Research Topics
Genomes and Genes
| Hisaya AkibaSummaryAffiliation: Juntendo University School of Medicine Country: Japan Publications
| Collaborators
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Detail Information
Publications
The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivoHisaya Akiba
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
J Immunol 175:2340-8. 2005..These results indicated that the ICOS/B7RP-1 interaction plays an essential role in the development of CXCR5+ T(FH) cells in vivo...- Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responsesFumihiko Tsushima
Department of Molecular Immunology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Eur J Immunol 33:2773-82. 2003..Our results demonstrate the regulatory role of PD-1 and the differential roles of B7-H1 and B7-DC in hapten-induced immune responses. The PD-1-B7-H1 pathway may play a unique role in regulating inflammatory responses... - Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide productionTomohide Yamazaki
Department of Immunology, Juntendo University School of Medicine, Hongo, Tokyo, Japan
J Immunol 175:1586-92. 2005.... 
Contribution of B7RP-1/ICOS co-stimulation to lethal acute GVHDJunya Fujimura
Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
Pediatr Transplant 14:540-8. 2010....
IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2Tsuyoshi Ota
Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
Blood 106:184-92. 2005....- Eradication of established tumors in mice by a combination antibody-based therapyTomoyasu Uno
Department of Immunology, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421, Japan
Nat Med 12:693-8. 2006..These results in mice indicate that a rational monoclonal antibody-based therapy that both causes tumor-cell apoptosis through DR5 and activates T cells may be an effective strategy for cancer immunotherapy in humans... - B7-H3 contributes to the development of pathogenic Th2 cells in a murine model of asthmaOsamu Nagashima
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
J Immunol 181:4062-71. 2008..These results indicated an important role for B7-H3 in the development of pathogenic Th2 cells during the induction phase in a murine model of asthma... - Notch signaling confers antigen-presenting cell functions on mast cellsNobuhiro Nakano
Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
J Allergy Clin Immunol 123:74-81.e1. 2009..Notch signaling is involved in cell fate determination along with the development of the immune system. However, very little is known about the role for Notch signaling in mast cells... - Blockade of B7-H1 suppresses the development of chronic intestinal inflammationTakanori Kanai
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
J Immunol 171:4156-63. 2003.... - Immune responses against a single CD8+-T-cell epitope induced by virus vector vaccination can successfully control Trypanosoma cruzi infectionYasushi Miyahira
Atopy Research Center, Department of Parasitology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
Infect Immun 73:7356-65. 2005..cruzi. These results indicated, for the first time, that the induction of immune responses against a single CD8+-T-cell epitope derived from an intrinsic T. cruzi antigen was sufficient to control lethal T. cruzi infection... - The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitisYoshihiko Usui
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
Eur J Immunol 36:3071-81. 2006..We also indicated that ICOS-mediated costimulation plays differential roles in EAU and experimental autoimmune encephalomyelitis, which is also a Th1 disease induced in the same manner as EAU... - Blockade of the OX40 ligand prolongs corneal allograft survivalTakaaki Hattori
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Eur J Immunol 37:3597-604. 2007..These results demonstrate that OX40L blockade is effective for prolongation of corneal allograft survival by inhibiting recipient T cell activation... - Expression and function of inducible costimulator on peripheral blood CD4+ T cells in Behçet's patients with uveitis: a new activity marker?Yoshihiko Usui
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Invest Ophthalmol Vis Sci 51:5099-104. 2010..Inducible costimulator (ICOS) is an important costimulatory molecule involved in T-cell activation. In this study, the role of ICOS in the pathogenesis of uveitis in Behçet's disease (BD) was investigated... - Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cellsTeruji Totsuka
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Eur J Immunol 35:1773-85. 2005..These results indicate that the CD4(+)CD25(-)PD-1(+) T cells contain substantial amounts of T(R) cells that are involved in the maintenance of peripheral tolerance... - [Regulation of lymphocyte activation and function by cell surface molecules]Hisaya Akiba
