Francois Niyonsaba

Summary

Affiliation: Juntendo University School of Medicine
Country: Japan

Publications

  1. doi request reprint The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions
    Francois Niyonsaba
    Atopy Alergy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Leukoc Biol 94:159-70. 2013
  2. doi request reprint Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells
    Francois Niyonsaba
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 184:3526-34. 2010
  3. ncbi request reprint Multifunctional antimicrobial proteins and peptides: natural activators of immune systems
    Francois Niyonsaba
    Atopy Allergy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Curr Pharm Des 15:2393-413. 2009
  4. doi request reprint The human antimicrobial peptide dermcidin activates normal human keratinocytes
    F Niyonsaba
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    Br J Dermatol 160:243-9. 2009
  5. pmc Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines
    Gyi Aung
    Atopy Allergy Research Centre, Juntendo University School of Medicine, Tokyo, Japan
    Immunology 132:527-39. 2011
  6. pmc Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation
    Yan Zheng
    Department of Dermatology, Atopy Allergy Research Centre, Juntendo University School of Medicine, Tokyo, Japan
    Immunology 124:357-67. 2008
  7. pmc Human beta-defensin-2 functions as a chemotactic agent for tumour necrosis factor-alpha-treated human neutrophils
    Francois Niyonsaba
    Department of Host Defense and Biochemical Research, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Immunology 111:273-81. 2004
  8. ncbi request reprint Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines
    Francois Niyonsaba
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Invest Dermatol 127:594-604. 2007
  9. doi request reprint Lipid-soluble components of honeybee-collected pollen exert antiallergic effect by inhibiting IgE-mediated mast cell activation in vivo
    Yasuko Ishikawa
    Atopy Allergy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Phytother Res 23:1581-6. 2009
  10. pmc A cathelicidin family of human antibacterial peptide LL-37 induces mast cell chemotaxis
    Francois Niyonsaba
    Department of Biochemistry, Juntendo University, School of Medicine, Tokyo, Japan
    Immunology 106:20-6. 2002

