Hiroshi Yoshida

Summary

Affiliation: Jikei University School of Medicine
Country: Japan

Publications

  1. doi request reprint Effects of pitavastatin and atorvastatin on lipoprotein oxidation biomarkers in patients with dyslipidemia
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Chiba, Japan Department of General Medicine, Jikei University Kashiwa Hospital, Chiba, Japan
    Atherosclerosis 226:161-4. 2013
  2. doi request reprint Estimation of lipoprotein profile in patients with type II diabetes and its relevance to remnant lipoprotein cholesterol levels
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, 163 1 Kashiwashita Kashiwa, Chiba 277 8567, Japan
    Atherosclerosis 222:541-4. 2012
  3. ncbi request reprint [Triglyceride (TG) and remnant lipoproteins]
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Kashiwa 277 8567, Japan
    Rinsho Byori 60:343-8. 2012
  4. ncbi request reprint [Clinical significance of lipoprotein analysis method by HPLC]
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Jikei University School of Medicine, Kashiwa 277 8567, Japan
    Rinsho Byori 58:1093-8. 2010
  5. doi request reprint Sex differences in effects of valsartan administration on cardiovascular outcomes in hypertensive patients: findings from the Jikei Heart Study
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Kashiwa, Chiba, Japan
    J Hypertens 28:1150-7. 2010
  6. ncbi request reprint [Front line of oxidized lipoproteins: role of oxidized lipoproteins in atherogenesis and cardiovascular disease risk]
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Kashiwa 277 8567, Japan
    Rinsho Byori 58:622-30. 2010
  7. ncbi request reprint Effects of supervised aerobic exercise training on serum adiponectin and parameters of lipid and glucose metabolism in subjects with moderate dyslipidemia
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Kashiwa, Chiba, Japan
    J Atheroscler Thromb 17:1160-6. 2010
  8. pmc Characteristic comparison of triglyceride-rich remnant lipoprotein measurement between a new homogenous assay (RemL-C) and a conventional immunoseparation method (RLP-C)
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Japan
    Lipids Health Dis 7:18. 2008
  9. doi request reprint Mechanisms of LDL oxidation
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Chiba, Japan
    Clin Chim Acta 411:1875-82. 2010
  10. ncbi request reprint Increased serum iron may contribute to enhanced oxidation of low-density lipoprotein in smokers in part through changes in lipoxygenase and catalase
    Hiroshi Yoshida
    Department of General Medicine, Jikei University School of Medicine, Chiba, Japan
    Clin Chim Acta 345:161-70. 2004

Detail Information

Publications95

  1. doi request reprint Effects of pitavastatin and atorvastatin on lipoprotein oxidation biomarkers in patients with dyslipidemia
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Chiba, Japan Department of General Medicine, Jikei University Kashiwa Hospital, Chiba, Japan
    Atherosclerosis 226:161-4. 2013
    ..The effects of potent statins on oxidized lipoprotein biomarkers are not well defined...
  2. doi request reprint Estimation of lipoprotein profile in patients with type II diabetes and its relevance to remnant lipoprotein cholesterol levels
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, 163 1 Kashiwashita Kashiwa, Chiba 277 8567, Japan
    Atherosclerosis 222:541-4. 2012
    ..Remnant lipoprotein (RLP), associated with atherosclerosis progression, is often elevated in diabetes mellitus. The RLP level is estimated by immune-separation method and agarose-gel electrophoresis (AGE)...
  3. ncbi request reprint [Triglyceride (TG) and remnant lipoproteins]
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Kashiwa 277 8567, Japan
    Rinsho Byori 60:343-8. 2012
    ....
  4. ncbi request reprint [Clinical significance of lipoprotein analysis method by HPLC]
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Jikei University School of Medicine, Kashiwa 277 8567, Japan
    Rinsho Byori 58:1093-8. 2010
    ....
  5. doi request reprint Sex differences in effects of valsartan administration on cardiovascular outcomes in hypertensive patients: findings from the Jikei Heart Study
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Kashiwa, Chiba, Japan
    J Hypertens 28:1150-7. 2010
    ..This substudy analyses the sex difference in cardiovascular disease risk reduction in the Jikei Heart Study...
  6. ncbi request reprint [Front line of oxidized lipoproteins: role of oxidized lipoproteins in atherogenesis and cardiovascular disease risk]
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Kashiwa 277 8567, Japan
    Rinsho Byori 58:622-30. 2010
    ..Taken together, we have to keep an open mind regarding the incompletely understood pathogenesis in association with oxidized lipoproteins...
  7. ncbi request reprint Effects of supervised aerobic exercise training on serum adiponectin and parameters of lipid and glucose metabolism in subjects with moderate dyslipidemia
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Kashiwa, Chiba, Japan
    J Atheroscler Thromb 17:1160-6. 2010
    ..To examine the effects of supervised aerobic exercise training on serum adiponectin and lipids, including triglyceride (TG)-rich lipoproteins, in moderate dyslipidemic subjects...
