Hisaya Akiba

Summary

Affiliation: Juntendo University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo
    Hisaya Akiba
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 175:2340-8. 2005
  2. ncbi request reprint Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production
    Tomohide Yamazaki
    Department of Immunology, Juntendo University School of Medicine, Hongo, Tokyo, Japan
    J Immunol 175:1586-92. 2005
  3. ncbi request reprint Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses
    Fumihiko Tsushima
    Department of Molecular Immunology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Immunol 33:2773-82. 2003
  4. doi request reprint Contribution of B7RP-1/ICOS co-stimulation to lethal acute GVHD
    Junya Fujimura
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Transplant 14:540-8. 2010
  5. pmc IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2
    Tsuyoshi Ota
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Blood 106:184-92. 2005
  6. ncbi request reprint B7-H3 contributes to the development of pathogenic Th2 cells in a murine model of asthma
    Osamu Nagashima
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 181:4062-71. 2008
  7. ncbi request reprint Eradication of established tumors in mice by a combination antibody-based therapy
    Tomoyasu Uno
    Department of Immunology, Juntendo University School of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
    Nat Med 12:693-8. 2006
  8. doi request reprint TIM-4 has dual function in the induction and effector phases of murine arthritis
    Yoshiyuki Abe
    Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    J Immunol 191:4562-72. 2013
  9. doi request reprint Notch signaling confers antigen-presenting cell functions on mast cells
    Nobuhiro Nakano
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Allergy Clin Immunol 123:74-81.e1. 2009
  10. ncbi request reprint Blockade of B7-H1 suppresses the development of chronic intestinal inflammation
    Takanori Kanai
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Immunol 171:4156-63. 2003

Detail Information

Publications59

  1. ncbi request reprint The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo
    Hisaya Akiba
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 175:2340-8. 2005
    ..These results indicated that the ICOS/B7RP-1 interaction plays an essential role in the development of CXCR5+ T(FH) cells in vivo...
  2. ncbi request reprint Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production
    Tomohide Yamazaki
    Department of Immunology, Juntendo University School of Medicine, Hongo, Tokyo, Japan
    J Immunol 175:1586-92. 2005
    ....
  3. ncbi request reprint Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses
    Fumihiko Tsushima
    Department of Molecular Immunology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Immunol 33:2773-82. 2003
    ..Our results demonstrate the regulatory role of PD-1 and the differential roles of B7-H1 and B7-DC in hapten-induced immune responses. The PD-1-B7-H1 pathway may play a unique role in regulating inflammatory responses...
  4. doi request reprint Contribution of B7RP-1/ICOS co-stimulation to lethal acute GVHD
    Junya Fujimura
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Transplant 14:540-8. 2010
    ....
  5. pmc IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2
    Tsuyoshi Ota
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Blood 106:184-92. 2005
    ....
  6. ncbi request reprint B7-H3 contributes to the development of pathogenic Th2 cells in a murine model of asthma
    Osamu Nagashima
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 181:4062-71. 2008
    ..These results indicated an important role for B7-H3 in the development of pathogenic Th2 cells during the induction phase in a murine model of asthma...
  7. ncbi request reprint Eradication of established tumors in mice by a combination antibody-based therapy
    Tomoyasu Uno
    Department of Immunology, Juntendo University School of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
    Nat Med 12:693-8. 2006
    ..These results in mice indicate that a rational monoclonal antibody-based therapy that both causes tumor-cell apoptosis through DR5 and activates T cells may be an effective strategy for cancer immunotherapy in humans...
  8. doi request reprint TIM-4 has dual function in the induction and effector phases of murine arthritis
    Yoshiyuki Abe
    Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    J Immunol 191:4562-72. 2013
    ....
  9. doi request reprint Notch signaling confers antigen-presenting cell functions on mast cells
    Nobuhiro Nakano
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Allergy Clin Immunol 123:74-81.e1. 2009
    ..Notch signaling is involved in cell fate determination along with the development of the immune system. However, very little is known about the role for Notch signaling in mast cells...
  10. ncbi request reprint Blockade of B7-H1 suppresses the development of chronic intestinal inflammation
    Takanori Kanai
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Immunol 171:4156-63. 2003
    ....
