Research Topics
| Mitsuyoshi UrashimaSummaryAffiliation: Jikei University School of Medicine Country: Japan Publications
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Detail Information
Publications
A seasonal model to simulate influenza oscillation in TokyoMitsuyoshi Urashima
Department of Pediatrics, Jikei University School of Medicine, Tokyo 105 8461, Japan
Jpn J Infect Dis 56:43-7. 2003..These results suggest that most of the oscillation in the number of influenza cases may be explained using a seasonal model that can simulate the impact of global warming...
Verocytotoxin-producing Escherichia coli, Japan, 1999-2004Mio Sakuma
Jikei University School of Medicine, Tokyo, Japan
Emerg Infect Dis 12:323-5. 2006..The annual incidence was 2.74/100,000 population; its fluctuation over time and space was associated with climate, socioeconomic, and population factors...
Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildrenMitsuyoshi Urashima
Division of Molecular Epidemiology, Jikei University School of Medicine, Nishi Shimbashi 3 25 8, Minato ku, Tokyo 105 8461, Japan
Am J Clin Nutr 91:1255-60. 2010..To our knowledge, no rigorously designed clinical trials have evaluated the relation between vitamin D and physician-diagnosed seasonal influenza...
MDM2 protein overexpression inhibits apoptosis of TF-1 granulocyte-macrophage colony-stimulating factor-dependent acute myeloblastic leukemia cellsM Urashima
Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan
Blood 92:959-67. 1998..These results suggest that GM-CSF-independent growth of AML cells is associated with overexpression of MDM2 protein and related modulation of p53 expression...
Seasonal models of herpangina and hand-foot-mouth disease to simulate annual fluctuations in urban warming in TokyoMitsuyoshi Urashima
Department of Pediatrics, Jikei University School of Medicine, Tokyo 105 8461, Japan
Jpn J Infect Dis 56:48-53. 2003..These results suggest that our seasonal models may quantify the dependency of infectious diseases on seasonal parameters and simulate the impact of global warming...
Gene expression profiles of peripheral and cord blood mononuclear cells altered by thymic stromal lymphopoietinMitsuyoshi Urashima
Division of Clinical Research and Development, Jikei University School of Medicine, Tokyo, Japan
Pediatr Res 57:563-9. 2005..These results suggest that the advent of microarray technology may enable us to screen novel molecular targets to treat TSLP-related allergic inflammation...
Functional mutation analysis of EGFR family genes and corresponding lymph node metastases in head and neck squamous cell carcinomaTakanori Hama
Division of Molecular Epidemiology, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo 105 8461, Japan
Clin Exp Metastasis 29:19-25. 2012..These results contribute to our understanding of the genetic basis of drug sensitivity and will help design drugs that specifically target different subtypes of HNSCC...
25-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's diseaseMasahiko Suzuki
Department of Neurology, Jikei University School of Medicine, Tokyo, Japan
Mov Disord 27:264-71. 2012..However, significant associations were not observed in 1,25-hydroxyvitamin D levels...
Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinomaTakanori Hama
Division of Molecular Epidemiology, Jikei University School of Medicine, Minato ku, Tokyo, Japan
Oncologist 14:900-8. 2009..In conclusion, phosphorylated EGFR without mutations may be a marker of poor prognosis in patients with HNSCC...
Gastric ulcer after laparoscopic fundoplication for gastroesophageal reflux disease: significance of the eradication of Helicobacter pyloriNobuo Omura
Department of Surgery, Jikei University School of Medicine, Minato ku, Tokyo, Japan
Surg Laparosc Endosc Percutan Tech 17:193-6. 2007..The eradication of H. pylori may be an effective therapeutic means to prevent gastric ulcers recurrence after fundoplication...
Increased synthesis of indoleamine-2,3-dioxygenase protein is positively associated with impaired survival in patients with serous-type, but not with other types of, ovarian cancerMiho Takao
Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo 105 8461, Japan
Oncol Rep 17:1333-9. 2007..These results suggested that the increased synthesis of IDO protein was positively associated with impaired survival only in the serous type of ovarian cancer...
Cardiac sympathetic denervation in bradykinesia-dominant Parkinson's diseaseMasahiko Suzuki
Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan
Neuroreport 18:1867-70. 2007..Our results suggest a close link between myocardial sympathetic degeneration and bradykinesia, age at onset and disease duration...
