Okio Hino

Summary

Affiliation: Juntendo University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Diagnostic biomarker of asbestos-related mesothelioma: example of translational research
    Hino Okio
    Department of Pathology and Oncology, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo, Japan
    Cancer Sci 98:1147-51. 2007
  2. ncbi request reprint Studies of familial tumors using models: genotype, phenotype, and dramatype in carcinogenesis
    Okio Hino
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Int J Clin Oncol 9:257-61. 2004
  3. ncbi request reprint Multistep renal carcinogenesis in the Eker (Tsc 2 gene mutant) rat model
    Okio Hino
    Department of Pathology, Juntendo University School of Medicine 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Curr Mol Med 4:807-11. 2004
  4. ncbi request reprint Intentional delay of human hepatocarcinogenesis due to suppression of chronic hepatitis
    Okio Hino
    Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
    Intervirology 48:6-9. 2005
  5. ncbi request reprint 'On environmental carcinogens: from an era of risk evaluation to an era of risk management' Tokyo, Japan, 29 july 2006
    Okio Hino
    Department of Pathology and Oncology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyou ku, Tokyo, 113 8421, Japan
    Cancer Sci 98:617-9. 2007
  6. pmc Diagnostic tumor marker of asbestos-related mesothelioma
    Okio Hino
    Department of Pathology and Oncology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Environ Health Prev Med 13:71-4. 2008
  7. doi request reprint Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter
    Ke Tan
    Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Hum Pathol 41:1330-8. 2010
  8. doi request reprint Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dubé gene product
    Lu Wang
    Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo, Japan
    FEBS Lett 584:39-43. 2010
  9. ncbi request reprint Gene expression profile of DNA binding protein A transgenic mice
    Hiroshi Tobita
    Department of Pathology, Juntendo University School of Medicine, Hongo, Tokyo 113 8421, Japan
    Int J Oncol 29:673-9. 2006
  10. ncbi request reprint Transcription of dbpA, a Y box binding protein, is positively regulated by E2F1: implications in hepatocarcinogenesis
    Yasuo Arakawa
    Department of Experimental Pathology, Cancer Institute, Japanese Fundation of Cancer Research, Tokyo, Japan
    Biochem Biophys Res Commun 322:297-302. 2004

Detail Information

Publications83

  1. ncbi request reprint Diagnostic biomarker of asbestos-related mesothelioma: example of translational research
    Hino Okio
    Department of Pathology and Oncology, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo, Japan
    Cancer Sci 98:1147-51. 2007
    ..Asbestos-related mesothelioma should be ascribed as a typical environmental carcinogen. In this review, we will present asbestos-related mesothelioma for the study of problems in environmental carcinogenesis...
  2. ncbi request reprint Studies of familial tumors using models: genotype, phenotype, and dramatype in carcinogenesis
    Okio Hino
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Int J Clin Oncol 9:257-61. 2004
  3. ncbi request reprint Multistep renal carcinogenesis in the Eker (Tsc 2 gene mutant) rat model
    Okio Hino
    Department of Pathology, Juntendo University School of Medicine 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Curr Mol Med 4:807-11. 2004
    ..I will review this unique model for the study of multistep renal carcinogenesis and discuss cancer prevention and delay of carcinogenesis...
  4. ncbi request reprint Intentional delay of human hepatocarcinogenesis due to suppression of chronic hepatitis
    Okio Hino
    Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
    Intervirology 48:6-9. 2005
    ..These conditions may be designated as the 'hypercarcinogenic state'. Our goal is to lead the 'hypercarcinogenic state' to the 'normo- or hypocarcinogenic' state and to prevent HCC development (intentional delay of HCC)...
  5. ncbi request reprint 'On environmental carcinogens: from an era of risk evaluation to an era of risk management' Tokyo, Japan, 29 july 2006
    Okio Hino
    Department of Pathology and Oncology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyou ku, Tokyo, 113 8421, Japan
    Cancer Sci 98:617-9. 2007
  6. pmc Diagnostic tumor marker of asbestos-related mesothelioma
    Okio Hino
    Department of Pathology and Oncology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Environ Health Prev Med 13:71-4. 2008
    ..We developed a novel ELISA system (N-ERC/mesothelin). Recently, we found that N-ERC/mesothelin was a potentially useful diagnostic marker for asbestos-related mesothelioma...
