N Hattori

Summary

Affiliation: Juntendo University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease
    Kenya Nishioka
    Department of Neurology, Juntendo University School of Medicine, Hongo, Tokyo, Japan
    Ann Neurol 59:298-309. 2006
  2. doi request reprint Toxic effects of dopamine metabolism in Parkinson's disease
    Nobutaka Hattoria
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo, Tokyo 113 8421, Japan
    Parkinsonism Relat Disord 15:S35-8. 2009
  3. ncbi request reprint Animal models of Parkinson's disease: similarities and differences between the disease and models
    Nobutaka Hattori
    Department of Neurology, Juntendo University, School of Medicine, Tokyo, Japan
    Neuropathology 27:479-83. 2007
  4. ncbi request reprint Familial Parkinson's disease: a hint to elucidate the mechanisms of nigral degeneration
    Nobutaka Hattori
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo, 113 0033, Tokyo, Japan
    J Neurol 250:III2-10. 2003
  5. ncbi request reprint Appropriate dosing of pergolide in monotherapy and adjunctive therapy in Parkinson's disease
    Nobutaka Hattori
    Department of Neurology, Juntendo University School of Medicine, Japan
    Curr Opin Neurol 16:S21-5. 2003
  6. ncbi request reprint Pathogenetic mechanisms of parkin in Parkinson's disease
    Nobutaka Hattori
    Department of Neurology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Lancet 364:722-4. 2004
  7. ncbi request reprint Autosomal recessive juvenile parkinsonism: a key to understanding nigral degeneration in sporadic Parkinson's disease
    N Hattori
    Department of Neurology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan
    Neuropathology 20:S85-90. 2000
  8. ncbi request reprint Genotype in the 24-kDa subunit gene (NDUFV2) of mitochondrial complex I and susceptibility to Parkinson disease
    N Hattori
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Genomics 49:52-8. 1998
  9. ncbi request reprint Point mutations (Thr240Arg and Gln311Stop) [correction of Thr240Arg and Ala311Stop] in the Parkin gene
    N Hattori
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 249:754-8. 1998
  10. ncbi request reprint Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
    T Kitada
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Nature 392:605-8. 1998

Collaborators

Detail Information

Publications157 found, 100 shown here

  1. ncbi request reprint Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease
    Kenya Nishioka
    Department of Neurology, Juntendo University School of Medicine, Hongo, Tokyo, Japan
    Ann Neurol 59:298-309. 2006
    ..The objective of this study was to assess the frequency of SNCA multiplications among autosomal dominant hereditary Parkinson's disease (ADPD)...
  2. doi request reprint Toxic effects of dopamine metabolism in Parkinson's disease
    Nobutaka Hattoria
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo, Tokyo 113 8421, Japan
    Parkinsonism Relat Disord 15:S35-8. 2009
    ..In addition, HNE can modify alpha-synuclein (SNCA). Subsequently, this modification may trigger the aggregation of this protein. At a minimum, this modification could be associated with oligomer formation or fibrillation of SNCA...
  3. ncbi request reprint Animal models of Parkinson's disease: similarities and differences between the disease and models
    Nobutaka Hattori
    Department of Neurology, Juntendo University, School of Medicine, Tokyo, Japan
    Neuropathology 27:479-83. 2007
    ..Moreover, new PD models using neurotoxins have been reported. In this review, the similarities between human PD and PD models such as genetic mice and Drosophila models are reviewed...
  4. ncbi request reprint Familial Parkinson's disease: a hint to elucidate the mechanisms of nigral degeneration
    Nobutaka Hattori
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo, 113 0033, Tokyo, Japan
    J Neurol 250:III2-10. 2003
    ..Thus, identification and elucidation of the causative genes should enhance our understanding of the pathogenesis of not only familial PD, but also sporadic PD...
  5. ncbi request reprint Appropriate dosing of pergolide in monotherapy and adjunctive therapy in Parkinson's disease
    Nobutaka Hattori
    Department of Neurology, Juntendo University School of Medicine, Japan
    Curr Opin Neurol 16:S21-5. 2003
    ....
  6. ncbi request reprint Pathogenetic mechanisms of parkin in Parkinson's disease
    Nobutaka Hattori
    Department of Neurology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Lancet 364:722-4. 2004
    ..Identification of the causative genes for familial Parkinson's diseases allow study of the pathogenesis of the disease at the molecular level...
  7. ncbi request reprint Autosomal recessive juvenile parkinsonism: a key to understanding nigral degeneration in sporadic Parkinson's disease
    N Hattori
    Department of Neurology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan
    Neuropathology 20:S85-90. 2000
    ..Our findings should enhance the exploration of the mechanisms of neuronal death in PD as well as other neurodegenerative disorders of which variable inclusion bodies are observed...