  8. pmc Characteristic comparison of triglyceride-rich remnant lipoprotein measurement between a new homogenous assay (RemL-C) and a conventional immunoseparation method (RLP-C)
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Japan
    Lipids Health Dis 7:18. 2008
    ....
  9. doi request reprint Mechanisms of LDL oxidation
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Chiba, Japan
    Clin Chim Acta 411:1875-82. 2010
    ..This review summarizes a diversity of mechanisms proposed for LDL oxidation serving for the so-called "LDL oxidation hypothesis of atherogenesis"...
  10. ncbi request reprint Increased serum iron may contribute to enhanced oxidation of low-density lipoprotein in smokers in part through changes in lipoxygenase and catalase
    Hiroshi Yoshida
    Department of General Medicine, Jikei University School of Medicine, Chiba, Japan
    Clin Chim Acta 345:161-70. 2004
    ..Increased oxidative stress is considered to be causative for cardiovascular disease (CVD) in smokers, but its mechanisms are still unclear. We compared oxidative stress markers between male smokers and male nonsmokers...
  11. ncbi request reprint Gender differences in the effects of angiotensin receptor blockers on cardiovascular disease
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Chiba, Japan
    Curr Pharm Des 17:1090-4. 2011
    ....
  12. ncbi request reprint [Medical safety management in the blood collection center of clinical laboratory]
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Kashiwa 277 8567, Japan
    Rinsho Byori 59:293-8. 2011
    ....
  13. ncbi request reprint Implications of decreased serum adiponectin for type IIb hyperlipidaemia and increased cholesterol levels of very-low-density lipoprotein in type II diabetic patients
    Hiroshi Yoshida
    Division of General Medicine, Department of Internal Medicine, Kashiwa Hospital, Jikei University School of Medicine, Chiba 277 856, Japan
    Clin Sci (Lond) 109:297-302. 2005
    ..Measuring VLDL-cholesterol may be helpful for understanding the pathological features of diabetic dyslipidaemia...
  14. ncbi request reprint Edaravone, a novel radical scavenger, inhibits oxidative modification of low-density lipoprotein (LDL) and reverses oxidized LDL-mediated reduction in the expression of endothelial nitric oxide synthase
    Hiroshi Yoshida
    Division of General Medicine, Department of Internal Medicine, Kashiwa Hospital, Jikei University School of Medicine, 163 1 Kashiwashita, Kashiwa, Chiba 277 8567, Japan
    Atherosclerosis 179:97-102. 2005
    ..The preventive action of edaravone from ischemic disease consequence may be attributed to these eNOS up-regulation with decreased oxidation...
  15. ncbi request reprint Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury
    Hiroshi Yoshida
    Department of Internal Medicine, Division of General Medicine, Kashiwa Hospital, Jikei University School of Medicine, Kashiwa, Chiba, Japan
    CNS Drug Rev 12:9-20. 2006
    ..The combination therapy (a thrombolytic plus edaravone) is likely to target brain edema, reduce stroke death and improve the recovery from neurological deficits in stoke patients...
  16. doi request reprint Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Chiba, Japan
    Atherosclerosis 209:520-3. 2010
    ..Astaxanthin has been reported to improve dyslipidemia and metabolic syndrome in animals, but such effects in humans are not well known...
  17. doi request reprint Expression of nestin mRNA is a differentiation marker in thyroid tumors
    Hiroya Yamada
    Department of Laboratory Medicine, Osaka University Medical School, 2 2 D2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Cancer Lett 280:61-4. 2009
    ..These results suggest that nestin mRNA is a differentiation marker, and its expression does not relate to malignant characteristics in thyroid tumors...
  18. ncbi request reprint Expression of oncofetal fibronectin mRNA in thyroid anaplastic carcinoma
    Toru Takano
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan
    Jpn J Clin Oncol 37:647-51. 2007
    ..Its expression in anaplastic thyroid carcinoma (ATC), however, has not been clarified, since only a few cases had been examined in previous studies...
  19. doi request reprint Effects of diacylglycerol on glucose, lipid metabolism, and plasma serotonin levels in lean Japanese
    Hidekatsu Yanai
    Department of Internal Medicine, The Jikei University School of Medicine, Chiba, Japan
    Obesity (Silver Spring) 16:47-51. 2008
    ..Further, to reveal the mechanism for increased EE by DAG, we measured plasma serotonin, which is mostly present in the small intestine and mediates peripheral sympathetic thermogenesis...
  20. ncbi request reprint [Therapeutic application of diacylglycerol oil for the metabolic syndrome]
    Hidekatsu Yanai
    Department of Internal Medicine, International Medical Center of Japan Kohnodai Hospital, Ichikawa, Chiba 272 8516, Japan
    Rinsho Byori 58:39-44. 2010
    ..Our studies presented DAG-mediated amelioration in postprandial TG-rich lipoprotein, insulin, and energy metabolism, indicating the therapeutic application of DAG for the metabolic syndrome...