  7. doi request reprint Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter
    Ke Tan
    Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Hum Pathol 41:1330-8. 2010
    ..We also identified 4 CpG sites, among the 20 sites studied, to be more specifically hypomethylated in MM cases...
  8. doi request reprint Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dubé gene product
    Lu Wang
    Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo, Japan
    FEBS Lett 584:39-43. 2010
    ..A phospho-mimic mutation at Ser62 enhanced the formation of the FLCN-AMPK complex. These results suggest that function(s) of FLCN-AMPK-FNIP complex is regulated by Ser62 phosphorylation...
  9. ncbi request reprint Gene expression profile of DNA binding protein A transgenic mice
    Hiroshi Tobita
    Department of Pathology, Juntendo University School of Medicine, Hongo, Tokyo 113 8421, Japan
    Int J Oncol 29:673-9. 2006
    ..In conclusion, our present data suggested that dbpA could be positively involved in carcinogenesis by changing the expression profiles of cellular genes...
  10. ncbi request reprint Transcription of dbpA, a Y box binding protein, is positively regulated by E2F1: implications in hepatocarcinogenesis
    Yasuo Arakawa
    Department of Experimental Pathology, Cancer Institute, Japanese Fundation of Cancer Research, Tokyo, Japan
    Biochem Biophys Res Commun 322:297-302. 2004
    ..Thus, expression of dbpA was positively regulated by E2F1, suggesting that one of the effects of E2F1 on cell proliferation might be mediated by dbpA at the carcinogenesis step...
  11. ncbi request reprint Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma
    Koichi Inami
    Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Oncol Rep 20:1375-80. 2008
    ..N-ERC/mesothelin was not useful as a serum marker of pancreatic ductal carcinoma, but because of frequent expression, C-ERC/mesothelin might be useful as a target of molecular imaging and immunotherapy...
  12. doi request reprint Sensitive and specific new enzyme-linked immunosorbent assay for N-ERC/mesothelin increases its potential as a useful serum tumor marker for mesothelioma
    Kazu Shiomi
    Department of General Thoracic Surgery, Respiratory Medicine, Human Pathology, Juntendo University, School of Medicine, Tokyo, Japan
    Clin Cancer Res 14:1431-7. 2008
    ..It would be very useful to identify a tumor marker that could be used for screening to enable more diagnoses to be made at an early, treatable stage...
  13. ncbi request reprint Renal carcinogenesis: genotype, phenotype and dramatype
    Okio Hino
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455
    Cancer Sci 94:142-7. 2003
    ....
  14. doi request reprint Antitumor activity of anti-C-ERC/mesothelin monoclonal antibody in vivo
    Koichi Inami
    Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
    Cancer Sci 101:969-74. 2010
    ..Thus, 22A31 induced NK cell-mediated ADCC and exerted antitumor activity in vivo. 22A31 could have potential as a therapeutic tool to treat C-ERC/mesothelin-expressing cancers including mesothelioma...
  15. ncbi request reprint Suppression of cell death by the secretory form of N-terminal ERC/mesothelin
    Tegexibaiyin Wang
    Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Int J Mol Med 26:185-91. 2010
    ..The culture medium containing the secretory N-ERC also had the activity to increase the number of cells. Our data suggested that one of the full-ERC functions reported previously was mediated by the secretory N-ERC...
  16. ncbi request reprint The endoplasmic reticulum stress-inducible protein Niban regulates eIF2alpha and S6K1/4E-BP1 phosphorylation
    Guo Dong Sun
    Department of Pathology and Oncology, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 360:181-7. 2007
    ..Additionally, suppression of NIBAN expression in HeLa cells promoted apoptosis. Together these results suggest that Niban is involved in the ER stress response, and that Niban can modulate cell death signaling by regulating translation...
  17. doi request reprint Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway
    Xianghua Piao
    Department of Pathology and Oncology, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 389:16-21. 2009
    ..Interestingly, our results also suggest that the complex formation of FLCN with AMPK is modulated by FLCN phosphorylation. These results suggest that FLCN is involved in a novel mechanism of signal transduction downstream of tuberin...
