Takashi Murayama

Summary

Affiliation: Juntendo University School of Medicine
Country: Japan

Publications

  1. pmc Postulated role of interdomain interaction between regions 1 and 2 within type 1 ryanodine receptor in the pathogenesis of porcine malignant hyperthermia
    Takashi Murayama
    Department of Pharmacology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Biochem J 402:349-57. 2007
  2. ncbi request reprint Postulated role of interdomain interactions within the type 1 ryanodine receptor in the low gain of Ca2+-induced Ca2+ release activity of mammalian skeletal muscle sarcoplasmic reticulum
    Takashi Murayama
    Department of Pharmacology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Am J Physiol Cell Physiol 288:C1222-30. 2005
  3. ncbi request reprint RyR1 exhibits lower gain of CICR activity than RyR3 in the SR: evidence for selective stabilization of RyR1 channel
    Takashi Murayama
    Department of Pharmacology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Am J Physiol Cell Physiol 287:C36-45. 2004
  4. ncbi request reprint Roles of two ryanodine receptor isoforms coexisting in skeletal muscle
    Takashi Murayama
    Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan
    Trends Cardiovasc Med 12:305-11. 2002
  5. pmc Usefulness of running wheel for detection of congestive heart failure in dilated cardiomyopathy mouse model
    Masami Sugihara
    Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    PLoS ONE 8:e55514. 2013
  6. ncbi request reprint Ryanodine receptor isoforms of non-Mammalian skeletal muscle
    Yasuo Ogawa
    Department of Pharmacology, Juntendo University, Tokyo, Japan
    Front Biosci 7:d1184-94. 2002
  7. pmc Frog alpha- and beta-ryanodine receptors provide distinct intracellular Ca2+ signals in a myogenic cell line
    Taku Kashiyama
    Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan
    PLoS ONE 5:e11526. 2010
  8. pmc Role of amino-terminal half of the S4-S5 linker in type 1 ryanodine receptor (RyR1) channel gating
    Takashi Murayama
    Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, Tokyo 113 8421, Japan
    J Biol Chem 286:35571-7. 2011
  9. ncbi request reprint Changes in Ca2+ handling in adult MG29-deficient skeletal muscle
    Nagomi Kurebayashi
    Department of Pharmacology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 310:1266-72. 2003
  10. pmc Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function
    Sho Kakizawa
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    EMBO J 31:417-28. 2012