  8. ncbi request reprint Genotype in the 24-kDa subunit gene (NDUFV2) of mitochondrial complex I and susceptibility to Parkinson disease
    N Hattori
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Genomics 49:52-8. 1998
    ..40 (95% CI: 1.18-4.88). NDUFV2 constitutes one genetic risk factor for PD, and the mutation may well be a cause of complex I deficiency in this disease...
  9. ncbi request reprint Point mutations (Thr240Arg and Gln311Stop) [correction of Thr240Arg and Ala311Stop] in the Parkin gene
    N Hattori
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 249:754-8. 1998
    ..Identification of its mutation provides an important clue as to the role of the Parkin protein in degeneration of the substantia nigra in the brain of AR-JP patients...
  10. ncbi request reprint Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
    T Kitada
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Nature 392:605-8. 1998
    ..Mutations in the newly identified gene appear to be responsible for the pathogenesis of AR-JP, and we have therefore named the protein product 'Parkin'...
  11. doi request reprint Protective role of hematopoietic prostaglandin D synthase in transient focal cerebral ischemia in mice
    M Liu
    Research Institute for Disease of Old Age, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Neuroscience 163:296-307. 2009
    ..Our results demonstrated that the neuroprotective effects of HPGDS in our model are mediated by suppression of activation and infiltration of inflammatory cells...
  12. pmc Age associated axonal features in HNPP with 17p11.2 deletion in Japan
    H Koike
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Neurol Neurosurg Psychiatry 76:1109-14. 2005
    ..To clarify age related changes in the clinicopathological features of hereditary neuropathy with liability to pressure palsy (HNPP) in Japanese patients with deletion of 17p11.2, particularly concerning axonal abnormalities...
  13. ncbi request reprint Expression of glial cell line-derived neurotrophic factor and GDNFR-alpha mRNAs in human peripheral neuropathies
    M Yamamoto
    Department of Neurology, Nagoya University School of Medicine, Japan
    Brain Res 809:175-81. 1998
    ..The GDNF and GDNFR-alpha expression in the diseased human nerves is regulated by an underlying pathology-related process, and could play a role in peripheral nerve repair...
  14. ncbi request reprint Colocalization of Bcl-2 and 4-hydroxynonenal modified proteins in microglial cells and neurons of rat brain following transient focal ischemia
    T Urabe
    Department of Neurology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan
    Neurosci Lett 247:159-62. 1998
    ..Bcl-2 may play an important role in the antioxidant system promoting survival of the neurons and activated microglia following reperfusion injury...
  15. ncbi request reprint Ataxic vs painful form of paraneoplastic neuropathy
    Y Oki
    Department of Neurology, Nagoya University, Graduate School of Medicine, Nagoya, Japan
    Neurology 69:564-72. 2007
    ..To characterize the clinicopathologic features of ataxic and painful forms of paraneoplastic neuropathy...
  16. ncbi request reprint Clinicopathologic features of nonsystemic vasculitic neuropathy and microscopic polyangiitis-associated neuropathy: a comparative study
    M Sugiura
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Neurol Sci 241:31-7. 2006
    ..To compare clinicopathologic findings in nonsystemic vasculitic neuropathy (NSVN) and microscopic polyangiitis-associated neuropathy (MPAN)...
  17. ncbi request reprint Pathology of early- vs late-onset TTR Met30 familial amyloid polyneuropathy
    H Koike
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neurology 63:129-38. 2004
    ..Late-onset type I familial amyloid polyneuropathy (FAP TTR Met30) cases unrelated to endemic foci in Japan show clinical features setting them apart from early-onset cases in endemic foci...
  18. doi request reprint Neuropathic pain correlates with myelinated fibre loss and cytokine profile in POEMS syndrome
    H Koike
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neurol Neurosurg Psychiatry 79:1171-9. 2008
    ..To reveal characteristic clinicopathological correlates of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes (POEMS) syndrome...
  19. ncbi request reprint Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients
    H Shimura
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Ann Neurol 45:668-72. 1999
    ..Parkin protein was not decreased in the brains of sporadic PD patients. Immunoreactivity was detected in a few Lewy bodies. Parkin protein was located in both the Golgi complex and cytosol...
  20. ncbi request reprint Developmental changes in the expression of parkin and UbcR7, a parkin-interacting and ubiquitin-conjugating enzyme, in rat brain
    M Wang
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    J Neurochem 77:1561-8. 2001
    ..Co-expression of UbcR7 with parkin suggests that UbcR7 may interact with parkin in vivo for ubiquitination of yet unidentified target protein(s)...
  21. ncbi request reprint Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism
    Y Li
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo, Tokyo 113 0033, Japan
    Neurology 64:1955-7. 2005
    ..Clinically, the patients with the deletion had dementia. Thus, early-onset PD with dementia may be considered PINK1-linked parkinsonism. Furthermore, patients with PINK1 mutations form 8.9% of parkin- and DJ-1-negative ARPD families...