Department of Immunology, Juntendo University School of Medicine
Nippon Rinsho 63:34-9. 2005 - Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritisHideyuki Iwai
Department of Molecular Immunology, Tokyo Medical and Dental University, Tokyo, Japan
J Immunol 171:2848-54. 2003..Our results demonstrated the involvement of the ICOS-B7h costimulatory pathway in the pathogenesis of lupus nephritis, and the blockade of this pathway may be beneficial for the treatment of human systemic lupus erythematosus... - Premature terminal exhaustion of Friend virus-specific effector CD8+ T cells by rapid induction of multiple inhibitory receptorsShiki Takamura
Department of Immunology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
J Immunol 184:4696-707. 2010..These results highlight FV's unique ability to evade virus-specific CD8(+) T cell responses and the importance of an early prophylactic approach for preventing terminal exhaustion of CD8(+) T cells... - Expression of programmed death 1 ligands by murine T cells and APCTomohide Yamazaki
Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
J Immunol 169:5538-45. 2002..The inducible expression of PD-1 ligands on both T cells and APCs may suggest new paradigms of PD-1-mediated immune regulation... - Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cellsToshio Kawamoto
Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
Arthritis Res Ther 13:R47. 2011..In this study, we investigated the effects of anti-TIM-2 monoclonal antibodies (mAbs) in collagen-induced arthritis (CIA) to determine whether TIM-2 contributes to the development of T helper (Th) 1 or Th17 cells and joint inflammation... - TIM-1 signaling in B cells regulates antibody productionJuan Ma
Department of Immunology, Juntendo University, 2 1 1 Hongo, Tokyo 113 8421, Japan
Biochem Biophys Res Commun 406:223-8. 2011..These results suggest that TIM-1 signaling in B cells augments antibody production by enhancing B cell proliferation and differentiation... - Induction of tumor-specific T cell immunity by anti-DR5 antibody therapyKazuyoshi Takeda
Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bukyou ku, Tokyo 113 8421, Japan
J Exp Med 199:437-48. 2004.... - Roles of PU.1 in monocyte- and mast cell-specific gene regulation: PU.1 transactivates CIITA pIV in cooperation with IFN-gammaTomonobu Ito
Atopy Allergy Research Center, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
Int Immunol 21:803-16. 2009..1 transfectants indicate that enforced PU.1 suppresses mast cell-specific gene expression through these transcription factors... - Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cellsToshiro Futagawa
Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
Int Immunol 14:275-86. 2002..Moreover, IL-12 production by anti-CD40-stimulated DC was partially inhibited by TKS-1. These results suggest that 4-1BB expressed on DC may be involved in DC activation through DC--tumor interaction and DC--DC interaction... - ICOS costimulates invariant NKT cell activationHiroshi Kaneda
Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
Biochem Biophys Res Commun 327:201-7. 2005..Moreover, blockade of both B7RP-1-ICOS and CD80/86-CD28 interactions mostly abolished the alpha-GalCer-induced immune responses. These findings indicate that iNKT cell activation is regulated by CD28 and IOCS independently... - Tim-3 mediates phagocytosis of apoptotic cells and cross-presentationMasafumi Nakayama
Department of Immunology, Biomedical Research Center, Juntendo University School of Medicine, Tokyo, Japan
Blood 113:3821-30. 2009..These results indicate a crucial role for Tim-3 in phagocytosis of apoptotic cells and cross-presentation, which may be linked to peripheral tolerance... - Blockade of CD70-CD27 interaction inhibits induction of allergic lung inflammation in miceFumihiko Makino
Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
Am J Respir Cell Mol Biol 47:298-305. 2012..These results indicate an important role for CD27 in the development of pathogenic Th2 cells in a murine model of allergic lung inflammation... - TRAIL identifies immature natural killer cells in newborn mice and adult mouse liverKazuyoshi Takeda
Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bukyou ku, Tokyo 113 8421, Japan
Blood 105:2082-9. 2005..This study is the first to describe the concomitant maturation of NK cell effector function with surface phenotype in vivo and implies an important defense role for NK cell TRAIL in the developing immune system... - Cutting edge: a potent adjuvant effect of ligand to receptor activator of NF-kappa B gene for inducing antigen-specific CD8+ T cell response by DNA and viral vector vaccinationYasushi Miyahira
Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo, Japan