Collaborators

Detail Information

Publications26

  1. pmc Postulated role of interdomain interaction between regions 1 and 2 within type 1 ryanodine receptor in the pathogenesis of porcine malignant hyperthermia
    Takashi Murayama
    Department of Pharmacology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Biochem J 402:349-57. 2007
    ..These results suggest that stimulation of the RyR1MHS channel caused by affected inter-domain interaction between regions 1 and 2 is an underlying mechanism for dysfunction of Ca2+ homoeostasis seen in the MH phenotype...
  2. ncbi request reprint Postulated role of interdomain interactions within the type 1 ryanodine receptor in the low gain of Ca2+-induced Ca2+ release activity of mammalian skeletal muscle sarcoplasmic reticulum
    Takashi Murayama
    Department of Pharmacology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Am J Physiol Cell Physiol 288:C1222-30. 2005
    ..These findings suggest that the low CICR gain of RyR1 is important in normal Ca(2+) handling in skeletal muscle and that perturbation of this state may result in muscle diseases such as malignant hyperthermia...
  3. ncbi request reprint RyR1 exhibits lower gain of CICR activity than RyR3 in the SR: evidence for selective stabilization of RyR1 channel
    Takashi Murayama
    Department of Pharmacology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Am J Physiol Cell Physiol 287:C36-45. 2004
    ....
  4. ncbi request reprint Roles of two ryanodine receptor isoforms coexisting in skeletal muscle
    Takashi Murayama
    Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan
    Trends Cardiovasc Med 12:305-11. 2002
    ..This short review describes the biological meanings of this selective suppression and discusses physiological roles and significance of the two RyR isoforms in vertebrate skeletal muscle...
  5. pmc Usefulness of running wheel for detection of congestive heart failure in dilated cardiomyopathy mouse model
    Masami Sugihara
    Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    PLoS ONE 8:e55514. 2013
    ..We aimed to diagnose CHF in live DCM model mice by measuring voluntary exercise using a running wheel and to determine causes of death in these mice...
  6. ncbi request reprint Ryanodine receptor isoforms of non-Mammalian skeletal muscle
    Yasuo Ogawa
    Department of Pharmacology, Juntendo University, Tokyo, Japan
    Front Biosci 7:d1184-94. 2002
    ..Taking these findings into consideration, we conclude that CICR is too slow to explain the physiological Ca2+ release on depolarization...
  7. pmc Frog alpha- and beta-ryanodine receptors provide distinct intracellular Ca2+ signals in a myogenic cell line
    Taku Kashiyama
    Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan
    PLoS ONE 5:e11526. 2010
    ..However, the roles and significance of the two isoforms in excitation-contraction (E-C) coupling remains to be elucidated...
  8. pmc Role of amino-terminal half of the S4-S5 linker in type 1 ryanodine receptor (RyR1) channel gating
    Takashi Murayama
    Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, Tokyo 113 8421, Japan
    J Biol Chem 286:35571-7. 2011
    ..These results suggest that N-terminal half of the S4-S5 linker may form an α-helical structure and play an important role in RyR1 channel gating...
  9. ncbi request reprint Changes in Ca2+ handling in adult MG29-deficient skeletal muscle
    Nagomi Kurebayashi
    Department of Pharmacology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 310:1266-72. 2003
    ..Thus MG29 is not involved in the SOC activation at variance with the previous conclusion with immature muscles...
  10. pmc Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function
    Sho Kakizawa
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    EMBO J 31:417-28. 2012
    ..These findings suggest that NICR via RyR1 plays a regulatory role in the physiological and pathophysiological functions of the brain...
  11. pmc Cell cycle-dependent microtubule-based dynamic transport of cytoplasmic dynein in mammalian cells
    Takuya Kobayashi
    Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan
    PLoS ONE 4:e7827. 2009
    ..However, regulatory mechanism of the cell-cycle dependent distribution of dynein has not fully been understood...
  12. doi request reprint Two ryanodine receptor isoforms in nonmammalian vertebrate skeletal muscle: possible roles in excitation-contraction coupling and other processes
    Takashi Murayama
    Department of Pharmacology, Juntendo University School of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo, Japan
    Prog Biophys Mol Biol 105:134-44. 2011
    ..We will discuss possible roles and significance of the two RyR isoforms in E-C coupling and other processes in nonmammalian vertebrate skeletal muscle...
  13. pmc Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy
    Takeshi Suzuki
    Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, Bunkyo ku, Tokyo, Japan
    PLoS ONE 7:e35353. 2012
    ..In order to address this issue, properties of the myocardium and underlying gene expressions were studied using a knock-in mouse model of human inherited DCM caused by a deletion mutation ΔK210 in cardiac troponinT...
  14. ncbi request reprint Subcellular distribution of ryanodine receptors in the cardiac muscle of carp (Cyprinus carpio)
    Akihito Chugun
    Dept of Pharmacology, School of Medicine, Juntendo Univ, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
    Am J Physiol Regul Integr Comp Physiol 285:R601-9. 2003