  22. ncbi request reprint Clinical and electrophysiologic correlates of IVIg responsiveness in CIDP
    M Iijima
    Department of Neurology, Nagoya University Graduate School of Medicine, Tsurumai, Nagoya, Japan
    Neurology 64:1471-5. 2005
    ..Male gender, longer disease duration, and slow progression of symptoms were also associated with IVIg unresponsiveness. Features suggesting axonal dysfunction in peripheral nerves indicated IVIg unresponsiveness in CIDP...
  23. ncbi request reprint Familial Parkinson's disease. Alpha-synuclein and parkin
    Y Mizuno
    Department of Neurology, Juntendo University School of Medicine, Tokyo 113-8421, Japan
    Adv Neurol 86:13-21. 2001
    ..In addition, in sporadic PD, normal alpha-synuclein shows an increased tendency to self-aggregate. Thus, altered axonal transport of presynaptic proteins appears to play a crucial role in neurodegeneration in PD...
  24. doi request reprint Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP
    M Iijima
    Department of Neurology, Nagoya University Graduate School of Medicine, Aichi, Japan
    Neurology 73:1348-52. 2009
    ..In this study, we examined whether particular genetic factors influence the therapeutic responsiveness of patients with CIDP...
  25. pmc Postgastrectomy polyneuropathy with thiamine deficiency
    H Koike
    Department of Neurology, Nagoya University School of Medicine, Nagoya 466-8550, Japan
    J Neurol Neurosurg Psychiatry 71:357-62. 2001
    ..CONCLUSIONS: Various symptoms were seen in patients with postgastrectomy neuropathy. Thiamine deficiency should be considered in the differential diagnosis of motor-sensory polyneuropathy after gastrectomy...
  26. ncbi request reprint Parkin and Parkinson's disease
    Y Mizuno
    Department of Neurology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan
    Curr Opin Neurol 14:477-82. 2001
    ..In this review article, we evaluate the developments in this area published since 1 February 2000...
  27. ncbi request reprint Painful alcoholic polyneuropathy with predominant small-fiber loss and normal thiamine status
    H Koike
    Department of Neurology, Nagoya University School of Medicine, Japan
    Neurology 56:1727-32. 2001
    ..Sensory-dominant involvement with prominent neuropathic pain is characteristic of alcoholic neuropathy when thiamine deficiency is not involved, supporting the view of direct neurotoxic effect by alcohol or its metabolites...
  28. ncbi request reprint Chronic brain ischemia induces the expression of glial glutamate transporter EAAT2 in subcortical white matter
    Y Yatomi
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Neuroscience 244:113-21. 2013
    ..Our findings suggest important roles for up-regulated EAAT2 in chronic brain ischemia especially in the regulation of high-affinity of extracellular glutamate and minimization of white matter damage...
  29. ncbi request reprint Neuronal intranuclear hyaline inclusion disease showing motor-sensory and autonomic neuropathy
    J Sone
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Neurology 65:1538-43. 2005
    ....
  30. ncbi request reprint Pathology-related differential expression regulation of NGF, GDNF, CNTF, and IL-6 mRNAs in human vasculitic neuropathy
    M Yamamoto
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
    Muscle Nerve 24:830-3. 2001
    ..These findings indicate that these neurotrophic factors are differentially expressed temporally and spatially in the vasculitic nerve lesion by an underlying pathology-related process...
  31. ncbi request reprint Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
    H Shimura
    Department of Neurology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Nat Genet 25:302-5. 2000
    ....
  32. ncbi request reprint Accumulation of 4-hydroxynonenal-modified proteins in hippocampal CA1 pyramidal neurons precedes delayed neuronal damage in the gerbil brain
    T Urabe
    Department of Neurology, Juntendo University School of Medicine, 113 0033, Tokyo, Japan
    Neuroscience 100:241-50. 2000
    ..We conclude that 4-hydroxy-2-nonenal may be a key mediator of the oxidative stress-induced neuronal signaling pathway and may have an important role in modifying delayed neuronal death...
  33. ncbi request reprint PAL31 expression in rat trophoblast giant cells
    M Oda
    Laboratory of Cellular Biochemistry, Animal Resource Sciences/Veterinary Medical Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan
    Biochem Biophys Res Commun 287:721-6. 2001
    ..PAL31 is suggested to play a role in the endoreduplication distinct from the usual DNA duplication...
  34. ncbi request reprint Parkin is associated with cellular vesicles
    S I Kubo
    Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo 113-8421, Japan
    J Neurochem 78:42-54. 2001
    ..We demonstrated the ability of parkin to bind to the membranes through a broad region except for the ubiquitin-like domain. The significance of SV localization of parkin is discussed...