  21. ncbi request reprint Decreased relative expression level of trefoil factor 3 mRNA to galectin-3 mRNA distinguishes thyroid follicular carcinoma from adenoma
    Toru Takano
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, D2, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Cancer Lett 219:91-6. 2005
    ..72; 95% CI, 0.49-0.95). Quantification of the T/G ratio may be a useful tool for the distinction between follicular adenomas and carcinomas, which is the most difficult in thyroid pathology...
  22. doi request reprint Preparation of thyroid tumor cells in aspiration biopsies for aspiration biopsy nucleic acid diagnosis
    Toru Takano
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, D2, 2 2 Yamadaoka, Osaka 565 0871, Suita, Japan
    Head Neck 30:983-90. 2008
    ..However, because of the interference by the simultaneously aspirated peripheral blood cells or infiltrating lymphocytes, the precise measurement of the T/G ratio in aspirates is difficult...
  23. ncbi request reprint Measurement of TFF3 mRNA in aspirates from thyroid nodules using mesh filtration: the first clinical trial in 130 cases
    Hiroya Yamada
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Endocr J 59:621-30. 2012
    ..However, one nodule diagnosed as follicular adenoma after surgery showed a high T/G ratio. Our present method may be a promising preoperative test for measuring mRNAs in thyroid aspirates...
  24. pmc Diacylglycerol oil for the metabolic syndrome
    Hidekatsu Yanai
    Department of Internal Medicine, The Jikei University School of Medicine, Chiba, Japan
    Nutr J 6:43. 2007
    ..Further, the therapeutic application of DAG for the metabolic syndrome will be considered...
  25. pmc The underlying mechanisms for development of hypertension in the metabolic syndrome
    Hidekatsu Yanai
    Department of Internal Medicine, The Jikei University School of Medicine, Chiba, Japan
    Nutr J 7:10. 2008
    ..Here, we will discuss how these factors influence on development of hypertension in the metabolic syndrome...
  26. ncbi request reprint Detection of monoclonality of the immunoglobulin heavy chain gene in thyroid malignant lymphoma by vectorette polymerase chain reaction
    Toru Takano
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Clin Endocrinol Metab 90:720-3. 2005
    ..3%) malignant lymphomas. These results suggest that vectorette PCR may be a substitute for SBH, and because it requires only a small volume of samples, it may be used in the analysis of aspiration biopsies...
  27. ncbi request reprint Quantitative measurement of telomerase reverse transcriptase, thyroglobulin and thyroid transcription factor 1 mRNAs in anaplastic thyroid carcinoma tissues and cell lines
    Toru Takano
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Oncol Rep 18:715-20. 2007
    ..This information could contribute to clarifying the nature of ATCs and could be useful in detecting TSCs, which have not yet been identified...
  28. ncbi request reprint Ubiquitous expression of galectin-3 mRNA in benign and malignant thyroid tumors
    Toru Takano
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, D2, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Cancer Lett 199:69-73. 2003
    ....
  29. doi request reprint Preparation of thyroid follicular cells for mRNA quantification after fluorescence-activated cell sorting
    Chisa Matsumoto
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Scand J Clin Lab Invest 73:245-52. 2013
    ..These findings imply that preparation of thyroid cells using the present method is suitable for FACS-mQ analysis...
  30. ncbi request reprint [Relevance of lipoprotein cholesterol levels measured by HPLC method to appearance midband on electrophoresis and remnant-like particle (RLP)-cholesterol levels]
    Hideo Kurosawa
    Clinical Laboratory, Kashiwa Hospital, The Jikei University School of Medicine, Kashiwa
    Rinsho Byori 52:737-41. 2004
    ..In conclusion, this novel HPLC method can provide valuable information for analyses on TG-rich lipoproteins...
  31. ncbi request reprint Aspiration biopsy-nucleic acid diagnosis of thyroid malignant lymphoma by vectorette PCR: experience of eight cases
    Toru Takano
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, D2, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Leuk Res 32:151-4. 2008
    ..ABND using VR is a useful adjunct of aspiration biopsy cytology in the diagnosis of thyroid malignant lymphoma...
  32. ncbi request reprint Comparative study between anion-exchange HPLC and homogeneous assay methods in regard to the accuracy of high- and low-density lipoprotein cholesterol measurement
    Hideo Kurosawa
    Department of Laboratory Medicine, Jikei University Hospital, Japan
    Clin Biochem 40:1291-6. 2007
    ..The present study was performed to compare this HPLC method to homogenous assay in regard to measurement accuracy of HDL and LDL cholesterol...
  33. doi request reprint Genes that characterize T3-predominant Graves' thyroid tissues
    Chisa Matsumoto
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, D2, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Eur J Endocrinol 168:137-44. 2013
    ..The aim of our study is to identify genes that characterize T(3)-predominant Graves' disease tissue in order to clarify the molecular mechanism of this disease...