  11. pmc Immune responses against a single CD8+-T-cell epitope induced by virus vector vaccination can successfully control Trypanosoma cruzi infection
    Yasushi Miyahira
    Atopy Research Center, Department of Parasitology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Infect Immun 73:7356-65. 2005
    ..cruzi. These results indicated, for the first time, that the induction of immune responses against a single CD8+-T-cell epitope derived from an intrinsic T. cruzi antigen was sufficient to control lethal T. cruzi infection...
  12. doi request reprint Expression and function of inducible costimulator on peripheral blood CD4+ T cells in Behçet's patients with uveitis: a new activity marker?
    Yoshihiko Usui
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:5099-104. 2010
    ..Inducible costimulator (ICOS) is an important costimulatory molecule involved in T-cell activation. In this study, the role of ICOS in the pathogenesis of uveitis in Behçet's disease (BD) was investigated...
  13. ncbi request reprint The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis
    Yoshihiko Usui
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    Eur J Immunol 36:3071-81. 2006
    ..We also indicated that ICOS-mediated costimulation plays differential roles in EAU and experimental autoimmune encephalomyelitis, which is also a Th1 disease induced in the same manner as EAU...
  14. ncbi request reprint Blockade of the OX40 ligand prolongs corneal allograft survival
    Takaaki Hattori
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Eur J Immunol 37:3597-604. 2007
    ..These results demonstrate that OX40L blockade is effective for prolongation of corneal allograft survival by inhibiting recipient T cell activation...
  15. ncbi request reprint Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells
    Teruji Totsuka
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Immunol 35:1773-85. 2005
    ..These results indicate that the CD4(+)CD25(-)PD-1(+) T cells contain substantial amounts of T(R) cells that are involved in the maintenance of peripheral tolerance...
  16. ncbi request reprint [Regulation of lymphocyte activation and function by cell surface molecules]
    Hisaya Akiba
    Department of Immunology, Juntendo University School of Medicine
    Nihon Rinsho 63:34-9. 2005
  17. ncbi request reprint Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis
    Hideyuki Iwai
    Department of Molecular Immunology, Tokyo Medical and Dental University, Tokyo, Japan
    J Immunol 171:2848-54. 2003
    ..Our results demonstrated the involvement of the ICOS-B7h costimulatory pathway in the pathogenesis of lupus nephritis, and the blockade of this pathway may be beneficial for the treatment of human systemic lupus erythematosus...
  18. ncbi request reprint Expression of programmed death 1 ligands by murine T cells and APC
    Tomohide Yamazaki
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Immunol 169:5538-45. 2002
    ..The inducible expression of PD-1 ligands on both T cells and APCs may suggest new paradigms of PD-1-mediated immune regulation...
  19. doi request reprint Premature terminal exhaustion of Friend virus-specific effector CD8+ T cells by rapid induction of multiple inhibitory receptors
    Shiki Takamura
    Department of Immunology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    J Immunol 184:4696-707. 2010
    ..These results highlight FV's unique ability to evade virus-specific CD8(+) T cell responses and the importance of an early prophylactic approach for preventing terminal exhaustion of CD8(+) T cells...
  20. ncbi request reprint OX40 ligand regulates splenic CD8(-) dendritic cell-induced Th2 responses in vivo
    Fumitaka Kamachi
    Department of Immunology, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 444:235-40. 2014
    ..Thus, OX40L on CD8(-) cDCs physiologically contributes to the development of Th2 cells and secondary Th2 responses induced by Ag-pulsed CD8(-) cDCs in vivo. ..
  21. ncbi request reprint Cutting edge: a potent adjuvant effect of ligand to receptor activator of NF-kappa B gene for inducing antigen-specific CD8+ T cell response by DNA and viral vector vaccination
    Yasushi Miyahira
    Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 171:6344-8. 2003
    ..Our results demonstrated, for the first time, the potent immunostimulatory effect of the RANK-L gene to improve the CD8(+) T cell-mediated immunity against infectious agents...