J Immunol 171:6344-8. 2003..Our results demonstrated, for the first time, the potent immunostimulatory effect of the RANK-L gene to improve the CD8(+) T cell-mediated immunity against infectious agents... - Wound-induced TGF-β1 and TGF-β2 enhance airway epithelial repair via HB-EGF and TGF-αJun Ito
Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan
Biochem Biophys Res Commun 412:109-14. 2011..These findings highlight an important collaborative mechanism between TGF-β and EGFR in maintaining airway epithelial homeostasis... - Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibodySeiji Kamijo
Department of Immunology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
Biochem Biophys Res Commun 347:124-32. 2006..These results suggest the utility of anti-RANKL mAb for the prevention of osteoporosis associated with joint inflammation in RA... - Antibodies against B7-DC with differential binding properties exert opposite effectsPatcharee Ritprajak
Department of Molecular Immunology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Hybridoma (Larchmt) 31:40-7. 2012..Our present results suggest that greater complexities of PD-1-mediated functions are induced via ligand binding for controlling immunity and tolerance... - Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infectionsYasushi Miyahira
Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan
Immunol Lett 89:193-9. 2003..These results suggest the crucial role of this costimulatory pathway in the regulation of Th2-biased T cell differentiation and in host immune responses against L. major and N. brasiliensis infections... - Peritubular ischemia contributes more to tubular damage than proteinuria in immune-mediated glomerulonephritisMuh Geot Wong
Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1138421, Japan
J Am Soc Nephrol 19:290-7. 2008 - Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responsesYuko Kikuchi
Atopy (Allergy) Research Center, Juntendo University School of Medicine, Tokyo, Japan
J Immunol 177:1609-17. 2006..The findings have implications for sensitization to this relevant allergen in humans and for the design of modified allergen-vaccines for future allergen-specific immunotherapy... - The role of the CD134-CD134 ligand costimulatory pathway in alloimmune responses in vivoXueli Yuan
Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 170:2949-55. 2003..Understanding the mechanisms of collaboration between these different pathways is important for the development of novel strategies to promote long-term allograft survival... - Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthmaAkihiko Hoshino
Medicinal Research Laboratories, Taisho Pharmaceutical Co, Ltd, Saitama, Japan
Eur J Immunol 33:861-9. 2003..These results indicate a critical role for OX40L in the induction phase, which leads to the development of pathogenic Th2 cells, but not in the effector phase, which includes migration and activation of pathogenic Th2 cells in the lung... - Critical contribution of CD80 and CD86 to induction of anterior chamber-associated immune deviationRintaro Tsukahara
Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
Int Immunol 17:523-30. 2005..The present results indicated that CD80 and CD86 play a critical role in induction of ACAID, possibly by co-stimulating expansion and IL-10 production of regulatory T cells in response to TGF-beta-conditioned APC... - Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipientsBruce R Blazar
University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis, MN, USA
Blood 101:3741-8. 2003..These data provide insights as to the mechanisms responsible for OX40/OX40L regulation of GVHD... - Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitisTeruji Totsuka
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Japan
Gastroenterology 124:410-21. 2003..CONCLUSIONS: ICOS/B7RP-1 interactions are not required for the development of colitis. However, treatment with anti-ICOS mAb can prevent and reverse intestinal inflammation by inducing apoptosis of ICOS-expressing T lymphocytes... - Blockade of CD86 in BALB/c mice infected with Leishmania major does not prevent the expansion of low avidity T cellsMonica Moro
Centre National de la Recherche Scientifique, Valbonne, France
Eur J Immunol 32:3566-75. 2002..Taken together, our results suggest that the molecular interactions between CD28 on T cells and CD86 on APC serve to amplify and modulate T cell responses without promoting breadth in the TCR repertoire... - Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulationHideyuki Iwai
Department of Molecular Immunology, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
J Immunol 169:4332-9. 2002.... - Association of the CD134/CD134L costimulatory pathway with acute rejection of small bowel allograftLina Tian
Division of Paediatric Surgery, Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, PR China