  34. ncbi request reprint Expression of TRbeta1 mRNAs with functionally impaired mutations is rare in thyroid papillary carcinoma
    Toru Takano
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    J Clin Endocrinol Metab 88:3447-9. 2003
    ..Our findings suggest that the expression of functionally impaired mutants in papillary carcinomas is rare, and they raise a question about the possible role of mutated TRbeta1 in the tumorigenesis of papillary carcinoma...
  35. ncbi request reprint Thrombospondin 1 mRNA as a candidate for a marker to detect thyroid-derived fibroblasts in fine needle aspiration biopsy of the thyroid
    Toru Takano
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Endocr J 53:197-202. 2006
    ..These results suggest that TSP-1 mRNA is a possible marker for contamination of thyroid-derived fibroblasts...
  36. ncbi request reprint Effects of diacylglycerol ingestion on postprandial hyperlipidemia in diabetes
    Norio Tada
    Department of Internal Medicine, Division of General Medicine, Kashiwa Hospital, The Jikei University School of Medicine, 163 1 Kashiwashita, Kashiwa, Chiba 277 8567, Japan
    Clin Chim Acta 353:87-94. 2005
    ..This study was to investigate the effects of DAG on postprandial lipids, particularly remnant lipoproteins in diabetics...
  37. ncbi request reprint [Environmental factors associated with the onset of lipid metabolism disorders]
    Hidekatsu Yanai
    Division of General Medicine, Department of Internal Medicine, The Jikei University School of Medicine, Kashiwa Hospital
    Nihon Rinsho 65:136-40. 2007
  38. pmc Clinical, radiological, and biochemical characteristics in patients with diseases mimicking polymyalgia rheumatica
    Hidekatsu Yanai
    Division of General Medicine, Department of Internal Medicine, The Jikei University School of Medicine, Kashiwa, Japan
    Clin Interv Aging 4:391-5. 2009
    ..Pitting edema of the back of hands and symmetric gallium uptake in MCP joints are characteristic for RS3PE syndrome...
  39. pmc A molecular mechanism for diacylglycerol-mediated promotion of negative caloric balance
    Hidekatsu Yanai
    Department of Internal Medicine, Jikei University School of Medicine, Chiba, Japan
    Diabetes Metab Syndr Obes 3:1-6. 2010
    ..We studied the molecular mechanisms for DAG-mediated increase in serotonin and EE...
  40. doi request reprint A novel magnetic crystal-lipid nanostructure for magnetically guided in vivo gene delivery
    Yoshihisa Namiki
    Institute of Clinical Medicine and Research, The Jikei University School of Medicine, 163 1 Kashiwa shita, Kashiwa, Chiba, Japan
    Nat Nanotechnol 4:598-606. 2009
    ..By delivering an optimized sequence of a silencing RNA that targets the epidermal growth factor receptor of tumour vessels, the intended therapeutic benefit was achieved with no evident adverse immune reaction or untoward side effects...
  41. ncbi request reprint The possible contribution of a general glycosphingolipid transporter, GM2 activator protein, to atherosclerosis
    Hidekatsu Yanai
    Division of General Medicine, Department of Internal Medicine, Kashiwa Hospital, The Jikei University School of Medicine, Chiba, Japan
    J Atheroscler Thromb 13:281-5. 2006
    ..Collectively, elevated levels of GM2 activator protein in the aorta may be another feature of human atherosclerosis...
  42. ncbi request reprint [Draft proposal to estimate true values of serum potassium in samples from patients with myeloproliferative neoplasma]
    Kotaro Hishiki
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Kashiwa 277 8567, Japan
    Rinsho Byori 60:516-22. 2012
    ....
  43. doi request reprint Endothelin-1 prolongs intracellular calcium transient decay in neonatal rat cardiac myocytes
    Yoshiki Uehara
    Division of Cardiology, Department of Internal Medicine, The Jikei University Kashiwa Hospital, 163 1, Kashiwashita, Kashiwa, Chiba, 277 8567, Japan
    Heart Vessels 27:98-105. 2012
    ..Specific inhibition of the ETA receptor may be a possible therapeutic strategy for improving cardiac performance...
  44. pmc Myositis, Vasculitis, Hepatic Dysfunction in Adult-Onset Still's Disease
    Hidekatsu Yanai
    Division of General Medicine, Department of Internal Medicine, The Jikei University School of Medicine, 163 1, Kashiwashita, Kashiwa, Chiba 277 8567, Japan
    Case Report Med 2009:504897. 2009
    ....
  45. ncbi request reprint [Clinical significance of triglyceride-rich lipoproteins in metabolic syndrome]
    Norio Tada
    Division of General Medicine, Department of Internal Medicine, Kashiwa Hospital, The Jikei University School of Medicine, Kashiwa 277 8567
    Rinsho Byori 55:439-46. 2007
    ..Statins, fibrates, nicotinic acid derivatives, and EPA are the drugs recommended for the treatment of dyslipidemias in metabolic syndrome...