  18. doi request reprint Frequent expression of Niban in head and neck squamous cell carcinoma and squamous dysplasia
    Shin Ito
    Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo, Japan
    Head Neck 32:96-103. 2010
    ..Niban was initially identified in the Eker rat, a model of renal carcinogenesis. We examined Niban expression in head and neck squamous cell carcinoma (HNSCC) and head and neck dysplastic lesions...
  19. ncbi request reprint Niban gene is commonly expressed in the renal tumors: a new candidate marker for renal carcinogenesis
    Hiroyuki Adachi
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Oncogene 23:3495-500. 2004
    ..Thus, Niban was commonly expressed in renal carcinomas and might be a new marker for renal carcinogenesis...
  20. ncbi request reprint Presence of a modifier gene(s) affecting early renal carcinogenesis in the Tsc2 mutant (Eker) rat model
    Yasushi Kikuchi
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Int J Oncol 24:75-80. 2004
    ..We used this ENU system to perform a backcross experiment [F1(Eker x BN) x Eker] and finally succeeded in mapping a new modifier locus on rat chromosome 5 (the LOD score of the D5Rat12 was 3.13)...
  21. ncbi request reprint The up-regulation of Y-box binding proteins (DNA binding protein A and Y-box binding protein-1) as prognostic markers of hepatocellular carcinoma
    Mahmut Yasen
    Second Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
    Clin Cancer Res 11:7354-61. 2005
    ..The purpose of this study is to examine the significance of the expression of dbpA or of the T-to-G transversion in the dbpA promoter region, which enhances the promoter activity in vitro, for the progression of hepatocellular carcinoma...
  22. ncbi request reprint A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto's thyroiditis
    Fumihiko Matsumoto
    Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo, Japan
    Hum Pathol 37:1592-600. 2006
    ..3) Niban may be a molecular marker of the oxyphilic phenotype under various conditions. Further functional studies of Niban will clarify the role of Niban in various thyroid lesions...
  23. pmc A germ-line insertion in the Birt-Hogg-Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer
    Kazuo Okimoto
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Proc Natl Acad Sci U S A 101:2023-7. 2004
    ..The Nihon rat may therefore provide insights into a tumor-suppressor gene that is related to renal carcinogenesis and an animal model of human BHD syndrome...
  24. doi request reprint Deficiency of the Erc/mesothelin gene ameliorates renal carcinogenesis in Tsc2 knockout mice
    Danqing Zhang
    Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo, Japan
    Cancer Sci 102:720-7. 2011
    ..This suggests that Erc/mesothelin may have an important role in the promotion and/or maintenance of carcinogenesis by influencing cell-substrate adhesion via the integrin-related signal pathway...
  25. doi request reprint DNA binding protein A expression and methylation status in hepatocellular carcinoma and the adjacent tissue
    Mahmut Yasen
    Department of Hepato Biliary Pancreatic Surgery, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Oncol 40:789-97. 2012
    ..Our results suggest that the high expression of dbpA in the hypercarcinogenic state is an indicator of poor prognosis...
  26. ncbi request reprint N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo
    Shuji Momose
    Department of Pathology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda tsujimichi, Kawagoe, Saitama 350 8550, Japan
    Biochem Biophys Res Commun 356:693-8. 2007
    ..Thus, the functional domains of N-terminal hamartin binding and C-terminal tumor suppression in tuberin can separate in vivo...
  27. ncbi request reprint Somatic mutation and SNP in the promoter of dbpA and human hepatocarcinogenesis
    Junpei Hayashi
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Int J Oncol 21:847-50. 2002
    ..Our results suggested the biological significance of the transversion of dbpA's promoter region as one of the factors accelerating hepatocarcinogenesis...
  28. doi request reprint Osteopontin expression in pulmonary tumor thrombotic microangiopathy caused by gastric carcinoma
    Fumiyuki Takahashi
    Department of Respiratory Medicine, Juntendo University, School of Medicine, Tokyo, Japan
    Pathol Int 59:752-6. 2009
    ..To the best of the authors' knowledge this is the first report to demonstrate the possible involvement of OPN in PTTM. It is postulated that OPN is one of the candidate molecules for the development of PTTM...