Collaborators

Detail Information

Publications33

  1. doi request reprint The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions
    Francois Niyonsaba
    Atopy Alergy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Leukoc Biol 94:159-70. 2013
    ..The results described here may aid in the development of IDRs as novel, anti-infective and immunomodulatory agents...
  2. doi request reprint Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells
    Francois Niyonsaba
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 184:3526-34. 2010
    ....
  3. ncbi request reprint Multifunctional antimicrobial proteins and peptides: natural activators of immune systems
    Francois Niyonsaba
    Atopy Allergy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Curr Pharm Des 15:2393-413. 2009
    ..Here, we briefly outline the structure, regulation of expression, and multifunctional roles of principal skin-derived AMPs...
  4. doi request reprint The human antimicrobial peptide dermcidin activates normal human keratinocytes
    F Niyonsaba
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    Br J Dermatol 160:243-9. 2009
    ..Recently, the DCD peptides DCD-1 and DCD-1L have been shown to display in vitro microbicidal activities against bacteria and viruses...
  5. pmc Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines
    Gyi Aung
    Atopy Allergy Research Centre, Juntendo University School of Medicine, Tokyo, Japan
    Immunology 132:527-39. 2011
    ....
  6. pmc Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation
    Yan Zheng
    Department of Dermatology, Atopy Allergy Research Centre, Juntendo University School of Medicine, Tokyo, Japan
    Immunology 124:357-67. 2008
    ..Besides its antimicrobial properties, therefore, psoriasin may contribute to innate immunity through enhancing neutrophil host defence functions at sites of inflammation or infection...
  7. pmc Human beta-defensin-2 functions as a chemotactic agent for tumour necrosis factor-alpha-treated human neutrophils
    Francois Niyonsaba
    Department of Host Defense and Biochemical Research, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Immunology 111:273-81. 2004
    ..This also suggests an important link between epithelial cell-derived antibacterial peptides and neutrophils during infection or inflammation...
  8. ncbi request reprint Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines
    Francois Niyonsaba
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Invest Dermatol 127:594-604. 2007
    ....
  9. doi request reprint Lipid-soluble components of honeybee-collected pollen exert antiallergic effect by inhibiting IgE-mediated mast cell activation in vivo
    Yasuko Ishikawa
    Atopy Allergy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Phytother Res 23:1581-6. 2009
    ..These results first reveal that lipid-soluble components of BP exert an antiallergic action by inhibiting the FcåRI-mediated cutaneous mast cell activation...
  10. pmc A cathelicidin family of human antibacterial peptide LL-37 induces mast cell chemotaxis
    Francois Niyonsaba
    Department of Biochemistry, Juntendo University, School of Medicine, Tokyo, Japan
    Immunology 106:20-6. 2002
    ..These results show that besides its antibacterial activities, LL-37 may have the potential to recruit mast cells to inflammation foci...
  11. ncbi request reprint Synergistic effect of antibacterial agents human beta-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli
    Xuejun Chen
    Department of Dermatology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Dermatol Sci 40:123-32. 2005
    ....
  12. doi request reprint Synergistic augmentation of inflammatory cytokine productions from murine mast cells by monomeric IgE and toll-like receptor ligands
    Hiroshi Takenaka
    Atopy Allergy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 391:471-6. 2010
    ....
  13. ncbi request reprint Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability
    Xuejun Chen
    Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan
    Eur J Immunol 37:434-44. 2007
    ..Together, these findings suggest the key role of hBD in inflammatory responses by recruiting and activating mast cells, and increasing vascular permeability...
  14. pmc GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils: opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression
    Yosuke Baba
    Atopy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Biol Chem 287:32689-96. 2012
    ..These results indicate that GATA2 and GATA1 positively and negatively control human ST2 gene transcription, respectively...
  15. ncbi request reprint The extra domain A of fibronectin stimulates murine mast cells via toll-like receptor 4
    Srie Prihianti Gondokaryono
    Atopy Allergy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    J Leukoc Biol 82:657-65. 2007
    ..Altogether, these results suggest that the TLR4-mediated activation of mast cells by endogenous ligand FN-EDA might contribute to the pathogenesis of RA through proinflammatory cytokine production...
  16. ncbi request reprint Monomeric IgE and lipopolysaccharide synergistically prevent mast-cell apoptosis
    Sumanasiri T M Jayawardana
    Atopy Allergy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 365:137-42. 2008
    ..Altogether, these results suggest that LPS, in a TLR4-dependent manner, together with IgE, synergistically prevent mast-cell apoptosis and may contribute to regulate the tissue mast-cell number...
  17. doi request reprint Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes
    Md Imranul Hoq
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Dermatol Sci 64:108-18. 2011
    ..Human catestatin exhibits three single nucleotide polymorphisms: Gly364Ser, Pro370Leu, and Arg374Gln...
  18. ncbi request reprint The human beta-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 and ERK MAPK activation in primary human keratinocytes
    Francois Niyonsaba
    Atopy Allergy Research Center, Juntendo University School of Medicine, Hongo, Tokyo, Japan
    J Immunol 175:1776-84. 2005