  46. ncbi request reprint Preclinical study of a "tailor-made" combination of NK4-expressing gene therapy and gefitinib (ZD1839, Iressa) for disseminated peritoneal scirrhous gastric cancer
    Yoshihisa Namiki
    Institute of Clinical Medicine and Research, The Jikei University School of Medicine, Kashiwa, Chiba, Japan
    Int J Cancer 118:1545-55. 2006
    ..0001) and time to euthanasia (days) (control, 36.5; treated, 56; p < 0.0001) were also significantly prolonged. This combination is a potentially useful approach to the treatment of peritoneal gefitinib-sensitive SGC dissemination...
  47. pmc A teenager with abdominal pain and soft-tissue emphysema
    Hidekatsu Yanai
    Department of Emergency Medicine, Jikei University School of Medicine, Kashiwa, Japan
    CMAJ 174:624. 2006
  48. ncbi request reprint Decreased expression of catalase mRNA in thyroid anaplastic carcinoma
    Yukiko Hasegawa
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Jpn J Clin Oncol 33:6-9. 2003
    ..A decreased expression of glutathione peroxidase mRNA, an antioxidant enzyme, was previously observed in thyroid anaplastic carcinomas...
  49. doi request reprint The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis
    Wataru Nogami
    Division of Hematology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Haematologica 93:1495-504. 2008
    ..The aim of this study was to identify an orally bioavailable human Mpl activator that does not develop autoantibodies against endogenous thrombopoietin...
  50. ncbi request reprint Pharmacological preconditioning with bradykinin affords myocardial protection through NO-dependent mechanisms
    Hiroshi Yoshida
    Department of Internal Medicine, Nippon Medical School, Tama Nagayama Hospital, Tama shi, Tokyo, Japan
    Int Heart J 46:877-87. 2005
    ..BK affords myocardial protection in the early phase of pharmacological preconditioning through a pathway that includes endogenous NO, PKC, and mitochondrial K(ATP) channels...
  51. ncbi request reprint Hepatocyte growth factor and cardiovascular thrombosis in patients admitted to the intensive care unit
    Noritake Hata
    Department of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan
    Circ J 68:645-9. 2004
    ..The aim of this study was to investigate this relationship in patients with chest pain...
  52. ncbi request reprint Diacylglycerol on lipid metabolism
    Norio Tada
    Department of General Medicine, Jikei University School of Medicine, Chiba, Japan
    Curr Opin Lipidol 14:29-33. 2003
    ..This review summarizes recent research in humans and experimental animals into the metabolic effects and possible mechanisms of action of this oil...
  53. ncbi request reprint Decreased expression of glutathione peroxidase mRNA in thyroid anaplastic carcinoma
    Yukiko Hasegawa
    Department of Laboratory Medicine, Osaka University Medical School, D2, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Cancer Lett 182:69-74. 2002
    ..A molecular-based therapy which produces O(2) radical may be considered as an alternative choice for the treatment of anaplastic carcinomas...
  54. ncbi request reprint Acanthosis nigricans is a reliable cutaneous marker of insulin resistance in obese Japanese children
    Hajime Yamazaki
    Department of Pediatrics, Tsuruoka City Shonai Hospital, Tsuruoka, Japan
    Pediatr Int 45:701-5. 2003
    ..Recently, AN has been reported to be linked to hyperinsulinemia and obesity. The aim of the present study was to determine whether or not the presence of AN in obese Japanese children is a reliable cutaneous marker...
  55. ncbi request reprint Measurement of cholesterol of major serum lipoprotein classes by anion-exchange HPLC with perchlorate ion-containing eluent
    Yuji Hirowatari
    Scientific Instruments Division, TOSOH Corp, 2743 1 Hayakawa Ayase shi, Kanagawa 252 1123, Japan
    J Lipid Res 44:1404-12. 2003
    ..883 and r = 0.729, respectively). This rapid and accurate HPLC method was successfully applied to the analysis of plasma lipoproteins of patients with hyperlipidemia...
  56. ncbi request reprint Analysis method for lipoproteins by high-performance liquid chromatography with sulfopropyl-ligand column and magnesium ion-containing eluents
    Yuji Hirowatari
    Scientific Instruments Division, TOSOH Corp, Kanagawa, Japan
    Anal Biochem 308:336-42. 2002
    ..940, 0.979, and 0.909, respectively. The new method was successfully applied to the analysis of plasma lipoproteins of patients with hyperlipidemia...
  57. ncbi request reprint Sweet elements of Siraitia grosvenori inhibit oxidative modification of low-density lipoprotein
    Eiichiro Takeo
    First Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    J Atheroscler Thromb 9:114-20. 2002
    ..These results demonstrate that SG extract can inhibit LDL oxidation and that 11-Oxo-mog.V, a sweet element of SG extract, provides the anti-oxidative property of SG which might reduce the atherogenic potential of LDL...