  29. pmc TSC1 controls distribution of actin fibers through its effect on function of Rho family of small GTPases and regulates cell migration and polarity
    Maki Ohsawa
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    PLoS ONE 8:e54503. 2013
    ..These results suggest that TSC1 regulates cell polarity-associated formation of actin fibers through the spatial regulation of Rho family of small GTPases...
  30. ncbi request reprint Revisit: Yamagiwa's Carcinogenesis
    Okio Hino
    Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo, Japan
    Oncology 72:1. 2007
  31. ncbi request reprint Birt-Hogg-Dubé (BHD) gene mutations in human gastric cancer with high frequency microsatellite instability
    Wenquan Jiang
    Department of Surgery, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Cancer Lett 248:103-11. 2007
    ..Taken together, these findings show that the BHD gene is a rare target in MSI-high gastric cancer, and BHD mutation tends to occur downstream in the mutational events of other major MSI-high target genes...
  32. ncbi request reprint Impact of renal failure on the tumor markers of mesothelioma, N-ERC/mesothelin and osteopontin
    Kazu Shiomi
    Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan
    Anticancer Res 31:1427-30. 2011
    ..We examined whether renal dysfunction influences blood concentrations of promising new tumour markers, N-ERC/mesothelin (N-ERC) and osteopontin (OPN), to an important degree...
  33. ncbi request reprint Novel ELISA system for detection of N-ERC/mesothelin in the sera of mesothelioma patients
    Kazu Shiomi
    Department of General Thoracic Surgery, Respiratory Medicine, Juntendo University, School of Medicine, 2 1 1 Hongo, Tokyo 113 8421, Japan
    Cancer Sci 97:928-32. 2006
    ..In conclusion, N-ERC/mesothelin is a promising candidate tumor marker for mesothelioma...
  34. doi request reprint Overexpression of GLUT-1 in the invasion front is associated with depth of oral squamous cell carcinoma and prognosis
    Shinichi Ohba
    Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo, Japan
    J Oral Pathol Med 39:74-8. 2010
    ..We hypothesized that a oral squamous cell carcinoma, characterized by high frequency of lymph node metastasis, distant metastasis or local recurrences, was associated with GLUT-1 overexpression in invasion front...
  35. ncbi request reprint Identification of the coding sequences responsible for Tsc2-mediated tumor suppression using a transgenic rat system
    Shuji Momose
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo, Japan
    Hum Mol Genet 11:2997-3006. 2002
    ..Tuberin could function as a tumor suppressor without binding to hamartin. The requirement of the functional domain(s) of tuberin might differ for prevention of embryonic lethality and for suppression of renal carcinogenesis...
  36. ncbi request reprint [Molecular mechanism of HBV-related hepatocarcinogenesis]
    Hiroshi Tobita
    Department of Experimental Pathology, Cancer Institute
    Nihon Rinsho 62:367-71. 2004
  37. ncbi request reprint Frequent down-regulation of HIVEP2 in human breast cancer
    Hiroaki Fujii
    Department of Pathology II, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Breast Cancer Res Treat 91:103-12. 2005
    ....
  38. pmc Clinical and genetic spectrum of Birt-Hogg-Dube syndrome patients in whom pneumothorax and/or multiple lung cysts are the presenting feature
    Makiko Kunogi
    Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan
    J Med Genet 47:281-7. 2010
    ..Genetic studies have disclosed that the clinical picture as well as responsible germline FLCN mutations are diverse...
  39. doi request reprint siRNA-mediated Erc gene silencing suppresses tumor growth in Tsc2 mutant renal carcinoma model
    Osamu Imamura
    Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo, Japan
    Cancer Lett 268:278-85. 2008
    ..Then, by using siRNA microspheres, we found that the suppression of Erc/mesothelin caused growth inhibition of Tsc2 mutant renal carcinoma cells in tumor implantation experiments in mice...
  40. doi request reprint NP-1250, an ABCG2 inhibitor, induces apoptotic cell death in mitoxantrone-resistant breast carcinoma MCF7 cells via a caspase-independent pathway
    Masumi Ito
    Department of Pathology and Oncology, Juntendo University School of Medicine, Bunkyo, Tokyo 113 8421, Japan
    Oncol Rep 29:1492-500. 2013
    ....
