatol. 2018;: pubmed publisher
    ..Altogether, our data indicate that IL-26 may be a promising therapeutic target in T cell-mediated skin inflammation including psoriasis. ..
  2. Okamoto T, Yamazaki H, Hatano R, Yamada T, Kaneko Y, Xu C, et al. Targeting CD26 suppresses proliferation of malignant mesothelioma cell via downmodulation of ubiquitin-specific protease 22. Biochem Biophys Res Commun. 2018;504:491-498 pubmed publisher
    ..By demonstrating a CD26-related linkage with USP22 in MPM cell inhibition induced by HuCD26mAb, our present study hence characterizes USP22 as a novel target molecule while concurrently suggesting a new therapeutic strategy for MPM. ..
  3. Komiya E, Ohnuma K, Yamazaki H, Hatano R, Iwata S, Okamoto T, et al. CD26-mediated regulation of periostin expression contributes to migration and invasion of malignant pleural mesothelioma cells. Biochem Biophys Res Commun. 2014;447:609-15 pubmed publisher
    ..While providing new and profound insights into the molecular mechanisms involved in MPM biology, these findings may also lead to the development of novel therapeutic strategies for MPM. ..
  4. request reprint
    Ohnuma K, Hatano R, Komiya E, Otsuka H, Itoh T, Iwao N, et al. A novel role for CD26/dipeptidyl peptidase IV as a therapeutic target. Front Biosci (Landmark Ed). 2018;23:1754-1779 pubmed
  5. Nomura S, Iwata S, Hatano R, Komiya E, Dang N, Iwao N, et al. Inhibition of VEGF-dependent angiogenesis by the anti-CD82 monoclonal antibody 4F9 through regulation of lipid raft microdomains. Biochem Biophys Res Commun. 2016;474:111-117 pubmed publisher
    ..Our present work therefore suggests that CD82 on EC is a potential target for anti-angiogenic therapy in VEGFR2-dependent tumor angiogenesis. ..
  6. Katayose T, Iwata S, Oyaizu N, Hosono O, Yamada T, Dang N, et al. The role of Cas-L/NEDD9 as a regulator of collagen-induced arthritis in a murine model. Biochem Biophys Res Commun. 2015;460:1069-75 pubmed publisher
    ..Our results strongly suggest that Cas-L/NEDD9 plays a pivotal role in the pathophysiology of CIA, and that Cas-L/NEDD9 may be a potential molecular target for the treatment of RA. ..
  7. Komiya E, Hatano R, Otsuka H, Itoh T, Yamazaki H, Yamada T, et al. A possible role for CD26/DPPIV enzyme activity in the regulation of psoriatic pruritus. J Dermatol Sci. 2017;86:212-221 pubmed publisher
    ..On the other hand, scratching induced by imiquimod was increased in DPPIV overexpressing-mice. These results suggest that inhibition of DPPIV enzyme activity regulates pruritus in PSO. ..