Naohiro Watanabe

Summary

Affiliation: Jikei University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Impaired protection against Trichinella spiralis in mice with high levels of IgE
    Naohiro Watanabe
    Department of Allergology, The Jikei University School of Medicine, Japan Department of Allergology, The Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan Electronic address
    Parasitol Int 63:332-6. 2014
  2. ncbi request reprint Th2 immune responses in GATA-3-transgenic mice infected with Heligmosomoides polygyrus
    Naohiro Watanabe
    Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 131:11-4. 2003
  3. ncbi request reprint The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis
    Naohiro Watanabe
    Department of Tropical Medicine, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    Int Immunopharmacol 4:367-75. 2004
  4. ncbi request reprint IgE: a question of protective immunity in Trichinella spiralis infection
    Naohiro Watanabe
    Department of Tropical Medicine, Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minatoku, Tokyo 105 8461, Japan
    Trends Parasitol 21:175-8. 2005
  5. ncbi request reprint Immune responses to Nippostrongylus brasiliensis and tuberculin protein in GATA-3-transgenic mice
    Hideyuki Ozawa
    Department of Tropical Medicine, Jikei University School of Medicine, Minatoku, Tokyo, Japan
    Immunol Lett 99:228-35. 2005
  6. ncbi request reprint Chymase inhibitor ameliorates eosinophilia in mice infected with Nippostrongylus brasiliensis
    Naohiro Watanabe
    Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 128:235-9. 2002
  7. doi request reprint Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis
    Kenji Ishiwata
    Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan
    J Immunol 184:2086-94. 2010
  8. doi request reprint Mast cell-mediated immune responses through IgE antibody and Toll-like receptor 4 by malarial peroxiredoxin
    Takahisa Furuta
    Division of Infectious Genetics, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Eur J Immunol 38:1341-50. 2008
  9. ncbi request reprint [Allergy in parasitic infections]
    Naohiro Watanabe
    Department of Tropical Medicine, The Jikei University School of Medicine
    Nihon Rinsho 63:517-20. 2005
  10. pmc Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks
    Takeshi Wada
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Clin Invest 120:2867-75. 2010