  41. pmc The N-ERC index is a novel monitoring and prognostic marker for advanced malignant pleural mesothelioma
    Takanori Mori
    Departments of Respiratory Medicine, Juntendo University, Graduate School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Thorac Dis 5:145-8. 2013
    ..The aim of this study is to investigate whether the serum N-ERC level can accurately predict the outcome in patients with MPM...
  42. pmc Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer
    Shinya Akatsuka
    Department of Pathology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    PLoS ONE 7:e43403. 2012
    ..Based on the characteristics of extensive genome alterations in human cancer, our results suggest that this chemical reaction may play a major role during human carcinogenesis...
  43. ncbi request reprint N-ethyl-N-hydroxyethylnitrosamine (EHEN)-induced renal and hepatocarcinogenesis in the tumor suppressor Tsc2 transgenic rat
    Nobuo Satake
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Cancer Lett 184:157-63. 2002
    ..These results suggest the presence of other target RC gene(s) in chemically (EHEN)-induced renal carcinogenesis. We observed no difference in the numbers and areas of the hepatic glutathione S-transferase placental type positive foci...
  44. ncbi request reprint Understanding the hypercarcinogenic state in chronic hepatitis: a clue to the prevention of human hepatocellular carcinoma
    Okio Hino
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 170 8455, Japan
    J Gastroenterol 37:883-7. 2002
    ..These conditions may be designated as the "hypercarcinogenic state". Our goal is to change the "hypercarcinogenic state" to the "normo- or hypocarcinogenic" state and to prevent HCC development...
  45. doi request reprint Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through the mTORC1 signaling pathway
    Hidehiro Okura
    Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo, Japan
    Int J Oncol 43:447-56. 2013
    ..Moreover, the dots were co-localized with p62/sequestosome-1 and ubiquitin. These findings imply that Rac1 distribution and/or its degradation may be regulated by tuberin through the mTORC1 signaling pathway...
  46. ncbi request reprint Mutation analysis of the TSC1 and TSC2 genes in Japanese patients with pulmonary lymphangioleiomyomatosis
    Teruhiko Sato
    Department of Respiratory Medicine Juntendo University, School of Medicine, Tokyo, Japan
    J Hum Genet 47:20-8. 2002
    ..However, our study indicates that a fraction of sporadic LAM can be a TSC1 disease; therefore, both TSC genes should be examined, even for patients with sporadic LAM...
  47. ncbi request reprint ERC/mesothelin as a marker for chemotherapeutic response in patients with mesothelioma
    Ken Tajima
    Department of Respiratory Medicine, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Anticancer Res 28:3933-6. 2008
    ..The aim of this study was to investigate whether serum N-ERC/mesothelin, an NH3-terminal fragment of mesothelin, and plasma OPN reflect chemotherapeutic effect in patients with mesothelioma...
  48. ncbi request reprint Frequent hypermethylation of RASSF1A in early flat-type colorectal tumors
    Naoto Sakamoto
    Department of Pathology II, Juntendo University, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo 113 8421, Japan
    Oncogene 23:8900-7. 2004
    ..An alternative cascade of abnormalities in RAS transduction pathways may be responsible for the flat morphology and aggressive nature of flat colorectal neoplasms...
  49. ncbi request reprint Hereditary renal carcinogenesis fitting Knudson's two-hit model: genotype, environment, and phenotype
    Okio Hino
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Genes Chromosomes Cancer 38:357-67. 2003
    ....
  50. ncbi request reprint Rapid multiple immunocytochemical staining method using microwave irradiation for intraoperative cytology
    Atsushi Furuhata
    Division of Biomedical Imaging Research, Graduate School of Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Acta Cytol 54:283-90. 2010
    ..To develop a more rapid and accurate staining procedure for intraoperative cytology through an assessment of a rapid multiple immunocytochemical staining method using microwave irradiation...
  51. ncbi request reprint [Federal headship of carcinogenesis--genotype, phenotype, and dramatype]
    Okio Hino
    Department of Pathology, Juntendo University School of Medicine
    Fukuoka Igaku Zasshi 96:1-4. 2005
  52. ncbi request reprint [Philosophy of cancer--guiding principle of transition and formative force of new era]
    Okio Hino
    Department of Pathology, Juntendo University School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 101:855-9. 2004
  53. ncbi request reprint Molecular aspects of human hepatocarcinogenesis mediated by inflammation: from hypercarcinogenic state to normo- or hypocarcinogenic state
    Tomoyuki Umeda
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Oncology 62:38-42. 2002
    ..Our goal, then, should be directed to the reversion of the 'hypercarcinogenic state' to the 'normo- or hypocarcinogenic state' so as to hopefully prevent or at least postpone the development of hepatocellular carcinoma...
