Research Topics
Genomes and Genes | Naohiro WatanabeSummaryAffiliation: Jikei University School of Medicine Country: Japan Publications
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Publications
The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralisNaohiro Watanabe
Department of Tropical Medicine, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
Int Immunopharmacol 4:367-75. 2004..The effects of the non-impairing, H(1)-receptor antagonist fexofenadine were investigated in in vivo mouse models of eosinophilia and systemic anaphylaxis...- Th2 immune responses in GATA-3-transgenic mice infected with Heligmosomoides polygyrusNaohiro Watanabe
Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan
Int Arch Allergy Immunol 131:11-4. 2003..These results suggest that GATA-3 promotes IL-5 and IL-13 production, and that the function of these cytokines results in eosinophilia and hyper-IgE, respectively... - IgE: a question of protective immunity in Trichinella spiralis infectionNaohiro Watanabe
Department of Tropical Medicine, Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minatoku, Tokyo 105 8461, Japan
Trends Parasitol 21:175-8. 2005..In this article, we focus on IgE in Trichinella spiralis infection in rodents and humans, and discuss the possible roles of IgE in protection and pathogenesis... - Immune responses to Nippostrongylus brasiliensis and tuberculin protein in GATA-3-transgenic miceHideyuki Ozawa
Department of Tropical Medicine, Jikei University School of Medicine, Minatoku, Tokyo, Japan
Immunol Lett 99:228-35. 2005..However, IL-4 production was not significantly elevated in GATA-3-Tg mice, indicating that IL-4 and IL-5 production was differentially regulated in these mice... - Chymase inhibitor ameliorates eosinophilia in mice infected with Nippostrongylus brasiliensisNaohiro Watanabe
Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan
Int Arch Allergy Immunol 128:235-9. 2002..CONCLUSIONS: Chymase released by activated mast cells may play a role in helminth-induced eosinophilia... 
Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensisKenji Ishiwata
Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan
J Immunol 184:2086-94. 2010..brasiliensis infection...- Mast cell-mediated immune responses through IgE antibody and Toll-like receptor 4 by malarial peroxiredoxinTakahisa Furuta
Division of Infectious Genetics, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Eur J Immunol 38:1341-50. 2008.... 
Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticksTakeshi Wada
Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
J Clin Invest 120:2867-75. 2010....- Cloning and expression of cDNA for interleukin 4 from the MSKR inbred strain of Mus musculus molossinusHiroko Ikeshima-Kataoka
Department of Molecular Immunology, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
In Vivo 23:277-80. 2009..In MSKR, IL-4 was expressed at high levels in thymus and spleen as revealed by reverse transcriptase PCR method and Northern hybridization. The tissue-specific expression profile was quite similar to that of laboratory mice... - Nippostrongylus brasiliensis: reversibility of reduced-energy status associated with the course of expulsion from the small intestine in ratsKenji Ishiwata
Department of Tropical Medicine, The Jikei University School of Medicine, 3 25 8, Nishi Shinbashi, Minato ku, Tokyo 105 8461, Japan
Exp Parasitol 117:80-6. 2007..Short in vitro culture of adult worms under low oxygen tension resulted in low ATP value in the worms. These results suggested that adult worms were dislodged from their preferred site by intact energy metabolism activity... - Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infectionsYasushi Miyahira
Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan
Immunol Lett 89:193-9. 2003..These results suggest the crucial role of this costimulatory pathway in the regulation of Th2-biased T cell differentiation and in host immune responses against L. major and N. brasiliensis infections... - Chymase inhibitor improves dermatitis in NC/Nga miceNaohiro Watanabe
Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan
Int Arch Allergy Immunol 128:229-34. 2002..CONCLUSION: Mast cell chymase may contribute to the pathogenesis of AD, and SUN-C8257 will be beneficial to the treatment of the skin disorder... - Association of mast cell-derived VEGF and proteases in Dengue shock syndromeTakahisa Furuta
Division of Infectious Genetics, Institute of Medical Science, University of Tokyo, Tokyo, Japan
PLoS Negl Trop Dis 6:e1505. 2012.... - Rat monoclonal anti-murine IgE antibody removes IgE molecules already bound to mast cells or basophilic leukemia cells, resulting in the inhibition of systemic anaphylaxis and passive cutaneous anaphylaxisHiroaki Miyajima
Division of Pathobiology, Juntendo University School of Medicine, Jikei University School of Medicine, Tokyo, Japan
Int Arch Allergy Immunol 128:24-32. 2002..In summary, anti-IgE antibodies can remove IgE antibodies from the FcepsilonRI; anti-IgE/IgE complexes can be detected in vitro and in vivo, and anti-IgE antibodies can inhibit IgE-mediated systemic or local anaphylactic reactions... - Elevated levels of vascular endothelial growth factor (VEGF) and soluble vascular endothelial growth factor receptor (VEGFR)-2 in human malariaTakahisa Furuta
Division of Infectious Genetics, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Am J Trop Med Hyg 82:136-9. 2010..This is the first report to suggest that the interaction of VEGF and sVEGFR-2 is involved in the host immune response to malarial infection and that malarial parasites induce VEGF secretion from human mast cells... - Basophils are essential initiators of a novel type of chronic allergic inflammationKazushige Obata
Department of Immune Regulation, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Blood 110:913-20. 2007..Thus, basophils play a pivotal role in the development of IgE-mediated chronic allergic inflammation, as an initiator rather than as an effector... - Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosisTakahisa Furuta
Division of Infectious Genetics, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Int Immunol 18:1655-62. 2006..gondii ME49. These results suggest that the small intestine plays an important role in the induction of innate immunity in naturally acquired toxoplasmosis... - [Allergy in parasitic infections]Naohiro Watanabe
Department of Tropical Medicine, The Jikei University School of Medicine
Nippon Rinsho 63:517-20. 2005 - Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammationYouichi Shibata
Department of Molecular Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
J Immunol 169:2134-40. 2002..Thus, the level of Ras activation in T cells appears to determine Th2-dependent eosinophilic inflammation and Ag-induced airway hyperresponsiveness... - Protective roles of mast cells and mast cell-derived TNF in murine malariaTakahisa Furuta
Department of Microbiology and Immunology, Division of Infectious Genetics, University of Tokyo, Japan
J Immunol 177:3294-302. 2006..These findings propose a novel mechanism that mast cells and mast cell-derived TNF play protective roles in malaria...