    ..Electron microscopic images of the carp myocardium showed that the SR was observed largely as the subsarcolemmal cisternae and the reticular SR, suggesting that the RyR is localized in the junctional and corbular SR...
  15. pmc Engineering a novel multifunctional green fluorescent protein tag for a wide variety of protein research
    Takuya Kobayashi
    Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan
    PLoS ONE 3:e3822. 2008
    ..One of the major problems concerning the protein tagging is that many constructs with different tags have to be made for different applications, which is time- and resource-consuming...
  16. ncbi request reprint Molecular cloning and characterization of ryanodine receptor from unfertilized sea urchin eggs
    Mieko Shiwa
    Department of Pharmacology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Am J Physiol Regul Integr Comp Physiol 282:R727-37. 2002
    ..These results suggest that suRyR may be expressed as a functional Ca(2+)-induced Ca(2+) release channel, which might also be involved in cADPR-induced Ca(2+) release...
  17. ncbi request reprint Cellular redox state protects acetaldehyde-induced alteration in cardiomyocyte function by modifying Ca2+ release from sarcoplasmic reticulum
    Toshiharu Oba
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Am J Physiol Heart Circ Physiol 294:H121-33. 2008
    ..The present results suggest that acetaldehyde acts as an RyR2 activator to disturb cardiac muscle function, and redox potential protects the heart from acetaldehyde-induced alterations in myocytes...
  18. ncbi request reprint Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors)
    Bailong Xiao
    Cardiovascular Research Group, Department of Physiology and Biophysics, University of Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 277:41778-85. 2002
    ..These observations demonstrate that RyR2 is capable of forming functional heteromeric channels with RyR3 and RyR1, whereas RyR1 is incapable of forming heteromeric channels with RyR3...
  19. ncbi request reprint Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development
    Daniela Rossi
    Molecular Medicine Section, Department of Neuroscience, Interuniversitary Institute of Myology, University of Siena, Siena, Italy
    Cell Calcium 41:573-80. 2007
    ..The activity of recombinant RyR1 but not RyR3 channels was found to be inhibited in native conditions, suggesting that this property may not be dependent on a muscle environment...
  20. ncbi request reprint Redox states of type 1 ryanodine receptor alter Ca(2+) release channel response to modulators
    Toshiharu Oba
    Department of Physiology, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    Am J Physiol Cell Physiol 282:C684-92. 2002
    ..These results suggest that redox states of critical sulfhydryls located on the cytoplasmic side of the RyR1 may alter both gating properties of the channel and responsiveness to channel modulators...
  21. pmc Malignant hyperthermia mutation sites in the Leu2442-Pro2477 (DP4) region of RyR1 (ryanodine receptor 1) are clustered in a structurally and functionally definable area
    Mark L Bannister
    Boston Biomedical Research Institute, Watertown, MA 02472, USA
    Biochem J 401:333-9. 2007
    ..The data in the present paper indicates that mutation of residues in this region disrupts the interdomain interactions that stabilize the closed state of the channel...
  22. ncbi request reprint Type-3 ryanodine receptor involved in Ca2+-induced Ca2+ release and transmitter exocytosis at frog motor nerve terminals
    Masakazu Kubota
    Department of Physiology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cell Calcium 38:557-67. 2005
    ....
  23. ncbi request reprint The dyf-3 gene encodes a novel protein required for sensory cilium formation in Caenorhabditis elegans
    Takashi Murayama
    Department of Biology, Faculty of Sciences, Kyushu University Graduate School, 6 10 1, Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Mol Biol 346:677-87. 2005
    ..Reduction of dyf-3Colon, two colonsgfp expression in a daf-19 mutant suggests that dyf-3 expression is regulated by DAF-19 transcription factor, and DYF-3 may be involved in the intraflagellar transport system...
  24. ncbi request reprint Synthesis of cyclic ADP-carbocylcic-xylose and its 3"-O-methyl analogue as stable and potent Ca2+ -mobilizing agents
    Takashi Kudoh
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo, Japan
    Nucleosides Nucleotides Nucleic Acids 25:583-99. 2006
    ..From these results, we newly designed another 3"-modified analogues of cADPcR and identified the N1-"xylo"-type carbocyclic analogue, i.e., cADPcX (4), as one of the most potent cADPR-related compounds reported so far...
  25. doi request reprint Synthesis of 5''-branched derivatives of cyclic ADP-carbocyclic-ribose, a potent Ca2+-mobilizing agent: The first antagonists modified at the N1-ribose moiety
    Natsumi Sakaguchi
    Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    Bioorg Med Chem Lett 18:3814-8. 2008
    ..These target compounds were identified as the first antagonists of cADPR without a substituent at the adenine 8-position, and were shown to be stable due to the N1-carbocyclic-ribosyl structure...
  26. ncbi request reprint Substitution at the 8-position of 3''-deoxy-cyclic ADP-carbocyclic-ribose, a highly potent Ca2+-mobilizing agent, provides partial agonists
    Takashi Kudoh
    Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    Bioorg Med Chem 15:3032-40. 2007
    ..Among these compounds, 8-NH(2)-3''-deoxy-cADPcR (10) was identified as a potent partial agonist with an EC(50) value of 17 nM...