  54. doi request reprint Folliculin regulates cyclin D1 expression through cis-acting elements in the 3' untranslated region of cyclin D1 mRNA
    Akiko Kawai
    Department of Pathology and Oncology, Juntendo University, School of Medicine, Tokyo 113 8421, Japan
    Int J Oncol 42:1597-604. 2013
    ..This effect was largely prevented by knockdown of BHD. Our results suggest that the post-transcriptional regulation of the CCND1 expression by BHD may be associated with microRNA(s) or RNA binding protein(s) that bind to the 3'UTR...
  55. doi request reprint HCV core protein promotes heparin binding EGF-like growth factor expression and activates Akt
    Hitomi Nakamura
    Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
    Hepatol Res 41:455-62. 2011
    ..This model indicates a new approach to mechanism of proliferation and anti-apoptosis in HCC. Conclusion:  HCV core protein is a potent activator of mitogenic and anti-apoptotic signaling involved in hepatocarcinogenesis...
  56. ncbi request reprint [An 80-year-old woman with progressive stroke, who had rheumatoid arthritis and antiphospholipid syndrome]
    Terubumi Watanabe
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    No To Shinkei 58:173-81. 2006
    ..Amyloid didn't deposit in the brain artery and the parenchyma. Pathologist concluded that her infarction was induced with multiple thrombus due to antiphospholipid syndrome...
  57. ncbi request reprint Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
    Xinsheng Gao
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9040, USA
    Nat Cell Biol 4:699-704. 2002
    ..Our studies identify Tsc1 and Tsc2 as regulators of the amino acid-TOR pathway and provide a new paradigm for how proteins involved in nutrient sensing function as tumour suppressors...
  58. doi request reprint MESOMARK kit detects C-ERC/mesothelin, but not SMRP with C-terminus
    Tatsuya Segawa
    Immuno Biological Laboratories Co Ltd, 5 1 Aramachi, Takasaki, Gunma 370 0831, Japan
    Biochem Biophys Res Commun 369:915-8. 2008
    ..This result showed that the SMRP detected with MESOMARK kit should be lack of soluble C-terminus and indistinguishable from C-ERC/mesothelin. Further study might be necessary to demonstrate the relationship between SMRP and mesothelin...
  59. ncbi request reprint Natural history of the Nihon rat model of BHD
    Kazuo Okimoto
    Toxicology Group, Safety Research Laboratories, Dainippon Pharmaceutical Co, Ltd, 33 94 Enoki cho, Suita, Osaka 564 0053, Japan
    Curr Mol Med 4:887-93. 2004
    ..Thus, the Nihon rat will contribute to understanding the BHD gene function and renal carcinogenesis...
  60. ncbi request reprint Ets protein Elf-1 bidirectionally suppresses transcriptional activities of the tumor suppressor Tsc2 gene and the repair-related Nth1 gene
    Satoshi Honda
    Department of Urology, Shimane Medical University, Shimane, Japan
    Mol Carcinog 37:122-9. 2003
    ..Our observations suggest that mechanisms that inactivate Tsc2 gene expression, such as promoter suppression, may exist...
  61. ncbi request reprint Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Int J Mol Med 18:425-32. 2006
    ..RB1CC1 preserved cell size without cell cycle progression especially in neuromuscular tissues, and the abundance contributed to the non-proliferating enlarged cell phenotype...
  62. ncbi request reprint Natural history of the Nihon (Bhd gene mutant) rat, a novel model for human Birt-Hogg-Dubé syndrome
    Mami Kouchi
    Toxicology Group, Safety Research Laboratories, Dainippon Sumitomo Pharma Co, Ltd, Enoki cho, Suita, Osaka, Japan
    Virchows Arch 448:463-71. 2006
    ..This rat model of hereditary RCC provides a useful tool for analyzing the series of events leading to renal tumorigenesis and for studying BHD gene functions...