  35. ncbi request reprint Age of onset influences clinical features of chronic inflammatory demyelinating polyneuropathy
    N Hattori
    Department of Neurology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan
    J Neurol Sci 184:57-63. 2001
    ..Clinical features of CIDP differ by age of onset, which is a factor to consider in diagnosis, therapy, and prognosis...
  36. doi request reprint Phenotypic spectrum of patients with PLA2G6 mutation and PARK14-linked parkinsonism
    H Yoshino
    Research Institute for Diseases of Old Age, Juntendo University School of Medicine, Tokyo, Japan
    Neurology 75:1356-61. 2010
    ..Recently, PLA2G6 was also reported as the causative gene for early-onset PARK14-linked dystonia-parkinsonism...
  37. ncbi request reprint PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations
    Y Hatano
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Neurology 63:1482-5. 2004
    ..88 at D1S2732. The results indicate worldwide distribution of PARK6-linked parkinsonism...
  38. ncbi request reprint PAL31, a nuclear protein required for progression to the S phase
    W Sun
    Laboratory of Cellular Biochemistry, Animal Resource Sciences Veterinary Medical Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Biochem Biophys Res Commun 280:1048-54. 2001
    ..Furthermore, the antisense oligonucleotide for PAL31 severely inhibited the proliferation of Nb2 cells by inhibiting cells progressing to the S phase. Thus, PAL31 is a nuclear protein associated with cell cycle progression...
  39. ncbi request reprint Crucial role for Ser133-phosphorylated form of cyclic AMP-responsive element binding protein signaling in the differentiation and survival of neural progenitors under chronic cerebral hypoperfusion
    N Miyamoto
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Neuroscience 162:525-36. 2009
    ..Our results indicated that cAMP-responsive element binding protein signaling is a key mediator of neurogenesis after prolonged hypoperfusion and provide the basis for new regenerative therapies for ischemic brain injury...
  40. doi request reprint Cilostazol attenuates ischemic brain injury and enhances neurogenesis in the subventricular zone of adult mice after transient focal cerebral ischemia
    Y Tanaka
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Neuroscience 171:1367-76. 2010
    ..The results indicated that cilostazol enhanced neural progenitor cell generation in both ipsilateral SVZ and peri-infarct area through CREB-mediated signaling pathway after focal ischemia...
  41. pmc Intravenous immunoglobulin therapy markedly ameliorates muscle weakness and severe pain in proximal diabetic neuropathy
    Y Kawagashira
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Neurol Neurosurg Psychiatry 78:899-901. 2007
    ..The present case suggests that IVIg therapy may be effective for the relief of pain in PDN...
  42. ncbi request reprint DNA methylation variation in cloned mice
    J Ohgane
    Cellular Biochemistry, Animal Resource Sciences/Veterinary Medical Sciences, The University of Tokyo, Tokyo, Japan
    Genesis 30:45-50. 2001
    ..Individual cloned animals have different methylation aberrations. In other words, cloned animals are by no means perfect copies of the original animals as far as the methylation status of genomic DNA is concerned...
  43. ncbi request reprint Prevalence and incidence rates of chronic inflammatory demyelinating polyneuropathy in the Japanese population
    M Iijima
    Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, 466 8550 Nagoya, Japan
    J Neurol Neurosurg Psychiatry 79:1040-3. 2008
    ..To characterise the epidemiological features of chronic inflammatory demyelinating polyneuropathy (CIDP) in the Japanese population, this study performed a nationwide assessment of the prevalence and incidence rates in Japan...
  44. ncbi request reprint A microdeletion of D6S305 in a family of autosomal recessive juvenile parkinsonism (PARK2)
    H Matsumine
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Genomics 49:143-6. 1998
    ..An exon search in a deleted segment or in the relatively small-sized genomic clones harboring D6S305 may enormously facilitate the cloning procedure of the ARJP gene...
  45. ncbi request reprint A novel missense mutation in the early growth response 2 gene associated with late-onset Charcot--Marie--Tooth disease type 1
    T Yoshihara
    Department of Neurology, Nagoya University School of Medicine, Nagoya 466, Japan
    J Neurol Sci 184:149-53. 2001
    ..This report suggests that the EGR2 mutation represents divergent phenotypes at codon 381, which may be a mutation hotspot...
  46. pmc An axonal form of Charcot-Marie-Tooth disease showing distinctive features in association with mutations in the peripheral myelin protein zero gene (Thr124Met or Asp75Val)
    K Misu
    Department of Neurology, Nagoya University School of Medicine, 65 Tsurumai cho Showa ku Nagoya 466 8550, Japan
    J Neurol Neurosurg Psychiatry 69:806-11. 2000
    ..Seven families were studied with an axonal form of Charcot-Marie-Tooth disease (CMT) associated with mutations in the peripheral myelin protein zero (MPZ) gene-Thr124Met or Asp75Val...