The odor stick identification test for Japanese differentiates Parkinson's disease from multiple system atrophy and progressive supra nuclear palsyMasahiko Suzuki
Department of Neurology, Aoto Hospital, Jikei University School of Medicine, 6 41 2 Aoto Katsushika ku, Tokyo 125 8506, Japan
BMC Neurol 11:157. 2011..There is no information on the sensitivity and specificity of OSIT-J in the diagnosis of parkinsonian syndromes such as PSP and MSA-P...
Prognostic significance of vitamin D receptor polymorphisms in head and neck squamous cell carcinomaTakanori Hama
Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan
PLoS ONE 6:e29634. 2011..We hypothesized that a similar association would be observed in patients with head and neck squamous-cell carcinoma (HNSCC)...
Establishment of an immortalized human extravillous trophoblast cell line by retroviral infection of E6/E7/hTERT and its transcriptional profile during hypoxia and reoxygenationHiroko Omi
Department of Obstetrics and Gynecology, The Jikei University, School of Medicine, Tokyo, Japan
Int J Mol Med 23:229-36. 2009..Forty-three genes showing reversible up- or down-regulation during hypoxia were detected using an oligonucleotide array. This newly immortalized cell line, HChEpC1b, is a useful model for the study of extravillous trophoblast function...
Laparoscopic Collis gastroplasty and Nissen fundoplication for reflux esophagitis with shortened esophagus in Japanese patientsKazuto Tsuboi
Department of Surgery, Jikei University School of Medicine, Minato ku, Tokyo, Japan
Surg Laparosc Endosc Percutan Tech 16:401-5. 2006..There is an extremely small number of surgical cases of laparoscopic Collis gastroplasty and Nissen fundoplication (LCN procedure) in Japan, and it is a fact that the surgical results are not thoroughly examined...
Interactions between serum vitamin D levels and vitamin D receptor gene FokI polymorphisms for renal function in patients with type 2 diabetesKeitaro Yokoyama
Division of Kidney, Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
PLoS ONE 7:e51171. 2012....
Indoleamine 2,3-dioxygenase serves as a marker of poor prognosis in gene expression profiles of serous ovarian cancer cellsAikou Okamoto
Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan
Clin Cancer Res 11:6030-9. 2005..CONCLUSION: The indoleamine 2,3-dioxygenase screened with the GeneChip was positively associated with paclitaxel resistance and with impaired survival in patients with serous-type ovarian cancer...
Copy number amplification of the PIK3CA gene is associated with poor prognosis in non-lymph node metastatic head and neck squamous cell carcinomaToshihito Suda
Department of Oto Rhino Laryngology, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, 105 8461, Japan
BMC Cancer 12:416. 2012....
Physical and socioeconomic predictors of birthweight in JapanSatoshi Teramoto
Department of Pediatrics, The Jikei University School of Medicine, Kashiwa shi, Chiba, Japan
Pediatr Int 48:274-7. 2006..The purpose of this study was to characterize physical and socioeconomic factors associated with birthweight in Tokyo, Japan...
Effect of gelatinization on gastric emptying and absorptionNaruo Kawasaki
Department of Surgery, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
Hepatogastroenterology 55:1843-5. 2008..The aim of this study was to compare the gastric emptying and absorption obtained by 13C-breath test after ingestion of liquid or gelatinized liquid nutrients...
The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer riskMitsuru Kaise
Department of Gastroenterology, Toranomon Hospital, 2 2 2 Toranomon, Minato ku, Tokyo 105 8470, Japan
J Gastroenterol 46:736-45. 2011..Although pepsinogen (PG) testing has been introduced as a predictor, its predictive power is not satisfactory. We examined whether serum trefoil factor (TFF) could be a non-endoscopic predictor of the presence of gastric cancer...
Bisphosphonate incadronate prevents total gastrectomy-induced osteopenia in ratsYutaka Suzuki
Department of Surgery, Jikei University School of Medicine, Tokyo, Japan
Bone 35:1346-52. 2004....
Association of extracellular matrix metalloproteinase inducer in endometrial carcinoma with patient outcomes and clinicopathogenesis using monoclonal antibody 12C3Kazu Ueda
Department of Obstetrics and Gynecology, Jikei University School of Medicine, Minato ku, Tokyo 105 8461, Japan
Oncol Rep 17:731-5. 2007..08; 95% CI, 1.32-7.19; P=0.01). These results suggest that measurement of EMMPRIN expression with simple immunohistochemical staining may enhance the understanding of the pathophysiology of endometrial carcinoma...