  63. ncbi request reprint Human bladder tumors with 2-hit mutations of tumor suppressor gene TSC1 and decreased expression of p27
    Hiroyuki Adachi
    Department of Urology, Shimane Medical University, Izumo, Japan
    J Urol 170:601-4. 2003
    ..3. Furthermore, we also examined the expression of p27 because the TSC1 product is reported to influence the level of p27...
  64. ncbi request reprint Blood tests for asbestos-related mesothelioma
    Masahiro Maeda
    Immuno biological Laboratories Co, Ltd, Fujioka shi, Japan
    Oncology 71:26-31. 2006
    ..Recently, serum markers for the diagnosis of mesothelioma have been reported as candidates. In this paper, we mini-reviewed the potential utility of ELISA systems as serum diagnostic markers for asbestos-related mesothelioma...
  65. ncbi request reprint Establishment of the enzyme-linked immunosorbent assay system to detect the amino terminal secretory form of rat Erc/Mesothelin
    Masayuki Nakaishi
    Department of Urology, Ehime University School of Medicine, Shizukawa, Toh on, Ehime, Japan
    Cancer Sci 98:659-64. 2007
    ..We hope our ELISA to detect the soluble form of rat Erc/Mesothelin is useful in the rat model system to exploit the antimesothelioma therapy to be used in human cases...
  66. ncbi request reprint Down-regulation of cyclooxygenase-2 expression but up-regulation of cyclooxygenase-1 in renal carcinomas of the Eker (TSC2 gene mutant) rat model
    Toshihiro Okamoto
    Research Laboratories, Nippon Chemiphar Co, Ltd, Saitama 341 0005
    Cancer Sci 94:22-5. 2003
    ..In total, Cox-2 mRNA expression was down-regulated in eight out of ten Eker RCs and cell lines, while Cox-1 mRNA expression was up-regulated in nine out of ten Eker RCs and cell lines...
  67. ncbi request reprint Molecular tumor markers for asbestos-related mesothelioma: serum diagnostic markers
    Masahiro Maeda
    Immuno Biological Laboratories, Fujioka, Gunma, Japan
    Pathol Int 56:649-54. 2006
    ..It has also been found that N-ERC/mesothelin is very stable and plentiful in the blood. In the present paper the potential utility of molecular diagnostic markers is reviewed, including ELISA systems for asbestos-related mesothelioma...
  68. pmc Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression
    Li Ma
    Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 19:1779-86. 2005
    ....
  69. doi request reprint Establishment of a novel specific ELISA system for rat N- and C-ERC/mesothelin. Rat ERC/mesothelin in the body fluids of mice bearing mesothelioma
    Yoshiaki Hagiwara
    Immuno Biological Laboratories, 5 1 Aramachi, Takasaki shi, Gunma 370 0831, Japan
    Cancer Sci 99:666-70. 2008
    ..We hope these novel ELISA systems are useful in the rat model system to clarify the mechanism of asbestos-induced carcinogenesis and to develop new effective drugs for mesothelioma...
  70. ncbi request reprint Absence of allelic loss in cytomegalic neurons of cortical tuber in the Eker rat model of tuberous sclerosis
    Masashi Mizuguchi
    Department of Pediatrics, Jichi Medical School, Tochigi, 3, 311 1 Yakushiji, Minamikawachi, Kawachi gun, 329 0498, Tochigi, Japan
    Acta Neuropathol 107:47-52. 2004
    ..These findings were in sharp contrast to those of renal carcinoma cells deriving from allelic loss. Our results provide evidence that many if not all cytomegalic neurons of a cortical tuber occur in the absence of allelic loss...
  71. ncbi request reprint Malignant perivascular epithelioid cell tumor of the colon: report of a case with molecular analysis
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Japan
    Pathol Int 56:46-50. 2006
    ..The result suggests that the overexpression of cyclin D1 may play an important role in the tumorigenesis of PEComa. Because PEComas can behave in an aggressive manner, careful follow up is warranted...
  72. ncbi request reprint Tumor suppressor genes and the two-hit model of recessive oncogenesis: celebrating Alfred Knudson's 80th birthday
    Joseph R Testa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Genes Chromosomes Cancer 38:286-7. 2003
  73. ncbi request reprint A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis
    Takamasa Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan
    Cancer Res 65:203-9. 2005
    ..These results underscore the notion that mitochondrially generated oxidative stress can contribute to nuclear DNA damage, mutagenesis, and ultimately, tumorigenesis...