  58. ncbi request reprint Clustering of components of the metabolic syndrome and risk for development of type 2 diabetes in Japanese male office workers
    Noriyuki Nakanishi
    Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine F2, 2 2 Yamada oka, Suita Shi, 565 0871 Osaka, Japan
    Diabetes Res Clin Pract 63:185-94. 2004
    ..1-6.9 mmol/l). These results indicate that clustering of components of the MS associated with diabetes precedes an increase in the risk of type 2 diabetes in Japanese men...
  59. ncbi request reprint Effects of losartan and its combination with quinapril on the cardiac sympathetic nervous system and neurohormonal status in essential hypertension
    Kazuyuki Sakata
    Department of Nuclear Medicine, Shizuoka General Hospital, 4 27 1 Kita andou, Shizuoka, Japan
    J Hypertens 20:103-10. 2002
    ..This study was aimed at assessing the effects of losartan or its combination with quinapril on the cardiac nervous system and neurohormonal status in essential hypertension...
  60. ncbi request reprint Components of the metabolic syndrome as predictors of cardiovascular disease and type 2 diabetes in middle-aged Japanese men
    Noriyuki Nakanishi
    Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, 2 2 Yamada oka, Suita Shi, Osaka 565 0871, Japan
    Diabetes Res Clin Pract 64:59-70. 2004
    ..001 for all). Our findings indicate that clustered features of the metabolic syndrome are closely associated with development of CVD and type 2 diabetes in middle-aged Japanese...
  61. ncbi request reprint [Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (2001). II. Background of patients]
    Yoshiaki Kumamoto
    Department of Urology, Sapporo Medical University, School of Medicine
    Jpn J Antibiot 56:424-36. 2003
    ..was frequently isolated in the patients with surgery. In complicated UTIs with indwelling catheter, S. aureus and Staphylococcus spp. were frequently isolated in the patients without surgery...
  62. ncbi request reprint [Education of clinical laboratory medicine in the premedical course of Fukushima Medical University]
    Hiroshi Yoshida
    Department of Clinical Laboratory Medicine, Fukushima Medical University School of Medicine, Fukushima 960 1247
    Rinsho Byori 51:1150-3. 2003
    ....
  63. ncbi request reprint Central retinal artery Doppler flow parameters reflect the severity of cerebral small-vessel disease
    Masahiko Hiroki
    Human Brain Research Center, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Stroke 34:e92-4. 2003
    ..We investigated the usefulness of central retinal artery (CRA) Doppler flowmetry in patients with cerebral small-vessel disease (SVD)...
  64. ncbi request reprint Proton therapy for head and neck malignancies at Tsukuba
    Koichi Tokuuye
    Department of Radiation Oncology, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan
    Strahlenther Onkol 180:96-101. 2004
    ..To evaluate the effectiveness and feasibility of proton therapy for head and neck cancers...
  65. ncbi request reprint Glycine ameliorates lung reperfusion injury after cold preservation in an ex vivo rat lung model
    Mitsugu Omasa
    Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transplantation 75:591-8. 2003
    ..The role of glycine has not been investigated in lung ischemia-reperfusion injury after cold preservation. Furthermore, the role of apoptosis after reperfusion following cold preservation has not been fully understood...
  66. ncbi request reprint Evaluation of indexes of in vivo manganese status and the optimal intravenous dose for adult patients undergoing home parenteral nutrition
    Yoji Takagi
    Department of Maternity and Child Nursing, The School of Allied Health Sciences, Faculty of Medicine, Osaka University, Japan
    Am J Clin Nutr 75:112-8. 2002
    ..There are no accurate indexes for determining the status of manganese in humans, and there is no clear recommended daily dose of this essential trace element to be administered in total parenteral nutrition solutions...
  67. ncbi request reprint Characterization of autofluorescence in oral squamous cell carcinoma
    Kojiro Onizawa
    Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Oral Oncol 39:150-6. 2003
    ..These results suggest that the autofluorescence in oral SCC correlates with the progression of lesions, and that fluorescent substances such as protoporphyrin are produced in association with the cancerous tissue...
  68. ncbi request reprint [Microbiology--laboratory examinations for bacterias]
    Renjun Hen
    Department of Clinical Laboratory Medicine, Fukushima Medical University, Fukushima 960 1247
    Rinsho Byori 50:1041-6. 2002
    ..The test was shown to be highly sensitive and specific. For the rapid identification of pathogenic microbes, simple and rapid test kits described here will be used more in clinical diagnosis...
  69. ncbi request reprint Comparison of the effectiveness of ET-Kyoto with Euro-Collins and University of Wisconsin solutions in cold renal storage
    Hiroshi Yoshida
    Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transplantation 74:1231-6. 2002
    ..In this study, the efficacy of ETKS for renal cold storage compared with Euro-Collins solution (ECS) and University of Wisconsin solution (UWS) was investigated...