Transplantation 74:133-8. 2002..The CD134/CD134L pathway has been studied in inflammatory, autoimmune diseases, and graft-versus-host disease, but no information exists on the involvement of CD134/CD134L interactions in solid organ transplantation... - The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) miceMohammed Javeed I Ansari
Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Boston, MA 02115, USA
J Exp Med 198:63-9. 2003.... - Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitisAlan D Salama
Laboratory of Immunogenetics and Transplantation, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 198:71-8. 2003..Interestingly, PD-L2 but not PD-L1 blockade in WT animals also resulted in disease augmentation. Our data are the first demonstration that the PD-1 pathway plays a critical role in regulating EAE... - OX40 (CD134) controls memory T helper 2 cells that drive lung inflammationShahram Salek-Ardakani
La Jolla Institute for Allergy and Immunology, Division of Immunochemistry, 10355 Science Center Dr, San Diego, CA 92121, USA
J Exp Med 198:315-24. 2003..Thus, OX40-OX40L interactions are pivotal to the efficiency of recall responses regulated by memory Th2 cells... - B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanismKoichiro Matsumoto
Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Immunol 172:2530-41. 2004..These results suggest a unique role for B7-DC in the regulation of asthmatic response through an IFN-gamma-dependent, but PD-1-independent, mechanism... - Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host diseaseTsunekazu Oikawa
Department of Molecular Immunology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
J Immunol 177:4281-7. 2006..Our results suggest that Tim-3 may play a crucial role in the regulation of CD8+ T cells responsible for the maintenance of hepatic homeostasis and tolerance... - Antibodies to T-cell Ig and mucin domain-containing proteins (Tim)-1 and -3 suppress the induction and progression of murine allergic conjunctivitisAtsuki Fukushima
Department of Ophthalmology and Visual Science, Kochi Medical School, Kohasu, Nankoku city 783 8505, Japan
Biochem Biophys Res Commun 353:211-6. 2007..Thus, treatment with anti-Tim-1 or anti-Tim-3 Ab can suppress both the induction and progression of EC, which could indicate potential preventive and/or therapeutic approaches for allergic diseases such as allergic conjunctivitis... - T-cell Ig and mucin domain-containing protein (Tim)-2 regulates murine allergic conjunctivitis during the effector phaseAtsuki Fukushima
Department of Ophthalmology and Visual Science, Kochi Medical School, Oko cho, Nanhoku city, Japan
Immunol Lett 110:133-8. 2007..Thus, Tim-2 negatively regulates the Th2 differentiation of Ag-primed T-cells and the development of EC during the effector phase... - Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector functionSheng Xiao
Center for Neurologic Diseases, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 204:1691-702. 2007..These data indicate that Tim-1 regulates T cell responses and that Tim-1 engagement can alter T cell function depending on the affinity/avidity with which it is engaged... - B7-H3 regulates the development of experimental allergic conjunctivitis in miceAtsuki Fukushima
Department of Ophthalmology and Visual Science, Kochi Medical School, Kohasu, Oko cho, Nankoku city 783 8505, Japan
Immunol Lett 113:52-7. 2007..Thus, regulation of EC by blocking of B7-H3 was observed during the induction phase but not the effector phase. Moreover, this study provides a new notion that B7-H3 regulates not only Th1-mediated but also Th2-mediated immune reactions... - The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunityHiroshi Harada
Department of Medicine, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 112:234-43. 2003..These data define the complex functions of the ICOS-B7h pathway in regulating alloimmune responses in vivo... - Roles of galectin-9 in the development of experimental allergic conjunctivitis in miceAtsuki Fukushima
Department of Ophthalmology and Visual Science, Kochi Medical School, Nankoku, Japan fukushima kochi u ac jp
Int Arch Allergy Immunol 146:36-43. 2008..Here, we investigated whether administration of anti-galectin-9 antibodies (Abs) affects the development of murine experimental allergic conjunctivitis (EC), a Th2-mediated disease... - The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant modelTakuya Ueno
Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 118:742-51. 2008..These studies define previously unknown functions of TIM-1 in regulating alloimmune responses in vivo and may provide a novel approach to promoting transplantation tolerance... - TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cellsSusumu Nakae
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
Blood 110:2565-8. 2007..These observations suggest that TIM-1 and TIM-3 may be able to influence T-cell-mediated immune responses in part through effects on mast cells...