  74. ncbi request reprint Prepro-orexin mRNA expression in the rat brain is increased during pregnancy
    Kenji Kanenishi
    Department of Perinatology and Gynecology, Faculty of Medicine, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki, Kagawa 761 0793, Japan
    Neurosci Lett 368:73-7. 2004
    ..These results suggest that increased prepro-orexin mRNA levels at early gestational age in the maternal rat has a role on energy metabolism during pregnancy...
  75. ncbi request reprint Cloning of the Cav 1.3 (alpha1D) L-type Ca2+ channel from mouse and its expression in the liver
    Toshihiro Okamoto
    Research Laboratories, Nippon Chemiphar Co, Ltd, Saitama 341 0005, Japan
    Int J Mol Med 13:573-6. 2004
    ..The present results indicated that mouse Cav 1.3 exhibited 96% homology with human Cav 1.3 and was expressed in the liver. Thus, mouse hepatitis model seemed to be useful to screen DHP-CCB specific for Cav 1.3...
  76. ncbi request reprint Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway
    Yongheng Cao
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Disease, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 281:40242-51. 2006
    ..These data suggest a novel mechanism by which FoxO1 regulates the insulin signaling pathway through negative regulation of TSC2 function...
  77. ncbi request reprint GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress
    Ryosuke Watanabe
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Int J Mol Med 19:475-83. 2007
    ..GADD34 may find clinical potential as a target drug for the treatment of mTOR-associated diseases...
  78. ncbi request reprint Postoperative fibromatosis-type fibromas in the Bhd gene mutant (Nihon) rat
    Mami Kouchi
    Safety Research Laboratories, Dainippon Sumitomo Pharma Co Ltd, 33 94, Enoki cho, Suita, Osaka 564 0053, Japan
    Exp Toxicol Pathol 59:273-9. 2008
    ..Genetic factor should be involved in the occurrence of the tumor, since it was found only in the Nihon rats among many rats. Our present data suggest that Bhd gene mutation is not likely to be a candidate...
  79. doi request reprint Tuberous sclerosis complex 2 loss-of-function mutation regulates reactive oxygen species production through Rac1 activation
    Tsukasa Suzuki
    Department of Applied Biology and Chemistry, Tokyo University of Agriculture, 1 1 1 Sakuragaoka, Setagaya Ku, Tokyo 156 8502, Japan
    Biochem Biophys Res Commun 368:132-7. 2008
    ..These results indicate that loss-of-function mutated tuberin can activate Rac1 and thereby increase ROS production...
  80. pmc Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice
    Yutaka Shigeyama
    Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Mol Cell Biol 28:2971-9. 2008
    ..These results thus indicate that TSC2 regulates pancreatic beta-cell mass in a biphasic manner...
  81. ncbi request reprint Osthole prevents anti-Fas antibody-induced hepatitis in mice by affecting the caspase-3-mediated apoptotic pathway
    Toshihiro Okamoto
    Research Laboratories, Nippon Chemiphar Co, Ltd, 1 22 Hikokawato, Misato, Saitama 341 0005, Japan
    Biochem Pharmacol 65:677-81. 2003
    ..The present results show that osthole prevented anti-Fas antibody-induced hepatitis by inhibiting the Fas-mediated apoptotic pathway...
  82. ncbi request reprint HZE radiation effects for hereditary renal carcinomas
    Taeko Nakadai
    International Space Radiation Laboratory NIRS, Chiba, Japan
    Biol Sci Space 18:177-8. 2004
    ..Based on the dose-response relationship of the radiation-induced carcinoma, averaged RBE ware calculated to be 1.1 for C-ion, 1.6 for Fe-ion...
  83. ncbi request reprint VBP-1 is necessary for morphogenesis in Caenorhabditis elegans
    Harumi Ichimiya
    Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Oncol Rep 10:293-5. 2003
    ..Double-stranded RNA interference (RNAi) against VBP-1 resulted in an arrest of embryogenesis at morula stages. This suggests that the VBP-1 product is necessary for morphogenesis...