  22. pmc Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells
    Toshio Kawamoto
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Arthritis Res Ther 13:R47. 2011
    ..In this study, we investigated the effects of anti-TIM-2 monoclonal antibodies (mAbs) in collagen-induced arthritis (CIA) to determine whether TIM-2 contributes to the development of T helper (Th) 1 or Th17 cells and joint inflammation...
  23. pmc Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bukyou ku, Tokyo 113 8421, Japan
    J Exp Med 199:437-48. 2004
    ....
  24. doi request reprint TIM-1 signaling in B cells regulates antibody production
    Juan Ma
    Department of Immunology, Juntendo University, 2 1 1 Hongo, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 406:223-8. 2011
    ..These results suggest that TIM-1 signaling in B cells augments antibody production by enhancing B cell proliferation and differentiation...
  25. ncbi request reprint Roles of PU.1 in monocyte- and mast cell-specific gene regulation: PU.1 transactivates CIITA pIV in cooperation with IFN-gamma
    Tomonobu Ito
    Atopy Allergy Research Center, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Int Immunol 21:803-16. 2009
    ..1 transfectants indicate that enforced PU.1 suppresses mast cell-specific gene expression through these transcription factors...
  26. ncbi request reprint Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells
    Toshiro Futagawa
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Int Immunol 14:275-86. 2002
    ..Moreover, IL-12 production by anti-CD40-stimulated DC was partially inhibited by TKS-1. These results suggest that 4-1BB expressed on DC may be involved in DC activation through DC--tumor interaction and DC--DC interaction...
  27. ncbi request reprint ICOS costimulates invariant NKT cell activation
    Hiroshi Kaneda
    Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 327:201-7. 2005
    ..Moreover, blockade of both B7RP-1-ICOS and CD80/86-CD28 interactions mostly abolished the alpha-GalCer-induced immune responses. These findings indicate that iNKT cell activation is regulated by CD28 and IOCS independently...
  28. doi request reprint Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation
    Masafumi Nakayama
    Department of Immunology, Biomedical Research Center, Juntendo University School of Medicine, Tokyo, Japan
    Blood 113:3821-30. 2009
    ..These results indicate a crucial role for Tim-3 in phagocytosis of apoptotic cells and cross-presentation, which may be linked to peripheral tolerance...
  29. ncbi request reprint Blockade of CD70-CD27 interaction inhibits induction of allergic lung inflammation in mice
    Fumihiko Makino
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Am J Respir Cell Mol Biol 47:298-305. 2012
    ..These results indicate an important role for CD27 in the development of pathogenic Th2 cells in a murine model of allergic lung inflammation...
  30. ncbi request reprint TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bukyou ku, Tokyo 113 8421, Japan
    Blood 105:2082-9. 2005
    ..This study is the first to describe the concomitant maturation of NK cell effector function with surface phenotype in vivo and implies an important defense role for NK cell TRAIL in the developing immune system...
  31. ncbi request reprint Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody
    Seiji Kamijo
    Department of Immunology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Biochem Biophys Res Commun 347:124-32. 2006
    ..These results suggest the utility of anti-RANKL mAb for the prevention of osteoporosis associated with joint inflammation in RA...
  32. doi request reprint Wound-induced TGF-β1 and TGF-β2 enhance airway epithelial repair via HB-EGF and TGF-α
    Jun Ito
    Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 412:109-14. 2011
    ..These findings highlight an important collaborative mechanism between TGF-β and EGFR in maintaining airway epithelial homeostasis...
  33. doi request reprint Antibodies against B7-DC with differential binding properties exert opposite effects
    Patcharee Ritprajak
    Department of Molecular Immunology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Hybridoma (Larchmt) 31:40-7. 2012
    ..Our present results suggest that greater complexities of PD-1-mediated functions are induced via ligand binding for controlling immunity and tolerance...
  34. pmc Peritubular ischemia contributes more to tubular damage than proteinuria in immune-mediated glomerulonephritis
    Muh Geot Wong
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 1138421, Japan
    J Am Soc Nephrol 19:290-7. 2008
  35. doi request reprint T-cell immunoglobulin and mucin domain 3 acts as a negative regulator of atherosclerosis
    Amanda C Foks
    From the Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands A C F, I A R, L W, V F, M N D t B, S C A d J, P J v S, I B, J K, G H M v P Experimental Cardiology Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands S C A d J and Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan H Y, H A
    Arterioscler Thromb Vasc Biol 33:2558-65. 2013
    ..In the present study, we determined the role of Tim-3 in the development of atherosclerosis...