  47. ncbi request reprint Expression of mRNAs for ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and their receptors (CNTFR alpha, LIFR beta, IL-6R alpha, and gp130) in human peripheral neuropathies
    Y Ito
    Department of Neurology, Nagoya University School of Medicine, Japan
    Neurochem Res 26:51-8. 2001
    ....
  48. ncbi request reprint Wide range of lineages of cells expressing nerve growth factor mRNA in the nerve lesions of patients with vasculitic neuropathy: an implication of endoneurial macrophage for nerve regeneration
    N Mitsuma
    Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 8550, Japan
    Neuroscience 129:109-17. 2004
    ....
  49. ncbi request reprint [Parkin gene and its function; a key to understand nigral degeneration]
    N Hattori
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Rinsho Shinkeigaku 39:1259-61. 1999
    ..Parkin protein was located in both Golgi complex and cytosol. Taken together, the Parkin protein may play a role in vesicular transport system in association with the Golgi complex...
  50. ncbi request reprint Edaravone attenuates white matter lesions through endothelial protection in a rat chronic hypoperfusion model
    Y Ueno
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Neuroscience 162:317-27. 2009
    ....
  51. ncbi request reprint ANGPTL4 is a secreted tumor suppressor that inhibits angiogenesis
    E Okochi-Takada
    Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan
    Oncogene 33:2273-8. 2014
    ..These showed that ANGPTL4 is a genetically and epigenetically inactivated secreted tumor suppressor that inhibits tumor angiogenesis. ..
  52. doi request reprint Efficacy and safety of a once-daily extended-release formulation of pramipexole switched from an immediate-release formulation in patients with advanced Parkinson's disease: results from an open-label study
    M Takanashi
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Drug Res (Stuttg) 63:639-43. 2013
    ..In conclusion, PPX-ER can be considered as a useful treatment option when PPX-IR needs to be switched to other dopamine agonists.This study is registered with UMIN-CTR (UMIN000006521)...
  53. doi request reprint Visceral fat accumulation is associated with cerebral small vessel disease
    K Yamashiro
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Eur J Neurol 21:667-73. 2014
    ..Whether visceral fat accumulation, as measured by computed tomography (CT), is an independent risk factor for the presence of cerebral small vessel disease (SVD) was investigated...
  54. doi request reprint PARK9-linked parkinsonism in eastern Asia: mutation detection in ATP13A2 and clinical phenotype
    Y P Ning
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Neurology 70:1491-3. 2008
  55. doi request reprint Clinicopathologic study of a SNCA gene duplication patient with Parkinson disease and dementia
    T Obi
    Department of Neurology, Shizuoka Institute of Epilepsy and Neurological Disorders, Tokyo, Japan
    Neurology 70:238-41. 2008
  56. pmc Intravenous immunoglobulin treatment in painful sensory neuropathy without sensory ataxia associated with Sjögren's syndrome
    M Kizawa
    Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai cho Showa ku, Nagoya 466 8550, Japan
    J Neurol Neurosurg Psychiatry 77:967-9. 2006
    ..Other patients with painful sensory neuropathy associated with Sjögren's syndrome may also be candidates for intravenous Ig treatment...
  57. ncbi request reprint [A 64-year-old man with parkinsonism as an initial symptom followed by dementia associated with marked abnormal behaviours]
    A Suzuki
    Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo 113-8421, Japan
    No To Shinkei 53:1075-87. 2001
    ..However, the inferior olivary nucleus was intact...
  58. pmc Sjögren's syndrome associated painful sensory neuropathy without sensory ataxia
    K Mori
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neurol Neurosurg Psychiatry 74:1320-2. 2003
  59. ncbi request reprint Structural organization and chromosomal localization of the human nuclear gene (NDUFV2) for the 24-kDa iron-sulfur subunit of complex I in mitochondrial respiratory chain
    N Hattori
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 216:771-7. 1995
    ..The sequences matching completely with the NRF-1 binding site and Mt elements were not identified in the flanking region. This gene was assigned to human chromosome 18 at region p11.3, by fluorescent in situ hybridization...
  60. ncbi request reprint Recessive Parkinson's disease
    Shin Ichiro Kubo
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Mov Disord 21:885-93. 2006
    ..Here, we review recent advances in knowledge about genes associated with recessive PD, including parkin, PINK1, and DJ-1...
  61. ncbi request reprint Prognosis of Parkinson's disease: time to stage III, IV, V, and to motor fluctuations
    Kenichi Sato
    Department of Neurology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan
    Mov Disord 21:1384-95. 2006
    ..Not many studies are available in the literature on the long-term outcome of PD, and our data would be useful as a reference...
  62. doi request reprint Mutations for Gaucher disease confer high susceptibility to Parkinson disease
    Jun Mitsui
    Department of Neurology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Arch Neurol 66:571-6. 2009
    ..Increased frequency of pathogenic variants in GBA, the causative gene for Gaucher disease, has been suggested to be associated with Parkinson disease (PD)...