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Impaired protection against Trichinella spiralis in mice with high levels of IgE
    Naohiro Watanabe
    Department of Allergology, The Jikei University School of Medicine, Japan Department of Allergology, The Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan Electronic address
    Parasitol Int 63:332-6. 2014
    ..In addition, the impaired protection was found in IgE high-responder mice but not in low-responder mice, suggesting that protection against T. spiralis is controlled by IgE responsiveness in the host. ..
  2. ncbi request reprint Th2 immune responses in GATA-3-transgenic mice infected with Heligmosomoides polygyrus
    Naohiro Watanabe
    Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 131:11-4. 2003
    ..These results suggest that GATA-3 promotes IL-5 and IL-13 production, and that the function of these cytokines results in eosinophilia and hyper-IgE, respectively...
  3. ncbi request reprint The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis
    Naohiro Watanabe
    Department of Tropical Medicine, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    Int Immunopharmacol 4:367-75. 2004
    ..The effects of the non-impairing, H(1)-receptor antagonist fexofenadine were investigated in in vivo mouse models of eosinophilia and systemic anaphylaxis...
  4. ncbi request reprint IgE: a question of protective immunity in Trichinella spiralis infection
    Naohiro Watanabe
    Department of Tropical Medicine, Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minatoku, Tokyo 105 8461, Japan
    Trends Parasitol 21:175-8. 2005
    ..In this article, we focus on IgE in Trichinella spiralis infection in rodents and humans, and discuss the possible roles of IgE in protection and pathogenesis...
  5. ncbi request reprint Immune responses to Nippostrongylus brasiliensis and tuberculin protein in GATA-3-transgenic mice
    Hideyuki Ozawa
    Department of Tropical Medicine, Jikei University School of Medicine, Minatoku, Tokyo, Japan
    Immunol Lett 99:228-35. 2005
    ..However, IL-4 production was not significantly elevated in GATA-3-Tg mice, indicating that IL-4 and IL-5 production was differentially regulated in these mice...
  6. ncbi request reprint Chymase inhibitor ameliorates eosinophilia in mice infected with Nippostrongylus brasiliensis
    Naohiro Watanabe
    Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 128:235-9. 2002
    ..Infection with helminth parasites is known to increase the level of mast cell chymase in the jejunum and serum in mice. The aim of the present study is to elucidate the role of chymase in helminth infection...
  7. doi request reprint Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis
    Kenji Ishiwata
    Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan
    J Immunol 184:2086-94. 2010
    ..brasiliensis infection...
  8. doi request reprint Mast cell-mediated immune responses through IgE antibody and Toll-like receptor 4 by malarial peroxiredoxin
    Takahisa Furuta
    Division of Infectious Genetics, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Eur J Immunol 38:1341-50. 2008
    ....
  9. ncbi request reprint [Allergy in parasitic infections]
    Naohiro Watanabe
    Department of Tropical Medicine, The Jikei University School of Medicine
    Nihon Rinsho 63:517-20. 2005
  10. pmc Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks
    Takeshi Wada
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Clin Invest 120:2867-75. 2010
    ....
  11. ncbi request reprint Cloning and expression of cDNA for interleukin 4 from the MSKR inbred strain of Mus musculus molossinus
    Hiroko Ikeshima-Kataoka
    Department of Molecular Immunology, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    In Vivo 23:277-80. 2009
    ..In MSKR, IL-4 was expressed at high levels in thymus and spleen as revealed by reverse transcriptase PCR method and Northern hybridization. The tissue-specific expression profile was quite similar to that of laboratory mice...
  12. ncbi request reprint Nippostrongylus brasiliensis: reversibility of reduced-energy status associated with the course of expulsion from the small intestine in rats
    Kenji Ishiwata
    Department of Tropical Medicine, The Jikei University School of Medicine, 3 25 8, Nishi Shinbashi, Minato ku, Tokyo 105 8461, Japan
    Exp Parasitol 117:80-6. 2007
    ..Short in vitro culture of adult worms under low oxygen tension resulted in low ATP value in the worms. These results suggested that adult worms were dislodged from their preferred site by intact energy metabolism activity...
  13. ncbi request reprint Chymase inhibitor improves dermatitis in NC/Nga mice
    Naohiro Watanabe
    Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 128:229-34. 2002
    ..To elucidate the possible role of chymase in AD, we examined the effect of a chymase inhibitor on skin lesions of NC/Nga mice...
  14. ncbi request reprint Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis
    Takahisa Furuta
    Division of Infectious Genetics, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 18:1655-62. 2006
    ..gondii ME49. These results suggest that the small intestine plays an important role in the induction of innate immunity in naturally acquired toxoplasmosis...
  15. ncbi request reprint Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections
    Yasushi Miyahira
    Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, 113 8421, Tokyo, Japan
    Immunol Lett 89:193-9. 2003
    ..These results suggest the crucial role of this costimulatory pathway in the regulation of Th2-biased T cell differentiation and in host immune responses against L. major and N. brasiliensis infections...
  16. pmc Association of mast cell-derived VEGF and proteases in Dengue shock syndrome
    Takahisa Furuta
    Division of Infectious Genetics, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    PLoS Negl Trop Dis 6:e1505. 2012
    ....
  17. ncbi request reprint Rat monoclonal anti-murine IgE antibody removes IgE molecules already bound to mast cells or basophilic leukemia cells, resulting in the inhibition of systemic anaphylaxis and passive cutaneous anaphylaxis
    Hiroaki Miyajima
    Division of Pathobiology, Juntendo University School of Medicine, Jikei University School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 128:24-32. 2002
    ..In summary, anti-IgE antibodies can remove IgE antibodies from the FcepsilonRI; anti-IgE/IgE complexes can be detected in vitro and in vivo, and anti-IgE antibodies can inhibit IgE-mediated systemic or local anaphylactic reactions...
  18. pmc Elevated levels of vascular endothelial growth factor (VEGF) and soluble vascular endothelial growth factor receptor (VEGFR)-2 in human malaria
    Takahisa Furuta
    Division of Infectious Genetics, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Am J Trop Med Hyg 82:136-9. 2010
    ..This is the first report to suggest that the interaction of VEGF and sVEGFR-2 is involved in the host immune response to malarial infection and that malarial parasites induce VEGF secretion from human mast cells...
  19. ncbi request reprint Basophils are essential initiators of a novel type of chronic allergic inflammation
    Kazushige Obata
    Department of Immune Regulation, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Blood 110:913-20. 2007
    ..Thus, basophils play a pivotal role in the development of IgE-mediated chronic allergic inflammation, as an initiator rather than as an effector...
  20. ncbi request reprint Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation
    Youichi Shibata
    Department of Molecular Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Immunol 169:2134-40. 2002
    ..Thus, the level of Ras activation in T cells appears to determine Th2-dependent eosinophilic inflammation and Ag-induced airway hyperresponsiveness...
  21. ncbi request reprint Protective roles of mast cells and mast cell-derived TNF in murine malaria
    Takahisa Furuta
    Department of Microbiology and Immunology, Division of Infectious Genetics, University of Tokyo, Japan
    J Immunol 177:3294-302. 2006
    ..These findings propose a novel mechanism that mast cells and mast cell-derived TNF play protective roles in malaria...