Impaired cardiovascular autonomic function in Parkinson's disease with visual hallucinationsHisayoshi Oka
Department of Neurology, Jikei University School of Medicine, Tokyo, Japan
Mov Disord 22:1510-4. 2007..Severe dysfunction in PD with VH is probably attributed to Lewy-body lesions or neuronal loss in sympathetic ganglia, the central autonomic system, or both...
Facilitated beam-walking recovery during acute phase by kynurenic acid treatment in a rat model of photochemically induced thrombosis causing focal cerebral ischemiaMasahiro Abo
Department of Rehabilitation, The Jikei University School of Medicine, Tokyo, Japan
Neurosignals 15:102-10. 2006..0001), as evaluated with beam walking. These results suggest that intrathecal administration of a glycine receptor antagonist may facilitate behavioral recovery during the acute phase after brain infarction...
Covering the percutaneous endoscopic gastrostomy (PEG) tube prevents peristomal infectionYutaka Suzuki
Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, and Department of Surgery, Mashiko Hospital, Saitama, Japan
World J Surg 30:1450-8. 2006....
Epidural administration of morphine facilitates time of appearance of first gastric interdigestive migrating complex in dogs with paralytic ileus after open abdominal surgeryTomoko Nakayoshi
Department of Surgery, Jikei University School of Medicine, Tokyo, Japan
J Gastrointest Surg 11:648-54. 2007..These results suggest that epidural administration of morphine may facilitate recovery from paralytic ileus after open abdominal surgery, perhaps through its effects on the central nervous system...
Serum vitamin D levels and survival of patients with colorectal cancer: post-hoc analysis of a prospective cohort studyHidetoshi Mezawa
Division of Molecular Epidemiology, Jikei University School of Medicine, Nishi Shimbashi, Minato ku, Tokyo, Japan
BMC Cancer 10:347. 2010..In this study, we directly measured serum 25OHD levels at surgery and examined the association with survival among patients with colorectal cancer...
Prognostic significance of vascular endothelial growth factor D in gastric carcinomaAtsuo Shida
Department of Surgery, Jikei University School of Medicine, Nishi-shinbashi, 3-25-8, Minato-ku, Tokyo, 105-8461, Japan
World J Surg 29:1600-7. 2005..Our data indicate the involvement of VEGF-D in tumor progression via lymphoangiogenic pathways. Practically, VEGF-D expression can be useful for predicting RFS and OS in patients with gastric carcinoma...
Placement of a metallic stent across the main duodenal papilla may predispose to cholangitisTomoyoshi Okamoto
Department of Surgery, School of Medicine, The Jikei University, Tokyo, Japan
Gastrointest Endosc 63:792-6. 2006..94-1.00). CONCLUSIONS: Disruption of the sphincter mechanism by transpapillary placement may be the most important etiologic factor in the propensity for cholangitis after metallic stent placement for malignant biliary obstruction...
Gene and protein expression profiling during differentiation of neuroblastoma cells triggered by 13-cis retinoic acidYuki Yuza
Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan
J Pediatr Hematol Oncol 25:715-20. 2003..CONCLUSIONS: These results suggest that microarray technology can screen for genes that are important in neuroblastoma differentiation...
Bimodal effects of obesity ratio on disease duration of respiratory syncytial virus infection in childrenNaoe Akiyama
Department of Pediatrics, Fuji Chuo Hospital, Shizuoka, Japan
Allergol Int 60:305-8. 2011..Thus, we examined association between obesity ratios and duration of disease in children with Respiratory Syncytial Virus (RSV) infection...
Risk of metabolic syndrome persists twenty years after the cessation of smokingTakashi Wada
Health Care Center, Shimbashi Medical Check up Office, Tokyo
Intern Med 46:1079-82. 2007..Smoking also causes insulin resistance to develop. To clarify whether smoking is correlated with MetS and how long MetS remains after smoking cessation we undertook a retrospective study...
Quantitative analysis of free ubiquitin and multi-ubiquitin chain in colorectal cancerYoshio Ishibashi
Department of Surgery, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
Cancer Lett 211:111-7. 2004..We conclude that the levels of FUb and MUC were up-regulated in colorectal cancer and were correlated with the pathological findings...
Cinacalcet for hemodialyzed patients with or without a high PTH level to control serum calcium and phosphorus: ECO (evaluation of cinacalcet HCl outcome) studyKeitaro Yokoyama
Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
Clin Nephrol 78:87-92. 2012..We investigated the influence of cinacalcet on serum Ca and P in hemodialyzed patients with or without a high PTH level, according to K/DOQI guideline, to control serum Ca and P levels...