    ..Thus, the ability of hBDs and LL-37 to induce IL-18 secretion by keratinocytes provides a new mechanism for these peptides in innate immunity and an understanding of their role in the pathogenesis of skin disorders...
  19. doi request reprint Inhibitory effect of honeybee-collected pollen on mast cell degranulation in vivo and in vitro
    Yasuko Ishikawa
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Med Food 11:14-20. 2008
    ....
  20. doi request reprint Expression and functional characterization of retinoic acid-inducible gene-I-like receptors of mast cells in response to viral infection
    Minoru Fukuda
    Department of Infection Control Science, Juntendo University School of Medicine, Tokyo, Japan
    J Innate Immun 5:163-73. 2013
    ..These data provide additional novel information that improves our understanding of antiviral innate responses that involve mast cells...
  21. doi request reprint Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes
    Xue Chen
    Atopy Allergy Research Center, Juntendo University Graduate School of Medicine, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 433:532-7. 2013
    ....
  22. ncbi request reprint Epithelial cell-derived antibacterial peptides human beta-defensins and cathelicidin: multifunctional activities on mast cells
    Francois Niyonsaba
    Department of Biochemistry, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Curr Drug Targets Inflamm Allergy 2:224-31. 2003
    ....
  23. doi request reprint Evaluation of the effect of human beta-defensins on neutrophil apoptosis
    Isao Nagaoka
    Department of Host Defense and Biochemical Research, Juntendo University School of Medicine, Tokyo, Japan
    Int Immunol 20:543-53. 2008
    ..Suppression of neutrophil apoptosis results in the prolongation of their lifespan and may be advantageous for the host defense against bacterial invasion...
  24. ncbi request reprint Human defensins and cathelicidins in the skin: beyond direct antimicrobial properties
    Francois Niyonsaba
    Atopy Allergy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Crit Rev Immunol 26:545-76. 2006
    ..Moreover, we discuss the roles of these peptides in skin diseases and highlight their possible use in near therapeutic development...
  25. ncbi request reprint Evaluation of the effect of α-defensin human neutrophil peptides on neutrophil apoptosis
    Isao Nagaoka
    Department of Host Defense and Biochemical Research, Graduate School of Medicine, Juntendo University, Bunkyo ku, Tokyo, Japan
    Int J Mol Med 26:925-34. 2010
    ..The suppression of neutrophil apoptosis results in the prolongation of their lifespan and could be advantageous for the host defense against bacterial invasion...
  26. ncbi request reprint Upregulation of the release of granulocyte-macrophage colony-stimulating factor from keratinocytes stimulated with cysteine protease activity of recombinant major mite allergens, Der f 1 and Der p 1
    Takasuke Ogawa
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 146:27-35. 2008
    ....
  27. doi request reprint Involvement of PU.1 in mast cell/basophil-specific function of the human IL1RL1/ST2 promoter
    Yosuke Baba
    Atopy Allergy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Allergol Int 61:461-7. 2012
    ..In the present study, we analyzed regulation mechanism of the human ST2 promoter in the human mast cell line LAD2 and basophilic cell line KU812...
  28. ncbi request reprint Protective roles of the skin against infection: implication of naturally occurring human antimicrobial agents beta-defensins, cathelicidin LL-37 and lysozyme
    Francois Niyonsaba
    Atopy Allergy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Dermatol Sci 40:157-68. 2005
    ..Understanding the actions of antimicrobial agents in skin will provide further insight into the mechanism of innate cutaneous disease control, and yield novel therapeutic approaches to the treatment of skin disorders...
  29. pmc Augmentation of the lipopolysaccharide-neutralizing activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by replacement with hydrophobic and cationic amino acid residues
    Isao Nagaoka
    Department of Biochemistry, Juntendo University School of Medicine, Tokyo, Japan
    Clin Diagn Lab Immunol 9:972-82. 2002
    ....
  30. pmc Modulation of neutrophil apoptosis by antimicrobial peptides
    Isao Nagaoka
    Department of Host Defense and Biochemical Research, Juntendo University, Graduate School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    ISRN Microbiol 2012:345791. 2012
    ..Suppression of neutrophil apoptosis results in the prolongation of their lifespan and may be advantageous for the host defense against bacterial invasion...
  31. ncbi request reprint Epithelial cell-derived human beta-defensin-2 acts as a chemotaxin for mast cells through a pertussis toxin-sensitive and phospholipase C-dependent pathway
    Francois Niyonsaba
    Department of Biochemistry, School of Medicine, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Int Immunol 14:421-6. 2002
    ..Thus, we suggest that hBD-2, which was originally believed to be involved in innate host defense, may participate in the recruitment of mast cells to inflammation foci...
  32. ncbi request reprint Comparison of human tonsillar mast cell localization and ultrastructural observations between IgE-mediated allergic and nonallergic donors
    Hidenori Yokoi
    Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo, Japan
    Allergy Asthma Proc 27:415-21. 2006
    ..Taken together, these findings suggest that tonsillar MCs distribute differently in allergic and nonallergic donors, and that MCs in the interfollicular area might be activated by direct contact with CD4+ T cells...
  33. doi request reprint Crucial role for autophagy in degranulation of mast cells
    Hiroko Ushio
    Atopy Allergy Research Center, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    J Allergy Clin Immunol 127:1267-76.e6. 2011
    ..However, a role for autophagy in development and/or function of mast cells is unknown...