  63. doi request reprint Familial Parkinsonism with digenic parkin and PINK1 mutations
    Manabu Funayama
    Research Institute for Diseases of Old Age, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Mov Disord 23:1461-5. 2008
    ..These findings indicate that PINK1 mutation might modify parkin mutation-positive Parkinsonism, and PINK1 mutations might be associated with psychiatric disorders...
  64. ncbi request reprint Haploinsufficiency at the alpha-synuclein gene underlies phenotypic severity in familial Parkinson's disease
    Hirokazu Kobayashi
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Brain 126:32-42. 2003
    ..Furthermore, these findings suggest that haploinsufficiency of alpha-synuclein mutations may contribute to disease progression in these forms of familial Parkinson's disease...
  65. doi request reprint Mutation analysis for DJ-1 in sporadic and familial parkinsonism: screening strategy in parkinsonism
    Hiroyuki Tomiyama
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo, Tokyo, Japan
    Neurosci Lett 455:159-61. 2009
    ....
  66. ncbi request reprint Correlation between levels of pigment epithelium-derived factor and vascular endothelial growth factor in the striatum of patients with Parkinson's disease
    Toru Yasuda
    Research Institute for Diseases of Old Ages, Juntendo University, Japan
    Exp Neurol 206:308-17. 2007
    ..The correlation between PEDF and VEGF striatal levels in PD patients suggests that concerted neurotrophic functions of these factors or structural changes in blood vessel walls play an important role in the pathophysiology of PD...
  67. ncbi request reprint Pharmacokinetics and effect of food after oral administration of prolonged-release tablets of ropinirole hydrochloride in Japanese patients with Parkinson's disease
    N Hattori
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    J Clin Pharm Ther 37:571-7. 2012
    ....
  68. ncbi request reprint ABO-incompatible auxiliary partial orthotopic liver transplant for late-onset familial amyloid polyneuropathy
    H Watanabe
    Department of Neurology, Nagoya University Graduate School of Medicine, 466 8550, Nagoya, Japan
    J Neurol Sci 195:63-6. 2002
    ..APOLT was chosen so the residual liver could sustain the patient in the event of hyperacute rejection. OLT is applicable to late-onset FAP transthyretin Met30, and APOLT can be considered in ABO-incompatible cases...
  69. ncbi request reprint Unmet needs of patients with Parkinson's disease: interview survey of patients and caregivers
    T Hatano
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    J Int Med Res 37:717-26. 2009
    ....
  70. ncbi request reprint DNA methylation regulates placental lactogen I gene expression
    J H Cho
    Laboratory of Cellular Biochemistry, Animal Resource Sciences/Veterinary Medical Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan
    Endocrinology 142:3389-96. 2001
    ..These results provide evidence that change in DNA methylation is the fundamental mechanism regulating the tissue-specific expression of the rat placental lactogen I gene...
  71. pmc Progress in the pathogenesis and genetics of Parkinson's disease
    Yoshikuni Mizuno
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo Bunkyo, Tokyo 113, Japan
    Philos Trans R Soc Lond B Biol Sci 363:2215-27. 2008
    ..Studies on the molecular mechanisms of nigral neuronal death in familial forms of PD will contribute further on the understanding of the pathogenesis of sporadic PD...
  72. ncbi request reprint Extensive hemispheric lesions with radiological evidence of blood-brain barrier integrity in a patient with neuromyelitis optica
    Shinji Saiki
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    J Neurol Sci 284:217-9. 2009
    ..The findings suggest possible involvement of deficient water elimination associated with seropositivity to NMO-IgG in the induction of vasogenic edema even in the presence of intact and functional BBB...
  73. doi request reprint Posterior hypoperfusion in Parkinson's disease with and without dementia measured with arterial spin labeling MRI
    Koji Kamagata
    Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan
    J Magn Reson Imaging 33:803-7. 2011
    ..To determine whether quantitative arterial spin labeling (ASL) can be used to evaluate regional cerebral blood flow in Parkinson's disease with dementia (PDD) and without dementia (PD)...
  74. ncbi request reprint Visual impairment in Parkinson's disease treated with amantadine: case report and review of the literature
    Shin Ichiro Kubo
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Parkinsonism Relat Disord 14:166-9. 2008
    ..The present report alerts neurologists and physicians in general to the peculiar ophthalmologic side effect of amantadine...
  75. doi request reprint Prevalence of abnormal glucose metabolism and insulin resistance among subtypes of ischemic stroke in Japanese patients
    Takao Urabe
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Stroke 40:1289-95. 2009
    ..The purpose was to assess the prevalence of disorders of glucose metabolism and insulin resistance in Japanese ischemic stroke patients with no history of diabetes by performing 75-gram oral glucose tolerance test (OGTT)...