  36. pmc Galectin-9-mediated protection from allo-specific T cells as a mechanism of immune privilege of corneal allografts
    Machiko Shimmura-Tomita
    Department of Ophthalmology, Nippon Medical School, Tokyo, Japan
    PLoS ONE 8:e63620. 2013
    ..We propose that constitutive expression of Gal-9 plays an immunosuppressive role in corneal allografts. Gal-9 expressed on corneal endothelial cells protects them from destruction by allo-reactive T cells within the cornea...
  37. ncbi request reprint Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses
    Yuko Kikuchi
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 177:1609-17. 2006
    ..The findings have implications for sensitization to this relevant allergen in humans and for the design of modified allergen-vaccines for future allergen-specific immunotherapy...
  38. ncbi request reprint Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections
    Yasushi Miyahira
    Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, 113 8421, Tokyo, Japan
    Immunol Lett 89:193-9. 2003
    ..These results suggest the crucial role of this costimulatory pathway in the regulation of Th2-biased T cell differentiation and in host immune responses against L. major and N. brasiliensis infections...
  39. ncbi request reprint Association of the CD134/CD134L costimulatory pathway with acute rejection of small bowel allograft
    Lina Tian
    Division of Paediatric Surgery, Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, PR China
    Transplantation 74:133-8. 2002
    ..The CD134/CD134L pathway has been studied in inflammatory, autoimmune diseases, and graft-versus-host disease, but no information exists on the involvement of CD134/CD134L interactions in solid organ transplantation...
  40. ncbi request reprint Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients
    Bruce R Blazar
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis, MN, USA
    Blood 101:3741-8. 2003
    ..These data provide insights as to the mechanisms responsible for OX40/OX40L regulation of GVHD...
  41. ncbi request reprint Blockade of CD86 in BALB/c mice infected with Leishmania major does not prevent the expansion of low avidity T cells
    Monica Moro
    Centre National de la Recherche Scientifique, Valbonne, France
    Eur J Immunol 32:3566-75. 2002
    ..Taken together, our results suggest that the molecular interactions between CD28 on T cells and CD86 on APC serve to amplify and modulate T cell responses without promoting breadth in the TCR repertoire...
  42. ncbi request reprint Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulation
    Hideyuki Iwai
    Department of Molecular Immunology, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    J Immunol 169:4332-9. 2002
    ....
  43. ncbi request reprint B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism
    Koichiro Matsumoto
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 172:2530-41. 2004
    ..These results suggest a unique role for B7-DC in the regulation of asthmatic response through an IFN-gamma-dependent, but PD-1-independent, mechanism...
  44. ncbi request reprint Critical contribution of CD80 and CD86 to induction of anterior chamber-associated immune deviation
    Rintaro Tsukahara
    Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Int Immunol 17:523-30. 2005
    ..The present results indicated that CD80 and CD86 play a critical role in induction of ACAID, possibly by co-stimulating expansion and IL-10 production of regulatory T cells in response to TGF-beta-conditioned APC...
  45. ncbi request reprint The role of the CD134-CD134 ligand costimulatory pathway in alloimmune responses in vivo
    Xueli Yuan
    Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:2949-55. 2003
    ..Understanding the mechanisms of collaboration between these different pathways is important for the development of novel strategies to promote long-term allograft survival...
  46. pmc The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity
    Hiroshi Harada
    Department of Medicine, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 112:234-43. 2003
    ..These data define the complex functions of the ICOS-B7h pathway in regulating alloimmune responses in vivo...
  47. ncbi request reprint Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis
    Teruji Totsuka
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Japan
    Gastroenterology 124:410-21. 2003
    ..We investigated the involvement of the ICOS/B7RP-1 interaction in the pathogenesis of colitis and the therapeutic potential of anti-ICOS monoclonal antibody (mAb) in experimental colitis..