Effective and safe conditions of low-frequency transcranial ultrasonic thrombolysis for acute ischemic stroke: neurologic and histologic evaluation in a rat middle cerebral artery stroke modelTakayuki Saguchi
Department of Neurosurgery, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
Stroke 39:1007-11. 2008..We examined the efficacy and safety of low-frequency TUS under appropriate conditions of ultrasound for thrombolytic treatment in a rat middle cerebral artery stroke model...
Color Doppler endoscopic ultrasonography in identifying groups at a high-risk of recurrence of esophageal varices after endoscopic treatmentAkira Kuramochi
Department of Endoscopy, The Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo, 105 8461, Japan
J Gastroenterol 42:219-24. 2007..However, the sample size was too small, and in this study we aimed to validate the results of the preliminary study...
Problematic behaviours of 3-year-old children in Japan: relationship with socioeconomic and family backgroundsSatoshi Teramoto
Department of Pediatrics, Jikei University School of Medicine, 163 1, Kashiwashita, Chiba 277 8567, Japan
Early Hum Dev 81:563-9. 2005..The purpose of our study was to elucidate factors in socioeconomic and family backgrounds of 3-year-old children in Tokyo, Japan that were associated with problematic behaviours among the children...
Diagnostic utility of narrow-band imaging endoscopy for pharyngeal superficial carcinomaNoboru Yoshimura
Department of Endoscopy, The Jikei University School of Medicine, Tokyo 105 8461, Japan
World J Gastroenterol 17:4999-5006. 2011..To investigate the endoscopic features of pharyngeal superficial carcinoma and evaluate the utility of narrow-band imaging (NBI) for this disease...
Influence of climate factors on emergency visits for childhood asthma attackMitsuo Hashimoto
Division of Clinical Research and Development, The Jikei University School of Medicine, Tokyo, Japan
Pediatr Int 46:48-52. 2004..CONCLUSIONS: These results suggest that these models might quantify contributions of specific climate conditions and other seasonal factors on the number of emergency visits per night for childhood asthma attack in Tokyo, Japan...
A cross-sectional study of the association between circulating 25-hydroxyvitamin D levels and predicted operative mortality of patients with cardiovascular diseaseYusuke Tsutsumi
Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan
J Nutr Sci Vitaminol (Tokyo) 58:327-32. 2012..These results suggest that serum 25OHD levels are inversely associated with operative risk severity of patients undergoing major cardiovascular surgery...
Usefulness of magnifying endoscopy with narrow band imaging for the detection of specialized intestinal metaplasia in columnar-lined esophagus and Barrett's adenocarcinomaKen ichi Goda
Department of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan
Gastrointest Endosc 65:36-46. 2007..Barrett's esophagus with specialized intestinal metaplasia (SIM) from columnar-lined esophagus is difficult to distinguish with routine endoscopy...
The maximum tumour length in biopsy cores as a predictor of outcome after radical prostatectomyNorihiro Hayashi
Department of Urology, Jikei University School of Medicine, Minato ku, Tokyo, Japan
BJU Int 101:175-80. 2008..To evaluate maximum tumour length (MTL) in biopsy cores as a predictor of prostate-specific antigen (PSA)-failure, systemic failure, and death from prostate cancer after radical prostatectomy (RP)...
Influence of hilar deposition in the evaluation of the alveolar epithelial permeability on 99mTc-DTPA aerosol inhaled scintigraphyShigeyuki Ogi
Department of Radiology, The Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, 105 8461, Japan
Jpn J Radiol 27:20-4. 2009..We investigated whether hilar radioaerosol deposition affects the clearance rate of technetium-99m-labeled diethylenetriaminepentaacetic acid ((99m)Tc-DTPA) from peripheral alveolar regions...
Effect of early statin treatment at standard doses on long-term clinical outcomes in patients with acute myocardial infarction (the Heart Institute of Japan, Department of Cardiology Statin Evaluation Program)Michitaka Nagashima
Department of Cardiology, The Heart Institute of Japan, Tokyo Women s Medical University, Tokyo, Japan
Am J Cardiol 99:1523-8. 2007..In conclusion, these findings suggest that initiating standard rather than intensive statin therapy immediately after AMI decreases long-term mortality and subsequent cardiac events...