  70. ncbi request reprint BMI and gastroesophageal reflux in women
    Hidekatsu Yanai
    N Engl J Med 355:848-9; author reply 849-50. 2006
  71. ncbi request reprint Cerebrospinal fluid tau in dementia disorders: a large scale multicenter study by a Japanese study group
    Mikio Shoji
    Department of Neurology, Division of Neuroscience Biophysical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Neurobiol Aging 23:363-70. 2002
    ..Measurement of CSF tau was useful as a biomarker for early and differential diagnosis of AD...
  72. ncbi request reprint The effect of EDTA contaminated in sera on laboratory data
    Yuji Imafuku
    Department of Clinical Laboratory Medicine, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1247, Japan
    Clin Chim Acta 325:105-11. 2002
    ..One of the mechanisms was suspected to be due to the backflow of evacuated blood mixed with K(2)EDTA into serum tube...
  73. ncbi request reprint First isolation of Bartonella henselae type I from a cat-scratch disease patient in Japan and its molecular analysis
    Soichi Maruyama
    Laboratory of Veterinary Public Health, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Kanagawa, Japan
    Microbiol Immunol 48:103-9. 2004
    ..We found two different genomic profiles. These results suggest that the patient had been either co-infected or re-infected with two genetically different strains of B. henselae...
  74. ncbi request reprint [Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (2001). III. Secular changes in susceptibility]
    Yoshiaki Kumamoto
    Department of Urology, Sapporo Medical University, School of Medicine
    Jpn J Antibiot 56:584-673. 2003
    ..Although the drug sensitivity of P. aeruginosa was generally low, the detection of the strains that showed good susceptibility to quinolones and carbapenems (MIC: < or = 0.125-2 micrograms/mL) were relatively frequent...
  75. ncbi request reprint Presence of immunounreactive albumin in the urine of diabetic patients
    Aki Nakayama
    Analytical Laboratory Chemistry, Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    J Clin Lab Anal 20:29-36. 2006
    ..Furthermore, the albumin concentrations analyzed by Native PAGE were higher than SDS PAGE in 61 (76.2%) of 80 samples. This study suggests the need for evaluating diabetes not only by HPLC, but also by combining it with another method...
  76. ncbi request reprint [Hypertriglyceridemia]
    Hiroshi Yoshida
    Department of Laboratory Medicine, The Jikei University School of Medicine Kashiwa Hospital
    Nihon Rinsho 64:378-84. 2006
  77. ncbi request reprint Polo-like kinase 1 expression in medullary carcinoma of the thyroid: its relationship with clinicopathological features
    Yasuhiro Ito
    Kuma Hospital, Kobe, and Department of Pathology, Wakayama Medical University, Japan
    Pathobiology 72:186-90. 2005
    ..However, its protein expression in human carcinoma has not been studied in depth. In this study, we investigated PLK1 expression in medullary thyroid carcinoma by means of immunohistochemistry...
  78. ncbi request reprint [Findings obtained by the analyses of unexpected abnormal laboratory data]
    Hiroshi Yoshida
    Kita Fukushima Medical Center, Date
    Rinsho Byori 55:45-9. 2007
    ..Every issue examined is practically important, and laboratory staffs including physicians should pay more attention on the unexpected laboratory data and know why and how the data are produced...
  79. ncbi request reprint Oxidized low density lipoprotein elevates platelet serotonin release
    Hidekatsu Yanai
    Am J Hematol 82:686-7. 2007
  80. ncbi request reprint [Standardization and issues of rheumatoid factor measurement]
    Yuji Imafuku
    Department of Clinical Laboratory Medicine, Fukushima Medical University School of Medicine, Fukushima
    Rinsho Byori 54:853-60. 2006
    ..To disclose the current situation of rheumatoid factor (RF) measurement in Japan...
  81. ncbi request reprint Hypoadiponectinemia in lean lactating women: Prolactin inhibits adiponectin secretion from human adipocytes
    Mikiko Asai-Sato
    Department of Obstetrics, Gynecology and Molecular Reproductive Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Endocr J 53:555-62. 2006
    ..Our results thus suggests that prolactin affects the regulation of maternal metabolism through suppression of adiponectin...
  82. ncbi request reprint Tissue Prx I in the protection against Fe-NTA and the reduction of nitroxyl radicals
    Junya Uwayama
    Biomolecular and Integrated Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 339:226-31. 2006
    ..These results demonstrate that Prx I-/- mice have less reducing activity and are more susceptible to the damage mediated by reactive oxygen species in vivo than wild-type mice...
  83. ncbi request reprint [From the perspective of a clinical laboratory physician]
    Hiroshi Yoshida
    Department of Clinical Laboratory Medicine, Fukushima Medical University School of Medicine, Fukushima 960 1247
    Rinsho Byori 53:1155-8. 2005
    ..Laboratory physicians and technologists should pay more attention to laboratory tests being performed by examinees and outpatients themselves, and participate more in improving and evaluating the usefulness of these tests...