  76. doi request reprint Prevalence of GJB2 causing recessive profound non-syndromic deafness in Japanese children
    Chieri Hayashi
    Department of Otorhinolaryngology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Int J Pediatr Otorhinolaryngol 75:211-4. 2011
    ..To clarify the relation between profound non-syndromic deafness and GJB2 mutation in Japanese children, we performed genetic testing for GJB2...
  77. ncbi request reprint Mobile aortic plaques are a cause of multiple brain infarcts seen on diffusion-weighted imaging
    Yuji Ueno
    Stroke Center, Department of Stroke Medicine, Kawasaki Medical School, Okayama, Japan
    Stroke 38:2470-6. 2007
    ..Recently, mobile aortic plaques (MAPs) have been proposed as embolic sources. However, the clinical characteristics of patients with MAPs are unclear...
  78. ncbi request reprint Pseudo-autosomal dominant inheritance of PARK2: two families with parkin gene mutations
    Tomonori Kobayashi
    Department of Neurology, Juntendo University School of Medicine, 2 1 1, Hongo, Bunkyo, Tokyo 113 8421, Japan
    J Neurol Sci 207:11-7. 2003
    ..We conclude that PARK2 cannot be excluded even if the mode of inheritance appears as autosomal dominant, when the affected patients are young...
  79. ncbi request reprint Isolated proximal leg paresis due to a small cortical infarction
    Kazuyuki Noda
    Department of Neurology, Juntendo University Shizuoka Hospital, Izunokuni
    Intern Med 49:1633-6. 2010
    ..It is clinically important to pay close attention to the contralateral top of the motor cortex when examining pure motor monoparesis of a proximal part of a lower extremity...
  80. doi request reprint The frequency of cardiac valvular regurgitation in Parkinson's disease
    Kazuo Yamashiro
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Mov Disord 23:935-41. 2008
    ..None of our patients showed severe regurgitation or was operated for valvular heart disease. The question as to whether or not longer duration of low dose dopamine agonist treatment would yield the same results needs further studies...
  81. ncbi request reprint Genotype-phenotype correlation: familial Parkinson disease
    Hideo Mori
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Neuropathology 23:90-4. 2003
    ..Investigations of these genes in familial PD have expanded their clinical and pathological phenotypes. However, to clarify the effect of mutations on these phenotypes, additional post-mortem neuropathological studies are required...
  82. ncbi request reprint Geographic and ethnic differences in frequencies of two polymorphisms (D/N394 and L/I272) of the parkin gene in sporadic Parkinson's disease
    Xiaobing Li
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo, 113 8421, Tokyo, Japan
    Parkinsonism Relat Disord 11:485-91. 2005
    ..Our results suggest that the frequencies of parkin polymorphisms are different among Asians and Caucasians...
  83. ncbi request reprint Parkinson's disease with and without REM sleep behaviour disorder: are there any clinical differences?
    Asako Yoritaka
    Department of Neurology, Juntendo Urayasu Hospital, Tokyo, Japan
    Eur Neurol 61:164-70. 2009
    ..In the early stage, RBD and autonomic system dysfunction are important factors in the progression of PD...
  84. ncbi request reprint [Molecular genetics of PINK1]
    Manabu Funayama
    Research Institute eases of Old Ages, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Brain Nerve 59:831-8. 2007
    ..In the other word, the mitochondrion is a good target for elucidating the pathogenesis of not only sporadic form but also monogenic form of PD...
  85. ncbi request reprint Accumulation of somatic mutation in mitochondrial DNA extracted from peripheral blood cells in diabetic patients
    T Nomiyama
    Department of Medicine, Metabolism and Endocrinology, School of Medicine, Juntendo University, Tokyo, Japan
    Diabetologia 45:1577-83. 2002
    ..Since diabetes can cause severe oxidative stress, we hypothesize that the accumulation of the somatic 3243 A to G mutation in mitochondrial DNA can be accelerated by diabetes...
  86. ncbi request reprint Focal cerebral ischemia/reperfusion injury in mice induces hematopoietic prostaglandin D synthase in microglia and macrophages
    M Liu
    Department of Neurology, Juntendo University School of Medicine 2 1 1, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Neuroscience 145:520-9. 2007
    ..We speculate that hematopoietic prostaglandin D synthase in the brain has different functions during early and late phases of ischemia...
  87. ncbi request reprint A case of epidermolysis bullosa simplex with a newly found missense mutation and polymorphism in the highly conserved helix termination motif among type I keratins, which was previously reported as a pathogenic missense mutation
    N Hattori
    Department of Dermatology, Fraternity Memorial Hospital, Tokyo, Japan
    Br J Dermatol 155:1062-3. 2006
  88. ncbi request reprint Polymorphism of the lipoprotein lipase gene and risk of atherothrombotic cerebral infarction in the Japanese
    Y Shimo-Nakanishi
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Stroke 32:1481-6. 2001
    ..We investigated whether these polymorphisms are associated with increased risk of ischemic cerebrovascular disease (CVD)...