A multi-center study on low-frequency rTMS combined with intensive occupational therapy for upper limb hemiparesis in post-stroke patientsWataru Kakuda
Department of Rehabilitation Medicine, The Jikei University School of Medicine, Nishi Shimbashi, Minato ku, Tokyo, Japan
J Neuroeng Rehabil 9:4. 2012..The aims of this pilot study were to confirm the safety and feasibility of the protocol in a large number of patients from different institutions, and identify predictors of the clinical response to the treatment...
Alendronate improves vitamin D-resistant osteopenia triggered by gastrectomy in patients with gastric cancer followed long termYutaka Suzuki
Department of Surgery, and Division of Clinical Research and Development, Jikei University School of Medicine, Tokyo, Japan
J Gastrointest Surg 9:955-60. 2005..01), and increased serum levels of intact parathyroid hormone (P<0.05), although body weight did not alter. These results suggest that bisphosphonate may improve osteopenia after gastrectomy/gastric bypass...
CD147 and matrix metalloproteinase-2 protein expression as significant prognostic factors in esophageal squamous cell carcinomaYoshio Ishibashi
Department of Surgery, Jikei University School of Medicine, Tokyo, Japan
Cancer 101:1994-2000. 2004....
Impaired myocardial 123I-metaiodobenzylguanidine uptake in Lewy body disease: comparison between dementia with Lewy bodies and Parkinson's diseaseMasahiko Suzuki
Department of Neurology, The Jikei University School of Medicine, 3 25 8, Nishi Shinbashi, Minato ku, Tokyo 105 8461, Japan
J Neurol Sci 240:15-9. 2006..Patients with LBD had marked reductions in cardiac MIBG accumulation, indicative of severe impairment of the cardiac sympathetic nervous systems. However, the differences in scintigraphy between DLB and PD have not been determined...
Association of polymorphism of estrogen receptor-alpha gene with circulating levels of adiponectin in postmenopausal women with type 2 diabetesRie Yoshihara
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
J Atheroscler Thromb 16:250-5. 2009..454-397T>C) might influence circulating levels of adipokines and inflammatory cytokines in postmenopausal women with type 2 diabetes...
Factors influencing subjective sleepiness in patients with obstructive sleep apnea syndromeKenichi Hayashida
Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
Psychiatry Clin Neurosci 61:558-63. 2007..These results suggest that subjective daytime sleepiness in patients with OSAS may be influenced not only by the severity of respiratory disorder indices but also by certain personality characteristics affecting Hs score and by age...
New evidence on pitavastatin: efficacy and safety in clinical studiesTamio Teramoto
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
Expert Opin Pharmacother 11:817-28. 2010..Many clinical trials of pitavastatin have been done since its launch. New insights on pitavastatin from these trials are summarized and evaluated...
Preoperative luteinizing hormone levels predict the ovulatory response to laparoscopic ovarian drilling in patients with clomiphene citrate-resistant polycystic ovary syndromeHiroshi Hayashi
Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan
Gynecol Endocrinol 21:307-11. 2005..Therefore, eligibility criteria for LOD should be strictly applied, since LOD for patients with inadequate LH levels is not only ineffective, but also may impair ovarian reserve...
[Serum S-100B protein and neuron-specific enolase after traumatic brain injury]Satoshi Sawauchi
Department of Neurosurgery, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
No Shinkei Geka 33:1073-80. 2005..The aim of this study was to investigate S-100B protein and NSE as a serum marker of brain cell damage after traumatic brain injury...
Simultaneous vaccination in Japanese travelersYasutaka Mizuno
Travel Clinic, Disease Control and Prevention Center, International Medical Center of Japan, Tokyo 162 8655, Japan
Travel Med Infect Dis 5:85-9. 2007..The objective of this study was to evaluate whether the frequency and severity of adverse effects are increased by simultaneous vaccination in comparison to single vaccination...
[Suppressive effect of angiotensin converting enzyme inhibitor (ACEI) on the progression of renal insufficiency: a propensity score analysis]Ayumi Hirabayashi
Department of Medicine IV, Tokyo Women's Medical University, Japan
Nippon Jinzo Gakkai Shi 46:35-42. 2004....
Profiling gene expression ratios of paired cancerous and normal tissue predicts relapse of esophageal squamous cell carcinomaYoshio Ishibashi
Department of Surgery, The Jikei University School of Medicine, Minato-ku, Tokyo 105-8461, Japan
Cancer Res 63:5159-64. 2003....