  84. pmc The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma
    Takayuki Harada
    Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Clin Invest 117:1763-70. 2007
    ..We believe these mice are the first animal models of NTG that offer a powerful system for investigating mechanisms of neurodegeneration in NTG and developing therapies directed at IOP-independent mechanisms of RGC loss...
  85. ncbi request reprint Transgenic over-expression of GATA-1 mutant lacking N-finger domain causes hemolytic syndrome in mouse erythroid cells
    Mayu Nakano
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305 8577, Japan
    Genes Cells 10:47-62. 2005
    ..These data provide the first in vivo evidence that the NF domain contributes to the gene regulation that is critical for differentiation and survival of mature RBCs in postnatal erythropoiesis...
  86. ncbi request reprint [One-year experience of Men's Outpatient Health Care Unit without specifying the category of disease]
    Hiroshi Yoshida
    Department of Urology, Kyoto City Hospital
    Hinyokika Kiyo 54:267-71. 2008
    ..Our experience of this health care system suggested that male-specific gender medicine should become more widespread and cover various categories of diseases...
  87. ncbi request reprint Neuroprotective effect of geranylgeranylacetone against ischemia-induced retinal injury
    Chikako Harada
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    Mol Vis 13:1601-7. 2007
    ..This study was conducted to assess the effects of geranylgeranylacetone (GGA) on ischemia-induced retinal injury...
  88. ncbi request reprint [Nationwide surveillance of parenteral antibiotics containing meropenem activities against clinically isolated strains in 2002]
    Keizo Yamaguchi
    Department of Microbiology, Toho University School of Medicine
    Jpn J Antibiot 57:70-104. 2004
    ..In conclusion, the results from this surveillance study suggest that MEPM retains its potent and broad antibacterial activity and therefore is a clinically useful carbapenem; at present, 7 years after available for commercial use...
  89. ncbi request reprint [Histological view of ethics in medicine and handling of residual samples in clinical laboratories]
    Hiroshi Yoshida
    Department of Clinical Laboratory Medicine, Fukushima Medical University School of Medicine, Fukushima 960 1247
    Rinsho Byori 52:231-5. 2004
    ..The background and discussion for the proposal and the current situation on how to obtain consent from patients in Japan are mentioned...
  90. ncbi request reprint [For the improvement of management and assurance in clinical laboratories of education hospitals--from the meeting of clinical laboratory members of public university or college hospitals]
    Hiroshi Yoshida
    Department of Clinical Laboratories, Fukushima Medical University Hospital, Fukushima 960 1247
    Rinsho Byori 52:242-4. 2004
    ..Information obtained through discussion could help in the determination of management and the improvement of education and quality assurance in clinical laboratories...
  91. ncbi request reprint A multi-institutional retrospective analysis of external radiotherapy for mucosal melanoma of the head and neck in Northern Japan
    Hitoshi Wada
    Northern Japanese Radiation Therapy Oncology Group, Department of Radiology, Yamagata City Hospital, Yamagata, Japan
    Int J Radiat Oncol Biol Phys 59:495-500. 2004
    ..A multi-institutional retrospective study was performed in northern Japan to analyze the outcome of external radiotherapy as the definitive treatment modality for localized mucosal melanoma of the head and neck...
  92. ncbi request reprint [Preanalytical issues]
    Yuji Imafuku
    Department of Clinical Laboratory Medicine, Fukushima Medical University School of Medicine, Fukushima 960 1247
    Rinsho Byori 55:936-41. 2007
    ..We also report a case of abnormal results of creatinine clearance (Ccr) caused by the urine collection apparatus as an example of preanalytical issue...
  93. ncbi request reprint Molecular targeting of antiangiogenic factor 16K hPRL inhibits oxygen-induced retinopathy in mice
    Hao Pan
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, USA
    Invest Ophthalmol Vis Sci 45:2413-9. 2004
    ..To examine the ability and mechanism of the 16 kDa N-terminal fragment of human prolactin (16K hPRL) in the inhibition of abnormal retinal neovascularization...
  94. ncbi request reprint Nrf2 deficiency causes tooth decolourization due to iron transport disorder in enamel organ
    Toru Yanagawa
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
    Genes Cells 9:641-51. 2004
    ..Our results thus demonstrate that the enamel organ of Nrf2-deficient mouse has a reduced iron transport capacity, which results in both the enamel cell degeneration and disturbance of iron deposition on to the enamel surface...
  95. ncbi request reprint [Nationwide surveillance of parenteral antibiotics containing meropenem activities against clinically isolated strains in 2004]
    Keizo Yamaguchi
    Department of Microbiology and Infectious Diseases, Toho University School of Medicine
    Jpn J Antibiot 58:655-89. 2005
    ..In conclusion, the results from this surveillance study suggest that MEPM retains its potent and broad antibacterial activity and therefore is a clinically useful carbapenem at present, 9 years after available for commercial use...