  89. ncbi request reprint Induction and selective accumulation of mutant ubiquitin in CA1 pyramidal neurons after transient global ischemia
    K Yamashiro
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Neuroscience 147:71-9. 2007
    ..Our results indicate induction and selective accumulation of UBB(+1) protein in dying neurons of the CA1 region and suggest that UBB(+1) expression may be induced by proteasomal dysfunction after transient global ischemia...
  90. ncbi request reprint Chronic inflammatory demyelinating polyneuropathy presenting with features of GBS
    K Mori
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neurology 58:979-82. 2002
    ..Patients with apparent GBS who show persistent symptoms may benefit from corticosteroids or other treatment that is beneficial in the management of CIDP...
  91. doi request reprint Expanding the clinical phenotype of SNCA duplication carriers
    Kenya Nishioka
    Department of Neurology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Mov Disord 24:1811-9. 2009
    ..Further studies of SNCA duplication carriers will help identify disease-modifiers and may open novel avenues for future treatment...
  92. ncbi request reprint Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population
    Manabu Funayama
    Research Institute for Diseases of Old Age, Department of Neurology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, and Department of Neurology, Kagawa Prefectural Central Hospital, Takamatsu, Japan
    Neuroreport 18:273-5. 2007
    ..24x10(-4), odds ratio 2.63, 95% confidence interval 1.56-4.35). Our results suggest that the G2385R variant is a risk factor for sporadic Parkinson disease in the Asian population...
  93. ncbi request reprint Patent foramen ovale with atrial septal aneurysm may contribute to white matter lesions in stroke patients
    Yuji Ueno
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Cerebrovasc Dis 30:15-22. 2010
    ..The purpose of the present study was to assess the contribution of embolic etiologies, patent foramen ovale (PFO) and atrial septal aneurysm (ASA), to cerebral white matter lesions (WMLs) in ischemic stroke patients...
  94. doi request reprint Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease
    Toru Yasuda
    Research Institute for Diseases of Old Age, Juntendo University, Tokyo, Japan
    J Neurochem 108:932-44. 2009
    ..Our results support the hypothesis that PARK5 is caused by a gain-of-toxic-function of UCH-L1(Ile93Met) mutant, and suggest that regulation of UCH-L1 in nigral DA cells could be a future target for treatment of PD...
  95. doi request reprint Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan
    Hiroyuki Tomiyama
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Mov Disord 23:2344-8. 2008
    ..However, the familial aggregation and lack of any environment factors suggest that Kii ALS/PDC is caused by other yet unidentified genetic factors...
  96. ncbi request reprint Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries
    Hiroyuki Tomiyama
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Mov Disord 21:1102-8. 2006
    ..Clinical phenotypes including psychosis, dementia, and MIBG ratios are also heterogeneous, similar to neuropathology, in PD associated with LRRK2 mutations...
  97. doi request reprint Fatigue in Japanese patients with Parkinson's disease: a study using Parkinson fatigue scale
    Yasuyuki Okuma
    Department of Neurology, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokuni, Shizuoka 410 2295, Japan
    Mov Disord 24:1977-83. 2009
    ..Since fatigue is significantly related to QOL reduction, therapeutic interventions including treatment of sleep disturbance are important...
  98. ncbi request reprint Mutational analysis of fukutin gene in dilated cardiomyopathy and hypertrophic cardiomyopathy
    Takuro Arimura
    Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Circ J 73:158-61. 2009
    ..The current study was designed to further explore the association of FKTN mutations with DCM or hypertrophic cardiomyopathy (HCM)...
  99. doi request reprint Age at onset influences on wide-ranged clinical features of sporadic amyotrophic lateral sclerosis
    Naoki Atsuta
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neurol Sci 276:163-9. 2009
    ..To profile the detailed clinical features of sporadic amyotrophic lateral sclerosis (ALS) on large-scale samples in Japan...
  100. ncbi request reprint Nuclear localization of the 20S proteasome subunit in Parkinson's disease
    Atsuko Nakamura
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Neurosci Lett 406:43-8. 2006
    ..In contrast, no nuclear staining was observed in the same areas of brains of controls. Our results suggest that nuclear localization of 20S proteasome seems to be associated with the pathogenesis of PD...
  101. pmc 14-3-3eta is a novel regulator of parkin ubiquitin ligase
    Shigeto Sato
    Department of Neurology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan
    EMBO J 25:211-21. 2006
    ..Our findings indicate that 14-3-3eta is a regulator that functionally links parkin and alpha-SN. The alpha-SN-positive and 14-3-3eta-negative control of parkin activity sheds new light on the pathophysiological roles of parkin...