  48. ncbi request reprint Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease
    Tsunekazu Oikawa
    Department of Molecular Immunology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    J Immunol 177:4281-7. 2006
    ..Our results suggest that Tim-3 may play a crucial role in the regulation of CD8+ T cells responsible for the maintenance of hepatic homeostasis and tolerance...
  49. pmc Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis
    Alan D Salama
    Laboratory of Immunogenetics and Transplantation, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 198:71-8. 2003
    ..Interestingly, PD-L2 but not PD-L1 blockade in WT animals also resulted in disease augmentation. Our data are the first demonstration that the PD-1 pathway plays a critical role in regulating EAE...
  50. ncbi request reprint Antibodies to T-cell Ig and mucin domain-containing proteins (Tim)-1 and -3 suppress the induction and progression of murine allergic conjunctivitis
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Kohasu, Nankoku city 783 8505, Japan
    Biochem Biophys Res Commun 353:211-6. 2007
    ..Thus, treatment with anti-Tim-1 or anti-Tim-3 Ab can suppress both the induction and progression of EC, which could indicate potential preventive and/or therapeutic approaches for allergic diseases such as allergic conjunctivitis...
  51. ncbi request reprint T-cell Ig and mucin domain-containing protein (Tim)-2 regulates murine allergic conjunctivitis during the effector phase
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Oko cho, Nanhoku city, Japan
    Immunol Lett 110:133-8. 2007
    ..Thus, Tim-2 negatively regulates the Th2 differentiation of Ag-primed T-cells and the development of EC during the effector phase...
  52. pmc Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function
    Sheng Xiao
    Center for Neurologic Diseases, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 204:1691-702. 2007
    ..These data indicate that Tim-1 regulates T cell responses and that Tim-1 engagement can alter T cell function depending on the affinity/avidity with which it is engaged...
  53. pmc The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice
    Mohammed Javeed I Ansari
    Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 198:63-9. 2003
    ....
  54. ncbi request reprint B7-H3 regulates the development of experimental allergic conjunctivitis in mice
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Kohasu, Oko cho, Nankoku city 783 8505, Japan
    Immunol Lett 113:52-7. 2007
    ..Thus, regulation of EC by blocking of B7-H3 was observed during the induction phase but not the effector phase. Moreover, this study provides a new notion that B7-H3 regulates not only Th1-mediated but also Th2-mediated immune reactions...
  55. pmc OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation
    Shahram Salek-Ardakani
    La Jolla Institute for Allergy and Immunology, Division of Immunochemistry, 10355 Science Center Dr, San Diego, CA 92121, USA
    J Exp Med 198:315-24. 2003
    ..Thus, OX40-OX40L interactions are pivotal to the efficiency of recall responses regulated by memory Th2 cells...
  56. ncbi request reprint Roles of galectin-9 in the development of experimental allergic conjunctivitis in mice
    Atsuki Fukushima
    Department of Ophthalmology and Visual Science, Kochi Medical School, Nankoku, Japan fukushima kochi u ac jp
    Int Arch Allergy Immunol 146:36-43. 2008
    ..Here, we investigated whether administration of anti-galectin-9 antibodies (Abs) affects the development of murine experimental allergic conjunctivitis (EC), a Th2-mediated disease...
  57. pmc The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model
    Takuya Ueno
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 118:742-51. 2008
    ..These studies define previously unknown functions of TIM-1 in regulating alloimmune responses in vivo and may provide a novel approach to promoting transplantation tolerance...
  58. ncbi request reprint Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma
    Akihiko Hoshino
    Medicinal Research Laboratories, Taisho Pharmaceutical Co, Ltd, Saitama, Japan
    Eur J Immunol 33:861-9. 2003
    ..These results indicate a critical role for OX40L in the induction phase, which leads to the development of pathogenic Th2 cells, but not in the effector phase, which includes migration and activation of pathogenic Th2 cells in the lung...
  59. pmc TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells
    Susumu Nakae
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Blood 110:2565-8. 2007
    ..These observations suggest that TIM-1 and TIM-3 may be able to influence T-cell-mediated immune responses in part through effects on mast cells...